Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainCRAL_TRIO

PRUNE2 SEC14L5 SEC14L1

2.77e-0521533PF00650
Domain-

PRUNE2 SEC14L5 SEC14L1

3.67e-05235333.40.525.10
DomainSEC14

PRUNE2 SEC14L5 SEC14L1

4.75e-0525533SM00516
DomainCRAL_TRIO

PRUNE2 SEC14L5 SEC14L1

6.01e-0527533PS50191
DomainCRAL-TRIO_dom

PRUNE2 SEC14L5 SEC14L1

6.72e-0528533IPR001251
DomainPRELI_MSF1

SEC14L5 SEC14L1

1.18e-046532PS50904
DomainPRELI

SEC14L5 SEC14L1

1.18e-046532PF04707
DomainPRELI/MSF1_dom

SEC14L5 SEC14L1

1.18e-046532IPR006797
DomainCRAL_TRIO_N

SEC14L5 SEC14L1

4.27e-0411532PF03765
DomainCRAL-bd_toc_tran

SEC14L5 SEC14L1

5.12e-0412532IPR001071
DomainCRAL_TRIO_N

SEC14L5 SEC14L1

5.12e-0412532SM01100
DomainCRAL/TRIO_N_dom

SEC14L5 SEC14L1

8.10e-0415532IPR011074
DomainGOLD_dom

SEC14L5 SEC14L1

1.31e-0319532IPR009038
DomainGOLD

SEC14L5 SEC14L1

1.31e-0319532PS50866
Domainzf-C2H2_6

ZFP90 ZNF141 ZNF320 ZNF429 ZFP14

1.93e-03314535PF13912
DomainKRAB

ZFP90 ZNF141 ZNF320 ZNF429 ZFP14

3.40e-03358535PS50805
DomainKRAB

ZFP90 ZNF141 ZNF320 ZNF429 ZFP14

3.40e-03358535PF01352
DomainKRAB

ZFP90 ZNF141 ZNF320 ZNF429 ZFP14

3.86e-03369535SM00349
DomainKRAB

ZFP90 ZNF141 ZNF320 ZNF429 ZFP14

3.91e-03370535IPR001909
DomainABC_transporter_CS

ABCC4 ABCA2

6.33e-0342532IPR017871
DomainF-box-like

FBXW12 BTRC

6.93e-0344532PF12937
DomainAAA+_ATPase

ABCC4 ABCA2 DYNC2H1

7.94e-03144533IPR003593
DomainAAA

ABCC4 ABCA2 DYNC2H1

7.94e-03144533SM00382
DomainABC_tran

ABCC4 ABCA2

8.20e-0348532PF00005
DomainABC_TRANSPORTER_2

ABCC4 ABCA2

8.20e-0348532PS50893
DomainABC_TRANSPORTER_1

ABCC4 ABCA2

8.53e-0349532PS00211
DomainABC_transporter-like

ABCC4 ABCA2

8.87e-0350532IPR003439
DomainFBOX

FBXW12 BTRC

9.57e-0352532SM00256
Pubmed

Critical role for IL-1β in DNA damage-induced mucositis.

IL1B BTRC

7.36e-06355224469832
Pubmed

Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2.

PRKD2 BTRC

7.36e-06355221173164
Pubmed

The lipid-binding SEC14 domain.

SEC14L5 SEC14L1

2.45e-05555217428729
Pubmed

USP13 promotes breast cancer metastasis through FBXL14-induced Twist1 ubiquitination.

USP13 BTRC

2.45e-05555236732432
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

PRKD2 CRNKL1 USP13 ABCA2 ANK3 OTOF CCT7 CHPF COG4 BTRC

2.94e-051285551035914814
Pubmed

Interaction of constitutive photomorphogenesis 1 protein with protein-tyrosine phosphatase 1B suppresses protein-tyrosine phosphatase 1B activity and enhances insulin signaling.

PTPN1 IL1B

3.67e-05655223439647
Pubmed

F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2.

MAPK6 BTRC

6.83e-05855234703820
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

TRHDE ABCA2 IDUA CHPF

1.35e-0416455432409323
Pubmed

TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.

FBXW12 BTRC

1.89e-041355233962073
Pubmed

Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.

IL10RB IL1B

2.21e-041455218715339
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

PRKD2 CRYBG2 SHROOM3 ABCA2 POLRMT ARHGAP17 IDUA CHPF

3.28e-04110555835748872
Pubmed

Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters.

