Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase I general transcription initiation factor activity	UBTFL6 UBTFL1	2.75e-04	9	56	2	GO:0001181
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH2 MYH8 DYNC2H1 DNAH5	3.36e-04	118	56	4	GO:0003774
GeneOntologyMolecularFunction	RNA polymerase I core promoter sequence-specific DNA binding	UBTFL6 UBTFL1	4.18e-04	11	56	2	GO:0001164
GeneOntologyMolecularFunction	RNA polymerase I transcription regulatory region sequence-specific DNA binding	UBTFL6 UBTFL1	5.91e-04	13	56	2	GO:0001163
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DYNC2H1 DNAH5	1.15e-03	18	56	2	GO:0008569
GeneOntologyMolecularFunction	cadherin binding involved in cell-cell adhesion	EPCAM PDLIM5	1.28e-03	19	56	2	GO:0098641
GeneOntologyMolecularFunction	ATP hydrolysis activity	MYH8 DYNC2H1 GET3 MCM9 DNAH5 AQR	1.43e-03	441	56	6	GO:0016887
GeneOntologyMolecularFunction	ATP-dependent activity	MYH2 MYH8 DYNC2H1 GET3 MCM9 DNAH5 AQR	1.58e-03	614	56	7	GO:0140657
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DYNC2H1 DNAH5	2.79e-03	28	56	2	GO:0051959
GeneOntologyCellularComponent	axoneme	CFAP54 DYNC2H1 BBS7 DNAH5 BRWD1	2.30e-04	207	56	5	GO:0005930
GeneOntologyCellularComponent	ciliary plasm	CFAP54 DYNC2H1 BBS7 DNAH5 BRWD1	2.35e-04	208	56	5	GO:0097014
GeneOntologyCellularComponent	sarcomere	MYH2 MYH8 PYROXD1 PDLIM5 AHNAK2	5.36e-04	249	56	5	GO:0030017
GeneOntologyCellularComponent	myofibril	MYH2 MYH8 PYROXD1 PDLIM5 AHNAK2	8.12e-04	273	56	5	GO:0030016
GeneOntologyCellularComponent	muscle myosin complex	MYH2 MYH8	8.26e-04	16	56	2	GO:0005859
GeneOntologyCellularComponent	cell-cell junction	VANGL2 MYH2 ASH1L EPCAM PDLIM5 FRMD5 CDH13	9.72e-04	591	56	7	GO:0005911
GeneOntologyCellularComponent	contractile muscle fiber	MYH2 MYH8 PYROXD1 PDLIM5 AHNAK2	1.06e-03	290	56	5	GO:0043292
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	CFAP54 DYNC2H1 BBS7 DNAH5 BRWD1	1.58e-03	317	56	5	GO:0032838
GeneOntologyCellularComponent	myosin filament	MYH2 MYH8	2.03e-03	25	56	2	GO:0032982
Domain	FRG2	FRG2 FRG2B	2.64e-05	3	56	2	PF15315
Domain	FRG2	FRG2 FRG2B	2.64e-05	3	56	2	IPR026245
Domain	DHC_N1	DYNC2H1 DNAH5	2.44e-04	8	56	2	PF08385
Domain	Dynein_heavy_dom-1	DYNC2H1 DNAH5	2.44e-04	8	56	2	IPR013594
Domain	HMG_box	SP100 UBTFL6 UBTFL1	5.38e-04	53	56	3	PF00505
Domain	HMG_BOX_2	SP100 UBTFL6 UBTFL1	5.68e-04	54	56	3	PS50118
Domain	HMG	SP100 UBTFL6 UBTFL1	5.68e-04	54	56	3	SM00398
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH5	7.85e-04	14	56	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH5	7.85e-04	14	56	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH5	7.85e-04	14	56	2	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH5	7.85e-04	14	56	2	PF08393
Domain	MT	DYNC2H1 DNAH5	7.85e-04	14	56	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH5	7.85e-04	14	56	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DNAH5	7.85e-04	14	56	2	IPR011704
Domain	AAA_5	DYNC2H1 DNAH5	7.85e-04	14	56	2	PF07728
Domain	P-loop_NTPase	MYH2 MYH8 DYNC2H1 GET3 MCM9 ARHGAP35 DNAH5 NLRC4 AQR	8.73e-04	848	56	9	IPR027417
Domain	DHC_fam	DYNC2H1 DNAH5	9.04e-04	15	56	2	IPR026983
