Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transcription coregulator activity	SUPT20HL1 KMT2D SMARCA2 CCAR1 NCOA1 SIN3A MIDEAS MED12	7.10e-05	562	50	8	GO:0003712
GeneOntologyMolecularFunction	molecular adaptor activity	SUPT20HL1 KMT2D CTCF GAB4 SMARCA2 SNAP23 CCAR1 NCOA1 SIN3A MIDEAS MED12	4.33e-04	1356	50	11	GO:0060090
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	CCAR1 NCOA1 MED12	4.80e-04	61	50	3	GO:0030374
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	SUPT20HL1 KMT2D GAB4 SMARCA2 SNAP23 CCAR1 NCOA1 SIN3A MIDEAS MED12	5.14e-04	1160	50	10	GO:0030674
GeneOntologyMolecularFunction	transcription coactivator activity	KMT2D SMARCA2 CCAR1 NCOA1 MED12	9.43e-04	303	50	5	GO:0003713
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	TET2 SUPT20HL1 BMP6 KMT2D SETX EAPP CTCF SMARCA2 CHCHD2 NCOA1 ZFHX3 IRF5 MGA MED12 PYGO1 CRX	1.25e-07	1390	51	16	GO:0045944
GeneOntologyBiologicalProcess	termination of RNA polymerase II transcription, poly(A)-coupled	SETX SCAF4	1.80e-05	3	51	2	GO:0030846
GeneOntologyBiologicalProcess	regulation of termination of RNA polymerase II transcription, poly(A)-coupled	SETX SCAF4	1.80e-05	3	51	2	GO:2000804
GeneOntologyBiologicalProcess	regulation of termination of RNA polymerase II transcription	SETX SCAF4	3.59e-05	4	51	2	GO:1904594
GeneOntologyBiologicalProcess	regulation of termination of DNA-templated transcription	SETX SCAF4	8.93e-05	6	51	2	GO:0031554
HumanPheno	Phimosis	KMT2D CTCF SIN3A	1.72e-05	12	23	3	HP:0001741
Domain	CCDC74_C	CCDC74B CCDC74A	7.02e-06	2	50	2	PF14917
Domain	CCDC74	CCDC74B CCDC74A	7.02e-06	2	50	2	IPR033226
Domain	CCDC74_C	CCDC74B CCDC74A	7.02e-06	2	50	2	IPR029422
Domain	ZnF_U1	CIZ1 ZFHX3	2.72e-03	29	50	2	SM00451
Domain	Znf_U1	CIZ1 ZFHX3	2.72e-03	29	50	2	IPR003604
Domain	Znf_FYVE_PHD	KMT2D BSN PYGO1	7.15e-03	147	50	3	IPR011011
Pathway	WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY	KMT2D CTCF SMARCA2 NCOA1 SIN3A MED12	1.40e-04	301	38	6	MM15983
Pathway	WP_CIRCADIAN_RHYTHM_GENES	SETX NGFR ZFHX3 SIN3A CRX	1.92e-04	201	38	5	M39605
Pubmed	Human transcription factor protein interaction networks.	TET2 KMT2D CTCF SMARCA2 CCAR1 NCOA1 ZFHX3 IRF5 R3HDM2 SIN3A MGA MIDEAS GARRE1 SCAF4 PYGO1 FTSJ3	1.55e-10	1429	52	16	35140242
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	KMT2D SMARCA2 CCAR1 NCOA1 ZFHX3 SIN3A MIDEAS MED12	1.34e-09	220	52	8	35785414
Pubmed	Interaction network of human early embryonic transcription factors.	TET2 KMT2D SMARCA2 NCOA1 ZFHX3 MGA MIDEAS MED12 CRX	2.46e-09	351	52	9	38297188
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	TET2 KMT2D SMARCA2 NCOA1 SIN3A MGA MIDEAS MED12	6.29e-09	268	52	8	33640491
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	TET2 CIZ1 NCOA1 R3HDM2 MIDEAS GARRE1	1.09e-07	152	52	6	38360978
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2D CIZ1 NAA30 SIN3A MGA MIDEAS MED12 SCAF4	1.50e-06	549	52	8	38280479
