Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	steroid 11-beta-monooxygenase activity	CYP11B1 CYP11B2	2.43e-05	2	99	2	GO:0004507
GeneOntologyMolecularFunction	corticosterone 18-monooxygenase activity	CYP11B1 CYP11B2	2.43e-05	2	99	2	GO:0047783
GeneOntologyMolecularFunction	ankyrin binding	SLC4A1 SPTBN4 SCN5A	1.95e-04	23	99	3	GO:0030506
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP8B1 CYP11B1 CYP11B2 KDM5C KDM4E FADS2	4.12e-04	194	99	6	GO:0016705
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP8B1 CYP11B1 CYP11B2	6.33e-04	34	99	3	GO:0008395
GeneOntologyBiologicalProcess	regulation of blood volume by renal aldosterone	CYP11B1 CYP11B2 HSD11B2	4.28e-07	4	99	3	GO:0002017
GeneOntologyBiologicalProcess	positive regulation of systemic arterial blood pressure	AVPR2 CYP11B1 CYP11B2 HSD11B2	9.36e-06	28	99	4	GO:0003084
GeneOntologyBiologicalProcess	circulatory system process	C2CD4B AVPR2 CYP11B1 CYP11B2 KCNE5 C2CD4A PPP1R13L TGFB1 SPTBN4 UCN SLC22A3 SCN5A SERPING1 HSD11B2	1.05e-05	733	99	14	GO:0003013
GeneOntologyBiologicalProcess	blood circulation	C2CD4B AVPR2 CYP11B1 CYP11B2 KCNE5 C2CD4A PPP1R13L TGFB1 SPTBN4 UCN SCN5A SERPING1 HSD11B2	1.33e-05	648	99	13	GO:0008015
GeneOntologyBiologicalProcess	cortisol metabolic process	CYP11B1 CYP11B2 HSD11B2	2.29e-05	12	99	3	GO:0034650
GeneOntologyBiologicalProcess	renal system process	AVPR2 CYP11B1 CYP11B2 SLC4A1 PKN1 HSD11B2	8.28e-05	149	99	6	GO:0003014
GeneOntologyBiologicalProcess	drinking behavior	CYP11B1 CYP11B2 UCN	8.31e-05	18	99	3	GO:0042756
GeneOntologyBiologicalProcess	renal system process involved in regulation of blood volume	CYP11B1 CYP11B2 HSD11B2	8.31e-05	18	99	3	GO:0001977
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by hormone	AVPR2 CYP11B1 CYP11B2 HSD11B2	1.05e-04	51	99	4	GO:0001990
GeneOntologyBiologicalProcess	regulation of vascular permeability involved in acute inflammatory response	C2CD4B C2CD4A	1.36e-04	4	99	2	GO:0002528
GeneOntologyBiologicalProcess	tertiary alcohol metabolic process	CYP11B1 CYP11B2 HSD11B2	1.55e-04	22	99	3	GO:1902644
GeneOntologyBiologicalProcess	positive regulation of blood pressure	AVPR2 CYP11B1 CYP11B2 HSD11B2	1.86e-04	59	99	4	GO:0045777
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure mediated by a chemical signal	AVPR2 CYP11B1 CYP11B2 HSD11B2	2.11e-04	61	99	4	GO:0003044
HumanPheno	Polydipsia	AVPR2 CYP11B1 CYP11B2 NPHP3 HSD11B2	2.97e-05	53	36	5	HP:0001959
HumanPheno	Poikilocytosis	PIEZO1 KCNE5 XK SLC4A1 CLPB	6.40e-05	62	36	5	HP:0004447
HumanPheno	Decreased circulating renin concentration	AVPR2 CYP11B1 HSD11B2	6.83e-05	12	36	3	HP:0003351
HumanPheno	Abnormality of the renin-aldosterone axis	AVPR2 CYP11B1 HSD11B2	6.83e-05	12	36	3	HP:0003350
HumanPheno	Abnormal circulating renin concentration	AVPR2 CYP11B1 CYP11B2 HSD11B2	7.43e-05	33	36	4	HP:0040084
HumanPheno	Abnormal blood monovalent inorganic cation concentration	AVPR2 CYP11B1 CYP11B2 PIEZO1 SLC4A1 SCN5A HSD11B2	8.04e-05	154	36	7	HP:0010930
HumanPheno	Abnormal blood potassium concentration	CYP11B1 CYP11B2 PIEZO1 SLC4A1 SCN5A HSD11B2	1.18e-04	113	36	6	HP:0011042
HumanPheno	Secretory adrenocortical adenoma	CYP11B1 CYP11B2	1.45e-04	3	36	2	HP:0011746
HumanPheno	Episodic fatigue	PIEZO1 SLC4A1	1.45e-04	3	36	2	HP:0012431
HumanPheno	Hypokalemia	CYP11B1 CYP11B2 SLC4A1 SCN5A HSD11B2	2.04e-04	79	36	5	HP:0002900
HumanPheno	Abnormal drinking behavior	AVPR2 CYP11B1 CYP11B2 NPHP3 HSD11B2	2.30e-04	81	36	5	HP:0030082
HumanPheno	Abnormal urine sodium concentration	AVPR2 CYP11B2 HSD11B2	2.46e-04	18	36	3	HP:0012603
MousePheno	decreased circulating mineralocorticoid level	CYP11B1 CYP11B2 TGFB1 HSD11B2	1.46e-06	14	89	4	MP:0003374
MousePheno	decreased circulating aldosterone level	CYP11B1 CYP11B2 TGFB1 HSD11B2	1.46e-06	14	89	4	MP:0002667
MousePheno	decreased urine osmolality	AVPR2 CYP11B1 CYP11B2 SLC4A1 TGFB1	2.31e-05	54	89	5	MP:0002988
MousePheno	decreased circulating renin level	CYP11B1 CYP11B2 TGFB1	2.90e-05	10	89	3	MP:0003353
MousePheno	abnormal urine progesterone level	CYP11B1 CYP11B2	4.01e-05	2	89	2	MP:0011545
MousePheno	abnormal urine deoxycorticosterone level	CYP11B1 CYP11B2	4.01e-05	2	89	2	MP:0011552
MousePheno	decreased urine corticosterone level	CYP11B1 CYP11B2	4.01e-05	2	89	2	MP:0011550
MousePheno	increased urine deoxycorticosterone level	CYP11B1 CYP11B2	4.01e-05	2	89	2	MP:0011553
MousePheno	increased urine progesterone level	CYP11B1 CYP11B2	4.01e-05	2	89	2	MP:0011546
MousePheno	cardiac fibrosis	NOL3 CYP11B1 CYP11B2 PPP1R13L SLC4A1 RASSF1 SCN5A	4.91e-05	151	89	7	MP:0003141
MousePheno	abnormal urine osmolality	AVPR2 CYP11B1 CYP11B2 SLC4A1 TGFB1	5.71e-05	65	89	5	MP:0002987
MousePheno	abnormal circulating mineralocorticoid level	CYP11B1 CYP11B2 TGFB1 HSD11B2	9.60e-05	38	89	4	MP:0003372
MousePheno	abnormal circulating aldosterone level	CYP11B1 CYP11B2 TGFB1 HSD11B2	9.60e-05	38	89	4	MP:0005346
MousePheno	abnormal aldosterone level	CYP11B1 CYP11B2 TGFB1 HSD11B2	1.30e-04	41	89	4	MP:0011415
MousePheno	abnormal adrenal gland zona glomerulosa morphology	CYP11B1 CYP11B2	2.39e-04	4	89	2	MP:0008293
MousePheno	decreased urine aldosterone level	CYP11B1 CYP11B2	2.39e-04	4	89	2	MP:0011541
MousePheno	abnormal urine aldosterone level	CYP11B1 CYP11B2	2.39e-04	4	89	2	MP:0011539
MousePheno	abnormal urine corticosterone level	CYP11B1 CYP11B2	2.39e-04	4	89	2	MP:0011548
MousePheno	decreased urine hormone level	CYP11B1 CYP11B2	2.39e-04	4	89	2	MP:0014459
MousePheno	polyuria	AVPR2 CYP11B1 CYP11B2 SLC4A1 HSD11B2	2.55e-04	89	89	5	MP:0001762
MousePheno	increased circulating glucocorticoid level	CYP11B1 CYP11B2 TGFB1 UCN	3.05e-04	51	89	4	MP:0003367
MousePheno	increased circulating corticosterone level	CYP11B1 CYP11B2 TGFB1 UCN	3.05e-04	51	89	4	MP:0001745
MousePheno	abnormal urination	AVPR2 CYP11B1 CYP11B2 SLC4A1 TGFB1 HSD11B2	3.59e-04	148	89	6	MP:0001756
MousePheno	decreased circulating potassium level	CYP11B1 CYP11B2 TGFB1 HSD11B2	3.81e-04	54	89	4	MP:0005628
