Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	2.29e-22	114	39	14	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	7.88e-22	124	39	14	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	3.38e-21	137	39	14	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.37e-19	192	39	14	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 PCSK6 USP17L24 USP17L13 USP17L18	5.54e-13	654	39	15	GO:0008233
GeneOntologyMolecularFunction	DNA (cytosine-5-)-methyltransferase activity	DNMT3L DNMT3A	2.22e-05	4	39	2	GO:0003886
GeneOntologyMolecularFunction	DNA-methyltransferase activity	DNMT3L DNMT3A	7.76e-05	7	39	2	GO:0009008
GeneOntologyMolecularFunction	hyaluronic acid binding	USP17L6P USP17L24	1.46e-03	29	39	2	GO:0005540
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	5.66e-22	125	39	14	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.45e-21	144	39	14	GO:0070646
GeneOntologyBiologicalProcess	post-translational protein modification	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 HDAC7 USP17L11 USP17L15 TRIM23 USP17L24 LCMT1 USP17L13 USP17L18	2.31e-12	1074	39	17	GO:0043687
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 HDAC7 USP17L11 USP17L15 TRIM23 USP17L24 USP17L13 USP17L18	1.25e-11	1009	39	16	GO:0070647
GeneOntologyBiologicalProcess	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	USP17L6P USP17L24	9.68e-05	8	39	2	GO:0071947
GeneOntologyBiologicalProcess	autosome genomic imprinting	DNMT3L DNMT3A	1.24e-04	9	39	2	GO:0141068
GeneOntologyCellularComponent	endoplasmic reticulum membrane	USP17L6P USP17L5 USP17L21 USP17L10 DHRS4 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	2.66e-08	1293	38	14	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	USP17L6P USP17L5 USP17L21 USP17L10 DHRS4 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	2.82e-08	1299	38	14	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	USP17L6P USP17L5 USP17L21 USP17L10 DHRS4 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	3.68e-08	1327	38	14	GO:0042175
GeneOntologyCellularComponent	heterochromatin	KDM4E DNMT3L DNMT3A	8.17e-04	101	38	3	GO:0000792
MousePheno	increased trophectoderm apoptosis	USP17L15 USP17L13	5.99e-05	8	21	2	MP:0012119
MousePheno	decreased regulatory T cell number	CD27 USP17L15 USP17L13	1.15e-04	64	21	3	MP:0004974
MousePheno	abnormal DNA methylation during gametogenesis	DNMT3L DNMT3A	1.17e-04	11	21	2	MP:0008878
MousePheno	abnormal imprinting	DNMT3L DNMT3A	2.88e-04	17	21	2	MP:0003787
Domain	HABP4_PAI-RBP1	USP17L5 USP17L21 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18	1.08e-27	16	36	11	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L5 USP17L21 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18	1.08e-27	16	36	11	IPR006861
Domain	USP_CS	USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18	1.54e-21	66	36	12	IPR018200
Domain	USP_1	USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18	3.32e-21	70	36	12	PS00972
Domain	UCH	USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18	3.99e-21	71	36	12	PF00443
Domain	USP_2	USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18	3.99e-21	71	36	12	PS00973
Domain	USP_3	USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18	4.78e-21	72	36	12	PS50235
Domain	USP_dom	USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18	4.78e-21	72	36	12	IPR028889
Domain	Peptidase_C19_UCH	USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L24 USP17L13 USP17L18	4.78e-21	72	36	12	IPR001394
Domain	ADD	DNMT3L DNMT3A	2.16e-05	4	36	2	IPR025766
Domain	ADD	DNMT3L DNMT3A	2.16e-05	4	36	2	PS51533
Domain	-	HHIPL1 TENM4	2.56e-03	39	36	2	2.120.10.30
Domain	Znf_FYVE_PHD	TCF20 DNMT3L DNMT3A	2.82e-03	147	36	3	IPR011011
Domain	6-blade_b-propeller_TolB-like	HHIPL1 TENM4	3.54e-03	46	36	2	IPR011042