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SETX CTCF AAK1 CIZ1 SMARCA2 SNAP23 CCAR1 ZFHX3 TANC1 INTS8 MED12 SCAF4	1.61e-06	1497	52	12	31527615
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TET2 KMT2D DYNC2H1 CIZ1 SMARCA2 NCOA1 MGA	2.09e-06	398	52	7	35016035
Pubmed	Transcriptional repression by the insulator protein CTCF involves histone deacetylases.	CTCF SIN3A	2.19e-06	2	52	2	10734189
Pubmed	Patterns of CTCF and ZFHX3 Mutation and Associated Outcomes in Endometrial Cancer.	CTCF ZFHX3	2.19e-06	2	52	2	26330387
Pubmed	Characterization of four novel CAG repeat-containing cDNAs.	KMT2D R3HDM2	2.19e-06	2	52	2	8595911
Pubmed	Somatic mutations in KMT2D and TET2 associated with worse prognosis in Epstein-Barr virus-associated T or natural killer-cell lymphoproliferative disorders.	TET2 KMT2D	2.19e-06	2	52	2	31311407
Pubmed	CCDC74A/B are K-fiber crosslinkers required for chromosomal alignment.	CCDC74B CCDC74A	2.19e-06	2	52	2	31521166
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	TET2 KMT2D SETX SMARCA2 CCAR1 NCOA1 SIN3A MIDEAS MED12 SCAF4	4.66e-06	1103	52	10	34189442
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CTCF CIZ1 SMARCA2 ZFHX3 TANC1 SIN3A RAPGEF2 MGA GARRE1 FTSJ3	5.16e-06	1116	52	10	31753913
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	KMT2D SIN3A MGA MIDEAS MED12	5.21e-06	167	52	5	20362541
Pubmed	A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.	CTCF SMARCA2 TANC1 SEC31A MIDEAS MED12 SCAF4	6.40e-06	472	52	7	38943005
Pubmed	Utilization of Biomarkers in Lupus Nephritis.	IRF5 ITGAM	6.57e-06	3	52	2	31733719
Pubmed	TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing.	TET2 CTCF	6.57e-06	3	52	2	26711177
Pubmed	The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.	TET2 KMT2D	6.57e-06	3	52	2	26551667
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MICALL1 TET2 SETX AAK1 BSN PLEKHG5 GARRE1	1.34e-05	529	52	7	14621295
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	KMT2D SETX CTCF CIZ1 CCAR1 SIN3A MGA MIDEAS SCAF4 FTSJ3	1.87e-05	1294	52	10	30804502
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	CTCF CIZ1 SMARCA2 CCAR1 NCOA1 ZFHX3 MGA CRX	2.50e-05	808	52	8	20412781
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SETX AAK1 SMARCA2 CCAR1 TANC1 SEC31A MGA MIDEAS MED12 FTSJ3	2.74e-05	1353	52	10	29467282
Pubmed	Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes.	SMARCA2 SIN3A	3.28e-05	6	52	2	21566081
Pubmed	Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.	SMARCA2 SIN3A	3.28e-05	6	52	2	15314177
Pubmed	Activation of ATP-binding cassette transporter A1 transcription by chromatin remodeling complex.	SMARCA2 NCOA1	3.28e-05	6	52	2	15774904
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	KMT2D CTCF SMARCA2 MGA MED12 FTSJ3	3.33e-05	410	52	6	26949251
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MICALL1 TET2 SETX AAK1 TANC1 RAPGEF2 CSPP1 GARRE1	3.92e-05	861	52	8	36931259
