Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of postsynaptic actin cytoskeleton

POTEF POTEE POTEI POTEJ

2.79e-07111104GO:0098973
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-7 ERVK-10 ERVK-8 ERVK-11

2.79e-07111104GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-7 ERVK-10 ERVK-8 ERVK-11

8.36e-07141104GO:0003964
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-7 ERVK-10 ERVK-8 ERVK-19 ERVK-25

1.75e-06371105GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-7 ERVK-10 ERVK-8 ERVK-19 ERVK-25

2.01e-06381105GO:0070001
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-7 ERVK-10 ERVK-8 ERVK-11

4.85e-06211104GO:0035613
GeneOntologyMolecularFunctionzinc ion binding

CALR TRIM26 CUL9 ZNF407 ERVK-7 ERVK-10 NR3C1 ZCCHC2 LCN1 APOBEC3A TRIM33 ERVK-8 ERVK-19 ZNF84 HERC2 TRIM36 ERVK-11

7.36e-0689111017GO:0008270
GeneOntologyMolecularFunctionstructural constituent of postsynapse

POTEF POTEE POTEI POTEJ

2.78e-05321104GO:0099186
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-7 ERVK-10 ERVK-8 ERVK-11

5.00e-05371104GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-7 ERVK-10 ERVK-8 ERVK-11

5.57e-05381104GO:0034061
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

VPS18 HECTD3 TRIM26 MAEA CUL9 HUWE1 TRIM33 CCAR1 HERC2 TRIM36 CDC23

6.07e-0547311011GO:0004842
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-7 ERVK-10 ZC3H12D ERVK-8 ERVK-11

7.54e-05791105GO:0004521
GeneOntologyMolecularFunctionstructural constituent of synapse

POTEF POTEE POTEI POTEJ

8.30e-05421104GO:0098918
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-7 ERVK-10 ERVK-8 ERVK-11

1.19e-04461104GO:0016893
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

VPS18 HECTD3 TRIM26 MAEA CUL9 HUWE1 TRIM33 CCAR1 HERC2 TRIM36 CDC23

1.23e-0451211011GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

VPS18 HECTD3 TRIM26 MAEA CUL9 HUWE1 TRIM33 CCAR1 HERC2 TRIM36 CDC23

1.71e-0453211011GO:0016755
GeneOntologyMolecularFunctiontransition metal ion binding

CALR TRIM26 CUL9 ZNF407 ERVK-7 ERVK-10 NR3C1 ZCCHC2 LCN1 APOBEC3A TRIM33 ERVK-8 ERVK-19 ZNF84 HERC2 TRIM36 ERVK-11

2.66e-04118911017GO:0046914
GeneOntologyMolecularFunctionacyltransferase activity

VPS18 NAA15 HECTD3 TRIM26 MAEA CUL9 HUWE1 DMAP1 TRIM33 CCAR1 HERC2 TRIM36 CDC23

3.39e-0477511013GO:0016746
GeneOntologyMolecularFunctionstructural molecule activity

EPPK1 CLTCL1 POTEF INSR ERVK-7 ERVK-10 NEB POTEE KRT222 ERVK-8 ERVK-19 ERVK-25 POTEI POTEJ

3.84e-0489111014GO:0005198
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

DOCK2 DOCK3 SH3BP1 RGS11 ANKRD27 KRIT1 ARHGEF9 ARHGEF4 HERC2 ARHGAP21

4.94e-0450711010GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

DOCK2 DOCK3 SH3BP1 RGS11 ANKRD27 KRIT1 ARHGEF9 ARHGEF4 HERC2 ARHGAP21

4.94e-0450711010GO:0030695
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

CHD9 ERVK-7 MSH4 ERVK-10 DDX11 ERVK-8 ERVK-11

6.24e-042621107GO:0140097
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-7 ERVK-10 ZC3H12D ERVK-8 ERVK-11

9.40e-041361105GO:0004540
GeneOntologyMolecularFunctionendonuclease activity

ERVK-7 ERVK-10 ZC3H12D ERVK-8 ERVK-11

9.40e-041361105GO:0004519
GeneOntologyMolecularFunctionubiquitin protein ligase activity

VPS18 TRIM26 MAEA CUL9 HUWE1 TRIM33 CCAR1 HERC2

1.06e-033721108GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

VPS18 TRIM26 MAEA CUL9 HUWE1 TRIM33 CCAR1 HERC2

1.62e-033981108GO:0061659
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

DOCK2 DOCK3 ANKRD27 ARHGEF9 ARHGEF4 HERC2

1.77e-032311106GO:0005085
GeneOntologyMolecularFunctionprotein phosphatase regulator activity

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

2.28e-031001104GO:0019888
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

MARS1 CHD9 ERVK-7 MSH4 ERVK-10 DDX11 ZC3H12D PCIF1 ERVK-8 ERVK-11

2.98e-0364511010GO:0140640
GeneOntologyMolecularFunctionphosphatase regulator activity

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

3.54e-031131104GO:0019208
GeneOntologyBiologicalProcessDNA integration

ERVK-7 ERVK-10 ERVK-8 ERVK-11

5.28e-07131104GO:0015074
GeneOntologyBiologicalProcesspostsynaptic actin cytoskeleton organization

POTEF POTEE POTEI POTEJ

2.16e-05311104GO:0098974
GeneOntologyBiologicalProcesspostsynaptic cytoskeleton organization

POTEF POTEE POTEI POTEJ

3.53e-05351104GO:0099188
GeneOntologyCellularComponentNuA4 histone acetyltransferase complex

POTEF DMAP1 POTEE POTEI POTEJ

6.62e-07321105GO:0035267
GeneOntologyCellularComponentH4/H2A histone acetyltransferase complex

POTEF DMAP1 POTEE POTEI POTEJ

6.62e-07321105GO:0043189
GeneOntologyCellularComponentprotein phosphatase type 2A complex

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

2.10e-06181104GO:0000159
GeneOntologyCellularComponentH4 histone acetyltransferase complex

POTEF DMAP1 POTEE POTEI POTEJ

3.80e-06451105GO:1902562
GeneOntologyCellularComponentprotein acetyltransferase complex

NAA15 POTEF DMAP1 POTEE POTEI POTEJ

1.85e-051041106GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

NAA15 POTEF DMAP1 POTEE POTEI POTEJ

2.41e-051091106GO:1902493
GeneOntologyCellularComponentactin cytoskeleton

FLT1 VPS18 MYO7A POTEF MAEA NEB POTEE DIAPH2 MYH15 POTEI POTEJ ARHGAP21

5.16e-0557611012GO:0015629
GeneOntologyCellularComponentactin filament

VPS18 POTEF POTEE DIAPH2 POTEI POTEJ

1.24e-041461106GO:0005884
GeneOntologyCellularComponenthistone acetyltransferase complex