MousePheno	increased adrenal gland zona fasciculata size	CYP11B1 CYP11B2	3.96e-04	5	89	2	MP:0014286
MousePheno	increased circulating renin level	CYP11B1 CYP11B2 TGFB1	4.03e-04	23	89	3	MP:0003352
MousePheno	oliguria	CYP11B1 CYP11B2 TGFB1	4.58e-04	24	89	3	MP:0003620
MousePheno	ventricular tachycardia	KCNE5 PPP1R13L SCN5A	4.58e-04	24	89	3	MP:0008950
MousePheno	ventricular premature beat	KCNE5 PPP1R13L SCN5A	5.18e-04	25	89	3	MP:0009732
MousePheno	abnormal cyst	CYP11B1 CYP11B2 CCDC88B FANCA NPHP3 LRP6 PRKDC PCNT	5.62e-04	294	89	8	MP:0031310
MousePheno	uterus adenomyosis	CYP11B1 CYP11B2	5.91e-04	6	89	2	MP:0009221
MousePheno	increased urine hormone level	CYP11B1 CYP11B2	5.91e-04	6	89	2	MP:0014458
MousePheno	adrenal gland hyperplasia	CYP11B1 CYP11B2	5.91e-04	6	89	2	MP:0009078
MousePheno	abnormal urine homeostasis	ZNF219 AVPR2 CYP11B1 CYP11B2 SLC4A1 TGFB1 PXMP2 PRKDC HSD11B2 HPS5	7.41e-04	466	89	10	MP:0009643
MousePheno	abnormal circulating renin level	CYP11B1 CYP11B2 TGFB1	8.09e-04	29	89	3	MP:0003349
MousePheno	abnormal urine hormone level	CYP11B1 CYP11B2	8.24e-04	7	89	2	MP:0011538
MousePheno	pituitary gland hyperplasia	CYP11B1 CYP11B2	8.24e-04	7	89	2	MP:0000635
MousePheno	dilated distal convoluted tubule	NPHP3 HSD11B2	8.24e-04	7	89	2	MP:0009051
MousePheno	abnormal lymph node size	KATNAL2 NOL3 SLC35C1 PRAMEF19 PRAMEF18 CCDC88B TGFB1 ULK3 STOML1 PRKDC TEDC1	8.43e-04	561	89	11	MP:0000701
MousePheno	abnormal chloride level	AVPR2 CYP11B1 CYP11B2 SLC4A1 TGFB1 HSD11B2	8.44e-04	174	89	6	MP:0012007
Domain	-	PRAMEF19 PIDD1 NLRP1 LRRC4C PRAMEF18 LRRC43 CIITA LINGO4 LRRC28 LRRC23	8.62e-06	321	100	10	3.80.10.10
Domain	L_dom-like	PRAMEF19 PIDD1 NLRP1 LRRC4C PRAMEF18 LRRC43 CIITA LINGO4 LRRC28 LRRC23	1.04e-05	328	100	10	IPR032675
Domain	Cyt_P450_mitochondrial	CYP11B1 CYP11B2	2.84e-05	2	100	2	IPR002399
Domain	LRR	PIDD1 NLRP1 LRRC4C LRRC43 CIITA LINGO4 LRRC23	1.04e-04	201	100	7	PS51450
Domain	Leu-rich_rpt	PIDD1 NLRP1 LRRC4C LRRC43 CIITA LINGO4 LRRC28 LRRC23	1.04e-04	271	100	8	IPR001611
Domain	LRR_1	PIDD1 NLRP1 LRRC4C CIITA LINGO4 LRRC28 LRRC23	1.76e-04	219	100	7	PF00560
Domain	Pentatricopeptide_repeat	DTNB XAB2 PRKDC	2.44e-04	23	100	3	IPR002885
Domain	ARM-type_fold	MYBBP1A CAND2 HSPBP1 PSME4 CEBPZ IFRD2 PRKDC AP4B1	4.74e-04	339	100	8	IPR016024
Domain	AAA+_ATPase	KATNAL2 PSMC3 MCM7 MDN1 CLPB	1.06e-03	144	100	5	IPR003593
Domain	AAA	KATNAL2 PSMC3 MCM7 MDN1 CLPB	1.06e-03	144	100	5	SM00382
Domain	-	CAND2 HSPBP1 PSME4 IFRD2 PRKDC AP4B1	1.24e-03	222	100	6	1.25.10.10
Domain	JmjN	KDM5C KDM4E	1.24e-03	10	100	2	SM00545
Domain	JMJN	KDM5C KDM4E	1.24e-03	10	100	2	PS51183
Domain	MKP	DUSP2 DUSP9	1.24e-03	10	100	2	IPR008343
Domain	JmjN	KDM5C KDM4E	1.24e-03	10	100	2	PF02375
Domain	JmjN	KDM5C KDM4E	1.24e-03	10	100	2	IPR003349
Domain	-	NOL3 PIDD1 NLRP1 MALT1	1.57e-03	93	100	4	1.10.533.10
Domain	DEATH-like_dom	NOL3 PIDD1 NLRP1 MALT1	1.97e-03	99	100	4	IPR011029
Domain	LRR_8	PIDD1 LRRC4C LRRC43 LINGO4 LRRC28	2.27e-03	171	100	5	PF13855
Domain	ATPase_AAA_core	KATNAL2 PSMC3 CLPB	3.03e-03	54	100	3	IPR003959
Domain	LRR_6	NLRP1 CIITA LRRC23	3.19e-03	55	100	3	PF13516
Domain	ARM-like	CAND2 HSPBP1 PSME4 IFRD2 PRKDC AP4B1	3.31e-03	270	100	6	IPR011989
Domain	CYTOCHROME_P450	CYP8B1 CYP11B1 CYP11B2	3.53e-03	57	100	3	PS00086
Domain	-	CYP8B1 CYP11B1 CYP11B2	3.71e-03	58	100	3	1.10.630.10
Domain	p450	CYP8B1 CYP11B1 CYP11B2	3.71e-03	58	100	3	PF00067
Domain	Cyt_P450	CYP8B1 CYP11B1 CYP11B2	4.09e-03	60	100	3	IPR001128
Domain	PRAME_family	PRAMEF19 PRAMEF18	4.57e-03	19	100	2	IPR026271
Domain	RHOD	DUSP2 DUSP9	6.11e-03	22	100	2	SM00450
Domain	HEAT_REPEAT	CAND2 PSME4 PRKDC	6.29e-03	70	100	3	PS50077
Domain	NACHT	NLRP1 CIITA	6.67e-03	23	100	2	PS50837
Domain	NACHT_NTPase	NLRP1 CIITA	6.67e-03	23	100	2	IPR007111
Domain	RHODANESE_3	DUSP2 DUSP9	6.67e-03	23	100	2	PS50206
Pathway	KEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE	CYP11B1 CYP11B2 HSD11B2	1.11e-06	5	69	3	M47522
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2 HSD11B2	1.31e-05	10	69	3	M27076
Pathway	REACTOME_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2 HSD11B2	1.80e-05	11	69	3	MM14750
Pathway	WP_GLUCOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2 HSD11B2	3.93e-05	14	69	3	M46449
Pathway	WP_MINERALOCORTICOID_BIOSYNTHESIS	CYP11B1 CYP11B2 HSD11B2	3.93e-05	14	69	3	M46453
Pathway	WP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM	CYP11B1 CYP11B2 HSD11B2	6.00e-05	16	69	3	M39815
Pathway	REACTOME_ENDOGENOUS_STEROLS	CYP8B1 CYP11B1 CYP11B2	2.39e-04	25	69	3	M11184
Pathway	REACTOME_ENDOGENOUS_STEROLS	CYP8B1 CYP11B1 CYP11B2	3.02e-04	27	69	3	MM14844
Pubmed	Myeloid cells are capable of synthesizing aldosterone to exacerbate damage in muscular dystrophy.	CYP11B1 CYP11B2 HSD11B2	1.32e-06	8	101	3	27798095
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	MYBBP1A PIEZO1 PKMYT1 UBR5 CEBPZ PRKDC PCNT	2.82e-06	210	101	7	16565220
Pubmed	MRE11 complex links RECQ5 helicase to sites of DNA damage.	MCM7 UBR5 PRKDC	3.86e-06	11	101	3	19270065
Pubmed	Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure.	CYP11B1 CYP11B2 HSD11B2	3.86e-06	11	101	3	20486282
Pubmed	Maternal corticosterone exposure in the mouse has sex-specific effects on placental growth and mRNA expression.	CYP11B1 CYP11B2 HSD11B2	5.13e-06	12	101	3	22919064
Pubmed	Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.	CYP11B1 CYP11B2 HSD11B2	6.66e-06	13	101	3	24580729
Pubmed	Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.	CYP11B1 CYP11B2	8.35e-06	2	101	2	23150505
Pubmed	GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	8.35e-06	2	101	2	35012455
Pubmed	Role of genetic variation in regulation of aldosterone biosynthesis.	CYP11B1 CYP11B2	8.35e-06	2	101	2	21164264
Pubmed	MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo.	CIITA PRKDC	8.35e-06	2	101	2	16081800
Pubmed	Maid is a negative regulator of transforming growth factor-β-induced cell migration.	CCNDBP1 TGFB1	8.35e-06	2	101	2	26002959
Pubmed	The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.	CYP11B1 CYP11B2	8.35e-06	2	101	2	8645611