Pubmed	Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression.	SMARCA2 SIN3A	4.58e-05	7	52	2	17074803
Pubmed	A census of human transcription factors: function, expression and evolution.	KMT2D CTCF NCOA1 ZFHX3 IRF5 MGA MIDEAS CRX	5.70e-05	908	52	8	19274049
Pubmed	Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression.	IRF5 SIN3A	6.10e-05	8	52	2	20935208
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SETX CTCF CIZ1 CCAR1 MGA MIDEAS SCAF4 FTSJ3	8.04e-05	954	52	8	36373674
Pubmed	A human MAP kinase interactome.	SETX SEC31A RAPGEF2 MGA MIDEAS PYGO1	8.53e-05	486	52	6	20936779
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	LRRC24 CTCF AAK1 CCAR1 SEC31A RAPGEF2 BSN MGA	8.58e-05	963	52	8	28671696
Pubmed	Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing.	SMARCA2 SIN3A	9.79e-05	10	52	2	15696166
Pubmed	TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.	TET2 SIN3A	9.79e-05	10	52	2	21490601
Pubmed	Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.	SMARCA2 SIN3A	9.79e-05	10	52	2	11238380
Pubmed	Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.	IRF5 ITGAM	1.20e-04	11	52	2	18204446
Pubmed	Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.	SMARCA2 SIN3A MED12	1.35e-04	66	52	3	23275444
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	TET2 WBP1L ZFHX3 TANC1 SEC31A SCAF4	1.45e-04	536	52	6	15840001
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MICALL1 KMT2D AAK1 SMARCA2 CCAR1 SIN3A SCAF4	1.47e-04	774	52	7	15302935
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	TET2 WBP1L ZFHX3 TANC1 SEC31A SCAF4	1.48e-04	538	52	6	10512203
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	KMT2D SIN3A MIDEAS INTS8 MED12	1.57e-04	341	52	5	32971831
Pubmed	Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.	IRF5 ITGAM	1.69e-04	13	52	2	18204098
Pubmed	Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.	KMT2D NCOA1	1.97e-04	14	52	2	12482968
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	KMT2D SMARCA2 NCOA1	2.22e-04	78	52	3	28611094
Pubmed	Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control.	SMARCA2 SIN3A	2.27e-04	15	52	2	17255939
Pubmed	Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.	IRF5 ITGAM	2.27e-04	15	52	2	20881011
Pubmed	Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus.	IRF5 ITGAM	2.60e-04	16	52	2	20848568
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	KMT2D SMARCA2 MIDEAS	2.66e-04	83	52	3	28794006
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	MICALL1 AAK1 SNAP23 TANC1 MGA GARRE1 FTSJ3	2.67e-04	853	52	7	28718761
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	CASR MGA SCAF4 PYGO1	2.89e-04	212	52	4	19521566
Pubmed	Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.	SMARCA2 NCOA1	2.94e-04	17	52	2	19183483
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	CTCF CIZ1 SIN3A MIDEAS FTSJ3	3.05e-04	394	52	5	27248496
