Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	1-phosphatidylinositol-4-phosphate 3-kinase activity	PIK3C2A PIK3C2G PIK3CB	4.33e-06	7	101	3	GO:0035005
GeneOntologyMolecularFunction	1-phosphatidylinositol-3-kinase activity	PIK3C2A PIK3C2G PIK3CB	2.01e-05	11	101	3	GO:0016303
GeneOntologyMolecularFunction	microtubule motor activity	DNAH10 KIF1A KIF1B DNAH2 DNAH5	2.79e-05	70	101	5	GO:0003777
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNAH10 KIF1A KIF1B DNAH2 DNAH5 KLC1	3.01e-05	118	101	6	GO:0003774
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH10 DNAH2 DNAH5	9.70e-05	18	101	3	GO:0008569
GeneOntologyMolecularFunction	cytoskeletal protein binding	RAD51D FLII KIF1A STRBP SPTB KIF1B WHAMM KATNA1 NOD2 SYNE3 DLC1 ALMS1 CTNNA2 RAB27A KLC1 TBCD	1.23e-04	1099	101	16	GO:0008092
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIK3C2A PIK3C2G PIK3CB	3.00e-04	26	101	3	GO:0052742
GeneOntologyMolecularFunction	tubulin binding	RAD51D KIF1A STRBP KIF1B WHAMM KATNA1 ALMS1 KLC1 TBCD	3.22e-04	428	101	9	GO:0015631
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH10 DNAH2 DNAH5	3.75e-04	28	101	3	GO:0051959
GeneOntologyMolecularFunction	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PIK3C2A PIK3CB	5.23e-04	7	101	2	GO:0046934
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH10 DNAH2 DNAH5	8.61e-04	37	101	3	GO:0045505
GeneOntologyMolecularFunction	G protein-coupled glutamate receptor activity	GRM3 GRM7	8.91e-04	9	101	2	GO:0098988
GeneOntologyMolecularFunction	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	GRM3 GRM7	8.91e-04	9	101	2	GO:0001640
GeneOntologyMolecularFunction	lipid kinase activity	PIK3C2A PIK3C2G PIK3CB	1.16e-03	41	101	3	GO:0001727
GeneOntologyMolecularFunction	type II transforming growth factor beta receptor binding	TGFB3 BAMBI	1.62e-03	12	101	2	GO:0005114
GeneOntologyMolecularFunction	JUN kinase kinase kinase activity	MAP3K12 MAP3K13	1.62e-03	12	101	2	GO:0004706
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	GRM7 RYR1 CATSPER2	1.63e-03	46	101	3	GO:0005245
GeneOntologyMolecularFunction	ATP hydrolysis activity	RAD51D DNAH10 KIF1A ERCC6L KIF1B DNAH2 KATNA1 DNAH5	1.79e-03	441	101	8	GO:0016887
GeneOntologyCellularComponent	microtubule associated complex	DNAH10 KIF1A KIF1B DNAH2 KATNA1 DNAH5 KLC1	1.41e-05	161	102	7	GO:0005875
GeneOntologyCellularComponent	9+2 motile cilium	DNAH10 DNAH2 QRICH2 AKAP4 CATSPER2 SLC22A14 DNAH5	1.67e-04	238	102	7	GO:0097729
GeneOntologyCellularComponent	axonemal dynein complex	DNAH10 DNAH2 DNAH5	2.40e-04	25	102	3	GO:0005858
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex	PIK3C2A PIK3C2G PIK3CB	3.76e-04	29	102	3	GO:0005942
GeneOntologyCellularComponent	axon	PDE2A CAD ROGDI KIF1A KIF1B KATNA1 GRM3 GRM7 SYAP1 MAP3K12 NGDN CTNNA2 KLC1	3.93e-04	891	102	13	GO:0030424
GeneOntologyCellularComponent	supramolecular fiber	CAB39 DNAH10 KIF1A KRT74 KIF1B DNAH2 WHAMM KATNA1 RYR1 AKAP4 DLC1 KRT71 DNAH5 KLC1 TBCD	5.85e-04	1179	102	15	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	CAB39 DNAH10 KIF1A KRT74 KIF1B DNAH2 WHAMM KATNA1 RYR1 AKAP4 DLC1 KRT71 DNAH5 KLC1 TBCD	6.27e-04	1187	102	15	GO:0099081
GeneOntologyCellularComponent	extrinsic component of membrane	RYR1 NOD2 PIK3C2A PIK3C2G PIK3CB CTNNA2	9.29e-04	230	102	6	GO:0019898
GeneOntologyCellularComponent	inner dynein arm	DNAH10 DNAH2	1.03e-03	10	102	2	GO:0036156
GeneOntologyCellularComponent	microtubule	DNAH10 KIF1A KIF1B DNAH2 WHAMM KATNA1 DNAH5 KLC1 TBCD	1.19e-03	533	102	9	GO:0005874
GeneOntologyCellularComponent	transferase complex, transferring phosphorus-containing groups	CAB39 RB1CC1 TRRAP AKAP4 PIK3C2A PIK3C2G PIK3CB	1.28e-03	335	102	7	GO:0061695
GeneOntologyCellularComponent	cilium	NPR2 DNAH10 PKD1L1 DNAH2 QRICH2 AKAP4 ALMS1 CATSPER2 SLC22A14 DNAH5 RAB27A KLC1	1.42e-03	898	102	12	GO:0005929
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	DNAH10 KIF1A KRT74 KIF1B DNAH2 WHAMM KATNA1 DLC1 KRT71 DNAH5 KLC1 TBCD	1.43e-03	899	102	12	GO:0099513
GeneOntologyCellularComponent	kinesin complex	KIF1A KIF1B KLC1	1.77e-03	49	102	3	GO:0005871
GeneOntologyCellularComponent	Swr1 complex	EP400 TRRAP	1.78e-03	13	102	2	GO:0000812
GeneOntologyCellularComponent	motile cilium	DNAH10 DNAH2 QRICH2 AKAP4 CATSPER2 SLC22A14 DNAH5	1.78e-03	355	102	7	GO:0031514
GeneOntologyCellularComponent	cytoplasmic region	DNAH10 KIF1A KIF1B DNAH2 PPFIA3 CTNNA2 DNAH5	1.93e-03	360	102	7	GO:0099568
GeneOntologyCellularComponent	cell cortex	SPTB PPFIA3 GRM7 RYR1 NEDD4 DLC1 CTNNA2	2.29e-03	371	102	7	GO:0005938
GeneOntologyCellularComponent	dynein complex	DNAH10 DNAH2 DNAH5	2.34e-03	54	102	3	GO:0030286
