Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

MOXD2P EGLN3 KDM5A CYP4B1 EGLN1 FAXDC2 CYP46A1 FMO6P

3.18e-06194928GO:0016705
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

GABRD GABRP SCN11A SLC46A3 ATP2C1 KCNH8 KCNG1 SLC5A6 SLC28A3 ABCC2 SLC13A2 KCNH3 GABRA2

4.31e-057589213GO:0015318
GeneOntologyMolecularFunctionGABA-A receptor activity

GABRD GABRP GABRA2

8.69e-0519923GO:0004890
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GABRD GABRP ADRB1 P2RY11 GABRA2

9.92e-05100925GO:0030594
GeneOntologyMolecularFunctionhypoxia-inducible factor-proline dioxygenase activity

EGLN3 EGLN1

1.25e-044922GO:0160082
GeneOntologyMolecularFunctionGABA receptor activity

GABRD GABRP GABRA2

1.37e-0422923GO:0016917
GeneOntologyMolecularFunctionmonooxygenase activity

MOXD2P CYP4B1 FAXDC2 CYP46A1 FMO6P

1.92e-04115925GO:0004497
GeneOntologyMolecularFunctiontransporter activity

GABRD GABRP SCN11A ATG9B SLC46A3 ATP2C1 KCNH8 RHBDF2 KCNG1 SLC5A6 SLC28A3 ATG2A ABCC2 SLC13A2 KCNH3 GABRA2

2.47e-0412899216GO:0005215
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

GABRD GABRP SCN11A SLC46A3 ATP2C1 KCNH8 KCNG1 SLC5A6 SLC28A3 SLC13A2 KCNH3 GABRA2

2.78e-047939212GO:0015075
GeneOntologyMolecularFunctionretinoic acid binding

UGT1A4 UGT1A3 UGT1A5

2.85e-0428923GO:0001972
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SCN11A SLC46A3 ATP2C1 KCNH8 KCNG1 SLC5A6 SLC28A3 SLC13A2 KCNH3

2.93e-04465929GO:0046873
GeneOntologyMolecularFunctionglucuronosyltransferase activity

UGT1A4 UGT1A3 UGT1A5

5.57e-0435923GO:0015020
GeneOntologyMolecularFunctionpeptidyl-proline 4-dioxygenase activity

EGLN3 EGLN1

5.77e-048922GO:0031545
GeneOntologyMolecularFunctioniron ion binding

EGLN3 CYP4B1 EGLN1 FAXDC2 CYP46A1

1.03e-03166925GO:0005506
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

GABRD GABRP SLC5A6 ABCC2 GABRA2

1.17e-03171925GO:0015103
GeneOntologyMolecularFunctionpeptidyl-proline dioxygenase activity

EGLN3 EGLN1

1.34e-0312922GO:0031543
GeneOntologyMolecularFunctionretinoid binding

UGT1A4 UGT1A3 UGT1A5

1.41e-0348923GO:0005501
GeneOntologyMolecularFunctionisoprenoid binding

UGT1A4 UGT1A3 UGT1A5

1.50e-0349923GO:0019840
GeneOntologyMolecularFunctionligase activity, forming carbon-nitrogen bonds

GMPS TTLL11 TTLL8

1.88e-0353923GO:0016879
GeneOntologyMolecularFunctionglucosidase activity

KL MGAM2

2.12e-0315922GO:0015926
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SCN11A SLC46A3 ATP2C1 KCNH8 KCNG1 SLC5A6 SLC28A3 SLC13A2 KCNH3

2.40e-03627929GO:0022890
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GABRD ADRB1 GABRA2

2.68e-0360923GO:0099529
GeneOntologyMolecularFunctiontransmembrane transporter activity

GABRD GABRP SCN11A SLC46A3 ATP2C1 KCNH8 KCNG1 SLC5A6 SLC28A3 ABCC2 SLC13A2 KCNH3 GABRA2

2.88e-0311809213GO:0022857
GeneOntologyMolecularFunctionGABA-gated chloride ion channel activity

GABRP GABRA2

3.06e-0318922GO:0022851
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GABRD GABRP GABRA2

3.36e-0365923GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GABRD GABRP GABRA2

3.36e-0365923GO:0022824
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

EGLN3 KDM5A EGLN1

3.36e-0365923GO:0016706
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SCN11A SLC46A3 ATP2C1 KCNH8 KCNG1 SLC5A6 SLC28A3 SLC13A2 KCNH3

3.51e-03664929GO:0008324
GeneOntologyMolecularFunctionL-ascorbic acid binding

EGLN3 EGLN1

3.78e-0320922GO:0031418
GeneOntologyMolecularFunctionmanganese ion binding

XYLT2 ATP2C1 PIM1

4.31e-0371923GO:0030145
GeneOntologyMolecularFunctiongated channel activity

GABRD GABRP KCNH8 KCNG1 KCNH3 GABRA2

4.48e-03334926GO:0022836
GeneOntologyMolecularFunctioncarboxylic acid binding

UGT1A4 UGT1A3 EGLN3 UGT1A5 EGLN1

4.98e-03239925GO:0031406
GeneOntologyMolecularFunctionacid-amino acid ligase activity

TTLL11 TTLL8

4.99e-0323922GO:0016881
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GABRD ADRB1 GABRA2

5.03e-0375923GO:0098960
GeneOntologyMolecularFunctionsymporter activity

SLC46A3 SLC5A6 SLC28A3 SLC13A2

5.13e-03150924GO:0015293
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

GABRD GABRP SLC5A6 GABRA2

5.25e-03151924GO:0008509
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GABRD GABRP SCN11A KCNH8 KCNG1 KCNH3 GABRA2

5.30e-03459927GO:0005216
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GABRD GABRP GABRA2

5.41e-0377923GO:0005230
GeneOntologyMolecularFunctionUDP-glycosyltransferase activity

UGT1A4 UGT1A3 XYLT2 UGT1A5

5.49e-03153924GO:0008194
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

GABRD GABRP SCN11A TCAF1 SLC46A3 ATP2C1 ADRB1 KCNH8 KCNG1 SLC5A6 PHB2 SLC28A3 ABCC2 SLC13A2 KCNH3 GABRA2

3.10e-0511159216GO:0034220
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

GABRD GABRP SCN11A SLC46A3 ATP2C1 ADRB1 KCNH8 KCNG1 SLC5A6 PHB2 SLC28A3 ABCC2 SLC13A2 KCNH3 GABRA2

4.14e-0510179215GO:0098660
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

GABRD GABRP TCAF1 SLC5A6 ABCC2 GABRA2

6.37e-05153926GO:0098656
GeneOntologyBiologicalProcesscellular glucuronidation

UGT1A4 UGT1A3 UGT1A5

1.08e-0421923GO:0052695
GeneOntologyBiologicalProcessmonoatomic anion transport

GABRD GABRP TCAF1 SLC5A6 ABCC2 GABRA2

1.70e-04183926GO:0006820
GeneOntologyBiologicalProcessregulation of membrane potential

GABRD GABRP SCN11A XIRP1 ADRB1 KCNH8 KCNG1 POPDC3 KCNH3 GABRA2

1.94e-045599210GO:0042391
GeneOntologyBiologicalProcessglucuronate metabolic process

UGT1A4 UGT1A3 UGT1A5

2.07e-0426923GO:0019585
GeneOntologyBiologicalProcesschondroitin sulfate proteoglycan biosynthetic process

XYLT2 PXYLP1 CHST3

2.07e-0426923GO:0050650
GeneOntologyBiologicalProcessuronic acid metabolic process