POTEF DMAP1 POTEE POTEI POTEJ

1.39e-04941105GO:0000123
GeneOntologyCellularComponentphosphatase complex

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

2.01e-04551104GO:1903293
GeneOntologyCellularComponentprotein serine/threonine phosphatase complex

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

2.01e-04551104GO:0008287
GeneOntologyCellularComponentintracellular protein-containing complex

NAA15 MARS1 POTEF MAEA CUL9 AIP DMAP1 POTEE POTEI POTEJ FEM1A USP47 CDC23

1.79e-0397211013GO:0140535
DomainPP2A_PR55_CS

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

8.72e-1041034IPR018067
DomainPP2A_PR55

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

8.72e-1041034IPR000009
DomainPR55_2

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

8.72e-1041034PS01025
DomainPR55_1

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

8.72e-1041034PS01024
DomainActin_CS

POTEF POTEE POTEI POTEJ

1.51e-06161034IPR004001
DomainACTINS_2

POTEF POTEE POTEI POTEJ

1.96e-06171034PS00432
DomainActin/actin-like_CS

POTEF POTEE POTEI POTEJ

2.52e-06181034IPR020902
DomainACTINS_ACT_LIKE

POTEF POTEE POTEI POTEJ

3.17e-06191034PS01132
DomainFERM_M

MYO7A FRMD8 FRMD4B KRIT1 FRMD4A

5.30e-06461035PF00373
DomainAPC_su10/DOC_dom

HECTD3 CUL9 HERC2

5.61e-0671033IPR004939
DomainDOC

HECTD3 CUL9 HERC2

5.61e-0671033PS51284
DomainANAPC10

HECTD3 CUL9 HERC2

5.61e-0671033PF03256
DomainAPC10

HECTD3 CUL9 HERC2

5.61e-0671033SM01337
Domain-

MYO7A FRMD8 FRMD4B KRIT1 FRMD4A

7.27e-064910351.20.80.10
DomainFERM_central

MYO7A FRMD8 FRMD4B KRIT1 FRMD4A

7.27e-06491035IPR019748
DomainFERM_domain

MYO7A FRMD8 FRMD4B KRIT1 FRMD4A

7.27e-06491035IPR000299
DomainFERM/acyl-CoA-bd_prot_3-hlx

MYO7A FRMD8 FRMD4B KRIT1 FRMD4A

8.05e-06501035IPR014352
DomainFERM_1

MYO7A FRMD8 FRMD4B KRIT1 FRMD4A

8.05e-06501035PS00660
DomainFERM_2

MYO7A FRMD8 FRMD4B KRIT1 FRMD4A

8.05e-06501035PS00661
DomainFERM_3

MYO7A FRMD8 FRMD4B KRIT1 FRMD4A

8.05e-06501035PS50057
DomainBand_41_domain

MYO7A FRMD8 FRMD4B KRIT1 FRMD4A

8.05e-06501035IPR019749
DomainB41

MYO7A FRMD8 FRMD4B KRIT1 FRMD4A

8.05e-06501035SM00295
DomainAnkyrin_rpt

RAPH1 POTEF ANKRD27 KRIT1 POTEE CLPB POTEI POTEJ FEM1A

1.46e-052621039IPR002110
DomainActin

POTEF POTEE POTEI POTEJ

2.45e-05311034IPR004000
DomainActin

POTEF POTEE POTEI POTEJ

2.45e-05311034PF00022
DomainACTIN

POTEF POTEE POTEI POTEJ

2.45e-05311034SM00268
DomainTPR_REGION

NAA15 BBS4 AIP TTC21B CEP70 FEM1A CDC23

3.60e-051651037PS50293
DomainTPR

NAA15 BBS4 AIP TTC21B CEP70 FEM1A CDC23

3.60e-051651037PS50005
DomainAnk

POTEF ANKRD27 KRIT1 POTEE CLPB POTEI POTEJ FEM1A

3.83e-052281038PF00023
Domain-

POTEF ANKRD27 KRIT1 POTEE CLPB POTEI POTEJ FEM1A

6.93e-0524810381.25.40.20
DomainANK

POTEF ANKRD27 KRIT1 POTEE CLPB POTEI POTEJ FEM1A

7.54e-052511038SM00248
DomainANK_REPEAT

POTEF ANKRD27 KRIT1 POTEE CLPB POTEI POTEJ FEM1A

7.96e-052531038PS50088
DomainAnkyrin_rpt-contain_dom

POTEF ANKRD27 KRIT1 POTEE CLPB POTEI POTEJ FEM1A

8.19e-052541038IPR020683
DomainANK_REP_REGION

POTEF ANKRD27 KRIT1 POTEE CLPB POTEI POTEJ FEM1A

8.19e-052541038PS50297
DomainCul7

CUL9 HERC2

9.00e-0531032PF11515
DomainCPH_domain

CUL9 HERC2

9.00e-0531032IPR021097
DomainTPR_repeat

NAA15 BBS4 AIP TTC21B CEP70 CDC23

9.46e-051331036IPR019734
Domain-

NAA15 CLTCL1 BBS4 AIP TTC21B FEM1A CDC23

1.50e-0420710371.25.40.10
DomainDUF3338

FRMD4B FRMD4A

1.79e-0441032PF11819
DomainDUF3338

FRMD4B FRMD4A

1.79e-0441032IPR021774
DomainTPR-contain_dom

NAA15 BBS4 AIP TTC21B CEP70 CDC23

1.83e-041501036IPR013026
DomainAnk_2

POTEF ANKRD27 POTEE CLPB POTEI POTEJ FEM1A

1.89e-042151037PF12796
DomainTPR_8

NAA15 BBS4 TTC21B CDC23

2.08e-04531034PF13181
DomainDOCK_N

DOCK2 DOCK3

2.98e-0451032PF16172
DomainDOCK_N

DOCK2 DOCK3

2.98e-0451032IPR032376
DomainTPR-like_helical_dom

NAA15 CLTCL1 BBS4 AIP TTC21B FEM1A CDC23

3.08e-042331037IPR011990
DomainHECT

HECTD3 HUWE1 HERC2

4.33e-04271033PF00632
DomainHECTc

HECTD3 HUWE1 HERC2

4.33e-04271033SM00119
DomainHECT_dom

HECTD3 HUWE1 HERC2

4.33e-04271033IPR000569
DomainHECT

HECTD3 HUWE1 HERC2

4.33e-04271033PS50237
DomainARM-type_fold

DOCK2 DOCK3 CLTCL1 CUL9 HUWE1 FOCAD DIAPH2 USP35

5.78e-043391038IPR016024
DomainClathrin

VPS18 CLTCL1

6.21e-0471032PF00637
DomainTPR_11

BBS4 CDC23

6.21e-0471032PF13414
DomainCHCR

VPS18 CLTCL1

6.21e-0471032PS50236
Domain-

HECTD3 DCBLD1 CUL9 HERC2

7.09e-047310342.60.120.260
