Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP-dependent activity

SPG7 DNAH10 DNAH17 AACS MYO18A SMARCA2 SMARCA4 SRP54 RFC1 YME1L1 ABCA10 ATP4A

3.40e-076146212GO:0140657
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

SPG7 DNAH10 RRAGA MYO18A SMARCA4 SRP54 RRAGB RFC1 YME1L1 ABCA10 ATP4A ARF6

3.89e-067756212GO:0017111
GeneOntologyMolecularFunctionATP hydrolysis activity

SPG7 DNAH10 MYO18A SMARCA4 SRP54 RFC1 YME1L1 ABCA10 ATP4A

8.29e-06441629GO:0016887
GeneOntologyMolecularFunctionpyrophosphatase activity

SPG7 DNAH10 RRAGA MYO18A SMARCA4 SRP54 RRAGB RFC1 YME1L1 ABCA10 ATP4A ARF6

8.71e-068396212GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

SPG7 DNAH10 RRAGA MYO18A SMARCA4 SRP54 RRAGB RFC1 YME1L1 ABCA10 ATP4A ARF6

8.82e-068406212GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

SPG7 DNAH10 RRAGA MYO18A SMARCA4 SRP54 RRAGB RFC1 YME1L1 ABCA10 ATP4A ARF6

8.82e-068406212GO:0016818
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

GBF1 SWAP70 CYTH3 CYTH2 CYTH1 AKAP13

8.04e-05231626GO:0005085
GeneOntologyMolecularFunctionATP-dependent peptidase activity

SPG7 YME1L1

2.62e-048622GO:0004176
GeneOntologyMolecularFunctionphosphatidylinositol-3,4,5-trisphosphate binding

GBF1 CYTH3 PARD3

4.74e-0449623GO:0005547
GeneOntologyMolecularFunctionATP-dependent activity, acting on DNA

MYO18A SMARCA2 SMARCA4 RFC1

6.55e-04127624GO:0008094
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

TBC1D9B GBF1 SWAP70 CYTH3 CYTH2 CYTH1 AKAP13

9.60e-04507627GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

TBC1D9B GBF1 SWAP70 CYTH3 CYTH2 CYTH1 AKAP13

9.60e-04507627GO:0030695
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH10 DNAH17

1.41e-0318622GO:0008569
GeneOntologyBiologicalProcessestablishment of epithelial cell polarity

CYTH3 CYTH1 MYO18A PARD3 ARF6

1.50e-0742615GO:0090162
GeneOntologyBiologicalProcessregulation of ARF protein signal transduction

GBF1 CYTH3 CYTH2 CYTH1

5.88e-0723614GO:0032012
GeneOntologyBiologicalProcessARF protein signal transduction

GBF1 CYTH3 CYTH2 CYTH1

7.04e-0724614GO:0032011
GeneOntologyBiologicalProcessendoplasmic reticulum-Golgi intermediate compartment organization

GBF1 STX17

8.60e-062612GO:0097111
GeneOntologyBiologicalProcessestablishment of cell polarity

GBF1 CYTH3 CYTH1 MYO18A PARD3 ARF6

1.38e-05177616GO:0030010
GeneOntologyBiologicalProcessmuscle cell differentiation

CFLAR NRAP HDAC6 SMARCA2 SMARCA4 LMOD1 AKAP13 TANC1 HNRNPU

2.45e-05531619GO:0042692
GeneOntologyBiologicalProcessregulation of organelle organization

TBC1D9B HDAC6 SWAP70 BST1 VPS13C SMARCA2 SMARCA4 LMOD1 AKAP13 SYT2 SNCA YME1L1 HNRNPU ARF6

2.84e-0513426114GO:0033043
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

GBF1 SWAP70 CYTH3 CYTH2 CYTH1 AKAP13 ARF6

5.54e-05333617GO:0051056
GeneOntologyBiologicalProcessactin filament-based process

CFLAR NRAP HDAC6 SWAP70 BST1 CYTH2 MYO18A LMOD1 AKAP13 PARD3 ARF6

6.54e-059126111GO:0030029
GeneOntologyBiologicalProcesscellular component disassembly

GBF1 HDAC6 SWAP70 VPS13C SMARCA4 LMOD1 STX17 CTSV ARF6

7.83e-05617619GO:0022411
GeneOntologyBiologicalProcessreactive oxygen species biosynthetic process

CYBB CFLAR GBF1 SNCA

9.26e-0580614GO:1903409
GeneOntologyBiologicalProcessestablishment or maintenance of cell polarity

GBF1 CYTH3 CYTH1 MYO18A PARD3 ARF6

1.10e-04257616GO:0007163
GeneOntologyBiologicalProcessactin cytoskeleton organization

CFLAR NRAP HDAC6 SWAP70 BST1 CYTH2 MYO18A LMOD1 AKAP13 ARF6

1.13e-048036110GO:0030036
GeneOntologyBiologicalProcessmyofibril assembly

CFLAR NRAP LMOD1 AKAP13

1.23e-0486614GO:0030239
GeneOntologyBiologicalProcessaortic smooth muscle cell differentiation

SMARCA2 SMARCA4

1.28e-046612GO:0035887
GeneOntologyBiologicalProcessstriated muscle cell development

CFLAR NRAP LMOD1 AKAP13

1.40e-0489614GO:0055002
GeneOntologyBiologicalProcessstriated muscle cell differentiation

CFLAR NRAP HDAC6 LMOD1 AKAP13 TANC1 HNRNPU

1.51e-04391617GO:0051146
GeneOntologyBiologicalProcesstype 2 mitophagy

HDAC6 VPS13C

1.79e-047612GO:0061734
GeneOntologyBiologicalProcessreactive oxygen species metabolic process

CYBB CFLAR GBF1 HDAC6 BST1 SNCA

2.17e-04291616GO:0072593
GeneOntologyBiologicalProcessresponse to corticosteroid

CYBB CFLAR HDAC6 AKAP13 HNRNPU

2.18e-04185615GO:0031960
GeneOntologyBiologicalProcessregulation of cytoskeleton organization

HDAC6 SWAP70 BST1 LMOD1 AKAP13 SNCA HNRNPU ARF6

2.92e-04579618GO:0051493
GeneOntologyBiologicalProcessnegative regulation of autophagy

HDAC6 RRAGA RRAGB SNCA

3.39e-04112614GO:0010507
GeneOntologyBiologicalProcessrRNA transcription

POLR1A SMARCA4 MACROH2A2

3.41e-0446613GO:0009303
GeneOntologyBiologicalProcessGolgi vesicle budding

GBF1 MYO18A

3.81e-0410612GO:0048194
GeneOntologyBiologicalProcessorganelle assembly

CFLAR TBC1D9B GBF1 NRAP HDAC6 DNAH17 TTC12 LMOD1 AKAP13 STX17 HNRNPU

4.51e-0411386111GO:0070925
GeneOntologyBiologicalProcessnegative regulation of dendrite development