GeneOntologyCellularComponent	somatodendritic compartment	PDE2A CAD ROGDI KIF1A KIF1B KATNA1 GRM3 GRM7 SYAP1 NEDD4 NGDN TGFB3 RAB27A KLC1	2.53e-03	1228	102	14	GO:0036477
Domain	ARM-type_fold	CAB39 USP34 UBR4 USP24 NBEA MEI1 TRRAP PIK3C2A PIK3C2G PIK3CB ELMO2 CTNNBL1 RIC8A LRBA HECTD1 TBCD	4.51e-11	339	102	16	IPR016024
Domain	-	TRRAP PIK3C2A PIK3C2G PIK3CB	1.45e-06	16	102	4	1.10.1070.11
Domain	PI3Kc	TRRAP PIK3C2A PIK3C2G PIK3CB	1.45e-06	16	102	4	SM00146
Domain	ARM-like	CAB39 NBEA MEI1 TRRAP ELMO2 CTNNBL1 RIC8A LRBA HECTD1 TBCD	2.23e-06	270	102	10	IPR011989
Domain	PI3_PI4_kinase	TRRAP PIK3C2A PIK3C2G PIK3CB	2.42e-06	18	102	4	PF00454
Domain	PI3_4_KINASE_1	TRRAP PIK3C2A PIK3C2G PIK3CB	2.42e-06	18	102	4	PS00915
Domain	PI3_4_KINASE_2	TRRAP PIK3C2A PIK3C2G PIK3CB	2.42e-06	18	102	4	PS00916
Domain	PI3/4_kinase_cat_dom	TRRAP PIK3C2A PIK3C2G PIK3CB	2.42e-06	18	102	4	IPR000403
Domain	PI3_4_KINASE_3	TRRAP PIK3C2A PIK3C2G PIK3CB	2.42e-06	18	102	4	PS50290
Domain	PI3K_Ras-bd_dom	PIK3C2A PIK3C2G PIK3CB	5.45e-06	7	102	3	IPR000341
Domain	PI3K_rbd	PIK3C2A PIK3C2G PIK3CB	5.45e-06	7	102	3	SM00144
Domain	PI3K_rbd	PIK3C2A PIK3C2G PIK3CB	5.45e-06	7	102	3	PF00794
Domain	PI3K_RBD	PIK3C2A PIK3C2G PIK3CB	5.45e-06	7	102	3	PS51546
Domain	DHC_N1	DNAH10 DNAH2 DNAH5	8.68e-06	8	102	3	PF08385
Domain	PI3K_C2	PIK3C2A PIK3C2G PIK3CB	8.68e-06	8	102	3	SM00142
Domain	PI3K_C2_dom	PIK3C2A PIK3C2G PIK3CB	8.68e-06	8	102	3	IPR002420
Domain	PI3K_C2	PIK3C2A PIK3C2G PIK3CB	8.68e-06	8	102	3	PF00792
Domain	PI3K_C2	PIK3C2A PIK3C2G PIK3CB	8.68e-06	8	102	3	PS51547
Domain	Dynein_heavy_dom-1	DNAH10 DNAH2 DNAH5	8.68e-06	8	102	3	IPR013594
Domain	PI3Ka	PIK3C2A PIK3C2G PIK3CB	1.30e-05	9	102	3	PF00613
Domain	PI3Ka	PIK3C2A PIK3C2G PIK3CB	1.30e-05	9	102	3	SM00145
Domain	-	PIK3C2A PIK3C2G PIK3CB	1.30e-05	9	102	3	1.25.40.70
Domain	PI_Kinase	PIK3C2A PIK3C2G PIK3CB	1.85e-05	10	102	3	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2A PIK3C2G PIK3CB	1.85e-05	10	102	3	IPR001263
Domain	PIK_HELICAL	PIK3C2A PIK3C2G PIK3CB	1.85e-05	10	102	3	PS51545
Domain	-	CAB39 TRRAP ELMO2 CTNNBL1 RIC8A LRBA HECTD1 TBCD	2.95e-05	222	102	8	1.25.10.10
Domain	DUF1088	NBEA LRBA	2.95e-05	2	102	2	IPR010508
Domain	MAP3K12_MAP3K13	MAP3K12 MAP3K13	2.95e-05	2	102	2	IPR017419
Domain	DUF1088	NBEA LRBA	2.95e-05	2	102	2	PF06469
Domain	Dynein_heavy_chain_D4_dom	DNAH10 DNAH2 DNAH5	5.51e-05	14	102	3	IPR024317
Domain	Dynein_HC_stalk	DNAH10 DNAH2 DNAH5	5.51e-05	14	102	3	IPR024743
Domain	Dynein_heavy_dom-2	DNAH10 DNAH2 DNAH5	5.51e-05	14	102	3	IPR013602
Domain	DHC_N2	DNAH10 DNAH2 DNAH5	5.51e-05	14	102	3	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH10 DNAH2 DNAH5	5.51e-05	14	102	3	IPR011704
Domain	MT	DNAH10 DNAH2 DNAH5	5.51e-05	14	102	3	PF12777
Domain	AAA_8	DNAH10 DNAH2 DNAH5	5.51e-05	14	102	3	PF12780
Domain	AAA_5	DNAH10 DNAH2 DNAH5	5.51e-05	14	102	3	PF07728
Domain	DHC_fam	DNAH10 DNAH2 DNAH5	6.86e-05	15	102	3	IPR026983
Domain	Dynein_heavy	DNAH10 DNAH2 DNAH5	6.86e-05	15	102	3	PF03028
Domain	PI3/4_kinase_CS	PIK3C2A PIK3C2G PIK3CB	6.86e-05	15	102	3	IPR018936
Domain	Dynein_heavy_dom	DNAH10 DNAH2 DNAH5	6.86e-05	15	102	3	IPR004273
Domain	SUZ	ARPP21 R3HDM1	8.83e-05	3	102	2	PF12752
Domain	Kinesin-like_KIF1-typ	KIF1A KIF1B	1.76e-04	4	102	2	IPR022140
Domain	SUZ	ARPP21 R3HDM1	1.76e-04	4	102	2	IPR024771
Domain	KIF1B	KIF1A KIF1B	1.76e-04	4	102	2	PF12423
Domain	SUZ	ARPP21 R3HDM1	1.76e-04	4	102	2	PS51673
Domain	TPR_REGION	DNAH10 ERCC6L DNAH2 MAU2 INTS8 KLC1	2.90e-04	165	102	6	PS50293
Domain	TPR	DNAH10 ERCC6L DNAH2 MAU2 INTS8 KLC1	2.90e-04	165	102	6	PS50005
Domain	DUF4704	NBEA LRBA	2.92e-04	5	102	2	IPR031570
Domain	DUF4704	NBEA LRBA	2.92e-04	5	102	2	PF15787
Domain	Kinesin_assoc	KIF1A KIF1B	4.37e-04	6	102	2	PF16183
Domain	PH_BEACH	NBEA LRBA	4.37e-04	6	102	2	PF14844
Domain	Kinesin-like	KIF1A KIF1B	4.37e-04	6	102	2	IPR022164
Domain	Kinesin_assoc	KIF1A KIF1B	4.37e-04	6	102	2	IPR032405
Domain	DUF3694	KIF1A KIF1B	4.37e-04	6	102	2	PF12473
Domain	P-loop_NTPase	RAD51D EP400 DNAH10 KIF1A ERCC6L KIF1B DNAH2 KATNA1 NOD2 GBP4 CHST4 DNAH5 RAB27A	7.08e-04	848	102	13	IPR027417
Domain	GPCR_3_mtglu_rcpt	GRM3 GRM7	8.09e-04	8	102	2	IPR000162
Domain	PH-BEACH_dom	NBEA LRBA	8.09e-04	8	102	2	IPR023362
Domain	-	NBEA LRBA	8.09e-04	8	102	2	2.30.29.40
Domain	PH_BEACH	NBEA LRBA	8.09e-04	8	102	2	PS51783
Domain	BEACH	NBEA LRBA	1.04e-03	9	102	2	PS50197
Domain	Beach	NBEA LRBA	1.04e-03	9	102	2	PF02138
Domain	-	NBEA LRBA	1.04e-03	9	102	2	1.10.1540.10
Domain	Beach	NBEA LRBA	1.04e-03	9	102	2	SM01026
Domain	R3H	ARPP21 R3HDM1	1.04e-03	9	102	2	SM00393