DomainFERM_N

MYO7A FRMD4B FRMD4A

7.88e-04331033IPR018979
DomainFERM_N

MYO7A FRMD4B FRMD4A

7.88e-04331033PF09379
DomainClathrin_H-chain/VPS_repeat

VPS18 CLTCL1

8.25e-0481032IPR000547
DomainSH3

DOCK2 DOCK3 MYO7A NEB ARHGEF9 ARHGEF4

1.26e-032161036SM00326
DomainSH3

DOCK2 DOCK3 MYO7A NEB ARHGEF9 ARHGEF4

1.26e-032161036PS50002
DomainSH3_domain

DOCK2 DOCK3 MYO7A NEB ARHGEF9 ARHGEF4

1.38e-032201036IPR001452
DomainDHR-1_domain

DOCK2 DOCK3

1.60e-03111032IPR027007
DomainDHR_2

DOCK2 DOCK3

1.60e-03111032PS51651
DomainDHR_1

DOCK2 DOCK3

1.60e-03111032PS51650
DomainDHR-2

DOCK2 DOCK3

1.60e-03111032PF06920
DomainDOCK

DOCK2 DOCK3

1.60e-03111032IPR026791
DomainDOCK_C

DOCK2 DOCK3

1.60e-03111032IPR010703
DomainDOCK-C2

DOCK2 DOCK3

1.60e-03111032PF14429
DomainDHR-2

DOCK2 DOCK3

1.60e-03111032IPR027357
DomainGalactose-bd-like

HECTD3 DCBLD1 CUL9 HERC2

1.82e-03941034IPR008979
DomainER_TARGET

EOGT CALR UGGT1

2.21e-03471033PS00014
DomainTPR_2

NAA15 BBS4 AIP

2.65e-03501033PF07719
DomainTPR_2

NAA15 BBS4 AIP

2.65e-03501033IPR013105
DomainUbiquitin-rel_dom

RAPH1 MYO7A FRMD4B FRMD4A USP47

3.53e-031841035IPR029071
DomainRib_L2_dom2

CUL9 HERC2

4.35e-03181032IPR014722
Domain-

CUL9 HERC2

4.35e-031810322.30.30.30
PathwayKEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

2.29e-0619724M47525
PathwayKEGG_MEDICUS_REFERENCE_CD80_CD86_CTLA4_PP2A_SIGNALING_PATHWAY

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

4.27e-0622724M47919
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

DOCK3 HLCS CUL9 CHD9 AIP HUWE1 FRMD4B KRIT1 DMAP1 MAPK8IP3 FOCAD TRIM33 CLPB KRT222 CEP70 LRP1 CCAR1 ZNF84 HERC2 ARHGAP21 USP47

9.73e-1012851132135914814
Pubmed

HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

3.67e-097113425816751
Pubmed

The role of Vpr in HIV-1 pathogenesis.

NR3C1 PPP2R2A PPP2R2B PPP2R2C

7.32e-098113415638722
Pubmed

Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

1.31e-089113419762425
Pubmed

Evolution and expression of chimeric POTE-actin genes in the human genome.

POTEF POTEE POTEJ

3.34e-083113317101985
Pubmed

Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits.

PPP2R2A PPP2R2B PPP2R2C

3.34e-08311339514514
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

TRIM26 CUL9 AIP HUWE1 NR3C1 ZCCHC2 DDX11 POTEE TRIM33 UNK POTEI POTEJ CDC23

6.63e-085881131338580884
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DOCK3 EPPK1 CLTCL1 MYO7A MAEA CUL9 FRMD8 HUWE1 SAP30 MAPK8IP3 FOCAD DIAPH2 C19orf44 ARHGEF4 HERC2 FEM1A ARHGAP21

1.09e-0711051131735748872
Pubmed

Identification of a novel actin isoform in hepatocellular carcinoma.

POTEF POTEE POTEI POTEJ

1.40e-0715113416824795
Pubmed

Activation of protein phosphatase-2A1 by HIV-1 Vpr cell death causing peptide in intact CD(4+) T cells and in vitro.

PPP2R2A PPP2R2B PPP2R2C

3.32e-075113315578586
Pubmed

Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

3.94e-0719113432582689
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

HECTD3 CUL9 AIP KIF7 CCAR1 HERC2 USP47 CDC23

4.94e-07212113833853758
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-7 ERVK-10 ERVK-8 ERVK-19 ERVK-25 ERVK-11

6.64e-0794113621542922
Pubmed

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.

POTEF LCN1 FRMD4B POTEE POTEI POTEJ

7.52e-0796113623580065
Pubmed

Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.

DOCK2 DOCK3 MYO7A ARHGEF9 ARHGEF4

1.11e-0656113522745667
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

EOGT MARS1 TRIM26 MAEA INSR CHD9 ATP8B1 HUWE1 MAPK8IP3 PPP2R2A PPP2R2C ARHGEF9 TTC21B LRP1 CCAR1 ZNF84 ARHGEF4 NPAS2

1.49e-0614891131828611215
Pubmed

Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.

POTEE POTEI POTEJ

2.77e-069113316364570
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

FLT1 CUL9 ATP8B1 ZCCHC2 FRMD4A SCN9A HERC2 FEM1A ARHGAP21

3.66e-06371113915747579
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

CLTCL1 RAPH1 POTEF SPEF2 UGGT1 RGS11 NEB DDX11 POTEE SCN9A CCAR1 MYH15 ZNF84 ARHGEF4 POTEI POTEJ ARHGAP21

4.21e-0614421131735575683
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

FLT1 MYO7A MARS1 CHD9 NEB SCN9A DIAPH2 CCAR1 ARHGAP21 CDC23

5.42e-064971131036774506
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

DOCK2 DOCK3 EPPK1 RAPH1 CALR UGGT1 SH3BP1 HUWE1 POTEE ARHGEF9 CCAR1 ARHGEF4 ARHGAP21

9.15e-069161131332203420
Pubmed

Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.

