Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	endopeptidase activity	TPSAB1 PRSS12 BACE1 CFI PRSS36 ADAMTS10 CD5L ADAMTS7 ADAMTS6 ADAMTS20 PRSS42P TMPRSS2 PRSS45P BACE2 TPSB2	1.61e-08	430	111	15	GO:0004175
GeneOntologyMolecularFunction	peptidase activity	TPSAB1 PRSS12 BACE1 SCRN1 CFI PRSS36 ADAMTS10 CD5L ADAMTS7 ADAMTS6 ADAMTS20 PRSS42P TMPRSS2 PRSS45P BACE2 TPSB2	6.63e-07	654	111	16	GO:0008233
GeneOntologyMolecularFunction	serine-type endopeptidase activity	TPSAB1 PRSS12 CFI PRSS36 CD5L PRSS42P TMPRSS2 PRSS45P TPSB2	1.16e-06	190	111	9	GO:0004252
GeneOntologyMolecularFunction	serine-type peptidase activity	TPSAB1 PRSS12 CFI PRSS36 CD5L PRSS42P TMPRSS2 PRSS45P TPSB2	2.36e-06	207	111	9	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	TPSAB1 PRSS12 CFI PRSS36 CD5L PRSS42P TMPRSS2 PRSS45P TPSB2	2.87e-06	212	111	9	GO:0017171
GeneOntologyMolecularFunction	hepoxilin-epoxide hydrolase activity	ALOX12 ALOX15	3.06e-05	2	111	2	GO:0047977
GeneOntologyMolecularFunction	JUN kinase kinase kinase activity	MAP3K20 MAP3K9 MAP3K10	3.55e-05	12	111	3	GO:0004706
GeneOntologyMolecularFunction	linoleate 13S-lipoxygenase activity	ALOX12 ALOX15	9.15e-05	3	111	2	GO:0016165
GeneOntologyMolecularFunction	arachidonate 15-lipoxygenase activity	ALOX12 ALOX15	9.15e-05	3	111	2	GO:0050473
GeneOntologyMolecularFunction	arachidonate 12(S)-lipoxygenase activity	ALOX12 ALOX15	1.82e-04	4	111	2	GO:0004052
GeneOntologyMolecularFunction	peptide binding	LILRB3 FNTB BACE1 OXTR FCGRT SCTR MARCO SORL1	4.04e-04	318	111	8	GO:0042277
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	MAP3K20 MAP3K9 MAP3K10	4.44e-04	27	111	3	GO:0004709
GeneOntologyMolecularFunction	vasopressin receptor activity	NPSR1 OXTR	6.32e-04	7	111	2	GO:0005000
GeneOntologyMolecularFunction	amide binding	LILRB3 BACE1 RYR2 OXTR SCTR MARCO SORL1	1.42e-03	299	111	7	GO:0033218
GeneOntologyMolecularFunction	epoxide hydrolase activity	ALOX12 ALOX15	1.63e-03	11	111	2	GO:0004301
GeneOntologyMolecularFunction	inhibitory MHC class I receptor activity	LILRB3 LILRB4	1.95e-03	12	111	2	GO:0032396
GeneOntologyMolecularFunction	L-arginine transmembrane transporter activity	SLC66A1 SLC47A1	2.29e-03	13	111	2	GO:0061459
GeneOntologyMolecularFunction	hydrolase activity, acting on ether bonds	ALOX12 ALOX15	2.29e-03	13	111	2	GO:0016801
GeneOntologyMolecularFunction	ether hydrolase activity	ALOX12 ALOX15	2.29e-03	13	111	2	GO:0016803
GeneOntologyMolecularFunction	co-receptor binding	WNT9B WNT3A	2.29e-03	13	111	2	GO:0039706
GeneOntologyMolecularFunction	amyloid-beta binding	LILRB3 BACE1 MARCO SORL1	2.53e-03	102	111	4	GO:0001540
GeneOntologyMolecularFunction	azole transmembrane transporter activity	SLC66A1 SLC47A1	2.67e-03	14	111	2	GO:1901474
GeneOntologyBiologicalProcess	peptidyl-serine modification	GALNT1 GALNT2 MAP3K20 LATS1 WNT3A PKD1 MAP3K10 ATM PKN3	5.35e-05	319	110	9	GO:0018209
GeneOntologyBiologicalProcess	cellular response to interleukin-13	SHPK ALOX15	8.43e-05	3	110	2	GO:0035963
GeneOntologyBiologicalProcess	lipoxin A4 biosynthetic process	ALOX12 ALOX15	8.43e-05	3	110	2	GO:2001303
GeneOntologyBiologicalProcess	lipoxin A4 metabolic process	ALOX12 ALOX15	1.68e-04	4	110	2	GO:2001302
GeneOntologyBiologicalProcess	lipoxin biosynthetic process	ALOX12 ALOX15	1.68e-04	4	110	2	GO:2001301
GeneOntologyBiologicalProcess	morphogenesis of an endothelium	BSG CSNK2B ALOX12	1.83e-04	21	110	3	GO:0003159
GeneOntologyBiologicalProcess	endothelial tube morphogenesis	BSG CSNK2B ALOX12	1.83e-04	21	110	3	GO:0061154
GeneOntologyBiologicalProcess	regulation of adipose tissue development	SH3PXD2B LMNA SORL1	1.83e-04	21	110	3	GO:1904177
GeneOntologyBiologicalProcess	extracellular matrix organization	TPSAB1 ADAMTSL1 ADAMTS10 SH3PXD2B ADAMTS7 ADAMTS6 PTX3 WNT3A ADAMTS20	1.90e-04	377	110	9	GO:0030198
GeneOntologyBiologicalProcess	extracellular structure organization	TPSAB1 ADAMTSL1 ADAMTS10 SH3PXD2B ADAMTS7 ADAMTS6 PTX3 WNT3A ADAMTS20	1.93e-04	378	110	9	GO:0043062
GeneOntologyBiologicalProcess	external encapsulating structure organization	TPSAB1 ADAMTSL1 ADAMTS10 SH3PXD2B ADAMTS7 ADAMTS6 PTX3 WNT3A ADAMTS20	1.97e-04	379	110	9	GO:0045229
GeneOntologyCellularComponent	external encapsulating structure	TPSAB1 ADAMTSL1 PKHD1L1 ADAMTS10 ANGPTL6 ADAMTS7 ADAMTS6 PTX3 ANGPT4 ADAMTS20 HAPLN3 ANGPTL5 MARCO TPSB2	1.27e-05	658	113	14	GO:0030312
GeneOntologyCellularComponent	extracellular matrix	TPSAB1 ADAMTSL1 ADAMTS10 ANGPTL6 ADAMTS7 ADAMTS6 PTX3 ANGPT4 ADAMTS20 HAPLN3 ANGPTL5 MARCO TPSB2	5.49e-05	656	113	13	GO:0031012
GeneOntologyCellularComponent	Wnt-Frizzled-LRP5/6 complex	WNT9B WNT3A	2.87e-04	5	113	2	GO:1990851
GeneOntologyCellularComponent	collagen-containing extracellular matrix	TPSAB1 ADAMTSL1 ADAMTS10 ANGPTL6 ANGPT4 ADAMTS20 HAPLN3 ANGPTL5 MARCO TPSB2	6.06e-04	530	113	10	GO:0062023
Domain	SRCR	PRSS12 CFI CD163 CD5L CD163L1 TMPRSS2 HHIPL1 MARCO	2.66e-13	21	113	8	PF00530
Domain	SR	PRSS12 CFI CD163 CD5L CD163L1 TMPRSS2 HHIPL1 MARCO	1.39e-12	25	113	8	SM00202
Domain	-	PRSS12 CFI CD163 CD5L CD163L1 TMPRSS2 HHIPL1 MARCO	1.39e-12	25	113	8	3.10.250.10
Domain	SRCR_1	PRSS12 CFI CD163 CD5L CD163L1 TMPRSS2 HHIPL1 MARCO	1.99e-12	26	113	8	PS00420
Domain	SRCR_2	PRSS12 CFI CD163 CD5L CD163L1 TMPRSS2 HHIPL1 MARCO	1.99e-12	26	113	8	PS50287
Domain	SRCR-like_dom	PRSS12 CFI CD163 CD5L CD163L1 TMPRSS2 HHIPL1 MARCO	1.99e-12	26	113	8	IPR017448
Domain	SRCR	PRSS12 CFI CD163 CD5L CD163L1 TMPRSS2 HHIPL1 MARCO	2.82e-12	27	113	8	IPR001190
Domain	TRYPSIN_HIS	TPSAB1 PRSS12 CFI PRSS36 PRSS42P TMPRSS2 PRSS45P TPSB2	2.06e-07	103	113	8	IPR018114
Domain	TRYPSIN_SER	TPSAB1 PRSS12 CFI PRSS36 PRSS42P TMPRSS2 PRSS45P TPSB2	2.58e-07	106	113	8	PS00135
Domain	TRYPSIN_HIS	TPSAB1 PRSS12 CFI PRSS36 PRSS42P TMPRSS2 PRSS45P TPSB2	2.77e-07	107	113	8	PS00134
Domain	Peptidase_M12B_ADAM-TS	ADAMTSL1 ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	2.88e-07	24	113	5	IPR013273
Domain	Peptidase_S1A	TPSAB1 PRSS12 CFI PRSS36 PRSS42P TMPRSS2 PRSS45P TPSB2	4.22e-07	113	113	8	IPR001314
Domain	TRYPSIN_DOM	TPSAB1 PRSS12 CFI PRSS36 PRSS42P TMPRSS2 PRSS45P TPSB2	4.83e-07	115	113	8	PS50240
Domain	Tryp_SPc	TPSAB1 PRSS12 CFI PRSS36 PRSS42P TMPRSS2 PRSS45P TPSB2	5.51e-07	117	113	8	SM00020
Domain	Trypsin	TPSAB1 PRSS12 CFI PRSS36 PRSS42P TMPRSS2 PRSS45P TPSB2	7.13e-07	121	113	8	PF00089
Domain	Trypsin_dom	TPSAB1 PRSS12 CFI PRSS36 PRSS42P TMPRSS2 PRSS45P TPSB2	7.13e-07	121	113	8	IPR001254
Domain	Peptidase_S1_PA	TPSAB1 PRSS12 CFI PRSS36 PRSS42P TMPRSS2 PRSS45P TPSB2	8.08e-07	123	113	8	IPR009003