CYTH2 ARF6

5.57e-0412612GO:2000171
GeneOntologyBiologicalProcessresponse to dexamethasone

CFLAR HDAC6 HNRNPU

5.79e-0455613GO:0071548
GeneOntologyBiologicalProcesscellular response to steroid hormone stimulus

CFLAR HDAC6 SMARCA4 AKAP13 HNRNPU

7.03e-04239615GO:0071383
GeneOntologyBiologicalProcessactomyosin structure organization

CFLAR NRAP MYO18A LMOD1 AKAP13

7.03e-04239615GO:0031032
GeneOntologyBiologicalProcesscellular response to nerve growth factor stimulus

MICALL1 CDC5L ARF6

7.11e-0459613GO:1990090
GeneOntologyCellularComponentGtr1-Gtr2 GTPase complex

RRAGA RRAGB

5.34e-054632GO:1990131
GeneOntologyCellularComponentbBAF complex

SMARCA2 SMARCA4

3.96e-0410632GO:0140092
GeneOntologyCellularComponentbicellular tight junction

CYTH3 CYTH2 CYTH1 PARD3

6.59e-04131634GO:0005923
GeneOntologyCellularComponentcytoplasmic region

HDAC6 SPG7 DNAH10 DNAH17 HNRNPU FABP2

7.44e-04360636GO:0099568
GeneOntologyCellularComponentnpBAF complex

SMARCA2 SMARCA4

7.95e-0414632GO:0071564
GeneOntologyCellularComponentGBAF complex

SMARCA2 SMARCA4

7.95e-0414632GO:0140288
GeneOntologyCellularComponenttight junction

CYTH3 CYTH2 CYTH1 PARD3

8.23e-04139634GO:0070160
GeneOntologyCellularComponentnBAF complex

SMARCA2 SMARCA4

1.04e-0316632GO:0071565
HumanPhenoAbnormality of peripheral nervous system electrophysiology

POLR1A SPG7 AFF3 SMARCA4 SYT2 RFC1 PLCH1 YME1L1

4.23e-05315238HP:0030177
HumanPhenoAbnormal peripheral nervous system physiology

POLR1A SPG7 AFF3 SMARCA4 SYT2 RFC1 PLCH1 YME1L1

4.63e-05319238HP:0032120
Domain-

GBF1 CYTH3 CYTH2 CYTH1

1.37e-07156141.10.1000.11
DomainSec7

GBF1 CYTH3 CYTH2 CYTH1

1.37e-0715614PF01369
DomainSec7_alpha_orthog

GBF1 CYTH3 CYTH2 CYTH1

1.37e-0715614IPR023394
DomainSec7

GBF1 CYTH3 CYTH2 CYTH1

1.82e-0716614SM00222
DomainSEC7

GBF1 CYTH3 CYTH2 CYTH1

1.82e-0716614PS50190
DomainSec7_dom

GBF1 CYTH3 CYTH2 CYTH1

1.82e-0716614IPR000904
Domain-

SPG7 DNAH10 RRAGA MYO18A SMARCA2 SMARCA4 SRP54 RRAGB RFC1 YME1L1 ABCA10 HNRNPU ARF6

6.62e-0774661133.40.50.300
DomainP-loop_NTPase

SPG7 DNAH10 RRAGA MYO18A SMARCA2 SMARCA4 SRP54 RRAGB RFC1 YME1L1 ABCA10 HNRNPU ARF6

2.76e-068486113IPR027417
DomainAAA+_ATPase

SPG7 DNAH10 SRP54 RFC1 YME1L1 ABCA10

7.41e-06144616IPR003593
DomainAAA

SPG7 DNAH10 SRP54 RFC1 YME1L1 ABCA10

7.41e-06144616SM00382
DomainSnAC

SMARCA2 SMARCA4

1.05e-052612SM01314
DomainGln-Leu-Gln_QLQ

SMARCA2 SMARCA4

1.05e-052612IPR014978
DomainSnAC

SMARCA2 SMARCA4

1.05e-052612IPR029295
DomainSnAC

SMARCA2 SMARCA4

1.05e-052612PF14619
DomainQLQ

SMARCA2 SMARCA4

1.05e-052612SM00951
DomainQLQ

SMARCA2 SMARCA4

1.05e-052612PS51666
DomainQLQ

SMARCA2 SMARCA4

1.05e-052612PF08880
DomainFtsH

SPG7 YME1L1

3.14e-053612IPR005936
DomainPeptidase_M41

SPG7 YME1L1

3.14e-053612IPR000642
DomainPeptidase_M41

SPG7 YME1L1

3.14e-053612PF01434
DomainHSA

SMARCA2 SMARCA4

6.27e-054612SM00573
DomainGtr1_RagA

RRAGA RRAGB

6.27e-054612PF04670
DomainGtr1_RagA

RRAGA RRAGB

6.27e-054612IPR006762
DomainHSA

SMARCA2 SMARCA4

6.27e-054612PS51204
DomainHSA_dom

SMARCA2 SMARCA4

6.27e-054612IPR014012
DomainHSA

SMARCA2 SMARCA4

6.27e-054612PF07529
DomainBRK

SMARCA2 SMARCA4

1.56e-046612SM00592
DomainBRK_domain

SMARCA2 SMARCA4

1.56e-046612IPR006576
DomainBRK

SMARCA2 SMARCA4

1.56e-046612PF07533
DomainPH

SWAP70 CYTH3 CYTH2 CYTH1 AKAP13 PLCH1

2.88e-04278616SM00233
DomainPH_DOMAIN

SWAP70 CYTH3 CYTH2 CYTH1 AKAP13 PLCH1

2.94e-04279616PS50003
DomainPH_domain

SWAP70 CYTH3 CYTH2 CYTH1 AKAP13 PLCH1

2.99e-04280616IPR001849
DomainAAA

SPG7 RFC1 YME1L1

6.54e-0452613PF00004
DomainATPase_AAA_core

SPG7 RFC1 YME1L1

7.30e-0454613IPR003959
DomainPH

SWAP70 CYTH3 CYTH2 CYTH1 AKAP13

9.03e-04229615PF00169
Domain-

SWAP70 CYTH3 CYTH2 CYTH1 AKAP13 PLCH1

1.70e-033916162.30.29.30
Domain-

CCAR1 HNRNPU

2.12e-03216121.10.720.30
DomainSAP

CCAR1 HNRNPU

2.32e-0322612PF02037
DomainSAP

CCAR1 HNRNPU

2.54e-0323612SM00513
DomainPH_dom-like

SWAP70 CYTH3 CYTH2 CYTH1 AKAP13 PLCH1

2.62e-03426616IPR011993
DomainSAP

CCAR1 HNRNPU

3.00e-0325612PS50800
DomainSAP_dom

CCAR1 HNRNPU

3.00e-0325612IPR003034
DomainBromodomain_CS

SMARCA2 SMARCA4

3.24e-0326612IPR018359
DomainSNF2_N

SMARCA2 SMARCA4

4.89e-0332612IPR000330
DomainSNF2_N

SMARCA2 SMARCA4

4.89e-0332612PF00176
DomainBROMODOMAIN_1

SMARCA2 SMARCA4

6.49e-0337612PS00633
PathwayBIOCARTA_ARAP_PATHWAY

GBF1 CYTH3 CYTH2 CYTH1

7.36e-0812514MM1342
PathwayBIOCARTA_ARAP_PATHWAY

GBF1 CYTH3 CYTH2 CYTH1

3.49e-0717514M2482
PathwayKEGG_MEDICUS_REFERENCE_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

