Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP:ADP antiporter activity

SLC25A4 SLC25A5 SLC25A6

1.99e-0651183GO:0005471
GeneOntologyMolecularFunctionADP transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

3.21e-05111183GO:0015217
GeneOntologyMolecularFunctionNEDD8 activating enzyme activity

UBA3 NAE1

3.46e-0521182GO:0019781
GeneOntologyMolecularFunctionprotein serine kinase activity

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

5.96e-0536311810GO:0106310
GeneOntologyMolecularFunctionATP transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

6.98e-05141183GO:0005347
GeneOntologyMolecularFunctionprotein serine/threonine kinase activity

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

3.18e-0444611810GO:0004674
GeneOntologyMolecularFunctionpurine ribonucleotide transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

3.27e-04231183GO:0005346
GeneOntologyMolecularFunctionadenine transmembrane transporter activity

SLC25A4 SLC25A5

3.42e-0451182GO:0015207
GeneOntologyMolecularFunctionoxidative phosphorylation uncoupler activity

SLC25A4 SLC25A5

3.42e-0451182GO:0017077
GeneOntologyMolecularFunctionadenine nucleotide transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

4.74e-04261183GO:0000295
GeneOntologyMolecularFunctionpurine nucleotide transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

6.57e-04291183GO:0015216
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

RAB31 RAB22A RAB1C KIF12 ABCA10 RHOU TUFM NLRP3 GSPT1 RAB10 RAB21 HSPA2 ABCC10

6.69e-0477511813GO:0017111
GeneOntologyMolecularFunctionthioredoxin-disulfide reductase (NADPH) activity

TXNRD2 TXNRD3

7.13e-0471182GO:0004791
GeneOntologyMolecularFunctiontranslation termination factor activity

GSPT1 MTRF1

7.13e-0471182GO:0008079
GeneOntologyMolecularFunctiontranslation release factor activity

GSPT1 MTRF1

7.13e-0471182GO:0003747
GeneOntologyMolecularFunctionglutamate-gated calcium ion channel activity

GRIN2C GRIN2D

9.47e-0481182GO:0022849
GeneOntologyMolecularFunctionNMDA glutamate receptor activity

GRIN2C GRIN2D

9.47e-0481182GO:0004972
GeneOntologyMolecularFunctionGTPase activity

RAB31 RAB22A RAB1C RHOU TUFM GSPT1 RAB10 RAB21

9.57e-043411188GO:0003924
GeneOntologyMolecularFunctionnucleotide transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

9.64e-04331183GO:0015215
GeneOntologyMolecularFunctionprotein-disulfide reductase (NAD(P)H) activity

TXNRD2 TXNRD3

1.21e-0391182GO:0047134
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

STK36 POLD1 STK32B STK32C STK35 STK32A POLR3B LATS1 LATS2 CSNK1G1 POLI NT5C2 AKT1 PKN3

1.28e-0393811814GO:0016772
GeneOntologyMolecularFunctionpyrophosphatase activity

RAB31 RAB22A RAB1C KIF12 ABCA10 RHOU TUFM NLRP3 GSPT1 RAB10 RAB21 HSPA2 ABCC10

1.38e-0383911813GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

RAB31 RAB22A RAB1C KIF12 ABCA10 RHOU TUFM NLRP3 GSPT1 RAB10 RAB21 HSPA2 ABCC10

1.39e-0384011813GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

RAB31 RAB22A RAB1C KIF12 ABCA10 RHOU TUFM NLRP3 GSPT1 RAB10 RAB21 HSPA2 ABCC10

1.39e-0384011813GO:0016818
GeneOntologyMolecularFunctionpurine nucleobase transmembrane transporter activity

SLC25A4 SLC25A5

1.51e-03101182GO:0005345
GeneOntologyMolecularFunctionubiquitin-like modifier activating enzyme activity

UBA3 NAE1

1.51e-03101182GO:0008641
GeneOntologyMolecularFunctionorganophosphate ester transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

1.57e-03391183GO:0015605
GeneOntologyMolecularFunctionligase activity, forming carbon-sulfur bonds

UBA3 ACSF2 NAE1

1.82e-03411183GO:0016877
GeneOntologyMolecularFunctionnucleobase transmembrane transporter activity

SLC25A4 SLC25A5

1.84e-03111182GO:0015205
GeneOntologyMolecularFunctiontransferase activity, transferring one-carbon groups

CARM1 TRMT9B RNMT GART METTL18 NNMT

2.16e-032241186GO:0016741
GeneOntologyMolecularFunctionoxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

TXNRD2 TXNRD3

2.20e-03121182GO:0016668
GeneOntologyMolecularFunctionGTP binding

RAB31 RAB22A RAB1C RHOU TUFM GSPT1 RAB10 RAB21

2.49e-033971188GO:0005525
GeneOntologyMolecularFunctionprotein kinase activity

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

2.97e-0360011810GO:0004672
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 NT5C2 AKT1 PKN3

3.21e-0370911811GO:0016773
GeneOntologyMolecularFunctionGDP binding

RAB31 RAB22A RAB10 RAB21

3.27e-031031184GO:0019003
GeneOntologyMolecularFunctionN-methyltransferase activity

CARM1 RNMT METTL18 NNMT

3.50e-031051184GO:0008170
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

CARM1 TRMT9B RNMT METTL18 NNMT

3.58e-031721185GO:0008757
GeneOntologyMolecularFunction3'-5'-DNA exonuclease activity

POLD1 EXD2

3.94e-03161182GO:0008296
GeneOntologyMolecularFunctionFMN binding

PPCDC HAO2

3.94e-03161182GO:0010181
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIN2C GRIN2D

4.44e-03171182GO:0004970
GeneOntologyMolecularFunctionguanyl ribonucleotide binding

RAB31 RAB22A RAB1C RHOU TUFM GSPT1 RAB10 RAB21

4.57e-034391188GO:0032561
GeneOntologyMolecularFunctionguanyl nucleotide binding

RAB31 RAB22A RAB1C RHOU TUFM GSPT1 RAB10 RAB21

4.57e-034391188GO:0019001
GeneOntologyMolecularFunctionoxidoreductase activity, acting on a sulfur group of donors

TXNRD2 PCYOX1L TXNRD3

4.67e-03571183GO:0016667
GeneOntologyMolecularFunctioncarbohydrate derivative transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

5.14e-03591183GO:1901505
GeneOntologyMolecularFunctionnucleobase-containing compound transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6

5.14e-03591183GO:0015932
GeneOntologyMolecularFunctioncadherin binding involved in cell-cell adhesion

ANXA1 RAB10

5.54e-03191182GO:0098641
GeneOntologyMolecularFunctionkinase activity

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 NT5C2 AKT1 PKN3

5.59e-0376411811GO:0016301
GeneOntologyMolecularFunctionnuclear import signal receptor activity

TNPO2 KPNB1

6.14e-03201182GO:0061608
GeneOntologyBiologicalProcessmitochondrial ADP transmembrane transport

SLC25A4 SLC25A5 SLC25A6

1.72e-0651163GO:0140021
GeneOntologyBiologicalProcessmitochondrial ATP transmembrane transport

SLC25A4 SLC25A5 SLC25A6

9.51e-0681163GO:1990544
GeneOntologyBiologicalProcessnucleotide transmembrane transport

LRRC8E SLC25A4 SLC25A5 SLC25A6

2.66e-05311164GO:1901679
GeneOntologyBiologicalProcessmitochondrial transmembrane transport

COL6A1 SLC25A4 SLC25A5 SLC25A6 SLC25A1 AKT1

3.00e-051061166GO:1990542
GeneOntologyBiologicalProcessADP transport

SLC25A4 SLC25A5 SLC25A6

3.67e-05121163GO:0015866
GeneOntologyBiologicalProcesspeptidyl-serine phosphorylation

ANGPT1 STK32B STK32C STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

6.04e-053071169GO:0018105
GeneOntologyBiologicalProcesspurine-containing compound transmembrane transport

LRRC8E SLC25A4 SLC25A5 SLC25A6

7.42e-05401164GO:0072530
GeneOntologyBiologicalProcesspurine ribonucleotide transport

LRRC8E SLC25A4 SLC25A5 SLC25A6

7.42e-05401164GO:0015868
GeneOntologyBiologicalProcessnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

SLC25A4 SLC25A5 SLC25A6

7.51e-05151163GO:1901029
GeneOntologyBiologicalProcesspeptidyl-serine modification

ANGPT1 STK32B STK32C STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

8.10e-053191169GO:0018209
GeneOntologyBiologicalProcessadenine nucleotide transport

LRRC8E SLC25A4 SLC25A5 SLC25A6

9.01e-05421164GO:0051503
GeneOntologyBiologicalProcessinner cell mass cell fate commitment