Domain	Myosin_N	MYH2 MYH8	9.04e-04	15	56	2	PF02736
Domain	Dynein_heavy_dom	DYNC2H1 DNAH5	9.04e-04	15	56	2	IPR004273
Domain	Myosin_N	MYH2 MYH8	9.04e-04	15	56	2	IPR004009
Domain	Dynein_heavy	DYNC2H1 DNAH5	9.04e-04	15	56	2	PF03028
Domain	HMG_box_dom	SP100 UBTFL6 UBTFL1	9.78e-04	65	56	3	IPR009071
Domain	Myosin_tail_1	MYH2 MYH8	1.31e-03	18	56	2	PF01576
Domain	Myosin_tail	MYH2 MYH8	1.31e-03	18	56	2	IPR002928
Domain	Myosin-like_IQ_dom	MYH2 MYH8	1.46e-03	19	56	2	IPR027401
Domain	-	MYH2 MYH8	1.46e-03	19	56	2	4.10.270.10
Domain	Pyr_redox_2	FOXRED2 PYROXD1	1.46e-03	19	56	2	PF07992
Domain	BROMODOMAIN_1	ASH1L BRWD1	5.50e-03	37	56	2	PS00633
Domain	Myosin_head_motor_dom	MYH2 MYH8	5.79e-03	38	56	2	IPR001609
Domain	Bromodomain	ASH1L BRWD1	5.79e-03	38	56	2	PF00439
Domain	MYOSIN_MOTOR	MYH2 MYH8	5.79e-03	38	56	2	PS51456
Domain	Myosin_head	MYH2 MYH8	5.79e-03	38	56	2	PF00063
Domain	MYSc	MYH2 MYH8	5.79e-03	38	56	2	SM00242
Domain	-	DYNC2H1 GET3 MCM9 ARHGAP35 DNAH5 NLRC4 AQR	6.67e-03	746	56	7	3.40.50.300
Domain	BROMODOMAIN_2	ASH1L BRWD1	6.72e-03	41	56	2	PS50014
Domain	BROMO	ASH1L BRWD1	7.04e-03	42	56	2	SM00297
Domain	Bromodomain	ASH1L BRWD1	7.04e-03	42	56	2	IPR001487
Domain	-	ASH1L BRWD1	7.04e-03	42	56	2	1.20.920.10
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH2 MYH8 STAC3	1.50e-06	14	57	3	27184118
Pubmed	The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome.	CSTB PRMT2	2.64e-06	2	57	2	21047530
Pubmed	Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination.	CSTB PRMT2	2.64e-06	2	57	2	18757940
Pubmed	Genomic analysis of human chromosome 10q and 4q telomeres suggests a common origin.	FRG2 FRG2B	7.91e-06	3	57	2	11829491
Pubmed	CHD1 acts via the Hmgpi pathway to regulate mouse early embryogenesis.	UBTFL6 UBTFL1	7.91e-06	3	57	2	26092847
Pubmed	FRG2, an FSHD candidate gene, is transcriptionally upregulated in differentiating primary myoblast cultures of FSHD patients.	FRG2 FRG2B	7.91e-06	3	57	2	15520407
Pubmed	Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.	MYH2 MYH8	1.58e-05	4	57	2	20357587
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	VANGL2 CCPG1 KIAA1217 GNPTAB	2.54e-05	103	57	4	10574462
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH2 MYH8	2.63e-05	5	57	2	6196357
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH2 MYH8	2.63e-05	5	57	2	3829126
Pubmed	Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.	MYH2 MYH8	2.63e-05	5	57	2	12919077
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	SRRT SP100 EEF1G PRPF3 CEBPZ KIAA1217 PPIL4 SMARCD2 AQR DNAJC2	3.37e-05	1257	57	10	36526897
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH2 MYH8	3.94e-05	6	57	2	1728586
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH2 MYH8	3.94e-05	6	57	2	10077619
Pubmed	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.	MYH2 MYH8	3.94e-05	6	57	2	10588881
Pubmed	Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development.	UBTFL6 UBTFL1	3.94e-05	6	57	2	19915186
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH2 MYH8	5.51e-05	7	57	2	35210422
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH2 MYH8	5.51e-05	7	57	2	16819597