CYTH3 CYTH2 CYTH1 ARF6

1.82e-0625514M47716
PathwayKEGG_MEDICUS_PATHOGEN_SHIGELLA_IPGD_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

CYTH3 CYTH2 CYTH1 ARF6

3.38e-0629514M47717
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

CYTH3 CYTH2 CYTH1 ARF6

3.88e-0630514M47738
PathwayWP_2Q37_COPY_NUMBER_VARIATION_SYNDROME

CFLAR RRAGA CYTH3 CYTH2 CYTH1 RRAGB

1.31e-05145516M45512
PathwayPID_PI3KCI_PATHWAY

CYTH3 CYTH2 CYTH1 ARF6

2.63e-0548514M141
PathwayPID_ARF6_PATHWAY

CYTH3 CYTH2 ARF6

2.69e-0435513M86
PathwayREACTOME_INTRA_GOLGI_TRAFFIC

CYTH3 CYTH2 CYTH1

3.18e-0437513MM15354
PathwayREACTOME_INTRA_GOLGI_TRAFFIC

CYTH3 CYTH2 CYTH1

5.32e-0444513M27652
Pubmed

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.

CYTH3 CYTH2 CYTH1 PARD3 ARF6

1.00e-12864520080746
Pubmed

A crucial role for Arf6 in the response of commissural axons to Slit.

GBF1 CYTH3 CYTH2 CYTH1 ARF6

2.05e-101964530674481
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

HDAC6 POLR1A ACLY SMARCA2 SMARCA4 CCAR1 SRP54 AKAP13 MACROH2A2 TANC1 RBM28 CDC5L RFC1 PARD3 YME1L1 AARSD1 HNRNPU

2.37e-101353641729467282
Pubmed

The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.

CYTH3 CYTH2 CYTH1 ARF6

7.26e-10864417398095
Pubmed

The N-terminal coiled-coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with Galphaq.

CYTH3 CYTH2 CYTH1 ARF6

1.30e-09964417846866
Pubmed

Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.

CYTH3 CYTH2 CYTH1

5.94e-09364318042453
Pubmed

Phagocytic NADPH oxidase links ARNO-Arf6 signaling pathway in glucose-stimulated insulin secretion from the pancreatic β-cell.

CYBB CYTH2 ARF6

5.94e-09364323095975
Pubmed

Complex regulation of multiple cytohesin-like genes in murine tissues and cells.

CYTH3 CYTH2 CYTH1

5.94e-0936439744817
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

POLR1A VPS13C ANKAR TTC12 AFF3 SMARCA2 CCAR1 SRP54 SRPK2 AKAP13 MACROH2A2 TANC1 SYT2 PARD3 STX17 HNRNPU

8.22e-091489641628611215
Pubmed

Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors.

CYTH3 CYTH2 CYTH1

2.37e-08464310652308
Pubmed

Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration.

CYTH3 CYTH2 CYTH1

2.37e-08464312606567
Pubmed

Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity.

CYTH3 CYTH2 CYTH1

5.93e-08564312920129
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

MICALL1 GBF1 POLR1A SWAP70 ACLY MYO18A CCAR1 SRP54 AKAP13 HMMR MXRA7

8.05e-08724641136232890
Pubmed

INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.

CYTH3 CYTH2 CYTH1

1.18e-07664330355448
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

POLR1A MYO18A SMARCA4 SRPK2 MACROH2A2 HMMR RBM28 CDC5L RFC1 YME1L1 HNRNPU

1.29e-07759641135915203
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

MICALL1 GBF1 HDAC6 ACLY MYO18A SMARCA2 SMARCA4 CCAR1 RFC1 PARD3 OTUD7B

1.57e-07774641115302935
Pubmed

C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions.

CYTH3 CYTH2 CYTH1 ARF6

1.77e-072764429420262
Pubmed

GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.

GBF1 CYTH3 ARF6

2.07e-07764318084281
Pubmed

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

VPS13C SMARCA2 SMARCA4 HNRNPU

1.22e-064364426030138
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

MICALL1 MYO18A SRP54 SRPK2 AKAP13 TANC1 HMMR RBM28 CDC5L PLCH1 PARD3 YME1L1 MXRA7

2.60e-061487641333957083
Pubmed

The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.

SMARCA2 SMARCA4

3.33e-0626428670841
Pubmed

Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.

SMARCA2 SMARCA4

3.33e-06264223163725
Pubmed

Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development.

SMARCA2 SMARCA4

3.33e-06264223076393
Pubmed

Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein.

SMARCA2 SMARCA4

3.33e-0626429603422
Pubmed

The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.

SMARCA2 SMARCA4

3.33e-06264215576411
Pubmed

SWI/SNF gene variants and glioma risk and outcome.

SMARCA2 SMARCA4

3.33e-06264223276717
Pubmed

Differential Expression of SWI/SNF Chromatin Remodeler Subunits Brahma and Brahma-Related Gene During Drug-Induced Liver Injury and Regeneration in Mouse Model.

SMARCA2 SMARCA4

3.33e-06264227097303
Pubmed

Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.

SMARCA2 SMARCA4

3.33e-06264215240517
Pubmed

Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type.

SMARCA2 SMARCA4

3.33e-06264226564006
Pubmed

Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors.

CYTH3 ARF6

3.33e-06264229276036
Pubmed

SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.

SMARCA2 SMARCA4

3.33e-06264233027072
Pubmed

SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.

SMARCA2 SMARCA4

3.33e-06264228038711
Pubmed

A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.

SMARCA2 SMARCA4

3.33e-06264223872584
Pubmed

HDAC6 regulates aggresome-autophagy degradation pathway of α-synuclein in response to MPP+-induced stress.

HDAC6 SNCA

3.33e-06264221235576
Pubmed

Proinflammatory stimuli engage Brahma related gene 1 and Brahma in endothelial injury.