Domain	BEACH_dom	NBEA LRBA	1.04e-03	9	102	2	IPR000409
Domain	ANF_lig-bd_rcpt	NPR2 GRM3 GRM7	1.07e-03	37	102	3	IPR001828
Domain	ANF_receptor	NPR2 GRM3 GRM7	1.07e-03	37	102	3	PF01094
Domain	AAA	RAD51D DNAH10 DNAH2 KATNA1 DNAH5	1.16e-03	144	102	5	SM00382
Domain	AAA+_ATPase	RAD51D DNAH10 DNAH2 KATNA1 DNAH5	1.16e-03	144	102	5	IPR003593
Domain	Peripla_BP_I	NPR2 GRM3 GRM7	1.25e-03	39	102	3	IPR028082
Domain	R3H	ARPP21 R3HDM1	1.57e-03	11	102	2	PS51061
Domain	R3H	ARPP21 R3HDM1	1.57e-03	11	102	2	PF01424
Domain	-	ARPP21 R3HDM1	1.57e-03	11	102	2	3.30.1370.50
Domain	R3H_dom	ARPP21 R3HDM1	1.57e-03	11	102	2	IPR001374
Domain	NCD3G	GRM3 GRM7	2.22e-03	13	102	2	PF07562
Domain	GPCR_3_9-Cys_dom	GRM3 GRM7	2.22e-03	13	102	2	IPR011500
Domain	-	RAD51D EP400 DNAH10 ERCC6L DNAH2 KATNA1 NOD2 GBP4 CHST4 DNAH5 RAB27A	2.51e-03	746	102	11	3.40.50.300
Domain	VitD_rcpt	NR1I2 NR1I3	2.57e-03	14	102	2	IPR000324
Domain	GPCR_3_CS	GRM3 GRM7	2.57e-03	14	102	2	IPR017979
Domain	Ubiquitin-rel_dom	USP24 PIK3C2A PIK3C2G PIK3CB RASSF4	3.39e-03	184	102	5	IPR029071
Domain	-	GATAD2B NR1I2 NR1I3	3.74e-03	57	102	3	3.30.50.10
Domain	Znf_NHR/GATA	GATAD2B NR1I2 NR1I3	3.92e-03	58	102	3	IPR013088
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 FLII PDE2A EP400 UBR4 TRRAP RYR1 KIAA2013 ANO8 NOD2 SYNE3 BAMBI DEPDC5 RIC8A LRBA HECTD1 TBCD	3.10e-08	1105	104	17	35748872
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 FLII PDE2A KIF1A SPTB KIF1B UBR4 WHAMM NBEA SEC31B INTS8 TMEM168 MIGA1 LRBA R3HDM1 HECTD1 MGAT5B PLXNB3	4.80e-08	1285	104	18	35914814
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ERCC6L ORC3 STRBP UBR4 USP24 DNAH2 NBEA PPFIA3 SEC31B RYR1 NGDN CCDC102B	4.88e-07	638	104	12	31182584
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE2A PIK3C2A PIK3C2G PIK3CB	1.26e-06	27	104	4	11156964
Pubmed	The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.	PIK3C2A PIK3C2G PIK3CB	3.07e-06	10	104	3	8636073
Pubmed	Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.	PIK3C2A PIK3C2G PIK3CB	3.07e-06	10	104	3	8798481
Pubmed	Expression of HIV-1 nef decreases basal phosphatidyl-inositol 3-kinase activity.	PIK3C2A PIK3C2G PIK3CB	3.07e-06	10	104	3	9247029
Pubmed	The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts.	ARPP21 RPS6KA5 R3HDM1	4.21e-06	11	104	3	29581509
Pubmed	HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.	PIK3C2A PIK3C2G PIK3CB	4.21e-06	11	104	3	16081599
Pubmed	HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.	PIK3C2A PIK3C2G PIK3CB	4.21e-06	11	104	3	9708406
Pubmed	HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line.	PIK3C2A PIK3C2G PIK3CB	4.21e-06	11	104	3	10985305
Pubmed	Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells.	PIK3C2A PIK3C2G PIK3CB	4.21e-06	11	104	3	12584329
Pubmed	Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.	PIK3C2A PIK3C2G PIK3CB	4.21e-06	11	104	3	9808187
Pubmed	Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.	PIK3C2A PIK3C2G PIK3CB	5.60e-06	12	104	3	14602571
Pubmed	Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells.	PIK3C2A PIK3C2G PIK3CB	5.60e-06	12	104	3	16514418
Pubmed	HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.	PIK3C2A PIK3C2G PIK3CB	5.60e-06	12	104	3	10208934
Pubmed	Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.	PIK3C2A PIK3C2G PIK3CB	5.60e-06	12	104	3	12077252
Pubmed	Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.	PIK3C2A PIK3C2G PIK3CB	5.60e-06	12	104	3	9341793
Pubmed	Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.	KIF1A KIF1B KLC1	5.60e-06	12	104	3	16301330
Pubmed	Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.	PIK3C2A PIK3C2G PIK3CB	5.60e-06	12	104	3	12551992
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	UBR4 NBEA RB1CC1 ELMO2 TBCD	6.60e-06	87	104	5	12465718
Pubmed	HIV-1 Nef in macrophage-mediated disease pathogenesis.	PIK3C2A PIK3C2G PIK3CB	7.27e-06	13	104	3	23215766
Pubmed	Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.	PIK3C2A PIK3C2G PIK3CB	7.27e-06	13	104	3	9394803
Pubmed	Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR.	NR1I2 NR1I3	8.86e-06	2	104	2	22698814
Pubmed	Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals.	NR1I2 NR1I3	8.86e-06	2	104	2	34504302
Pubmed	Analysis of common polymorphisms within NR1I2 and NR1I3 genes and tacrolimus dose-adjusted concentration in stable kidney transplant recipients.	NR1I2 NR1I3	8.86e-06	2	104	2	28777242
Pubmed	Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3).	NR1I2 NR1I3	8.86e-06	2	104	2	20185760
Pubmed	Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity.	NR1I2 NR1I3	8.86e-06	2	104	2	30778091