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MICALL1 EAPP DYNC2H1 CIZ1 SNAP23 CHCHD2 TANC1 CSPP1 FTSJ3	3.25e-04	1487	52	9	33957083
Pubmed	mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.	SMARCA2 SIN3A	3.30e-04	18	52	2	14559996
Pubmed	Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.	TET2 CCAR1 MGA FTSJ3	3.44e-04	222	52	4	35941108
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	KMT2D DYNC2H1 SMARCA2 NCOA1 BSN CSPP1	3.70e-04	638	52	6	31182584
Pubmed	Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.	SIN3A ITGAM PYGO1	3.96e-04	95	52	3	24029230
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TET2 KMT2D ZFHX3 MGA MED12	4.00e-04	418	52	5	34709266
Pubmed	PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.	CCAR1 SEC31A	4.09e-04	20	52	2	32079660
Pubmed	ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.	SMARCA2 SIN3A	4.52e-04	21	52	2	12453419
Pubmed	Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.	IRF5 ITGAM	4.52e-04	21	52	2	21408207
Pubmed	The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.	NCOA1 MED12	4.97e-04	22	52	2	11867769
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	SETX SMARCA2 CCAR1 FTSJ3	5.38e-04	250	52	4	33536335
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	KMT2D MED12	5.44e-04	23	52	2	9225980
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	KMT2D CTCF CCAR1 SCAF4	5.46e-04	251	52	4	31076518
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	SETX SIN3A MGA MIDEAS MED12	5.76e-04	453	52	5	29656893
Pubmed	Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.	MICALL1 CIZ1 MIDEAS	5.76e-04	108	52	3	19531213
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	R3HDM2 MGA FTSJ3	5.92e-04	109	52	3	33554859
Pubmed	GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.	IRF5 ITGAM	5.93e-04	24	52	2	24871463
Pubmed	Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.	SMARCA2 SIN3A	5.93e-04	24	52	2	18454139
Pubmed	Foxn4 is a temporal identity factor conferring mid/late-early retinal competence and involved in retinal synaptogenesis.	BSN CRX	6.96e-04	26	52	2	32071204
Pubmed	Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis.	CTCF SIN3A	6.96e-04	26	52	2	26244796
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MICALL1 AAK1 CCAR1 NAA30 SEC31A MGA	7.19e-04	724	52	6	36232890
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	TET2 SETX MGA MED12	7.38e-04	272	52	4	31010829
Pubmed	A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.	IRF5 ITGAM	7.51e-04	27	52	2	23740937
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DYNC2H1 PLEKHH2 MGA MED12 SCAF4	8.42e-04	493	52	5	15368895
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SETX CTCF AAK1 SNAP23 CCAR1 MIDEAS SCAF4 FTSJ3	9.18e-04	1371	52	8	36244648
Pubmed	A genetic linkage map of the mouse: current applications and future prospects.	MICALL1 BMP6	9.29e-04	30	52	2	8211130
Pubmed	Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.	KMT2D MGA	9.92e-04	31	52	2	15960975