SMARCA2 SMARCA4

3.33e-06264223963727
Pubmed

SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level.

SMARCA2 SMARCA4

3.33e-06264212493776
Pubmed

Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.

SMARCA2 SMARCA4

3.33e-06264231375262
Pubmed

Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma.

SMARCA2 SMARCA4

3.33e-06264223088494
Pubmed

Promiscuity of the catalytic Sec7 domain within the guanine nucleotide exchange factor GBF1 in ARF activation, Golgi homeostasis, and effector recruitment.

GBF1 CYTH1

3.33e-06264230943106
Pubmed

Genome-wide association study confirms extant PD risk loci among the Dutch.

BST1 SNCA

3.33e-06264221248740
Pubmed

Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers.

SMARCA2 SMARCA4

3.33e-06264217075831
Pubmed

Shigella flexneri regulation of ARF6 activation during bacterial entry via an IpgD-mediated positive feedback loop.

CYTH2 ARF6

3.33e-06264225736891
Pubmed

SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.

SMARCA2 SMARCA4

3.33e-06264220333683
Pubmed

SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies.

SMARCA2 SMARCA4

3.33e-06264234812766
Pubmed

Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.

SMARCA2 SMARCA4

3.33e-06264232855269
Pubmed

Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy.

SMARCA2 SMARCA4

3.33e-06264230478150
Pubmed

Signaling through Arf6 guanine-nucleotide exchange factor cytohesin-1 regulates migration in Schwann cells.

CYTH1 ARF6

3.33e-06264223517829
Pubmed

Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.

SMARCA2 SMARCA4

3.33e-06264222721696
Pubmed

Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.

SMARCA2 SMARCA4

3.33e-06264218508913
Pubmed

Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.

SMARCA2 SMARCA4

3.33e-06264211719516
Pubmed

Cytohesin-2 mediates group I metabotropic glutamate receptor-dependent mechanical allodynia through the activation of ADP ribosylation factor 6 in the spinal cord.

CYTH2 ARF6

3.33e-06264234390832
Pubmed

Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion.

CYTH1 ARF6

3.33e-06264220018626
Pubmed

Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor.

CYTH2 CYTH1

3.33e-0626429050849
Pubmed

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.

SMARCA2 SMARCA4

3.33e-06264225808524
Pubmed

Analysis of genome-wide association study-linked loci in Parkinson's disease of Mainland China.

BST1 SNCA

3.33e-06264223853107
Pubmed

Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation.

SMARCA2 SMARCA4

3.33e-06264219144648
Pubmed

ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells.

CYTH2 ARF6

3.33e-06264216484220
Pubmed

FABP2 is Involved in Intestinal α-Synuclein Pathologies.

SNCA FABP2

3.33e-06264238419457
Pubmed

DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.

SMARCA2 SMARCA4

3.33e-06264228706277
Pubmed

[Expression of BRG1 and BRM proteins in prostatic cancer].

SMARCA2 SMARCA4

3.33e-06264221092585
Pubmed

High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.

SMARCA2 SMARCA4

3.33e-06264229391527
Pubmed

Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.

CYTH3 CYTH2

3.33e-06264231601460
Pubmed

Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model.

SMARCA2 SMARCA4

3.33e-06264237634210
Pubmed

SWI/SNF Complex-deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract: A Series of 13 Cases Highlighting Mutually Exclusive Loss of SMARCA4 and SMARCA2 and Frequent Co-inactivation of SMARCB1 and SMARCA2.

SMARCA2 SMARCA4

3.33e-06264226551623
Pubmed

SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.

SMARCA2 SMARCA4

3.33e-06264219458193
Pubmed

Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.

SMARCA2 SMARCA4

3.33e-0626428208605
Pubmed

The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.

SMARCA2 SMARCA4

3.33e-06264234289068
Pubmed

SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.

SMARCA2 SMARCA4

3.33e-06264234518526
Pubmed

SMARCA family of genes.

SMARCA2 SMARCA4

3.33e-06264232312722
Pubmed

Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes.

CYBB HDAC6

3.33e-06264228499252
Pubmed

Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.

SMARCA2 SMARCA4

3.33e-06264226356327
Pubmed

Phospho-HDAC6 Gathers Into Protein Aggregates in Parkinson's Disease and Atypical Parkinsonisms.

HDAC6 SNCA

3.33e-06264232655357
Pubmed

Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.

SMARCA2 SMARCA4

3.33e-06264212566296
Pubmed

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.

SMARCA2 SMARCA4

3.33e-06264211163203
Pubmed

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes.

SMARCA2 SMARCA4

3.33e-06264212620226
Pubmed

RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway.

RRAGA RRAGB

3.33e-0626429394008
Pubmed

SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.

SMARCA2 SMARCA4

3.33e-06264231406271
Pubmed

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.

SMARCA2 SMARCA4

3.33e-06264227039070
Pubmed

Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage.

SMARCA2 SMARCA4

3.33e-06264229848589
Pubmed

Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits.

SMARCA2 SMARCA4

3.33e-06264229273066
Pubmed

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases.

RRAGA RRAGB

3.33e-0626427499430
Pubmed

Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2.

CYTH2 ARF6

3.33e-06264225450674
Pubmed

Histone deacetylase 6 regulates cytotoxic α-synuclein accumulation through induction of the heat shock response.

HDAC6 SNCA

3.33e-06264224866403
Pubmed

A catalogue of putative HIV-1 protease host cell substrates.

SWAP70 SMARCA2 RBM28 CDC5L HNRNPU

3.42e-0612464522944692
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

ACLY SMARCA4 CCAR1 CDC5L RFC1 PLCH1

4.71e-0623464636243803
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

GBF1 HDAC6 SWAP70 MYO18A SMARCA2 CCAR1 SRP54 HMMR RFC1 AARSD1 MXRA7 HNRNPU

6.41e-061367641232687490
Pubmed

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.

POLR1A SMARCA2 SMARCA4 CCAR1 CDC5L RFC1

6.87e-0625064633536335
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

POLR1A VPS13C SMARCA4 AKAP13 TANC1 RBM28 CDC5L PLCH1 MXRA7

7.65e-0673364934672954
Pubmed

Inflammatory Bowel Disease Susceptibility Gene C1ORF106 Regulates Intestinal Epithelial Permeability.

CYTH2 CYTH1

9.99e-06364231022698
Pubmed

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.

SMARCA2 SMARCA4

9.99e-06364228292935
Pubmed

Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.

SMARCA2 SMARCA4

9.99e-06364236464671
Pubmed

SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription.

SMARCA4 HNRNPU

9.99e-06364222162999
Pubmed

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.

SMARCA2 SMARCA4

9.99e-06364230287812
Pubmed

Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6.

CYTH2 ARF6

9.99e-06364220525696
Pubmed

Metabolism. Differential regulation of mTORC1 by leucine and glutamine.

