Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessdouble-strand break repair

ESCO2 TEX15 POLQ PHF10 APLF

5.64e-05324275GO:0006302
GeneOntologyBiologicalProcesspronephros development

AHI1 CEP290

7.38e-0510272GO:0048793
GeneOntologyBiologicalProcessregulation of DNA metabolic process

ESCO2 TEX15 POLQ PHF10 APLF YLPM1

7.38e-05564276GO:0051052
GeneOntologyBiologicalProcessmotile cilium assembly

FSIP2 AHI1 CFAP43

2.04e-0488273GO:0044458
GeneOntologyBiologicalProcessotic vesicle development

AHI1 CEP290

2.22e-0417272GO:0071599
GeneOntologyCellularComponentphotoreceptor distal connecting cilium

AHI1 CEP290

3.36e-057272GO:0120206
GeneOntologyCellularComponentMKS complex

AHI1 CEP290

1.45e-0414272GO:0036038
GeneOntologyCellularComponentsite of double-strand break

ESCO2 POLQ APLF

2.94e-04101273GO:0035861
GeneOntologyCellularComponentsite of DNA damage

ESCO2 POLQ APLF

7.18e-04137273GO:0090734
GeneOntologyCellularComponentphotoreceptor connecting cilium

AHI1 CEP290

1.75e-0348272GO:0032391
DomainDEAD

POLQ DDX6

4.96e-0373272PF00270
DomainDEAD/DEAH_box_helicase_dom

POLQ DDX6

4.96e-0373272IPR011545
DomainHelicase_C

POLQ DDX6

1.04e-02107272PF00271
DomainHELICc

POLQ DDX6

1.04e-02107272SM00490
DomainHelicase_C

POLQ DDX6

1.06e-02108272IPR001650
DomainHELICASE_CTER

POLQ DDX6

1.08e-02109272PS51194
DomainHELICASE_ATP_BIND_1

POLQ DDX6

1.08e-02109272PS51192
DomainDEXDc

POLQ DDX6

1.08e-02109272SM00487
DomainHelicase_ATP-bd

POLQ DDX6

1.10e-02110272IPR014001
Domain-

DNM1 POLQ DDX6 YLPM1

2.13e-027462743.40.50.300
Pubmed

Investigating embryonic expression patterns and evolution of AHI1 and CEP290 genes, implicated in Joubert syndrome.

AHI1 CEP290

5.80e-07227223028714
Pubmed

Genetic screening of LCA in Belgium: predominance of CEP290 and identification of potential modifier alleles in AHI1 of CEP290-related phenotypes.

AHI1 CEP290

5.80e-07227220683928
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

EIF3H MAGED1 PHF10 PRRC2C PPP1R12A DDX6 YLPM1

1.02e-0672427736232890
Pubmed

Prospective Evaluation of Kidney Disease in Joubert Syndrome.

AHI1 CEP290

1.74e-06327229146704
Pubmed

High NPHP1 and NPHP6 mutation rate in patients with Joubert syndrome and nephronophthisis: potential epistatic effect of NPHP6 and AHI1 mutations in patients with NPHP1 mutations.

AHI1 CEP290

1.74e-06327217409309
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

FSIP2 EIF3H PRRC2C PPP1R12A YLPM1

1.27e-0539927535987950
Pubmed

Defective Wnt-dependent cerebellar midline fusion in a mouse model of Joubert syndrome.

AHI1 CEP290

2.08e-05927221623382
Pubmed

Global landscape of HIV-human protein complexes.

EIF3H MAGED1 NFAT5 PPP1R12A DDX6

2.44e-0545727522190034
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

LRRC8C MAGED1 NFAT5 PHF10 PRRC2C

2.93e-0547527531040226
Pubmed

SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium.

AHI1 CEP290

3.18e-051127229899041
Pubmed

mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.

FAM184B ANKRD12 SPTB

6.04e-059827334943047
Pubmed

Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.

AHI1 CEP290

8.81e-051827221068128
Pubmed

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

EIF3H MAGED1 PRRC2C DDX6

9.83e-0531527426777405
Pubmed

Identification of novel ARF binding proteins by two-hybrid screening.