Pubmed	Delayed wound healing in immunodeficient TGF-beta 1 knockout mice.	TGFB1 PRKDC	8.35e-06	2	101	2	10886500
Pubmed	Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.	CYP11B1 CYP11B2	8.35e-06	2	101	2	12231255
Pubmed	A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.	CYP11B1 CYP11B2	8.35e-06	2	101	2	20634641
Pubmed	Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.	CYP11B1 CYP11B2	8.35e-06	2	101	2	1303253
Pubmed	Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.	CYP11B1 CYP11B2	8.35e-06	2	101	2	1741400
Pubmed	Host-derived TGFB1 deficiency suppresses lesion development in a mouse model of endometriosis.	TGFB1 PRKDC	8.35e-06	2	101	2	22210480
Pubmed	Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.	CYP11B1 CYP11B2	8.35e-06	2	101	2	32540969
Pubmed	Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.	CYP11B1 CYP11B2	8.35e-06	2	101	2	26047574
Pubmed	Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.	CYP11B1 CYP11B2	8.35e-06	2	101	2	26324851
Pubmed	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.	CYP11B1 CYP11B2	8.35e-06	2	101	2	7669222
Pubmed	Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.	CYP11B1 CYP11B2	8.35e-06	2	101	2	22933298
Pubmed	Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	8.35e-06	2	101	2	2783417
Pubmed	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.	CYP11B1 CYP11B2	8.35e-06	2	101	2	2256920
Pubmed	Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.	CYP11B1 CYP11B2	8.35e-06	2	101	2	20708777
Pubmed	Molecular genetic studies on the biosynthesis of aldosterone in humans.	CYP11B1 CYP11B2	8.35e-06	2	101	2	22217843
Pubmed	Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.	CYP11B1 CYP11B2	8.35e-06	2	101	2	16396990
Pubmed	[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.	CYP11B1 CYP11B2	8.35e-06	2	101	2	18397978
Pubmed	Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.	CYP11B1 CYP11B2	8.35e-06	2	101	2	1518866
Pubmed	Regulation of epithelial cell turnover and macrophage phenotype by epithelial cell-derived transforming growth factor beta1 in the mammary gland.	TGFB1 PRKDC	8.35e-06	2	101	2	23290315
Pubmed	Procollagen I-expressing renin cell precursors.	CYP11B1 CYP11B2	8.35e-06	2	101	2	23761669
Pubmed	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).	CYP11B1 CYP11B2	8.35e-06	2	101	2	2592361
Pubmed	Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.	CYP11B1 CYP11B2	8.35e-06	2	101	2	23314847
Pubmed	Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.	CYP11B1 CYP11B2	8.35e-06	2	101	2	17980006
Pubmed	Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.	CYP11B1 CYP11B2	8.35e-06	2	101	2	16984984
Pubmed	Evidence for local aldosterone synthesis in the large intestine of the mouse.	CYP11B1 CYP11B2	8.35e-06	2	101	2	35288482
Pubmed	Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.	CYP11B1 CYP11B2	8.35e-06	2	101	2	15731365
Pubmed	Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.	AVPR2 NPHP3	8.35e-06	2	101	2	28630289
Pubmed	Null mutation in transforming growth factor beta1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest.	TGFB1 PRKDC	8.35e-06	2	101	2	16269452
Pubmed	Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.	CYP11B1 CYP11B2	8.35e-06	2	101	2	17651452
Pubmed	Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.	CYP11B1 CYP11B2	8.35e-06	2	101	2	34743356
Pubmed	Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.	CYP11B1 CYP11B2	8.35e-06	2	101	2	20339375
Pubmed	Monogenic Hypertension in Children: A Review With Emphasis on Genetics.	CYP11B2 HSD11B2	8.35e-06	2	101	2	29229168
Pubmed	C2CD4A/B variants in the predisposition of lung cancer in the Chinese Han population.	C2CD4B C2CD4A	8.35e-06	2	101	2	35212842
Pubmed	Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.	C2CD4B C2CD4A	8.35e-06	2	101	2	33492421
Pubmed	Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects.	TGFB1 PRKDC	8.35e-06	2	101	2	18614704
Pubmed	Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.	CYP11B1 CYP11B2	8.35e-06	2	101	2	20808686
Pubmed	Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.	CYP11B1 CYP11B2	8.35e-06	2	101	2	21519965
Pubmed	A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.	C2CD4B C2CD4A	8.35e-06	2	101	2	29625024
Pubmed	Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.	CYP11B1 CYP11B2	8.35e-06	2	101	2	21625068
Pubmed	Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.	CYP11B1 CYP11B2	8.35e-06	2	101	2	16110193
Pubmed	Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.	CYP11B1 CYP11B2	8.35e-06	2	101	2	26066897
Pubmed	Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.	CYP11B1 CYP11B2	8.35e-06	2	101	2	18651133
Pubmed	A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.	CYP11B1 CYP11B2	8.35e-06	2	101	2	22083159
Pubmed	Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.	CYP11B1 CYP11B2	8.35e-06	2	101	2	15699546
Pubmed	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	CYP11B1 CYP11B2	8.35e-06	2	101	2	18162527
Pubmed	Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.	CYP11B1 CYP11B2	8.35e-06	2	101	2	38341019
Pubmed	Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.	CYP11B1 CYP11B2	8.35e-06	2	101	2	24837548
Pubmed	Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.	CYP11B1 CYP11B2	8.35e-06	2	101	2	30046010
Pubmed	Familial and phenotypic associations of the aldosterone Renin ratio.	CYP11B1 CYP11B2	8.35e-06	2	101	2	19820005
Pubmed	Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.	CYP11B1 CYP11B2	8.35e-06	2	101	2	22622494
Pubmed	Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.	CYP11B1 CYP11B2	8.35e-06	2	101	2	15062555
Pubmed	Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.	CYP11B1 CYP11B2	8.35e-06	2	101	2	17075030
Pubmed	Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.	CYP11B1 CYP11B2	8.35e-06	2	101	2	17075029
Pubmed	CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.	CYP11B1 CYP11B2	8.35e-06	2	101	2	15507509