PPP2R2A PPP2R2B PPP2R2C

9.33e-0613113318971272
Pubmed

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.

POTEF LCN1 KRIT1 POTEE POTEI POTEJ

9.68e-06149113622664934
Pubmed

Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice.

INSR NR3C1

1.05e-052113219759515
Pubmed

Expression and regulation of CReMM, a chromodomain helicase-DNA-binding (CHD), in marrow stroma derived osteoprogenitors.

CHD9 NR3C1

1.05e-052113216523501
Pubmed

Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.

PPP2R2A PPP2R2B

1.05e-052113224244166
Pubmed

A primate-specific POTE-actin fusion protein plays a role in apoptosis.

POTEF POTEE

1.05e-052113219669888
Pubmed

Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells.

POTEE POTEJ

1.05e-052113218447647
Pubmed

The rheumatoid arthritis shared epitope triggers innate immune signaling via cell surface calreticulin.

CALR LRP1

1.05e-052113217947714
Pubmed

Calreticulin and Hsp90 stabilize the human insulin receptor and promote its mobility in the endoplasmic reticulum.

CALR INSR

1.05e-052113217563366
Pubmed

Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling.

PPP2R2D PPP2R2A

1.05e-052113218697906
Pubmed

Modulation of gene expression by calreticulin binding to the glucocorticoid receptor.

CALR NR3C1

1.05e-05211328107808
Pubmed

Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors.

CALR NR3C1

1.05e-05211329089287
Pubmed

Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.

PPP2R2A PPP2R2B PPP2R2C

1.18e-051411339013886
Pubmed

The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.

HUWE1 TRIM33 HERC2

1.18e-0514113327626314
Pubmed

Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production.

PPP2R2A PPP2R2B PPP2R2C

1.18e-051411339400615
Pubmed

Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.

PPP2R2A PPP2R2B PPP2R2C

1.18e-0514113316048649
Pubmed

Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration.

PPP2R2A PPP2R2B PPP2R2C

1.48e-0515113316041367
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

HECTD3 CUL9 HUWE1 TRIM33 HERC2

1.52e-0595113529643511
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

NAA15 PPP2R2D CALR TRIM26 UGGT1 MAEA AIP HUWE1 KIF7 PPP2R2A CLPB LRP1 USP47

1.75e-059741131328675297
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

RAPH1 SPEF2 ZNF407 ZCCHC2 UNK

2.15e-05102113511214970
Pubmed

Regulation of HIV-1 transcription by protein phosphatase 1.

PPP2R2A PPP2R2B PPP2R2C

2.20e-0517113317266553
Pubmed

[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].

PPP2R2A PPP2R2B PPP2R2C

2.20e-0517113321351466
Pubmed

An integrated workflow for charting the human interaction proteome: insights into the PP2A system.

PPP2R2D DMAP1 PPP2R2A PPP2R2B PPP2R2C

2.47e-05105113519156129
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

NAA15 PPP2R2D SH3BP1 KRIT1 PPP2R2A CLPB SCN9A UNK HERC2

2.61e-05475113931040226
Pubmed

Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes.

PPP2R2A PPP2R2B PPP2R2C

2.63e-0518113323287597
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-10 ERVK-25 ERVK-11

2.63e-0518113318664271
Pubmed

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.

EXOC6 PPP2R2D UGGT1 HUWE1 ANKRD27 KIF7 PPP2R2A PPP2R2B HERC2 ARHGAP21

2.98e-056061131036538041
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

NAA15 PPP2R2D CHD9 PPP2R2A HERC2 USP47

3.10e-05183113636129980
Pubmed

Calreticulin mediated glucocorticoid receptor export is involved in beta-catenin translocation and Wnt signalling inhibition in human osteoblastic cells.

CALR NR3C1

3.13e-053113219100874
Pubmed

The zinc-finger protein ZCCHC2 suppresses retinoblastoma tumorigenesis by inhibiting HectH9-mediated K63-linked polyubiquitination and activation of c-Myc.

HUWE1 ZCCHC2

3.13e-053113231677785
Pubmed

Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice.

PPP2R2A PPP2R2B

3.13e-053113216102737
Pubmed

Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly.

CALR LRP1

3.13e-053113212821648
Pubmed

Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform.

PPP2R2A PPP2R2B

3.13e-05311321849734
Pubmed

FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth.

FRMD8 FRMD8P1

3.13e-053113237527040
Pubmed

CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes.

NR3C1 CCAR1

3.13e-053113218722177
Pubmed

Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis.

CALR LRP1

3.13e-053113218653767
Pubmed

Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes.

INSR PPP2R2A

3.13e-053113226868295
Pubmed

Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.

INSR LRP1

3.13e-053113219815552
Pubmed

The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth.

FRMD8 FRMD8P1

3.13e-053113236720499
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

CALR TRIM26 MAEA CUL9 CHD9 TRIM33 CDC23

3.97e-05282113723667531
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

EXOC6 HECTD3 MYO7A NR3C1 NEB KIF7 PPP2R2B GPATCH11 POTEJ USP47

4.59e-056381131031182584
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

ZNF487 VPS18 MYO7A POTEF NEB POTEE TTC21B GPATCH11 HERC2

4.74e-05513113925798074
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-7 ERVK-10

6.25e-054113210469592
Pubmed

TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.

TRIM26 HUWE1

6.25e-054113237324936
Pubmed

In-depth genetic and molecular characterization of diaphanous related formin 2 (DIAPH2) and its role in the inner ear.

MYO7A DIAPH2

6.25e-054113236689403
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-10 ERVK-19

6.25e-05411327983737
Pubmed

The low-density lipoprotein receptor-related protein associates with calnexin, calreticulin, and protein disulfide isomerase in receptor-associated-protein-deficient fibroblasts.

CALR LRP1

6.25e-054113214980518
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

EPPK1 PPP2R2D HECTD3 CALR TRIM26 MAEA PPP2R2A HERC2 CDC23

6.35e-05533113925544563
Pubmed

HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.

PPP2R2A PPP2R2B PPP2R2C

8.22e-0526113311531413
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

PPP2R2D MAEA CHD9 TTC21B USP47 CDC23

9.27e-05223113633187986
Pubmed

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.

FRMD8 FRMD8P1

1.04e-045113229897336
Pubmed

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.