ANKRD12 ZNF235

1.21e-042127216582619
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

ESCO2 FAM184B ANKRD12 AHI1 NFAT5 PPP1R12A

1.53e-04108427611544199
Pubmed

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.

CFAP43 DNM1

2.17e-042827218839057
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

EIF3H PRRC2C PPP1R12A

2.26e-0415327326365490
Pubmed

Joubert Syndrome

AHI1 CEP290

3.21e-043427220301500
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

EIF3H NFAT5 PPP1R12A DDX6 YLPM1

3.55e-0480927532129710
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

EIF3H PRRC2C DDX6 YLPM1

4.23e-0446227431138677
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

EIF3H MAGED1 PRRC2C CEP290

4.48e-0446927427634302
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

EIF3H MAGED1 PHF10 PRRC2C PPP1R12A DDX6

4.68e-04133527629229926
Pubmed

A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum.

POLQ NFAT5

5.38e-044427232492419
Pubmed

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

EIF3H PRRC2C DDX6

6.79e-0422327320020773
Pubmed

Congenital Hepatic Fibrosis Overview ─ RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

AHI1 CEP290

7.51e-045227220301743
CytobandEnsembl 112 genes in cytogenetic band chr10q25

CFAP43 AFAP1L2

2.71e-03131272chr10q25
CytobandEnsembl 112 genes in cytogenetic band chr12q21

PPP1R12A CEP290

3.13e-03141272chr12q21
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

AFAP1L2 DNM1 SPTB

1.44e-03206203682
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

PPP1R12A YLPM1

1.68e-02181202694
GeneFamilyAnkyrin repeat domain containing

ANKRD12 PPP1R12A

2.89e-02242202403
CoexpressionIKEDA_MIR133_TARGETS_UP

ANKRD12 NFAT5 PPP1R12A

1.26e-0544273M2377
CoexpressionIKEDA_MIR133_TARGETS_UP

ANKRD12 NFAT5 PPP1R12A

1.34e-0545273MM929
CoexpressionRAO_BOUND_BY_SALL4_ISOFORM_A

POLQ NFAT5 PHF10 APLF

4.47e-05194274M2517
CoexpressionGSE3691_IFN_PRODUCING_KILLER_DC_VS_CONVENTIONAL_DC_SPLEEN_UP

ANKRD12 USF3 EIF3H MAGED1

5.03e-05200274M6363
CoexpressionRAO_BOUND_BY_SALL4_ISOFORM_A

POLQ NFAT5 PHF10 APLF

6.08e-05210274MM958
CoexpressionAGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_DN

AHI1 PHF10 PPP1R12A CEP290

9.71e-05237274M8897
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_top-relative-expression-ranked_1000

ESCO2 LRRN3 AHI1 DNM1 NFAT5 PHF10 YLPM1

4.28e-05819267gudmap_developingKidney_e15.5_Peripheral blastema_1000
ToppCellAdult-Immune-mast_cell|Adult / Lineage, Cell type, age group and donor

ESCO2 AFAP1L2 TMC2 SPTB

2.60e-0616127444f5c0256b3ce264a6c7b62740f32dcd45ee052d
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANKRD12 EIF3H PRRC2C DDX6

5.33e-061932744e78ddc96d8e403a21c4a303b1f26512d2ac91e8
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

ANKRD12 AHI1 PRRC2C CEP290

5.78e-061972740fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCellCerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Acta2Rgs5.Rgs5_(Mural.Acta2Rgs5.Rgs5)|Cerebellum / BrainAtlas - Mouse McCarroll V32

CFAP43 ZNF235 APLF

7.17e-051342731fa13185a4dfb4563473184c0c4f449011d88631
ToppCellCerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Acta2Rgs5.Rgs5_(Mural.Acta2Rgs5.Rgs5)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

CFAP43 ZNF235 APLF

7.17e-051342731ab99a22d0d7657f62f8ea7d96bb24e88de54fd4
ToppCellCerebellum-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3|Cerebellum / BrainAtlas - Mouse McCarroll V32

CFAP43 ZNF235 APLF

7.17e-051342738a3acf32cabc37b49d6488d43cdaae7cec79d119
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pvalb|Cerebellum / BrainAtlas - Mouse McCarroll V32