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	VANGL2 SRRT EEF1G PRPF3 PPIL4 MRPL45 ARHGAP35 AQR ZBED5	6.21e-05	1082	57	9	38697112
Pubmed	Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.	RAG1 TRPM5	9.43e-05	9	57	2	30021144
Pubmed	Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent.	MYH2 MYH8	9.43e-05	9	57	2	10725239
Pubmed	Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice.	MYH2 MYH8	1.18e-04	10	57	2	8950513
Pubmed	A gene expression map of human chromosome 21 orthologues in the mouse.	ADAMTS1 CSTB PRMT2 BRWD1	1.34e-04	158	57	4	12466855
Pubmed	Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity.	MYH2 MYH8	1.44e-04	11	57	2	8136524
Pubmed	Human chromosome 21 gene expression atlas in the mouse.	ADAMTS1 CSTB PRMT2 BRWD1	1.51e-04	163	57	4	12466854
Pubmed	In vivo IFN-γ secretion by NK cells in response to Salmonella typhimurium requires NLRC4 inflammasomes.	RAG1 NLRC4	1.72e-04	12	57	2	24827856
Pubmed	The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity.	RAG1 NLRC4	1.72e-04	12	57	2	26384545
Pubmed	Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development.	MYH2 MYH8	1.72e-04	12	57	2	28600496
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	EEF1G PRPF3 PPIL4 SMARCD2 ARHGAP35 AQR	1.78e-04	506	57	6	30890647
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH2 MYH8	2.03e-04	13	57	2	8404542
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	DYNC2H1 DNAH5	2.03e-04	13	57	2	17884984
Pubmed	The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.	RAG1 NLRC4	2.03e-04	13	57	2	32758418
Pubmed	Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.	RAG1 NLRC4	2.03e-04	13	57	2	26572063
Pubmed	The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.	MYH2 MYH8	2.03e-04	13	57	2	8948582
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	MYH2 ADAMTS1 PRPF3 DYNC2H1 GET3 PPIL4 MRPL45 AQR	2.23e-04	1005	57	8	19615732
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DYNC2H1 DNAH5	2.37e-04	14	57	2	9373155
Pubmed	Quantitative study of the interactome of PKCζ involved in the EGF-induced tumor cell chemotaxis.	DOCK4 SRRT EEF1G PPIL4	2.41e-04	184	57	4	23402259
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	SP100 ASH1L BRWD1	2.59e-04	75	57	3	25593309
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	PRPF3 PPIL4 PRMT2 TGS1 BRWD1	2.63e-04	347	57	5	16033648
Pubmed	Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.	BMP1 MYH2	2.73e-04	15	57	2	24019467
Pubmed	A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.	RAG1 NLRC4	2.73e-04	15	57	2	27339979
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	EEF1G PRPF3 KIAA1217 PDLIM5 AHNAK2	3.11e-04	360	57	5	33111431
Pubmed	Dynamic protein-protein interaction wiring of the human spliceosome.	SRRT PRPF3 PPIL4 AQR	3.12e-04	197	57	4	22365833
Pubmed	Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.	RAG1 NLRC4	3.12e-04	16	57	2	23630357
Pubmed	Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.	MYH2 MYH8	3.53e-04	17	57	2	16124007
Pubmed	Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.	RAG1 NLRC4	3.53e-04	17	57	2	22297845