UGT1A4 UGT1A3 UGT1A5

2.07e-0426923GO:0006063
GeneOntologyCellularComponentGABA-A receptor complex

GABRD GABRP GABRA2

7.84e-0519933GO:1902711
GeneOntologyCellularComponentGABA receptor complex

GABRD GABRP GABRA2

1.07e-0421933GO:1902710
DomainK_chnl_volt-dep_ELK

KCNH8 KCNH3

6.72e-053892IPR003950
DomainPIM1/2/3

PIM3 PIM1

6.72e-053892IPR017348
DomainUDPGT

UGT1A4 UGT1A3 UGT1A5

1.31e-0421893PF00201
DomainUDPGT

UGT1A4 UGT1A3 UGT1A5

1.31e-0421893PS00375
DomainUDP_glucos_trans

UGT1A4 UGT1A3 UGT1A5

1.31e-0421893IPR002213
DomainGABAA/Glycine_rcpt

GABRD GABRP GABRA2

1.73e-0423893IPR006028
DomaincNMP-bd-like

KCNH8 POPDC3 KCNH3

7.82e-0438893IPR018490
DomainPAS_9

KCNH8 KCNH3

9.86e-0410892PF13426
Domain2OG-FeII_Oxy_3

EGLN3 EGLN1

1.20e-0311892PF13640
DomainNeurotransmitter_ion_chnl_CS

GABRD GABRP GABRA2

1.28e-0345893IPR018000
DomainNeur_chan_memb

GABRD GABRP GABRA2

1.37e-0346893PF02932
DomainClass_I_gatase-like

GMPS TCAF1

1.44e-0312892IPR029062
DomainNeur_chan_LBD

GABRD GABRP GABRA2

1.46e-0347893PF02931
DomainNEUROTR_ION_CHANNEL

GABRD GABRP GABRA2

1.46e-0347893PS00236
DomainNeurotrans-gated_channel_TM

GABRD GABRP GABRA2

1.46e-0347893IPR006029
Domain-

GABRD GABRP GABRA2

1.46e-03478932.70.170.10
DomainNeur_channel

GABRD GABRP GABRA2

1.46e-0347893IPR006201
DomainNeur_chan_lig-bd

GABRD GABRP GABRA2

1.46e-0347893IPR006202
Domain-

KCNH8 POPDC3 KCNH3

1.55e-03488932.60.120.10
DomainRmlC-like_jellyroll

KCNH8 POPDC3 KCNH3

1.85e-0351893IPR014710
DomainK_chnl_volt-dep_EAG/ELK/ERG

KCNH8 KCNH3

1.97e-0314892IPR003938
DomainIon_trans_dom

SCN11A KCNH8 KCNG1 KCNH3

2.16e-03114894IPR005821
DomainIon_trans

SCN11A KCNH8 KCNG1 KCNH3

2.16e-03114894PF00520
DomainP4Hc

EGLN3 EGLN1

2.58e-0316892SM00702
DomainPro_4_hyd_alph

EGLN3 EGLN1

2.58e-0316892IPR006620
Domain2OG-FeII_Oxy

EGLN3 EGLN1

3.64e-0319892PF03171
DomainFE2OG_OXY

EGLN3 EGLN1

4.45e-0321892PS51471
DomainPAS_fold_3

KCNH8 KCNH3

5.32e-0323892IPR013655
DomainPAS_3

KCNH8 KCNH3

5.32e-0323892PF08447
DomainOxoglu/Fe-dep_dioxygenase

EGLN3 EGLN1

5.32e-0323892IPR005123
DomainPAS-assoc_C

KCNH8 KCNH3

5.79e-0324892IPR000700
DomainPAC

KCNH8 KCNH3

6.77e-0326892IPR001610
DomainPAC

KCNH8 KCNH3

6.77e-0326892SM00086
DomainPAC

KCNH8 KCNH3

6.77e-0326892PS50113
PathwayREACTOME_ATORVASTATIN_ADME

UGT1A4 UGT1A3 UGT1A5 ABCC2

7.73e-0715714MM15697
PathwayREACTOME_HEME_DEGRADATION

UGT1A4 UGT1A3 UGT1A5 ABCC2

2.69e-0620714MM14721
PathwayREACTOME_DRUG_ADME

UGT1A4 GMPS UGT1A3 UGT1A5 SLC28A3 ABCC2

1.77e-05109716M45012
PathwayREACTOME_METABOLISM_OF_PORPHYRINS

UGT1A4 UGT1A3 UGT1A5 ABCC2

1.91e-0532714MM14719
PathwayREACTOME_DRUG_ADME

UGT1A4 GMPS UGT1A3 UGT1A5 SLC28A3 ABCC2

2.92e-05119716MM15692
PathwayREACTOME_ASPIRIN_ADME

UGT1A4 UGT1A3 UGT1A5 ABCC2

6.89e-0544714M45014
PathwayREACTOME_ASPIRIN_ADME

UGT1A4 UGT1A3 UGT1A5 ABCC2

7.53e-0545714MM15694
PathwayWP_METAPATHWAY_BIOTRANSFORMATION

UGT1A4 UGT1A3 CYP4B1 UGT1A5 CYP46A1 CHST3

1.19e-04153716MM15844
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

UGT1A4 GMPS UGT1A3 UGT1A5

1.23e-0451714M17726
PathwayREACTOME_PREDNISONE_ADME

UGT1A4 UGT1A3 UGT1A5

2.02e-0423713MM16639
PathwayREACTOME_GLUCURONIDATION

UGT1A4 UGT1A3 UGT1A5

2.30e-0424713MM14599
PathwayREACTOME_GLUCURONIDATION

UGT1A4 UGT1A3 UGT1A5

2.60e-0425713M17787
PathwayWP_GLUCURONIDATION

UGT1A4 UGT1A3 UGT1A5

2.60e-0425713MM15820
PathwayKEGG_ASCORBATE_AND_ALDARATE_METABOLISM

UGT1A4 UGT1A3 UGT1A5

2.60e-0425713M605
PathwayWP_GLUCURONIDATION

UGT1A4 UGT1A3 UGT1A5

2.93e-0426713M39404
PathwayWP_METAPATHWAY_BIOTRANSFORMATION_PHASE_I_AND_II

UGT1A4 UGT1A3 CYP4B1 UGT1A5 CYP46A1 CHST3

3.14e-04183716M39588
PathwayKEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS

UGT1A4 UGT1A3 UGT1A5

3.66e-0428713M19580
PathwayWP_GABA_RECEPTOR_SIGNALING

GABRD GABRP GABRA2

4.97e-0431713M39369
PathwayREACTOME_ATORVASTATIN_ADME

UGT1A3 ABCC2

8.80e-049712M45020
PathwayWP_MBDNF_AND_PROBDNF_REGULATION_OF_GABA_NEUROTRANSMISSION

GABRD GABRP GABRA2

9.10e-0438713M39854
PathwayKEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM

UGT1A4 UGT1A3 UGT1A5

1.14e-0341713M7399
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNH8 KCNG1 KCNH3

1.14e-0341713MM14546
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNH8 KCNG1 KCNH3

1.31e-0343713M1056
Pubmed

Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.

UGT1A4 UGT1A3 CYP4B1 UGT1A5 SLC5A6 FMO6P

2.64e-086694619898482
Pubmed

Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.

UGT1A4 UGT1A3 UGT1A5 PLEC

4.91e-081494414672974
Pubmed

A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.

UGT1A4 UGT1A3 UGT1A5

1.59e-06994322511988
Pubmed

A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.

UGT1A4 UGT1A3 UGT1A5

1.59e-0699431339448
Pubmed

Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.

UGT1A4 UGT1A3 UGT1A5

2.26e-061094323642732
Pubmed

UDP-glucuronosyltransferases.

UGT1A4 UGT1A3 UGT1A5

2.26e-061094311465080
Pubmed

A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.

UGT1A4 UGT1A3 UGT1A5

2.26e-061094323371916
Pubmed

A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.

UGT1A4 UGT1A3 UGT1A5

2.26e-061094322558097
Pubmed

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

UGT1A4 UGT1A3 UGT1A5

4.13e-061294319419973
Pubmed

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.

UGT1A4 UGT1A3 UGT1A5

4.13e-061294311434514
Pubmed

UGT1A1 is a major locus influencing bilirubin levels in African Americans.

UGT1A4 UGT1A3 UGT1A5

5.36e-061394322085899
Pubmed

Genome-wide analysis of hepatic lipid content in extreme obesity.

UGT1A4 UGT1A3 UGT1A5

5.36e-061394325246029
Pubmed

Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.

UGT1A4 UGT1A3 UGT1A5

6.81e-061494321646302
Pubmed

Human UDP-glucuronosyltransferases: metabolism, expression, and disease.

UGT1A4 UGT1A3 UGT1A5

6.81e-061494310836148
Pubmed

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

UGT1A4 UGT1A3 UGT1A5

6.81e-06149439295054
Pubmed

Low nuclear expression of HIF-hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence-free survival in clear cell renal cell carcinoma.

EGLN3 EGLN1

7.23e-06294238400673
Pubmed

Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

UGT1A3 UGT1A5

7.23e-0629428068691
Pubmed

SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiation.

EGLN3 EGLN1

7.23e-06294210543731
Pubmed

Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.

UGT1A4 UGT1A3

7.23e-06294224641623
Pubmed

Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction.

EGLN3 EGLN1

7.23e-06294231356139
Pubmed

Self-renewal of murine embryonic stem cells is supported by the serine/threonine kinases Pim-1 and Pim-3.

PIM3 PIM1

7.23e-06294217717068
Pubmed

GTP is an allosteric modulator of the interaction between the guanylate-binding protein 1 and the prosurvival kinase PIM1.

PIM1 GBP1

7.23e-06294225081641
Pubmed

The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia.

EGLN3 EGLN1

7.23e-06294219737309
Pubmed

Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus.

GABRD GABRA2

7.23e-06294214627650
Pubmed

Kv12-encoded K+ channels drive the day-night switch in the repetitive firing rates of SCN neurons.

KCNH8 KCNH3

7.23e-06294237516908
Pubmed

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts.

PIM3 PIM1

7.23e-06294226075720
Pubmed

Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control.

SCN11A GABRA2

7.23e-06294221632935
Pubmed

N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases.

UGT1A4 UGT1A3

7.23e-06294214570768
Pubmed

KSHV reactivation from latency requires Pim-1 and Pim-3 kinases to inactivate the latency-associated nuclear antigen LANA.