BEST1 ABCC4

3.70e-041855231791063
Pubmed

Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.

ZFP90 ZNF429

4.58e-04205527479878
Pubmed

Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.

ZFP90 ZNF429

4.58e-04205522542606
Pubmed

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

NAF1 CCT7

5.06e-042155225467444
Pubmed

Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.

ABCC4 ABCA2

5.06e-042155223137377
Pubmed

An unappreciated role for RNA surveillance.

CRNKL1 CPXM1 COG4

5.75e-0410255314759258
Pubmed

Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development.

CCT7 CHPF

6.63e-042455218816836
Pubmed

Secretory pathway calcium ATPase 1 (SPCA1) controls mouse neural tube closure by regulating cytoskeletal dynamics.

SHROOM3 ATP2C1

9.70e-042955230228103
Pubmed

POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.

CRNKL1 SHROOM3 SETX CCT7

9.76e-0427755430745168
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

PRKD2 USP13 DYNC2H1 SF3A1 NAF1 CCT7 BTRC

9.99e-04100555719615732
Pubmed

A human MAP kinase interactome.

SETX ANK3 ARHGAP17 MAPK6 COG4

1.02e-0348655520936779
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PRUNE2 ATP2C1 DYNC2H1 LCMT2 SEC14L1

1.09e-0349355515368895
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

PRUNE2 SHROOM3 APEX2 MAPK6 IDUA

1.12e-0349655531343991
Pubmed

VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.

ARFGAP2 ARHGAP17 CCT7 COG4

1.13e-0328855423383273
Pubmed

Role of inflammation gene polymorphisms on pain severity in lung cancer patients.

IL10RB IL1B

1.26e-033355219773451
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

PTPN1 ARFGAP2 SHROOM3 SETX ANK3 CCT7

1.39e-0377755635844135
Pubmed

Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

IL10RB IL1B

1.49e-033655220811626
Pubmed

A Novel Mechanism for NF-κB-activation via IκB-aggregation: Implications for Hepatic Mallory-Denk-Body Induced Inflammation.

PTPN1 POLRMT

1.58e-033755232912968
GeneFamilySEC14 family|PRELI domain containing

SEC14L5 SEC14L1

7.12e-0564021063
GeneFamilySEC14 family|PRELI domain containing

SEC14L5 SEC14L1

7.12e-0564021295
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZFP90 ZNF141 ZNF320 ZNF788P ZNF429 ZNF888 ZNF525 ZFP14

1.48e-0471840828
GeneFamilyWD repeat domain containing|F-box and WD repeat domain containing

FBXW12 BTRC

2.59e-0411402559
CoexpressionHERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_UP

N4BP2L1 ZFP90 PDZK1IP1 BTRC

1.41e-0571544M1188
ToppCellhematopoetic_progenitors-CD34+_MEP_1|World / Lineage and Cell class

ABCC4 ATP2C1 CPXM1 IL1B FREM1

3.83e-0619155591327184ca40bfb8c9e904991b1be503aaccd7bc
ToppCellTCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma|TCGA-Uterus / Sample_Type by Project: Shred V9

ABCC4 SHROOM3 ZNF320 ZNF888

3.64e-051515542810bfa01bd3016aeba29735eb4a9284792e8aac
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRNKL1 BEST1 OTOF ARHGAP17

4.79e-0516255493bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Adult / Lineage, Cell type, age group and donor

ABCC4 SHROOM3 ANK3 HID1

4.90e-05163554e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCellhealthy_donor-Myeloid-Monocytic-SC_&_Eosinophil|healthy_donor / Disease condition, Lineage, Cell class and subclass

ABCC4 CPXM1 VWDE FREM1

7.52e-051825546bd6c32c48fecd6d03ac8a09e405b3b99bdc12ae
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

POLRMT ZNF525 ZFP14 MAPK6

8.01e-051855547925519b855f76444a0b57382ce35d89457b0b14
ToppCell(8)_CD34_progenitor|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

CPXM1 EPX IL1B FREM1

8.18e-05186554e69a986b8618effd61875fda528a2e44aab11868
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 ABCC4 SHROOM3 ANK3

8.18e-05186554b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell(8)_CD34_progenitor|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

CPXM1 EPX IL1B FREM1

8.18e-05186554943c604a7cd873faf510096d094100512ba2d6bc
ToppCellCOVID_vent-Myeloid-Monocytic-SC_&_Eosinophil|COVID_vent / Disease condition, Lineage, Cell class and subclass

