Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone modifying activity	UHRF1 EED KAT2A NSD3	6.67e-04	229	35	4	GO:0140993
GeneOntologyMolecularFunction	unfolded protein binding	DNAJB4 CCAR2 DNAJB11	1.39e-03	126	35	3	GO:0051082
GeneOntologyMolecularFunction	ATPase regulator activity	DNAJB4 CCAR2	4.03e-03	54	35	2	GO:0060590
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	DNAJB4 UHRF1 CCAR2 ZNF469 EED KAT2A MAGED4 NSD3 HMG20A RSF1	7.64e-05	1399	35	10	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	DNAJB4 UHRF1 CCAR2 ZNF469 EED KAT2A MAGED4 NSD3 HMG20A RSF1	8.31e-05	1413	35	10	GO:1902679
GeneOntologyCellularComponent	nuclear speck	DGKZ PRPF40B HECTD1 NXF1 GRK5 DDX42	7.25e-05	431	35	6	GO:0016607
GeneOntologyCellularComponent	U2-type prespliceosome	PRPF40B DDX42	4.10e-04	18	35	2	GO:0071004
GeneOntologyCellularComponent	prespliceosome	PRPF40B DDX42	4.10e-04	18	35	2	GO:0071010
Domain	Liprin	PPFIA3 PPFIBP2	5.09e-05	6	35	2	IPR029515
Domain	SAM_2	PPFIA3 SASH3 PPFIBP2	7.07e-05	43	35	3	PF07647
Domain	HSP40/DnaJ_pept-bd	DNAJB4 DNAJB11	1.22e-04	9	35	2	IPR008971
Domain	DnaJ_C	DNAJB4 DNAJB11	1.22e-04	9	35	2	IPR002939
Domain	DnaJ_C	DNAJB4 DNAJB11	1.22e-04	9	35	2	PF01556
Domain	Znf_FYVE_PHD	UHRF1 RPH3AL NSD3 RSF1	1.60e-04	147	35	4	IPR011011
Domain	PHD	UHRF1 NSD3 RSF1	3.71e-04	75	35	3	PF00628
Domain	Znf_PHD-finger	UHRF1 NSD3 RSF1	4.32e-04	79	35	3	IPR019787
Domain	SAM	PPFIA3 SASH3 PPFIBP2	5.93e-04	88	35	3	SM00454
Domain	PHD	UHRF1 NSD3 RSF1	6.13e-04	89	35	3	SM00249
Domain	Znf_PHD	UHRF1 NSD3 RSF1	6.54e-04	91	35	3	IPR001965
Domain	ZF_PHD_2	UHRF1 NSD3 RSF1	7.42e-04	95	35	3	PS50016
Domain	SAM_DOMAIN	PPFIA3 SASH3 PPFIBP2	7.42e-04	95	35	3	PS50105
Domain	ZF_PHD_1	UHRF1 NSD3 RSF1	7.64e-04	96	35	3	PS01359
Domain	SAM	PPFIA3 SASH3 PPFIBP2	7.88e-04	97	35	3	IPR001660
Domain	-	PPFIA3 SASH3 PPFIBP2	1.02e-03	106	35	3	1.10.150.50
Domain	DnaJ_domain_CS	DNAJB4 DNAJB11	1.16e-03	27	35	2	IPR018253
Domain	SAM/pointed	PPFIA3 SASH3 PPFIBP2	1.35e-03	117	35	3	IPR013761
Domain	DEAD_ATP_HELICASE	DDX31 DDX42	1.53e-03	31	35	2	PS00039
Domain	RNA-helicase_DEAD-box_CS	DDX31 DDX42	1.74e-03	33	35	2	IPR000629
Domain	RNA_helicase_DEAD_Q_motif	DDX31 DDX42	2.18e-03	37	35	2	IPR014014
Domain	Q_MOTIF	DDX31 DDX42	2.18e-03	37	35	2	PS51195
Domain	DnaJ	DNAJB4 DNAJB11	3.65e-03	48	35	2	PF00226
Domain	DnaJ	DNAJB4 DNAJB11	3.80e-03	49	35	2	SM00271
Domain	DNAJ_1	DNAJB4 DNAJB11	3.80e-03	49	35	2	PS00636
Domain	DNAJ_2	DNAJB4 DNAJB11	3.80e-03	49	35	2	PS50076
Domain	-	DNAJB4 DNAJB11	3.80e-03	49	35	2	1.10.287.110
Domain	DnaJ_domain	DNAJB4 DNAJB11	4.11e-03	51	35	2	IPR001623
Domain	Zinc_finger_PHD-type_CS	NSD3 RSF1	6.59e-03	65	35	2	IPR019786