Domain	TSP_1	ADAMTSL1 ADAMTS10 UNC5A ADAMTS7 ADAMTS6 ADAMTS20	2.20e-06	63	113	6	PF00090
Domain	TSP1	ADAMTSL1 ADAMTS10 UNC5A ADAMTS7 ADAMTS6 ADAMTS20	2.65e-06	65	113	6	SM00209
Domain	TSP1_rpt	ADAMTSL1 ADAMTS10 UNC5A ADAMTS7 ADAMTS6 ADAMTS20	2.65e-06	65	113	6	IPR000884
Domain	TSP1	ADAMTSL1 ADAMTS10 UNC5A ADAMTS7 ADAMTS6 ADAMTS20	2.65e-06	65	113	6	PS50092
Domain	PLAC	ADAMTSL1 ADAMTS10 ADAMTS7 ADAMTS6	4.59e-06	19	113	4	PS50900
Domain	PLAC	ADAMTSL1 ADAMTS10 ADAMTS7 ADAMTS6	4.59e-06	19	113	4	IPR010909
Domain	6-blade_b-propeller_TolB-like	NHLRC3 NHLRC2 TECPR2 HHIPL1 SORL1	8.34e-06	46	113	5	IPR011042
Domain	ADAM_spacer1	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	1.03e-05	23	113	4	IPR010294
Domain	ADAM_spacer1	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	1.03e-05	23	113	4	PF05986
Domain	TRYPSIN_SER	TPSAB1 PRSS12 CFI PRSS36 TMPRSS2 TPSB2	1.77e-05	90	113	6	IPR033116
Domain	BACE	BACE1 BACE2	3.63e-05	2	113	2	IPR009119
Domain	Memapsin-like	BACE1 BACE2	3.63e-05	2	113	2	IPR033874
Domain	-	SAMD4B SAMD4A	3.63e-05	2	113	2	1.25.40.170
Domain	PHAT_dom	SAMD4B SAMD4A	3.63e-05	2	113	2	IPR015327
Domain	PLAC	ADAMTSL1 ADAMTS10 ADAMTS6	7.48e-05	14	113	3	PF08686
Domain	Peptidase_M12B_N	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	8.87e-05	39	113	4	IPR002870
Domain	Pep_M12B_propep	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	8.87e-05	39	113	4	PF01562
Domain	-	NHLRC3 NHLRC2 HHIPL1 SORL1	8.87e-05	39	113	4	2.120.10.30
Domain	DISINTEGRIN_1	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	9.81e-05	40	113	4	PS00427
Domain	Reprolysin	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	9.81e-05	40	113	4	PF01421
Domain	ADAM_MEPRO	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	9.81e-05	40	113	4	PS50215
Domain	DISINTEGRIN_2	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	9.81e-05	40	113	4	PS50214
Domain	Peptidase_M12B	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	9.81e-05	40	113	4	IPR001590
Domain	Disintegrin_dom	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	1.08e-04	41	113	4	IPR001762
Domain	LH2	PKD1 ALOX12 ALOX15	1.65e-04	18	113	3	SM00308
Domain	Fibrinogen_CS	ANGPTL6 ANGPT4 ANGPTL5	1.95e-04	19	113	3	IPR020837
Domain	LDLRA_1	CFI PKD1 TMPRSS2 SORL1	2.01e-04	48	113	4	PS01209
Domain	MLK1/MLK2/MLK4	MAP3K9 MAP3K10	2.16e-04	4	113	2	IPR016231
Domain	MAP3K10	MAP3K9 MAP3K10	2.16e-04	4	113	2	IPR015785
Domain	LDLRA_2	CFI PKD1 TMPRSS2 SORL1	2.18e-04	49	113	4	PS50068
Domain	PLAT	PKD1 ALOX12 ALOX15	2.65e-04	21	113	3	PS50095
Domain	-	PKD1 ALOX12 ALOX15	2.65e-04	21	113	3	2.60.60.20
Domain	PLAT	PKD1 ALOX12 ALOX15	2.65e-04	21	113	3	PF01477
Domain	PLAT/LH2_dom	PKD1 ALOX12 ALOX15	2.65e-04	21	113	3	IPR001024
Domain	RCC1/BLIP-II	TECPR2 SERGEF HERC1	3.50e-04	23	113	3	IPR009091
Domain	PFTB_repeat	FNTB LSS	3.59e-04	5	113	2	IPR001330
Domain	Vasoprsn_rcpt	NPSR1 OXTR	3.59e-04	5	113	2	IPR001817
Domain	Prenyltrans	FNTB LSS	3.59e-04	5	113	2	PF00432
Domain	Fibrinogen_a/b/g_C_2	ANGPTL6 ANGPT4 ANGPTL5	3.98e-04	24	113	3	IPR014715
Domain	-	ANGPTL6 ANGPT4 ANGPTL5	3.98e-04	24	113	3	4.10.530.10
Domain	LipOase_mml	ALOX12 ALOX15	5.36e-04	6	113	2	IPR001885
Domain	LIPOXYGENASE_1	ALOX12 ALOX15	5.36e-04	6	113	2	PS00711
Domain	LipOase_C	ALOX12 ALOX15	5.36e-04	6	113	2	IPR013819
Domain	Lipoxygenase	ALOX12 ALOX15	5.36e-04	6	113	2	PF00305
Domain	LIPOXYGENASE_3	ALOX12 ALOX15	5.36e-04	6	113	2	PS51393
Domain	LIPOXYGENASE_2	ALOX12 ALOX15	5.36e-04	6	113	2	PS00081
Domain	LipOase	ALOX12 ALOX15	5.36e-04	6	113	2	IPR000907
Domain	LipOase_Fe_BS	ALOX12 ALOX15	5.36e-04	6	113	2	IPR020833
Domain	LipOase_CS	ALOX12 ALOX15	5.36e-04	6	113	2	IPR020834
Domain	Fibrinogen_C	ANGPTL6 ANGPT4 ANGPTL5	5.67e-04	27	113	3	PF00147
Domain	FBG	ANGPTL6 ANGPT4 ANGPTL5	7.03e-04	29	113	3	SM00186
Domain	-	ANGPTL6 ANGPT4 ANGPTL5	7.77e-04	30	113	3	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	ANGPTL6 ANGPT4 ANGPTL5	7.77e-04	30	113	3	IPR014716
Domain	FIBRINOGEN_C_1	ANGPTL6 ANGPT4 ANGPTL5	9.41e-04	32	113	3	PS00514
Domain	Fibrinogen_a/b/g_C_dom	ANGPTL6 ANGPT4 ANGPTL5	9.41e-04	32	113	3	IPR002181
Domain	FIBRINOGEN_C_2	ANGPTL6 ANGPT4 ANGPTL5	9.41e-04	32	113	3	PS51406
Domain	WD40	STRN3 RAE1 WDR26 TECPR2 WDR41 HERC1 BRWD1	1.23e-03	268	113	7	SM00320
Domain	NHL_repeat_subgr	NHLRC3 NHLRC2	1.27e-03	9	113	2	IPR013017
Domain	WD40_repeat	STRN3 RAE1 WDR26 TECPR2 WDR41 HERC1 BRWD1	1.34e-03	272	113	7	IPR001680
Domain	MetalloPept_cat_dom	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	1.48e-03	81	113	4	IPR024079
Domain	-	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	1.48e-03	81	113	4	3.40.390.10
Domain	WD_REPEATS_1	STRN3 RAE1 WDR26 TECPR2 WDR41 HERC1 BRWD1	1.52e-03	278	113	7	PS00678
Domain	WD_REPEATS_2	STRN3 RAE1 WDR26 TECPR2 WDR41 HERC1 BRWD1	1.55e-03	279	113	7	PS50082
Domain	WD_REPEATS_REGION	STRN3 RAE1 WDR26 TECPR2 WDR41 HERC1 BRWD1	1.55e-03	279	113	7	PS50294
Domain	Aspartic_peptidase_A1	BACE1 BACE2	1.58e-03	10	113	2	IPR001461
Domain	PEPTIDASE_A1	BACE1 BACE2	1.58e-03	10	113	2	IPR033121
Domain	NHL	NHLRC3 NHLRC2	1.58e-03	10	113	2	PF01436
Domain	Asp	BACE1 BACE2	1.58e-03	10	113	2	PF00026
Domain	PEPTIDASE_A1	BACE1 BACE2	1.58e-03	10	113	2	PS51767
Domain	NHL_repeat	NHLRC3 NHLRC2	1.58e-03	10	113	2	IPR001258
Domain	LDLR_class-A_CS	CFI TMPRSS2 SORL1	1.81e-03	40	113	3	IPR023415
Domain	PKD	TMEM130 PKD1	1.93e-03	11	113	2	PS50093
Domain	PKD_dom	TMEM130 PKD1	1.93e-03	11	113	2	IPR000601
Domain	-	TMEM130 PKD1	1.93e-03	11	113	2	2.60.40.670
Domain	WD40_repeat_dom	STRN3 RAE1 WDR26 TECPR2 WDR41 HERC1 BRWD1	2.20e-03	297	113	7	IPR017986
Domain	-	BACE1 BACE2	2.30e-03	12	113	2	2.40.70.10
Domain	ASP_PROTEASE	BACE1 BACE2	2.30e-03	12	113	2	PS00141
Domain	PMP22/EMP/MP20/Claudin	TMEM182 CLDN16 EMP3	2.54e-03	45	113	3	IPR004031
Domain	-	CFI TMPRSS2 SORL1	2.71e-03	46	113	3	4.10.400.10
Domain	Aspartic_peptidase_AS	BACE1 BACE2	2.71e-03	13	113	2	IPR001969
Domain	NHL	NHLRC3 NHLRC2	2.71e-03	13	113	2	PS51125
Domain	ZINC_PROTEASE	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	2.97e-03	98	113	4	PS00142
Domain	Dynein_HC_stalk	DNHD1 DYNC1H1	3.15e-03	14	113	2	IPR024743
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTSL1 ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	3.67e-06	39	86	5	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTSL1 ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	3.67e-06	39	86	5	MM15165