ANKRD12 MAGED1 PRRC2C

9.82e-051492736e9ca280a599d96f8956ef26f2a46b9484de5488
ToppCellfacs-Trachea-nan-3m-Myeloid-lymphocyte_of_B_lineage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 FAM184B POLQ

1.15e-041572730fecc14959c4c9efc19d5c06475a890e0a30f148
ToppCellAdult-Immune-mast_cell-D231|Adult / Lineage, Cell type, age group and donor

ESCO2 TMC2 SPTB

1.15e-041572734c63bb91f8708644e6ce2500072a4eeb8e1079dd
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ESCO2 AFAP1L2 POLQ

1.28e-04163273466c8129852a5b16cd9fcc6b79e799abc21bb21a
ToppCellsystemic_lupus_erythematosus-flare-Hematopoietic-Progen-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

FAM184B LRRN3 DDX6

1.38e-04167273b89ebd4906f52b1fe6b6540ec9339284e7caddd2
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)|368C / Donor, Lineage, Cell class and subclass (all cells)

LRRN3 TMC2 ZNF235

1.40e-041682731bc6a1915d48f547385ed4f44e118bcc8a4a7b6c
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|368C / Donor, Lineage, Cell class and subclass (all cells)

LRRN3 TMC2 ZNF235

1.40e-0416827369f534de0f9a293047bea03cb1b78551087a8df5
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

LRRN3 TMC2 ZNF235

1.40e-0416827383b4f817d95daa15ae60668e789f97d8a3b2e6dd
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

LRRN3 TMC2 ZNF235

1.40e-04168273c66a61d3ec711796313a2c6d2dc39aedbfc20afd
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 TEX15 POLQ

1.43e-04169273121768fc51fc3441ec725346a1bbe29e21d05971
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 TEX15 POLQ

1.43e-041692730bc8ef341ce307b19018d4ac8de0a4d04254209d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AHI1 AFAP1L2 NFAT5

1.45e-04170273928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_G2M|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ESCO2 POLQ APLF

1.50e-041722731171e754fd503a0c1152162fcc12a115088a08c7
ToppCell368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell|368C / Donor, Lineage, Cell class and subclass (all cells)

ESCO2 LRRN3 POLQ

1.58e-0417527374800a10f5ff25d5414fbccb0668f92ff077d1cc
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 TEX15 POLQ

1.63e-04177273f925a15d2162d166a5b60edac3517c6b2d6cfbea
ToppCellHSPCs-Erythroblasts|World / Lineage and Cell class

ESCO2 PHF10 SPTB

1.74e-04181273ce26f1accc8f69b7bc4b929073e975c887566c6a
ToppCelldroplet-Limb_Muscle-nan-3m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B LRRN3 AFAP1L2

1.80e-041832732cf36ad89584eb9f8b04de52a1b511b7f3527884
ToppCelldroplet-Limb_Muscle-nan-3m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B LRRN3 AFAP1L2

1.80e-0418327398fee6838acfaee5e2e449ba088764ec06b8bc57
ToppCellfacs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B AFAP1L2 PPP1R12A

1.80e-041832738d45dff06a199b1369576657f7f9dc0249c5f841
ToppCellfacs-Heart-LA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B AFAP1L2 PPP1R12A

1.80e-04183273421265fa15d5a028cb567bb0904e670473ef102b
ToppCellwk_15-18-Hematologic-Meg-ery-Cycling_definitive_erythroblast|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ESCO2 POLQ SPTB

1.83e-04184273238eba615b4e04967d44ac7858a6673bdd7f67e9
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B AFAP1L2 POLQ

1.83e-041842739f8cd5ab5af6c35a1be25d70a125b9a3f4dd667a
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-interneuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD12 DNM1 SPTB

1.89e-04186273a1ab273b01971d6a892912560d387685dd657179
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

ANKRD12 NFAT5 PPP1R12A

1.89e-0418627303db813598b67b1e08f759758a1c2023396921fa
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ESCO2 AFAP1L2 POLQ

1.92e-04187273057569c9437219ecc396aa6e673b1178a2273837
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD12 DNM1 SPTB

