Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of mesenchymal cell apoptotic process	PAX8 SYNE1 PAX2	5.61e-06	13	57	3	GO:2001054
GeneOntologyBiologicalProcess	positive regulation of metanephric DCT cell differentiation	PAX8 PAX2	7.50e-06	2	57	2	GO:2000594
GeneOntologyBiologicalProcess	regulation of apoptotic process involved in metanephric collecting duct development	PAX8 PAX2	7.50e-06	2	57	2	GO:1900214
GeneOntologyBiologicalProcess	negative regulation of apoptotic process involved in metanephric collecting duct development	PAX8 PAX2	7.50e-06	2	57	2	GO:1900215
GeneOntologyBiologicalProcess	negative regulation of apoptotic process involved in metanephric nephron tubule development	PAX8 PAX2	7.50e-06	2	57	2	GO:1900218
GeneOntologyBiologicalProcess	regulation of apoptotic process involved in metanephric nephron tubule development	PAX8 PAX2	7.50e-06	2	57	2	GO:1900217
GeneOntologyBiologicalProcess	mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	PAX8 PAX2	7.50e-06	2	57	2	GO:1901147
GeneOntologyBiologicalProcess	apoptotic process involved in metanephric nephron tubule development	PAX8 PAX2	7.50e-06	2	57	2	GO:1900205
GeneOntologyBiologicalProcess	apoptotic process involved in metanephric collecting duct development	PAX8 PAX2	7.50e-06	2	57	2	GO:1900204
GeneOntologyBiologicalProcess	regulation of metanephric DCT cell differentiation	PAX8 PAX2	7.50e-06	2	57	2	GO:2000592
GeneOntologyBiologicalProcess	negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	PAX8 PAX2	7.50e-06	2	57	2	GO:0072305
GeneOntologyBiologicalProcess	regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	PAX8 PAX2	7.50e-06	2	57	2	GO:0072304
GeneOntologyBiologicalProcess	kidney field specification	PAX8 PAX2	7.50e-06	2	57	2	GO:0072004
GeneOntologyBiologicalProcess	pronephric field specification	PAX8 PAX2	7.50e-06	2	57	2	GO:0039003
GeneOntologyBiologicalProcess	pattern specification involved in pronephros development	PAX8 PAX2	7.50e-06	2	57	2	GO:0039017
GeneOntologyBiologicalProcess	regulation of mesenchymal cell apoptotic process	PAX8 SYNE1 PAX2	1.32e-05	17	57	3	GO:2001053
GeneOntologyBiologicalProcess	mesenchymal cell apoptotic process	PAX8 SYNE1 PAX2	1.88e-05	19	57	3	GO:0097152
GeneOntologyBiologicalProcess	metanephric DCT cell differentiation	PAX8 PAX2	2.25e-05	3	57	2	GO:0072240
GeneOntologyBiologicalProcess	mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis	PAX8 PAX2	2.25e-05	3	57	2	GO:0072309
GeneOntologyBiologicalProcess	kidney rudiment formation	PAX8 PAX2	2.25e-05	3	57	2	GO:0072003
GeneOntologyBiologicalProcess	DCT cell differentiation	PAX8 PAX2	2.25e-05	3	57	2	GO:0072069
GeneOntologyBiologicalProcess	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	PAX8 PAX2	4.49e-05	4	57	2	GO:0072108
GeneOntologyBiologicalProcess	negative regulation of mesenchymal cell apoptotic process involved in metanephros development	PAX8 PAX2	4.49e-05	4	57	2	GO:1900212
GeneOntologyBiologicalProcess	regulation of mesenchymal cell apoptotic process involved in metanephros development	PAX8 PAX2	4.49e-05	4	57	2	GO:1900211
GeneOntologyBiologicalProcess	mesenchymal cell apoptotic process involved in nephron morphogenesis	PAX8 PAX2	4.49e-05	4	57	2	GO:1901145
GeneOntologyBiologicalProcess	metanephric nephron tubule formation	PAX8 PAX2	4.49e-05	4	57	2	GO:0072289
GeneOntologyBiologicalProcess	mesenchymal cell apoptotic process involved in metanephros development	PAX8 PAX2	4.49e-05	4	57	2	GO:1900200
GeneOntologyBiologicalProcess	negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	PAX8 PAX2	4.49e-05	4	57	2	GO:0072040
GeneOntologyBiologicalProcess	regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis	PAX8 PAX2	4.49e-05	4	57	2	GO:0072039
GeneOntologyBiologicalProcess	urogenital system development	PAX8 PAX2 PBX1 HOXB13	6.75e-05	79	57	4	GO:0001655