RRAGA RRAGB

9.99e-06364225567907
Pubmed

Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.

MYO18A TANC1

9.99e-06364238092135
Pubmed

Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6.

CYTH2 ARF6

9.99e-06364224581425
Pubmed

ARF6 activation by Galpha q signaling: Galpha q forms molecular complexes with ARNO and ARF6.

CYTH2 ARF6

9.99e-06364216650966
Pubmed

Arf6 guanine-nucleotide exchange factor, cytohesin-2, interacts with actinin-1 to regulate neurite extension.

CYTH2 ARF6

9.99e-06364222659138
Pubmed

Role of curcumin in PLD activation by Arf6-cytohesin1 signaling axis in U46619-stimulated pulmonary artery smooth muscle cells.

CYTH1 ARF6

9.99e-06364228780751
InteractionACTB interactions

CYBB NRAP HDAC6 SWAP70 RRAGA ACLY MYO18A SMARCA2 SMARCA4 LMOD1 SRPK2 TANC1 HMMR CDC5L SNCA HNRNPU

1.45e-0710836316int:ACTB
InteractionGNAQ interactions

HDAC6 CYTH3 CYTH2 CYTH1 AKAP13 ATP4A ARF6

2.10e-07135637int:GNAQ
InteractionHSP90B1 interactions

HDAC6 POLR1A SWAP70 DNAH10 ACLY VPS13C DNAH17 SMARCA4 AKAP13 CDC5L PLCH1 HNRNPU

6.78e-076506312int:HSP90B1
InteractionMYBBP1A interactions

HDAC6 POLR1A SMARCA2 SMARCA4 SRPK2 MACROH2A2 RBM28 CDC5L SNCA HNRNPU

1.60e-064636310int:MYBBP1A
InteractionIPCEF1 interactions

CYTH3 CYTH2 CYTH1

4.72e-0611633int:IPCEF1
InteractionSEPTIN7 interactions

GBF1 HDAC6 CDC5L SNCA PARD3 HNRNPU ARF6

6.99e-06228637int:SEPTIN7
InteractionHECTD1 interactions

POLR1A GPATCH1 MYO18A SMARCA4 SRPK2 MACROH2A2 HMMR RBM28 CDC5L RFC1 YME1L1 AARSD1 HNRNPU

8.92e-069846313int:HECTD1
InteractionCTNND1 interactions

GBF1 HDAC6 CDC5L SNCA PARD3 ATP4A ARF6

1.85e-05265637int:CTNND1
InteractionCYTIP interactions

CYTH3 CYTH2 CYTH1

1.92e-0517633int:CYTIP
InteractionCYTH1 interactions

CYTH3 CYTH2 CYTH1 ARF6

2.62e-0555634int:CYTH1
InteractionSNRPB interactions

HDAC6 ACLY GPATCH1 ANKAR CCAR1 SRPK2 CDC5L SNCA HNRNPU

3.10e-05517639int:SNRPB
InteractionSEPTIN11 interactions

CFLAR GBF1 SMARCA2 SNCA ARF6

3.97e-05122635int:SEPTIN11
InteractionSNIP1 interactions

GPATCH1 SMARCA2 SMARCA4 SRPK2 MACROH2A2 RBM28 CDC5L HNRNPU

4.50e-05417638int:SNIP1
InteractionTOP1 interactions

HDAC6 SMARCA4 CCAR1 SRPK2 MACROH2A2 RBM28 CDC5L RFC1 SNCA HNRNPU

5.53e-056966310int:TOP1
InteractionARHGAP21 interactions

MYO18A AKAP13 SNCA PARD3 HNRNPU ARF6

6.89e-05223636int:ARHGAP21
InteractionLYN interactions

MICALL1 HDAC6 POLR1A CCAR1 TANC1 RBM28 SNCA PLCH1 PARD3 ARF6

7.34e-057206310int:LYN
InteractionARRB2 interactions

POLR1A CYTH2 CYTH1 SRPK2 SYT2 AARSD1 HNRNPU ARF6

8.16e-05454638int:ARRB2
InteractionCTNNA1 interactions

ACLY CDC5L SNCA PLCH1 PARD3 STX17 CTSV

1.02e-04347637int:CTNNA1
InteractionYWHAE interactions

MICALL1 GBF1 NRAP HDAC6 ACLY CYTH2 AKAP13 TANC1 CDC5L SNCA PLCH1 PARD3 HNRNPU

1.13e-0412566313int:YWHAE
InteractionEED interactions

TBC1D9B ACLY VPS13C MYO18A SMARCA2 SMARCA4 CCAR1 SRPK2 MACROH2A2 TANC1 RBM28 CDC5L HNRNPU ARF6

1.19e-0414456314int:EED
InteractionKHDRBS1 interactions

HDAC6 ACLY SMARCA2 SRP54 SRPK2 HMMR CDC5L

1.60e-04373637int:KHDRBS1
InteractionSH3GL1 interactions

MICALL1 GBF1 STX17 AARSD1 HNRNPU

1.61e-04164635int:SH3GL1
InteractionCCDC40 interactions

CYTH2 CYTH1 HMMR

1.63e-0434633int:CCDC40
InteractionCALD1 interactions

GBF1 HDAC6 ACLY MYO18A LMOD1 SNCA

1.77e-04265636int:CALD1
InteractionEPS8L3 interactions

HDAC6 SRPK2

2.00e-047632int:EPS8L3
InteractionKPNA2 interactions

GBF1 POLR1A ACLY SMARCA2 SMARCA4 CDC5L SNCA HNRNPU

2.05e-04519638int:KPNA2
InteractionTOP2A interactions

SMARCA4 SRP54 SRPK2 MACROH2A2 CDC5L RFC1 SNCA HNRNPU

2.07e-04520638int:TOP2A
InteractionRB1 interactions

SMARCA2 SMARCA4 CCAR1 RFC1 STX17 CTSV HNRNPU

2.23e-04394637int:RB1
InteractionTRAF3 interactions

CFLAR SWAP70 ACLY SMARCA4 HNRNPU OTUD7B

2.29e-04278636int:TRAF3
InteractionLMO7 interactions

HDAC6 MYO18A SRPK2 CDC5L PARD3

2.30e-04177635int:LMO7
InteractionCDH13 interactions

HDAC6 RRAGB HMMR

2.65e-0440633int:CDH13
InteractionRBM14-RBM4 interactions

GBF1 DNAH17 C3orf49 AARSD1

2.72e-04100634int:RBM14-RBM4
InteractionNPM1 interactions

HDAC6 SWAP70 SMARCA4 SRP54 LMOD1 CCDC80 SRPK2 MACROH2A2 RBM28 RFC1 SNCA HNRNPU

2.99e-0412016312int:NPM1
InteractionDBNL interactions

GBF1 POLR1A ACLY SNCA PLCH1

3.19e-04190635int:DBNL
InteractionBICRAL interactions

SMARCA2 SMARCA4 CDC5L

3.29e-0443633int:BICRAL
InteractionFBXW7 interactions

CYBB POLR1A ACLY MYO18A SMARCA4 SRPK2 AKAP13 MACROH2A2 RBM28 RFC1 SNCA YME1L1

3.33e-0412156312int:FBXW7
InteractionEPB41L2 interactions

GBF1 HDAC6 ACLY SMARCA4 SRPK2 ARF6

3.39e-04299636int:EPB41L2
InteractionFRMD4B interactions

CYTH3 CYTH1

3.41e-049632int:FRMD4B
InteractionNAT10 interactions

HDAC6 SRPK2 RBM28 CDC5L SNCA HNRNPU

3.57e-04302636int:NAT10
InteractionCUL1 interactions

CFLAR HDAC6 POLR1A SWAP70 SMARCA4 CCDC168 RBM28 CDC5L RFC1 HNRNPU

3.61e-048766310int:CUL1
InteractionARRB1 interactions

POLR1A CYTH2 CYTH1 SNCA HNRNPU ARF6

3.70e-04304636int:ARRB1
InteractionCDC42BPB interactions

HDAC6 MYO18A MACROH2A2 SNCA