LATS1 LATS2

9.37e-0531162GO:0001827
GeneOntologyBiologicalProcessinner cell mass cellular morphogenesis

LATS1 LATS2

9.37e-0531162GO:0001828
GeneOntologyBiologicalProcesspurine nucleotide transport

LRRC8E SLC25A4 SLC25A5 SLC25A6

1.08e-04441164GO:0015865
GeneOntologyBiologicalProcessmammary gland epithelial cell differentiation

PTCH1 LATS1 AKT1

1.57e-04191163GO:0060644
GeneOntologyBiologicalProcessmacromolecule methylation

CARM1 TRMT9B RNMT GSPT1 METTL18 AKT1

1.71e-041451166GO:0043414
GeneOntologyBiologicalProcessnucleotide transport

LRRC8E SLC25A4 SLC25A5 SLC25A6

1.79e-04501164GO:0006862
GeneOntologyBiologicalProcessmulticellular organismal locomotion

COL6A1 NPPC

1.87e-0441162GO:0071965
GeneOntologyBiologicalProcessnegative regulation of mitochondrial membrane permeability

SLC25A4 SLC25A5 SLC25A6

2.83e-04231163GO:0035795
GeneOntologyBiologicalProcessATP transport

SLC25A4 SLC25A5 SLC25A6

2.83e-04231163GO:0015867
GeneOntologyBiologicalProcessregulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

SLC25A4 SLC25A5 SLC25A6

3.22e-04241163GO:1901028
GeneOntologyBiologicalProcessmethylation

CARM1 TRMT9B RNMT GSPT1 METTL18 AKT1 NNMT

3.62e-042341167GO:0032259
GeneOntologyBiologicalProcessnegative regulation of membrane permeability

SLC25A4 SLC25A5 SLC25A6

4.10e-04261163GO:1905709
DomainAden_trnslctor

SLC25A4 SLC25A5 SLC25A6 SLC25A1

2.49e-05281154IPR002113
DomainMit_carrier

SLC25A4 SLC25A5 SLC25A6 SLC25A1

4.29e-05321154IPR002067
DomainMit_uncoupling

SLC25A4 SLC25A5 SLC25A6

4.80e-05121153IPR002030
DomainSer/Thr_kinase_AS

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

7.23e-0535711510IPR008271
DomainS_TKc

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

7.57e-0535911510SM00220
DomainPkinase_C

LATS1 LATS2 AKT1 PKN3

7.70e-05371154IPR017892
DomainPROTEIN_KINASE_ST

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

8.11e-0536211510PS00108
DomainThioredoxin/glutathione_Rdtase

TXNRD2 TXNRD3

1.12e-0431152IPR006338
DomainPkinase

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

1.24e-0438111510PF00069
DomainPkinase_C

LATS1 LATS2 AKT1 PKN3

1.27e-04421154PF00433
DomainSOLCAR

SLC25A4 SLC25A5 SLC25A6 SLC25A1

3.16e-04531154PS50920
Domain-

SLC25A4 SLC25A5 SLC25A6 SLC25A1

3.16e-045311541.50.40.10
DomainMitochondrial_sb/sol_carrier

SLC25A4 SLC25A5 SLC25A6 SLC25A1

3.16e-04531154IPR018108
DomainMito_carr

SLC25A4 SLC25A5 SLC25A6 SLC25A1

3.16e-04531154PF00153
DomainMt_carrier_dom

SLC25A4 SLC25A5 SLC25A6 SLC25A1

3.16e-04531154IPR023395
DomainLRR_6

NLRP3 NLRP14 LRRC31 FBXL20

3.65e-04551154PF13516
DomainPyr_OxRdtase_I_AS

TXNRD2 TXNRD3

3.71e-0451152IPR012999
DomainPyr_redox_dim

TXNRD2 TXNRD3

3.71e-0451152PF02852
DomainPYRIDINE_REDOX_1

TXNRD2 TXNRD3

3.71e-0451152PS00076
DomainAGC-kinase_C

LATS1 LATS2 AKT1 PKN3

3.91e-04561154IPR000961
DomainAGC_KINASE_CTER

LATS1 LATS2 AKT1 PKN3

3.91e-04561154PS51285
DomainS_TK_X

LATS1 LATS2 AKT1 PKN3

3.91e-04561154SM00133
DomainPROTEIN_KINASE_ATP

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

5.44e-0445911510PS00107
DomainProtein_kinase_ATP_BS

STK36 STK32B STK32C STK35 STK32A LATS2 CSNK1G1 AKT1 PKN3

5.63e-043791159IPR017441
DomainUBA-like

LATS1 LATS2 DMRT3 NT5C2

6.52e-04641154IPR009060
Domain-

TXNRD2 TXNRD3

7.74e-04711523.30.390.30
Domain-

CARM1 TRMT9B RNMT METTL18 NNMT

8.80e-0412011553.40.50.150
DomainProt_kinase_dom

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

8.85e-0448911510IPR000719
DomainPROTEIN_KINASE_DOM

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

9.41e-0449311510PS50011
DomainSAM-dependent_MTases

CARM1 TRMT9B RNMT METTL18 NNMT

9.48e-041221155IPR029063
DomainPyr_nucl-diS_OxRdtase_dimer

TXNRD2 TXNRD3

1.03e-0381152IPR004099
DomainTransl_elong_EFTu/EF1A_C

TUFM GSPT1

1.03e-0381152IPR004160
DomainFAD/NAD-linked_Rdtase_dimer

TXNRD2 TXNRD3

1.03e-0381152IPR016156
DomainGTP_EFTU_D3

TUFM GSPT1

1.03e-0381152PF03143
DomainRAB

RAB31 RAB22A RAB10 RAB21

1.07e-03731154PS51419
DomainG_TR_CS

TUFM GSPT1

1.32e-0391152IPR031157
DomainRas

RAB31 RAB22A RHOU RAB10 RAB21

1.54e-031361155PF00071
DomainThiF_NAD_FAD-bd

UBA3 NAE1

1.64e-03101152IPR000594
DomainTransl_elong_EF1A/Init_IF2_C

TUFM GSPT1

1.64e-03101152IPR009001
DomainThiF

UBA3 NAE1

1.64e-03101152PF00899
DomainKinase-like_dom

STK36 STK32B STK32C STK35 STK32A LATS1 LATS2 CSNK1G1 AKT1 PKN3

1.91e-0354211510IPR011009
DomainG_TR_1

TUFM GSPT1

2.80e-03131152PS00301
DomainSmall_GTPase

RAB31 RAB22A RHOU RAB10 RAB21

3.12e-031601155IPR001806
DomainHEAT

STK36 TNPO2 KPNB1

3.21e-03481153PF02985
DomainAnnexin

ANXA1 USP9Y

3.26e-03141152IPR001464
DomainIMPORTIN_B_NT

TNPO2 KPNB1

3.26e-03141152PS50166
DomainIBN_N

TNPO2 KPNB1

3.74e-03151152PF03810
DomainSmall_GTP-bd_dom

RAB31 RAB22A RHOU RAB10 RAB21

3.75e-031671155IPR005225
DomainIBN_N

TNPO2 KPNB1

4.26e-03161152SM00913
DomainImportin-beta_N

TNPO2 KPNB1

4.81e-03171152IPR001494
Domain-

TXNRD2 PCYOX1L TXNRD3

4.97e-035611533.50.50.60
DomainFAD/NAD-binding_dom

TXNRD2 PCYOX1L TXNRD3

5.23e-03571153IPR023753
DomainIontro_rcpt

GRIN2C GRIN2D

5.39e-03181152IPR001320
DomainLig_chan-Glu_bd

GRIN2C GRIN2D

5.39e-03181152PF10613
DomainIono_rcpt_met

GRIN2C GRIN2D

5.39e-03181152IPR001508
DomainGlu/Gly-bd

GRIN2C GRIN2D

5.39e-03181152IPR019594
DomainLig_chan-Glu_bd

GRIN2C GRIN2D

5.39e-03181152SM00918
DomainEFTu-like_2

TUFM GSPT1

5.39e-03181152IPR004161
DomainLig_chan

GRIN2C GRIN2D

5.39e-03181152PF00060
DomainPBPe

GRIN2C GRIN2D

5.39e-03181152SM00079
DomainGTP_EFTU_D2

TUFM GSPT1

5.39e-03181152PF03144
DomainG_TR_2

TUFM GSPT1

5.39e-03181152PS51722
DomainHEAT

STK36 TNPO2 KPNB1

5.49e-03581153IPR000357
DomainTF_GTP-bd_dom

TUFM GSPT1

6.00e-03191152IPR000795
DomainPyr_redox_2

TXNRD2 TXNRD3

6.00e-03191152PF07992
DomainP-loop_NTPase

RAB31 RAB22A KIF12 ABCA10 RHOU TUFM NLRP3 GSPT1 RAB10 NLRP14 RAB21 ABCC10

6.02e-0384811512IPR027417
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_TRANSPORT_OF_CALCIUM