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	SP100 EEF1G KIAA1217 GET3 CSTB SMARCD2 BRWD1	4.55e-04	847	57	7	35235311
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	SRRT EEF1G PRPF3 CEBPZ CSTB ARHGAP35 AQR DNAJC2 AHNAK2	4.60e-04	1415	57	9	28515276
Pubmed	Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.	MYH8 MCM9	4.92e-04	20	57	2	21689717
Pubmed	PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential.	VANGL2 EPCAM PCDH7	5.03e-04	94	57	3	32062451
Pubmed	Circular RNA profile in liver tissue of EpCAM knockout mice.	UGP2 EPCAM	5.97e-04	22	57	2	31524221
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH2 MYH8	5.97e-04	22	57	2	24301466
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	VANGL2 CCPG1 CEBPZ DYNC2H1 BBS7 MRPL45 PCDH7 AQR DNAJC2	6.57e-04	1487	57	9	33957083
Pubmed	Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics.	EEF1G PPIL4 MRPL45	6.95e-04	105	57	3	29491746
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	BMP1 CCPG1 FOXRED2 GNPTAB CSTB PCDH7 FRMD5 CDH13	7.27e-04	1201	57	8	35696571
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SRRT PRPF3 CEBPZ SMARCD2 AQR	7.73e-04	440	57	5	34244565
Pubmed	High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.	PRPF3 AQR	7.73e-04	25	57	2	26627737
Pubmed	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.	DYNC2H1 DNAH5	7.73e-04	25	57	2	27340223
Pubmed	High-resolution comparative physical mapping of mouse chromosome 10 in the region of homology with human chromosome 21.	CSTB PRMT2	7.73e-04	25	57	2	10051316
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EEF1G PRPF3 KIAA1217 CSTB ARHGAP35 PDLIM5 AHNAK2	8.09e-04	934	57	7	33916271
Pubmed	Genetics of rheumatoid arthritis contributes to biology and drug discovery.	RAG1 PPIL4 AHNAK2	8.38e-04	112	57	3	24390342
Pubmed	The DNA sequence of human chromosome 21.	ADAMTS1 CSTB PRMT2 BRWD1	8.58e-04	258	57	4	10830953
Pubmed	Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.	MYH2 MYH8	9.71e-04	28	57	2	25179606
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	KIAA1217 PDLIM5 AHNAK2	9.75e-04	118	57	3	30979931
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ADAMTS1 GNPTAB ASH1L PRMT2 ZNF583 PDLIM5 ZBED5 BRWD1	1.12e-03	1285	57	8	35914814
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	SP100 EEF1G GET3 STAC3 UGP2	1.17e-03	483	57	5	27107014
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CEBPZ PPIL4 SMARCD2 ARHGAP35 PDLIM5 AHNAK2	1.17e-03	724	57	6	36232890
Pubmed	HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation.	MYH2 MYH8	1.27e-03	32	57	2	33732701
Pubmed	Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.	MYH2 MYH8	1.35e-03	33	57	2	32094117
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	SRRT EEF1G PRPF3 CEBPZ BBS7 GET3 AQR	1.38e-03	1024	57	7	24711643
Pubmed	Genome-wide association study of smoking behaviours among Bangladeshi adults.	SBF2 CDH13	1.43e-03	34	57	2	24665060
Pubmed	Perfect conserved linkage across the entire mouse chromosome 10 region homologous to human chromosome 21.	CSTB PRMT2	1.43e-03	34	57	2	10613844