PIM3 PIM1

7.23e-06294219266083
Pubmed

Genome-wide association meta-analysis for total serum bilirubin levels.

UGT1A4 UGT1A3 UGT1A5

1.04e-051694319414484
Pubmed

Genome-wide association of serum bilirubin levels in Korean population.

UGT1A4 UGT1A3 UGT1A5

1.26e-051794320639394
Pubmed

A genome-wide assessment of variability in human serum metabolism.

UGT1A4 UGT1A3 UGT1A5

1.80e-051994323281178
Pubmed

Molecular oxygen sensing: implications for visceral surgery.

EGLN3 EGLN1

2.16e-05394222395314
Pubmed

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.

PIM3 PIM1

2.16e-05394219965690
Pubmed

Developmental expression of pim kinases suggests functions also outside of the hematopoietic system.

PIM3 PIM1

2.16e-05394210713710
Pubmed

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

EGLN3 EGLN1

2.16e-05394223690557
Pubmed

Systemic hypoxia mimicry enhances axonal regeneration and functional recovery following peripheral nerve injury.

EGLN3 EGLN1

2.16e-05394232814068
Pubmed

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer.

EGLN3 EGLN1

2.16e-05394236509284
Pubmed

Characterization and comparative analysis of the EGLN gene family.

EGLN3 EGLN1

2.16e-05394211574160
Pubmed

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.

EGLN3 EGLN1

2.16e-05394227561929
Pubmed

Preischemic targeting of HIF prolyl hydroxylation inhibits fibrosis associated with acute kidney injury.

EGLN3 EGLN1

2.16e-05394222262480
Pubmed

Loss of Prolyl-Hydroxylase 1 Protects against Biliary Fibrosis via Attenuated Activation of Hepatic Stellate Cells.

EGLN3 EGLN1

2.16e-05394230248340
Pubmed

The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.

PIM3 PIM1

2.16e-05394225238262
Pubmed

Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma.

PIM3 PIM1

2.16e-05394228698206
Pubmed

Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival.

EGLN3 EGLN1

2.16e-05394221887331
Pubmed

Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.

EGLN3 EGLN1

2.16e-05394224508125
Pubmed

The essential role of PIM kinases in sarcoma growth and bone invasion.

PIM3 PIM1

2.16e-05394222623646
Pubmed

PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation.

PIM3 PIM1

2.16e-05394231015445
Pubmed

EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes.

EGLN1 HELLS

2.16e-05394228900510
Pubmed

Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases.

PIM3 PIM1

2.16e-05394224916111
Pubmed

Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice.

PIM3 PIM1

2.16e-05394223360755
Pubmed

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases.

EGLN3 EGLN1

2.16e-05394227502280
Pubmed

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis.

EGLN3 EGLN1

2.16e-05394227981571
Pubmed

Analysis of HIF-prolyl hydroxylases binding to substrates.

EGLN3 EGLN1

2.16e-05394217069766
Pubmed

Isolation and characterization of a UDP-glucuronosyltransferase (UGT1A01) cloned from female rhesus monkey.

UGT1A3 UGT1A5

2.16e-05394212051676
Pubmed

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

EGLN3 EGLN1

2.16e-05394222343896
Pubmed

Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer.

EGLN3 EGLN1

2.16e-05394224195777
Pubmed

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.

EGLN3 EGLN1

2.16e-05394220959442
Pubmed

Spatiotemporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis.

GABRD GABRA2

2.16e-05394221722213
Pubmed

PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity.

PIM3 PIM1

2.16e-05394229781812
Pubmed

Distribution and functional properties of human KCNH8 (Elk1) potassium channels.

KCNH8 KCNH3

2.16e-05394212890647
Pubmed

PI3K-like kinases restrain Pim gene expression in endothelial cells.

PIM3 PIM1

2.16e-05394222282239
Pubmed

Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic stem cells.

PIM3 PIM1

2.16e-05394223495171
Pubmed

Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene.

PIM3 PIM1

2.16e-05394218042805
Pubmed

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation.

EGLN3 EGLN1

2.16e-05394212234095
Pubmed

Role of the intracellular localization of HIF-prolyl hydroxylases.

EGLN3 EGLN1

2.16e-05394219339211
Pubmed

TOP2A, HELLS, ATAD2, and TET3 Are Novel Prognostic Markers in Renal Cell Carcinoma.

TOP2A HELLS

2.16e-05394228069330
Pubmed

Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population.

GABRP GABRA2

2.16e-05394229135068
Pubmed

Patterns and Significance of PIM Kinases in Urothelial Carcinoma.

PIM3 PIM1

2.16e-05394226551340
Pubmed

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.

EGLN3 EGLN1

2.16e-05394226774962
Pubmed

Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes.

EGLN3 EGLN1

2.16e-05394224037093
Pubmed

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

EGLN3 EGLN1

2.16e-05394211595184
Pubmed

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

EGLN3 EGLN1

2.16e-05394211595178
Pubmed

Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients.

EGLN3 EGLN1

2.16e-05394221877141
Pubmed

High Expression of NEK2 and PIM1, but Not PIM3, Is Linked to an Aggressive Phenotype of Bronchopulmonary Neuroendocrine Neoplasms.

PIM3 PIM1

2.16e-05394232504181
Pubmed

Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737.

PIM3 PIM1

2.16e-05394222080570
Pubmed

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates.

EGLN3 EGLN1

2.16e-05394231500697
Pubmed

Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: relationship between maturation and apoptotic sensitivity.

EGLN3 EGLN1

2.16e-05394217044072
Pubmed

Improved vascular survival and growth in the mouse model of hindlimb ischemia by a remote signaling mechanism.

EGLN3 EGLN1

2.16e-05394224440788
Pubmed

Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2.

EGLN3 EGLN1

2.16e-05394228418093
Pubmed

PIM kinases: an overview in tumors and recent advances in pancreatic cancer.

PIM3 PIM1

2.16e-05394224799066
Pubmed

Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.

PIM3 PIM1

2.16e-05394223209281
Pubmed

PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.

EGLN3 EGLN1

2.16e-05394226075818
Pubmed

Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.

EGLN3 EGLN1

2.16e-05394222786772
Pubmed

PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection.

PIM1 GBP1

2.16e-05394237797010
Pubmed

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors.

PIM3 PIM1

2.16e-05394215199164
Pubmed

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.

EGLN3 EGLN1

2.16e-05394212615973
Pubmed

Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages.

EGLN3 EGLN1

2.16e-05394228716863
Pubmed

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

EGLN3 EGLN1

2.16e-05394218063574
Pubmed

PIM kinases as therapeutic targets against advanced melanoma.

PIM3 PIM1

2.16e-05394227448973
Pubmed

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.

EGLN3 EGLN1

2.16e-05394222615432
Pubmed

Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery.

EGLN3 EGLN1

2.16e-05394233819286
Pubmed

Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors.

PIM3 PIM1

2.16e-05394220939820
Pubmed

Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.

UGT1A4 UGT1A3

2.16e-05394223611809
Pubmed

Prolyl hydroxylase domain proteins regulate bone mass through their expression in osteoblasts.

EGLN3 EGLN1

2.16e-05394227614241
Pubmed

Genetic polymorphisms of SLC28A3, SLC29A1 and RRM1 predict clinical outcome in patients with metastatic breast cancer receiving gemcitabine plus paclitaxel chemotherapy.

SLC28A3 RRM1

2.16e-05394224361227
Pubmed

A role for UDP-glucose glycoprotein glucosyltransferase in expression and quality control of MHC class I molecules.

UGT1A3 UGT1A5

2.16e-05394221383159
Pubmed

HIF prolyl hydroxylase 2/3 deletion disrupts astrocytic integrity and exacerbates neuroinflammation.

EGLN3 EGLN1

2.16e-05394237140003
Pubmed

Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function.

EGLN3 EGLN1

2.16e-05394220600011
Pubmed

Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampus.