Domain	SAM_1	PPFIA3 PPFIBP2	7.19e-03	68	35	2	PF00536
Domain	DEAD	DDX31 DDX42	8.25e-03	73	35	2	PF00270
Domain	DEAD/DEAH_box_helicase_dom	DDX31 DDX42	8.25e-03	73	35	2	IPR011545
Domain	-	UHRF1 RPH3AL NSD3 RSF1	9.57e-03	449	35	4	3.30.40.10
Domain	Znf_RING/FYVE/PHD	UHRF1 RPH3AL NSD3 RSF1	1.03e-02	459	35	4	IPR013083
Pathway	REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE	CHAT PPFIA3	4.37e-04	17	26	2	M93
Pathway	REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE	CHAT PPFIA3	4.37e-04	17	26	2	MM14907
Pathway	REACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES	PPFIA3 PPFIBP2	6.09e-04	20	26	2	M27290
Pathway	REACTOME_RECEPTOR_TYPE_TYROSINE_PROTEIN_PHOSPHATASES	PPFIA3 PPFIBP2	6.09e-04	20	26	2	MM14991
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DNAJB4 UHRF1 CCAR2 EED KAT2A NXF1 NSD3 HMG20A DDX42 RSF1	5.42e-08	1014	36	10	32416067
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CCAR2 SSB DDX31 HECTD1 CCDC86 NXF1 DDX42 RSF1	2.82e-07	653	36	8	22586326
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	UHRF1 CCAR2 SSB EED DDX31 HECTD1 CCDC86 NXF1	8.74e-07	759	36	8	35915203
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	UHRF1 EED DDX31 CCDC86 NSD3 HMG20A RSF1	2.59e-06	608	36	7	36089195
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	DNAJB11 ZNF469 KAT2A PPFIA3 PRPF40B NSD3 HMG20A RSF1	1.49e-05	1116	36	8	31753913
Pubmed	Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.	DGKZ KAT2A	1.56e-05	6	36	2	17664281
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	MRPS9 CCAR2 SSB DDX31 CCDC86 NXF1 DDX42	1.64e-05	807	36	7	22681889
Pubmed	ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.	UHRF1 EED NSD3 RSF1	1.76e-05	150	36	4	28242625
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	UHRF1 EED KAT2A CCDC86 NXF1 NSD3 HMG20A DDX42	4.29e-05	1294	36	8	30804502
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	UHRF1 SSB CCDC86 NSD3 HMG20A	5.14e-05	394	36	5	27248496
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	MRPS9 UHRF1 CCAR2 DDX31 CCDC86 NXF1 DDX42	5.98e-05	989	36	7	36424410
Pubmed	Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.	PPFIA3 PPFIBP2	6.83e-05	12	36	2	9624153
Pubmed	Human transcription factor protein interaction networks.	MRPS9 CCAR2 SSB KAT2A DDX31 CCDC86 NXF1 HMG20A	8.62e-05	1429	36	8	35140242
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PSD3 CCAR2 DNAJB11 DDX31 PPFIA3 CCDC86 NSD3	8.64e-05	1049	36	7	27880917
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	UHRF1 CCAR2 EED HMG20A RSF1	1.17e-04	469	36	5	27634302
Pubmed	Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.	UHRF1 RSF1	1.24e-04	16	36	2	28803780