FRMD8 FRMD8P1

1.04e-045113229897333
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

NEB SCN9A

1.04e-04511328812438
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-7 ERVK-19

1.04e-045113212629516
Pubmed

Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.

NR3C1 KRIT1

1.04e-045113231776290
Pubmed

Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.

PPP2R2A PPP2R2B

1.04e-045113217529992
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

CLTCL1 PPP2R2D CALR HLCS DMAP1 PPP2R2A PPP2R2B PPP2R2C POTEI

1.10e-04573113928330616
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

EPPK1 CLTCL1 UGGT1 POTEE DIAPH2 CCAR1

1.23e-04235113630258100
Pubmed

Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway.

FRMD8 FRMD8P1

1.56e-046113229776906
Pubmed

Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis.

PPP2R2D PPP2R2A

1.56e-046113220220139
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

EXOC6 VPS18 KIF7 DDX11 TTC21B USP47

1.77e-04251113629778605
Pubmed

The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.

EPPK1 TRIM26 MAEA HUWE1 ZCCHC2 SAP30

1.84e-04253113629911972
Pubmed

Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.

PPP2R2D PPP2R2A PPP2R2B HERC2

1.91e-0487113417148452
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CHD9 HUWE1 MAPK8IP3 FRMD4A

1.91e-0487113412465718
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DOCK2 DOCK3 VPS18 ZNF618 ZNF407 ZCCHC2 SAMD9L TTC21B

2.15e-04493113815368895
Pubmed

Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15.

PPP2R2D PPP2R2B

2.17e-047113223135275
Pubmed

Congenital Insensitivity to Pain Overview

CLTCL1 SCN9A

2.17e-047113229419974
Pubmed

Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development.

PPP2R2A PPP2R2B PPP2R2C

2.21e-0436113322422068
Pubmed

Scanning the human proteome for calmodulin-binding proteins.

DOCK3 HUWE1 NEB HERC2

2.37e-0492113415840729
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

EPPK1 CLTCL1 UGGT1 CUL9 HUWE1 PPP2R2A CEP70 HERC2 CDC23

2.47e-04639113923443559
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

EPPK1 CLTCL1 PPP2R2D CALR MARS1 UGGT1 HUWE1 PPP2R2A PPP2R2B

2.71e-04647113926618866
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

HECTD3 ZNF618 HLCS CUL9 CHD9 SAP30 DMAP1 KIF7 TRIM33 PPP2R2A LRP1 CDC23

2.83e-0411161131231753913
Pubmed

Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A.

PPP2R2B PPP2R2C

2.89e-048113212912990
Pubmed

Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest.

PPP2R2A PPP2R2B

2.89e-048113211956189
Pubmed

Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.

PPP2R2A PPP2R2C

2.89e-048113211007961
Pubmed

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.

FRMD4B FRMD4A

2.89e-048113220080746
Pubmed

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

PPP2R2A PPP2R2B

2.89e-048113217245430
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

EPPK1 NAA15 CALR UGGT1 CUL9 HUWE1 CCAR1 HERC2 USP47

2.90e-04653113922586326
Pubmed

The tripartite motif family identifies cell compartments.

TRIM26 TRIM33 TRIM36

3.25e-0441113311331580
InteractionSERTAD4 interactions

PPP2R2D POTEF PPP2R2A PPP2R2B PPP2R2C

4.41e-08191085int:SERTAD4
InteractionPOTEJ interactions

INSR CUL9 NR3C1 POTEE POTEI POTEJ

3.43e-07521086int:POTEJ
InteractionIER5 interactions

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

5.37e-07131084int:IER5
InteractionACTG2 interactions

POTEF NEB POTEE POTEI POTEJ

6.36e-06491085int:ACTG2
InteractionPABIR1 interactions

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

2.20e-05311084int:PABIR1
InteractionIER2 interactions

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

4.50e-05371084int:IER2
InteractionSFTPA2 interactions

EOGT CLTCL1 POTEF NR3C1

5.00e-05381084int:SFTPA2
InteractionSERTAD2 interactions

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

5.55e-05391084int:SERTAD2
InteractionNEK4 interactions

ZNF487 VPS18 MYO7A POTEF NR3C1 NEB POTEE CLPB TTC21B GPATCH11 HERC2 TRIM36

6.72e-0558210812int:NEK4
Cytoband2q22

NEB ARHGEF4

5.90e-06211222q22
Cytoband2q21.1

POTEF POTEE POTEI POTEJ

1.29e-055811242q21.1
CytobandEnsembl 112 genes in cytogenetic band chr2q21

POTEF POTEE ARHGEF4 POTEI POTEJ

3.64e-051511125chr2q21
Cytoband19p13.3-p13.2

CALR INSR

5.27e-0414112219p13.3-p13.2
Cytoband7q21.2

KRIT1 SAMD9L

6.07e-041511227q21.2
Cytoband3p14.1

EOGT FRMD4B

1.57e-032411223p14.1
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEF POTEE POTEI POTEJ

2.00e-0713764685
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

3.80e-0715764696
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

MYO7A FRMD8 FRMD4B KRIT1 FRMD4A

2.10e-06507651293
GeneFamilyAnkyrin repeat domain containing

POTEF ANKRD27 KRIT1 POTEE CLPB POTEI POTEJ FEM1A

7.90e-06242768403
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)-D122|Adult / Lineage, Cell type, age group and donor

DOCK2 MYO7A FRMD4B FRMD4A ZC3H12D LRP1

3.06e-061661076be284e2e596390f05305c7bcfc316f87b963fc0b
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZNF487 DCBLD1 SAP30 APOBEC3A GBGT1 ARHGAP21

6.45e-061891076a2f4f1dd5452f7efb7427919a0b90875cf2e1dc7
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF487 DCBLD1 SAP30 APOBEC3A GBGT1 ARHGAP21

6.45e-06189107654a45b0cb7dea01caf1cf0a2664c40e5779a0b61
ToppCellproximal-Hematologic-Platelet/Megakaryocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZNF487 VPS18 CABP7 CLPB TRIM36 NPAS2

7.06e-061921076522d1bb15edf1d6006b80289bd3baadb99584ae8
ToppCellproximal-3-Hematologic-Platelet/Megakaryocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZNF487 VPS18 CABP7 CLPB TRIM36 NPAS2

7.06e-061921076f5f83dec37dff32a0c471cb05d23d13b0b0ad0c9
ToppCellproximal-Hematologic-Platelet/Megakaryocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZNF487 VPS18 CABP7 CLPB TRIM36 NPAS2