Pubmed	Polymorphism of CYP11B2 determines salt sensitivity in Japanese.	CYP11B1 CYP11B2	8.35e-06	2	101	2	17296872
Pubmed	Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.	CYP11B1 CYP11B2	8.35e-06	2	101	2	18039983
Pubmed	Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.	CYP11B1 CYP11B2	8.35e-06	2	101	2	19029289
Pubmed	Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.	CYP11B1 CYP11B2	8.35e-06	2	101	2	15522937
Pubmed	Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure.	CYP11B1 CYP11B2 HSD11B2	1.30e-05	16	101	3	37727456
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	MYBBP1A CAND2 PSMC3 GALNT12 HSPBP1 FANCA THEM6 UBR5 CEBPZ PXMP2 LRP6 PRKDC	1.90e-05	942	101	12	31073040
Pubmed	Genome-wide association study identifies three novel loci for type 2 diabetes.	C2CD4B DUSP9 C2CD4A	2.23e-05	19	101	3	23945395
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	MYBBP1A PSMC3 MCM7 MDN1 UBR5 PRKDC	2.48e-05	197	101	6	31620119
Pubmed	The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.	CYP11B1 CYP11B2	2.50e-05	3	101	2	2546938
Pubmed	Kidney function in mice lacking aldosterone.	CYP11B1 CYP11B2	2.50e-05	3	101	2	16118390
Pubmed	Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.	CYP11B1 CYP11B2	2.50e-05	3	101	2	17984374
Pubmed	Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.	CYP11B1 CYP11B2	2.50e-05	3	101	2	2233742
Pubmed	Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system.	CYP11B1 CYP11B2	2.50e-05	3	101	2	33271253
Pubmed	The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.	CYP11B1 CYP11B2	2.50e-05	3	101	2	18801336
Pubmed	Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.	CYP11B1 CYP11B2	2.50e-05	3	101	2	11932209
Pubmed	The expansion of the PRAME gene family in Eutheria.	PRAMEF19 PRAMEF18	2.50e-05	3	101	2	21347312
Pubmed	Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.	CYP11B1 CYP11B2	2.50e-05	3	101	2	21467193
Pubmed	The 19S ATPase S6a (S6'/TBP1) regulates the transcription initiation of class II transactivator.	PSMC3 CIITA	2.50e-05	3	101	2	19853614
Pubmed	Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.	CYP11B1 CYP11B2	2.50e-05	3	101	2	7750493
Pubmed	Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis.	CYP11B1 CYP11B2	2.50e-05	3	101	2	26471128
Pubmed	Cell cycle arrest by transforming growth factor beta1 near G1/S is mediated by acute abrogation of prereplication complex activation involving an Rb-MCM interaction.	MCM7 TGFB1	2.50e-05	3	101	2	19948884
Pubmed	A novel gene family induced by acute inflammation in endothelial cells.	C2CD4B C2CD4A	2.50e-05	3	101	2	15527968
Pubmed	Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.	CYP11B1 CYP11B2	2.50e-05	3	101	2	28355486
Pubmed	Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.	CYP11B1 CYP11B2	2.50e-05	3	101	2	36861295
Pubmed	A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.	C2CD4B C2CD4A	2.50e-05	3	101	2	20818381
Pubmed	Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.	CYP11B1 CYP11B2	2.50e-05	3	101	2	36778748
Pubmed	Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.	CYP11B1 CYP11B2	2.50e-05	3	101	2	8111631
Pubmed	A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.	C2CD4B C2CD4A	2.50e-05	3	101	2	21799836
Pubmed	Sodium Channel Nav1.5 Controls Epithelial-to-Mesenchymal Transition and Invasiveness in Breast Cancer Cells Through its Regulation by the Salt-Inducible Kinase-1.	TGFB1 SCN5A	2.50e-05	3	101	2	31819138
Pubmed	Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells.	CYP11B1 CYP11B2	2.50e-05	3	101	2	10411633
Pubmed	Differential effects of high and low steroidogenic factor-1 expression on CYP11B2 expression and aldosterone production in adrenocortical cells.	CYP11B1 CYP11B2	2.50e-05	3	101	2	18974272
Pubmed	Changes in the expression of the type 2 diabetes-associated gene VPS13C in the β-cell are associated with glucose intolerance in humans and mice.	C2CD4B C2CD4A	2.50e-05	3	101	2	27329800
Pubmed	Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.	CYP11B1 CYP11B2	2.50e-05	3	101	2	1686470
Pubmed	Mislocalization of protein kinase A drives pathology in Cushing's syndrome.	CYP11B1 CYP11B2	2.50e-05	3	101	2	35830806
GeneFamily	Cytochrome P450 family 11	CYP11B1 CYP11B2	4.17e-05	3	68	2	1007
GeneFamily	AAA ATPases	KATNAL2 PSMC3 MDN1 CLPB	4.66e-05	53	68	4	413
GeneFamily	MAP kinase phosphatases	DUSP2 DUSP9	7.50e-04	11	68	2	895
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM4E	3.65e-03	24	68	2	485
GeneFamily	PRAME family	PRAMEF19 PRAMEF18	3.65e-03	24	68	2	686
GeneFamily	NLR family	NLRP1 CIITA	3.95e-03	25	68	2	666
Coexpression	HAY_BONE_MARROW_ERYTHROBLAST	TROAP PSMC3 MCM7 XK HSPBP1 SLC4A1 FANCA PKMYT1 THEM6 GRPEL1 MDN1 MRPL15 CLPB IFRD2 FBXO7 FADS2 PRKDC	5.97e-06	1271	100	17	M39197
Coexpression	TRAVAGLINI_LUNG_PROLIFERATING_NK_T_CELL	TROAP DUSP2 PSMC3 MCM7 PKMYT1 PXMP2	1.03e-05	129	100	6	M41687
Coexpression	GSE19825_NAIVE_VS_IL2RAHIGH_DAY3_EFF_CD8_TCELL_DN	MYBBP1A CAND2 SLC35C1 PSMC3 PIDD1 TGFB1 AP4B1	1.19e-05	200	100	7	M4300
Coexpression	GSE37533_UNTREATED_VS_PIOGLIZATONE_TREATED_CD4_TCELL_FOXP3_TRASDUCED_CD4_TCELL_DN	CYP8B1 PIEZO1 LRRC4C FANCA MALT1 CEBPZ	3.75e-05	162	100	6	M8995
CoexpressionAtlas	DevelopingKidney_e12.5_renal vesicle_emap-27679_k-means-cluster#2_top-relative-expression-ranked_1000	EMB DUSP9 GALNT12 ELL3 FANCA	9.44e-06	62	97	5	gudmap_developingKidney_e12.5_renal vesicle_1000_k2
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TROAP MCM7 FANCA PKMYT1 PXMP2 FADS2	3.49e-06	180	101	6	1c1b25f1d22518db5469707131510daae84716a3
ToppCell	droplet-Marrow-BM_(NON-STC)-30m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP9 GALNT12 THEM6 STOML1 FADS2 HS3ST1	3.72e-06	182	101	6	33afbb7c4352b03266501b1f4f0e751c12c7350d
ToppCell	droplet-Heart-nan-3m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNDBP1 CYP8B1 SLC4A1 FANCA CIITA	1.69e-05	140	101	5	ab90f6f30d89761687f8836e3d327d143ce49ed4