Pubmed	Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.	DNAJB4 CCAR2 NSD3	1.32e-04	95	36	3	29490077
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	UHRF1 CCDC86 NSD3 HMG20A RSF1	2.11e-04	533	36	5	30554943
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	DNAJB4 HECTD1 CCDC86 NXF1	2.12e-04	285	36	4	32838362
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	DNAJB11 SSB MAGED4 HECTD1 NXF1	2.13e-04	534	36	5	35032548
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	MRPS9 SSB DDX31 CCDC86 NSD3 DDX42	2.14e-04	847	36	6	35850772
Pubmed	Noncoding RNA MaIL1 is an integral component of the TLR4-TRIF pathway.	CCAR2 DDX42	2.38e-04	22	36	2	32241891
Pubmed	Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature.	DNAJB4 DNAJB11	2.38e-04	22	36	2	11147971
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	MRPS9 SSB DDX31 HECTD1 NXF1	2.38e-04	547	36	5	37267103
Pubmed	Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation.	MRPS9 UHRF1 CCDC86	3.64e-04	134	36	3	28695742
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	EED CCDC86 HMG20A RSF1	3.69e-04	330	36	4	33301849
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	MRPS9 CCAR2 SSB HECTD1 CCDC86 NXF1 HMG20A	3.80e-04	1335	36	7	29229926
Pubmed	SIRT1 coordinates with the CRL4B complex to regulate pancreatic cancer stem cells to promote tumorigenesis.	CCAR2 EED	3.87e-04	28	36	2	34163012
Pubmed	hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.	MRPS9 CCAR2 SSB NXF1	4.41e-04	346	36	4	25324306
Pubmed	Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation.	CHAT EED	4.45e-04	30	36	2	29137925
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	CCAR2 DDX31 CCDC86 RSF1	4.56e-04	349	36	4	25665578
Pubmed	Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.	DNAJB4 CCAR2 DNAJB11	4.58e-04	145	36	3	28846114
Pubmed	Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.	KATNIP KAT2A PPFIBP2	4.96e-04	149	36	3	22664934
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	EED CCDC86 PPFIBP2 NXF1	5.17e-04	361	36	4	26167880
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	CCAR2 ZNF469 SSB DDX42 RSF1	5.35e-04	653	36	5	33742100
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	MRPS9 UHRF1 CCAR2 SSB CCDC86 NXF1 DDX42	5.61e-04	1425	36	7	30948266
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	UHRF1 EED KAT2A	5.78e-04	157	36	3	30186101
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	UHRF1 CCAR2 DNAJB11 CCDC86 NXF1 DDX42	5.87e-04	1024	36	6	24711643
Pubmed	A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.	CCAR2 KAT2A	6.07e-04	35	36	2	23382074
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	SSB NXF1 RSF1	6.44e-04	163	36	3	22113938