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	CTCF SMARCA2	9.92e-04	31	52	2	23602572
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	SETX SNAP23 ZFHX3 SEC31A RAPGEF2 MGA	1.04e-03	777	52	6	35844135
Pubmed	Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.	NGFR ITGAM	1.06e-03	32	52	2	26758845
Pubmed	Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.	C8B ITGAM	1.06e-03	32	52	2	18842294
Pubmed	GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.	TANC1 SIN3A	1.12e-03	33	52	2	21658281
Pubmed	DHHC protein family targets different subsets of glioma stem cells in specific niches.	NCOA1 SIN3A	1.12e-03	33	52	2	30658672
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MICALL1 KMT2D LRRC24 IRF5 TANC1 PLEKHG5 MED12	1.23e-03	1105	52	7	35748872
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	AAK1 CHCHD2 SIN3A MGA FTSJ3	1.34e-03	547	52	5	37267103
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	SIN3A MGA MIDEAS	1.38e-03	146	52	3	23892456
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	ZFHX3 SIN3A	1.49e-03	38	52	2	33283408
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	NGFR PLEKHG5	1.49e-03	38	52	2	11756498
Pubmed	Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.	IRF5 ITGAM	1.49e-03	38	52	2	23273568
Interaction	TEAD1 interactions	KMT2D CTCF SMARCA2 NCOA1 ZFHX3 SIN3A MGA MIDEAS CRX	5.34e-10	176	51	9	int:TEAD1
Interaction	SP7 interactions	TET2 KMT2D SMARCA2 CCAR1 NCOA1 SIN3A MGA MIDEAS SCAF4 PYGO1	3.89e-09	304	51	10	int:SP7
Interaction	CRX interactions	TET2 KMT2D SMARCA2 NCOA1 ZFHX3 MGA MIDEAS MED12 CRX	1.34e-08	254	51	9	int:CRX
Interaction	EGR2 interactions	TET2 KMT2D SMARCA2 NCOA1 ZFHX3 MGA MIDEAS	2.37e-07	171	51	7	int:EGR2
Interaction	LHX2 interactions	KMT2D CTCF SMARCA2 ZFHX3 MGA PYGO1 FTSJ3	3.75e-07	183	51	7	int:LHX2
Interaction	HNF1B interactions	TET2 KMT2D SMARCA2 ZFHX3 MGA MIDEAS CRX	4.83e-07	190	51	7	int:HNF1B
Interaction	MYB interactions	KMT2D CTCF SMARCA2 ZFHX3 SIN3A MGA	1.04e-06	133	51	6	int:MYB
Interaction	EYA4 interactions	TET2 AAK1 CIZ1 NCOA1 R3HDM2 MIDEAS GARRE1	2.50e-06	243	51	7	int:EYA4
Interaction	NHLH1 interactions	KMT2D CTCF SMARCA2 MGA FTSJ3	2.84e-06	88	51	5	int:NHLH1
Interaction	NUP43 interactions	KMT2D SETX CTCF CIZ1 ZFHX3 RAPGEF2 MGA MIDEAS MED12 FTSJ3	3.11e-06	625	51	10	int:NUP43
Interaction	SNRNP40 interactions	SETX CTCF CIZ1 CCAR1 ZFHX3 MGA MIDEAS MED12 SCAF4 FTSJ3	3.68e-06	637	51	10	int:SNRNP40
Interaction	TLE3 interactions	TET2 KMT2D CCAR1 NCOA1 ZFHX3 MIDEAS SCAF4 CRX	4.31e-06	376	51	8	int:TLE3
Interaction	GATA3 interactions	KMT2D CTCF SMARCA2 CCAR1 MIDEAS SCAF4	7.50e-06	187	51	6	int:GATA3
Interaction	TBR1 interactions	TET2 KMT2D SMARCA2 ZFHX3 MIDEAS	9.70e-06	113	51	5	int:TBR1
Interaction	NFIC interactions	TET2 KMT2D SMARCA2 MGA MIDEAS CRX	1.45e-05	210	51	6	int:NFIC
Interaction	GCM1 interactions	TET2 KMT2D SMARCA2 MIDEAS	2.63e-05	68	51	4	int:GCM1