ToppCell	Healthy_donor-RBC\|World / disease group, cell group and cell class (v2)	KCNE5 XK SLC4A1 FBXO7 ASAH2B	2.36e-05	150	101	5	1e1a497ec4b048f7e9cc12dd5dd9aba7fedca9e1
ToppCell	Healthy_donor-RBC\|Healthy_donor / disease group, cell group and cell class (v2)	KCNE5 XK SLC4A1 FBXO7 ASAH2B	2.68e-05	154	101	5	e080d5104fe6f3f6ef617bbcdccf1332ab7231e1
ToppCell	PND28-Immune-Immune_Myeloid-Granulocytic-Basophil\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF219 CCDC88B SLC22A3 STOML1 HES7	2.93e-05	157	101	5	8c42af7aa1f1b6f4fe2f8d00a8b4a800f121e804
ToppCell	PND28-Immune-Immune_Myeloid-Granulocytic\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF219 CCDC88B SLC22A3 STOML1 HES7	2.93e-05	157	101	5	ee1be3c756b72fceac6b4ccb416dd4bd031a2193
ToppCell	PND28-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZNF219 CCDC88B SLC22A3 STOML1 HES7	2.93e-05	157	101	5	008f938a338f43c3251dcac574f1b4f689926c71
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TROAP EMB DUSP9 NLRP1 CIITA	3.03e-05	158	101	5	91d265e95156f16459924d3e4dd11c180e164eee
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMB DUSP9 PIDD1 CIITA HS3ST1	3.21e-05	160	101	5	e9e52532131cdc3fb01e81cfc046e3f670cc8e75
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMB DUSP9 NLRP1 GALNT12 CIITA	3.41e-05	162	101	5	93bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCell	PND10-Immune-Immune_Myeloid-DC-maDC-maDC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUSP2 SH2D5 KCNH3 HES7 PCSK1N	4.17e-05	169	101	5	a83e4078db91ecedee637b28b12ec38640fe45f9
ToppCell	PND10-Immune-Immune_Myeloid-DC-maDC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUSP2 SH2D5 KCNH3 HES7 PCSK1N	4.17e-05	169	101	5	f914aa8899fa170a09da31e5fad86de897ea789b
ToppCell	facs-Heart-LV-3m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C2CD4B DUSP2 ELL3 MALT1 FIBCD1	4.29e-05	170	101	5	2491f3849e34b0ccd06015fa59d15e3d7963c76d
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Red_blood_cells-RBC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCNDBP1 XK SLC4A1 FBXO7 CKMT1A	4.54e-05	172	101	5	acdc261001f63a8cfce1216ef1e33b4e034b1c11
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-Red_blood_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CCNDBP1 XK SLC4A1 FBXO7 CKMT1A	4.54e-05	172	101	5	8ccc3459dbdf103c631aa2a0defb8790c06ad6c1
ToppCell	droplet-Lung-1m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DTNB GALNT12 MCM7 XK TEDC1	4.66e-05	173	101	5	c399786aa25bdbe3394988db6955842b5b7e6b41
ToppCell	facs-MAT-Fat-18m-Lymphocytic-T_cell\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR2E3 EMB GALNT12 LTB4R2 LINGO4	4.66e-05	173	101	5	97391a763c17ce0107c9e2386e88c417ac75a72e
ToppCell	droplet-Fat-Mat-18m-Hematologic-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNDBP1 PIDD1 XK SLC4A1	5.04e-05	89	101	4	56039e126e6f3e8fcaf3c47237c980e514512536
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP8B1 DUSP2 CCDC88B FANCA CIITA	5.34e-05	178	101	5	ee674e379ee57e40eb2560ff5ed4c13d8db7ed9d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP8B1 DUSP2 CCDC88B FANCA CIITA	5.34e-05	178	101	5	6c45bf197d6c1be0ef7d3a644c0062acf1e24e4d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Myeloid-macrophage\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP8B1 DUSP2 CCDC88B FANCA CIITA	5.34e-05	178	101	5	cd85dcefe94ee742db64b63e105e13532321894a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TROAP MCM7 FANCA PKMYT1 TEDC1	5.48e-05	179	101	5	80112c686a8f85ad5e3cda6e3f3d3d51cf688092
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c14-MKI67-CCL5_h\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TROAP MCM7 FANCA PKMYT1 PXMP2	5.63e-05	180	101	5	42f48e646fc6e72ad3cce72409ace3a0b64020a2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP8B1 DUSP2 CCDC88B FANCA CIITA	5.63e-05	180	101	5	6ac62bf1251978c8c12e715f7b73144fca619794
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP9 GALNT12 THEM6 FADS2 HS3ST1	5.78e-05	181	101	5	fb64da1dde37fe6ba7de2586cd58848ac1974f24
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DUSP2 SHISA4 KCNH3 KCNU1 CKMT1A	6.25e-05	184	101	5	61caaa31975e05c9a6512079c791fed5a9e2d39f
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DUSP2 SHISA4 KCNH3 KCNU1 CKMT1A	6.25e-05	184	101	5	03da0f0f89f1ca5a3ccca1e22972f3129464e68e
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DUSP2 SHISA4 KCNH3 KCNU1 CKMT1A	6.25e-05	184	101	5	9ed2a65a4ca0ebbbb89ace61027522f93369843d
ToppCell	COVID-cycling-\|COVID / Condition, Cell_class and T cell subcluster	TROAP XK SLC4A1 FANCA PKMYT1	6.41e-05	185	101	5	eb74b8d36f7b749e04bc2ed4b36f7e1ac7bb6d5f
ToppCell	COVID-cycling\|COVID / Condition, Cell_class and T cell subcluster	TROAP XK SLC4A1 FANCA PKMYT1	6.41e-05	185	101	5	5112f966735fa48f0606adcfd5c0212ad5d3d77a
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.C1ql3_(Hippocampus_Excitatory_Neuron)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C2CD4B C2CD4A KCNH3 HES7	7.06e-05	97	101	4	1da964954a95c497ac4a24df1ea3575df5747025
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C2CD4B C2CD4A KCNH3 HES7	7.06e-05	97	101	4	dd188763ba02337e4f25d56766eda886cffa810d
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C2CD4B C2CD4A KCNH3 HES7	7.06e-05	97	101	4	a0242258aad0766450ff52fe28278cbb2b8d63a0
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.C1ql3_(Hippocampus_Excitatory_Neuron)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	C2CD4B C2CD4A KCNH3 HES7	7.06e-05	97	101	4	98a31b9bf0adcad1cb1d803bf7a23d49b4e1f2d5
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOL3 AVPR2 DUSP9 PDZD7 CKMT1A	7.27e-05	190	101	5	68ba1934b2b3f0cec8efd229fe1db6e8be8a26b0
ToppCell	facs-Marrow-KLS-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYBBP1A MCM7 HSPBP1 SH2D5 SLC22A3	7.27e-05	190	101	5	a513c1e7df62c28128c932a68b252ee8f0255172
ToppCell	PBMC-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	TROAP MCM7 PXMP2 FADS2 PRKDC	7.27e-05	190	101	5	84ee185939bdefb10705b621a70da27701eadcee