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SRRT EEF1G PRPF3 CEBPZ PPIL4 AQR ZBED5 AHNAK2	1.56e-03	1353	57	8	29467282
Pubmed	Karyopherin Alpha 1 Regulates Satellite Cell Proliferation and Survival by Modulating Nuclear Import.	SRRT CDH13	1.60e-03	36	57	2	27434733
GeneFamily	Myosin heavy chains	MYH2 MYH8	3.14e-04	15	32	2	1098
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CFAP54 DYNC2H1 DNAH5 PCDH7 AHNAK2	4.82e-06	193	57	5	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	IPF-Epithelial\|IPF / Disease state, Lineage and Cell class	CFAP54 DYNC2H1 KIAA1217 DNAH5 EPCAM	5.19e-06	196	57	5	87d9881cfec461a5d89b688a83749b618c519485
ToppCell	Severe_COVID-19-Epithelial-transitional_Epi\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	DYNC2H1 KIAA1217 DNAH5 EPCAM AHNAK2	5.32e-06	197	57	5	5ad3cd4c77016e862041baac3076f8cc0f75c417
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Mesoderm\|6m / Sample Type, Dataset, Time_group, and Cell type.	RAG1 MYH2 MYH8 STAC3 PDLIM5	5.73e-06	200	57	5	0f6851baf0cf2a8b0c95a7a585c4407c330c5f6c
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_E\|390C / Donor, Lineage, Cell class and subclass (all cells)	FOXRED2 STAC3 FAM227B BCAS1	4.64e-05	155	57	4	98d8432739965dd1ab77c899cb6321f7f05eaa46
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RAG1 GNPTAB STAC3 CDH13	5.25e-05	160	57	4	955acb023ce4ccfac5073c9d693db87db3856187
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP54 ADAMTS1 DNAH5 AHNAK2	6.96e-05	172	57	4	0c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell	Ciliated_cells-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	CFAP54 DYNC2H1 BCAS1 DNAH5	6.96e-05	172	57	4	187ae91148d293537afc77e10da2b64302322224
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP54 ADAMTS1 DNAH5 AHNAK2	6.96e-05	172	57	4	eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KIAA1217 BCAS1 DNAH5 PCDH7	7.11e-05	173	57	4	464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Grp_(Neuron.Slc17a6.Grp)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MYH2 MYH8 TRPM5	7.96e-05	65	57	3	b7bc23af54d6d2f7afd584f4df42c24d7c49e344
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Grp_(Neuron.Slc17a6.Grp)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MYH2 MYH8 TRPM5	7.96e-05	65	57	3	3b3630253f5713c4a688c74c4ea0f98c1fe42594
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KIAA1217 BCAS1 DNAH5 PCDH7	8.66e-05	182	57	4	3f1a666fe27dd7529c114539ed5f6b8ca585c875
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell-4\|TCGA-Uvea / Sample_Type by Project: Shred V9	DOCK4 CCPG1 NLRC4 TGS1	9.03e-05	184	57	4	9c56753e5e668be888662e4713cf4ce44e6c58fb
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ADAMTS1 CNTLN PCDH7 AHNAK2	9.22e-05	185	57	4	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAG1 MYH2 BCAS1 PTCHD4	9.41e-05	186	57	4	bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCell	Cerebellum-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Htra1)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	TRPM5 FAM227B EPCAM	9.52e-05	69	57	3	54e5ede00ce2920158d1cc0ac8e718aa24a4342e