SLC25A4 SLC25A5 SLC25A6 GRIN2C GRIN2D

2.42e-0815885M47691
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_TRANSPORT_OF_CALCIUM

SLC25A4 SLC25A5 SLC25A6 GRIN2C GRIN2D

6.79e-0818885M47761
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TRANSPORT_OF_CALCIUM

SLC25A4 SLC25A5 SLC25A6 GRIN2C GRIN2D

9.17e-0819885M47677
PathwayREACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS

RAB31 RAB1C DENND2D RAB10 TRAPPC10 AKT1 RAB21

1.54e-0691887MM15518
PathwayREACTOME_RAB_REGULATION_OF_TRAFFICKING

RAB31 RAB1C DENND2D RAB10 TRAPPC10 AKT1 RAB21

8.73e-06118887MM15589
PathwayREACTOME_RAB_GEFS_EXCHANGE_GTP_FOR_GDP_ON_RABS

RAB31 DENND2D RAB10 TRAPPC10 AKT1 RAB21

2.04e-0590886M27779
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01006

SLC25A4 SLC25A5 SLC25A6

2.73e-0510883M47694
PathwayREACTOME_TRANSPORT_OF_NUCLEOSIDES_AND_FREE_PURINE_AND_PYRIMIDINE_BASES_ACROSS_THE_PLASMA_MEMBRANE

SLC25A4 SLC25A5 SLC25A6

4.97e-0512883M27728
PathwayREACTOME_RAB_GERANYLGERANYLATION

RAB31 RAB22A RAB1C RAB10 RAB21

5.20e-0565885MM15511
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

6.43e-0513883M47696
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

6.43e-0513883M47751
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_VGCC_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

6.43e-0513883M47703
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

SLC25A4 SLC25A5 SLC25A6

8.14e-0514883M47692
PathwayREACTOME_RAB_REGULATION_OF_TRAFFICKING

RAB31 DENND2D RAB10 TRAPPC10 AKT1 RAB21

1.13e-04122886M27872
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

1.24e-0416883M47695
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABBERANT_ATXN2_3_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

1.79e-0418883M47659
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

2.12e-0419883M47760
PathwayPID_HEDGEHOG_GLI_PATHWAY

STK36 PTCH1 CSNK1G1 AKT1

2.24e-0448884M219
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

2.48e-0420883M47688
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

2.88e-0421883M47689
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

3.32e-0422883M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

3.32e-0422883M47675
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

3.80e-0423883M47666
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

3.80e-0423883M47676
PathwayKEGG_MEDICUS_REFERENCE_TRANSPORT_OF_CALCIUM

GRIN2C GRIN2D

3.81e-045882M47667
PathwayREACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS

GRIN2C GRIN2D

3.81e-045882MM15655
PathwayPID_AR_PATHWAY

CARM1 UBA3 LATS2 AKT1

5.64e-0461884M58
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PDYN_TO_TRANSPORT_OF_CALCIUM

GRIN2C GRIN2D

5.69e-046882M47668
PathwayREACTOME_RAB_GERANYLGERANYLATION

RAB31 RAB22A RAB10 RAB21

7.18e-0465884M27771
PathwayWP_HIJACK_OF_UBIQUITINATION_BY_SARSCOV2

UBA3 NAE1

1.05e-038882M39900
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

LRRC8E STK36 SIPA1L3 HECTD4 TASP1 GRIN2D STK32C TXNRD2 PTCH1 DYSF LATS2 TXNRD3 PDZD8 AKT1 ZNF324B TTC38 ARHGAP21 ABCC10 PKN3

7.24e-0911051191935748872
Pubmed

The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.

SLC25A4 SLC25A5 SLC25A6

3.91e-083119312450408
Pubmed

DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase.

SLC25A4 SLC25A5 SLC25A6

3.91e-08311932541251
Pubmed

Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.

SLC25A4 SLC25A5 SLC25A6

3.91e-08311932829183
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

PCBP3 GEMIN2 ANXA1 POLD1 TNPO2 GART SSB RCC2 TUFM GSPT1 AKR7A2 RAB10 PCYOX1L NAE1 PATJ RAB21 HSPA2 KPNB1

7.64e-0811491191835446349
Pubmed

Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.

SLC25A4 SLC25A5 SLC25A6

1.56e-074119333396658
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

CARM1 SLC25A4 SLC25A5 SLC25A6 POLD1 GART SSB TSPYL1 RCC2 TUFM GSPT1 WDR11 SLC25A1 EXD2 NAE1 SMARCB1 HSPA2 KPNB1

2.87e-0712571191837317656
Pubmed

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.

PTCH1 LATS1 LATS2

3.89e-075119331474569
Pubmed

Neurotransmission and bipolar disorder: a systematic family-based association study.

GRIN2C GRIN2D QDPR

3.89e-075119318444252
Pubmed

Quantitative analysis of PPT1 interactome in human neuroblastoma cells.

CARM1 SLC25A4 SLC25A5 SLC25A6 SSB SLC25A1 HSPA2 KPNB1

6.83e-07210119826217791
Pubmed

The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.

SLC25A4 SLC25A5 SLC25A6

7.75e-076119310620603
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

GEMIN2 INTS7 ARHGAP10 POLD1 SIPA1L3 RAB22A TASP1 WDR55 DENND2D TSPYL1 RCC2 TUFM RAB10 WDR11 SUPT6H SLC25A1 EXD2 METTL18 PATJ

8.04e-0714971191931527615
Pubmed

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system.

SLC25A4 SLC25A5 SLC25A6

1.35e-067119321370995
Pubmed

SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation.

SLC25A4 SLC25A5 SLC25A6 RAB1C TUFM RAB10 HSPA2 KPNB1

1.80e-06239119823246001
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

SLC25A4 PCDHGB6 SLC25A5 SLC25A6 SIPA1L3 RAB22A CEP128 TUFM GSPT1 RAB10 LATS1 LATS2 SLC25A1 ALAS2 RAB21 HSPA2 ARHGAP21 KPNB1

2.05e-0614421191835575683
Pubmed

Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects.

RAB22A RAB10 RAB21

2.16e-06811939918381
Pubmed

TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

SLC25A4 SLC25A5 SLC25A6

2.16e-068119327641616
Pubmed

Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.

LATS1 ICOS LATS2

2.16e-068119332289155
Pubmed

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

CARM1 COL6A1 PCBP3 SLC25A4 SLC25A5 UGT1A7 GART RAB1C ACSF2 TUFM AKR7A2 RAB10 MRC2 NT5C2 PDZD8 AKT1 RAB21 KPNB1

2.24e-0614511191830550785
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

CARM1 RNMT SLC25A4 SLC25A5 SLC25A6 GART SSB TSPYL1 RCC2 TUFM RAB10 WDR11 EXD2 NAE1 SMARCB1 HSPA2 KPNB1

3.12e-0613351191729229926
Pubmed

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.

SLC25A4 SLC25A5 SLC25A6 TUFM POLR3B SUPT6H SMARCB1

3.39e-06183119736129980
Pubmed

Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.

SLC25A4 SLC25A6 ANXA1 POLD1 KPNB1

3.51e-0667119516226712
Pubmed

Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners.

CARM1 RNMT SLC25A5 UBA3 PTGR1 RAB21 QDPR

3.78e-06186119731540324
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

RNMT SLC25A4 SLC25A5 SLC25A6 WDR7 HECTD4 USP9Y CWC22 RCC2 TUFM RAB10 SUPT6H SLC25A1 SMARCB1 KPNB1

4.55e-0610821191538697112
Pubmed

Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.

RAB31 RAB22A RAB1C RAB10 RAB21

5.02e-0672119516923123
Pubmed

Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.

SLC25A5 SLC25A6 TUFM RAB10 ASB6 SLC25A1 NT5C2

5.70e-06198119724337577
Pubmed

RNA binding proteins co-localize with small tau inclusions in tauopathy.

PCBP3 SLC25A4 SLC25A5 WDR7 RAB1C TUFM RAB10 HSPA2

6.26e-06283119830068389
Pubmed

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.

LATS1 LATS2 AKT1

6.32e-0611119328486106
Pubmed

CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.

GRIN2C GRIN2D PATJ

6.32e-061111939647694
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

CARM1 SLC25A4 SLC25A5 SLC25A6 GART RCC2 TUFM SLC25A1 RAB21 KPNB1

6.83e-064841191031995728
Pubmed

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.