Pathway	REACTOME_RAS_PROCESSING	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	6.08e-26	45	30	13	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	3.36e-17	191	30	13	MM15289
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	2.30e-16	221	30	13	M27578
Pathway	REACTOME_DEUBIQUITINATION	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	2.12e-15	262	30	13	MM15286
Pathway	REACTOME_DEUBIQUITINATION	USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	1.18e-14	299	30	13	M27574
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	2.60e-14	318	30	13	MM15278
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 HDAC7 USP17L11 USP17L15 USP17L24 USP17L13 DNMT3A USP17L18	6.22e-08	1475	30	15	M19806
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 HDAC7 USP17L11 USP17L15 USP17L13 USP17L18	2.43e-07	1389	30	14	MM15307
Pathway	KEGG_CYSTEINE_AND_METHIONINE_METABOLISM	DNMT3L DNMT3A	2.35e-03	34	30	2	M10911
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	9.42e-35	21	39	13	12447969
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	9.42e-35	21	39	13	11468161
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	9.42e-35	21	39	13	18980247
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	9.42e-35	21	39	13	8756639
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	9.42e-35	21	39	13	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	9.42e-35	21	39	13	14583620
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	2.30e-34	22	39	13	9154835
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	2.81e-34	33	39	14	20228807
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	19188362
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	20715989
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	17109758
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	11941478
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	15780755
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	14699124
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	20403174
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	4.78e-34	34	39	14	21448158
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	7.96e-34	35	39	14	21239494
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	7.96e-34	35	39	14	16611142
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	1.15e-33	24	39	13	8995226
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	1.30e-33	36	39	14	20147298
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	2.09e-33	37	39	14	20228808
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	2.40e-33	25	39	13	21115691
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	4.80e-33	26	39	13	35816173
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	3.12e-32	29	39	13	32527007
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	1.61e-28	50	39	13	31806660
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 TENM4 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	8.90e-15	674	39	14	37196079
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	USP17L21 USP17L19 USP17L12 USP17L17 USP17L20 USP17L11 USP17L18	6.45e-11	119	39	7	28625976
Pubmed	The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L.	DNMT3L DNMT3A	1.23e-06	2	39	2	20630873
Pubmed	Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells.	DNMT3L DNMT3A	1.23e-06	2	39	2	38627502
Pubmed	The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a.	DNMT3L DNMT3A	1.23e-06	2	39	2	12481029
Pubmed	HBx induces hypomethylation of distal intragenic CpG islands required for active expression of developmental regulators.	DNMT3L DNMT3A	1.23e-06	2	39	2	24941955
Pubmed	Both combinatorial K4me0-K36me3 marks on sister histone H3s of a nucleosome are required for Dnmt3a-Dnmt3L mediated de novo DNA methylation.	DNMT3L DNMT3A	1.23e-06	2	39	2	32173286