1.92e-04187273ef3c85c01bc3da408ae288b6e3096ad888a12e63
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 AHI1 CEP290

1.98e-041892733ade3fa9369e85304b20d7233b581f18ad5ecc89
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 AHI1 CEP290

1.98e-0418927316dfc37d8d390ed7f927bc844c47c9c5a89a0928
ToppCelldroplet-Marrow-nan-3m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

POLQ SPTB CEP290

1.98e-041892738a38baee58a27c2fa3f4bd131ab9f15723ed9295
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD12 DNM1 SPTB

1.98e-041892733d838da870623a6a278ddc8e6cedca85d9877e50
ToppCellGlobus_pallidus-Neuronal|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ANKRD12 DNM1 SPTB

2.01e-04190273416de85d8841dac883faa6f5339b2fb461a09e82
ToppCelldroplet-Limb_Muscle-nan-18m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B LRRN3 SPTB

2.01e-04190273e2481bd5166fde2cdc0c3824894f2bccb8294fdd
ToppCelltumor_Lung-T/NK_cells-Exhausted_Tfh|tumor_Lung / Location, Cell class and cell subclass

LRRN3 ANKRD12 AHI1

2.04e-041912733e259eba83f8159d1a1a96b98d0e867fe547c5e7
ToppCellfacs-Pancreas-Endocrine-3m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHI1 MAGED1 DDX6

2.04e-04191273b3de0393d6510543533cd851e47a0f95739a0e4e
ToppCelldroplet-Marrow-BM_(NON-STC)-30m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ESCO2 PHF10 CEP290

2.04e-0419127324ebc8d4a9fc3782510162e04fe586f7cb371eed
ToppCellwk_20-22-Hematologic_Lymphocytic-T_&_ILC-Cycling_T|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ESCO2 LRRN3 POLQ

2.11e-0419327381e6240cffb094b2aa3684fd0889b6497f47c4f0
ToppCellCOVID-19_Mild|World / Disease condition and Cell class

ANKRD12 PRRC2C DDX6

2.11e-041932737256a5a491536c525b31ae96d47ab5c6303cb73a
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANKRD12 PRRC2C PPP1R12A

2.14e-04194273e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCellCOVID-19-T_cells-Cycling_NK/T_cells|COVID-19 / group, cell type (main and fine annotations)

ESCO2 POLQ SPTB

2.17e-04195273764ed100c28d9bc93ee5ecabc5291c8f184d78da
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANKRD12 AHI1 PRRC2C

2.17e-04195273ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCellCOVID_non-vent-Lymphocytic-T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

LRRN3 ANKRD12 DDX6

2.17e-041952734bdedd924564a260841a9153604026b57487c83d
ToppCelltumor_Lung-T/NK_cells-Exhausted_Tfh|T/NK_cells / Location, Cell class and cell subclass

LRRN3 ANKRD12 AHI1

2.20e-041962735a0b5aeff7e535781ea2a4c85799bb468afcb6f8
ToppCellprimary_visual_cortex-Neuronal|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

AHI1 MAGED1 DNM1

2.20e-041962738efc2b3a95f57c31be203ac781b2098d4909297f
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ESCO2 TEX15 POLQ

2.24e-0419727376b61e60a757e58b465569538e632d6d9953e89a
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ANKRD12 PRRC2C DDX6

2.24e-04197273ef2d1f56acd0be43e69bba7f73f6909ba87f1cb3
ToppCellCOVID-19_Mild|World / Disease group, lineage and cell class

ANKRD12 PRRC2C DDX6

2.24e-041972735c33454b10023decd2f5ccda9229b6512659711e
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)

ANKRD12 PRRC2C DDX6

2.27e-0419827344417089b62056269cac38d3134ff209c05b7007
ToppCellPBMC-Mild|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ANKRD12 PRRC2C DDX6

2.27e-0419827328ef3fc4c17dcb765537b75917f7db78baa522db
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6|World / Primary Cells by Cluster

LRRN3 ANKRD12 CEP290

2.31e-041992731b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal|World / Primary Cells by Cluster

LRRN3 ANKRD12 CEP290

2.31e-041992734bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANKRD12 PRRC2C DDX6