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PSD3 MRPS9 DNAJB4 DNAJB11 EED DDX31 DDX42	7.23e-04	1487	36	7	33957083
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	MRPS9 DNAJB11 NXF1 GRK5 DDX42	7.37e-04	701	36	5	30196744
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	DGKZ KAT2A DDX31 CCDC86 NXF1 NSD3 HMG20A	7.52e-04	1497	36	7	31527615
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DNAJB11 CCDC86 NXF1 NSD3 HMG20A DDX42	7.83e-04	1082	36	6	38697112
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	MRPS9 CCAR2 SSB DDX31 NXF1	7.95e-04	713	36	5	29802200
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PSD3 CCAR2 KATNIP SLC23A2	8.10e-04	407	36	4	12693553
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	UHRF1 DDX31 CCDC86 NXF1	8.32e-04	410	36	4	26949251
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	CCAR2 NXF1	9.59e-04	44	36	2	26471122
Interaction	H2BC8 interactions	UHRF1 EED DDX31 CCDC86 NXF1 NSD3 HMG20A DDX42 RSF1	5.65e-07	576	36	9	int:H2BC8
Interaction	H3C1 interactions	MRPS9 UHRF1 SSB EED KAT2A DDX31 NXF1 NSD3 DDX42 RSF1	2.67e-06	901	36	10	int:H3C1
Interaction	H2BC21 interactions	UHRF1 SSB EED KAT2A SASH3 CCDC86 NSD3 HMG20A RSF1	2.71e-06	696	36	9	int:H2BC21
Interaction	SUPT16H interactions	UHRF1 SSB EED HECTD1 NXF1 HMG20A RSF1	1.12e-05	442	36	7	int:SUPT16H
Interaction	YWHAZ interactions	PSD3 DNAJB4 CCAR2 KATNIP EED PPFIA3 HECTD1 PPFIBP2 NXF1 GRK5 RSF1	1.19e-05	1319	36	11	int:YWHAZ
Interaction	SNRNP40 interactions	CCAR2 DDX31 PRPF40B HECTD1 NXF1 NSD3 HMG20A RSF1	1.32e-05	637	36	8	int:SNRNP40
Interaction	RPL27A interactions	MRPS9 CCAR2 SSB EED DDX31 HECTD1 CCDC86	1.43e-05	459	36	7	int:RPL27A
Interaction	H3C3 interactions	UHRF1 EED DDX31 CCDC86 NSD3 HMG20A RSF1	2.33e-05	495	36	7	int:H3C3
Interaction	SIRT7 interactions	CCAR2 SSB DDX31 HECTD1 CCDC86 NXF1 DDX42 RSF1	4.01e-05	744	36	8	int:SIRT7
Interaction	KANK1 interactions	PPFIBP2 NXF1 GRK5	4.94e-05	40	36	3	int:KANK1
Interaction	KRR1 interactions	SSB EED DDX31 HECTD1 CCDC86 NXF1	5.14e-05	379	36	6	int:KRR1
Interaction	PARP1 interactions	MRPS9 UHRF1 CCAR2 EED DDX31 HECTD1 NXF1 NSD3 HMG20A RSF1	7.23e-05	1316	36	10	int:PARP1
Interaction	RCL1 interactions	EED HECTD1 NXF1 DDX42	7.35e-05	126	36	4	int:RCL1
Interaction	H2BC3 interactions	UHRF1 SSB KAT2A CCDC86 NSD3 HMG20A	7.52e-05	406	36	6	int:H2BC3
Interaction	ALYREF interactions	MRPS9 UHRF1 EED HECTD1 NXF1 GRK5	8.60e-05	416	36	6	int:ALYREF
Interaction	URB1 interactions	DGKZ EED HECTD1 NXF1	9.61e-05	135	36	4	int:URB1
Interaction	MYCN interactions	MRPS9 UHRF1 CCAR2 DNAJB11 SSB EED DDX31 CCDC86 GRK5 HMG20A	1.03e-04	1373	36	10	int:MYCN