Pubmed	CG dinucleotide periodicities recognized by the Dnmt3a-Dnmt3L complex are distinctive at retroelements and imprinted domains.	DNMT3L DNMT3A	1.23e-06	2	39	2	19921333
Pubmed	Dynamic CpG island methylation landscape in oocytes and preimplantation embryos.	DNMT3L DNMT3A	1.23e-06	2	39	2	21706000
Pubmed	Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family.	DNMT3L DNMT3A	1.23e-06	2	39	2	15861382
Pubmed	Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.	DNMT3L DNMT3A	1.23e-06	2	39	2	17713477
Pubmed	Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation.	DNMT3L DNMT3A	1.23e-06	2	39	2	16999741
Pubmed	Forced expression of DNA methyltransferases during oocyte growth accelerates the establishment of methylation imprints but not functional genomic imprinting.	DNMT3L DNMT3A	1.23e-06	2	39	2	24599402
Pubmed	Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L.	DNMT3L DNMT3A	1.23e-06	2	39	2	18945701
Pubmed	Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L.	DNMT3L DNMT3A	3.67e-06	3	39	2	15671018
Pubmed	DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells.	DNMT3L DNMT3A	3.67e-06	3	39	2	30321403
Pubmed	Gene-specific timing and epigenetic memory in oocyte imprinting.	DNMT3L DNMT3A	3.67e-06	3	39	2	14998934
Pubmed	Co-expression of de novo DNA methyltransferases Dnmt3a2 and Dnmt3L in gonocytes of mouse embryos.	DNMT3L DNMT3A	3.67e-06	3	39	2	15567719
Pubmed	Genetic evidence for a maternal effect locus controlling genomic imprinting and growth.	DNMT3L DNMT3A	3.67e-06	3	39	2	16283622
Pubmed	DNA methyltransferase expression in the mouse germ line during periods of de novo methylation.	DNMT3L DNMT3A	3.67e-06	3	39	2	15739230
Pubmed	Coordinate regulation of DNA methyltransferase expression during oogenesis.	DNMT3L DNMT3A	3.67e-06	3	39	2	17445268
Pubmed	DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction.	DNMT3L DNMT3A	3.67e-06	3	39	2	15105426
Pubmed	In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases.	DNMT3L DNMT3A	3.67e-06	3	39	2	22761581
Pubmed	Structural insight into autoinhibition and histone H3-induced activation of DNMT3A.	DNMT3L DNMT3A	3.67e-06	3	39	2	25383530
Pubmed	Interactions within the mammalian DNA methyltransferase family.	DNMT3L DNMT3A	3.67e-06	3	39	2	12777184
Pubmed	Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse.	DNMT3L DNMT3A	3.67e-06	3	39	2	17616512
Pubmed	DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo.	DNMT3L DNMT3A	3.67e-06	3	39	2	20838592
Pubmed	Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development.	DNMT3L DNMT3A	3.67e-06	3	39	2	18544626
Pubmed	Human intelligence and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking.	DNMT3L DNMT3A	7.34e-06	4	39	2	20593030
Pubmed	DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes.	DNMT3L DNMT3A	7.34e-06	4	39	2	18381894
Pubmed	De novo DNA methylation drives 5hmC accumulation in mouse zygotes.	DNMT3L DNMT3A	7.34e-06	4	39	2	26751286
Pubmed	De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes.	DNMT3L DNMT3A	7.34e-06	4	39	2	18953337
Pubmed	The loss of global DNA methylation due to decreased DNMT expression in the postnatal mouse ovaries may associate with infertility emerging during ovarian aging.	DNMT3L DNMT3A	7.34e-06	4	39	2	32514790
Pubmed	De novo DNA methylation through the 5'-segment of the H19 ICR maintains its imprint during early embryogenesis.	DNMT3L DNMT3A	7.34e-06	4	39	2	26417043
Pubmed	Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.	USP17L15 USP17L13	7.34e-06	4	39	2	22984479
Pubmed	Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases.	DNMT3L DNMT3A	7.34e-06	4	39	2	23637617