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTSL1 GALNT1 GALNT2 ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	4.43e-06	109	86	7	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTSL1 GALNT1 GALNT2 ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	4.99e-06	111	86	7	M27416
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	PRSS12 CFI CD163 CD5L CLCN5 CD163L1 TMPRSS2 LSS HHIPL1 MARCO SORL1	1.93e-05	381	86	11	M48063
Pathway	KEGG_MEDICUS_REFERENCE_MLK_JNK_SIGNALING_PATHWAY	MAP3K20 MAP3K9 MAP3K10	4.63e-05	12	86	3	M47929
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTSL1 ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	5.79e-05	68	86	5	M27303
Pubmed	Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments.	BACE1 ALOX12 ALOX15	3.43e-08	3	114	3	22275252
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	CA11 DNHD1 TMEM182 ADAMTSL1 WNT9B ANGPTL6 TMEM130 CD5L BSG CD163L1 HAPLN3 HHIPL1 SPACA5 BACE2 SMOX ANGPTL5	1.46e-07	985	114	16	12975309
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTSL1 ADAMTS10 UNC5A ADAMTS7 ADAMTS6 ADAMTS20	1.82e-07	75	114	6	20637190
Pubmed	A gene(s) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11.	WNT9B ALOX12 ALOX15	1.90e-06	8	114	3	15781699
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	RAE1 NPSR1 BACE1 PGM2L1 SLC22A17 OXTR DNAJC14 TECPR2 BSG CSNK2B PKD1 LSS	3.28e-06	697	114	12	28298427
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS10 ADAMTS7 ADAMTS6	4.05e-06	10	114	3	11167130
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CA11 GPRASP1 GALNT2 SHROOM2 WDR26 DNAJC14 CSNK2B ZNF197 SERGEF PKD1 MAP3K10 ATM BACE2 DYNC1H1 BRWD1 ZNF662	4.71e-06	1285	114	16	35914814
Pubmed	Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.	ADAMTS10 ADAMTS7 ADAMTS20	7.38e-06	12	114	3	25770910
Pubmed	Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells.	ALOX12 ALOX15	1.07e-05	2	114	2	30792307
Pubmed	Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.	ALOX12 ALOX15	1.07e-05	2	114	2	25251155
Pubmed	A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense.	ALOX12 ALOX15	1.07e-05	2	114	2	15708862
Pubmed	The structure of the human betaII-tryptase tetramer: fo(u)r better or worse.	TPSAB1 TPSB2	1.07e-05	2	114	2	10500112
Pubmed	Altered beta-secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain.	BACE1 BACE2	1.07e-05	2	114	2	17113083
Pubmed	Enhancement role of host 12/15-lipoxygenase in melanoma progression.	ALOX12 ALOX15	1.07e-05	2	114	2	23664097
Pubmed	Lipoxygenase metabolites are mediators of PTH-dependent human osteoblast growth.	ALOX12 ALOX15	1.07e-05	2	114	2	18187376
Pubmed	Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress.	NLRP3 ATM	1.07e-05	2	114	2	36746533
Pubmed	A comparative molecular dynamics study on BACE1 and BACE2 flap flexibility.	BACE1 BACE2	1.07e-05	2	114	2	26804314
Pubmed	Umbilical cord blood concentration of soluble scavenger receptor for hemoglobin, but not pentraxin 3, is of value for the early postpartum identification of the presence of histological chorioamnionitis.	CD163 PTX3	1.07e-05	2	114	2	21933102
Pubmed	Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families.	ALOX12 ALOX15	1.07e-05	2	114	2	22089472
Pubmed	Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells.	BACE1 BACE2	1.07e-05	2	114	2	16757811
Pubmed	12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice.	ALOX12 ALOX15	1.07e-05	2	114	2	19787041
Pubmed	Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.	BACE1 BACE2	1.07e-05	2	114	2	15987683
Pubmed	Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains.	MAP3K9 MAP3K10	1.07e-05	2	114	2	8477742
Pubmed	Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases.	ALOX12 ALOX15	1.07e-05	2	114	2	18547056
Pubmed	12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet.	ALOX12 ALOX15	1.07e-05	2	114	2	18780776
Pubmed	Assignment of CD163B, the gene encoding M160, a novel scavenger receptor, to human chromosome 12p13.3 by in situ hybridization and somatic cell hybrid analysis.	CD163 CD163L1	1.07e-05	2	114	2	11124526
Pubmed	Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.	TPSAB1 TPSB2	1.07e-05	2	114	2	10898108
Pubmed	Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2.	MAP3K9 MAP3K10	1.07e-05	2	114	2	8536694
Pubmed	The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs.	ALOX12 ALOX15	1.07e-05	2	114	2	30237084
Pubmed	Human ALOX12, but not ALOX15, is associated with BMD in white men and women.	ALOX12 ALOX15	1.07e-05	2	114	2	16598376
Pubmed	Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells.	BACE1 BACE2	1.07e-05	2	114	2	12801932
Pubmed	Amino acid sequence and structural comparison of BACE1 and BACE2 using evolutionary trace method.	BACE1 BACE2	1.07e-05	2	114	2	25254246
Pubmed	Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids.	SLC66A1 WDR41	1.07e-05	2	114	2	33597295
Pubmed	Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation.	ALOX12 ALOX15	1.07e-05	2	114	2	15681297
Pubmed	Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.	TPSAB1 TPSB2	1.07e-05	2	114	2	9521329
Pubmed	Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.	ALOX12 ALOX15	1.07e-05	2	114	2	29184033
Pubmed	Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases.	BACE1 BACE2	1.07e-05	2	114	2	11741910
Pubmed	Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice.	ALOX12 ALOX15	1.07e-05	2	114	2	10330425
Pubmed	β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.	BACE1 BACE2	1.07e-05	2	114	2	22903875
Pubmed	Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.	ALOX12 ALOX15	1.07e-05	2	114	2	18755188
Pubmed	Splice variants of the beta-site APP-cleaving enzyme BACE1 in human brain and pancreas.	BACE1 BACE2	1.07e-05	2	114	2	12054559
Pubmed	Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft.	TPSAB1 TPSB2	1.07e-05	2	114	2	10391906
Pubmed	BACE1 and BACE2 in pathologic and normal human muscle.	BACE1 BACE2	1.07e-05	2	114	2	12618121
Pubmed	Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.	ALOX12 ALOX15	1.07e-05	2	114	2	25293588
Pubmed	Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase.	ALOX12 ALOX15	1.07e-05	2	114	2	12731864
Pubmed	Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease.	PKD1 ATM	1.07e-05	2	114	2	33802342
Pubmed	The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.	ALOX12 ALOX15	1.07e-05	2	114	2	22267335
Pubmed	Picrorhiza kurroa Prevents Memory Deficits by Inhibiting NLRP3 Inflammasome Activation and BACE1 Expression in 5xFAD Mice.	BACE1 NLRP3	1.07e-05	2	114	2	31741224
Pubmed	Significant elevation of CLDN16 and HAPLN3 gene expression in human breast cancer.	CLDN16 HAPLN3	1.07e-05	2	114	2	20664984