2.31e-04199273f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

ANKRD12 PRRC2C CEP290

2.31e-0419927361b1ed2db71b96157b92b7535d1955a4033098da
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

ANKRD12 PRRC2C CEP290

2.31e-0419927353ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell(09)_Interm._secr.>cil.-(2)_GFP_FOXI1|(09)_Interm._secr.>cil. / shred by cell type by condition

ANKRD12 PRRC2C CEP290

2.31e-04199273fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell(03)_KRT6B+-(2)_GFP_FOXI1|(03)_KRT6B+ / shred by cell type by condition

ANKRD12 PRRC2C CEP290

2.31e-04199273c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCellmild-CD4+_Tcm|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANKRD12 PRRC2C DDX6

2.31e-0419927306c8a0e39f7a33736548f04a5e2263334c8541cf
ToppCellmLN-T_cell-Tfh|T_cell / Region, Cell class and subclass

FAM184B ANKRD12 DDX6

2.31e-04199273a234f14ff46a0dc2f916a80e1e7af7d793006050
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

ANKRD12 PRRC2C ZNF706

2.31e-04199273a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANKRD12 PRRC2C DDX6

2.34e-0420027312f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellsevere-CD4+_T_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANKRD12 EIF3H PRRC2C

2.34e-04200273f74bdabadca8ad6dae1b6e6812c66325aac50db0
ToppCellCOVID-19|World / Disease, condition lineage and cell class

ANKRD12 PRRC2C DDX6

2.34e-042002737dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-7|TCGA-Brain / Sample_Type by Project: Shred V9

TMC2 POLQ

1.50e-0395272bc445d5029e7831833c35537a12956cb1c793953
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMC2 SPTB

1.75e-031032723f4e4600c8a9af3534479ca19905c3d31c4c55bb
ToppCellEntopeduncular-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Cldn11_(Cldn11)|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ZNF235 POLQ

1.86e-031062725e01b9dd76a2f5904100de603310e6c0a553fbda
ToppCellEntopeduncular-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Cldn11_(Cldn11)-|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ZNF235 POLQ

1.86e-03106272be9de0f664395079fef9f3bbdffa651ea6f58be2
ToppCellmild_COVID-19-RBC|World / disease group, cell group and cell class (v2)

POLQ SPTB

2.26e-0311727285210be67ddc31903764b7fa6d7029d9656753d3
ToppCellmild_COVID-19-RBC|mild_COVID-19 / disease group, cell group and cell class (v2)

POLQ SPTB

2.37e-03120272cccea760901558ec18d5cbb71c7971c5a51da571
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-5|TCGA-Stomach / Sample_Type by Project: Shred V9

CFAP43 DNM1

2.41e-03121272392700c5032b83d4d4e191fea9bcd170e4567b9d
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LRRC8C AFAP1L2

2.77e-03130272fc68a648161dd314d9ee6612fd039cb12171b8c6
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LRRC8C AFAP1L2

2.77e-031302720f9d3e6297f48ae14d24ac997d8d3a94f337d4d4
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRRN3 POLQ

2.86e-03132272f1b448efccbf87caa86d1a794c43a230a4b0758e
ToppCellBronchial-NucSeq-Stromal-Pericyte-Muscle_pericyte_systemic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AFAP1L2 SPTB

2.94e-03134272bffd6ce8998368d4f486b64c220eab3a44ba147b
ToppCellLPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TEX15 PHF10

3.03e-03136272a2063abe2d7c3277bfbe1514c8c66363cf04b248
ToppCellLPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TEX15 PHF10

3.07e-031372728e2fa2ef8becace96a68bb85c002329110902fbb
ToppCell(08)_Brush+PNEC-(2)_GFP_FOXI1|(08)_Brush+PNEC / shred by cell type by condition

ANKRD12 PRRC2C

3.12e-03138272817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCellCOVID-19-Mast_cells-Dendritic_cells|COVID-19 / group, cell type (main and fine annotations)

ESCO2 SPTB

3.25e-031412720fc06c2325249aa4ae65c0ace1ec3f953372f2e4
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-2|TCGA-Colorectal / Sample_Type by Project: Shred V9

CFAP43 SPTB

3.30e-03142272959af19add016f21c814c28604d0177b88ebed12
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