CPXM1 EPX IL1B FREM1

8.70e-051895542157a2d40613f7d5ce2e7dbd266df441e449cdaf
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRHDE PRUNE2 SHROOM3 ANK3

9.43e-051935543866667dd221612589ae50f5c52f73a183a49ce6
ToppCellerythropoietic-CD34+_Pro-erythroblast|World / Lineage and Cell class

ABCC4 ATP2C1 CPXM1 IL1B

9.62e-05194554cd12d01f6f2f12bbc33ed523bc678d3965074974
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

USP13 ABCC4 SHROOM3 ANK3

9.62e-0519455497534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 ABCC4 SHROOM3 ANK3

9.62e-051945547002937e8903e037332a215d00fbc7c7843b33f2
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRUNE2 SHROOM3 PDZK1IP1 HID1

9.82e-05195554c5f33b420c9ac14dc67fea632b8c2bc2442cbf3d
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-Goblet_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRUNE2 SHROOM3 PDZK1IP1 HID1

9.82e-05195554219c5d0cde7f6082755154f54db221413ec555cb
ToppCellSevere-Plasmablast|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ABCC4 HID1 CHPF SEC14L1

1.02e-041975541089aa7991812378668d0f3d57f8000e6245a713
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PRUNE2 ABCA2 ANK3 SEC14L5

1.02e-0419755482b8e22317cad6d3786bd70d91107007c0ccd7cd
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP13 ABCC4 SHROOM3 ANK3

1.06e-041995542dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCellMacroglial-Oligodendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

PRUNE2 ABCA2 ANK3 SEC14L5

1.08e-042005544dbac2f2587e87ca5a0622f50439bb5447e93c7f
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

TRHDE DYNC2H1 CPXM1 FREM1

1.08e-042005549b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PRUNE2 ABCA2 ANK3 SEC14L5

1.08e-042005540bfd41c12887479ceb62c3db0a3c3ba5007eb62b
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PRUNE2 ABCA2 ANK3 SEC14L5

1.08e-04200554159377d904394d91e09913131e9a93e08189955a
ToppCellSigmoid-Dendritic_cell-cDC1|Dendritic_cell / Region, Cell class and subclass

ANK3 ZNF429 ZNF888 IDUA

1.08e-0420055409deb831fc2c8a8867cc850f3aa094a5e48489ff
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PRUNE2 ABCA2 ANK3 SEC14L5

1.08e-04200554d30316836494f33ca46d4e415fd2ed179e9cb5ee
ToppCellMacroglial-Oligodendrocytes-OPALIN---|Macroglial / cells hierarchy compared to all cells using T-Statistic

PRUNE2 ABCA2 ANK3 SEC14L5

1.08e-042005541314664c1721e9ecb1e2c3482a039044b0fe50a9
ToppCellMacroglial-Oligodendrocytes-OPALIN-|Macroglial / cells hierarchy compared to all cells using T-Statistic

PRUNE2 ABCA2 ANK3 SEC14L5

1.08e-042005548b229f095fc113aecfc94b64862a9e0fdcc363ce
ToppCellMacroglial-Oligodendrocytes-OPALIN----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

PRUNE2 ABCA2 ANK3 SEC14L5

1.08e-04200554272909f4354f3ae22e2b2f8f35970e6b0e92cfe2
ToppCellMacroglial-Oligodendrocytes-OPALIN--|Macroglial / cells hierarchy compared to all cells using T-Statistic

PRUNE2 ABCA2 ANK3 SEC14L5

1.08e-0420055426b989e30bbbaf30904ced03f6aae3dea25c732c
ToppCellMacroglial-Oligodendrocytes-OPALIN|Macroglial / cells hierarchy compared to all cells using T-Statistic

PRUNE2 ABCA2 ANK3 SEC14L5

1.08e-042005545f75a9b8bcd49d9bbb1e9ce2de730eaec96369ca
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PRUNE2 ABCA2 ANK3 SEC14L5

1.08e-04200554829978708463a7459fe1041bd90196775bc4b531
Diseasechronic kidney disease (implicated_via_orthology)

SHROOM3 IL1B

2.07e-0412532DOID:784 (implicated_via_orthology)
Diseasecardiotoxicity, response to anthracycline-based chemotherapy

PRUNE2 POLRMT

2.84e-0414532EFO_0005257, EFO_1001482
Diseasefrailty measurement

ANK3 MAPK6

7.82e-0423532EFO_0009885
Diseaseacute myocardial infarction (biomarker_via_orthology)