Pubmed	Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver.	NR1I2 NR1I3	8.86e-06	2	104	2	30593543
Pubmed	Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis.	CELA3B CELA3A	8.86e-06	2	104	2	27999401
Pubmed	Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line.	NR1I2 NR1I3	8.86e-06	2	104	2	21628639
Pubmed	A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification.	NR1I2 NR1I3	8.86e-06	2	104	2	14742670
Pubmed	The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors.	KIF1A KIF1B	8.86e-06	2	104	2	7539720
Pubmed	Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury.	NR1I2 NR1I3	8.86e-06	2	104	2	15684063
Pubmed	Polymorphisms in regulators of xenobiotic transport and metabolism genes PXR and CAR do not affect multiple myeloma risk: a case-control study in the context of the IMMEnSE consortium.	NR1I2 NR1I3	8.86e-06	2	104	2	23303387
Pubmed	Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR.	NR1I2 NR1I3	8.86e-06	2	104	2	11114890
Pubmed	Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.	NR1I2 NR1I3	8.86e-06	2	104	2	35212371
Pubmed	The roles of nuclear receptors CAR and PXR in hepatic energy metabolism.	NR1I2 NR1I3	8.86e-06	2	104	2	18305370
Pubmed	Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability.	NR1I2 NR1I3	8.86e-06	2	104	2	29199543
Pubmed	CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR).	NR1I2 NR1I3	8.86e-06	2	104	2	11005856
Pubmed	Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR.	NR1I2 NR1I3	8.86e-06	2	104	2	27197997
Pubmed	Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.	NR1I2 NR1I3	8.86e-06	2	104	2	24690595
Pubmed	Expression of hepatic cytochrome P450s and UDP-glucuronosyltransferases in PXR and CAR double humanized mice treated with rifampicin.	NR1I2 NR1I3	8.86e-06	2	104	2	25835148
Pubmed	Activation of pregnane X receptor disrupts glucocorticoid and mineralocorticoid homeostasis.	NR1I2 NR1I3	8.86e-06	2	104	2	16973756
Pubmed	Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain.	MAP3K12 MAP3K13	8.86e-06	2	104	2	9353328
Pubmed	A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.	NR1I2 NR1I3	8.86e-06	2	104	2	18677425
Pubmed	Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.	NR1I2 NR1I3	8.86e-06	2	104	2	26363009
Pubmed	The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity.	NR1I2 NR1I3	8.86e-06	2	104	2	15358766
Pubmed	Regulation of CAR and PXR Expression in Health and Disease.	NR1I2 NR1I3	8.86e-06	2	104	2	33142929
Pubmed	Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.	NR1I2 NR1I3	8.86e-06	2	104	2	20403969
Pubmed	Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice.	NR1I2 NR1I3	8.86e-06	2	104	2	15619241
Pubmed	Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice.	NR1I2 NR1I3	8.86e-06	2	104	2	34971590
Pubmed	Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.	MAP3K12 MAP3K13	8.86e-06	2	104	2	27511108
Pubmed	Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response.	NR1I2 NR1I3	8.86e-06	2	104	2	12054576
Pubmed	In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets.	NR1I2 NR1I3	8.86e-06	2	104	2	30102401
Pubmed	Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development.	QRICH2 AKAP4	8.86e-06	2	104	2	34415320
Pubmed	RNA-Seq reveals common and unique PXR- and CAR-target gene signatures in the mouse liver transcriptome.	NR1I2 NR1I3	8.86e-06	2	104	2	27113289
Pubmed	Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.	NR1I2 NR1I3	8.86e-06	2	104	2	24863967
Pubmed	Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice.	MAP3K12 MAP3K13	8.86e-06	2	104	2	19358824
Pubmed	Polychlorinated Biphenyl-Xenobiotic Nuclear Receptor Interactions Regulate Energy Metabolism, Behavior, and Inflammation in Non-alcoholic-Steatohepatitis.	NR1I2 NR1I3	8.86e-06	2	104	2	26612838
Pubmed	Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver.	NR1I2 NR1I3	8.86e-06	2	104	2	21826054
Pubmed	Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes.	NR1I2 NR1I3	8.86e-06	2	104	2	19489075
Pubmed	Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.	CELA3B CELA3A	8.86e-06	2	104	2	2826474
Pubmed	Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression.	NR1I2 NR1I3	8.86e-06	2	104	2	28756207
Pubmed	Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes.	CELA3B CELA3A	8.86e-06	2	104	2	2460440
Pubmed	Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling.	UBR4 STAT2	8.86e-06	2	104	2	23555265
Pubmed	Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels.	NR1I2 NR1I3	8.86e-06	2	104	2	12485946
Pubmed	Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development.	NR1I2 NR1I3	8.86e-06	2	104	2	35184041