LRRN3 ZNF235

3.30e-03142272199a0a1024b6cc446f5ca1f277846a2bdb227a9f
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|COVID-19 / Disease (COVID-19 only), tissue and cell type

FAM184B SPTB

3.39e-03144272f92e03dd784e31a9e5dbd4f4c3a6517ea19210cf
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1|Entopeduncular / BrainAtlas - Mouse McCarroll V32

FSIP2 PPP1R12A

3.53e-0314727227e97a7b1dc296f52990b5810a52ab0a7ef2b9e6
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_3|E16.5-samps / Age Group, Lineage, Cell class and subclass

LRRN3 PRRC2C

3.62e-03149272651494e84be03dc7b061ebdfa91756a1c507b9b4
ToppCellE16.5-samps|World / Age Group, Lineage, Cell class and subclass

ESCO2 MAGED1

3.62e-03149272e94d075f68c1c70c89fab50b1b765b5dda650d09
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Serpinf1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FAM184B TEX15

3.62e-031492725293c50b3fb41b1edaf9a97354899bd13770078c
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

APLF SPTB

3.67e-03150272c2c51a3230c978e2fdb1b3ae14193d4014431b25
ToppCell356C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

AHI1 AFAP1L2

3.67e-03150272580ed7733857402345f43ca2623f72cdd1edf22c
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

ANKRD12 PRRC2C

3.72e-03151272999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

AFAP1L2 NFAT5

3.72e-0315127210da94037225a71844281ddcb395072250a78094
ToppCellDividing_Macrophages-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

ESCO2 POLQ

3.77e-03152272e39cfc346b35235546b303e7d73e4d9d7120a5fb
ToppCell368C-Fibroblasts-Fibroblast-H|368C / Donor, Lineage, Cell class and subclass (all cells)

MAGED1 APLF

3.77e-031522729f3682da00fd627e80aa820ecc6f5fed23b9738a
ToppCell3'_v3-blood-Lymphocytic_T_CD8-Trm_gut_CD8|blood / Manually curated celltypes from each tissue

LRRN3 ZNF235

3.77e-031522721fea735321da6db6d2cd3f83d2f7fac72d44904d
ToppCell368C-Fibroblasts-Fibroblast-H-|368C / Donor, Lineage, Cell class and subclass (all cells)

MAGED1 APLF

3.77e-03152272dbfb4d4de36ef9f5c7da1950baa915b12788685e
ToppCellCOVID-19_Mild-PLT_0|World / Disease Group and Platelet Clusters

USF3 CFAP43

3.77e-03152272d49f7c0681500fc4d93818d47e8e8afb726c23d9
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-astrocyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM184B TMC2

3.86e-031542725ed64bbf603290e6dc34f81d145982690b89dd0d
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|Heart / Disease (COVID-19 only), tissue and cell type

FAM184B SPTB

3.91e-03155272d7e26696fd9c0a759524f331243db43059b33ed9
DrugDeltaline [6836-11-9]; Down 200; 7.8uM; PC3; HT_HG-U133A

AHI1 NFAT5 PPP1R12A DDX6 CEP290

2.67e-061902754306_DN
DrugMidodrine hydrochloride [3092-17-9]; Down 200; 13.8uM; HL60; HG-U133A

ANKRD12 DNM1 NFAT5 PPP1R12A YLPM1

3.11e-061962751403_DN
DrugEtifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT_HG-U133A

NFAT5 PRRC2C PPP1R12A CEP290

5.51e-051782743998_DN
Drughafnium hydroxide

ESCO2 PPP1R12A

6.06e-0510272CID000082817
DrugSulfaphenazole [526-08-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A

ANKRD12 NFAT5 PRRC2C PPP1R12A

6.40e-051852741673_DN
DrugNeostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT_HG-U133A

NFAT5 PRRC2C PPP1R12A CEP290

6.81e-051882746735_DN
DrugFlupentixol dihydrochloride cis-(Z) [2413-38-9]; Down 200; 7.8uM; HL60; HT_HG-U133A