Pubmed	Overexpression of 12/15-lipoxygenase increases anxiety behavior in female mice.	ALOX12 ALOX15	1.07e-05	2	114	2	24300237
Pubmed	Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies.	ALOX12 ALOX15	1.07e-05	2	114	2	30472260
Pubmed	Glutathione disulfide induces neural cell death via a 12-lipoxygenase pathway.	ALOX12 ALOX15	1.07e-05	2	114	2	19373248
Pubmed	A Non-Canonical Role for β-Secretase in the Retina.	BACE1 BACE2	1.07e-05	2	114	2	26427429
Pubmed	Expression analysis of BACE2 in brain and peripheral tissues.	BACE1 BACE2	1.07e-05	2	114	2	10749877
Pubmed	Role of Src tyrosine kinase in the atherogenic effects of the 12/15-lipoxygenase pathway in vascular smooth muscle cells.	ALOX12 ALOX15	1.07e-05	2	114	2	19095999
Pubmed	Differential expression and localization of 12/15 lipoxygenases in adipose tissue in human obese subjects.	ALOX12 ALOX15	1.07e-05	2	114	2	21094135
Pubmed	Characterization of a tryptase mRNA expressed in the human basophil cell line KU812.	TPSAB1 TPSB2	1.07e-05	2	114	2	8434231
Pubmed	The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis.	MAP3K9 MAP3K10	1.07e-05	2	114	2	11416147
Pubmed	EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation.	ALOX12 ALOX15	1.07e-05	2	114	2	21220563
Pubmed	12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.	ALOX12 ALOX15	1.07e-05	2	114	2	23528921
Pubmed	Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase.	GALNT1 GALNT2	1.07e-05	2	114	2	7592619
Pubmed	Cloning and characterization of a second complementary DNA for human tryptase.	TPSAB1 TPSB2	1.07e-05	2	114	2	2203827
Pubmed	Alox12/15 Deficiency Exacerbates, While Lipoxin A4 Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis.	ALOX12 ALOX15	1.07e-05	2	114	2	32760397
Pubmed	Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy.	ALOX12 ALOX15	1.07e-05	2	114	2	25187369
Pubmed	12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response.	ALOX12 ALOX15	1.07e-05	2	114	2	22215650
Pubmed	Systematic proteomic analysis identifies β-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic β-cells.	BACE1 BACE2	1.07e-05	2	114	2	23430253
Pubmed	Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.	BACE1 BACE2	1.07e-05	2	114	2	12093293
Pubmed	Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules.	SAMD4B SAMD4A	1.07e-05	2	114	2	16221671
Pubmed	Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.	ALOX12 ALOX15	1.07e-05	2	114	2	19469483
Pubmed	12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.	ALOX12 ALOX15	1.07e-05	2	114	2	15111312
Pubmed	Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women.	ALOX12 ALOX15	1.07e-05	2	114	2	17520163
Pubmed	beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.	BACE1 BACE2	1.07e-05	2	114	2	20163459
Pubmed	BACE1 and BACE2 enzymatic activities in Alzheimer's disease.	BACE1 BACE2	1.07e-05	2	114	2	19968762
Pubmed	Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.	BACE1 BACE2	1.07e-05	2	114	2	15857888
Pubmed	Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase.	ALOX12 ALOX15	1.07e-05	2	114	2	20570249
Pubmed	Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.	ALOX12 ALOX15	1.07e-05	2	114	2	32324389
Pubmed	ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-κB pathway.	CD163 ANGPT4	1.07e-05	2	114	2	34146541
Pubmed	ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions.	ADAMTS10 ADAMTS6	1.07e-05	2	114	2	27779234
Pubmed	Reactive oxygen species and 12/15-lipoxygenase contribute to the antiproliferative capacity of alternatively activated myeloid cells elicited during helminth infection.	ALOX12 ALOX15	1.07e-05	2	114	2	15879104
Pubmed	Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.	TPSAB1 TPSB2	1.07e-05	2	114	2	2187193
Pubmed	BACE2 distribution in major brain cell types and identification of novel substrates.	BACE1 BACE2	1.07e-05	2	114	2	30456346
Pubmed	Kidney Cyst Lining Epithelial Cells Are Resistant to Low-Dose Cisplatin-Induced DNA Damage in a Preclinical Model of Autosomal Dominant Polycystic Kidney Disease.	PKD1 ATM	1.07e-05	2	114	2	36293397
Pubmed	Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase.	TPSAB1 TPSB2	1.07e-05	2	114	2	15567416
Pubmed	The human mast cell tryptase tetramer: a fascinating riddle solved by structure.	TPSAB1 TPSB2	1.07e-05	2	114	2	10708850
Pubmed	12-Lipoxygenase isoenzymes in mouse skin tumor development.	ALOX12 ALOX15	1.07e-05	2	114	2	7576099
Pubmed	Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels.	TPSAB1 TPSB2	1.07e-05	2	114	2	17449330
Pubmed	Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia.	TPSAB1 TPSB2	1.07e-05	2	114	2	31337736
Pubmed	The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease.	ALOX12 ALOX15	1.07e-05	2	114	2	25708815
Pubmed	Lack of association of ALOX12 and ALOX15 polymorphisms with aspirin-exacerbated respiratory disease in Korean patients.	ALOX12 ALOX15	1.07e-05	2	114	2	19663136
Pubmed	12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis.	ALOX12 ALOX15	1.07e-05	2	114	2	19675173
Pubmed	c-Met and NF-κB-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease.	WNT9B WNT3A PKD1	1.86e-05	16	114	3	22677559
Pubmed	Human 5-, 12- and 15-lipoxygenase-1 coexist in kidney but show opposite trends and their balance changes in cancer.	ALOX12 ALOX15	3.19e-05	3	114	2	22825379
Pubmed	5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.	ALOX12 ALOX15	3.19e-05	3	114	2	18346986
Pubmed	Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.	ALOX12 ALOX15	3.19e-05	3	114	2	22279185
Pubmed	Protein expression of BACE1, BACE2 and APP in Down syndrome brains.	BACE1 BACE2	3.19e-05	3	114	2	18163181
Pubmed	Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.	BACE1 SORL1	3.19e-05	3	114	2	16407538
Pubmed	Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).	ALOX12 ALOX15	3.19e-05	3	114	2	19752233
Pubmed	Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype.	MAP3K9 MAP3K10	3.19e-05	3	114	2	18414056
Pubmed	Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.	BACE1 BACE2	3.19e-05	3	114	2	12665519
Pubmed	Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.	ALOX12 ALOX15	3.19e-05	3	114	2	18296557
Interaction	TPSAB1 interactions	TPSAB1 MAP3K10 ATM TPSB2	7.49e-07	14	108	4	int:TPSAB1
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS10 ADAMTS7 ADAMTS6 ADAMTS20	1.38e-06	19	81	4	50
GeneFamily	Proteases, serine	PRSS12 PRSS36 PRSS42P TMPRSS2 PRSS45P	9.13e-06	63	81	5	738
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K20 MAP3K9 MAP3K10	1.64e-04	24	81	3	654