RAB22A DENND2D RAB10 RAB21

7.89e-0637119420937701
Pubmed

Mitochondrial membrane permeabilization by HIV-1 Vpr.

SLC25A4 SLC25A5 SLC25A6

8.40e-0612119316120388
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

RNMT ANXA1 TNPO2 SSB CEP128 RCC2 RAB10 SLC25A1 SMARCB1 ARHGAP21

8.75e-064981191036634849
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

COL6A1 ANXA1 RAB22A KIF12 DYSF AKR7A2 RAB10 PTGR1 SLC25A1 PATJ RAB21 QDPR HSPA2 KPNB1

1.04e-0510161191419056867
Pubmed

Ski regulates Hippo and TAZ signaling to suppress breast cancer progression.

SLC25A4 SLC25A5 SLC25A6 TUFM LATS2

1.07e-0584119525670202
Pubmed

Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer.

LATS1 LATS2

1.16e-052119225482410
Pubmed

Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells.

RAB22A RAB21

1.16e-052119210887961
Pubmed

Lats1/2-Mediated Alteration of Hippo Signaling Pathway Regulates the Fate of Bone Marrow-Derived Mesenchymal Stem Cells.

LATS1 LATS2

1.16e-052119230671453
Pubmed

Annexin A1 Regulates NLRP3 Inflammasome Activation and Modifies Lipid Release Profile in Isolated Peritoneal Macrophages.

ANXA1 NLRP3

1.16e-052119232283822
Pubmed

Akt phosphorylation of La regulates specific mRNA translation in glial progenitors.

SSB AKT1

1.16e-052119218836485
Pubmed

A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis.

LATS1 LATS2

1.16e-052119232826458
Pubmed

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.

LATS1 LATS2

1.16e-052119229730476
Pubmed

Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.

SLC25A5 SLC25A6

1.16e-052119226842067
Pubmed

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore.

SLC25A4 SLC25A5

1.16e-052119214749836
Pubmed

N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability.

LATS1 LATS2

1.16e-052119223230145
Pubmed

Role of Annexin A1 in NLRP3 Inflammasome Activation in Murine Neutrophils.

ANXA1 NLRP3

1.16e-052119233440601
Pubmed

No selenium required: reactions catalyzed by mammalian thioredoxin reductase that are independent of a selenocysteine residue.

TXNRD2 TXNRD3

1.16e-052119219366212
Pubmed

A novel membrane targeting domain mediates the endosomal or Golgi localization specificity of small GTPases Rab22 and Rab31.

RAB31 RAB22A

1.16e-052119235863437
Pubmed

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.

GRIN2C GRIN2D

1.16e-052119229317596
Pubmed

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.

LATS1 LATS2

1.16e-052119231848340
Pubmed

Expression of LATS family proteins in ovarian tumors and its significance.

LATS1 LATS2

1.16e-052119225841306
Pubmed

NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.

GRIN2C GRIN2D

1.16e-052119233766086
Pubmed

Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.

LATS1 LATS2

1.16e-052119224026096
Pubmed

A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ophthalmoplegia patients with mitochondrial DNA with multiple deletions.

SLC25A4 SLC25A6

1.16e-052119212112115
Pubmed

AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5.

NLRP3 AKT1

1.16e-052119232929041
Pubmed

Role of adenine nucleotide translocator 1 in mtDNA maintenance.

SLC25A4 SLC25A6

1.16e-052119210926541
Pubmed

Association analysis between SNPs in LATS1 and LATS2 and non-cardia gastric cancer.

LATS1 LATS2

1.16e-052119232423384
Pubmed

Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma.

LATS1 LATS2

1.16e-052119234060480
Pubmed

In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.

GRIN2C GRIN2D

1.16e-052119229651654
Pubmed

Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.

GRIN2C GRIN2D

1.16e-052119231110197
Pubmed

Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.

LATS1 LATS2

1.16e-052119217049657
Pubmed

Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance.

LATS1 LATS2

1.16e-052119231268774
Pubmed

Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.

GRIN2C GRIN2D

1.16e-052119235057644
Pubmed

The Hippo pathway regulates human megakaryocytic differentiation.

LATS1 LATS2

1.16e-052119227786336
Pubmed

NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.

GRIN2C GRIN2D

1.16e-052119231786200
Pubmed

Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction.

SLC25A4 SLC25A5

1.16e-052119227048932
Pubmed

Apoptotic and anti-proliferative effects of all-trans retinoic acid. Adenine nucleotide translocase sensitizes HeLa cells to all-trans retinoic acid.

SLC25A4 SLC25A6

1.16e-052119216556444
Pubmed

Cell type-dependent function of LATS1/2 in cancer cell growth.

LATS1 LATS2

1.16e-052119230531839
Pubmed

cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes.

SLC25A4 SLC25A6

1.16e-05211922823266
Pubmed

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.

LATS1 LATS2

1.16e-052119215746036
Pubmed

Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray.

LATS1 LATS2

1.16e-052119219799973
Pubmed

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.

LATS1 LATS2

1.16e-052119232015438
Pubmed

Expression and sequence analysis of the mouse adenine nucleotide translocase 1 and 2 genes.

SLC25A4 SLC25A5

1.16e-052119210974536
Pubmed

A novel immuno-competitive capture mass spectrometry strategy for protein-protein interaction profiling reveals that LATS kinases regulate HCV replication through NS5A phosphorylation.

LATS1 LATS2

1.16e-052119225044019
Pubmed

Nicotinamide N-methyltransferase overexpression is associated with Akt phosphorylation and indicates worse prognosis in patients with nasopharyngeal carcinoma.

AKT1 NNMT

1.16e-052119223838801
Pubmed

A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family.

SLC25A4 SLC25A6

1.16e-052119211756613
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

CARM1 SLC25A5 POLD1 GART SSB RCC2 TUFM GSPT1 SUPT6H HSPA2 KPNB1

1.28e-056381191133239621
Pubmed

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.

RNMT SLC25A5 GART AKR7A2 PTGR1 HSPA2

1.30e-05149119626370502
Pubmed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.

SLC25A4 SLC25A5 SLC25A6 ANXA1 GART SSB CWC22 RCC2 RAB10 SMARCB1 RAB21 KPNB1

1.70e-057861191229128334
Pubmed

Interactome analysis of Bag-1 isoforms reveals novel interaction partners in endoplasmic reticulum-associated degradation.

PCBP3 SLC25A4 SLC25A5 RAB1C SSB TUFM HSPA2 KPNB1

1.78e-05327119834428256
Pubmed

Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2.

SLC25A4 SLC25A5 SLC25A6 RAB10 KPNB1

1.85e-0594119536584595
Pubmed

TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.

PCBP3 SLC25A5 SLC25A6 ANXA1 GART RAB1C RCC2 TUFM FAM111B RAB10 SLC25A1 HSPA2 KPNB1

2.33e-059491191336574265
Pubmed

DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.

CARM1 WDR11 SUPT6H WDR35 SMARCB1

2.38e-0599119534161765
Pubmed

A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.

SLC25A6 TNPO2 TSPYL1 CWC22 TUFM PCYOX1L POLR3B WDR11 SUPT6H KPNB1

2.40e-055601191035241646
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

SLC25A5 SLC25A6 POLD1 SIPA1L3 GART SSB RCC2 TUFM GSPT1 RAB10 LATS1 SLC25A1 TRAPPC10 PATJ KPNB1

2.42e-0512471191527684187
Pubmed

The mitochondrial transporter family SLC25: identification, properties and physiopathology.

SLC25A4 SLC25A5 SLC25A6 SLC25A1

3.35e-0553119423266187
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

RNMT SLC25A4 SLC25A5 SLC25A6 ANXA1 GART RCC2 TUFM SLC25A1 RAB21 HSPA2 KPNB1

3.41e-058441191225963833
Pubmed

Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway.

ANGPT1 AKT1

3.47e-053119215242771
Pubmed

The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.

UBA3 NAE1

3.47e-053119214690597
Pubmed

Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits.

GRIN2C GRIN2D

3.47e-05311929718984
Pubmed

A FUS-LATS1/2 Axis Inhibits Hepatocellular Carcinoma Progression via Activating Hippo Pathway.

LATS1 LATS2

3.47e-053119230308519
Pubmed

Inhibition of microRNA-711 limits angiopoietin-1 and Akt changes, tissue damage, and motor dysfunction after contusive spinal cord injury in mice.

ANGPT1 AKT1

3.47e-053119231685802
Pubmed

Epigenetic silencing of ADAMTS18 promotes cell migration and invasion of breast cancer through AKT and NF-κB signaling.

ADAMTS18 AKT1

3.47e-053119228503860
Pubmed

Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.