Pubmed	Suppression of Hepatic CYP3A4 Expression and Activity by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice.	NR1I2 NR1I3	8.86e-06	2	104	2	30573465
Pubmed	Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.	PIK3C2A PIK3C2G PIK3CB	9.23e-06	14	104	3	17157319
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH10 DNAH2 DNAH5	9.23e-06	14	104	3	9373155
Pubmed	HIV Nef enhances Tat-mediated viral transcription through a hnRNP-K-nucleated signaling complex.	PIK3C2A PIK3C2G PIK3CB	1.15e-05	15	104	3	18854243
Pubmed	Hdac6 regulates Tip60-p400 function in stem cells.	FLII EP400 TRRAP STAT2	1.33e-05	48	104	4	24302573
Pubmed	HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.	PIK3C2A PIK3C2G PIK3CB	1.41e-05	16	104	3	16524887
Pubmed	HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway.	PIK3C2A PIK3C2G PIK3CB	1.41e-05	16	104	3	11289809
Pubmed	Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice.	PIK3C2A PIK3C2G PIK3CB	1.41e-05	16	104	3	20019835
Pubmed	Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.	PIK3C2A PIK3C2G PIK3CB	1.41e-05	16	104	3	21029719
Pubmed	Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders.	PIK3C2A PIK3C2G PIK3CB	1.41e-05	16	104	3	20818790
Pubmed	Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes.	PIK3C2A PIK3C2G PIK3CB	1.71e-05	17	104	3	23251686
Pubmed	Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.	PIK3C2A PIK3C2G PIK3CB	1.71e-05	17	104	3	12960231
Pubmed	Signaling mechanism of HIV-1 gp120 and virion-induced IL-1beta release in primary human macrophages.	PIK3C2A PIK3C2G PIK3CB	1.71e-05	17	104	3	18453587
Pubmed	HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.	PIK3C2A PIK3C2G PIK3CB	2.05e-05	18	104	3	12526811
Pubmed	HIV-1 Tat protein induces the production of IDO in human monocyte derived-dendritic cells through a direct mechanism: effect on T cells proliferation.	PIK3C2A PIK3C2G PIK3CB	2.43e-05	19	104	3	24073214
Pubmed	Roles of xenobiotic receptors in vascular pathophysiology.	NR1I2 NR1I3	2.65e-05	3	104	2	24859622
Pubmed	Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice.	NR1I2 NR1I3	2.65e-05	3	104	2	22371261
Pubmed	The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.	NBEA LRBA	2.65e-05	3	104	2	28814779
Pubmed	BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks.	KIF1A KIF1B	2.65e-05	3	104	2	27851960
Pubmed	Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.	NR1I2 NR1I3	2.65e-05	3	104	2	26994748
Pubmed	The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor.	NR1I2 NR1I3	2.65e-05	3	104	2	19542321
Pubmed	Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.	NR1I2 NR1I3	2.65e-05	3	104	2	18187584
Pubmed	Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.	NR1I2 NR1I3	2.65e-05	3	104	2	15340055
Pubmed	Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.	NR1I2 NR1I3	2.65e-05	3	104	2	19034627
Pubmed	Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.	NR1I2 NR1I3	2.65e-05	3	104	2	12923173
Pubmed	PXR, CAR and HNF4alpha genotypes and their association with pharmacokinetics and pharmacodynamics of docetaxel and doxorubicin in Asian patients.	NR1I2 NR1I3	2.65e-05	3	104	2	17876342
Pubmed	Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway.	NR1I2 NR1I3	2.65e-05	3	104	2	18778245
Pubmed	Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.	KIF1A KLC1	2.65e-05	3	104	2	11144355
Pubmed	Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region.	WHAMMP3 WHAMM	2.65e-05	3	104	2	18226259
Pubmed	Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells.	NR1I2 NR1I3	2.65e-05	3	104	2	21517853
Pubmed	Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.	NR1I2 NR1I3	2.65e-05	3	104	2	23626729
Pubmed	Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes.	NR1I2 NR1I3	2.65e-05	3	104	2	22093699
Interaction	FHIP2A interactions	KIF1B WHAMMP3 NBEA LRBA KLC1	9.82e-06	56	103	5	int:FHIP2A
Interaction	CRYL1 interactions	FLII UBR4 ALMS1 PIK3C2A TBCD	9.82e-06	56	103	5	int:CRYL1
Interaction	ERMAP interactions	USP34 NADK2 UBR4 ELMO2	1.20e-05	28	103	4	int:ERMAP
Cytoband	2p22.2	VIT QPCT	5.23e-04	15	104	2	2p22.2
Cytoband	3q27	THPO MAP3K13	1.47e-03	25	104	2	3q27
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	KRT74 OR6C74 MAP3K12 STAT2 KRT71	2.83e-03	423	104	5	chr12q13
Cytoband	1p36.12	CELA3B CELA3A	3.57e-03	39	104	2	1p36.12
GeneFamily	Phosphatidylinositol 3-kinase subunits	PIK3C2A PIK3C2G PIK3CB	2.57e-06	8	66	3	831
GeneFamily	Dyneins, axonemal	DNAH10 DNAH2 DNAH5	3.05e-05	17	66	3	536
GeneFamily	Glutamate metabotropic receptors\|Protein phosphatase 1 regulatory subunits	GRM3 GRM7	3.62e-04	8	66	2	281