GeneFamily	Fibrinogen C domain containing	ANGPTL6 ANGPT4 ANGPTL5	1.86e-04	25	81	3	554
GeneFamily	CD molecules\|Inhibitory leukocyte immunoglobulin like receptors	LILRB3 LILRB4	1.97e-04	5	81	2	1182
GeneFamily	C2-set domain containing\|Immunoglobulin like domain containing\|Scavenger receptors	CD163 CD163L1 MARCO	2.34e-04	27	81	3	1253
GeneFamily	Arachidonate lipoxygenases	ALOX12 ALOX15	2.94e-04	6	81	2	407
GeneFamily	Fibrinogen C domain containing\|Angiopoietin like	ANGPTL6 ANGPTL5	5.45e-04	8	81	2	905
GeneFamily	WD repeat domain containing	STRN3 RAE1 WDR26 WDR41 HERC1 BRWD1	1.14e-03	262	81	6	362
GeneFamily	Wnt family\|Endogenous ligands	WNT9B WNT3A	3.23e-03	19	81	2	360
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT1 GALNT2	3.57e-03	20	81	2	433
Coexpression	DESCARTES_FETAL_ADRENAL_MYELOID_CELLS	LILRB3 CD163 NLRP3 CD5L CD163L1 MARCO LILRB4	1.70e-05	185	114	7	M40148
Coexpression	GSE24634_TREG_VS_TCONV_POST_DAY7_IL4_CONVERSION_DN	GPRASP1 CD163 NLRP3 FCGRT SLC47A1 MARCO LILRB4	2.63e-05	198	114	7	M4606
Coexpression	GSE19888_CTRL_VS_A3R_ACT_TREATED_MAST_CELL_PRETREATED_WITH_A3R_INH_DN	LXN SLC22A17 CD163 ADAMTS10 SHPK TUBE1 MARCO	2.71e-05	199	114	7	M7351
Coexpression	GSE20366_EX_VIVO_VS_HOMEOSTATIC_CONVERSION_NAIVE_CD4_TCELL_DN	CFI CD5L CLCN5 SLC16A2 FCGRT CLDN16 MAP3K9	2.80e-05	200	114	7	M4326
Coexpression	DESCARTES_FETAL_PLACENTA_MYELOID_CELLS	CD163 NLRP3 CD5L CD163L1 MARCO LILRB4	4.38e-05	146	114	6	M40285
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3K27ME3	WNT9B RYR2 UNC5A TMEM130 OXTR WNT3A SCTR TMPRSS2 SLC47A1 ALOX12 ALOX15	5.52e-05	591	114	11	M2019
Coexpression	MIKKELSEN_MEF_HCP_WITH_H3K27ME3	WNT9B RYR2 UNC5A TMEM130 OXTR WNT3A SCTR TMPRSS2 SLC47A1 ALOX12 ALOX15	6.41e-05	601	114	11	MM866
Coexpression	DESCARTES_MAIN_FETAL_MYELOID_CELLS	LILRB3 CD163 NLRP3 CD163L1 MARCO	7.01e-05	98	114	5	M40071
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	TPSAB1 HTR1B PRSS12 NPSR1 PKHD1L1 TPSB2 SORL1	1.52e-08	111	114	7	1847dde68d349114286bc3317be6339666df4aa2
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_granulocytic-mast_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TPSAB1 PRSS12 LXN LMNA ADAMTS7 EMP3 BACE2 TPSB2	3.28e-08	190	114	8	7774dc0b4ae7d5920b516800f3b90cbf831f8d3d
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 LILRB3 CD163 NLRP3 CD163L1 MARCO TPSB2 LILRB4	4.69e-08	199	114	8	a4785c1921a3de18a9190e4d674ede6a90f80004
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	GPRASP1 TPSAB1 SHROOM2 SLC22A17 ADAMTS6 DSEL TPSB2	2.63e-07	168	114	7	45ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LILRB3 SCRN1 CD163 NLRP3 CD5L MARCO LILRB4	2.73e-07	169	114	7	0f5e737b265ba333275a0cd289dab029a1542075
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LILRB3 SCRN1 CD163 NLRP3 CD5L MARCO LILRB4	2.73e-07	169	114	7	aec1b4c7e973a31c53aaea47c2c05d24ce16aa4f
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage1_(2)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	LILRB3 CD163 NLRP3 CD5L CD163L1 MARCO LILRB4	6.46e-07	192	114	7	4e3deefd30adb7bf1eba294610eed3d077aa9418
ToppCell	3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TPSAB1 MAS1L LMNA ADAMTS7 EMP3 BACE2 TPSB2	6.93e-07	194	114	7	a85e98af9dc9a4f0437be3700d63a6d21415199b
ToppCell	IPF-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	CD163 NLRP3 SH3PXD2B CD163L1 EMP3 MARCO LILRB4	7.17e-07	195	114	7	50edda117b438b9c3616191884007466f6d974f0
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 CD163 NLRP3 EMP3 MARCO TPSB2 LILRB4	7.42e-07	196	114	7	23e22dfb9f9aec17b83574295f889e75f46ded50
ToppCell	IPF-Myeloid-Macrophage\|IPF / Disease state, Lineage and Cell class	CD163 NLRP3 SH3PXD2B CD163L1 EMP3 MARCO LILRB4	7.68e-07	197	114	7	a2ffb33c7cad6be43cbb8ed9a91338923cc07db4
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LILRB3 HTR1B CD163 NLRP3 SH3PXD2B FCGRT CD163L1	7.95e-07	198	114	7	c7dbf24caae5c4ef285845d13055de9e07281bb3
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPIB CDHR2 LXN BSG CD163L1 CNTFR SORL1	8.22e-07	199	114	7	01d101b0fd5326947a9e5dddae6c2f93ab6e0a4d
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 LILRB3 CD163 NLRP3 CD163L1 TPSB2 LILRB4	8.22e-07	199	114	7	c684530d4d8073337379c2a24e5e54297fb13691
ToppCell	Tracheal-NucSeq-Immune_Myeloid\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TPSAB1 LILRB3 CD163 NLRP3 MARCO TPSB2 LILRB4	8.50e-07	200	114	7	ad7ae5106141669b353800fece833b3cd5bdccee
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TPSAB1 LILRB3 CD163 NLRP3 MARCO TPSB2 LILRB4	8.50e-07	200	114	7	c325dc52e4bf3829a35905b956784ca3e9191926
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LILRB3 CD163 NLRP3 SH3PXD2B CD163L1 MARCO LILRB4	8.50e-07	200	114	7	78d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCell	Bronchus_Control_(B.)-Immune-TX-MoAM-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	LILRB3 CD163 NLRP3 PTX3 EMP3 MARCO LILRB4	8.50e-07	200	114	7	fe7f8b04067b6680b69c8523f0fa514ef97207e2
ToppCell	356C-Myeloid-Mast_cell\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	GPRASP1 TPSAB1 PRSS12 SLC22A17 BACE2 TPSB2	4.12e-06	164	114	6	b3192c443f4848e6a8afdb89c155f9ec42a154b0
ToppCell	356C-Myeloid-Mast_cell-\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	GPRASP1 TPSAB1 PRSS12 SLC22A17 BACE2 TPSB2	4.12e-06	164	114	6	f7288ec4daf494dae770ea6c58bead27660ccae1
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Macrophage-macrophage,_alveolar\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LILRB3 CD163 NLRP3 PTX3 CD163L1 MARCO	4.42e-06	166	114	6	28a44448a0b0d72459e8fe84ce5d666f16f514b3
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Macrophage\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LILRB3 CD163 NLRP3 PTX3 CD163L1 MARCO	4.42e-06	166	114	6	2a04915d534a83e65aa168435d6856125b5bdd78
ToppCell	mild-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	TPSAB1 ABCC1 TMEM130 BACE2 TPSB2 ALOX15	5.24e-06	171	114	6	5c8198182495bda7a826e9d80aa467f4eb1094ec
ToppCell	368C-Myeloid-Mast_cell\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TPSAB1 PRSS12 LMNA ADAMTS7 BACE2 TPSB2	5.60e-06	173	114	6	8cffb4a37d30b6626188309b868ac4a62e91262f
ToppCell	368C-Myeloid-Mast_cell-\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TPSAB1 PRSS12 LMNA ADAMTS7 BACE2 TPSB2	5.60e-06	173	114	6	fb87ea74bf70aa83b458edf728c81857c8b8eb96