Interaction	NFIB interactions	EED NXF1 GRK5 HMG20A	1.17e-04	142	36	4	int:NFIB
Interaction	TLX2 interactions	MRPS9 CCAR2 CCDC86 HMG20A	1.17e-04	142	36	4	int:TLX2
Interaction	SUZ12 interactions	UHRF1 CCAR2 SSB EED HECTD1 NXF1 HMG20A	1.23e-04	644	36	7	int:SUZ12
Interaction	ZNF330 interactions	UHRF1 SSB DDX31 NSD3 HMG20A RSF1	1.26e-04	446	36	6	int:ZNF330
Interaction	PRPF19 interactions	DNAJB11 SSB EED HECTD1 NXF1 DDX42	1.32e-04	450	36	6	int:PRPF19
Interaction	NOC2L interactions	DGKZ EED DDX31 HECTD1 NXF1	1.37e-04	282	36	5	int:NOC2L
Interaction	EIF3H interactions	SSB EED HECTD1 HMG20A RSF1	1.37e-04	282	36	5	int:EIF3H
Interaction	MACROH2A1 interactions	UHRF1 EED HECTD1 NXF1 NSD3 RSF1	1.46e-04	458	36	6	int:MACROH2A1
Interaction	USP18 interactions	CCAR2 NXF1 RSF1	1.67e-04	60	36	3	int:USP18
Interaction	RSL1D1 interactions	SSB EED DDX31 HECTD1 CCDC86 NXF1	1.86e-04	479	36	6	int:RSL1D1
Interaction	PPIL4 interactions	CCAR2 HECTD1 NXF1 DDX42	2.08e-04	165	36	4	int:PPIL4
Interaction	BRD3 interactions	UHRF1 PRPF40B CCDC86 NSD3 HMG20A RSF1	2.19e-04	494	36	6	int:BRD3
Interaction	DDX21 interactions	CCAR2 SSB EED DDX31 HECTD1 CCDC86 GRK5	2.40e-04	718	36	7	int:DDX21
Interaction	RBM25 interactions	EED PRPF40B HECTD1 NXF1 DDX42	2.57e-04	323	36	5	int:RBM25
Interaction	PPFIBP1 interactions	PPFIA3 PPFIBP2 NXF1 GRK5	2.72e-04	177	36	4	int:PPFIBP1
Interaction	H2AC8 interactions	UHRF1 CCDC86 NXF1 RSF1	2.72e-04	177	36	4	int:H2AC8
Interaction	RTL6 interactions	PPFIBP2 NXF1	2.79e-04	14	36	2	int:RTL6
Interaction	HECTD1 interactions	UHRF1 CCAR2 SSB EED DDX31 HECTD1 CCDC86 NXF1	2.80e-04	984	36	8	int:HECTD1
Interaction	SNRNP70 interactions	MRPS9 CCAR2 SSB EED DDX31 HECTD1 PLEKHG7 NXF1	2.80e-04	984	36	8	int:SNRNP70
Interaction	CCDC71 interactions	SSB EED NSD3	2.87e-04	72	36	3	int:CCDC71
Interaction	TGS1 interactions	DNAJB4 SSB EED	3.24e-04	75	36	3	int:TGS1
Interaction	TPT1 interactions	DNAJB4 CCAR2 DNAJB11 EED CCDC86	3.48e-04	345	36	5	int:TPT1
Interaction	FAM200C interactions	EED NXF1	3.66e-04	16	36	2	int:FAM200C
Interaction	ASCC3 interactions	DGKZ EED HECTD1 NXF1	3.85e-04	194	36	4	int:ASCC3
Interaction	KLF12 interactions	MRPS9 SSB KAT2A DDX31	3.85e-04	194	36	4	int:KLF12
Interaction	CDX1 interactions	MRPS9 CCDC86 DDX42	3.91e-04	80	36	3	int:CDX1
Interaction	RBM39 interactions	MRPS9 CCAR2 DNAJB11 SSB EED HECTD1 NXF1 DDX42	4.12e-04	1042	36	8	int:RBM39
Interaction	MRTO4 interactions	EED HECTD1 CCDC86 GRK5	4.32e-04	200	36	4	int:MRTO4
Interaction	CAPZA1 interactions	DGKZ DNAJB11 SSB EED NXF1	4.56e-04	366	36	5	int:CAPZA1
Interaction	SRSF1 interactions	MRPS9 EED DDX31 CCDC86 NXF1 GRK5	4.71e-04	570	36	6	int:SRSF1