3.77e-04109634int:CDC42BPB
InteractionLAMTOR1 interactions

MICALL1 HDAC6 RRAGA VPS13C RRAGB RBM28 PLCH1 PARD3 ARF6

3.87e-04722639int:LAMTOR1
InteractionRAB35 interactions

MICALL1 HDAC6 VPS13C TANC1 PLCH1 PARD3 MXRA7 ARF6

3.98e-04573638int:RAB35
InteractionLAMTOR4 interactions

RRAGA RRAGB SNCA

4.02e-0446633int:LAMTOR4
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

SWAP70 CYTH3 CYTH2 CYTH1 AKAP13

1.54e-04206455682
GeneFamilyAAA ATPases

SPG7 RFC1 YME1L1

3.09e-0453453413
GeneFamilyDyneins, axonemal

DNAH10 DNAH17

8.04e-0417452536
CoexpressionGSE41867_NAIVE_VS_DAY6_LCMV_EFFECTOR_CD8_TCELL_DN

CYBB SPG7 SWAP70 CYTH1 MYO18A AKAP13 STX17

5.22e-07200637M9463
ToppCellControl-Multiplet|Control / Disease state, Lineage and Cell class

AFF3 CCDC80 CATSPERB TANC1 PLCH1 PARD3

3.73e-07195646618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCellControl-Multiplet-Multiplet|Control / Disease state, Lineage and Cell class

AFF3 CCDC80 CATSPERB TANC1 PLCH1 PARD3

3.73e-0719564606ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal|GW19 / Sample Type, Dataset, Time_group, and Cell type.

OLFM3 TMC1 DNAH17 TANC1 ARF6

3.33e-06159645f34f2729a3872fbb2939e76ad35d7e25f71b8f57
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Mesenchymal-Unfolded_protein_responsible_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

OLFM3 TMC1 DNAH17 TANC1 ARF6

3.33e-06159645929ed98f6c2ad14e8d5af5c6f11a5a3d4b388cf7
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CYTH3 SMARCA2 SMARCA4 MXRA7 HNRNPU

7.94e-06190645d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 CCDC80 TANC1 ABCA10

9.46e-06197645ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 CCDC80 TANC1 ABCA10

9.46e-0619764537f6b6f2809b952382eaebb642b0aad6371f4251
ToppCell3'_v3-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

HOXA3 AFF3 CCDC168 SYT2

6.29e-05149644d7f1069f70f3cad6d3700ee2041ed1d4cb7c49ab
ToppCellSevere-B_naive-11|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CYBB VPS13C ANKAR AFF3

8.49e-05161644ad3b58e3a8b59a609c8d2d2690d15218d18eabbd
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NRAP SYT2 PLCH1 FABP2

9.78e-05167644d78356bf0c473816dbabaee51984940bd822f84e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 CCDC80 TANC1

1.05e-04170644fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 CCDC80 TANC1

1.05e-0417064403044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HOXA3 AACS CCDC80 AARSD1

1.05e-04170644b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCellSevere-B_naive-11|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CYBB VPS13C ANKAR AFF3

1.07e-041716447c2699f19ca38414447a286f7658f507882d57c2
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BST1 SMARCA4 MACROH2A2 PLCH1

1.15e-041746440fccd90ef72ec2e5eb369fe6d6d126c60886485a
ToppCellPND07-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFLAR TMC1 SNCA OTUD7B

1.15e-04174644a3f4981b10afa9d41a1c66c7f98522a8a534f82b
ToppCellPND07-Immune-Immune_Myeloid-Megakaryocyte/Platelet|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFLAR TMC1 SNCA OTUD7B

1.15e-041746446cc108dde4b3f98a78a6040280f0d5e4aaa5bd75
ToppCellPND07-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CFLAR TMC1 SNCA OTUD7B

1.15e-041746444b8bc5568e36031c8ecf001bb646809038c23919
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 CCDC80 ABCA10

1.17e-04175644795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-11|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SWAP70 ANKAR TTC12 AFF3

1.22e-041776443535575686c9700ab72700aae6f2070ebbb50044
ToppCelldroplet-Spleen-nan-18m-Lymphocytic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SWAP70 CYTH1 SRP54 HNRNPU

1.39e-0418364428cbf909424f3be4491d49832f0aca0386560814
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SWAP70 CYTH1 SRP54 HNRNPU

1.39e-041836443fa608aa6b119869ec3280dc388dfee57160e63a
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AFF3 MACROH2A2 TANC1 STX17

1.42e-04184644a6dee97ee4ef9d89e11d17339e0dadaea1210ce5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 CCDC80 ABCA10

1.42e-04184644e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

TBC1D9B GBF1 DNAH10 MXRA7

1.42e-04184644ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BST1 VPS13C DNAH17 HMMR

1.42e-04184644e7b9c69fc77040c5191ad8089697051e2589c30e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 TANC1 ABCA10

1.57e-0418964471397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 TANC1 ABCA10

1.57e-041896444eea4759520c312bd17a681034d8074e47093d2b
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CYBB SWAP70 VPS13C AFF3

1.57e-04189644e2bb5900d210386b7b74938e7a3636d0c7ba1bcf
ToppCell10x3'2.3-week_17-19-Lymphocytic_B-B_lineage-naive_B_cell|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SWAP70 VPS13C AFF3 AKAP13

1.64e-04191644a073d58154c801ec499fd969f42b7f1ee7f15d79
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-Cycling_Dendritic|bone_marrow / Manually curated celltypes from each tissue