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Intermediate_macrophages\|bone_marrow / Manually curated celltypes from each tissue	CD163 NLRP3 SH3PXD2B FCGRT PTX3 MARCO	5.79e-06	174	114	6	268abfc4d53a3ba3931dbcafffef09a72ea0edfa
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_MT-positive-Alveolar_macrophage_MT-positive_L.1.0.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD163 LMNA CD163L1 EMP3 MARCO LILRB4	5.99e-06	175	114	6	b227d4499274fb63b193d34de7f2d812e283e79d
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_MT-positive\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD163 LMNA CD163L1 EMP3 MARCO LILRB4	5.99e-06	175	114	6	308ee4ef7b9ecea68efca011ef91aed0f1be0eca
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 CENPL SHROOM2 PKHD1L1 ANGPTL6 SMOX	5.99e-06	175	114	6	0801cccec6915aefc135262fc74580280fd51aa5
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTSL1 CENPL SHROOM2 PKHD1L1 ANGPTL6 SMOX	5.99e-06	175	114	6	09163e7030f76d706eccabdb1d5ec45f8412aa75
ToppCell	facs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PRSS12 SHROOM2 SLC22A17 OXTR SHPK ADAMTS20	6.39e-06	177	114	6	59cf56c385c324f0844f20003d2b5049a2791e45
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SPIB MAP3K20 SLC66A1 SH3PXD2B SERGEF HAPLN3	6.81e-06	179	114	6	42f3c040f504a91cc69292d39d22b5715c12526f
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPIB MAP3K20 SLC66A1 SH3PXD2B SERGEF HAPLN3	6.81e-06	179	114	6	063c05753ef1b4a18bc1ebbcae62c8cd25d11070
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TPSAB1 LXN LMNA ADAMTS7 BACE2 TPSB2	8.22e-06	185	114	6	3fafb1d36c5f98a29d20a5ce5192c83d6f603514
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TPSAB1 LXN LMNA ADAMTS7 BACE2 TPSB2	8.48e-06	186	114	6	de55471dd5c842026b409cfebf67fe32f079a011
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_naive-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LILRB3 MAP3K20 CD163 SH3PXD2B PTX3 MARCO	8.74e-06	187	114	6	3b1439018e265a61d9599e307a202e3c2f60ed32
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_naive\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LILRB3 MAP3K20 CD163 SH3PXD2B PTX3 MARCO	8.74e-06	187	114	6	e99bc27d212c74da37770297122a4b30445ccd0d
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-myeloid\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TPSAB1 CD163 NLRP3 SH3PXD2B LMNA TPSB2	9.29e-06	189	114	6	2aebea7a6c2f83112d7c504b742f2c04b92e459a
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TPSAB1 CD163 EMP3 MARCO TPSB2 LILRB4	9.29e-06	189	114	6	6cdd743bc46e34dc48288dda343309131b6c2d5f
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LILRB3 CD163 NLRP3 EMP3 MARCO LILRB4	9.29e-06	189	114	6	984b5f21e84dd8273d8437ac2a5a9de4e9484b9a
ToppCell	390C-Myeloid-Macrophage-FABP4+_Macrophage_2\|390C / Donor, Lineage, Cell class and subclass (all cells)	LILRB3 CD163 CD5L SLC47A1 MARCO LILRB4	9.29e-06	189	114	6	3b5e1a8d5c1e1fa2124f64f212e9c6b8f1b7d7da
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_immature_monocyte2_(4)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CD163 NLRP3 CD5L CD163L1 MARCO LILRB4	9.57e-06	190	114	6	e5625feb21915d4545cfad2659745ef180efcb1f
ToppCell	Children_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PRSS36 CD163 NLRP3 SH3PXD2B LMNA CD163L1	9.57e-06	190	114	6	2d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LXN PRSS36 CD163 FCGRT ZNF197 ATM	9.57e-06	190	114	6	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	wk_20-22-Endothelial-Lymph_endothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CFI PKHD1L1 UNC5A PTX3 HAPLN3 BACE2	9.86e-06	191	114	6	631f95fd80dd3678b5b2ef201abf7fe646049af6
ToppCell	wk_08-11-Mesenchymal-Mesothelial-intermediate_mesothelial\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	CA11 CFI PKHD1L1 CLDN16 SCTR ALOX15	1.02e-05	192	114	6	ac9e5288ecd4b1e142f2e15a1fcd11c8eb9e15cd
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A17 ADAMTS6 CD163L1 SCTR SLC47A1 DSEL	1.02e-05	192	114	6	025fac36b862f9ca7f96fb4a1946c44ba7cbc382
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LILRB3 CD163 NLRP3 EMP3 MARCO LILRB4	1.02e-05	192	114	6	62eac1b8aed4fb924946b58c0237313f697a0136
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	CD163 SH3PXD2B CD5L CD163L1 MARCO LILRB4	1.05e-05	193	114	6	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	3'-Broncho-tracheal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TPSAB1 MAS1L LMNA EMP3 BACE2 TPSB2	1.05e-05	193	114	6	349b6428f211c821844b11428d53de52be8a8f05
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TPSAB1 CD163 FCGRT CSNK2B MARCO TPSB2	1.05e-05	193	114	6	2a32f749224942974f45af5c0937609c5f2e7664
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TPSAB1 NLRP3 PTX3 EMP3 TPSB2 LILRB4	1.05e-05	193	114	6	891c0d4119a1c090b8230d00f9f69997850cab8c
ToppCell	Macrophages-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	LILRB3 CD163 FCGRT EMP3 MARCO LILRB4	1.05e-05	193	114	6	642f8f20e5a35a4b5d1fc8d3f1e3b9b83a37a654
ToppCell	390C-Myeloid-Monocyte-CD14+_Monocyte\|390C / Donor, Lineage, Cell class and subclass (all cells)	LILRB3 CD163 NLRP3 FCGRT MARCO LILRB4	1.05e-05	193	114	6	a50ee6110ea272d9d9f41d48bb5d43711cc00a32
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD163 NLRP3 SH3PXD2B FCGRT CD163L1 LILRB4	1.08e-05	194	114	6	ad72be9f6871b334e1f477d868c15e7792fadea5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CD163 NLRP3 FCGRT CD163L1 MARCO LILRB4	1.08e-05	194	114	6	1dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCell	wk_20-22-Endothelial-Lymph_endothelial-Lymphatic_endo\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CFI PKHD1L1 UNC5A PTX3 HAPLN3 BACE2	1.08e-05	194	114	6	640ff8da7084a9486fc2752493b8d8059ecf4ab7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRSS36 CD163 SH3PXD2B FCGRT CD163L1 LILRB4	1.08e-05	194	114	6	45708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCell	21-Trachea-Immune-Hematopoietic,_Macrophage\|Trachea / Age, Tissue, Lineage and Cell class	CD163 NLRP3 CD5L CD163L1 MARCO LILRB4	1.08e-05	194	114	6	3c4ac5f91b10802990b84db3406f5e71f8ee8b74
ToppCell	(2)_Mono_macro\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	LILRB3 CD163 NLRP3 EMP3 MARCO LILRB4	1.08e-05	194	114	6	7c05525614ee8cdfcbf22cce9146a8e73af7d14e
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LILRB3 CD163 NLRP3 SH3PXD2B CD163L1 LILRB4	1.11e-05	195	114	6	f289a44010788853d7726d4b5aa75f3c62186c08
ToppCell	IPF-Myeloid\|IPF / Disease state, Lineage and Cell class	CD163 SH3PXD2B FCGRT CD163L1 EMP3 MARCO	1.11e-05	195	114	6	fdeb958aeaa00f3fc25c4e59efbbc6f4a572c9ce