Interaction	ALL1 interactions	SMARCA2 SIN3A	3.76e-05	4	51	2	int:ALL1
Interaction	SS18L2 interactions	DYNC2H1 CIZ1 SMARCA2 CHCHD2	4.08e-05	76	51	4	int:SS18L2
Interaction	NR4A2 interactions	SMARCA2 NCOA1 SIN3A	4.28e-05	27	51	3	int:NR4A2
Interaction	SOX7 interactions	TET2 KMT2D SMARCA2 NCOA1	5.50e-05	82	51	4	int:SOX7
Interaction	LHX4 interactions	KMT2D SMARCA2 CHCHD2 MGA PYGO1	6.17e-05	166	51	5	int:LHX4
Interaction	YWHAH interactions	MICALL1 TET2 SETX AAK1 NCOA1 R3HDM2 TANC1 RAPGEF2 CSPP1 PLEKHG5 GARRE1	7.85e-05	1102	51	11	int:YWHAH
Interaction	TLX1 interactions	KMT2D SMARCA2 ZFHX3 MIDEAS PYGO1	7.93e-05	175	51	5	int:TLX1
Interaction	HDAC1 interactions	TET2 KMT2D CTCF SMARCA2 ZFHX3 IRF5 SIN3A MGA MIDEAS MED12 FTSJ3	8.25e-05	1108	51	11	int:HDAC1
Interaction	TLX3 interactions	TET2 KMT2D SMARCA2 ZFHX3 MIDEAS CRX	8.98e-05	291	51	6	int:TLX3
Interaction	KLF9 interactions	CTCF SIN3A MGA FTSJ3	9.00e-05	93	51	4	int:KLF9
Interaction	PACSIN2 interactions	MICALL1 SMARCA2 IRF5 C11orf52 FTSJ3	1.03e-04	185	51	5	int:PACSIN2
Interaction	SOX9 interactions	KMT2D SMARCA2 MIDEAS MED12	1.06e-04	97	51	4	int:SOX9
Interaction	NFIA interactions	KMT2D SMARCA2 MIDEAS CRX FTSJ3	1.11e-04	188	51	5	int:NFIA
Interaction	MYOD1 interactions	KMT2D SMARCA2 NCOA1 MGA MIDEAS	1.29e-04	194	51	5	int:MYOD1
Interaction	LHX1 interactions	KMT2D CTCF SMARCA2 MGA	1.34e-04	103	51	4	int:LHX1
Interaction	NIPBL interactions	TET2 SETX MGA MED12 CRX	1.45e-04	199	51	5	int:NIPBL
Interaction	FEV interactions	KMT2D CTCF ZFHX3 MGA MIDEAS	1.59e-04	203	51	5	int:FEV
Interaction	AR interactions	TET2 KMT2D SMARCA2 CCAR1 NCOA1 ZFHX3 SIN3A MGA MIDEAS MED12	1.62e-04	992	51	10	int:AR
Interaction	EN1 interactions	KMT2D CTCF MGA MIDEAS	1.72e-04	110	51	4	int:EN1
Interaction	PAX8 interactions	TET2 KMT2D SMARCA2 MIDEAS	1.78e-04	111	51	4	int:PAX8
Interaction	TBXT interactions	KMT2D SMARCA2 CCAR1 MIDEAS	2.11e-04	116	51	4	int:TBXT
Interaction	SP140L interactions	CHCHD2 RAPGEF2	2.23e-04	9	51	2	int:SP140L
Interaction	CEBPA interactions	TET2 KMT2D SETX SMARCA2 CCAR1 NCOA1 SIN3A MIDEAS MED12 SCAF4 FTSJ3	2.31e-04	1245	51	11	int:CEBPA
Interaction	ETS1 interactions	KMT2D SMARCA2 NCOA1 MGA	2.48e-04	121	51	4	int:ETS1
Interaction	NFIX interactions	KMT2D SMARCA2 ZFHX3 MGA MIDEAS	2.67e-04	227	51	5	int:NFIX
Interaction	KLF3 interactions	KMT2D SMARCA2 ZFHX3 MGA MIDEAS	2.73e-04	228	51	5	int:KLF3
Interaction	PAX7 interactions	KMT2D SMARCA2 ZFHX3 MIDEAS	2.73e-04	124	51	4	int:PAX7
Interaction	PAGR1 interactions	KMT2D NCOA1 CRX	2.92e-04	51	51	3	int:PAGR1
Interaction	NCOR1 interactions	SMARCA2 NCOA1 IRF5 SIN3A SEC31A MGA	2.98e-04	363	51	6	int:NCOR1
Interaction	PAX6 interactions	KMT2D CTCF SMARCA2 ZFHX3 MGA MIDEAS	3.11e-04	366	51	6	int:PAX6
Interaction	PAX9 interactions	KMT2D SMARCA2 ZFHX3 MIDEAS	3.27e-04	130	51	4	int:PAX9
Interaction	LHX8 interactions	KMT2D SMARCA2 PYGO1	3.27e-04	53	51	3	int:LHX8
Interaction	YAP1 interactions	KMT2D CIZ1 SMARCA2 NAA30 SIN3A RAPGEF2 MGA MIDEAS MED12 SCAF4	3.58e-04	1095	51	10	int:YAP1