LATS1 LATS2

3.47e-053119224012335
Pubmed

RRM2 Regulates Sensitivity to Sunitinib and PD-1 Blockade in Renal Cancer by Stabilizing ANXA1 and Activating the AKT Pathway.

ANXA1 AKT1

3.47e-053119234319001
Pubmed

Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems.

TXNRD2 TXNRD3

3.47e-053119211259642
Pubmed

Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53.

PTCH1 SMARCB1

3.47e-053119226363008
Pubmed

Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.

UBA3 NAE1

3.47e-053119212740388
Pubmed

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.

UBA3 NAE1

3.47e-053119212646924
Pubmed

Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway.

RAB22A AKT1

3.47e-053119235487271
InteractionCHRM4 interactions

SLC25A4 SLC25A6 GEMIN2 TNPO2 GSPT1 ABCC10

1.81e-05941176int:CHRM4
InteractionMAPT interactions

PCBP3 SLC25A4 SLC25A5 SLC25A6 WDR7 TNPO2 GART RAB22A USP9Y CEP128 TUFM GSPT1 RAB10 SLC25A1 NT5C2 AKT1 QDPR HSPA2 KPNB1

2.32e-05111911719int:MAPT
InteractionFAF1 interactions

CARM1 SLC25A5 ANXA1 GART RCC2 TUFM NLRP3 AKT1 HSPA2 KPNB1

2.54e-0533411710int:FAF1
InteractionMOB3B interactions

LATS1 LATS2 NT5C2

3.04e-05111173int:MOB3B
GeneFamilyRAB, member RAS oncogene GTPases

RAB31 RAB22A RAB1C RAB10 RAB21

9.43e-0665795388
GeneFamilyGlutamate ionotropic receptor NMDA type subunits

GRIN2C GRIN2D

3.90e-0477921201
GeneFamilyUbiquitin like modifier activating enzymes

UBA3 NAE1

8.29e-0410792100
GeneFamilyArmadillo repeat containing|Importins

TNPO2 KPNB1

2.76e-0318792596
GeneFamilyPDZ domain containing

SIPA1L3 PDZD8 PATJ ARHGAP21

4.43e-031527941220
GeneFamilyDNA polymerases

POLD1 POLI

4.49e-0323792535
GeneFamilySelenoproteins

TXNRD2 TXNRD3

5.30e-0325792890
GeneFamilyNLR family

NLRP3 NLRP14

5.30e-0325792666
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP3 NLRP14

5.30e-0325792994
ToppCelldroplet-Fat-Mat-18m-Hematologic-monocyte|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANGPT1 BBS2 DENND2D NLRP3 NT5C2 TTC38 ABCC10

4.82e-071761197867936a20f73f638055c19c8d88834aa2cc657cf
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

ARHGAP10 ANXA1 GART RAB22A CWC22 ICOS GP2

6.99e-071861197ed9b1a784f67e8a297e2a10993a6d97df60581ac
ToppCellControl-B_memory-6|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TRIM49 SCRT2 RAB31 INTS7 ACSF2 PTCH1

1.79e-06136119694f23bef50c0beb54ed39b1a4b340f7aec4e75cd
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRMT9B SLC25A4 SLC25A5 STK32B RP1 GP2

1.12e-05187119685e58a312fc325e4063a2d250666b99b8f99beb6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRMT9B SLC25A4 SLC25A5 STK32B RP1 GP2

1.12e-05187119652b5b38bef3cc06487cf42c6fb22fb33f0c7ce2b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC25A4 SLC25A6 STK32B RP1 HSPA2 GP2

1.26e-051911196f631749ef1f2270133664cf5eb4cf545a8482bd3
ToppCellChildren_(3_yrs)-Mesenchymal|Children_(3_yrs) / Lineage, Cell type, age group and donor

COL6A1 ANGPT1 ABCA10 FREM1 MRC2 NNMT

1.46e-051961196bc94909f9b2dc08a59eef1914148b69720569c8f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC25A4 SLC25A5 SLC25A6 TSPYL1 TUFM HSPA2

1.50e-05197119602cc9d39afefa5e5b6f5d93f9adc3a20050b70dd
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC25A5 SLC25A6 MCMDC2 RCC2 TUFM MRC2

1.59e-05199119615d7b2479a1426dd8f38ef70225ce07f48f320b2
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL6A1 ARHGAP10 ABCA10 FREM1 MRC2 NNMT

1.64e-052001196c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellControl-B_memory-6|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

TRIM49 SCRT2 RAB31 ACSF2 PTCH1

2.08e-0512411953e987915026f503e8d072a837b6e7a34252e5c63
ToppCellfacs-Lung-EPCAM-24m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPPC CYP26A1 KIF12 ALAS2

5.15e-0576119498271aadf026a01bf933f8279d11a0413e47d549
ToppCell390C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ANGPT1 TAF1A FAM111B MRC2 METTL18

5.52e-051521195ebce79e106bf1d84241f8dd3496ff1771f9666be
ToppCell390C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ANGPT1 TAF1A FAM111B MRC2 METTL18

5.52e-0515211954a749d1b6d35fd55a8c42d7bd04b6ff5b11ce781
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NPPC STK32A LATS2 ADAMTS18 NNMT

7.04e-051601195dd16ca90feb3ae88b6409d6c278b4765da565514
ToppCell10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-MEP|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ANGPT1 SLC25A6 FREM1 TUFM NAE1

9.11e-0516911957d39da562373865876fe16f35649b68da30a0a3a
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A1 ARHGAP10 STK32B PTCH1 NNMT

9.11e-051691195c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|Monocyte / Donor, Lineage, Cell class and subclass (all cells)

SLC25A4 TNPO2 GART USP9Y ICOS

9.37e-0517011954a19c7e3bb0f9c2601a10debe7000066789b4150
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STK32B TRIM49C FREM1 RP1 GP2

1.07e-041751195e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D3|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

HECTD4 MCMDC2 GRIN2C PCYOX1L HSPA2

1.10e-041761195bd5c85b3a4fb88ffe156599f6d224aa7664a513a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STK32B STK32A RP1 HSPA2 GP2

1.16e-0417811954df6218b20c2f076c22346d23260964cc0d73e65
ToppCellSomatosensory_Cortex_(S1)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ARHGAP10 ANXA1 USP9Y TSPAN9 DMRT3

1.19e-04179119582348bf56a4525b2f485696cab5b2ea6e96c2f91
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-MEP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ANGPT1 SSB FREM1 TUFM PDZD8

1.26e-041811195ee207ea171e2ffc22a7f850be57bb118a87e0f81
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A1 ARHGAP10 PTCH1 MRC2 ZNF324B

1.32e-0418311955377b4fbd8fdfe68933b4c0965aa9525f7f31591
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRMT9B STK32B STK32A RP1 GP2

1.36e-041841195e8238fe58f94b4f5700ab7f343fb06ea61e899a9
ToppCellCOVID-19-Fibroblasts-Adventitial_FB|COVID-19 / group, cell type (main and fine annotations)

COL6A1 PCBP3 ABCA10 FREM1 NNMT

1.39e-041851195a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCell5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A1 ANGPT1 ABCA10 FREM1 MRC2

1.43e-0418611955473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A1 NPPC ANGPT1 PTCH1 AKR7A2

1.43e-041861195360c3e9e5c3a943e68e6939b4a47821bfc75b553
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A1 RAB31 PTCH1 NNMT HSPA2

1.43e-041861195d3509a579871ba6a8c4edd6137b28f271c9dbe70
ToppCelldroplet-Spleen-SPLEEN-1m-Hematologic-erythroblast|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BBS2 CSNK1G1 ALAS2 ABCC10

1.50e-041001194f305bc37f97617007b59bf06d288dd14c3c06e42
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SIPA1L3 PTCH1 CEP128 FREM1 ADAMTS18

1.50e-041881195b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

STK32B ABCA10 STK32A RP1 GP2

1.54e-041891195f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

COL6A1 ANGPT1 PTCH1 FREM1 MRC2

1.54e-041891195dc5164591dea45b420798b94dda211be03daa70c
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RAB31 ANGPT1 ANXA1 NNMT HSPA2

1.54e-041891195d0c7549be4f77520c23dddf4f94d0fcad0081e37
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast-FB-3|PND07-28-samps / Age Group, Lineage, Cell class and subclass

COL6A1 ANGPT1 PTCH1 FREM1 MRC2

1.58e-0419011951196b8ea2c44c7c80f5ee589dd517e6a413f2077
ToppCellControl-Fibroblasts|Control / group, cell type (main and fine annotations)

COL6A1 ANGPT1 ARHGAP10 ABCA10 FREM1

1.58e-0419011953a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STK32B TSPAN9 STK32A RP1 GP2