ToppCell	facs-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOL3 AVPR2 DUSP9 PDZD7 CKMT1A	7.27e-05	190	101	5	010d7d13a3c16e614c36720ef690a505b9f3f7aa
ToppCell	(04)_Pre-ciliated\|World / shred by cell type and Timepoint	KATNAL2 PIDD1 XK LRRC23 PCNT	7.45e-05	191	101	5	37cf121e6e80760c8519075b7845b9029958a988
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	TROAP PIEZO1 NLRP1 FANCA MDN1	7.64e-05	192	101	5	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	10x5'-bone_marrow\|World / Manually curated celltypes from each tissue	TROAP DUSP2 SLC4A1 PKMYT1 FADS2	7.64e-05	192	101	5	34777fa7dc001b6d601376a23aab995e2cec043c
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c14-MKI67-CCL5_h\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TROAP MCM7 FANCA PKMYT1 PXMP2	7.82e-05	193	101	5	cf680afddc08b6481f1b3eee9c57acfaebeac6f0
ToppCell	control-T/NK_proliferative\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TROAP MCM7 FANCA PKMYT1 PXMP2	7.82e-05	193	101	5	ecb4018a47d9a82bb999e0bc8b3dceabd97d1f0d
ToppCell	droplet-Fat-Mat-18m-Hematologic\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNDBP1 PIDD1 XK SLC4A1	7.95e-05	100	101	4	ea36e4ff513d66186b92e39c549e55c26609cb30
ToppCell	droplet-Fat-Mat-18m-Hematologic-erythroblast\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNDBP1 PIDD1 XK SLC4A1	7.95e-05	100	101	4	ceca7d9342e5ee7293f07edb815beee4eb010fe7
ToppCell	facs-Marrow-KLS-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCM7 SH2D5 SLC22A3 IFRD2 FADS2	8.02e-05	194	101	5	c9ebdcc2ea600975dade68a41fa65d1f8a5a5926
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TROAP MCM7 PKMYT1 THEM6 PXMP2	8.21e-05	195	101	5	be8db0a22ef8ce24819f790b0bd93670e73af76f
ToppCell	COVID-19-T_cells-Cycling_NK/T_cells\|COVID-19 / group, cell type (main and fine annotations)	TROAP SLC4A1 FANCA PKMYT1 PCNT	8.21e-05	195	101	5	764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCell	(4)_B_Hypermutation\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	TROAP MCM7 FANCA PKMYT1 PXMP2	8.21e-05	195	101	5	54d2acaff6be6b5604591bdbd7d769ac3e74f223
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-hematopoietic_progenitor-erythroid_progenitor_cell\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MCM7 XK IFRD2 FBXO7 PXMP2	8.41e-05	196	101	5	e994aa72b362a4f4930b94505a99c0a87e9b163c
ToppCell	severe_COVID-19-T/NK_proliferative\|World / disease group, cell group and cell class (v2)	TROAP MCM7 FANCA PKMYT1 PXMP2	8.62e-05	197	101	5	189d97a6c2ff8803db8cc05e205c9d88dac3911f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DUSP9 SCAND1 SERPING1 PCSK1N HSD11B2	8.62e-05	197	101	5	02cc9d39afefa5e5b6f5d93f9adc3a20050b70dd
ToppCell	COVID-19-COVID-19_Mild-Others-RBC\|COVID-19_Mild / Disease, condition lineage and cell class	CCNDBP1 XK ELL3 SLC4A1 FBXO7	8.62e-05	197	101	5	3bae601e5d9689ea57e923814af8cdcae690becc
ToppCell	21-Trachea-RBC\|Trachea / Age, Tissue, Lineage and Cell class	TROAP XK SLC4A1 PKMYT1 FBXO7	8.62e-05	197	101	5	9f8eb6305ade0654bbcd8f19963be0b64af083de
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TROAP MCM7 FANCA PKMYT1 PXMP2	8.62e-05	197	101	5	17bd2aef8d8792703973643ec9743efd546b7b69
ToppCell	21-Trachea-RBC-RBC\|Trachea / Age, Tissue, Lineage and Cell class	TROAP XK SLC4A1 PKMYT1 FBXO7	8.62e-05	197	101	5	4710b55806a618076a954190f519e49c55d300d3
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega\|Control_saline / Treatment groups by lineage, cell group, cell type	KATNAL2 SLC4A1 PSME4 IFRD2 FBXO7	8.83e-05	198	101	5	1a39a98beef68e1e6d3adc25270a3336fcc5baf4
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|Control_saline / Treatment groups by lineage, cell group, cell type	KATNAL2 SLC4A1 PSME4 IFRD2 FBXO7	8.83e-05	198	101	5	dd80fd9671ee863aebcf4c1023d3e004cc2ee709
ToppCell	severe_COVID-19-T/NK_proliferative\|severe_COVID-19 / disease group, cell group and cell class (v2)	TROAP MCM7 FANCA PKMYT1 PXMP2	8.83e-05	198	101	5	ed86b0247006befe55400c287d334d2202b470bd
ToppCell	Control_saline-Hematopoietic_Erythro-Megakary\|Control_saline / Treatment groups by lineage, cell group, cell type	KATNAL2 SLC4A1 PSME4 IFRD2 FBXO7	8.83e-05	198	101	5	cfc2a860bae883299987d3e374d0476ca20e1bdd
ToppCell	10x5'v1-week_12-13-Hematopoietic\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CCNDBP1 XK SLC4A1 IFRD2 FBXO7	8.83e-05	198	101	5	d02e1ff7f68dedaca1e367c7cade772e7b355f45
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Ciliated\|LPS_only / Treatment groups by lineage, cell group, cell type	KATNAL2 CCDC121 C1orf87 GALNT12 LRRC43	8.83e-05	198	101	5	6d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TROAP MCM7 FANCA PKMYT1 PXMP2	8.83e-05	198	101	5	6981cd5b1585c8ae6febdf0c4fb83067127f106c
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MCM7 XK FBXO7 PXMP2 FADS2	8.83e-05	198	101	5	8be58e41ae7870d268e7ce5ab937769e2ecb60d9
ToppCell	MS-Multiple_Sclerosis-Others-RBC\|Multiple_Sclerosis / Disease, condition lineage and cell class	CCNDBP1 XK SHISA4 SLC4A1 FBXO7	9.04e-05	199	101	5	b9e7549f67bc33284bacf9a160b3916651659809
ToppCell	mild_COVID-19-T/NK_proliferative\|mild_COVID-19 / disease group, cell group and cell class (v2)	TROAP MCM7 FANCA PKMYT1 PXMP2	9.04e-05	199	101	5	df2fcaf01b1b48632f84e7355ef21d20853f0664
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-T/NK_proliferative\|COVID-19_Mild / Disease, condition lineage and cell class	TROAP MCM7 FANCA PKMYT1 PXMP2	9.25e-05	200	101	5	6126a3bbafe2110fba0c1c4493035df4e8193d22
ToppCell	severe-T/NK_proliferative\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TROAP MCM7 FANCA PKMYT1 PXMP2	9.25e-05	200	101	5	9d6e7e2d6cfa8c96bbb5c187815df96ecaa5475c
ToppCell	control-T/NK_proliferative\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TROAP MCM7 FANCA PKMYT1 PXMP2	9.25e-05	200	101	5	1da366e35a05f73253629663eeea1fed4ebd7b52
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TROAP MCM7 FANCA PKMYT1 PXMP2	9.25e-05	200	101	5	562309f9ca4a73cea5ed1d85b516891545f3ae5f