AFF3 HMMR SNCA CTSV

1.64e-04191644aa9c0b1b90cdb7a95d4e6332819f82cae0a79ff9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 TANC1 ABCA10

1.64e-0419164439092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCellMild/Remission-B_naive-11|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CYBB SWAP70 VPS13C AFF3

1.64e-04191644ebb165096de301ba663703d1662d9413ea317867
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 TANC1 ABCA10

1.64e-04191644ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCellControl-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

AFF3 CATSPERB TANC1 PARD3

1.67e-041926441bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBF1 HDAC6 ACLY PARD3

1.67e-041926445b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 CCDC80 ABCA10

1.67e-041926445105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRAP TTC12 LMOD1 MXRA7

1.67e-04192644be75783d9578974b662e1cb13bd3442a921fd50a
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

AFF3 TANC1 PLCH1 PARD3

1.67e-04192644efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellMild/Remission-B_naive-11|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

CYBB SWAP70 VPS13C AFF3

1.67e-04192644c6f325cddce43b72f013b21dfffc9987fd68b6a7
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRAP TTC12 LMOD1 MXRA7

1.67e-041926444fc98f30f8e738816cd93101fbe8ac40889e302a
ToppCellLA|World / Chamber and Cluster_Paper

AFF3 LMOD1 CCDC80 ABCA10

1.71e-04193644d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 TANC1 ABCA10

1.74e-0419464481713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic-B_cell|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CYBB SWAP70 VPS13C AFF3

1.74e-04194644ff661419b697aef51a53fdeac8d37d870d65f491
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 CCDC80 ABCA10

1.74e-04194644e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

AFF3 CATSPERB PLCH1 PARD3

1.74e-0419464497534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 TANC1 ABCA10

1.74e-04194644627cffe2d448e74fc5df92e74e5b922a73304137
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

DNAH10 TANC1 PLCH1 PARD3

1.77e-04195644fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 LMOD1 CCDC80 ABCA10

1.77e-041956443c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

DNAH10 TANC1 PLCH1 PARD3

1.77e-04195644eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

CCDC80 TANC1 PLCH1 PARD3

1.81e-04196644af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

CCDC80 TANC1 PLCH1 PARD3

1.81e-041966446d02d494196e3f857d53eea46d9419690d43beca
ToppCellCOVID-19_Convalescent-Classical_Monocyte-cMono_2|COVID-19_Convalescent / Disease condition and Cell class

CYBB BST1 HNRNPU ARF6

1.88e-04198644f65fd9b773aeafa55e38309479954a8e41371f52
ToppCell3'-GW_trimst-2-SmallIntestine|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HOXA3 OLFM3 BTNL3 FABP2

1.88e-04198644cc162ba4b3b8dec667a8cffd3411965f3f856f8c
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

VPS13C SMARCA2 SRP54 SRPK2

1.92e-0419964461b1ed2db71b96157b92b7535d1955a4033098da
ToppCell(4)_Endothelial_cells-(4)_Blood_vessel|(4)_Endothelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

CFLAR SWAP70 CYTH1 AKAP13

1.92e-04199644e24d70e79f25cdd3300bf5e2322713355264d4c5
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

DNAH17 SMARCA2 PLCH1 PARD3

1.95e-04200644f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCellTransverse-Dendritic_cell-cycling_DCs|Dendritic_cell / Region, Cell class and subclass

CYBB BST1 HMMR SNCA

1.95e-04200644617a6a42f7b31eb3c45bdceaf55a591b6de7f154
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

DNAH17 SMARCA2 PLCH1 PARD3

1.95e-0420064470a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

VPS13C CYTH1 AKAP13 HNRNPU

1.95e-0420064412f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1|Neuronal / cells hierarchy compared to all cells using T-Statistic

DNAH17 SMARCA2 PLCH1 PARD3

1.95e-042006441639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCellCOVID-19|World / Disease, condition lineage and cell class

VPS13C AKAP13 YME1L1 HNRNPU

1.95e-042006447dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellSigmoid-(1)_T_cell-(18)_cycling_gd_T|Sigmoid / shred on region, Cell_type, and subtype

GBF1 MYO18A HMMR RBM28

1.95e-042006446e367abd1a4b87e20eb9095b8337723163e8bbae
ToppCellSigmoid-T_cell-cycling_gd_T|Sigmoid / Region, Cell class and subclass

GBF1 MYO18A HMMR RBM28

1.95e-042006449769185abae084ffac36420c749625e679b70ca8
DrugEstriol [50-27-1]; Down 200; 13.8uM; MCF7; HT_HG-U133A

CFLAR TBC1D9B CYTH1 SMARCA2 SMARCA4 AKAP13 MACROH2A2

1.09e-061916477220_DN
DrugSecinH3

CYTH3 CYTH2 CYTH1

1.76e-069643CID001029232
Drugglycylglycylglycine

CYTH3 CYTH2 CYTH1 ARF6

4.81e-0640644CID000011161
Drugguanine

GBF1 SWAP70 BST1 RRAGA CYTH3 CYTH2 CYTH1 SRP54 AKAP13 RRAGB PLCH1 ARF6

6.83e-069026412CID000000764
DrugMethylergometrine maleate [113-42-8]; Up 200; 8.8uM; HL60; HG-U133A

CFLAR SWAP70 BST1 CYTH1 DNAH17 AKAP13

7.50e-061676461607_UP
DrugButoconazole nitrate [32872-77-1]; Up 200; 8.4uM; MCF7; HT_HG-U133A

CFLAR HDAC6 SWAP70 CYTH1 AFF3 PLCH1

1.76e-051946463288_UP
DrugTocainide hydrochloride; Up 200; 17.4uM; MCF7; HT_HG-U133A

MICALL1 ACLY SMARCA2 SMARCA4 RRAGB PARD3

1.76e-051946464838_UP
DrugTranexamic acid [1197-18-8]; Up 200; 25.4uM; PC3; HT_HG-U133A

CFLAR CYTH1 TTC12 AKAP13 SNCA PLCH1

1.81e-051956462085_UP
DrugCiprofibrate [52214-84-3]; Down 200; 13.8uM; MCF7; HT_HG-U133A

HDAC6 TTC12 SMARCA2 SMARCA4 AARSD1 ARF6

1.92e-051976463561_DN
DrugNaloxone hydrochloride [357-08-4]; Up 200; 11uM; PC3; HG-U133A

MICALL1 CFLAR GBF1 SMARCA4 SRPK2 MACROH2A2

1.98e-051986461924_UP
Drugalpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A