1.62e-041911195963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

COL6A1 ARHGAP10 ABCA10 MRC2 ARHGAP21

1.65e-0419211958d56e360ebc624ca4cd7f0af4f3cc599c244f134
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A1 SLC25A4 ANXA1 MRC2 NNMT

1.70e-041931195eff718664fe0aaf89050efd9cc7b6dfb1df46666
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature4_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

COL6A1 CYP26A1 FREM1 LATS2 NT5C2

1.70e-041931195cf3cbf79ccd34ddcf06ec6194a18a7afd7f91f39
ToppCellPND07-28-samps-Mesenchymal|PND07-28-samps / Age Group, Lineage, Cell class and subclass

COL6A1 PTCH1 FREM1 MRC2 NNMT

1.74e-04194119568bcc1fe8dc8d5f23a12154fc9b41362fdef0b1d
ToppCellfacs-Heart-RA-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A1 ANXA1 STK32B RHOU MRC2

1.74e-041941195bc945450b350f597c3ff910d3a14a533d90086a8
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ENOSF1 COL6A1 SLC25A6 PTCH1 FREM1

1.78e-041951195c5d2d9f12fd893331c9de261af30607d845d4f6a
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC25A5 AKR7A2 PTGR1 QDPR HAO2

1.78e-041951195eb96439b59914954f684c4bfd9e9a6dbd3201a20
ToppCellCOVID-19-Heart-Fib_1|Heart / Disease (COVID-19 only), tissue and cell type

COL6A1 ABCA10 FREM1 MRC2 NNMT

1.78e-041951195f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCellMesenchymal_cells-Fibro/Chondro_p.|Mesenchymal_cells / Lineage and Cell class

STK32B STK32C DYSF ADAMTS18 PKN3

1.78e-041951195b95a631d54c6cf85e48e1e638703206aaaebc073
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A1 NPPC ANGPT1 PTCH1 AKR7A2

1.82e-0419611951f47916c2663bd88c1e7c19c6a7688f4c7173ad2
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A1 NPPC ANGPT1 FREM1 MRC2

1.82e-041961195617103f4a09e009fe96c28eb5e40505a4fd6dcf4
ToppCellcontrol-immature_Neutrophil|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CARM1 RAB31 WDR7 RCC2 NLRP3

1.82e-041961195e34fd3e7a5b1c22a81fd3208e6d58bdb846d51c4
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

COL6A1 TSPAN9 MRC2 PATJ NNMT

1.82e-041961195b8b9801181d7604871b48aebacb295d0a57a5eaf
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A1 NPPC ANGPT1 FREM1 MRC2

1.82e-041961195db64ab27374f82553ee577aec056141170f3656f
ToppCellCOVID-19-Fibroblasts|COVID-19 / group, cell type (main and fine annotations)

COL6A1 ANGPT1 ABCA10 MRC2 NNMT

1.86e-041971195fb847f2277609c31fffcdf49517243ce0684facf
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

COL6A1 ANGPT1 TSPAN9 MRC2 NNMT

1.91e-0419811958b9e8eaeffda40912a0163fdf39b93bc5e64751c
ToppCell10x3'2.3-week_14-16-Mesenchymal_osteo-stroma-early_osteoblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LRRC8E COL6A1 PTCH1 MRC2 NNMT

1.91e-0419811956a539d3b47bd2d4a7ad5c67cad23facffc0ac45f
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RAB31 ANXA1 DYSF RHOU NLRP3

1.91e-04198119570e62d815b2a0aa5327ff94d6f4d503176e007b9
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC25A4 SLC25A5 SLC25A6 TSPYL1 GP2

1.91e-0419811950de0c612a1f030debde28bfd6fbae3697e8b48de
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-SMC_COL-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

COL6A1 ANGPT1 TSPAN9 MRC2 NNMT

1.91e-041981195eb78b2ae6a787dbc75947e8dd5a03693285bc8be
ToppCellCOVID-19-lung-Fibroblast|lung / Disease (COVID-19 only), tissue and cell type

COL6A1 ANGPT1 ABCA10 MRC2 NNMT

1.91e-041981195df3de77216f5c5d6141ec44d01c56b942f611838
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RAB31 ANXA1 DYSF RHOU NLRP3

1.91e-04198119551c220507bb05aa6338fec494b8ecf4902437708
ToppCellMesenchymal|World / Lineage, Cell type, age group and donor

COL6A1 ANGPT1 ABCA10 FREM1 MRC2

1.95e-0419911954bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCellCOVID-19_Severe-Classical_Monocyte-cMono_3|COVID-19_Severe / Disease condition and Cell class

RAB31 SLC25A6 ANXA1 RHOU NLRP3

1.95e-041991195ffb2ef9b7006cbed0f43637af040719b9776cbd5
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAB31 ANXA1 DYSF RHOU NLRP3

1.95e-041991195571accef38f5b03a7e032495d5c6d25d27073428
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

COL6A1 ANGPT1 PTCH1 FREM1 MRC2

1.95e-041991195a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC25A6 MCMDC2 RCC2 TUFM MRC2

1.95e-0419911958e87ba32fcc1d45be73098e5baa6c9c6369b97df
ToppCellParenchymal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

STK32C PTCH1 STK35 ZNF324B TTC38

1.95e-0419911956f5ef959b51eccf1ffc2e5ddf0d83c62ca2257b2
ToppCellParenchymal-NucSeq-Stromal-Peri/Epineurial_|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

STK32C PTCH1 STK35 ZNF324B TTC38

1.95e-0419911951aa99d21bf61b86df4a966dc47634044430aa39f
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

COL6A1 ANGPT1 PTCH1 FREM1 MRC2

1.95e-04199119530d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

COL6A1 ANGPT1 POLD1 FREM1 MRC2

1.95e-041991195e1849505b92820a219c5a2c35492bdd55579fb48
ToppCellCOVID-19-kidney-PCT-S3-1|kidney / Disease (COVID-19 only), tissue and cell type

SLC25A5 SLC25A6 TSPYL1 AKR7A2 SLC25A1

1.95e-0419911953e6cfc3c0b2edce0d51db9de80e38f724e6c0cb8
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

CARM1 COL6A1 ANGPT1 POLD1 MRC2

1.95e-0419911958b86c69aaf60feff53aa782559cfece7342a23de
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC25A4 SLC25A5 SLC25A6 TUFM HSPA2

1.95e-04199119541f3f5df41a142240947d9a57a6a282cba0c7aaa
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

COL6A1 ANGPT1 PTCH1 FREM1 MRC2

2.00e-0420011959b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellBronchial-10x5prime-Stromal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL6A1 ANGPT1 ABCA10 MRC2 NNMT

2.00e-0420011955ea12e17f50fefbf5534e487af3392b2fa2d13ad
ToppCellControl_saline-Mesenchymal_fibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

COL6A1 ANGPT1 PTCH1 FREM1 MRC2

2.00e-04200119564ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC25A5 SLC25A6 MCMDC2 RCC2 TUFM

2.00e-0420011955a3b04aaad9562636aa34750d6025e0fe0f9b2ba
ToppCellSigmoid-(4)_Monocyte|Sigmoid / shred on region, Cell_type, and subtype

RAB31 STK32B DYSF RHOU NLRP3

2.00e-0420011957f3920a0434d5199c6c8f0b3064a305bb0d87b60
ToppCellSigmoid-Monocyte-Monocyte|Sigmoid / Region, Cell class and subclass

RAB31 STK32B DYSF RHOU NLRP3

2.00e-042001195010ca36970cb8894bdbca08779c0ecf56be22fc9
ToppCellTCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

SIPA1L3 SSB RCC2 WIPF2 ANKRD52

2.00e-042001195ad2a6da0b1ae7a9212a3c91e5eec4baa7481d8dc
ToppCellSigmoid-Monocyte|Sigmoid / Region, Cell class and subclass

RAB31 STK32B DYSF RHOU NLRP3

2.00e-042001195c41bd6ec0f2262fce5cadb37a400d487e6662f49
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-KLHDC8A-|Neuronal / cells hierarchy compared to all cells using T-Statistic

RAB31 ANGPT1 STK32B CYP26A1 ADAMTS18

2.00e-0420011951a04331862079092bc04b1010aa9228c0fa3d8c5
ToppCellParenchymal-10x5prime-Stromal-Fibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

COL6A1 ANGPT1 ABCA10 MRC2 NNMT

2.00e-0420011956e3d1ae0ef84d3075afa40129a41169996462672
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL6A1 ABCA10 FREM1 MRC2 NNMT

2.00e-042001195b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellTCGA-Bile_Duct-Primary_Tumor|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

SIPA1L3 SSB RCC2 WIPF2 ANKRD52

2.00e-0420011950350e5ffd36033099b7e32a1fdd790fff99790dc
ToppCellSigmoid-(4)_Monocyte-(40)_Monocyte|Sigmoid / shred on region, Cell_type, and subtype