ToppCell	severe-T/NK_proliferative\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TROAP MCM7 FANCA PKMYT1 PXMP2	9.25e-05	200	101	5	d341f4e500377a5bef82c24bf64704b981053336
ToppCell	mild-T/NK_proliferative\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TROAP MCM7 FANCA PKMYT1 PCNT	9.25e-05	200	101	5	63cc57b9331459efbb73051d174d198a3568b938
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_2\|E16.5-samps / Age Group, Lineage, Cell class and subclass	TROAP KCNH3 SLC4A1 NPHP3	1.28e-04	113	101	4	dc002185095590fc071b2f39259f8b87a757e174
ToppCell	mild_COVID-19-RBC\|World / disease group, cell group and cell class (v2)	TROAP XK SHISA4 SLC4A1	1.46e-04	117	101	4	85210be67ddc31903764b7fa6d7029d9656753d3
ToppCell	mild_COVID-19-RBC\|mild_COVID-19 / disease group, cell group and cell class (v2)	TROAP XK SHISA4 SLC4A1	1.61e-04	120	101	4	cccea760901558ec18d5cbb71c7971c5a51da571
ToppCell	wk_08-11-Hematologic-Meg-ery-Definitive_erythrocyte\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CCNDBP1 XK SLC4A1 FBXO7	2.25e-04	131	101	4	537a79ea2b5d6b3dc0444570b1acbceda59b0d7c
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PPP1R13L ULK3 MDN1 STOML1	2.46e-04	134	101	4	64979e1a056b7406e1be39c5ebe2f8d731ac3c17
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT12 KCNE5 PXMP2 EXOC3L1	2.75e-04	138	101	4	6b83c434895d82eaf3c222eef27acec76f9c0a77
ToppCell	Endothelial-Endothelial-H_(cycle)\|Endothelial / shred on cell class and cell subclass (v4)	TROAP GALNT12 C2CD4A HES7	2.75e-04	138	101	4	a1f41a5a9da40adcc343722baef78c603599c3f0
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefm_(MGE-derived_cortical_interneurons--basket_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	NR2E3 AVPR2 CYP11B1	2.79e-04	56	101	3	ac776a6e8d0b5596dc492a05235e518cbfc7b5ed
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb-Inhibitory_Neuron.Gad1Gad2.Pvalb-Nefm_(MGE-derived_cortical_interneurons--basket_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	NR2E3 AVPR2 CYP11B1	2.79e-04	56	101	3	0417516b9241a756fb2bcd611691c675ca98030d
ToppCell	droplet-Heart-4Chambers-18m-Hematologic-erythrocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCNDBP1 SLC4A1 PKMYT1	2.79e-04	56	101	3	64bb7d3632b14452b6b861f73880b1dab729a0cf
ToppCell	LPS_only-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NLRP1 XK SLC4A1 PKMYT1	2.82e-04	139	101	4	d96e5c17582f1576fa09d6bad35c418b6248448c
ToppCell	10x5'v1-week_12-13-Hematopoietic-erythroid-late_erythroid\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CCNDBP1 XK SLC4A1 FBXO7	3.23e-04	144	101	4	ca365380ccf5e60d2e3f6272059ff0531759612d
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	XK SLC4A1 FIBCD1 LINGO4	3.40e-04	146	101	4	03a6a442f1f6d173a41aeebbfe41ee08853d9585
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1\|Striatum / BrainAtlas - Mouse McCarroll V32	DUSP2 KCNH3 SLC22A3 FIBCD1	3.40e-04	146	101	4	7b863f9bc63dc1afe015a18a70cd6ed0b71d1f09
ToppCell	facs-Lung-ENDOMUCIN-18m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NLRP1 GALNT12 CCDC88B CIITA	3.96e-04	152	101	4	87a7116d0064a6051bdf28ce1e48bfc168273e66
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NPHP3 CEBPZ UCN PCNT	3.96e-04	152	101	4	5adcdf93fd3ca066402aaaf308c363e4648f871d
ToppCell	10x5'v1-week_12-13-Hematopoietic-HSC/MPP_and_pro-myeloid_DC_progenitor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	KCNE5 LRRC43 IFRD2 SERPING1	3.96e-04	152	101	4	bffbbdf1047c59e5241c99dc10b36cfe2071aa48
ToppCell	NS-critical-d_16-33-Myeloid-Monocyte-derived_Macrophage\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KDM4E CLPB SERPING1 EXOC3L1	4.06e-04	153	101	4	859de35b24c5d7d73be1c213b90b43362ee2e0eb
ToppCell	Ciliated_cells-A-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	C1orf87 DUSP9 LRRC43 SCN5A	4.16e-04	154	101	4	3b938e23324f7edb56797b4a76fb96ff588142cf
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUSP2 MCM7 STOML1 TEDC1	4.37e-04	156	101	4	6f8622716bad4e505f241a2a4ef953bf3fc6dbfa
ToppCell	PND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PIDD1 PKMYT1 CIITA TEDC1	4.37e-04	156	101	4	af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP9 PIDD1 SH2D5 HS3ST1	4.48e-04	157	101	4	fc127e7720649e746f3d3f5c2e9e63784767106a
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-plasmacytoid_dendritic_cells\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP9 PIDD1 SH2D5 HS3ST1	4.48e-04	157	101	4	66a191cef4aa00811bb04462310d012610006f85
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-5\|TCGA-Stomach / Sample_Type by Project: Shred V9	DUSP9 PDZD7 LRRC43 SCN5A	4.70e-04	159	101	4	c40fe552da3abdb1df87e9e1647468dc038bec0a
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMB NLRP1 CCDC88B SH2D5	4.70e-04	159	101	4	cdbccb83af6220bab300dfe56443ff69f6e2043a
ToppCell	Mild-Lymphoid-Plasma\|Mild / Condition, Lineage, Cell class and cell subclass	TROAP PKMYT1 MIXL1 FADS2	4.81e-04	160	101	4	7fdb849f5caf5a127a2582326215e11f8eb4fa0e
ToppCell	LPS-IL1RA-Myeloid-Dendritic_cells-pDC\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NLRP1 ELL3 PCSK1N HS3ST1	4.81e-04	160	101	4	dee756a2dc9725520d439e7273c489c2284015d8
Drug	11 alpha-hydroxyprogesterone	CYP11B1 CYP11B2 PKN1 HSD11B2	1.61e-06	20	100	4	CID000092730
Disease	P wave duration	CAND2 EMB SCN5A FADS2	1.40e-07	15	96	4	EFO_0005094
Disease	Glucocorticoid-remediable aldosteronism	CYP11B1 CYP11B2	1.05e-05	2	96	2	C1260386
Disease	adrenal cortical adenoma (is_marker_for)	CYP11B1 CYP11B2	1.05e-05	2	96	2	DOID:0050891 (is_marker_for)
Disease	Xerocytosis	PIEZO1 SLC4A1	3.14e-05	3	96	2	C0272051
Disease	renal tubular acidosis (biomarker_via_orthology)	CYP11B1 SLC4A1	3.14e-05	3	96	2	DOID:14219 (biomarker_via_orthology)
Disease	congenital adrenal hyperplasia (implicated_via_orthology)	CYP11B1 CYP11B2	3.14e-05	3	96	2	DOID:0050811 (implicated_via_orthology)
Disease	Paroxysmal familial ventricular fibrillation	KCNE5 SCN5A	6.26e-05	4	96	2	C0340493