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-Myeloid-Monocytes\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LILRB3 CD163 NLRP3 EMP3 MARCO LILRB4	1.11e-05	195	114	6	aa3914e277918299dc7d2995c0c72288462ad43d
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LILRB3 CD163 NLRP3 FCGRT MARCO LILRB4	1.11e-05	195	114	6	9168267a799bbd4111b1227754ab8173ac1a4714
ToppCell	390C-Myeloid-Monocyte\|390C / Donor, Lineage, Cell class and subclass (all cells)	LILRB3 CD163 NLRP3 FCGRT MARCO LILRB4	1.11e-05	195	114	6	6f09bfd6394c10c90c23d130a18941bf490e1a8f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CD163 NLRP3 FCGRT CD163L1 MARCO LILRB4	1.11e-05	195	114	6	34a9462f4e843f3065cc58c17ad71c1b5b836ae1
ToppCell	control-Myeloid-Non-resident_Macrophage\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LILRB3 CD163 NLRP3 EMP3 MARCO LILRB4	1.14e-05	196	114	6	646a8d47dddffdfd2d8a62245ea6cd49f9510a1a
ToppCell	Monocytes\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	LILRB3 PRSS36 CD163 FCGRT MARCO LILRB4	1.14e-05	196	114	6	ab0a8f5f388c9794d7f41f99fb0a5f2fd6fff6b3
ToppCell	390C-Myeloid\|390C / Donor, Lineage, Cell class and subclass (all cells)	TPSAB1 CD163 LMNA MARCO TPSB2 LILRB4	1.14e-05	196	114	6	5b690062db162e9ddd1a32b1be4d10f5f99c9407
ToppCell	Skin-Leukocytes\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	TPSAB1 CD163 NLRP3 EMP3 TPSB2 LILRB4	1.14e-05	196	114	6	e327a377c70d17912f5fd2a3529f4e88b147c6c7
ToppCell	(3)_MNP\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	LILRB3 CD163 NLRP3 FCGRT MARCO LILRB4	1.14e-05	196	114	6	c79403da5443710a6caf035a279e42bc324b27c9
ToppCell	ILEUM-non-inflamed-(3)_Resident_macrophages\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	CD163 NLRP3 SH3PXD2B FCGRT CD163L1 LILRB4	1.18e-05	197	114	6	3af24354b6a93c7d105b9fa6549cf215107b9203
ToppCell	(6)_Macrophage\|World / shred on Cell_type and subtype	LILRB3 CD163 SH3PXD2B CD163L1 MARCO LILRB4	1.18e-05	197	114	6	010b275d4da4a896175ad7fbaa96d1dc11a0b744
ToppCell	Bronchial-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intermediate\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LILRB3 CD163 NLRP3 SH3PXD2B CD163L1 LILRB4	1.18e-05	197	114	6	e2983ae16c72371fbf0e5c123de9f4d900724e5e
ToppCell	NS-control-d_0-4-Myeloid-Non-resident_Macrophage\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LILRB3 CD163 NLRP3 EMP3 MARCO LILRB4	1.18e-05	197	114	6	496a1115071a1be6928786192de49f3adf197dfb
ToppCell	NS-moderate-d_07-13-Myeloid-Non-resident_Macrophage\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LILRB3 CD163 NLRP3 EMP3 MARCO LILRB4	1.18e-05	197	114	6	774a5053f43ac7d614c127ae7363d32a3a194f63
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid-LYVE1+_Macrophage\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LILRB3 CD163 NLRP3 EMP3 MARCO LILRB4	1.18e-05	197	114	6	555ea43eccc3eb22be230c27e13d8b3b64c2a61f
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CD163 LMNA FCGRT EMP3 MARCO LILRB4	1.18e-05	197	114	6	9c8c1ce8ed69b3c2b12ecca349ac1901f66b46ab
ToppCell	(7)_MNP\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	LILRB3 CD163 CD5L FCGRT MARCO LILRB4	1.18e-05	197	114	6	6790346736946984cc80d67668523ba70ab0b380
ToppCell	distal-Hematologic-Interstitial_Macrophage-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LILRB3 CD163 NLRP3 MARCO SORL1 LILRB4	1.18e-05	197	114	6	3b859c3bbb71858b97ce670bd507e67c377b88eb
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LILRB3 MAP3K20 CD163 NLRP3 EMP3 MARCO	1.21e-05	198	114	6	dc59442e6a5127d3071a036c206732a21e456a17
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MAP3K20 CD163 NLRP3 LMNA FCGRT LILRB4	1.21e-05	198	114	6	c1fe38594bd6292fcc60bdbb563376b454731d00
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 CD163 NLRP3 CD163L1 TPSB2 LILRB4	1.21e-05	198	114	6	af682919a874d60f579e854c274dc47063015ea9
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LILRB3 CD163 NLRP3 FCGRT MARCO LILRB4	1.21e-05	198	114	6	94e2567f057b2c455a9656b121321a28e7cb1d2b
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LILRB3 CD163 NLRP3 FCGRT MARCO LILRB4	1.21e-05	198	114	6	f3a12a7e23bb4ff6e82fee675dbc090d99587f69
ToppCell	NS-control-d_0-4-Myeloid\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	LILRB3 CD163 NLRP3 EMP3 MARCO LILRB4	1.21e-05	198	114	6	846852943a8ff60f746fd49498240e25ca1c1b09
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_macrophage\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BACE1 CD163 CD5L FCGRT CD163L1 MARCO	1.21e-05	198	114	6	9aaff68107ae4542f904b142d23669f2fcd557ac
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	BACE1 CD163 CD5L FCGRT CD163L1 MARCO	1.21e-05	198	114	6	5aaf3861c53763cf09bb628c9d2eabb6a7277021
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MAP3K20 CD163 NLRP3 LMNA FCGRT LILRB4	1.21e-05	198	114	6	bfc15de70a7577a2860b53e1e6826a7b5ad23040
ToppCell	mild-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LILRB3 CD163 NLRP3 FCGRT MARCO LILRB4	1.25e-05	199	114	6	d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCell	distal-Hematologic-Interstitial_Macrophage-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LILRB3 CD163 NLRP3 SH3PXD2B EMP3 LILRB4	1.25e-05	199	114	6	e25a67a196f226b60b4aa0ff0cf4471d66333445
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LILRB3 CD163 NLRP3 CD5L CD163L1 MARCO	1.25e-05	199	114	6	98c0d57c247d39bc771d81f4387f8dd01222628e
ToppCell	COPD-Myeloid-Macrophage\|COPD / Disease state, Lineage and Cell class	CD163 NLRP3 SH3PXD2B LMNA CD163L1 LILRB4	1.25e-05	199	114	6	4b9c53fb4f44190d2f6ad4d52b13be01ebe4955e
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	LILRB3 CD163 ANGPT4 SLC47A1 MARCO LILRB4	1.25e-05	199	114	6	7648860058eec66019b574ad840d6f5cfa4476d9
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LILRB3 CD163 NLRP3 FCGRT MARCO LILRB4	1.25e-05	199	114	6	c4fc638a8dad3a9b77634e8912a9326c8a2f11f5
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CD163 CD5L FCGRT CD163L1 MARCO LILRB4	1.25e-05	199	114	6	e1066e638af83ba5e89c7cabb8ad00b6bcdee5f4
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PGM2L1 OXTR BSG PTX3 PKD1 EMP3	1.25e-05	199	114	6	e09bd3153dd60d06584707b259c78375b47415c8
ToppCell	Bronchus_Control_(B.)-Immune-TX-MoAM-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	LILRB3 PRSS36 CD163 FCGRT CD163L1 MARCO	1.25e-05	199	114	6	fb63885273d906a85fef178d859d20a311eb8a72