RAB31 STK32B DYSF RHOU NLRP3

2.00e-042001195576c0a1098e6a934448705de3673ef798fcf1b26
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL6A1 ANGPT1 ABCA10 FREM1 MRC2

2.00e-0420011953dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-KLHDC8A|Neuronal / cells hierarchy compared to all cells using T-Statistic

RAB31 ANGPT1 STK32B CYP26A1 ADAMTS18

2.00e-04200119505bcde6ce8f1354ef65e4eb9cbd963a92108081c
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

COL6A1 ANGPT1 PTCH1 FREM1 MRC2

2.00e-042001195a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts|Control_saline / Treatment groups by lineage, cell group, cell type

COL6A1 ANGPT1 PTCH1 FREM1 MRC2

2.00e-042001195a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

COL6A1 ANGPT1 PTCH1 FREM1 MRC2

2.00e-042001195bd8cf33502adea320e91ca2af14e1911d88ad374
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-KLHDC8A--L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

RAB31 ANGPT1 STK32B CYP26A1 ADAMTS18

2.00e-042001195fb56d430957e73fba17db7bc0127ecf3577e0867
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL6A1 ABCA10 FREM1 MRC2 NNMT

2.00e-0420011950c25d56292b9e5fefa4521b72635449be1ffd6fe
DrugClodronate

SLC25A4 SLC25A5 SLC25A6

1.36e-0731183DB00720
DrugEAB 515

STK36 GRIN2C GRIN2D PTCH1

2.20e-07111184CID000159489
Drugdehydroabietylamine

SLC25A4 SLC25A5 SLC25A6

5.41e-0741183ctd:C000600819
Drugclosantel

SLC25A4 SLC25A5 SLC25A6

4.68e-0671183ctd:C023342
DrugddTTP

ENOSF1 SLC25A4 POLD1 AKR7A2 PTGR1 POLI

5.72e-06861186CID000065051
DrugSDZ 220-581

GRIN2C GRIN2D PTCH1

7.46e-0681183CID000128019
DrugAC1L4X2K

SLC25A4 SLC25A5 SLC25A6

1.59e-05101183CID000193824
DrugAdenosine triphosphate

SLC25A4 NAE1 NT5C2 AKT1

2.50e-05331184DB00171
Diseaseautosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (implicated_via_orthology)

SLC25A4 SLC25A5 SLC25A6

2.36e-0741163DOID:0111517 (implicated_via_orthology)
Diseasefree androgen index

RNMT ARHGAP10 UGT1A7 CYP26A1 DENND2D WDR11 ARHGAP21 MACIR ABCC10 PKN3 KPNB1

2.81e-0737411611EFO_0007005
Diseasemitochondrial metabolism disease (implicated_via_orthology)

SLC25A4 SLC25A5 SLC25A6 SLC25A1

1.08e-05351164DOID:700 (implicated_via_orthology)
Diseasecollagen alpha-1(VI) chain measurement

COL6A1 PCBP3

1.53e-0521162EFO_0801487
Diseaseras-related protein Rab-22A measurement

RAB31 RAB22A

1.52e-0451162EFO_0802991
Diseasemean arterial pressure

ENOSF1 WDR7 CYP26A1 HECTD4 BBS2 PPCDC ICOS NT5C2 ABCC10

1.62e-044991169EFO_0006340
Diseasehypertrophic cardiomyopathy (implicated_via_orthology)

SLC25A4 SLC25A5 SLC25A6

2.01e-04291163DOID:11984 (implicated_via_orthology)
Diseaseapolipoprotein B measurement

CARM1 UGT1A7 CYP26A1 ABCA10 RAB10 CSNK1G1 RP1 RAB21 PKN3 KPNB1

2.95e-0466311610EFO_0004615
Diseasebenign neoplasm (implicated_via_orthology)

LATS1 LATS2

4.22e-0481162DOID:0060072 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

SLC25A4 SLC25A5 SLC25A6 GRIN2C GRIN2D

4.74e-041631165DOID:1826 (implicated_via_orthology)
Diseasebrain ischemia (is_implicated_in)

ANGPT1 ANXA1

6.75e-04101162DOID:2316 (is_implicated_in)
Diseaseresponse to ondansetron, QT interval

COL6A1 PCBP3

8.23e-04111162EFO_0004682, EFO_0020997
Diseasekidney cancer (implicated_via_orthology)

LATS1 LATS2

8.23e-04111162DOID:263 (implicated_via_orthology)
Diseasebrain connectivity measurement

RNMT ANGPT1 CYP26A1 PTCH1 DYSF STK35 DMRT3

1.05e-034001167EFO_0005210
Diseasemyeloid white cell count

RNMT HECTD4 PPCDC TSPAN9 NLRP3 SLC25A1 CSNK1G1 POLI RP1 WIPF2 PKN3

1.19e-0393711611EFO_0007988
Diseasecreatinine measurement, glomerular filtration rate

SIPA1L3 CYP26A1 TSPAN9 FBXL20

1.19e-031171164EFO_0004518, EFO_0005208
Diseasechromosome 22q11.2 deletion syndrome, distal (implicated_via_orthology)

TXNRD2 SLC25A1

1.35e-03141162DOID:0060413 (implicated_via_orthology)
DiseaseAdenocarcinoma of lung (disorder)

ANXA1 GART LATS1 LATS2 AKT1

1.35e-032061165C0152013
Diseasefeeling emotionally hurt measurement

PTCH1 ICOS EXD2

1.41e-03561163EFO_0009599
DiseaseSynostotic Posterior Plagiocephaly

FREM1 WDR35

1.77e-03161162C1833340
DiseaseCraniosynostosis, Type 1

FREM1 WDR35

1.77e-03161162C4551902
DiseaseAcrocephaly

FREM1 WDR35

1.77e-03161162C0030044
DiseaseTrigonocephaly

FREM1 WDR35

1.77e-03161162C0265535
DiseaseScaphycephaly

FREM1 WDR35

1.77e-03161162C0265534
DiseasePolyposis, Adenomatous Intestinal

CYP26A1 AKT1

1.77e-03161162C2713442
DiseaseFamilial Intestinal Polyposis

CYP26A1 AKT1

1.77e-03161162C2713443
DiseaseSynostotic Anterior Plagiocephaly

FREM1 WDR35

1.77e-03161162C2931150
DiseaseMetopic synostosis

FREM1 WDR35

1.77e-03161162C1860819
DiseaseBrachycephaly

FREM1 WDR35

2.00e-03171162C0221356
DiseaseAdenomatous Polyposis Coli

CYP26A1 AKT1

2.00e-03171162C0032580
DiseaseIdiopathic hypogonadotropic hypogonadism

POLR3B WDR11

2.25e-03181162C0342384
DiseaseMeningioma

SMARCB1 AKT1

2.51e-03191162C0025286
Diseasecolorectal adenoma (is_marker_for)

PTCH1 TXNRD3

2.78e-03201162DOID:0050860 (is_marker_for)
Diseasecorneal hysteresis

COL6A1 ABCA10

2.78e-03201162EFO_0010066
DiseaseCraniosynostosis

FREM1 WDR35

2.78e-03201162C0010278
Diseaseskin hydration measurement

TASP1 ARHGAP21

3.06e-03211162EFO_0009586
Diseaseneutrophil count

RNMT HECTD4 PPCDC TSPAN9 NLRP3 SLC25A1 CSNK1G1 POLI AKT1 RP1 FBXL20 WIPF2 PKN3

3.09e-03138211613EFO_0004833
Diseaseskin neoplasm

RCC2 RHOU ICOS

3.13e-03741163EFO_0004198
DiseaseEsophageal Neoplasms

CYP26A1 TUFM MACIR

3.63e-03781163C0014859
DiseaseMalignant neoplasm of esophagus

CYP26A1 TUFM MACIR

3.63e-03781163C0546837
Diseaseresponse to clopidogrel, cardiovascular event measurement

DYSF FREM1

3.67e-03231162EFO_0006919, GO_1903493
Diseasemalignant astrocytoma (is_marker_for)

ANXA1 AKT1

3.67e-03231162DOID:3069 (is_marker_for)