Disease	hypertension (implicated_via_orthology)	AVPR2 CYP11B1 CYP11B2 TGFB1 HSD11B2	6.33e-05	128	96	5	DOID:10763 (implicated_via_orthology)
Disease	primary hyperaldosteronism (is_implicated_in)	CYP11B1 CYP11B2	1.04e-04	5	96	2	DOID:446 (is_implicated_in)
Disease	Conn Syndrome	CYP11B1 CYP11B2	1.56e-04	6	96	2	C1384514
Disease	Hyperaldosteronism	CYP11B1 CYP11B2	1.56e-04	6	96	2	C0020428
Disease	protocadherin alpha-7 measurement	CYP11B1 CYP11B2	2.18e-04	7	96	2	EFO_0801973
Disease	skeletal age	CYP11B1 FANCA	2.18e-04	7	96	2	EFO_0020898
Disease	Hematological Disease	XK SLC4A1	2.90e-04	8	96	2	C0018939
Disease	premature birth, parental genotype effect measurement	TGFB1 PXMP2	3.72e-04	9	96	2	EFO_0003917, EFO_0005939
Disease	protein FAM163B measurement	CYP11B1 CYP11B2	3.72e-04	9	96	2	EFO_0802936
Disease	familial hyperlipidemia	CCDC121 INTS10 SLC22A3 ASAH2B	4.05e-04	106	96	4	MONDO_0001336
Disease	androstenedione measurement	CYP11B1 CYP11B2	4.63e-04	10	96	2	EFO_0007972
Disease	cell growth regulator with EF hand domain protein 1 measurement	CYP11B1 CYP11B2	5.65e-04	11	96	2	EFO_0801461
Disease	3-hydroxyanthranilate 3,4-dioxygenase measurement	CYP11B1 CYP11B2	5.65e-04	11	96	2	EFO_0021862
Disease	Diabetes Mellitus, Non-Insulin-Dependent	C2CD4B C2CD4A TGFB1 KCNU1 SLC22A3	7.92e-04	221	96	5	C0011860
Disease	breast cancer (is_implicated_in)	FANCA TGFB1 UBR5 RASSF1	1.48e-03	150	96	4	DOID:1612 (is_implicated_in)
Disease	triglyceride measurement, body fat percentage	KCNU1 SLC22A3	2.11e-03	21	96	2	EFO_0004530, EFO_0007800
Disease	osteoporosis (biomarker_via_orthology)	TGFB1 CSHL1	2.32e-03	22	96	2	DOID:11476 (biomarker_via_orthology)
Disease	BMI-adjusted fasting blood glucose measurement	C2CD4B FADS2	2.53e-03	23	96	2	EFO_0008036
Disease	level of Sphingomyelin (d40:2) in blood serum	PKMYT1 FADS2	2.53e-03	23	96	2	OBA_2045181
Disease	monocyte percentage of leukocytes	CYP8B1 PIEZO1 FANCA GRPEL1 CIITA SLC22A3 FADS2 PRKDC	2.67e-03	731	96	8	EFO_0007989
Disease	Brugada Syndrome (disorder)	KCNE5 SCN5A	2.76e-03	24	96	2	C1142166
Disease	diacylglycerol 34:2 measurement	INTS10 FADS2	2.99e-03	25	96	2	EFO_0010353
Disease	apolipoprotein L1 measurement	CYP11B1 CYP11B2	2.99e-03	25	96	2	EFO_0021854
Disease	colon adenocarcinoma (is_implicated_in)	TGFB1 UBR5	3.24e-03	26	96	2	DOID:234 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VLLALRELLNLRDPA	EXOC3L1	646	Q86VI1
RTSLLLLRLNDAALR	ELL3	21	Q9HB65
RLAELLLEREPLCLR	CCDC88B	226	A6NC98
RPQDREELLRALLLK	SLC4A1	146	P02730
QDRALTLLRDRPLLL	CIITA	591	P33076
ETLLRLLLRIVDRAP	ASAH2B	21	P0C7U1
LLTALLRLFLSRPAE	AP4B1	476	Q9Y6B7
LLLIESRLEPVRFLR	CSHL1	111	Q14406
LQELEALLLRSRDPR	BTBD11	101	A6QL63
DLRDLLLFLAERLPT	CCDC22	96	O60826
AARALLQLLRSDLRL	HSD11B2	16	P80365
RLLEKQLSEPDRRLL	CCDC121	151	Q6ZUS5
FLLALVRRELKSRPL	C1orf87	176	Q8N0U7
RLSRLLLRLPALRLM	NR2C1	546	P13056
LLLLLPSLRFITAER	NR2E3	371	Q9Y5X4
RKLLDDEQPLRLRLL	RASSF1	261	Q9NS23
LERSEMLLLLLRRFP	INTS10	126	Q9NVR2
TVRLLRLLRLLPRLD	KCNH3	336	Q9ULD8
EKPLLRALLDIIRSL	FADS2	416	O95864
VGRQLRPLLLDLLER	MDN1	61	Q9NU22
NRLREPLLRRLSELL	MALT1	31	Q9UDY8
VRLARRSLPALALSL	GRPEL1	6	Q9HAV7
LELTRLLPLRFVRIS	GARIN4	116	Q8IYT1
SQRLRTLLSRLLLEL	KCNE5	6	Q9UJ90
LDPLLSALRLDSSRL	HPS5	21	Q9UPZ3
LLRVPDGLLSRALRA	C2CD4B	176	A6NLJ0
TLLRDPREAERTLLL	DUSP2	16	Q05923
VLACLLPDRALRTRL	DUSP2	66	Q05923
LRDLPKLRALVLLDN	LRRC23	266	Q53EV4
LARALLRARLDPAAL	PCSK1N	136	Q9UHG2
LRRLEKRILVDLPSR	KATNAL2	411	Q8IYT4
LDRPEKLLLLQDIRS	PDZD7	601	Q9H5P4
TLRRPRCLLETLRLA	NLRP1	831	Q9C000
ALRFIRLEPLRALLE	PRAMEF18	331	Q5VWM3
ALSVALPALLLRRLR	DUSP9	41	Q99956
DIVLRRAALGLRLLP	KDM4E	361	B2RXH2
LLLARRTDLRRISLD	LRP6	331	O75581
LPALADDILQLSRRR	MIGA2	546	Q7L4E1
RFLRALRLLELPQIL	KCNU1	196	A8MYU2
IPSLRRLDLGELKRL	LRRC4C	171	Q9HCJ2
LEAVLLALARIRRAL	PCNT	1891	O95613
DRKLPAIALDLLRLA	MYBBP1A	261	Q9BQG0
LELLEPLLSIIRRSL	MYBBP1A	846	Q9BQG0
LLAILRLSTALARLR	MCM7	606	P33993
SLRLDLRVARSVLPL	SLC35C1	106	Q96A29
LERRSLLSILPVLAL	GFRA4	281	Q9GZZ7
LRHLAEELRLLLPRV	CCNDBP1	21	O95273
PLELKLRIFRLLDVR	FBXO7	336	Q9Y3I1
SDLRLGRLLLRVAPD	FANCA	1311	O15360
ELPLLRAALKETLRL	CYP11B1	361	P15538
PTLLAELRLLRQRKD	DTNB	476	O60941
PRELRRGREALLVLL	GALNT12	11	Q8IXK2
RLLDSLPSDTRLVLL	SERPING1	276	P05155
ALASRLLPDFLLERR	IFRD2	166	Q12894
LLPDFLLERRLTLAD	IFRD2	171	Q12894
LLDTLADQLPRLLAR	FIBCD1	136	Q8N539
ALAPRLLLRLLRSPT	CLPB	11	Q9H078
ELPLLRAALKETLRL	CYP11B2	361	P19099
GLLEARARTPRLLLL	EMB	6	Q6PCB8
DRINRSLEELRLLLL	HES7	26	Q9BYE0
EPTLLLLLDRLRNEI	CAND2	611	O75155
LLLDRLRNEITRLPA	CAND2	616	O75155
LILLTIERLGRRLPF	SLC22A3	396	O75751
RRARLNPLVLLLDAA	PPP1R13L	621	Q8WUF5
LLRVPDGLLSRALRA	C2CD4A	181	Q8NCU7
ELLITDLLPDNRKLR	CEBPZ	291	Q03701
ETLRLRAAPTLLRLV	CYP8B1	346	Q9UNU6
SRLLSARPGLRLLAL	CKMT1A	6	P12532
AEELAKLRLRIDPRL	LRRC43	431	Q8N309
ARLPALVALRLRELD	LINGO4	201	Q6UY18
LVALRLRELDIGRLP	LINGO4	206	Q6UY18
RLPLLTRLDLRDNQL	PIDD1	261	Q9HB75
RLLLILRDPSERVLS	HS3ST1	141	O14792
LGALRKLLRLLDRDA	HSPBP1	186	Q9NZL4
LARFEQLISRRPLLL	XAB2	331	Q9HCS7
RALDLLRGLPRVSLA	MRPL15	11	Q9P015
LRLLEPFEVRTRLLG	THEM6	111	Q8WUY1
RLAFLPLDLGRSREL	LRRC28	191	Q86X40
RLRSPALARRLLLAV	LTB4R2	131	Q9NPC1
ALLRRRALQLEELTL	NPHP3	1071	Q7Z494
TLRFIRLEPLRALLE	PRAMEF19	331	Q5SWL8
LLAILPEAARARRIR	SCAND1	156	P57086
ISRPCALALLRRDVL	SH2D5	301	Q6ZV89
SLRTLRALRPLRALS	SCN5A	1301	Q14524
LRRAAPLTAIALLVL	SHISA4	6	Q96DD7
LPDAERRVRRLLLLV	NOL3	51	O60936
LLREALERRLGELPA	PKN1	266	Q16512
LLELRDISGRLLREV	SPATA9	101	Q9BWV2
RERLAALTLLPESRI	MIXL1	116	Q9H2W2
EVPLAGLRRLLLDRL	PXMP2	101	Q9NR77
GLRRLLLDRLVFAPA	PXMP2	106	Q9NR77
LRATAEALLALPVLR	PKMYT1	346	Q99640
EADLRALLCRELRPL	STOML1	356	Q9UBI4
DILDPALLRSGRLDR	PSMC3	336	P17980
EPVLLSRAELRLLRL	TGFB1	146	P01137
LLSPFRALLRTLERE	TEDC1	291	Q86SX3
LSNLAPRTLALRERL	TROAP	701	Q12815
LEPLQERRRLLLASK	SPTBN4	1501	Q9H254
LSLLLRDDRVLPLRA	PSME4	1171	Q14997
RLLEEALLRLLPAEL	PRKDC	2891	P78527
SELLLDRRLRIPELE	PIEZO1	1646	Q92508
ARALLLLLAERFPRR	UCN	51	P55089
DLSRDRPLVLLLHLL	XK	61	P51811
AARLLLELEERALLR	ZNF219	116	Q9P2Y4
TRDPLLARAELALLS	AVPR2	31	P30518
VLLLPLERDSELLRE	UBR5	296	O95071
RPLLSRDCRDLLQRL	ULK3	236	Q6PHR2
RRPRLETILALLVAL	KDM5C	1251	P41229