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LRBA	4.65e-04	9	66	2	1230
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K12 MAP3K13	3.44e-03	24	66	2	654
GeneFamily	Keratins, type II	KRT74 KRT71	4.34e-03	27	66	2	609
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	NBEA AKAP4	5.00e-03	29	66	2	396
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-2\|TCGA-Skin / Sample_Type by Project: Shred V9	RPS6KA5 EPG5 PIK3CB MIGA1 LRBA MGAT5B RAB27A	2.17e-07	181	103	7	9d5b331cabc5524f0a9fd8b571e87be4c447c7d4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A NEDD4 GBP4 PIK3C2A MMRN2 TBCD	6.01e-06	194	103	6	ad6c04ad0621689e3bf4c94ccd6e60653bbd02c7
ToppCell	COVID-19-kidney-Technical/muscle_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	KRT74 GRM3 GRM7 RYR1 CTNNA2	1.80e-05	139	103	5	64c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARPP21 DNAH10 NBEA SYCP2 PLXNB3	3.53e-05	160	103	5	f2cdee5a9e3b0eb125d6be7b5d239eb04333ae41
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NADK2 SPTB SEC31B GRM7 LRBA	3.53e-05	160	103	5	8374ae912337947b2cc8d17d5840f306361fe1ff
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NADK2 NEDD4 NOD2 GBP4 LRRC37B	4.09e-05	165	103	5	436ce4bc75e1ba4351c439ccad19f84ad5bcb92f
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NADK2 NEDD4 NOD2 GBP4 LRRC37B	4.09e-05	165	103	5	242bdb7654f415391fb8e9bdc06412c7eee9c97e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DNAH2 NBEA GRM7 DNAH5	4.58e-05	169	103	5	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KIF1A KRT74 CELA3B CELA3A QPCT	6.34e-05	181	103	5	cb17c904ab86d56dd30cac9b61acbb3b76f84ded
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARPP21 GRM7 R3HDM1 DNAH5 MGAT5B	6.51e-05	182	103	5	14a117c5e50db31ee1b2cf4df4d133451fd6d55f
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP34 USP24 RB1CC1 EPG5 LRBA	7.59e-05	188	103	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 STRBP RB1CC1 NEDD4 R3HDM1	8.18e-05	191	103	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 STRBP RB1CC1 NEDD4 R3HDM1	8.18e-05	191	103	5	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP34 STRBP RB1CC1 NEDD4 R3HDM1	8.18e-05	191	103	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	USP34 KIF1B PIK3C2A MIGA1 HECTD1	8.59e-05	193	103	5	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	CV-Severe-6\|Severe / Virus stimulation, Condition and Cluster	MARCHF9 STAT2 GBP4 RIC8A CCDC102B	8.80e-05	194	103	5	d33be6ed1de907aeea0c2dce09796556b8efdd4e
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DNAH10 DNAH2 NBEA GRM7 DNAH5	8.80e-05	194	103	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A NEDD4 GBP4 MMRN2 TBCD	8.80e-05	194	103	5	fa6d51f36a3dae8763a595c20892987ed454c0f0
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_plasma-B_plasmablast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARPP21 PSMD13 PPFIA3 MEI1 DEPDC5	9.01e-05	195	103	5	c6e31038be2463f1601d52c82efa4e9facb8228f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ARPP21 GRM7 CTNNA2 R3HDM1 MGAT5B	9.01e-05	195	103	5	787e95fb59c40bba784544b662fac37606ae1427
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A DLC1 GBP4 MMRN2 TBCD	9.23e-05	196	103	5	ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCell	Smart-seq2-thymus_(Smart-seq2)-lymphocytic-B_lymphocytic\|thymus_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SELENOT STRBP MEI1 PPIB QPCT	9.23e-05	196	103	5	60cde394db9f1c39c258c3e7c01d3d1c76cc49a1
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 USP24 CASP8 SEC31B LRBA	9.46e-05	197	103	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A DLC1 GBP4 PIK3C2A MMRN2	9.92e-05	199	103	5	14e09eaa2335d4503de50250eb4258dd5b85b304
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T\|COVID-19_Mild / Disease, condition lineage and cell class	USP24 SEC31B GBP4 LRBA RAB27A	9.92e-05	199	103	5	f307d4887b28cf60a591439e278fd668409cb104
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_\|World / Primary Cells by Cluster	ARPP21 KIF1A NBEA R3HDM1 KLC1	9.92e-05	199	103	5	058373b4ac3cec2108cb24265628ff0a50646e33
ToppCell	Neuronal-Excitatory-eC(RORB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRM3 GRM7 CTNNA2 RASSF4 MGAT5B	1.02e-04	200	103	5	8c803a0ce25e140b46036f6aabefc5502601f408
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Neuronal-Neurons\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	ARPP21 DNAH10 CTNNBL1 R3HDM1 KLC1	1.02e-04	200	103	5	b9538eb33ac86384e7e289a5a82fac4d56a7b9c2
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	DNAH2 MEI1 KIAA2013 DLC1 CCDC102B	1.02e-04	200	103	5	aafe594c88710f8c53d59667cdac5035e08f5511