Pubmed	Superovulation induces defective methylation in line-1 retrotransposon elements in blastocyst.	DNMT3L DNMT3A	7.34e-06	4	39	2	23866265
Pubmed	Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs.	DNMT3L DNMT3A	1.22e-05	5	39	2	24074865
Pubmed	A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation.	DNMT3L DNMT3A	1.22e-05	5	39	2	19246518
Pubmed	Windows for sex-specific methylation marked by DNA methyltransferase expression profiles in mouse germ cells.	DNMT3L DNMT3A	1.22e-05	5	39	2	15063176
Pubmed	Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice.	DNMT3L DNMT3A	2.56e-05	7	39	2	30834655
Pubmed	Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions.	DNMT3L DNMT3A	2.56e-05	7	39	2	31558711
Pubmed	Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice.	DNMT3L DNMT3A	2.56e-05	7	39	2	11934864
Pubmed	DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.	DNMT3L DNMT3A	2.56e-05	7	39	2	17687327
Pubmed	Telomere lengthening early in development.	DNMT3L DNMT3A	2.56e-05	7	39	2	17982445
Pubmed	KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints.	DNMT3L DNMT3A	3.42e-05	8	39	2	19727073
Pubmed	Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog.	DNMT3L DNMT3A	3.42e-05	8	39	2	17938196
Pubmed	SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation.	DNMT3L DNMT3A	3.42e-05	8	39	2	32674113
Pubmed	Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo.	DNMT3L DNMT3A	3.42e-05	8	39	2	23293288
Pubmed	ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1.	DNMT3L DNMT3A	4.39e-05	9	39	2	38237590
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L6P USP17L15	5.48e-05	10	39	2	24207026
Pubmed	The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation.	DNMT3L DNMT3A	5.48e-05	10	39	2	17048991
Pubmed	DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis.	DNMT3L DNMT3A	6.70e-05	11	39	2	35410378
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L6P USP17L15	8.03e-05	12	39	2	24695638
Pubmed	Cytoplasmic compartmentalization of the fetal piRNA pathway in mice.	DNMT3L DNMT3A	8.03e-05	12	39	2	20011505
Pubmed	SWI/SNF chromatin remodeling complex is required for initiation of sex-dependent differentiation in mouse germline.	DNMT3L DNMT3A	9.48e-05	13	39	2	34912016
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L6P USP17L15	1.11e-04	14	39	2	11793228
Pubmed	Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres.	DNMT3L DNMT3A	1.46e-04	16	39	2	18784354
Pubmed	An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.	ZBTB10 DNMT3L DNMT3A	1.48e-04	91	39	3	20362542
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L6P USP17L15	2.07e-04	19	39	2	28067227
Pubmed	The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.	DNMT3L DNMT3A	2.30e-04	20	39	2	20059948
Pubmed	Rex1/Zfp42 as an epigenetic regulator for genomic imprinting.	DNMT3L DNMT3A	4.23e-04	27	39	2	21233130
Interaction	FLT3 interactions	USP17L21 USP17L19 USP17L12 USP17L17 USP17L20 USP17L11 USP17L18	8.51e-07	318	34	7	int:FLT3
Interaction	ZNF250 interactions	GUCD1 ZCCHC7 YJU2B TRIM23	5.84e-05	126	34	4	int:ZNF250
Cytoband	4p16.1	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	8.59e-30	79	39	14	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	3.42e-23	222	39	14	chr4p16
Coexpression	MADAN_DPPA4_TARGETS	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	6.60e-24	86	37	13	MM1312
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	2.52e-22	112	37	13	MM1095
Coexpression	GERY_CEBP_TARGETS	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	3.12e-20	160	37	13	MM1155
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 CD27 USP17L20 USP17L11 USP17L15 USP17L13 USP17L18	9.82e-14	647	37	14	MM981
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 COA7 USP17L11 USP17L15 USP17L13 USP17L18	8.53e-11	1072	37	14	MM1031