GABRD GABRP GABRA2

2.45e-052194325708312
Cytoband2q37

UGT1A4 UGT1A3 UGT1A5

3.58e-05319432q37
Cytoband9q22.2

SLC28A3 CTSV

5.53e-04179429q22.2
Cytoband3p22.2

SCN11A XIRP1

1.11e-03249423p22.2
GeneFamilyGamma-aminobutyric acid type A receptor subunits

GABRD GABRP GABRA2

4.72e-0519683563
GeneFamilyUDP glucuronosyltransferases

UGT1A4 UGT1A3 UGT1A5

2.33e-0432683363
GeneFamilyPotassium voltage-gated channels

KCNH8 KCNG1 KCNH3

4.55e-0440683274
GeneFamilyTubulin tyrosine ligase family

TTLL11 TTLL8

1.23e-0314682779
ToppCellfacs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RANBP17 ERCC6 KCNG1 NUP210L SLC13A2 HELLS

1.55e-06170936d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCellwk_15-18-Epithelial-PNS-Schwann_precursor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

P2RY11 PLA2G4B RASGEF1C CTSV PRRT4 GABRA2

1.95e-061779365357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCellSevere_COVID-19-Myeloid-proliferating_Myeloid_cells|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

AZU1 RRM1 GPAT2 PRRT4 TOP2A HELLS

3.22e-061939360d85025690c9cd545cba30abc38acbdd6a39b153
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AZU1 RRM1 GPAT2 PRRT4 TOP2A HELLS

3.32e-06194936cb39850e9577015b6b9834e98c36b412bae7d462
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AZU1 RRM1 GPAT2 PRRT4 TOP2A HELLS

3.32e-06194936408597c9aa302a44b112c1d612c21fbb0227a82a
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

AZU1 RRM1 GPAT2 PRRT4 TOP2A HELLS

3.32e-06194936193cc20fefbd795a4ad59e401a95af47d30603e7
ToppCellBAL-Severe-Myeloid-Myeloid|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AZU1 RRM1 GPAT2 PRRT4 TOP2A HELLS

3.32e-061949362360b5f995b360419de41612368cab9fb61781a1
ToppCellBAL-Severe-Myeloid-Myeloid-proliferating_Myeloid_cells|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

AZU1 RRM1 GPAT2 PRRT4 TOP2A HELLS

3.32e-06194936903ae11708b0cb24538c6982abd57fe6fa95b8d3
ToppCellBAL-Severe-Myeloid-Myeloid|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

AZU1 RRM1 GPAT2 PRRT4 TOP2A HELLS

3.32e-0619493658406502a8cbcc3037f79a1b6a683df408297ae5
ToppCellcontrol-Myeloid-Immature_Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

AZU1 SLC28A3 RRM1 PRRT4 TOP2A HELLS

3.42e-06195936bfaceb0601cf3855f38d6e1f482f01ad03ef11fe
ToppCellmild-Myeloid-Immature_Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

AZU1 SLC28A3 RRM1 PRRT4 TOP2A HELLS

3.63e-06197936bd9d57e0c873f6526dca322f4dad8e6bd692586c
ToppCellsevere-Myeloid-Immature_Neutrophils_2|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

AZU1 SLC28A3 RRM1 PRRT4 TOP2A HELLS

3.73e-06198936e36303628af3139310c1d7a84d2919b7319bbda4
ToppCellmild-immature_Neutrophil|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ILK AZU1 PRRT4 DNAH1

2.77e-0583934f7225bc24ad6df3a41375cc4614af824e0db3559
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.4|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SCN11A KCNG1 CYP4B1 CDH7 PAQR7

2.80e-05169935d59c8cd0719ed0947d42da9e7e5da72ff58ecc0d
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Basal_1|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

TTLL11 AZU1 NBEA TOP2A HELLS

2.88e-05170935aabe993c9f337b1caaeb0e64626a3920579c41b7
ToppCellfacs-Heart-RV-24m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

3.69e-051799356aa211670e5d6e013d0980967aa0a4f8f2905efe
ToppCellfacs-Heart-RV-24m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

3.69e-05179935cf4d3828a3ce97932c68d06f5c65a070fc6d832c
ToppCellfacs-Heart-RV-24m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

3.69e-05179935f9bc76ff25f88ee44c72499a0df9dc16f519c4cb
ToppCellfacs-Heart-RV|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

4.32e-051859357cf2b0db059605032bfae60cf1b93c4c62608f0c
ToppCellsaliva-Severe-critical_progression_d28-40|saliva / Compartment, severity and other cell annotations on 10x 3' data (130k)

R3HDM4 CMTM2 ETS2 GBP1 IGSF9

4.43e-051869350095560ca776b01aa473ad4d6015ed78fc93ff51
ToppCell368C-Myeloid-Dendritic-cDC_proliferating_1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

XYLT2 GCFC2 ERCC6 GPAT2 TOP2A

4.43e-051869355cadab3271fce9ab6da3d7ba9827b8a221cac166
ToppCellfacs-Heart-RV-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

4.90e-0519093589d1d686cc683206534e2157554d7d0df5d53497
ToppCellfacs-Heart-RV-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

4.90e-0519093565ba6c4f4a2905c0bf4ff99518ae49e3dfd5e640
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

5.02e-051919355020fe6c3452e7fab57847f5043d28ebbc5aa381
ToppCellfacs-Heart-RV-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

5.02e-0519193584ebb9f8e975acc88aa600c08a8aa791256948a6
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

5.15e-0519293524d28e28a5c54ca7770f7e5ad7f4d00039e0aaf9
ToppCell(5)_Epi_upper|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

GABRP EGLN3 ATG9B PIM1 CTSV

5.15e-051929350c8f73cfd24531a040544df39f28626433aaa651
ToppCell(5)_Epithelial_cells-(5)_Epi_upper|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

GABRP EGLN3 ATG9B PIM1 CTSV

5.15e-0519293569b6b3ceaad6432c46d1bc2a00b8389069a8876e
ToppCellfacs-Heart-RA-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

5.28e-05193935e7805e866339f676e3f770980c2e0a649eff472e
ToppCellfacs-Heart-RA-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

5.28e-051939351ad941098f1a44a46c2f6ebff32a98ada32c80ab
ToppCellcontrol-Myeloid-Immature_Neutrophils_2|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

AZU1 SLC28A3 RRM1 PRRT4 TOP2A

5.28e-0519393533349830e9eba506470ad3661fad5e5a283d20ca
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIM3 EGLN3 TIE1 EGLN1 TOP2A

5.28e-05193935dd443b83d328a9069ffe19ac3d74066e922515a5
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GABRP EGLN3 SLC5A6 RRM1 HELLS

5.41e-051949350e9830ad070c47acaa952400bf2a3ddbff664a2f
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TIE1 CYP4B1 RRM1 TOP2A HELLS

5.41e-05194935ae6d5cf4c825b29e677296df2c0985431c83b82e
ToppCelldroplet-Lung-1m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADRB1 GRTP1 TIE1 CYP4B1 EHD2

5.41e-051949351ac52b00ea0b0ddbd04f5d85fa8c086980a78926
ToppCelldroplet-Lung-30m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADRB1 GRTP1 TIE1 CYP4B1 EHD2

5.41e-05194935fc3f81b5bdc544a69c355e482f002643e029a7b0
ToppCellfacs-Heart-RA-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2 EHD2

5.54e-05195935f4fdcc0b851392086e9618e76ee6a0b540d5fb3c
ToppCelldroplet-Marrow-BM-1m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTLL11 RRM1 TOP2A CHST3 EHD2

5.68e-05196935ef1482f83872af72a55b6c5b5a1491e6f7f44dd7
ToppCellsevere-Myeloid-Immature_Neutrophils_2|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

AZU1 SLC28A3 RRM1 PRRT4 TOP2A

5.96e-05198935844f534551483c89ef789d1cfeb4680e54f794b2
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

AZU1 PRRT4 TOP2A DARS2 DNAH1

6.10e-05199935c6d59ed26eadd3c41acfe1b4d929270e00ea3e95
ToppCellfacs-Lung-18m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADRB1 TIE1 CYP4B1 ETS2 EHD2

6.10e-05199935c11e0044d3cc37f6bb26df033ad4448b419addfc
ToppCellPBMC-Severe|PBMC / Compartment, Disease Groups and Clusters

PIM3 PIM1 ETS2 GBP1 HELLS

6.10e-05199935b428d95d3c90b28f658f652a768588a8ced4abd9
ToppCellLPS_IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

TIE1 ETS2 POPDC3 PLEC EHD2

6.25e-05200935b70b7adb7c187e6253c7f0bb4c1f09c85ef7142c
ToppCellControl_saline-Endothelial-Endothelial-Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

KL TIE1 ETS2 PLEC EHD2

6.25e-05200935abf4ba5fcb54cdeada0da1a8b956a30aa47679e4
ToppCellmild-immature_Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ILK AZU1 PRRT4 DNAH1

8.06e-051099342f03d6ee8b13424cc6a5bc60ac3461b44dff9d79
ToppCellTCGA-Stomach-Solid_Tissue_Normal-Stomach_normal_tissue-Stomach_normal_tissue-2|TCGA-Stomach / Sample_Type by Project: Shred V9

UGT1A4 UGT1A5 IGKV3D-7 FMO6P

1.33e-041249349d62f997a1a389386e8d83652bdf109c2a1c96d8
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-matrix_-_immature_4|E18.5-samps / Age Group, Lineage, Cell class and subclass

ERCC6 POPDC3 TOP2A HELLS

1.59e-04130934169d88bffd7cd813a484d809defa638ceaca4bcb
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

ADRB1 KCNG1 CDH7 GABRA2

2.29e-041439345fb5a4ea93e5cce55d427e3b4a50a979504fad3c
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nxph3-Excitatory_Neuron.Slc17a7-Slc17a6.Nxph3-Cbln2-Htr2c_(Deep_layer_subiculum)|Hippocampus / BrainAtlas - Mouse McCarroll V32

KCNH8 PLA2G4B GPAT2

2.31e-045793335494ca30bdafb4c175d74f0b4892098411784b0
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-liver_dendritic_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