MICALL1 CFLAR HDAC6 AKAP13 RRAGB CDC5L

2.03e-051996465207_DN
DrugAC1N9TEG

HDAC6 CYTH3 CYTH2 CYTH1 ARF6

2.61e-05124645CID000000478
DiseaseMENTAL RETARDATION, AUTOSOMAL DOMINANT 12

SMARCA2 SMARCA4

4.61e-055642C3281201
Diseasealcohol use disorder (implicated_via_orthology)

SMARCA2 SMARCA4 CDC5L CTSV ARF6

6.65e-05195645DOID:1574 (implicated_via_orthology)
Diseasestromal cell-derived factor 1 alpha measurement

SPG7 TTC12 SNCA

1.13e-0443643EFO_0008293
Diseaseopportunistic bacterial infectious disease (implicated_via_orthology)

SMARCA2 SMARCA4

1.65e-049642DOID:0050340 (implicated_via_orthology)
DiseaseCoffin-Siris syndrome

SMARCA2 SMARCA4

3.56e-0413642C0265338
Diseaseshigellosis

CYTH3 YME1L1

5.45e-0416642EFO_0005585
Diseasecentral corneal thickness

AFF3 CCDC80 AKAP13 ABCA10 MXRA7

5.61e-04309645EFO_0005213
DiseaseSensorineural Hearing Loss (disorder)

TMC1 YME1L1

1.14e-0323642C0018784
Diseasenighttime rest measurement

MYO18A TANC1

1.24e-0324642EFO_0007827
Diseasepulmonary embolism

DNAH17 FABP2

1.35e-0325642EFO_0003827
Diseasecerebellum cortex volume change measurement, age at assessment

TMC1 PLCH1

1.46e-0326642EFO_0008007, EFO_0021497
Diseasebiological sex

AFF3 SMARCA2 SRPK2 PARD3

1.58e-03230644PATO_0000047
Diseasetreatment-resistant hypertension

OLFM3 POLR1A AACS

1.73e-03109643EFO_1002006

Protein segments in the cluster

PeptideGeneStartEntry
GKMPNKMIRKGVFKD

PRPF4B

906

Q13523
RMKHKADAMVEKFGK

AFF3

986

P51826
GSMKVLEKRLKDMGF

BST1

241

Q10588
VMGMIIVFFKSKGKI

BTNL3

251

Q6UXE8
AKMEKKMKILLGGYQ

CDC5L

711

Q99459
RNMFHMSKKTGKFKQ

CATSPERB

896

Q9H7T0
ARERGKFKKLMTVMG

ABCA10

156

Q8WWZ4
FAAAMRKMGVKKGDR

AACS

141

Q86V21
MMGCFRNQKFRKGKV

CTSV

91

O60911
KFLVGMKGKDEAMAI

CCAR1

486

Q8IX12
DKFMEKMGVNIVKRK

FABP2

16

P12104
MSGRSGKKKMSKLSR

MACROH2A2

1

Q9P0M6
MKSGQMFAKEDLKRK

AKAP13

2216

Q12802
KGRFQGKATKMSRRM

AARSD1

381

Q9BTE6
MKDYMGRGKISKEKS

CFLAR

116

O15519
KLMSFLKLEKGKFGM

CCDC80

221

Q76M96
EAGKALKGMNMKEIK

RBM28

166

Q9NW13
FKGKQISVQMKGAMA

ANKAR

916

Q7Z5J8
KTLGSKLKKNMGGLM

OTUD7B

511

Q6GQQ9
KLKKNMGGLMHSKGS

OTUD7B

516

Q6GQQ9
NRRMKYKKDQKGKGM

HOXA3

241

O43365
KEAFEKMKGQMLGSR

NRAP

1066

Q86VF7
VGDKQSAVKMKMFGK

GPATCH1

591

Q9BRR8
GEKMKRAGGNTDMKK

LMOD1

236

P29536
MFNLMKKDKDKDGGR

MYO18A

1

Q92614
TTRVGMKLKEKKMAF

CES4A

531

Q5XG92
KMMVAGFKKQMADTG

HNRNPU

536

Q00839
VAMGRKKFNMDPKKG

CYTH1

66

Q15438
KGKFKTMKMLKLLGN

MICALL1

836

Q8N3F8
KRETKMRGMMAKQEG

HMMR

176

O75330
MRKYKLKNMTTKGPG

C3orf49

276

Q96BT1
KNEMFVMSGKIKGKT

DNAH17

146

Q9UFH2
AMGRKKFNMDPKKGI

CYTH2

66

Q99418
AMGRKKFNMDPKKGI

CYTH3

71

O43739
QMKKKGFKMEVGQYI

CYBB

311

P04839
YVGTNMKKLKMRAGG

GBF1

206

Q92538
QEGKMQEGKGKSSMK

CCDC168

3706

Q8NDH2
KKKGKMKKLGQAMEE

HDAC6

51

Q9UBN7
QKGEKQAMKNYGRKM

DNAH10

1701

Q8IVF4
DMAAKMSKKKKAGGG

ATP4A

21

P20648
KMETQMKGLKAKFRQ

OLFM3

116

Q96PB7
KAKKGMLKGLGDMFR

PARD3

1011

Q8TEW0
KEKGKGMKNAMNMKD

SYT2

96

Q8N9I0
MDVFMKGLSKAKEGV

SNCA

1

P37840
LEKKEGLFRKHMMGK

POLR1A

421

O95602
KFAQMVKKMGGIKGL

SRP54

426

P61011
KKGKGGAKTLMNTIM

SMARCA2

996

P51531
KGAMMSIAFKEGLKI

RFC1

781

P35251
KKGKGGTKTLMNTIM

SMARCA4

1026

P51532
GNVMYKKGKMKEAAQ

TANC1

1296

Q9C0D5
KMARFTIVDGKMGKG

SPG7

291

Q9UQ90
LRNKDVKDSMKKMFG

OR5T2

331

Q8NGG2
KFKEAELKMRKQFGM

TBC1D9B

136

Q66K14
KGKGKRWFAFKMMMA

TMC1

136

Q8TDI8
NKMKKEGKLIMGIGH

ACLY

961

P53396
MGKVLSKIFGNKEMR

ARF6

1

P62330
GGKLIQRKKQKMMEK

STX17

271

P56962
MKKKVLLMGKSGSGK

RRAGA

6

Q7L523
MQGKRFVAMKVVKSA

SRPK2

101

P78362
GKMFKDGSMNVSVKL

VPS13C

1981

Q709C8
NTAMKKKVLLMGKSG

RRAGB

36

Q5VZM2
AKGRKKSKMGFQEMV

PLCH1

926

Q4KWH8
KRMVTKFGMSEKLGV

YME1L1

686

Q96TA2
AGVVKKMMKFLKTGG

TTC12

561

Q9H892
VLKQGYMMKKGHRRK

SWAP70

211

Q9UH65
GKLRGNQYKKMMTKE

MXRA7

146

P84157