Interaction	H3C1 interactions	KMT2D CTCF DYNC2H1 SMARCA2 ZFHX3 SIN3A MGA MIDEAS FTSJ3	3.84e-04	901	51	9	int:H3C1
Interaction	MAU2 interactions	TET2 SETX MGA MED12	3.88e-04	136	51	4	int:MAU2
Interaction	NTF4 interactions	NGFR CRX	4.08e-04	12	51	2	int:NTF4
Interaction	ELF5 interactions	KMT2D SMARCA2 SIN3A MIDEAS	5.20e-04	147	51	4	int:ELF5
Interaction	KDM1A interactions	TET2 CCDC74B KMT2D CCDC74A SMARCA2 ZFHX3 SIN3A MGA MED12	5.27e-04	941	51	9	int:KDM1A
Interaction	TFAP4 interactions	CTCF SIN3A MIDEAS CRX	6.05e-04	153	51	4	int:TFAP4
Interaction	HNF4A interactions	KMT2D SMARCA2 NCOA1 MGA MIDEAS	6.42e-04	275	51	5	int:HNF4A
Interaction	ARID1A interactions	CTCF SMARCA2 NCOA1 SIN3A CRX	6.52e-04	276	51	5	int:ARID1A
Interaction	CREBBP interactions	KMT2D SMARCA2 NCOA1 IRF5 SIN3A MGA CRX	7.36e-04	599	51	7	int:CREBBP
Interaction	RBBP5 interactions	KMT2D SMARCA2 SIN3A MGA CRX	7.78e-04	287	51	5	int:RBBP5
Interaction	FAM184A interactions	SMARCA2 CSPP1 GARRE1	8.05e-04	72	51	3	int:FAM184A
Interaction	KLF15 interactions	KMT2D CTCF NCOA1 MGA FTSJ3	8.15e-04	290	51	5	int:KLF15
Interaction	EED interactions	SETX CTCF SMARCA2 CCAR1 TANC1 SIN3A SEC31A MGA INTS8 SCAF4 FTSJ3	8.18e-04	1445	51	11	int:EED
Interaction	CNTROB interactions	SETX SMARCA2 BSN GARRE1	8.21e-04	166	51	4	int:CNTROB
Cytoband	15q14	SNAP23 MGA	1.43e-03	49	52	2	15q14
Cytoband	2q21.1	CCDC74B CCDC74A	2.00e-03	58	52	2	2q21.1
GeneFamily	Ataxins\|Trinucleotide repeat containing	KMT2D MED12	1.00e-03	25	34	2	775
GeneFamily	Complement system\|Sushi domain containing	C8B ITGAM	2.08e-03	36	34	2	492
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	SETX SMARCA2 B3GNT7 SEC31A CSPP1	3.21e-06	199	51	5	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
Disease	Prostatic Neoplasms	TET2 KMT2D CTCF CIZ1 NGFR NCOA1 ZFHX3 MGA MED12	4.77e-07	616	47	9	C0033578
Disease	testosterone measurement	TET2 BMP6 WBP1L SMARCA2 SNAP23 NCOA1 ZFHX3 R3HDM2 SIN3A MIDEAS MED12 CRX	5.16e-07	1275	47	12	EFO_0004908
Disease	breast carcinoma (is_marker_for)	KMT2D CTCF NCOA1 ZFHX3	3.79e-06	66	47	4	DOID:3459 (is_marker_for)
Disease	Malignant neoplasm of prostate	TET2 KMT2D CIZ1 NGFR NCOA1 ZFHX3 MGA MED12	5.29e-06	616	47	8	C0376358
Disease	breast cancer (is_marker_for)	TET2 BMP6 KMT2D CTCF ZFHX3	1.14e-05	185	47	5	DOID:1612 (is_marker_for)
Disease	Phyllodes Tumor	KMT2D MED12	2.48e-05	5	47	2	C0010701
Disease	Malignant Cystosarcoma Phyllodes	KMT2D MED12	2.48e-05	5	47	2	C0600066
Disease	atherosclerosis (is_marker_for)	NGFR CASR ITGAM	2.83e-05	37	47	3	DOID:1936 (is_marker_for)
Disease	prostate cancer (is_marker_for)	BMP6 KMT2D SMARCA2 NCOA1	1.12e-04	156	47	4	DOID:10283 (is_marker_for)
Disease	creatinine measurement	TET2 WBP1L ZFHX3 R3HDM2 SIN3A PLEKHH2 BSN INTS8	1.59e-04	995	47	8	EFO_0004518
Disease	esophagus squamous cell carcinoma (is_marker_for)	TET2 BMP6 KMT2D	2.27e-04	74	47	3	DOID:3748 (is_marker_for)