ARHGAP17 IL1B

1.16e-0328532DOID:9408 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
FEEDGWVTDHFSQTP

TRHDE

311

Q9UKU6
EEEFNDYEANDPWVQ

COG4

636

Q9H9E3
DPEAFTENGEWAIQH

CHRNG

196

P07510
FEQWSESDQVEFVEH

BTRC

141

Q9Y297
EEQDADPWFQVDAGH

CPXM1

166

Q96SM3
NPFGEDDDDFETNWI

BEST1

296

O76090
DSDFFTEHTQPPAWD

ARFGAP2

151

Q8N6H7
DHWDAVNLECFEEDP

APEX2

206

Q9UBZ4
AFHGWNEFDISEDEP

ATP2C1

56

P98194
FIFEEEPIFFDTWDN

IL1B

96

P01584
EPIFFDTWDNEAYVH

IL1B

101

P01584
EFFPNHQWVKEETQE

PTPN1

326

P18031
FHLEEPNIAFWTEAQ

KIAA1109

4681

Q2LD37
FEDHQAAINNFWVDP

FBXW12

376

Q6X9E4
DWPVHNNFDIDEVQL

MAPK6

366

Q16659
IAFAVNHFWCQEEPE

PDZK1IP1

46

Q13113
QWGQFIDHDLDFSPE

EPX

226

P11678
FEDSFQFVLWDSHEP

FREM1

606

Q5H8C1
ESDDARWEQFAAEHP

PRKD2

831

Q9BZL6
DPFNEHTDEELWNAL

ABCC4

1136

O15439
TPSDEFQFWIEQAHR

DYNC2H1

171

Q8NCM8
EEEVKANPHNYDAWF

CRNKL1

481

Q9BZJ0
WILFDETNFEGDQHI

CRYBG2

1396

Q8N1P7
QWHTFSQSPVEGDDF

ABCA2

876

Q9BZC7
FADENNVFHDPVDGW

ANK3

4186

Q12955
NFETWNEPDHHDFDN

IDUA

176

P35475
AEFADEHSDWVNITF

IL10RB

91

Q08334
TELQFEHLNWDPEEV

SAMD15

536

Q9P1V8
ASFQNFPVESDWDED

RNF103

471

O00237
VHPENEDWTCFEQSA

SEC14L1

116

Q92503
VHPENEDWTCFEQSA

SEC14L5

116

O43304
ELSDFPQEFVWEASH

POLRMT

1016

O00411
ESEFDNFEDWLHTFN

OTOF

1416

Q9HC10
EANQVDWELPASDEH

PRUNE2

1181

Q8WUY3
QHADWFFPEEVEFNV

ARHGAP17

436

Q68EM7
GHANWSQFRFEEETP

INSL6

46

Q9Y581
TQPVEATDDAFWDQF

HID1

21

Q8IV36
SSEVFSVWQDHPDDN

SETX

1086

Q7Z333
RLSEPWEGDFQEDHN

SHROOM3

621

Q8TF72
NEDIADNFEAFVWEP

CCT7

481

Q99832
WHDFVVVETVDFQPN

SF3A1

276

Q15459
PDQSDEWIFPENADH

CFAP20DC

291

Q6ZVT6
EQHGDDFDWFFLVPD

CHPF

186

Q8IZ52
EKDIHNFEFQWQEDE

ZNF525

91

Q8N782
EDHAEDVQQEFFPSW

VWDE

781

Q8N2E2
DFVFQWQEDETNDHE

ZNF320

96

A2RRD8
PNSEWKEHAEADTFF

TBC1D13

246

Q9NVG8
FTQDHWPVQGIEDSF

ZNF141

81

Q15928
IAWDHSFYPFQEEEE

nan

36

Q3C1V9
FVFQWQEDETNGHEA

ZNF888

96

P0CJ79
VVCSHFAEDFWPEQD

ZNF429

76

Q86V71
FEDVAVNFTPDEWAL

ZNF788P

26

Q6ZQV5
VAIDFSQEEWEFLDP

ZFP14

11

Q9HCL3
RVENIEPFDEFEEWH

LCMT2

286

O60294
LDWIFSHPEFEEDSD

USP13

761

Q92995
VDFTQEEWYHVDPAQ

ZFP90

21

Q8TF47
FNEPGEDFTEVHQNW

NAF1

341

Q96HR8
EFNPDFLEEAHEWNQ

N4BP2L1

86

Q5TBK1