Interaction	NOP56 interactions	SSB EED DDX31 HECTD1 CCDC86 NXF1	4.71e-04	570	36	6	int:NOP56
Interaction	DROSHA interactions	EED HECTD1 NXF1	5.01e-04	87	36	3	int:DROSHA
Interaction	DDX42 interactions	DNAJB11 EED NXF1 DDX42	5.01e-04	208	36	4	int:DDX42
Interaction	WDR36 interactions	DGKZ HECTD1 PLEKHG7 NXF1	5.01e-04	208	36	4	int:WDR36
Interaction	MAILR interactions	CCAR2 DDX42	5.20e-04	19	36	2	int:MAILR
Interaction	CENPA interactions	UHRF1 DDX31 NSD3 HMG20A RSF1	5.22e-04	377	36	5	int:CENPA
Interaction	XRN2 interactions	MRPS9 CCAR2 EED HECTD1 NXF1	5.47e-04	381	36	5	int:XRN2
Interaction	NOL6 interactions	DGKZ EED HECTD1 NXF1	5.48e-04	213	36	4	int:NOL6
Interaction	H2AX interactions	UHRF1 SSB KAT2A CCDC86 HMG20A RSF1	5.81e-04	593	36	6	int:H2AX
Interaction	BMS1 interactions	DGKZ HECTD1 NXF1 GRK5	5.98e-04	218	36	4	int:BMS1
Interaction	NUCKS1 interactions	UHRF1 EED HMG20A RSF1	6.19e-04	220	36	4	int:NUCKS1
Interaction	CPSF4 interactions	EED HECTD1 NXF1	6.28e-04	94	36	3	int:CPSF4
Interaction	DKC1 interactions	SSB EED DDX31 HECTD1 NXF1	6.30e-04	393	36	5	int:DKC1
Interaction	ARHGEF10 interactions	DNAJB11 HECTD1 PLEKHG7	6.47e-04	95	36	3	int:ARHGEF10
Interaction	RPL23A interactions	SSB EED DDX31 HECTD1 CCDC86 DDX42	6.51e-04	606	36	6	int:RPL23A
Interaction	EXOSC10 interactions	SSB EED HECTD1 NXF1	6.51e-04	223	36	4	int:EXOSC10
Interaction	OASL interactions	CCAR2 DNAJB11 SSB CCDC86	6.51e-04	223	36	4	int:OASL
Interaction	NSA2 interactions	MRPS9 EED HECTD1 CCDC86	6.73e-04	225	36	4	int:NSA2
Interaction	NLE1 interactions	DDX31 HECTD1 CCDC86 RSF1	7.07e-04	228	36	4	int:NLE1
Interaction	RUVBL2 interactions	DNAJB4 CCAR2 EED HECTD1 NXF1 DDX42	7.09e-04	616	36	6	int:RUVBL2
Interaction	TUBGCP3 interactions	SSB EED HECTD1 NXF1	7.19e-04	229	36	4	int:TUBGCP3
Interaction	RPS6KA4 interactions	EED PLEKHG7 DDX42	7.52e-04	100	36	3	int:RPS6KA4
Interaction	H2AC17 interactions	MRPS9 DDX31 CCDC86 HMG20A	7.55e-04	232	36	4	int:H2AC17
Interaction	CAPN6 interactions	EED HECTD1	7.67e-04	23	36	2	int:CAPN6
Interaction	RBM15B interactions	HECTD1 NXF1 DDX42	7.74e-04	101	36	3	int:RBM15B
Interaction	RPS6 interactions	MRPS9 SSB EED DDX31 CCDC86 NSD3 RSF1	7.81e-04	874	36	7	int:RPS6
Interaction	NUP205 interactions	EED TTBK1 HECTD1 NXF1	7.92e-04	235	36	4	int:NUP205
Interaction	CIT interactions	UHRF1 CCAR2 SSB EED DDX31 CCDC86 MYO1H DDX42 RSF1	8.02e-04	1450	36	9	int:CIT
Interaction	SMARCA5 interactions	UHRF1 EED KAT2A HECTD1 RSF1	8.05e-04	415	36	5	int:SMARCA5
Interaction	AFG2B interactions	HECTD1 PLEKHG7 NXF1	8.19e-04	103	36	3	int:AFG2B
Interaction	HMGA1 interactions	UHRF1 SSB EED HMG20A RSF1	8.41e-04	419	36	5	int:HMGA1