7.06e-06192107657899a905ca3e336bb7f31edc6418a2546b9891a
ToppCellTCGA-Brain-Primary_Tumor-Glioblastoma-Primary_GBM-11|TCGA-Brain / Sample_Type by Project: Shred V9

POTEF POTEE POTEI POTEJ

1.62e-05631074d7dc1356a60cb527fe668328d5375f352239d911
ToppCellfacs-Trachea-nan-18m-Myeloid-lymphocyte_of_B_lineage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK3 DMAP1 KRT222 ZC3H12D GPATCH11

4.24e-0516010755c9281706009558c8361bfa76169f43ffc0f7947
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

EOGT INSR FRMD8 ATP8B1 MTBP

5.98e-051721075c3a99828838af3b85c8c885d69cc8018f55ced50
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MYO7A CHD9 PPP2R2B KLRF1 KIR3DX1

5.98e-051721075e3a8891694343b6b01e80a200ae338d24797e417
ToppCellnormal_Lung-T/NK_cells-Exhausted_Tfh|normal_Lung / Location, Cell class and cell subclass

DOCK3 PPP2R2D MYO7A NR3C1 MTBP

6.14e-051731075e8ead6c51c41dbd43c717ba9d1a7a0ab39c79330
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLT1 ACER1 DCBLD1 USHBP1 KRT222

6.49e-0517510757be76d39e1a4f4ac709672cd2d409a2523a083ce
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-9|TCGA-Breast / Sample_Type by Project: Shred V9

POTEF POTEE POTEI POTEJ

6.60e-0590107496e836c7a1df279ac812b7c3aa75e6b81b614244
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.6.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DOCK2 SAP30 GBGT1 GPATCH11 LRP1

6.84e-051771075929cd8f530ce001623735da53b7278d02522e2b5
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-8|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FLT1 ZNF618 NEB ZNF84 ARHGEF4

6.84e-051771075066e7500e7bdde88a7914f50a4661d8adf6db925
ToppCellT_cells-TFH-like_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

FLT1 MYO7A NR3C1 FRMD4B ZC3H12D

7.03e-051781075e2ae43e5ec31de6197f2cbd6089f944adbf0a163
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 EOGT CYTL1 PPP2R2C USHBP1

7.22e-051791075a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK3 RGS11 PPP2R2C SCN9A TRIM36

8.65e-05186107518fd311252299d6d30ddb32002ed069056108206
ToppCellMonocytes-M2-like_CD16+_macrophages|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis

MYO7A CYTL1 NEB FRMD4B FRMD4A

8.87e-05187107559e31c51183ed4c9a3d0792c8005ea3a12b28dfa
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_3|COVID-19_Convalescent / Disease condition and Cell class

ZNF487 DCBLD1 GBGT1 UNK ARHGAP21

9.32e-051891075732e8dcffcb634ca2968f9170c9c4b31dd5d4206
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK2 MYO7A FRMD4B FRMD4A SCN9A

9.56e-051901075f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLT1 EOGT ATP8B1 CYTL1 USHBP1

1.00e-041921075285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

EXOC6 FLT1 SPEF2 HLCS ATP8B1

1.03e-0419310756e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellAdult-Immune-interstitial_macrophage_(C1Q_positive)|Adult / Lineage, Cell type, age group and donor

DOCK2 MYO7A FRMD4B FRMD4A LRP1

1.03e-04193107531c0978ba78c9516d498aec0798902e57555e557
ToppCellImmune-interstitial_macrophage_(C1Q_positive)|World / Lineage, Cell type, age group and donor

DOCK2 MYO7A FRMD4B FRMD4A SCN9A

1.03e-04193107564d598162a256ac6c9f8280c8a9133661dfbb10f
ToppCelldistal-1-Hematologic-IGSF21+_Dendritic|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZNF618 CYTL1 FRMD4B SAP30 ZC3H12D

1.05e-041941075f30c866e5f41ee79bdc6b6e08af962d62b199835
ToppCellfacs-Brain_Myeloid-Hippocampus|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CALR CHD9 NR3C1 LRP1 HERC2

1.08e-041951075a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK3 RGS11 PPP2R2B SCN9A TRIM36

1.08e-0419510755a6a5048af638872700b76b7c71a8fa3fb8d3772
ToppCellASK428-Endothelial-Endothelium|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

FLT1 INSR CYTL1 USHBP1 MYH15

1.11e-041961075b1a81eddb91fb462360692b7b0a3ba4a947eac40
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn-38|World / Primary Cells by Cluster

CHD9 FRMD4B FRMD4A PPP2R2B ARHGAP21

1.11e-04196107538da0751941adca650fe9b383d9f343153978eb5
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-IPC/newborn|World / Primary Cells by Cluster

CHD9 FRMD4B FRMD4A PPP2R2B ARHGAP21

1.11e-041961075721650a08d260faf530dbd52d4e9275d27f3bac2
ToppCellproximal-Hematologic-Interstitial_Macrophage|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DOCK2 DOCK3 MYO7A CYTL1 TRIM36

1.11e-041961075b6a858c43fef42cd724d56c8283e954bcb546106
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

CHD9 FRMD4A SAMD9L GPATCH11 LRP1

1.11e-0419610755ed7f063fc4ba213fe15256caf77f59c9e476290
ToppCellproximal-3-Hematologic-Interstitial_Macrophage|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DOCK2 DOCK3 MYO7A CYTL1 TRIM36

1.11e-041961075d8c9cb86233470c3044865ad05ea202e294d80bf
ToppCellproximal-Hematologic-Interstitial_Macrophage-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

DOCK2 DOCK3 MYO7A CYTL1 TRIM36

1.11e-0419610759d4d8ffe9d30de7d1dc33d261bc2aaf4189ad86c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FLT1 EOGT INSR USHBP1 NPAS2

1.16e-04198107572e8b9cccb7b0a2ea9d415218fff4fa2f09728f4
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

MYO7A MSH4 CYTL1 UNC13C LRRC17

1.16e-0419810750c4d2c68a42f8a9e964e2dd28092fe75f5216834
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 MYO7A FRMD4A SCN9A LRP1

1.16e-041981075c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCellLPS_only-Epithelial_airway-airway_epithelial-Ciliated|LPS_only / Treatment groups by lineage, cell group, cell type

TSNAXIP1 MYO7A INSR ZMYND10 MDH1B

1.16e-0419810756d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FLT1 EOGT INSR USHBP1 NPAS2