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE2A DLC1 GBP4 PIK3C2A MMRN2	1.02e-04	200	103	5	3007583eaad3a5ae2df010513d3e4df59155123d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	DNAH2 MEI1 KIAA2013 DLC1 CCDC102B	1.02e-04	200	103	5	a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCell	control-HLA-DR-_S100A+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ROGDI NOD2 QPCT RASSF4 RAB27A	1.02e-04	200	103	5	9e3e13a68bc1110fa000ec2d80f4c654ddbce17e
Drug	1-methyl-2-phenylindole	NR1I2 NR1I3	2.07e-05	2	104	2	ctd:C520322
Drug	naphtholphthalein	NR1I2 NR1I3	2.07e-05	2	104	2	ctd:C002684
Drug	Trityl Compounds	NR1I2 NR1I3	2.07e-05	2	104	2	ctd:D014320
Drug	bis(2-propylheptyl)phthalate	NR1I2 NR1I3	2.07e-05	2	104	2	ctd:C000595304
Drug	Bromthymol Blue	NR1I2 NR1I3	2.07e-05	2	104	2	ctd:D001979
Drug	bupirimate	NR1I2 NR1I3	2.07e-05	2	104	2	ctd:C071704
Drug	Terphenyl Compounds	NR1I2 NR1I3	2.07e-05	2	104	2	ctd:D013730
Drug	tiracizine	NR1I2 NR1I3	2.07e-05	2	104	2	ctd:C048166
Drug	2-phenylindole	NR1I2 NR1I3	2.07e-05	2	104	2	ctd:C542223
Drug	thymol blue	NR1I2 NR1I3	2.07e-05	2	104	2	ctd:C013713
Drug	halenaquinone	PIK3C2A PIK3C2G PIK3CB	3.25e-05	14	104	3	CID000370346
Drug	Allantoin [97-59-6]; Up 200; 25.2uM; PC3; HT_HG-U133A	SPTB GRM3 DLC1 ALMS1 CATSPER2 DEPDC5 R3HDM1	3.30e-05	196	104	7	5052_UP
Drug	Sisomicin sulfate [53179-09-2]; Up 200; 2.8uM; PC3; HT_HG-U133A	RAD51D PDE2A CASP8 GRM7 STAT2 SYCP2 DLC1	3.41e-05	197	104	7	4014_UP
Drug	Tridihexethyl chloride; Down 200; 11.4uM; MCF7; HT_HG-U133A	KIF1A PPFIA3 DLC1 ELMO2 QPCT RAB27A TBCD	3.53e-05	198	104	7	5486_DN
Drug	CHEMBL459685	CASP8 PIK3C2A PIK3C2G PIK3CB	4.02e-05	42	104	4	CID010995375
Drug	4-hydroxyisoleucine	PIK3C2A PIK3C2G PIK3CB	4.05e-05	15	104	3	CID000354197
Drug	D-N-Q	FLII GRM3 GRM7 MAP3K12 MAP3K13	4.18e-05	84	104	5	CID000003140
Drug	cryptotanshinone	NR1I2 PIK3C2A PIK3C2G PIK3CB	4.42e-05	43	104	4	CID000160254
Drug	N-methyl-DL-aspartic acid	FLII PDE2A NPR2 CASP8 GRM3 GRM7 RYR1 PIK3C2A PIK3C2G PIK3CB BAMBI LRBA	4.49e-05	655	104	12	CID000004376
Drug	ZSTK474	PIK3C2A PIK3C2G PIK3CB	6.01e-05	17	104	3	CID011647372
Drug	androst-16-en-3-ol	NR1I2 NR1I3	6.18e-05	3	104	2	ctd:C003530
Drug	N-(2-(3-chloro-5-(trifluoromethyl)-2-pyridyl)ethyl)-alpha,alpha,alpha-trifluoro-o-toluamide	NR1I2 NR1I3	6.18e-05	3	104	2	ctd:C572868
Drug	Diphenylamine	GRM3 NR1I2	6.18e-05	3	104	2	ctd:D004159
Drug	tetrahydrofuran	NR1I2 NR1I3	6.18e-05	3	104	2	ctd:C018674
Drug	2-hydroxyheptanal	THPO LRBA	6.18e-05	3	104	2	CID000161209
Drug	Thymolphthalein	NR1I2 NR1I3	6.18e-05	3	104	2	ctd:D013944
Drug	NVP-BEZ235	PIK3C2A PIK3C2G PIK3CB	7.19e-05	18	104	3	CID011977753
Drug	vanadyl	PDE2A DNAH10 RPS6KA5 PIK3C2A PIK3C2G PIK3CB LRBA DNAH5	8.38e-05	307	104	8	CID000061671
Drug	Anidulafungin	PDE2A GRM3 GRM7 PIK3C2A PIK3C2G PIK3CB	8.49e-05	157	104	6	CID000166548
Drug	8-bromoguanosine 3',5'-cyclic monophosphate	PDE2A NPR2 RYR1 PIK3C2A PIK3C2G PIK3CB BAMBI LRBA	8.57e-05	308	104	8	CID000001915
Drug	PX-866	PIK3C2A PIK3C2G PIK3CB	9.97e-05	20	104	3	CID009849735
Disease	synucleinopathy (biomarker_via_orthology)	KIF1A KIF1B	6.93e-05	4	101	2	DOID:0050890 (biomarker_via_orthology)
Disease	Malignant tumor of breast	RAD51D CASP8 RB1CC1	1.07e-04	27	101	3	cv:C0006142
Disease	Breast neoplasm	RAD51D CASP8 RB1CC1	1.07e-04	27	101	3	cv:C1458155
Disease	Familial cancer of breast	RAD51D CASP8 RB1CC1	1.07e-04	27	101	3	cv:C0346153
Disease	relapsing-remitting multiple sclerosis (is_implicated_in)	NOD2 KLC1	1.15e-04	5	101	2	DOID:2378 (is_implicated_in)
Disease	Woolly hair, congenital	KRT74 KRT71	1.15e-04	5	101	2	C0345427
Disease	Hypotrichosis	KRT74 KRT71	1.72e-04	6	101	2	C0020678
Disease	Diabetes Mellitus	KIF1A NR1I2 NR1I3	1.80e-04	32	101	3	C0011849
Disease	Wooly hair	KRT74 KRT71	2.41e-04	7	101	2	C0343073
Disease	Hereditary spherocytosis	CAD SPTB	3.20e-04	8	101	2	C0037889
Disease	hepatocellular carcinoma	KIF1B MAU2 DLC1	3.78e-04	41	101	3	EFO_0000182
Disease	Neoplasm of uncertain or unknown behavior of breast	CASP8 PIK3CB MAP3K13	3.78e-04	41	101	3	C0496956
Disease	Breast adenocarcinoma	CASP8 PIK3CB MAP3K13	3.78e-04	41	101	3	C0858252
Disease	nervous system disease (implicated_via_orthology)	KIF1A KIF1B	7.49e-04	12	101	2	DOID:863 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	PDE2A STRBP UBR4 CASP8 RB1CC1 EPG5 NEDD4 PIK3CB RIC8A MAP3K13 LRBA	1.13e-03	1074	101	11	C0006142
Disease	HSV2 virologic severity measurement	KIF1B MGAT5B	1.18e-03	15	101	2	EFO_0009010
Disease	Situs ambiguus	PKD1L1 DNAH5	1.18e-03	15	101	2	C0266642