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	LILRB3 CD163 NLRP3 FCGRT MARCO LILRB4	1.25e-05	199	114	6	97af159fa3a5533ec3d45331fb80c6da8a715aa5
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-Myeloid\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 LILRB3 CD163 NLRP3 TPSB2 LILRB4	1.25e-05	199	114	6	41d240d44bd6cc301a7879cacee104c874b4ba2c
Computational	Genes in the cancer module 27.	LILRB3 PRSS12 CFI CD163 CD5L OXTR FCGRT TMPRSS2 CNTFR LILRB4	1.18e-04	355	72	10	MODULE_27
Computational	Serine proteases.	TPSAB1 PRSS12 CFI TMPRSS2	1.27e-04	39	72	4	MODULE_109
Disease	kallikrein-7 measurement	CD163 CD163L1	1.32e-04	5	108	2	EFO_0008195
Disease	ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 2	RYR2 LMNA	1.32e-04	5	108	2	C1832931
Disease	congenital muscular dystrophy (implicated_via_orthology)	LMNA DYNC1H1	1.97e-04	6	108	2	DOID:0050557 (implicated_via_orthology)
Disease	tryptase beta-2 measurement	TPSAB1 TPSB2	4.70e-04	9	108	2	EFO_0008306
Disease	arrhythmogenic right ventricular cardiomyopathy (is_implicated_in)	RYR2 LMNA	5.86e-04	10	108	2	DOID:0050431 (is_implicated_in)
Disease	waist-hip ratio, high density lipoprotein cholesterol measurement	DAGLB NHLRC2	5.86e-04	10	108	2	EFO_0004343, EFO_0004612
Disease	Tachycardia, Ventricular	RYR2 LMNA	7.14e-04	11	108	2	C0042514
Disease	Connective Tissue Diseases	TPSAB1 PKD1	1.01e-03	13	108	2	C0009782
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	LATS1 PKD1	1.17e-03	14	108	2	DOID:898 (implicated_via_orthology)
Disease	creatine kinase measurement	CD163 CD163L1 SAMD4A	1.34e-03	59	108	3	EFO_0004534
Disease	basophil measurement	TPSAB1 ABCC1 TPSB2	1.40e-03	60	108	3	EFO_0803539
Disease	word reading	NLRP3 ATXN8OS SORL1	1.77e-03	65	108	3	EFO_0005300
Disease	Congenital Fiber Type Disproportion	MAP3K20 LMNA	1.95e-03	18	108	2	C0546264
Disease	serum zinc measurement	ADAMTSL1 FNTB	2.18e-03	19	108	2	EFO_0005268
Disease	melanoma	LXN CD163L1 MAP3K9 ADAMTS20 ATM	2.22e-03	248	108	5	C0025202
Disease	urticaria	TPSAB1 TPSB2	2.42e-03	20	108	2	EFO_0005531
Disease	otitis media (implicated_via_orthology)	SH3PXD2B LMNA	2.92e-03	22	108	2	DOID:10754 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WNQGGDWIDLVVAVC	USH1C	526	Q9Y6N9
CKNEAGTDAWFWAGE	BHLHB9	101	Q6PI77
GFWLGEQLVCWQAGT	BACE1	321	P56817
EFSDGFWTGSQLACW	BACE2	331	Q9Y5Z0
VTGRWTLGQVVCDFW	HTR1B	111	P28222
VATWLWVANDENCGI	ANAPC11	11	Q9NYG5
NVTYVWGVVSWGENC	CFI	536	P05156
LWWECVTNAFDGIRT	CLDN16	46	Q9Y5I7
TGWWFNECGLANLNG	ANGPTL5	331	Q86XS5
QKGQWGTVCDDGWDI	CD5L	41	O43866
FWGLVNAAWSLCAVG	CA11	51	O75493
WCGGEQTWQCILSAL	DNHD1	2146	Q96M86
QGQWGTVCDDGWNTT	CD163L1	66	Q9NR16
KFQERWGTICDDGWN	CD163L1	171	Q9NR16
WGTICDDGWNLNTAA	CD163L1	176	Q9NR16
QGRWGTVCDDGWNSK	CD163L1	601	Q9NR16
RWVAGEWGECSAQCG	ADAMTS10	1006	Q9H324
IWDCFTPCGEWQAGD	ADAMTS20	1201	P59510
RWVTGDWGQCSAQCG	ADAMTS6	1021	Q9UKP5
WAVGNWSQCSVTCGE	ADAMTS7	946	Q9UKP4
WVVVFAATWCNGSIF	SLC16A2	101	P36021
FLIAGSWANDVRCWE	RAE1	56	P78406
SWANDVRCWEVQDSG	RAE1	61	P78406
QWAISQASQGGEGTW	RBM10	411	P98175
AEELCQLGQAGFWWL	DNAJC14	241	Q6Y2X3
GQWGTVCDDGWTELN	PRSS12	406	P56730
FINGQWGTICDDGWT	PRSS12	516	P56730
DLVWKAQNTWGCGNS	LMNA	511	P02545
LSQDCAVSGDEGWWT	MAP3K10	46	Q02779
IFQLNSAWWCDNGIT	SPACA5	76	Q96QH8
GADCGIQWWNAVFIM	LYSMD4	211	Q5XG99
EEGLDWCNAGWLQDA	HAPLN3	206	Q96S86
SNGEVQCWALWPDDS	NPSR1	191	Q6W5P4
FVGGRWGTVCDDSWN	HHIPL1	691	Q96JK4
WGTVCDDSWNISGAA	HHIPL1	696	Q96JK4
GYTQLCDWWSVGVIL	LATS1	926	O95835
WGNSVTIWCQGTLEA	LILRB4	41	Q8NHJ6
SGSIQWIWDVLGECA	SLC66A1	16	Q6ZP29
DSGGWEVQDQCTRIW	ATXN8OS	126	P0DMR3
WGGENLEISFRVWQC	GALNT2	331	Q10471
SAEGWWEQESNCQDG	HERC1	3716	Q15751
LCVEWAFSSWGQCNG	ADAMTSL1	1606	Q8N6G6
GEAEPCGAWVWENQV	FCGRT	66	P55899
IEECVEPWNGSWNDN	PGM2L1	206	Q6PCE3
QRADGSWEGSWGVCF	LSS	571	P48449
LKDDAWFCNWISVQG	ALOX15	71	P16050
IPSWNWDTGDNIICF	KCNU1	461	A8MYU2
ASGENVTLLCQSWWQ	LILRB3	336	O75022
SWNCLEDFDQIFWGQ	ALOX12	196	P18054
ADGVFDCWAVFIQPW	OXTR	181	P30559
GVSSCWFLTAEGNEW	NHLRC2	631	Q8NBF2
ICWFSQRAGWTVFAE	MAS1L	6	P35410
TACWATGWGDVQEAD	PRSS36	171	Q5K4E3
WGGENLEISFRIWQC	GALNT1	316	Q10472
IEGKSWSGEFFTCNW	EFCAB5	751	A4FU69
CGVSEWQLEEAQVFW	ATM	2286	Q13315
VDVGSLCWGWFSVAA	CDHR2	856	Q9BYE9
NISAWWNFGSLLGAC	MT-CYB	26	P00156
VLWTGWFCCVFGDSL	CENPL	156	Q8N0S6
WASLGAAWVADGVQC	DAGLB	111	Q8NCG7
QEWTVFNSWCSQGAD	CLCN5	551	P51795
CGTANWDAAVTWRVN	CNTFR	46	P26992
WWFEGQGPNDTCSQL	BSG	56	P35613
WCEQQLEGGGWTVIQ	ANGPTL6	286	Q8NI99
GWWFDACGLSNLNGV	ANGPT4	451	Q9Y264
EVSWISWFCGLRGNE	CSNK2B	6	P67870
STGADGTVCFWQWDL	BRWD1	291	Q9NSI6
GTWGTICDDEWQNSD	MARCO	441	Q9UEW3
IGAWTEDDVYCWVQQ	MAP3K20	336	Q9NYL2
AWVGQEVHLCWESDG	MAN2C1	91	Q9NTJ4
LFEGTAEWIARCQNW	FNTB	221	P49356
FNRCVLNWFGDWSTE	DYNC1H1	3086	Q14204
TWACSNVSENGWLKA	EMP3	51	P54852
ENLWLQCEWGSCSFV	HINFP	11	Q9BQA5
VKVQEEWGTVCNNGW	CD163	66	Q86VB7
DVGLQEDTTGEACWW	RYR2	146	Q92736
EGQLGECAQWLKWTG	DSEL	516	Q8IZU8
SQVSGDEGWWTGQLN	MAP3K9	86	P80192
ETCWNSDQGPSQWVT	NR2C2AP	36	Q86WQ0
FVQLGDEAWLVACAW	PKD1	1391	P98161
VGQTGWGQVAEQSWD	PKN3	341	Q6P5Z2
CGTWNSEEGLTSLWV	PTX3	271	P26022
FCSADGSDPLWDWNV	ABCC1	6	P33527
WVACGYIIWQNSTED	LXN	141	Q9BS40
LWGLCSLAADGIWNQ	NLRP3	466	Q96P20
WFWTRVEACVEGDVN	GPRASP1	616	Q5JY77
EQCFSGGIDATIQWW	STRN3	546	Q13033
SNGNCINSIWWCDFD	SORL1	1086	Q92673
CFQNEKVTAIWSGWT	SERGEF	261	Q9UGK8
WLQAGVVSWGEGCAQ	TPSAB1	236	Q15661
WLQAGVVSWGEGCAQ	TPSB2	236	P20231
AIGQWDLVCDLGWQV	SLC22A17	86	Q8WUG5
VVFWKTGQGCEWTEG	SHPK	96	Q9UHJ6
VQGDLQAAQLWAGCW	SHROOM2	481	Q13796
ECVWWVEPGAGVFQF	SPIB	186	Q01892
QGWWTGEGEFNFSEV	SCRN1	211	Q12765
GGWSLECLQDWASFL	SLC47A1	246	Q96FL8
WVSGLAQEARGSCNW	TMEM270	46	Q6UE05
CWVTGWSQVKQRFSA	PRSS45P	116	Q7RTY3
DECGKVFNWWSQLTN	ZNF678	156	Q5SXM1
CEWQVLASQWGNETD	ZNF197	301	O14709
EQLCWISGWGATEEK	TMPRSS2	376	O15393
DKDTGEWLGAWNNCF	NHLRC3	241	Q5JS37
EWLGAWNNCFTEEGP	NHLRC3	246	Q5JS37
QVGILAGWFKGWNEC	SAMD4B	6	Q5PRF9
AGWFKGWNECEQTVA	SAMD4B	11	Q5PRF9
IWGNGFIVLVNCIDW	TAS2R9	21	Q9NYW1
QFVSWNQEGWKTSLC	TUBE1	371	Q9UJT0
FEVREKNSSGWWFCQ	SH3PXD2B	876	A1X283
KNSSGWWFCQVLSGA	SH3PXD2B	881	A1X283
EDVGCWDINANASIW	SCTR	281	P47872
WQTGAAQDCSWFLAV	SERINC4	211	A6NH21
FWGPECNSLQFVWED	SMOX	376	Q9NWM0
NFQVEGRTRCWVTGW	PRSS42P	191	Q7Z5A4
LVSCFFQEGWVLSWN	TECPR2	291	O15040
LTTWNCQKGAEWVNG	PKHD1L1	2651	Q86WI1
CKLWVWQVEGDGQSF	UNC5A	706	Q6ZN44
TCWWSQPDFRAIGDF	WNT3A	216	P56704
GEFPVSVWVTAADCW	TMEM130	101	Q8N3G9
PDDCSELWLWNVQTG	WDR26	421	Q9H7D7
LESRQAWQWGVCGDN	WNT9B	151	O14905
FWRCWFNGIVEENDS	TMEM182	56	Q6ZP80
QVGVLAGWFKGWNEC	SAMD4A	6	Q9UPU9
AGWFKGWNECEQTVA	SAMD4A	11	Q9UPU9
DVWLSGGNDLCVWNR	WDR41	146	Q9HAD4
QWCGSQELWFGKTCE	ZNF662	116	Q6ZS27