Coexpression	BRUINS_UVC_RESPONSE_LATE	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 LCMT1 USP17L13 USP17L18	3.67e-10	1198	37	14	MM1062
Coexpression	GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 LCMT1 USP17L13 USP17L18	4.95e-10	1226	37	14	MM979
Coexpression	GSE3565_CTRL_VS_LPS_INJECTED_SPLENOCYTES_DN	TCF20 ALS2CL CD27 DNMT3A	1.07e-04	175	37	4	M6328
Coexpression	GSE3565_DUSP1_VS_WT_SPLENOCYTES_DN	TCF20 CD27 HDAC7 DNMT3A	1.16e-04	179	37	4	M6324
Coexpression	GSE39916_B_CELL_SPLEEN_VS_PLASMA_CELL_BONE_MARROW_UP	GUCD1 ALS2CL YJU2B DNMT3A	1.75e-04	199	37	4	M9269
Drug	vinclozolin	TCF20 DNMT3L DNMT3A	2.48e-05	48	27	3	CID000039676
Drug	5-bromocytosine	DNMT3L DNMT3A	6.06e-05	10	27	2	CID000075233
Drug	Tropine [120-29-6]; Down 200; 28.4uM; HL60; HT_HG-U133A	ALS2CL SGCB TRIM23 PCSK6	8.00e-05	196	27	4	6147_DN
Drug	Methyldopate hydrochloride [2508-79-4]; Up 200; 14.6uM; MCF7; HT_HG-U133A	ALS2CL PCSK6 ANGEL2 DNMT3A	8.16e-05	197	27	4	7360_UP
Drug	Propafenone hydrochloride [34183-22-7]; Down 200; 10.6uM; MCF7; HT_HG-U133A	SGCB TRIM23 ANGEL2 DNMT3A	8.16e-05	197	27	4	2871_DN
Drug	Cefoxitin sodium salt [33564-30-6]; Up 200; 8.8uM; MCF7; HT_HG-U133A	SGCB HDAC7 PCSK6 DNMT3A	8.32e-05	198	27	4	3477_UP
Drug	Sulfanilamide [63-74-1]; Down 200; 23.2uM; MCF7; HT_HG-U133A	ALS2CL HDAC7 PCSK6 ANGEL2	8.49e-05	199	27	4	6810_DN
Drug	troglitazone; Up 200; 10uM; HL60; HT_HG-U133A	SGCB HDAC7 TRIM23 DNMT3A	8.49e-05	199	27	4	6191_UP
Drug	Naproxen [22204-53-1]; Up 200; 17.4uM; HL60; HT_HG-U133A	ALS2CL HDAC7 COA7 PCSK6	8.65e-05	200	27	4	1869_UP
Drug	C-E6	DNMT3L DNMT3A	8.87e-05	12	27	2	CID000444208
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	3.30e-31	46	37	14	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L6P USP17L5 USP17L21 USP17L10 USP17L19 USP17L12 USP17L22 USP17L17 USP17L20 USP17L11 USP17L15 USP17L24 USP17L13 USP17L18	2.09e-28	69	37	14	DOID:1682 (implicated_via_orthology)
Disease	mean arterial pressure	ZBTB10 ZCCHC7 TCF20 SLCO6A1 HDAC7	3.78e-04	499	37	5	EFO_0006340
Disease	isthmus cingulate cortex volume measurement	TENM4 TCF20	4.88e-04	26	37	2	EFO_0010310
Disease	Mental deterioration	TENM4 SLCO6A1	6.08e-04	29	37	2	HP_0001268
Disease	bipolar disorder	TENM4 ZCCHC7 TCF20 HDAC7	5.73e-03	577	37	4	MONDO_0004985

Protein segments in the cluster

Peptide	Gene	Start	Entry
FDCYKCHWREGSMCG	ALS2CL	406	Q60I27
HYWAQGKLCCQMCEP	CD27	31	P26842
WNCYMCGHKGTYGLL	DNMT3A	581	Q9Y6K1
SGKVHAMSNWVCYLC	DNMT3L	131	Q9UJW3
GPGYWMCCHRSQKGF	FBXO34	661	Q9NWN3
MEAWRCVRKGYGHCV	ANGEL2	1	Q5VTE6
MHKAGLLGLCARAWN	DHRS4	1	Q9BTZ2
NTCIYTEGWKCMAGR	PATE4	26	P0C8F1
RFHEGMKSWSCCGIQ	ITGB1BP2	176	Q9UKP3
CQDYCLDMWHKCRGL	HHIPL1	111	Q96JK4
SNMWYLHCGDKNSRC	PCSK6	166	P29122
RWIDYGKMASQCSCG	KDM4E	296	B2RXH2
QQLYHWDCGLACSRM	GUCD1	26	Q96NT3
HSKYWGCMQRLASCP	HDAC7	891	Q8WUI4
LMRHYCLCWATKGGN	LCMT1	311	Q9UIC8
CGHTGRCWIYNKTKM	SLCO6A1	651	Q86UG4
QLGSGDWVRYKLCMC	SGCB	276	Q16585
ACKYSMKACDLGHIW	COA7	171	Q96BR5
LGHIWACANASRMYK	COA7	181	Q96BR5
IQMTRGYSGWKLCDC	ZNF561	106	Q8N587
IFGGYWRSQIKCLHC	USP17L18	196	D6R9N7
IFGGYWRSQIKCLHC	USP17L5	196	A8MUK1
IFGGYWRSQIKCLHC	USP17L21	196	D6R901
IFGGYWRSQIKCLHC	USP17L13	196	C9JLJ4
QYMKGRCLCHSGWKG	TENM4	606	Q6N022
IFGGYWRSQIKCLHC	USP17L19	196	D6RCP7
CLCGKWASYRNMGDL	TCF20	1706	Q9UGU0
PYNIWCDGCKNHIGM	YJU2B	51	P13994
IFGGYWRSQIKCLHC	USP17L12	196	C9JPN9
IFGGYWRSQIKCLHC	USP17L24	196	Q0WX57
SWDKQCDRCHMLGHY	ZCCHC7	301	Q8N3Z6
LRYSKDTGLMSCGWC	ZBTB10	261	Q96DT7
IFGGYWRSQIKCLHC	USP17L6P	196	Q6QN14
SLHKLCCGRSWYIQG	TRIM23	531	P36406
IFGGYWRSQIKCLHC	USP17L22	196	D6RA61
IFGGYWRSQIKCLHC	USP17L15	196	C9J2P7
IFGGYWRSQIKCLHC	USP17L17	196	D6RBQ6
GYAWISPCKMSLHFC	THEG	151	Q9P2T0
IFGGYWRSQIKCLHC	USP17L20	196	D6RJB6
IFGGYWRSQIKCLHC	USP17L10	196	C9JJH3
IFGGYWRSQIKCLHC	USP17L11	196	C9JVI0