METTL13 SLC46A3 OR2B6 CTSV

3.04e-04154934acfbde0fbc09fd69af62a81f8f63e14e36dd1ae0
ToppCellfacs-BAT-Fat-24m-Lymphocytic-NK_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

METTL13 PTPN9 PXYLP1 PAQR7

3.12e-04155934550e7e7e52829244ead829e5be010bfdc71e2ba5
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IGSF9 POPDC3 TOP2A HELLS

3.19e-041569348349604bd801e20d33770f7d8243598c3756302b
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM1 ETS2 SLC13A2 TOP2A

3.52e-04160934cfd005e98944817458e8ef9e0c436d77f50c1ad1
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRP EGLN3 SLC28A3 SLC13A2

3.69e-041629343a1cbfed5a063131d49e3c1584f62b12660ecb36
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRP EGLN3 SLC28A3 SLC13A2

3.69e-0416293404b3c38bb27fa369a9ac5b60883f8b058abc5180
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC28A3 POPDC3 CTSV MGAM2

3.77e-04163934a1fbefe53523a9879a4d4b493071059798b5f917
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

INTS5 RASGEF1C PHB2 TOP2A

3.77e-04163934360cd65decda24853124f33a174f5224d7f3ce23
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-like-AT1_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

INTS5 RASGEF1C PHB2 TOP2A

3.77e-04163934b59d9b4f7c9f4e5e2c7783a49a96729dae3a81e5
ToppCell5'-Airway_Nasal_SMG-Epithelial|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC28A3 POPDC3 CTSV MGAM2

3.77e-04163934454a5e87e2f9f66e38cc5aa1b433c47b54c9be42
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC28A3 POPDC3 CTSV MGAM2

3.77e-04163934d9bd9d90cfa4e85d5ea51f8f3ee14a700571f508
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC28A3 POPDC3 CTSV MGAM2

3.77e-04163934f6847f47a8856c0d4136c1af317432d45eccfde9
ToppCell5'-Airway_Nasal_SMG|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC28A3 POPDC3 CTSV MGAM2

3.77e-04163934d8450bf9c6d2ec5dd1472952c9e65f82f995337a
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC28A3 POPDC3 CTSV MGAM2

3.77e-04163934be6cc44df9a2b10dce1a353717c279c3558f8fec
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

METTL13 TIE1 EHD2 HELLS

3.95e-0416593462457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCellwk_20-22-Hematologic-Myeloid-GMP|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

AZU1 SLC28A3 URB2 HELLS

4.04e-04166934d96e88e73a40205f32cebd7e54ca1ff09ee1e7e8
ToppCellICU-NoSEP-Myeloid-cDC2|ICU-NoSEP / Disease, Lineage and Cell Type

EGLN3 ADRB1 ETS2 CTSV

4.13e-041679345b7b731944d888591279ef6167b3ae8cab3f6886
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATG9B RRM1 TOP2A HELLS

4.13e-04167934859dfe0764cb69de27e79e1c1aa65f9d538f79ea
ToppCelldroplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRB1 NUP210L TOP2A HELLS

4.13e-04167934bad33497ceeab968a7eb8a48b921c6f936390743
ToppCellPND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PIM1 RRM1 TOP2A HELLS

4.23e-04168934c09aa66fd1374ecc4b4d4b56600a6f04aafa5be9
ToppCellfacs-Heart-RV-24m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TIE1 CYP4B1 ETS2 DYRK4

4.23e-04168934831b000e26b4a7e7fdfa3988372e0281c45eadbb
ToppCell3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATG9B KL CYP46A1 MGAM2

4.23e-041689344e2e4c88ada772e9ba6e72c9ae3a05c063e93318
ToppCell3'-Adult-SmallIntestine-Epithelial-epithelial_progenitor_cell-TA|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATG9B KL CYP46A1 MGAM2

4.23e-04168934ee4dab089adef2f47a9d39d91934523331a8b81c
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DCDC1 RNF103 CYP46A1 DNAH1

4.32e-04169934fba841664939c771881ba97f14ef1df6635c04ff
ToppCellfacs|World / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TCAF1 CYP4B1 PLEC EHD2

4.52e-04171934bb71e816dde44fda6af0ad98d979be9f8740fda6
ToppCellfacs|World / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCAF1 CYP4B1 PLEC EHD2

4.52e-041719345bcb96ed7fc15548f2dc9cf47482f890640cb39c
ToppCelldroplet-Kidney-KIDNEY-1m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCAF1 GCFC2 ADRB1 IGSF9

4.52e-04171934d9ad6a3bce3556abd24af1630bf4a99594437c3a
ToppCellEndothelial-B-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

GABRD EGLN3 SCN11A CYP46A1

4.62e-04172934d4e98ff9c7cbc95457e1d71fa60f151a2f178dae
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP1 PLA2G4B TOP2A HELLS

4.72e-04173934a5172dee859bf6c2eed46c48bd64dfef0ff9f28f
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

XIRP1 PLA2G4B TOP2A HELLS

4.72e-04173934639b5b0b33ce5aa0bc26363c059717012ddc14c0
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Proliferating_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATG9B SLC46A3 DYRK4 GABRA2

4.72e-0417393415af4a0f7516dbf5c93ba66a19aca073ebe30d04
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

METTL13 URB2 TOP2A HELLS

4.83e-0417493472df66319f6efbd88ecf439013d97409fbf3cb52
ToppCellPND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

METTL13 URB2 TOP2A HELLS

4.83e-04174934c6087fd0e036ec7f40f0f8f17d1f6ce13ddb5235
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Enterocyte|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP4B1 IGSF9 PLEC SLC13A2

4.83e-041749342fbdb62e269acf4447b171700a615e878dde7f9f
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP4B1 IGSF9 PLEC SLC13A2

4.83e-041749347c52b5d8f1e65e5208c952be341fa155ed0e6e76
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal-Deuterosomal_L.0.3.4.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AZU1 NDUFAF3 TOP2A HELLS

4.83e-041749340227fea1678baa9168bd47c3b4aacb2592bb5867
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AZU1 NDUFAF3 TOP2A HELLS

4.83e-04174934c2f8c59fca5f1ff6ffa6dc8cfce62da4b19fe9b3
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Deuterosomal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

AZU1 NDUFAF3 TOP2A HELLS

4.83e-0417493484024c04b0ce9f7068677d2d99ede56882b7dbd2
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ADRB1 KCNG1 KCNH3 GABRA2

4.93e-04175934ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ADRB1 KCNG1 KCNH3 GABRA2

4.93e-0417593421f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCellAT1_cells-HP_01|World / lung cells shred on cell class, cell subclass, sample id

RANBP17 KDM5A CYP4B1 EHD2

5.04e-04176934458720776b0151cd55acc352d509599cb62f0ca8
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCN11A RRM1 TOP2A HELLS

5.15e-04177934f925a15d2162d166a5b60edac3517c6b2d6cfbea
ToppCellfacs-Aorta-Heart-24m-Endothelial-nan|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PIM3 TIE1 CYP4B1 ETS2

5.15e-04177934c6b955765aee8a196fcf4f7bb16139c95b76dc4e
ToppCellPND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PPP4R1 POPDC3 RRM1 TOP2A

5.15e-041779341d5a071157c755f3a27a5c3143015da04ee0b0dc
ToppCellIIH-CD8-antiviral_CD4|IIH / Condition, Cell_class and T cell subcluster

GPR137 ERCC6 P2RY11 PXYLP1

5.15e-04177934fe73608c40701eca88b260aeb5c0640d7bee72ba
ToppCellfacs-Lung-EPCAM-18m-Endothelial|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRB1 RHBDF2 TIE1 CYP4B1

5.15e-041779342433924dcb085ebbe2545d476ebd7ee68e6092fb
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIM3 KL TIE1 GABRA2

5.26e-04178934aa44851653d276226b922ee14dd1fc8d1a844cdf
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIM3 TIE1 RRM1 TOP2A

5.26e-04178934462111b61f37338f97ac7dc6c7da1d4316b54445
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PIM3 TIE1 NUP210L TOP2A

5.26e-04178934ea10117026021c959ffc871fc377cdb3e161d264
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNH8 RASGEF1C SLC28A3 FAN1

5.26e-04178934ef490b45901b2e6dedb519540fa3ae4e4db3a9ba
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATG9B DCDC1 KCNH3 DNAH1

5.26e-041789343b12db04006db6e94fc45649a4b3a63b92f21a61
ComputationalNeurotransmitter (GABA) receptor.