1.19e-0419910759c40b3ee39860e9d8edafd007daec11abdd95435
ToppCellTracheal-NucSeq-Immune_Lymphocytic-NK-ILC|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 GIMAP2 PPP2R2B KLRF1 KIR3DX1

1.19e-041991075713fab2e946b300d21215aff1553785e8857ce65
ToppCellCOVID-19-COVID-19_Severe-Others-HSPC|COVID-19_Severe / Disease, condition lineage and cell class

ZNF618 CYTL1 SCN9A CEP70 PRKG2

1.19e-04199107525de67b6c9c8d6bb9a538e071a40ef865906c95d
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FLT1 EOGT INSR USHBP1 NPAS2

1.19e-04199107572b34bce8157abe389e95cd3ed8ba578dce0cbf6
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Transverse / Region, Cell class and subclass

RAPH1 MYO7A CYTL1 SCN9A LRP1

1.19e-041991075facf79c256db5ae57bdb613e86ec90616a6f67ca
ToppCellTransverse-(6)_Macrophage-(61)_LYVE1_Macrophage|Transverse / shred on region, Cell_type, and subtype

RAPH1 MYO7A CYTL1 SCN9A LRP1

1.19e-041991075dcc2a7f4d1fa30aaaad655dd59c5a2b039d264bf
ToppCellTracheal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK2 GIMAP2 PPP2R2B KLRF1 KIR3DX1

1.19e-041991075ffd5b4d58d81b76e01d87016209f16879d81c592
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

EXOC6 FLT1 SPEF2 USHBP1 DIAPH2

1.22e-0420010753b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

EXOC6 FLT1 SPEF2 USHBP1 DIAPH2

1.22e-042001075a2b9d1cd291d17abddc3ee2e242121412c864b8b
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

PPP2R2D PPP2R2A PPP2R2B PPP2R2C

6.52e-08121024DOID:1441 (implicated_via_orthology)
Diseaseelectroencephalogram measurement

FRMD4B FOCAD PPP2R2C PRKG2

1.29e-04741024EFO_0004357
DiseaseSchizoaffective Disorder

CALR NR3C1 NPAS2

1.37e-04291023C0036337
DiseaseCongenital Pain Insensitivity

CLTCL1 SCN9A

2.46e-0471022C0002768
Diseaseprimary ovarian insufficiency (is_implicated_in)

MSH4 DIAPH2

3.27e-0481022DOID:5426 (is_implicated_in)
DiseaseCiliopathies

MYO7A BBS4 KIF7 TTC21B

5.87e-041101024C4277690
DiseasePathological accumulation of air in tissues

PPP2R2A PPP2R2C

7.64e-04121022C0013990
Diseasecongenital diaphragmatic hernia (implicated_via_orthology)

KIF7 LRP1

7.64e-04121022DOID:3827 (implicated_via_orthology)
Diseaseserum alanine aminotransferase measurement

FLT1 INSR FRMD8 ATP8B1 CYTL1 DDX11 UNK NDUFAF6 USP35 ARHGEF4

8.64e-0486910210EFO_0004735
Diseaseidiopathic scoliosis (implicated_via_orthology)

KIF7 ZMYND10

1.38e-03161022DOID:0060250 (implicated_via_orthology)
Diseasefilaggrin gene expression measurement

ZNF618 FRMD4A

1.38e-03161022EFO_0020899
DiseaseBardet-Biedl syndrome 1 (disorder)

BBS4 KIF7

1.56e-03171022C2936862
DiseaseAbdominal Aortic Aneurysm

USHBP1 PCIF1 LRP1

1.71e-03681023EFO_0004214
Diseaseresting heart rate

EPPK1 FRMD4B ARHGAP21 CDC23

1.81e-031491024EFO_0004351
Diseaseprimary ciliary dyskinesia (implicated_via_orthology)

SPEF2 ZMYND10

1.95e-03191022DOID:9562 (implicated_via_orthology)
DiseaseFamilial aplasia of the vermis