Interaction	FBL interactions	SSB EED DDX31 HECTD1 CCDC86 NXF1	8.59e-04	639	36	6	int:FBL
Interaction	LIN28A interactions	MRPS9 SSB EED DDX31 CCDC86	8.59e-04	421	36	5	int:LIN28A
Interaction	PNPLA6 interactions	EED NXF1 GRK5	8.66e-04	105	36	3	int:PNPLA6
Interaction	RAD51 interactions	HECTD1 NXF1 NSD3 HMG20A	8.70e-04	241	36	4	int:RAD51
Interaction	EXOC2 interactions	EED HECTD1 NXF1	8.90e-04	106	36	3	int:EXOC2
Interaction	KLF16 interactions	MRPS9 CCAR2 SSB DDX31 NXF1	8.96e-04	425	36	5	int:KLF16
Interaction	ILF3 interactions	MRPS9 SSB EED DDX31 CCDC86 NXF1 GRK5	9.04e-04	896	36	7	int:ILF3
Interaction	SURF6 interactions	MRPS9 DDX31 HECTD1 CCDC86 NXF1	9.06e-04	426	36	5	int:SURF6
Interaction	CBX3 interactions	UHRF1 SSB EED NSD3 DDX42 RSF1	9.09e-04	646	36	6	int:CBX3
Interaction	KIF20B interactions	DGKZ EED HECTD1	9.15e-04	107	36	3	int:KIF20B
Interaction	DDX51 interactions	DGKZ EED HECTD1	9.40e-04	108	36	3	int:DDX51
Interaction	KIF4A interactions	EED HECTD1 NXF1	9.40e-04	108	36	3	int:KIF4A
Interaction	U2AF2 interactions	MRPS9 SSB EED HECTD1 NXF1 DDX42	9.46e-04	651	36	6	int:U2AF2
Interaction	MACF1 interactions	SSB EED HECTD1 NXF1	9.53e-04	247	36	4	int:MACF1
Interaction	RPS5 interactions	MRPS9 SSB EED HECTD1 NXF1	9.54e-04	431	36	5	int:RPS5
Interaction	NIFK interactions	SSB EED DDX31 HECTD1 CCDC86	9.54e-04	431	36	5	int:NIFK
Interaction	PSMD2 interactions	CCAR2 EED HECTD1 NXF1 GRK5	9.94e-04	435	36	5	int:PSMD2
Interaction	PTGES3 interactions	UHRF1 DGKZ EED KAT2A MAGED4	1.01e-03	437	36	5	int:PTGES3
Interaction	HJURP interactions	EED HECTD1 NXF1	1.02e-03	111	36	3	int:HJURP
Interaction	DHX9 interactions	SSB EED HECTD1 NXF1 GRK5 NSD3	1.03e-03	662	36	6	int:DHX9
Interaction	RANBP3 interactions	DNAJB4 SGSM1 NXF1	1.04e-03	112	36	3	int:RANBP3
Interaction	NPM1 interactions	MRPS9 DNAJB4 SSB EED DDX31 HECTD1 CCDC86 NXF1	1.05e-03	1201	36	8	int:NPM1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q14	FZD4 EED RSF1	2.53e-04	156	36	3	chr11q14
GeneFamily	Sterile alpha motif domain containing	PPFIA3 SASH3 PPFIBP2	2.37e-04	88	25	3	760
GeneFamily	PHD finger proteins	UHRF1 NSD3 RSF1	2.53e-04	90	25	3	88
GeneFamily	DEAD-box helicases	DDX31 DDX42	1.53e-03	42	25	2	499
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJB4 DNAJB11	2.07e-03	49	25	2	584
Drug	Rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A	PSD3 DDX31 PPFIA3 CCDC86 TAT GRK5	5.41e-07	193	36	6	5239_DN
Drug	lomustine; Up 200; 100uM; MCF7; HT_HG-U133A	DNAJB4 KAT2A PPFIA3 SLC23A2 NSD3	1.03e-05	185	36	5	7089_UP
Drug	Deptropine citrate [2169-75-7]; Down 200; 7.6uM; MCF7; HT_HG-U133A	PSD3 DNAJB4 KATNIP PPFIA3 PPFIBP2	1.43e-05	198	36	5	6523_DN