ToppCell	Cerebellum-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Htra1)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	TRPM5 FAM227B EPCAM	9.52e-05	69	57	3	c93a47ee777b560f69b705d5d597f3cb3a3f558a
ToppCell	Cerebellum-Macroglia-ASTROCYTE-Gja1-Gfap-_astrocytes_(Htra1)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	TRPM5 FAM227B EPCAM	9.52e-05	69	57	3	8946d7e433c232c56563a6c464152c0a8cdbdf92
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	ADAMTS1 PCDH7 PDLIM5 CDH13	9.61e-05	187	57	4	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	KIAA1217 PCDH7 PDLIM5 CDH13	1.00e-04	189	57	4	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	PCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CFAP54 BCAS1 DNAH5 EPCAM	1.04e-04	191	57	4	60ff989fe99d243a3d52955223680cdd1f1917a4
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	KIAA1217 EPCAM PCDH7 AHNAK2	1.06e-04	192	57	4	8899d81306770adda893b5e146df1253971754c5
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	SRRT ASH1L DNAJC2 AHNAK2	1.06e-04	192	57	4	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	KIAA1217 EPCAM PCDH7 AHNAK2	1.06e-04	192	57	4	5fda9a465c9f77c7fa1a3ea07a2b0374bbc23b2a
ToppCell	Control-Endothelial-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK4 KIAA1217 SBF2 CDH13	1.09e-04	193	57	4	aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell	Control-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK4 KIAA1217 SBF2 CDH13	1.09e-04	193	57	4	c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_NK-natural_killer_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SP100 ADAMTS1 GNPTAB PRMT2	1.11e-04	194	57	4	0abca32c3547a45cebab0bd69c1f7a0002deaa80
ToppCell	systemic_lupus_erythematosus-treated-Lymphocytic_NK-natural_killer_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	SP100 ADAMTS1 GNPTAB PRMT2	1.11e-04	194	57	4	a3a81638b55cb5fc08fe83c8b88f68d49b87e6cb
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP54 DYNC2H1 KIAA1217 DNAH5	1.13e-04	195	57	4	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	CFAP54 DYNC2H1 KIAA1217 DNAH5	1.13e-04	195	57	4	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	IPF-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	CFAP54 DYNC2H1 KIAA1217 DNAH5	1.13e-04	195	57	4	21dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP54 DYNC2H1 BCAS1 DNAH5	1.13e-04	195	57	4	9651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	DOCK4 GNPTAB CSTB AHNAK2	1.15e-04	196	57	4	bd2c2de103e28b65ea537c22f71225cb0deef1e0
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	DOCK4 GNPTAB CSTB AHNAK2	1.15e-04	196	57	4	072a4150ae521c6589b0f7cd60e975fb33715bf4
ToppCell	CD8+_Memory_T_cell-CV\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	SP100 GNPTAB CSTB PRMT2	1.20e-04	198	57	4	3d1749f5106f0912f4a74615863853949f52c73d
ToppCell	BL-critical-LOC-Epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BCAS1 DNAH5 EPCAM AHNAK2	1.20e-04	198	57	4	6218a25b94d5fa2c69880539adf9c63bfe52dcd3
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRPM5 GNPTAB BCAS1 EPCAM	1.20e-04	198	57	4	a631be84e29c277216d89ec6265bd43e87c1dc86