GABRD GABRP GABRA2

6.48e-0515583MODULE_215
Drug4-methylumbelliferyl glucuronide

UGT1A4 UGT1A3 KL UGT1A5 ABCC2

4.36e-0738925CID000091553
Drughexobarbital

UGT1A4 UGT1A3 GABRP CYP4B1 UGT1A5 CYP46A1 GABRA2

8.41e-07127927CID000003608
Drugalmokalant

UGT1A4 UGT1A3 PIM1 UGT1A5

9.24e-0719924CID003033962
Drugdiosmetin

UGT1A4 UGT1A3 CYP4B1 UGT1A5 ABCC2 CYP46A1

1.25e-0685926CID005281612
Drugestriol-16-glucuronide

UGT1A4 UGT1A3 UGT1A5 NDUFAF3

1.42e-0621924CID000122281
Drugcampestrol

UGT1A4 UGT1A3 UGT1A5 ABCC2 CYP46A1

1.60e-0649925CID000010134
DrugC2-MPAcid

UGT1A4 GMPS UGT1A3 UGT1A5 ABCC2

1.96e-0651925CID000508230
DrugFinrazole

UGT1A4 UGT1A3 GABRP UGT1A5 GABRA2

1.96e-0651925CID000178036
Drugphenobarbital

UGT1A4 GABRD UGT1A3 GABRP CYP4B1 UGT1A5 PLEC ABCC2 CYP46A1 GABRA2

1.97e-063609210CID000004763
Drugestradiol-3-glucuronide

UGT1A4 UGT1A3 UGT1A5 ABCC2

2.08e-0623924CID000066651
DrugAC1NQGK1

UGT1A4 UGT1A3 KL UGT1A5 ABCC2

2.16e-0652925CID005195977
DrugDB04103

UGT1A4 UGT1A3 EGLN3 UGT1A5 PLEC ABCC2

2.71e-0697926CID004469987
DrugSN-38G

UGT1A4 UGT1A3 KL UGT1A5 ABCC2

4.07e-0659925CID000443154
Drugerucin

UGT1A4 UGT1A3 UGT1A5 ABCC2

4.75e-0628924CID000078160
DrugAC1MRQNQ

UGT1A4 UGT1A3 UGT1A5

5.27e-069923CID003522271
DrugDHPASiU

UGT1A4 UGT1A3 UGT1A5

5.27e-069923CID000197602
Drug3-iodophenol

UGT1A4 UGT1A3 UGT1A5

5.27e-069923CID000012272
DrugAC1L4J7U

UGT1A4 UGT1A3 UGT1A5

5.27e-069923CID000186631
DrugChebi:32663

UGT1A4 UGT1A3 UGT1A5

5.27e-069923CID005460873
Drugtrans-3'-hydroxycotinine

UGT1A4 UGT1A3 KL UGT1A5

5.49e-0629924CID000000414
Drug3 -hydroxypregn-5-en-20-one

UGT1A4 UGT1A3 GABRP CYP4B1 UGT1A5 PLEC CYP46A1 GABRA2

5.54e-06238928CID000001027
DrugAC1L9E0Q

UGT1A4 UGT1A3 UGT1A5 ABCC2

6.31e-0630924CID000443095
Drugpregnenolone-16 alpha-carbonitrile

UGT1A4 UGT1A3 UGT1A5 PLEC ABCC2

7.65e-0667925CID000015032
DrugAC1Q7AUJ

UGT1A4 UGT1A3 CYP4B1 UGT1A5 PLEC CYP46A1

8.05e-06117926CID000003303
Drugindole-2-carboxylic acid

UGT1A4 UGT1A3 ADRB1 UGT1A5

8.23e-0632924CID000072899
DrugNNAL

UGT1A4 UGT1A3 UGT1A5 PLEC

8.23e-0632924CID000104856
DrugR(-)-Denopamine

UGT1A4 UGT1A3 ADRB1 UGT1A5

9.34e-0633924CID000003818
Drug4-nitrophenyl)imidazole

UGT1A4 UGT1A3 UGT1A5

1.03e-0511923CID000123155
DrugAC1O5XMV

UGT1A4 UGT1A3 UGT1A5

1.03e-0511923CID006442661
DrugPhIP-HCl

UGT1A4 UGT1A3 CYP4B1 PIM1 UGT1A5 ABCC2

1.07e-05123926CID000001530
Drugeugenol

UGT1A4 UGT1A3 UGT1A5 AZU1 ABCC2

1.17e-0573925CID000003314
Drug2,2,2-trichloroethanol

UGT1A4 UGT1A3 CYP4B1 UGT1A5 TAAR8

1.17e-0573925CID000008259
DrugAC1NOWCJ

UGT1A4 UGT1A3 KL UGT1A5

1.19e-0535924CID005120112
Drug3-[(3S,5R,10S,13R,14S,17R)-3-[(2S,4R,5R,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

UGT1A4 UGT1A3 UGT1A5 PLEC

1.19e-0535924CID010436171
Drugmuraglitazar

UGT1A4 UGT1A3 ADRB1 UGT1A5

1.33e-0536924CID000206044
DrugN-OH-DABZ

UGT1A4 UGT1A3 UGT1A5

1.37e-0512923CID000051366
Drug1-O-beta-D-glucopyranosyl-D-mannitol

UGT1A4 UGT1A3 UGT1A5

1.37e-0512923CID000088735
Drug2,4,6-TCB

UGT1A4 UGT1A3 UGT1A5

1.37e-0512923CID000037247
Drugnonanoyl-N-methylglucamide

UGT1A4 UGT1A3 UGT1A5

1.37e-0512923CID000160090
Drug7,7,7-triphenylheptanoic acid

UGT1A4 UGT1A3 UGT1A5

1.37e-0512923CID000276709
DrugDoxepin hydrochloride [1229-29-4]; Up 200; 12.6uM; MCF7; HT_HG-U133A

GPR137 GRTP1 KDM5A PIM1 DNAJC16 POPDC3 OR2B6

1.54e-051979277415_UP
DrugSulfachloropyridazine [80-32-0]; Down 200; 14uM; MCF7; HT_HG-U133A

GPR137 KCNG1 CYP4B1 FAXDC2 POPDC3 ABCC2 OR2B6

1.59e-051989273944_DN
DrugMyosmine [532-12-7]; Down 200; 27.4uM; MCF7; HT_HG-U133A