NFAT5 PRRC2C PPP1R12A CEP290

6.95e-051892741288_DN
DrugAmpyrone [83-07-8]; Down 200; 19.6uM; PC3; HT_HG-U133A

TEX15 NFAT5 PRRC2C SPTB

7.10e-051902744507_DN
DrugThioguanosine [85-31-4]; Down 200; 12.6uM; HL60; HT_HG-U133A

AHI1 PRRC2C CEP290 YLPM1

7.69e-051942741264_DN
DrugLumicolchicine gamma [6901-14-0]; Down 200; 10uM; MCF7; HT_HG-U133A

ANKRD12 AHI1 NFAT5 CEP290

7.85e-051952743254_DN
DrugCefepime hydrochloride [123171-59-5]; Down 200; 7.4uM; HL60; HT_HG-U133A

AHI1 TEX15 PRRC2C CEP290

7.85e-051952746159_DN
DrugRilmenidine hemifumarate [54187-04-1]; Up 200; 8.4uM; PC3; HT_HG-U133A

LRRN3 ZNF235 SPTB CEP290

8.32e-051982745107_UP
DrugHexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; MCF7; HT_HG-U133A

ANKRD12 DNM1 CEP290 YLPM1

8.49e-051992746244_DN
DiseaseFamilial aplasia of the vermis

AHI1 CEP290

1.52e-0420272cv:C0431399
Diseasecongenital left-sided heart lesions

CFAP43 AFAP1L2

8.86e-0448272EFO_0005938
Diseaseobsolete_red blood cell distribution width

ANKRD12 AHI1 APLF PRRC2C SPTB YLPM1

1.16e-031347276EFO_0005192
DiseaseCiliopathies

AHI1 CEP290

4.55e-03110272C4277690
Diseaseplatelet component distribution width

AHI1 AFAP1L2 DNM1 PRRC2C

4.67e-03755274EFO_0007984
DiseasePolydactyly

AHI1 CEP290

5.13e-03117272C0152427

Protein segments in the cluster

PeptideGeneStartEntry
TQTQQQMNQLKNTNT

DDX6

36

P26196
QMNQLKNTNTINNGT

DDX6

41

P26196
NMMQQQKLTNISKQQ

CFAP43

1626

Q8NDM7
NTYMRNTSKQQQQKH

EIF3H

261

O15372
NTEMNNIKTNAQRNK

APLF

281

Q8IW19
SQQSKLKQSNMLTAQ

AHI1

1011

Q8N157
YMNKVTINKQQNAES

AFAP1L2

56

Q8N4X5
TRNKANTMANQSKQI

ANKRD12

1736

Q6UB98
QTQNVNQAKMATSQA

MAGED1

196

Q9Y5V3
FANAQQRSNQMNKKK

DNM1

496

Q05193
QRSNQMNKKKTSGNQ

DNM1

501

Q05193
QKAKLQAQVSQMQQA

FAM184B

601

Q9ULE4
TNKNQKMAAALQSNI

FSIP2

1466

Q5CZC0
QAKQIQNSVFQTMVQ

NFAT5

996

O94916
SQMQQQNTQKVEASK

PHF10

181

Q8WUB8
AQQEKFSKTMIQLQN

CEP290

1281

O15078
KSLVQQNSMNSFQKE

POLQ

1356

O75417
NFMKQTNIQKNTNTR

ESCO2

351

Q56NI9
QNNLSSVTNINVKKM

LRRN3

101

Q9H3W5
NSQSSKMNSIVYQKQ

PRRC2C

2696

Q9Y520
MQKKRNLVQGTQTSQ

USF3

1521

Q68DE3
QTVQLFMKKNQTLQN

SPTB

1511

P11277
LADTSSNQQKNFKMQ

YLPM1

866

P49750
MARGQQKIQSQQKNA

ZNF706

1

Q9Y5V0
QQNDKNSKVLMQNAA

TEX15

2616

Q9BXT5
VVKRSQQFSKMQNVS

TMC2

451

Q8TDI7
TQNYQRSCKQTQMKN

ZNF235

191

Q14590
QSQVANKTMRKRNTN

nan

46

Q8N9L7
KDNRKNNMNRSNTIQ

LRRC8C

186

Q8TDW0
ANMDNNQSQKTFKNK

PPP1R12A

306

O14974