Disease	grip strength measurement	ARPP21 DNAH10 KIF1B GRM3 GRM7 R3HDM1	1.31e-03	350	101	6	EFO_0006941
Disease	melanoma	UBR4 CASP8 GRM3 TRRAP QPCT	1.66e-03	248	101	5	C0025202
Disease	cerebral microbleeds	CELA3B CTNNA2	1.91e-03	19	101	2	EFO_0010059
Disease	retinal vasculature measurement	STRBP WHAMMP3 RB1CC1 CELA3B THPO R3HDM1 DNAH5	2.03e-03	517	101	7	EFO_0010554
Disease	colorectal cancer (is_marker_for)	ERCC6L TGFB3 PIK3CB BAMBI	2.11e-03	157	101	4	DOID:9256 (is_marker_for)
Disease	haptoglobin measurement	DLC1 CHST4	2.33e-03	21	101	2	EFO_0004640
Disease	BREAST CANCER	CASP8 RB1CC1	2.33e-03	21	101	2	114480
Disease	Metabolic Syndrome X	NR1I2 NR1I3	2.33e-03	21	101	2	C0524620
Disease	progression free survival, ovarian serous carcinoma	VIT CTNNA2	2.56e-03	22	101	2	EFO_0004920, EFO_1001516
Disease	triacylglycerol 52:6 measurement	MAU2 GRM7	3.31e-03	25	101	2	EFO_0010418

Protein segments in the cluster

Peptide	Gene	Start	Entry
RVLILSQMILMLDIL	EP400	1916	Q96L91
LFMMILLAKEVQLVD	EPG5	2121	Q9HCE0
GEMTMDALLARLKLL	ANKLE2	61	Q86XL3
RALKSMTFLLMLLLI	CATSPER2	236	Q96P56
LQLMNLMLREKKISR	CTNNBL1	336	Q8WYA6
DIMEAMLKRLVSALI	AKAP4	421	Q5JQC9
MKMLTRLQVLTLALF	GRM3	1	Q14832
EIRTLLMEAENMALK	ALMS1	2261	Q8TCU4
MEMFQRLLLLLLLSM	CGB1	31	A6NKQ9
LKLMMNLLRDKSRNI	CAB39	256	Q9Y376
LIFRKLMLEKELASM	NPR2	476	P20594
SRDRMILLKMEQEII	ARPP21	161	Q9UBL0
KDMERLKEMLATLLI	ANO8	461	Q9HCE9
RDRMMLLKLEQEILD	R3HDM1	166	Q15032
LMMQLARELKTLARD	RAD51D	226	O75771
SQAIEMLLDLIMKRM	RAB27A	171	P51159
MKFQALRLTMLQRLE	RASSF4	301	Q9H2L5
MMLELARALDKKLLS	QPCT	166	Q16769
QLDKLRMIIESMLTS	QRICH2	1171	Q9H0J4
KLRQVMLNEMLLLDI	INTS8	606	Q75QN2
IRKHSQLLLNLLEMM	PIK3C2G	1106	O75747
MRKDMILSAEALALR	NR1I3	76	Q14994
MLSEEKQRIMLLERT	RB1CC1	1451	Q8TDY2
DRLLMILTKQRMIDN	DEPDC5	346	O75140
LQERMMSLLERIITK	MSANTD1	261	Q6ZTZ1
KVELMPRMRLLQSLL	FLII	756	Q13045
VLMMDSEKRIRLLQF	NEDD4	1231	P46934
SMMINKEDELRTVLL	NADK2	426	Q4G0N4
LRVILMEKSLIMEEN	MMRN2	446	Q9H8L6
SLEKLKQRLDLMREM	KIF1B	841	O60333
LLLNKEQLLAEMERM	PPFIA3	476	O75145
EMMLEQKLALLSRHL	KIAA2026	186	Q5HYC2
DLLELMVKRMDALAR	MGAT5B	76	Q3V5L5
LMLRRTETMVEKLLT	PLXNB3	1441	Q9ULL4
EDLRQDMLALQMIKI	PIK3C2A	1141	O00443
RMLDLMRDIILATDL	PDE2A	756	O00408
LLAFIMELLKNSIAM	LRBA	501	P50851
KLMLRTGLLMKLLSE	LRRC37B	841	Q96QE4
RLLKILDMASNIMIV	GBP4	606	Q96PP9
EMSALAKDLIQRLLM	RPS6KA5	281	O75582
MDRMTEDALRLNLLK	GATAD2B	1	Q8WXI9
AQLLRKIQLLCLMEM	PSMD13	266	Q9UNM6
LKIMAMLTELRSINA	NR1I2	391	O75469
MLKSRLRMFLNELKL	MARCHF9	1	Q86YJ5
LMELLEKMLALTLAK	MEI1	986	Q5TIA1
DIIELMMLLSAILTL	OR6C74	191	A6NCV1
LSAIMLQLEMREKEL	MAP3K13	486	O43283
RDMQLIALEQLCMLL	HECTD1	21	Q9ULT8
RLLILADMADVMRLL	CTNNA2	136	P26232
VLLIMLALRMLRSEN	BAMBI	166	Q13145
TLLSMEMKLRLLDLE	ELMO2	681	Q96JJ3
MMLRLLSSLLLVAVA	CELA3A	1	P09093
KFNLMLMDEDIISLL	C6orf50	26	Q9HD87
MMLRLLSSLLLVAVA	CELA3B	1	P08861
ALMLFQRLQEKRMLE	CASP8	41	Q14790
MELNALMLQLELKER	MAP3K12	441	Q12852
MVQLRKLLRVLTLMK	GRM7	1	Q14831
MSLLMISENVKLARE	KATNA1	1	O75449
LPDSILMKRLRNIMD	DNAH10	3691	Q8IVF4
EVLLLSMRDMNIAKL	DNAH2	2001	Q9P225
LKSMTILVLMLREFS	SLC22A14	476	Q9Y267
LFLLSKGMLLLMERK	MAU2	186	Q9Y6X3
LDLQKDMVVMLLSLL	RYR1	4016	P21817
RQLRIKLEMAMKELS	CCDC102B	121	Q68D86
RAALRDISMDILMLL	PKD1L1	2281	Q8TDX9
VMRVLRDMNLSKLID	DNAH5	2181	Q8TE73
KMIFLMDLLKRLRDE	ERCC6L	461	Q2NKX8
MIRKSLEMLELGLSE	KLC1	71	Q07866
TLEKLRQRLDLMREM	KIF1A	801	Q12756
VLQLLRMLAKDELMT	ORC3	456	Q9UBD5
IMKFIVSIDLMELSL	RPP40	141	O75818
EDLMQLLIRRTELLM	MIGA1	586	Q8NAN2
EVLKLMDAVMLQLTR	ROGDI	141	Q9GZN7
MRLLLLLLVAASAMV	SELENOT	1	P62341
ESRILDLRAMMEKLV	STAT2	146	P52630
LMESSRLKELLTMLQ	SYNE3	486	Q6ZMZ3
LMEVRRLFLSDMIKL	NBEA	861	Q8NFP9
MLRLSERNMKVLLAA	PPIB	1	P23284
LDSKAIDLMNALMRL	STRBP	381	Q96SI9
LMLARETLQLMRAKE	WHAMM	341	Q8TF30
ALVMLQEDELLSKMR	SYAP1	171	Q96A49
LQDLMEKVMVLNRSL	SEC31B	711	Q9NQW1
RQDMLTLQMLRLMDL	PIK3CB	811	P42338
EMLRNKLVRLMTHLD	RIC8A	371	Q9NPQ8
RLDSMVLLIMKLDQL	DLC1	351	Q96QB1
KMKLLLFLVSQMAIL	CHST4	6	Q8NCG5
KDQLLLMYLMDLTHL	NGDN	56	Q8NEJ9
ALALMLAKNVMLEEL	NOD2	946	Q9HC29
LVCMLLLLVLKLMRD	SLC26A11	206	Q86WA9
DARKILSNQEMLILM	SYCP2	186	Q9BX26
ILMINTLLALLLMII	MT-ND3	6	P03897
LTMKASVIEMFLVLL	VIT	6	Q6UXI7
RMLIKLLEVLSGEML	SPTB	86	P11277
ALAMLIIDLRMKSFL	TMEM168	186	Q9H0V1
TLRMMVQKERSLDIL	CAD	1946	P27708
NMLMLLIELVAERIK	USP24	206	Q9UPU5
VRKAAMTSLMDLTLL	TBCD	871	Q9BTW9
LMVIERGLLMLKTHL	USP34	1161	Q70CQ2
LKLMLAQETLQLMRA	WHAMMP3	66	Q1A5X7
MAILMLSLQLILLLI	UNQ5830/PRO19650/PRO19816	1	Q6UY13
HMVRLMLLERLLQTL	UBR4	2971	Q5T4S7
LSLELVKTRLAVMSM	TRRAP	2326	Q9Y4A5
MKMHLQRALVVLALL	TGFB3	1	P10600
MNLLLALLLDIMTVA	PLPP7	146	Q8NBV4
MELTELLLVVMLLLT	THPO	1	P40225
LQDLARKEMLELLDM	KIAA2013	311	Q8IYS2
MLREYQELMSLKLAL	KRT71	411	Q3SY84
MLREYQELMSLKLAL	KRT74	421	Q7RTS7