GPR137 XYLT2 ERCC6 CRADD KDM5A KCNG1 ABCC2

1.59e-051989274759_DN
Drugafloqualone

UGT1A4 UGT1A3

1.62e-052922ctd:C033541
Drugtritanol

UGT1A4 UGT1A3 UGT1A5

1.77e-0513923CID000006457
Drug5-azido-UDP-glucuronic acid

UGT1A4 UGT1A3 UGT1A5

1.77e-0513923CID003081279
Drugcotinine-N-glucuronide

UGT1A4 UGT1A3 UGT1A5

1.77e-0513923CID000000411
Drugmetaclazepam

GABRP ADRB1 GABRA2

1.77e-0513923CID000071272
Drugharmol

UGT1A4 UGT1A3 UGT1A5 ABCC2

2.04e-0540924CID000068094
Drugphenylbutazone

UGT1A4 UGT1A3 KL UGT1A5 ABCC2

2.19e-0583925CID000004781
Drugpropranolol glucuronide

UGT1A4 UGT1A3 UGT1A5

2.25e-0514923CID000119515
DrugPCB-61

UGT1A4 UGT1A3 UGT1A5

2.25e-0514923CID000036401
DrugAC1Q6O8B

UGT1A4 UGT1A3 UGT1A5 ABCC2

2.25e-0541924CID000000334
Drug2,2',3,5,5'-pentachlorobiphenyl

UGT1A4 UGT1A3 UGT1A5

2.80e-0515923CID000040469
Drugafloqualone

UGT1A4 UGT1A3 UGT1A5

2.80e-0515923CID000002040
Drugnaphthyl sulphate

UGT1A4 UGT1A3 UGT1A5

2.80e-0515923CID000114775
Drugcoumarin-3-carboxylic acid

UGT1A4 UGT1A3 UGT1A5

2.80e-0515923CID000010752
Drugsulforaphane nitrile

UGT1A4 UGT1A3 UGT1A5

2.80e-0515923CID000543743
Drugquercetin-3,4'-diglucoside

UGT1A4 UGT1A3 UGT1A5

3.44e-0516923CID005320835
Drug1'-hydroxyestragole

UGT1A4 UGT1A3 UGT1A5

3.44e-0516923CID000040003
Drugbilirubin-phosphate

UGT1A4 UGT1A3 UGT1A5

3.44e-0516923CID005497144
Drugthymol

GABRD GABRP GCFC2 GABRA2

3.58e-0546924CID000006989
Drug3 beta,5 alpha,25R)- 3-hydroxyspirostan-12-one

UGT1A4 UGT1A3 UGT1A5

4.17e-0517923CID000003573
Drug6-hydroxychrysene

UGT1A4 UGT1A3 UGT1A5

4.17e-0517923CID000037766
Drugdihydroxyaflavinine

GABRD GABRP GABRA2

4.17e-0517923CID000156857
Drug1-hydroxypyrene

UGT1A4 UGT1A3 KL UGT1A5

4.24e-0548924CID000021387
Drugsalicylamide

UGT1A4 UGT1A3 ADRB1 UGT1A5

4.24e-0548924CID000005147
DrugAC1L1G0K

UGT1A4 UGT1A3 ATP2C1 UGT1A5

4.60e-0549924CID000003473
DrugUDP - Na

UGT1A4 UGT1A3 XYLT2 P2RY11 UGT1A5 ABCC2 RRM1

4.75e-05235927CID000001158
DrugC11866

EGLN3 EGLN1

4.83e-053922CID000443459
DrugAC1LCF1F

UGT1A4 UGT1A3 KL UGT1A5 NDUFAF3 ABCC2

4.92e-05161926CID000627275
DrugSureCN12722713

UGT1A4 UGT1A3 UGT1A5

4.99e-0518923CID005488034
Drugethyl-beta-D-6-glucosiduronic acid

UGT1A4 UGT1A3 UGT1A5

4.99e-0518923CID000152226
DrugBr 2

UGT1A4 UGT1A3 UGT1A5

4.99e-0518923CID003060900
Drug2,3,7-trichlorodibenzo-p-dioxin

UGT1A4 UGT1A3 UGT1A5

4.99e-0518923CID000036614
DrugApApG

UGT1A4 UGT1A3 UGT1A5

4.99e-0518923CID003081975
DrugC1 11-32

UGT1A4 UGT1A3 UGT1A5

4.99e-0518923CID000443077
DrugC11131

UGT1A4 UGT1A3 UGT1A5

4.99e-0518923CID000443076
Drug9-OH-risperidone

UGT1A4 UGT1A3 UGT1A5

5.90e-0519923CID000475100
Drug5alpha-spirostan-3beta-ol

UGT1A4 UGT1A3 UGT1A5

5.90e-0519923CID000091433
DrugDEPC

UGT1A4 UGT1A3 UGT1A5 SLC13A2

6.28e-0553924CID000015357
DrugHCG 004

UGT1A4 UGT1A3 UGT1A5 ABCC2

6.76e-0554924CID000064928
Drugtangeretin

UGT1A4 UGT1A3 UGT1A5 ABCC2

6.76e-0554924CID000068077
Drugaminopyrine

UGT1A4 UGT1A3 CYP4B1 UGT1A5 PLEC CYP46A1

6.87e-05171926CID000006009
Drugglucosiduronate

UGT1A4 UGT1A3 KL UGT1A5 ABCC2 CHST3

6.87e-05171926CID000000610
Drugtectochrysin

UGT1A4 UGT1A3 UGT1A5

6.92e-0520923CID005281954
DrugAC1L1OBF

UGT1A4 UGT1A3 UGT1A5

6.92e-0520923CID000032736
Drug4'-hydroxydiclofenac

UGT1A4 UGT1A3 UGT1A5

6.92e-0520923CID000116545
Drugdulcin

UGT1A4 UGT1A3 UGT1A5

8.06e-0521923CID000009013
DrugBenzamidoxime hydrochloride

UGT1A4 UGT1A3 UGT1A5

8.06e-0521923CID000069186
Drugphenolphthalein

UGT1A4 UGT1A3 KL UGT1A5

8.96e-0558924CID000004764
Drugamonafide

UGT1A4 UGT1A3 UGT1A5

9.30e-0522923CID000050515
DrugN-methylpiperazine

UGT1A4 UGT1A3 UGT1A5

9.30e-0522923CID000053167
DrugMethotrexate [59-05-2]; Down 200; 8.8uM; MCF7; HT_HG-U133A

EGLN3 INTS5 GRTP1 RHBDF2 URGCP TOP2A

9.40e-051819265419_DN
Drugurochloralic acid

UGT1A4 UGT1A3 UGT1A5 PAQR7

9.59e-0559924CID003036914
Drugacetaminophen glucuronide

UGT1A4 UGT1A3 UGT1A5 ABCC2

9.59e-0559924CID000083944
DrugUDP-alpha-d-xylopyranose

UGT1A4 UGT1A3 XYLT2 UGT1A5

1.02e-0460924CID000001165
Drug5 beta-pregnanediol

GABRD GABRP ABCC2 GABRA2

1.02e-0460924CID000012547
Drugamidoxime

UGT1A4 UGT1A3 UGT1A5

1.07e-0423923CID000465967
Drugphenanthridine

UGT1A4 UGT1A3 UGT1A5

1.07e-0423923CID000009189
DiseaseX-11793--oxidized bilirubin measurement

UGT1A4 UGT1A3 UGT1A5

1.68e-068933EFO_0021260
DiseaseSuccinimide measurement

UGT1A4 UGT1A3 UGT1A5

1.68e-068933EFO_0022118
DiseaseX-11530 measurement

UGT1A4 UGT1A3 UGT1A5

1.68e-068933EFO_0021249
Diseasesulfate of piperine metabolite C16H19NO3 (2) measurement

UGT1A4 UGT1A3 UGT1A5

1.68e-068933EFO_0801034
Diseasecholelithiasis, bilirubin measurement

UGT1A4 UGT1A3 UGT1A5

1.68e-068933EFO_0004570, EFO_0004799
DiseaseX-11522 measurement

UGT1A4 UGT1A3 UGT1A5

1.68e-068933EFO_0800696
DiseaseX-10458 measurement

UGT1A4 UGT1A3 UGT1A5

1.68e-068933EFO_0800692
DiseaseX-24849 measurement

UGT1A4 UGT1A3 UGT1A5

1.68e-068933EFO_0800909
Diseasemembrane-associated progesterone receptor component 1 measurement

UGT1A4 UGT1A3 UGT1A5

1.68e-068933EFO_0802740
DiseaseX-16946 measurement

UGT1A4 UGT1A3 UGT1A5

1.68e-068933EFO_0800766
DiseaseX-11442 measurement

UGT1A4 UGT1A3 UGT1A5

2.51e-069933EFO_0021236
DiseaseX-11441 measurement

UGT1A4 UGT1A3 UGT1A5

2.51e-069933EFO_0021235
Diseasecirculating cell free DNA measurement

UGT1A4 UGT1A3 UGT1A5

2.51e-069933EFO_0004739
Diseasesulfate of piperine metabolite C18H21NO3 (3) measurement

UGT1A4 UGT1A3 UGT1A5

2.51e-069933EFO_0801037
Diseasetestis-specific chromodomain protein Y 1 measurement

UGT1A4 UGT1A3 UGT1A5

2.51e-069933EFO_0802127
Diseasesulfate of piperine metabolite C18H21NO3 (1) measurement

UGT1A4 UGT1A3 UGT1A5

2.51e-069933EFO_0801036
DiseaseX-11880 measurement

UGT1A4 UGT1A3 UGT1A5

2.51e-069933EFO_0800698
Diseasebilirubin measurement, response to xenobiotic stimulus

UGT1A4 UGT1A3 UGT1A5

2.51e-069933EFO_0004570, GO_0009410
Diseaseprotein-tyrosine kinase 6 measurement

UGT1A4 UGT1A3 UGT1A5

2.51e-069933EFO_0020691
DiseaseX-21448 measurement

UGT1A4 UGT1A3 UGT1A5

3.58e-0610933EFO_0800816
DiseaseUDP-glucuronosyltransferase 1-6 measurement

UGT1A4 UGT1A3 UGT1A5

3.58e-0610933EFO_0802185
DiseaseX-23974 measurement

UGT1A4 UGT1A3 UGT1A5

3.58e-0610933EFO_0800867
Diseasebilirubin measurement, response to tenofovir

UGT1A4 UGT1A3 UGT1A5

3.58e-0610933EFO_0004570, EFO_0009279
DiseaseX-21796 measurement

UGT1A4 UGT1A3 UGT1A5

4.91e-0611933EFO_0800825
Diseaseinsomnia, bilirubin measurement

UGT1A4 UGT1A3 UGT1A5

4.91e-0611933EFO_0004570, EFO_0004698
Diseasehistidine betaine (hercynine) measurement

UGT1A4 UGT1A3 UGT1A5

4.91e-0611933EFO_0800972
Diseasealdosterone measurement

UGT1A4 UGT1A3 UGT1A5

4.91e-0611933EFO_0010219
Diseasebiliverdin measurement

UGT1A4 UGT1A3 UGT1A5

6.53e-0612933EFO_0021033
Diseasep-cresol glucuronide measurement

UGT1A4 UGT1A3 UGT1A5

6.53e-0612933EFO_0800079
Diseaseretinol dehydrogenase 16 measurement

UGT1A4 UGT1A3 UGT1A5

8.47e-0613933EFO_0802007
DiseaseX-21441 measurement

UGT1A4 UGT1A5 ABCC2

2.00e-0517933EFO_0800814
Diseaselow density lipoprotein cholesterol measurement, body fat percentage

UGT1A4 UGT1A3 UGT1A5

2.00e-0517933EFO_0004611, EFO_0007800
Diseaseangiopoietin-related protein 1 measurement