Protein segments in the cluster

PeptideGeneStartEntry
GHIKITDFGLCKEGI

AKT1

286

P31749
TDFGLCKEGIKDGAT

AKT1

291

P31749
LLKVADAGCSVGLGK

ERC2-IT1

16

O76042
GLGDCLVKITKSDGI

SLC25A6

156

P12236
LGLGGGDCRVKIATK

AKR7A2

91

O43488
SILGVIGKEIDAACK

CEP128

826

Q6ZU80
SFCVKKGEVLGLLGH

ABCA10

1226

Q8WWZ4
CDLLGAKGKDILYIG

NT5C2

336

P49902
GLGDCLVKIYKSDGI

SLC25A5

156

P05141
KAASGLLSIGLCKGD

ACSF2

111

Q96CM8
LVNLCTKEGVLLKGG

ANGPT1

261

Q15389
CIIFLLGETVGGDKE

ASB6

216

Q9NWX5
GADLGCKDRKGYGLL

ANKRD52

196

Q8NB46
LSKGCFGLKLDRIGS

NPPC

106

P23582
VGKLLGEEKVDAILC

QDPR

71

P09417
GAKAKLCSLGFVKDI

ADAMTS18

526

Q8TE60
KLEGSKCKGQLLIFG

RCC2

96

Q9P258
KLLLIGDSGVGKTCV

RAB10

11

P61026
DCLFKLLLIGDSGVG

RAB1C

6

Q92928
KVVLLGEGCVGKTSL

RAB21

21

Q9UL25
LKVCLLGDTGVGKSS

RAB22A

6

Q9UL26
LKVCLLGDTGVGKSS

RAB31

6

Q13636
KGLRSGKLGEQCEAV

INTS7

31

Q9NVH2
AKDGGGLSTQCKVII

PCDHGB6

321

Q9Y5F9
TKGDYEKILVALCGG

ANXA1

331

P04083
GKLGDGEVFFLKECT

ARHGAP10

311

A1A4S6
IVGKVGCGKSSLLAA

ABCC10

631

Q5T3U5
LLAKGGICFIGDLAS

MCMDC2

401

Q4G0Z9
LEEKIGCLLKFSGDL

SSB

226

P05455
CLSLKEKKITEGSGG

MYCNOS

11

P40205
KFCLGEKLCADGAVG

GEMIN2

146

O14893
VKIKTLGIGAFGEVC

LATS1

706

O95835
IKTLGIGAFGEVCLA

LATS2

671

Q9NRM7
SGFLKVCGGKVLELF

HERC3

911

Q15034
GGKLCFVDLAGSEKV

KIF12

256

Q96FN5
VGKKIGCGNFGELRL

CSNK1G1

46

Q9HCP0
EVAIGFLKECGLKLT

CWC22

291

Q9HCG8
KIVLDVGCGSGILSF

CARM1

186

Q86X55
EDGIKGCGITFTLGK

ENOSF1

46

Q7L5Y1
ILKVGVGCSEDASKL

EXD2

161

Q9NVH0
LDKKGCAGGEKNVLI

HSPA2

186

P54652
SVEGGNKLVCSGLLK

PCYOX1L

241

Q8NBM8
TGEELLKLAQKCTGG

MACIR

66

Q96GV9
FKLGGLICLGHVSLK

PDZD8

721

Q8NEN9
FKIFCLDGVKGDLLI

NNMT

46

P40261
GLKKIGSLKVSCEEF

FREM1

226

Q5H8C1
VKVDKCLLGGLGLGE

GP2

236

P55259
KLDLSCNKDLGGGFE

LRRC31

286

Q6UY01
SKKACLRGGGDLVSI

MRC2

406

Q9UBG0
FAGKKVLDLGCGSGL

METTL18

186

O95568
NCGGLKKAGLLVEDT

LRRC8E

766

Q6NSJ5
TGTLERGILKKGDEC

TUFM

276

P49411
VAALCALGGFKETIK

HECTD4

1731

Q9Y4D8
VVLGKLESGSICKGQ

GSPT1

316

P15170
KIDIISGTLGKAFGC

ALAS2

381

P22557
CGSLIGKGGSKIKEI

PCBP3

141

P57721
LKGGQILCDLTKTKG

ICOS

56

Q9Y6W8
LALCDFDGDGKKELL

BBS2

166

Q9BXC9
CAIKKGLEQLLVGGS

COL6A1

131

P12109
VLELILKGCGGDLVS

DMRT3

266

Q9NQL9
LKGCGGDLVSAVEVL

DMRT3

271

Q9NQL9
LKEEILLACEGGTGT

C20orf27

116

Q9GZN8
LIGDLCTAFGKDVLK

KPNB1

821

Q14974
KRDITVLDLGCGKGG

RNMT

196

O43148
GGGLRSCVGKEFAKI

CYP26A1

436

O43174
LKGETIEGALCKDGR

FAM111B

216

Q6SJ93
GIGYKTAKCLEALGI

POLI

266

Q9UNA4
CKTVLTGKVGGLLAF

POLD1

991

P28340
CVAEEGEKKILAGKL

DYSF

1971

O75923
GCFGLFSKILDEVEK

DENND2D

161

Q9H6A0
GFLKIADFGLCKEGI

PKN3

696

Q6P5Z2
FGLLEICGVKGGETV

PTGR1

131

Q14914
IAKLKGCKVVGAVGS

PTGR1

161

Q14914
TKIAGLTGDNLCKEG

RP1

976

P56715
ALGDSGVAILCEKAK

NLRP3

866

Q96P20
GNTLGDKGIKLLCEG

NLRP3

921

Q96P20
IDGKAGLFLLGCVKN

TRIM49

371

P0CI25
LVKKIKGDGFQCSGV

SCRT2

6

Q9NQ03
CEKAFVAGLLLGKGC

TAF1A

401

Q15573
GLKALFLKGCTQLED

FBXL20

196

Q96IG2
VLKALALGAKCIFLG

HAO2

286

Q9NYQ3
KNCGKFLVVGLLIFG

PTCH1

96

Q13635
EEFLSLIGEKVCLKG

SIPA1L3

651

O60292
EKFALKLCSELGLGG

SMARCB1

291

Q12824
KLCSELGLGGEFVTT

SMARCB1

296

Q12824
LRAIGKGSFGKVCIV

STK32A

26

Q8WU08
DIKEFLCGGKGLDQL

MTRF1

406

O75570
ILLAKGGGIKLCDFG

STK36

131

Q9NRP7
LRAIGKGSFGKVCIV

STK32C

96

Q86UX6
GLGDCIIKIFKSDGL

SLC25A4

156

P12235
CVAKKLVCGDEGLGA

PPCDC

166

Q96CD2
KCVLVGDGAVGKTSL

RHOU

51

Q7L0Q8
ICQSAGLDGLAKKFG

SUPT6H

526

Q7KZ85
LLDTCKVLVIGAGGL

UBA3

66

Q8TBC4
ILKVADFGLSKVCAG

STK35

376

Q8TDR2
IVELVKDCKGLGFSI

PATJ

686

Q8NI35
LKKGVQGGEKALEIC

TSPYL1

121

Q9H0U9
GLFGVLICHLLKKKG

RELL1

71

Q8IUW5
IDGKEGLFLLGCIKN

TRIM49C

371

P0CI26
KESGILVLGAIAEGC

TNPO2

411

O14787
DCGLQILKKEGLKAF

SLC25A1

261

P53007
GKLIELLAGKAGVLD

POLR3B

941

Q9NW08
FGCEKGGANLIKELI

USP9Y

1451

O00507
CKVDLGGFAGLFDLK

GART

466

P22102
SLGGIEGCLSKLKAA

TTC38

46

Q5R3I4
KDGLIVETLTVGCKG

ZMYND11

61

Q15326
TVCGVAKGGKEILLS

TXNRD2

166

Q9NNW7
KLLLTASGDGCLGIF

WDR55

181

Q9H6Y2
SLIADIGCGTGKYLK

TRMT9B

46

Q9P272
SGGLSCAKEAAILGK

TXNRD3

166

Q86VQ6
LRAIGKGSFGKVCIV

STK32B

26

Q9NY57
GRGALLQDICKGTKL

WIPF2

36

Q8TF74
LKSLGYLCGLVSEKG

TRAPPC10

396

P48553
GKLAEGVQLLCLIDK

WDR11

1061

Q9BZH6
CGGEDGLLKVLKLET

WDR35

31

Q9P2L0
RTGLSEGDGDKLKAC

ARHGAP21

6

Q5T5U3
EEDIGKLKSCLTGFL

NAE1

451

Q13564
LEGSLVKKKGLQECF

WDR7

1336

Q9Y4E6
LLCEGQKGKLSAGRI

TASP1

146

Q9H6P5
LLLTCGFAKAGKLLV

UGT1A7

16

Q9HAW7
VTGFLGCLGAIKENK

TSPAN9

66

O75954
VDCGKGFAKGAVLLS

ZNF324B

456

Q6AW86
LKGSDIGDNGVKSLC

NLRP14

736

Q86W24
EGCKLVTIGSGKVFA

GRIN2C

741

Q14957
EGCKLVTIGSGKVFA

GRIN2D

771

O15399