Disease	venous thromboembolism, tissue plasminogen activator measurement	DGKZ GRK5	3.21e-04	23	34	2	EFO_0004286, EFO_0004791
Disease	blood tin measurement	PSD3 CHAT	3.80e-04	25	34	2	EFO_0021530
Disease	Retinal Diseases	FZD4 CHAT	4.44e-04	27	34	2	C0035309
Disease	factor XI measurement, venous thromboembolism	DGKZ GRK5	5.49e-04	30	34	2	EFO_0004286, EFO_0004694
Disease	factor VIII measurement, venous thromboembolism	DGKZ GRK5	7.06e-04	34	34	2	EFO_0004286, EFO_0004630
Disease	glucose measurement	PSD3 SGSM1 PPFIBP2 HMG20A	9.25e-04	380	34	4	EFO_0004468
Disease	venous thromboembolism, von Willebrand factor measurement	DDX31 GRK5	1.08e-03	42	34	2	EFO_0004286, EFO_0004629
Disease	cutaneous melanoma, hair color	DNAJB4 PPFIBP2	2.33e-03	62	34	2	EFO_0000389, EFO_0003924
Disease	venous thromboembolism, fibrinogen measurement	DGKZ GRK5	2.72e-03	67	34	2	EFO_0004286, EFO_0004623
Disease	axial length measurement	ZNF469 HMG20A	3.57e-03	77	34	2	EFO_0005318
Disease	exploratory eye movement measurement	CCAR2 PLEKHG7	3.94e-03	81	34	2	EFO_0007700
Disease	migraine disorder, Headache	DGKZ MYO1H	4.43e-03	86	34	2	HP_0002315, MONDO_0005277
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement	PSD3 MYO1H	6.65e-03	106	34	2	EFO_0008317, EFO_0008596
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	PSD3 MYO1H	7.15e-03	110	34	2	EFO_0008317, EFO_0008591, EFO_0008596

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKRKQRAGGEPWGAK	CCAR2	201	Q8N163
PKGKPKSGRVWKDRS	CCDC86	236	Q9H6F5
IRETGWKPLGKEKGK	KAT2A	711	Q92830
EPWARMGGKRTKKSK	MAGED4	336	Q96JG8
PGKMKGRKARWSVRP	TAT	31	P17735
LNKWKSKGRRFKGKG	SSB	326	P05455
GWSKGRKRKKPLRDS	HMG20A	86	Q9NP66
GKDRKQGGRKPKPLW	KATNIP	761	O60303
GKRGRWSGVKEEPSK	PPFIA3	541	O75145
AWFRKSRFKGGKGKK	DDX42	636	Q86XP3
RKKKGRGPFRWKYGE	NXF1	21	Q9UBU9
NAPGRKSWGKGKWKS	EED	61	O75530
FGRGKTLKWRKTQKG	DDX31	826	Q9H8H2
PDGKRNPKGIKKFWG	PPFIBP2	491	Q8ND30
NPKGIKKFWGKIRRT	PPFIBP2	496	Q8ND30
KVKREKRGNGWVKPG	FZD4	516	Q9ULV1
KGWKEGTKITFPREG	DNAJB4	206	Q9UDY4
VTGWTGKRGRKLKSK	HECTD1	811	Q9ULT8
KITRPGAKLWKKGEG	DNAJB11	291	Q9UBS4
FKRKSSKKGPEEGRW	DGKZ	266	Q13574
REGGGGKRKGKSKKW	GRK5	16	P34947
KVKPKGKVRWTGSRT	RSF1	836	Q96T23
GKSGKKLGKKWRAVI	SASH3	66	O75995
PSTGVRDRKGDKPWK	RPH3AL	226	Q9UNE2
THRKPGKLASWRGGK	SPATA31E1	801	Q6ZUB1
AKKRGLGGGGKWKRE	CHAT	6	P28329
KDRWKVLKKIGGGGF	TTBK1	31	Q5TCY1
KPGQEGARRKFTWKK	MRPS9	381	P82933
PEERGIRKWKKGVGK	SLC23A2	576	Q9UGH3
RSPGFGIKKEKTGWD	PRPF40B	831	Q6NWY9
WSQRGKGKVFPKLRK	SGSM1	381	Q2NKQ1
GWGLRTKRSIKKGEF	NSD3	1156	Q9BZ95
PRKRKARGGAWGKEL	ZNF469	1036	Q96JG9
GFASPRTGKGKWKRK	UHRF1	636	Q96T88
SKKPRWPFSKRGVGK	PLEKHG7	221	Q6ZR37
DGKKTPRGKRGWKTF	PSD3	801	Q9NYI0
RKLAGPKGRKRIGWM	MYO1H	496	Q8N1T3