Disease	T-Cell Lymphoma	KMT2D MGA	2.94e-04	16	47	2	C0079772
Disease	free androgen index	TET2 WBP1L SMARCA2 R3HDM2 SIN3A	3.16e-04	374	47	5	EFO_0007005
Disease	obesity (implicated_via_orthology)	BMP6 NCOA1 ZFHX3 MED12	3.82e-04	215	47	4	DOID:9970 (implicated_via_orthology)
Disease	coronary artery disease	TET2 DYNC2H1 WBP1L AAK1 R3HDM2 RAPGEF2 PLEKHH2 BSN	5.42e-04	1194	47	8	EFO_0001645
Disease	reaction time measurement	TET2 KMT2D EAPP CCAR1 NCOA1 ZFHX3	5.93e-04	658	47	6	EFO_0008393
Disease	apolipoprotein B measurement	ZFHX3 R3HDM2 C8B PLEKHH2 MIDEAS SCAF4	6.17e-04	663	47	6	EFO_0004615
Disease	Sezary Syndrome	TET2 KMT2D	8.50e-04	27	47	2	C0036920
Disease	household income	TET2 SMARCA2 RAPGEF2 BSN	1.39e-03	304	47	4	EFO_0009695
Disease	lung non-small cell carcinoma (is_implicated_in)	TET2 KMT2D ZFHX3	1.43e-03	139	47	3	DOID:3908 (is_implicated_in)
Disease	pulse pressure measurement	TET2 BMP6 DYNC2H1 WBP1L ZFHX3 IRF5 INTS8 GARRE1	1.46e-03	1392	47	8	EFO_0005763
Disease	Mammary Neoplasms	KMT2D CTCF DYNC2H1 NCOA1 MED12	1.47e-03	527	47	5	C1458155

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGRTNQPKQNQPTAI	CTCF	656	P49711
QLFLKQQQQQQQPPP	AAK1	466	Q2M2I8
LQTQPQPLLQQPQQK	CCAR1	261	Q8IX12
QPLTLPQQQRSQQQP	CASR	946	P41180
LGPQRSRQQQPVPNS	EAPP	161	Q56P03
PQSPQLRQSDPQKRN	CCDC74A	36	Q96AQ1
PQSPQLRQSDPQKRN	CCDC74B	36	Q96LY2
EPQGTQPAQQQQPCL	CHCHD2	101	Q9Y6H1
RGQQLPQPSQQPGLQ	R3HDM2	546	Q9Y2K5
QNQVQPPPDNKRNRI	INTS8	66	Q75QN2
QQQQQQGSRPPGLSK	MGA	976	Q8IWI9
PQTQQQQQGLGLQPP	BSN	3776	Q9UPA5
QLNQEQQQIPGKPGT	CSPP1	1231	Q1MSJ5
LVNASRQQPQQPAQP	LRRC24	361	Q50LG9
QQPAVPQGQRLRQQL	MED12	1901	Q93074
PGPFSQPKQQHQQQL	MICALL1	231	Q8N3F8
QSQQRLQPVAQAPPG	IRF5	466	Q13568
RQPQNQPGPLQGWQL	PLEKHH2	1031	Q8IVE3
LSGNRKRGQPQAPQQ	ERVK-5	606	Q9HDB9
NQNSNLIHQKVPPPN	DYNC2H1	4051	Q8NCM8
PNQKANPTPPNLRNN	GAB4	426	Q2WGN9
HGTQKRNQSRPQPQP	B3GAT2	61	Q9NPZ5
GLAPQQQSPKQQQPQ	GARRE1	716	O15063
EEQQQQQQLPRGEPP	BMP6	111	P22004
AAFPPQKQQQQQQPQ	MIDEAS	241	Q6PJG2
QKAQKPNGQLVNPNN	B3GNT7	46	Q8NFL0
LQQILQTFQQPPKPQ	SCAF4	201	O95104
RKTRQRQCNNPPPQN	C8B	561	P07358
QKQQQQPPGGQAKAR	CRX	101	O43186
SGPQPQLQQVPRGQN	POM121L1P	401	Q3SYA9
NNNPANGTQNKPRQP	PYGO1	296	Q9Y3Y4
RQQQPQPQPPKLQLQ	SUPT20HL1	721	Q3ZLR7
KPRQEQPQSQQQQPQ	SUPT20HL1	741	Q3ZLR7
APGQPSPVLQLQQKQ	SMARCA2	311	P51531
RSGMQQQITPQPPLN	NCOA1	1091	Q15788
SKQPGPVTNGQLQQP	SNAP23	116	O00161
GRQQQQKQQLPQTPP	FTSJ3	561	Q8IY81
PQSPNNSNRQGCKVP	SETX	1661	Q7Z333
PQLNNKPQRPSQNGC	SIN3A	411	Q96ST3
QRSQQQKQQGPLPAP	TANC1	1421	Q9C0D5
QNNPNPRSLVKPITQ	ITGAM	206	P11215
PQQPQQPLLNLQGTN	CIZ1	61	Q9ULV3
LKPQPQQLQQNLPKG	C11orf52	31	Q96A22
QQQPPPAHKINQGLQ	RAPGEF2	1041	Q9Y4G8
LQQLRAQEPPGSQQP	PLEKHG5	686	O94827
QRAQQQQVKQPCQPP	SPRR4	16	Q96PI1
NKQGANSRPVNQTPP	NGFR	281	P08138
NPLGDPQSQMLQQQP	SEC31A	1026	O94979
LQKQPPQPQQQQRPQ	TET2	1531	Q6N021
QLQQQQLLPPQCGPA	WBP1L	126	Q9NX94
PSAQPNQTQEKQGQP	ZFHX3	2436	Q15911
LQPPLRLPGQQQQQV	KMT2D	4091	O14686
QPPQEQQQLNGLISP	NAA30	76	Q147X3