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS1 PCDH7 PDLIM5 CDH13	1.20e-04	198	57	4	bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCell	PSB\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DYNC2H1 EPCAM PCDH7 AHNAK2	1.20e-04	198	57	4	4e6b0d1abc55d7a0d89bd7ecf0f13dc5bed66626
ToppCell	CV\|World / Virus stimulation, Condition and Cluster	SP100 GNPTAB CSTB PRMT2	1.20e-04	198	57	4	6a28193af35abec5c029129930c2ca6febaafde2
ToppCell	BAL-Mild-Epithelial-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BCAS1 DNAH5 EPCAM PCDH7	1.22e-04	199	57	4	1ee4010d8557564e25e8ee00b914c2dfd9037838
ToppCell	Parenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS1 PCDH7 PDLIM5 CDH13	1.22e-04	199	57	4	b1753474152b82a0b811b9878c890a359e14919a
ToppCell	BAL-Mild-Epithelial\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	BCAS1 DNAH5 EPCAM PCDH7	1.22e-04	199	57	4	74087b4b5e567310fc4ac58fb267ff651a180680
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KIAA1217 PTCHD4 FRMD5 CDH13	1.24e-04	200	57	4	e79d93d55b25804f2608185168da472301b6ebca
ToppCell	Biopsy_Other_PF-Epithelial-KRT5-/KRT17+\|Biopsy_Other_PF / Sample group, Lineage and Cell type	PTCHD4 EPCAM FRMD5 AHNAK2	1.24e-04	200	57	4	077e6b9340686de9d0f11b035a8954e1f6a1b790
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KIAA1217 PTCHD4 FRMD5 CDH13	1.24e-04	200	57	4	107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-Mesoderm\|3m / Sample Type, Dataset, Time_group, and Cell type.	RAG1 MYH2 MYH8 STAC3	1.24e-04	200	57	4	538ae964db58c4acafe93f735b3e03fc08fdaac6
ToppCell	Nasal_Brush-Epithelial\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	CCPG1 UGP2 BCAS1 EPCAM	1.24e-04	200	57	4	7911073119ee47a37b68b73fc54f063e902a5067
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS1 PCDH7 PDLIM5 CDH13	1.24e-04	200	57	4	a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB--L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KIAA1217 PTCHD4 FRMD5 CDH13	1.24e-04	200	57	4	5ec469267747dce3601c1d8ad01af89fa5b29acc
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	KIAA1217 PTCHD4 FRMD5 CDH13	1.24e-04	200	57	4	320d5a3a1e7da2fa8f1a164e29e180ec8ac9889c
Disease	myopathy (implicated_via_orthology)	MYH2 MYH8 PDLIM5	8.44e-05	48	52	3	DOID:423 (implicated_via_orthology)
Disease	chemotherapy-induced alopecia, methylcobalamin deficiency type cblE	DNAH5 CDH13	8.47e-05	8	52	2	EFO_0005400, MONDO_0009354
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH2 MYH8	1.36e-04	10	52	2	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH2 MYH8	1.36e-04	10	52	2	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH2 MYH8	1.36e-04	10	52	2	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH2 MYH8	1.36e-04	10	52	2	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH2 MYH8	1.36e-04	10	52	2	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH2 MYH8	1.36e-04	10	52	2	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH2 MYH8	1.36e-04	10	52	2	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH2 MYH8	1.36e-04	10	52	2	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH2 MYH8	1.99e-04	12	52	2	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH2 MYH8	1.99e-04	12	52	2	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH2 MYH8	2.35e-04	13	52	2	DOID:397 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	MYH2 MYH8 PDLIM5	2.71e-04	71	52	3	DOID:0050700 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH2 MYH8	3.15e-04	15	52	2	DOID:0050646 (implicated_via_orthology)