UGT1A4 UGT1A3 UGT1A5

2.39e-0518933EFO_0801382
Diseasetissue factor measurement

UGT1A4 UGT1A3 UGT1A5

3.87e-0521933EFO_0010623
DiseasePremature aging syndrome

KL ERCC6

5.87e-054932C0231341
Diseasexanthurenate measurement

UGT1A4 UGT1A3 UGT1A5

1.04e-0429933EFO_0010551
Diseaseresponse to dolutegravir

UGT1A4 UGT1A3 UGT1A5

1.16e-0430933EFO_0600017
Diseasemolar-incisor hypomineralization

KCNG1 SLC28A3

3.49e-049932EFO_0005321
Diseasepregnenetriol sulfate measurement

UGT1A4 UGT1A5

5.31e-0411932EFO_0800586
Diseaseplasma N-desmethylclozapine measurement

UGT1A4 UGT1A5

5.31e-0411932EFO_0600039
Diseasepregnenetriol disulfate measurement

UGT1A4 UGT1A5

7.49e-0413932EFO_0800587
Diseaseserum metabolite measurement

UGT1A4 UGT1A3 CYP4B1 DNAJC16 UGT1A5 SLC5A6 GBP1 SLC28A3 ABCC2 FMO6P

7.93e-049459310EFO_0005653
Diseaseurate measurement, spine bone mineral density

UGT1A4 UGT1A3 UGT1A5

8.25e-0458933EFO_0004531, EFO_0007701
Diseasesleep measurement

DNAJC16 RASGEF1C SLC28A3 URB2

8.93e-04135934EFO_0004870
DiseaseAdrenocortical carcinoma

RRM1 TOP2A

1.45e-0318932C0206686
Diseasedilated cardiomyopathy (implicated_via_orthology)

ADRB1 ILK CTSV

2.09e-0380933DOID:12930 (implicated_via_orthology)
Diseasethyroxine measurement

UGT1A4 UGT1A3 UGT1A5

2.32e-0383933EFO_0005130
Diseasehormone measurement

UGT1A4 UGT1A3 UGT1A5

2.40e-0384933EFO_0004730
Diseasecholelithiasis

UGT1A4 UGT1A3 UGT1A5

2.74e-0388933EFO_0004799

Protein segments in the cluster

PeptideGeneStartEntry
RPVEPLDLAVFWVEF

UGT1A3

451

P35503
DPAWLEFLQVIGTFL

URB2

991

Q14146
RELVPDRLFVFFNWL

ADRB1

351

P08588
VDIIPGFEFDRWLNT

RNPEP

471

Q9H4A4
FREPLFLDLPKSVDW

CTSV

106

O60911
PESEWPFLIITDLFL

ATXN10

211

Q9UBB4
FPAVLRWFAERVDLI

EHD2

171

Q9NZN4
FVEDLGFWRVLLLIF

ANKRD46

186

Q86W74
ADVEPIFDRLLFFWS

EGLN3

176

Q9H6Z9
NLRELWSLFDFIFPG

ERCC6

681

Q03468
LFVFWRELRDNVITP

ATP2C1

791

P98194
QLFQGFRDLLWLPIE

ATG2A

1756

Q2TAZ0
ETWEERLLRFFSVSP

R3HDM4

191

Q96D70
WRTIFLEPETLDLFF

RANBP17

251

Q9H2T7
FDEIILFSLPPALDW

PTPN9

261

P43378
WFLLDVIAALPFDLL

KCNH3

306

Q9ULD8
PIFTLRDLVLWALDE

DCDC1

1461

M0R2J8
EFILLGFSDRPWLEF

OR2B6

11

P58173
LLRLALFVETVDFWG

PAQR7

86

Q86WK9
FQGDFLWPILVVEFL

P2RY11

26

Q96G91
SELWSLLNFLLPDVF

HELLS

391

Q9NRZ9
SVWRFLRDLELEIPF

nan

1156

O00370
ISPFSLPFWERLLLD

MED13L

1396

Q71F56
RWSIPTILEFNLFGI

MGAM2

586

Q2M2H8
FFLLLLWLPDTTGEI

IGKV3D-7

11

A0A0C4DH55
FVWELLPTTLLVGFF

GPR137

281

Q96N19
QFLLFVFLVWDPARL

GABRA2

11

P47869
WRLLGDLLPEAVRFF

IRF2BPL

471

Q9H1B7
EFILLGFFGRWELQI

OR4L1

11

Q8NH43
RFLELAPDFVGDILW

ETS2

146

P15036
LTDELAPVFLLRWFY

DNAJC16

501

Q9Y2G8
PDFVWTLRDFSLDLE

GBP1

176

P32455
LDSRFVDKLWLPDTF

GABRD

111

O14764
SIFFLWRELGPSVLA

ABCC2

451

Q92887
WLFLTDPRLALEVYF

FMO6P

456

O60774
VGWFSLEFLLRLIQA

KCNG1

276

Q9UIX4
GRIAEFFTDLLTWRP

PLA2G4B

551

P0C869
DTILAEGLHFRIPWF

PHB2

61

Q99623
WEEFTDPLSFIGRIR

KDM5A

26

P29375
LSRIVELIEPWFIFS

DNAH1

2096

Q9P2D7
TSFLDFLRRCLVWEP

DYRK4

371

Q9NR20
RLLTTFEGKEWILFF

FAXDC2

66

Q96IV6
DEPDWESLIFLARLI

GMPS

536

P49915
PAWGTFRLLEEETLI

CYP46A1

366

Q9Y6A2
RLTDFVEFLWDPLST

GCFC2

561

P16383
SRWFICLFVDILPVE

GRTP1

231

Q5TC63
TFLDSLQEFPWVREK

CRADD

71

P78560
LLWELVTREVPFADL

ILK

381

Q13418
FSWLTEEILLRGFDV

GPAT2

481

Q6NUI2
LLFWFRPRALEIIDF

ATG9B

641

Q674R7
IEPKFDRLLFFWSDR

EGLN1

356

Q9GZT9
RVLEFDIGWLAEPIF

KL

751

Q9UEF7
DFFLQWIGRGLLVLE

CYP4B1

116

P13584
IPDNVIFREFIWERL

CDH7

701

Q9ULB5
AIFIIPQGRETEWLF

METTL13

301

Q8N6R0
PDFFTRVALFRDWID

AZU1

226

P20160
PDLFLERLAFPDLWL

RNF103

486

O00237
FVILVLLWFTREPGF

SLC13A2

336

Q13183
FPLQFLDSPEWDSLR

POPDC3

176

Q9HBV1
TLDARLVEFLWVPDT

GABRP

106

O00591
PWILEPSRFFLELNA

NUP210L

681

Q5VU65
LDPSNVIFLRWDFDL

MOXD2P

36

A6NHM9
LLDWFERPDSFVLIL

PIM1

106

P11309
EDLPLFLRCFTVGWI

FAN1

651

Q9Y2M0
RGVVLRDPTLFSFLW

DARS2

466

Q6PI48
RDPTLFSFLWVVDFP

DARS2

471

Q6PI48
FHFWRTPLPEIDLDI

PPP4R1

456

Q8TF05
GWVLIDFLLFFIPTL

TAAR8

196

Q969N4
LQEAFGWEPFIRLFT

TCAF1

836

Q9Y4C2
DLIRPWFPEFSEARA

SLC5A6

381

Q9Y289
LSWLVRIEPFTTFFL

NBEA

2386

Q8NFP9
IRELGFEWSFLIIAV

SLC46A3

191

Q7Z3Q1
FPRFAARLIFELWQD

PXYLP1

396

Q8TE99
LLILRTDPGFIAFDW

SLC28A3

241

Q9HAS3
PFEVRLLLLSVWGFL

INTS5

936

Q6P9B9
LFEPLWHIERTVSFE

CHST3

161

Q7LGC8
PFILWPISDLFNDLI

CMTM2

141

Q8TAZ6
FLFRDSWEQTLPDGL

C11orf53

101

Q8IXP5
LVEISWFFPSGREDL

URGCP

311

Q8TCY9
PRSWILPDEFQLFVA

TTLL11

306

Q8NHH1
ADFVLGRDFRPWLIE

TTLL8

526

A6PVC2
DITEDSFSLFWLLEP

NDUFAF3

96

Q9BU61
SFSLFWLLEPRIEIV

NDUFAF3

101

Q9BU61
EEQRARDLFFALWIP

RRM1

321

P23921
FEVPRLVLADSGFWE

TIE1

411

P35590
LQLLAEWTETFPRDF

RASGEF1C

111

Q8N431
RPVEPLDLAVFWVEF

UGT1A5

451

P35504
RPLFFLTLEADWAEA

PRRT4

341

C9JH25
VIRLLDWFERPDGFL

PIM3

106

Q86V86
DWFERPDGFLLVLER

PIM3

111

Q86V86
ERRFPSSFEEIEILW

PLEC

441

Q15149
EWLRFGFLLPIFIQF

IGSF9

56

Q9P2J2
WPSLLRHRFLEEFIT

TOP2A

561

P11388
RGFILDEFSFLRDPW

SCN11A

181

Q9UI33
LFVELFQSWPLLERP

RHBDF2

731

Q6PJF5
TLWLFETKPLDAFRD

XIRP1

381

Q702N8
LLQFWEPLGETRFLV

XYLT2

731

Q9H1B5
RPVEPLDLAVFWVEF

UGT1A4

451

P22310
TWFIIDLIAALPFDL

KCNH8

301

Q96L42