KIF7 TTC21B

2.16e-03201022cv:C0431399

Protein segments in the cluster

PeptideGeneStartEntry
LQYSEHCEEAYRVLL

USHBP1

346

Q8N6Y0
YLKAKRYVDSIDICH

TTC21B

1276

Q7Z4L5
YDVIHLKTYDSKRVC

EOGT

296

Q5NDL2
EECRKELTALLHHYY

NT5C3B

71

Q969T7
IETYQVHDYLRSKLC

PPP2R2B

316

Q00005
VHDYLRSKLCSLYEN

PPP2R2B

321

Q00005
IETYQVHDYLRSKLC

PPP2R2C

316

Q9Y2T4
VHDYLRSKLCSLYEN

PPP2R2C

321

Q9Y2T4
LHYIRKDYEACKAVI

BBS4

41

Q96RK4
LSYLAHNLCEIDKYR

CDC23

316

Q9UJX2
LHILYIVCQEYRKTS

ACER1

151

Q8TDN7
ETYQVHEYLRSKLCS

PPP2R2A

321

P63151
HEYLRSKLCSLYEND

PPP2R2A

326

P63151
HCGYLLEKDLEEILY

CCAR1

936

Q8IX12
IGRHKTYLCYEVERL

APOBEC3A

26

P31941
LEEPSRYIDISKCHY

ALG9

521

Q9H6U8
RYIDISKCHYLVDLD

ALG9

526

Q9H6U8
KVEQCRDEYLADLYH

SH3BP1

201

Q9Y3L3
ERDYIKHLRDICEGY

ARHGEF4

296

Q9NR80
VHEYLRSKLCSLYEN

PPP2R2D

331

Q66LE6
SHYIDIERKLFDETC

CALHM1

221

Q8IU99
LLHFIADICEEKYRD

DIAPH2

876

O60879
LYCKGADTVIYERLH

ATP8B1

616

O43520
KLVVEEYYEVLDHCS

AIP

241

O00170
RHYIKHLKDICEGYL

ARHGEF9

116

O43307
YIKYLCCDDVRTLHQ

RAPH1

481

Q70E73
GTLVDYEKDCYDRLH

RGS11

136

O94810
DYYHIDDLELLARCH

NPAS2

286

Q99743
KALVYYDVESCRLDI

ANKRD27

546

Q96NW4
EEYHRICELLSDYKE

POTEF

466

A5A3E0
EHLLRCGYYNTAVKL

MAEA

131

Q7L5Y9
IYREFERLIHCYDEE

MAPK8IP3

36

Q9UPT6
CTEYHRYIEIAIKQC

HERC2

2881

O95714
CEAALGTHYRAYLLK

FRMD8

246

Q9BZ67
HEKYLDCQERKLVYV

LRRC17

61

Q8N6Y2
IERCEYDGSHRYVIL

LRP1

2401

Q07954
CEAALGTHYRAYLLK

FRMD8P1

246

Q9BZ68
LADCVDIDSYILYHL

HLCS

186

P50747
HLLEKEEIRYYGCIQ

KRT222

141

Q8N1A0
TKLIYHTYCERVALV

OR52A4P

176

A6NMU1
GTDHYCLELLRKRDY

NDUFAF6

56

Q330K2
LLDCLVHVSYLEVYK

KIF7

136

Q2M1P5
YIIHYIDDILCAAET

HERVK_113

191

P63132
IIRSHVKDHYIFYCE

LCN1

106

P31025
REYRAKSYEILLHEV

KRIT1

26

O00522
SELHRLQVSYEEYLC

NR3C1

651

P04150
VSYRRYGDEELHLCV

INSR

886

P06213
LEEEHITKIYYCSRT

DDX11

221

Q96FC9
LYLDIHNYCVLDKLR

CYTL1

61

Q9NRR1
FIYRLEHEVDLCRKE

HUWE1

456

Q7Z6Z7
YIIHYIDDILCAAET

ERVK-7

191

P63135
VYRCLHIYSVLGDEE

EXOC6

286

Q8TAG9
EHVYSEKRILEELCS

PRKG2

496

Q13237
RCHSELAFDEFILYK

KIR3DX1

141

Q9H7L2
YREALEHLCTYEKQI

NAA15

206

Q9BXJ9
EEYHRICELLSDYKE

POTEE

466

Q6S8J3
AYCEDRVIEHYKKLN

FRMD4A

181

Q9P2Q2
YCEDRVIEHYLKIKG

FRMD4B

221

Q9Y2L6
LAYCLVHYRGDEKIK

CHD9

1536

Q3L8U1
QILTSYLREEHLYCI

GPATCH11

246

Q8N954
SDSYVYCLERKSHLL

KLRF1

136

Q9NZS2
CSKIYHISLEYVKRI

PCIF1

361

Q9H4Z3
IRYLYKLRDLHLDCD

DOCK2

1221

Q92608
TTLSDDIHELYVYKC

DOCK3

536

Q8IZD9
KEYVCRGHDYERLEA

DOCK3

1371

Q8IZD9
DHCEALYKEVQRCYL

GIMAP2

86

Q9UG22
DELKRLLYDTFCEHL

CABP7

131

Q86V35
HTVLDRQLLCLIDYY

CEP70

206

Q8NHQ1
IAKRAHREVDYLFCL

GBGT1

191

Q8N5D6
RSVEDLKERYYHICA

DMAP1

186

Q9NPF5
YHTLEEAKEYIRCHR

C19orf44

626

Q9H6X5
ISCYKGHREIARYLL

FEM1A

156

Q9BSK4
IRCKDDEFTHLYTLI

CALR

161

P27797
CRLYGYLIEKNAHES

MDH1B

236

Q5I0G3
YCKLYEHLQRAGSEL

CUL9

1501

Q8IWT3
HYAVLADDYRTVKEL

CLPB

271

Q9H078
ITCLERASHYLKTEY

DCBLD1

156

Q8N8Z6
ECYRDDHQKLSYKLV

FOCAD

391

Q5VW36
YHGIEYCLDDRKALE

MTBP

656

Q96DY7
CAVLEAKYLREFHSV

NAP1L6P

61

A6NFF2
LLKDIHVTSCVYYKE

MAP3K15

231

Q6ZN16
RYEKHYSVCAEILDQ

SPEF2

421

Q9C093
CERLLLYLYCHELSI

TRIM33

966

Q9UPN9
KCLYERQVDCSHTLY

TRIM36

686

Q9NQ86
ELDKSARHLYICDYH

SAP30

101

O75446
LIALYCLKELERSYH

SAMD9L

991

Q8IVG5
NAEKLCTLYEERLHE

MYH15

1256

Q9Y2K3
YRRGCLHKDIYALIS

EPPK1

2031

P58107
YHRICELVSDYKEKQ

POTEJ

431

P0CG39
ECVLKLISLRHYYFT

SCN9A

1561

Q15858
SEIYEHIHCLYKLSD

MSH4

601

O15457
EEYHRICELVSDYKE

POTEI

466

P0CG38
ALEHYTDLYDIKRAV

CLTCL1

626

P53675
GSCLEDLARKDYHYL

ZCCHC2

131

Q9C0B9
YIIHYIDDILCAAET

ERVK-25

191

P63136
LLLVHERYEQICEFY

ZNF618

701

Q5T7W0
YELHLSVKDYCFARE

UNC13C

2131

Q8NB66
CSEYLKYLLDRLHEE

USP35

521

Q9P2H5
RACVHVYKVLELYEE

VPS18

711

Q9P253
YIIHYIDDILCAAET

ERVK-10

191

P10266
YIIHYIDDILCAAET

ERVK-8

191

P63133
CRLVKYDEFHDYLER

USP47

656

Q96K76
YIIHYIDDILCAAET

ERVK-11

191

Q9UQG0
REKLHYYCEDDGKLL

TRIM26

106

Q12899
HGKRLVCYDDRYIVK

ZC3H12D

171

A2A288
IYHRNRLGEKLYECS

ZNF84

196

P51523
EDTVLDLVDYCHRKL

ZMYND10

131

O75800
VREKFSDCYIIHYID

ERVK-19

186

Q9WJR5
YLHAGIVSKSYECRL

ZNF407

1806

Q9C0G0
AEEYLHYLSERDACK

TSNAXIP1

181

Q2TAA8
RFTYDHAELERKIAC

FLT1

1306

P17948
HLRYYKTGICIHETD

UNK

121

Q9C0B0
TYKEYIDNRRLHIGC

ARHGAP21

391

Q5T5U3
EICDKYHIIHADIYR

MARS1

331

P56192
DFILSHAVYCRDVLK

UGGT1

871

Q9NYU2
YIKEHTRDKTYECNE

ZNF487

276

B1APH4
HYASAKVCEEKLRYA

HECTD3

831

Q5T447
KYLRGYHKCTREEVL

MYO7A

2021

Q13402
AKRCQYILSDLEYRH

NEB

4556

P20929