Disease	thyroid volume	FAM227B DNAH5	3.60e-04	16	52	2	EFO_0004865
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH2 MYH8 PDLIM5	3.85e-04	80	52	3	DOID:12930 (implicated_via_orthology)
Disease	neuropsychological test	VANGL2 SP100 KIAA1217 CDH13	4.06e-04	197	52	4	EFO_0003926
Disease	Ciliopathies	DYNC2H1 BBS7 DNAH5	9.75e-04	110	52	3	C4277690
Disease	Strabismus	KIAA1217 DNAH5	1.20e-03	29	52	2	HP_0000486
Disease	Astigmatism	DOCK4 DNAH5 CDH13	1.54e-03	129	52	3	HP_0000483
Disease	HOMA-IR	KIAA1217 MCM9	1.55e-03	33	52	2	EFO_0004501
Disease	testosterone measurement	DOCK4 MYH2 SBF2 MCM9 BCAS1 FRMD5 NLRC4 BRWD1	1.65e-03	1275	52	8	EFO_0004908

Protein segments in the cluster

Peptide	Gene	Start	Entry
FFKLSEEFVDPKSHK	VANGL2	496	Q9ULK5
STSFEPHFKKKKVSA	FAM200B	46	P0CF97
TKKPHEVKQDFEKFL	FAM227B	456	Q96M60
FEKDVKGESLFHSKK	EPCAM	216	P16422
DLFIDKFKFKGTNVK	BBS7	676	Q8IWZ6
VKEFFSKPKYNHILK	PRMT2	281	P55345
FDHFPKKLTPKKDFS	ASH1L	2811	Q9NR48
QFKATFFPKGFKDKT	CFAP54	171	Q96N23
PKDYFHDKNAKKPTF	CNTLN	931	Q9NXG0
LEFKCKHSKSFKENP	GSG1	261	Q2KHT4
ENKKFPVFKAVSFKS	CSTB	31	P04080
IFKKKPDHFPFFFKH	AQR	111	O60306
KNDHSPKFTKKEFQA	CDH13	356	P55290
VSKKGFKAHFFSDKD	BMP1	691	P13497
PHQKDDINKKAFDKF	DNAJC2	511	Q99543
LKAHPKFSKKFHDNE	RAG1	81	P15918
FVKKKKESFNAIPTF	ADAMTS1	841	Q9UHI8
SFFEAEKVPRIKHKK	PPIL4	76	Q8WUA2
TAQRFKPKYKFFHKS	NLRC4	431	Q9NPP4
KEKRFPKFKRHDVNS	GNPTAB	671	Q3T906
APKHTSDKAFFDLKT	SBF2	1806	Q86WG5
FQKPKVVKGKAEAHF	MYH8	566	P13535
DFFTPQQHDKSKKPK	PCDH7	921	O60245
FQKPKVVKGKAEAHF	MYH2	566	Q9UKX2
QTFFSKKDKPLCKKH	PDLIM5	576	Q96HC4
DSKGKFHVTPKFFLE	FOXRED2	291	Q8IWF2
EKKPFKEKGKTAFSH	FRG2B	36	Q96QU4
EKKPFKEKGKTAFSH	FRG2	36	Q64ET8
FQFFPKHSEKLERKI	FRMD5	161	Q7Z6J6
EKKKNSVDPDFLKSF	DYNC2H1	2841	Q8NCM8
KPVHFKEFRKNTNSK	CCPG1	596	Q9ULG6
PFHKGTKDKENEFKS	DOCK4	1421	Q8N1I0
FHKNASFFKKTKILS	BRWD1	1806	Q9NSI6
DAFDQKFSKVPTKVK	GET3	81	O43681
FDAKKFAETQPKKDT	EEF1G	216	P26641
SKPKDSSFFDKFFKL	BCAS1	186	O75363
TPKVKKDKQNIFEFF	CEBPZ	156	Q03701
KKEHKKSFIFTDGDN	DNAH5	2056	Q8TE73
TFKFHDKGKFEKIAQ	PRPF3	326	O43395
AKFTFKQKSKLIHSF	MCM9	921	Q9NXL9
NFKIKDFPEKAKDIF	MRPL45	131	Q9BRJ2
FLTFFPPSKKHHKKK	PTCHD4	806	Q6ZW05
ATDDQFESPKKKFKF	KIAA1217	1561	Q5T5P2
LKKFPKENHEVFKYV	ARHGAP35	1361	Q9NRY4
DPSKQKRKFSSFFKS	SMARCD2	241	Q92925
KFKGPEFVRKHIFNK	SRRT	721	Q9BXP5
VHDLKTPKFAFSTEK	AHNAK2	486	Q8IVF2
DSKFKKLHFKVPKVS	AHNAK2	4696	Q8IVF2
KLHFKVPKVSFSSTK	AHNAK2	4701	Q8IVF2
PKAHVDEFKSVSKFK	UGP2	311	Q16851
SLPKTDQFFKKVKFH	UBTFL6	211	P0CB48
DQFFKKVKFHGEPQK	UBTFL6	216	P0CB48
PKTDRFFKKVKFHGE	UBTFL1	206	P0CB47
KVAEKQFKEKFPSKH	TRPM5	276	Q9NZQ8
KKKSFTFPRDHKSVT	PYROXD1	276	Q8WU10
HKKKNPDASVKFSEF	SP100	701	P23497
KDKDISFFKQHLDSP	ZBED5	161	Q49AG3
KNKHIFFTKESEKPF	TGS1	491	Q96RS0
FFTKESEKPFFKKSK	TGS1	496	Q96RS0
NDKPHKFKDHFFKKP	STAC3	86	Q96MF2
KFKDHFFKKPKFCDV	STAC3	91	Q96MF2
FDIQQSFPTKEKAHK	ZNF583	171	Q96ND8