GeneOntologyBiologicalProcess	metanephric distal convoluted tubule development	PAX8 PAX2	7.46e-05	5	57	2	GO:0072221
GeneOntologyBiologicalProcess	metanephric distal tubule development	PAX8 PAX2	7.46e-05	5	57	2	GO:0072235
GeneOntologyBiologicalProcess	negative regulation of somatic stem cell population maintenance	PAX8 PAX2	7.46e-05	5	57	2	GO:1904673
GeneOntologyBiologicalProcess	distal convoluted tubule development	PAX8 PAX2	7.46e-05	5	57	2	GO:0072025
GeneOntologyBiologicalProcess	metanephric tubule formation	PAX8 PAX2	1.12e-04	6	57	2	GO:0072174
GeneOntologyBiologicalProcess	positive regulation of epithelial cell differentiation involved in kidney development	PAX8 PAX2	1.56e-04	7	57	2	GO:2000698
GeneOntologyBiologicalProcess	metanephric collecting duct development	PAX8 PAX2	1.56e-04	7	57	2	GO:0072205
GeneOntologyBiologicalProcess	metanephric nephron tubule epithelial cell differentiation	PAX8 PAX2	1.56e-04	7	57	2	GO:0072257
GeneOntologyBiologicalProcess	metanephric nephron tubule morphogenesis	PAX8 PAX2	1.56e-04	7	57	2	GO:0072282
GeneOntologyBiologicalProcess	negative regulation of apoptotic process involved in morphogenesis	PAX8 PAX2	1.56e-04	7	57	2	GO:1902338
GeneOntologyBiologicalProcess	regulation of metanephric nephron tubule epithelial cell differentiation	PAX8 PAX2	1.56e-04	7	57	2	GO:0072307
GeneOntologyBiologicalProcess	mesenchymal stem cell maintenance involved in nephron morphogenesis	PAX8 PAX2	1.56e-04	7	57	2	GO:0072038
GeneOntologyBiologicalProcess	negative regulation of apoptotic process involved in development	PAX8 PAX2	2.08e-04	8	57	2	GO:1904746
GeneOntologyBiologicalProcess	pattern specification involved in kidney development	PAX8 PAX2	2.08e-04	8	57	2	GO:0061004
GeneOntologyBiologicalProcess	renal system pattern specification	PAX8 PAX2	2.08e-04	8	57	2	GO:0072048
GeneOntologyBiologicalProcess	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	PAX8 PAX2	2.67e-04	9	57	2	GO:0003339
GeneOntologyBiologicalProcess	apoptotic process involved in development	PAX8 PAX2 XKR6	2.98e-04	47	57	3	GO:1902742
GeneOntologyBiologicalProcess	metanephric tubule morphogenesis	PAX8 PAX2	3.33e-04	10	57	2	GO:0072173
GeneOntologyBiologicalProcess	distal tubule development	PAX8 PAX2	3.33e-04	10	57	2	GO:0072017
GeneOntologyBiologicalProcess	pronephros development	PAX8 PAX2	3.33e-04	10	57	2	GO:0048793
GeneOntologyBiologicalProcess	dopaminergic neuron differentiation	FGF20 PAX2 PAX5	3.58e-04	50	57	3	GO:0071542
GeneOntologyBiologicalProcess	morphogenesis of a branching epithelium	DDR1 PAX8 PAX2 PBX1 HOXB13	4.85e-04	236	57	5	GO:0061138
GeneOntologyBiologicalProcess	mesenchymal to epithelial transition involved in metanephros morphogenesis	PAX8 PAX2	4.86e-04	12	57	2	GO:0003337
GeneOntologyBiologicalProcess	collagen-activated tyrosine kinase receptor signaling pathway	COL4A6 DDR1	4.86e-04	12	57	2	GO:0038063
GeneOntologyBiologicalProcess	regulation of nephron tubule epithelial cell differentiation	PAX8 PAX2	5.74e-04	13	57	2	GO:0072182
GeneOntologyBiologicalProcess	regulation of somatic stem cell population maintenance	PAX8 PAX2	5.74e-04	13	57	2	GO:1904672
GeneOntologyBiologicalProcess	collecting duct development	PAX8 PAX2	5.74e-04	13	57	2	GO:0072044
GeneOntologyBiologicalProcess	morphogenesis of a branching structure	DDR1 PAX8 PAX2 PBX1 HOXB13	7.26e-04	258	57	5	GO:0001763
GeneOntologyBiologicalProcess	nephron tubule epithelial cell differentiation	PAX8 PAX2	7.70e-04	15	57	2	GO:0072160
GeneOntologyBiologicalProcess	metanephric renal vesicle morphogenesis	PAX8 PAX2	7.70e-04	15	57	2	GO:0072283
GeneOntologyBiologicalProcess	regulation of apoptotic process involved in morphogenesis	PAX8 PAX2	7.70e-04	15	57	2	GO:1902337
GeneOntologyBiologicalProcess	termination of RNA polymerase II transcription	PCF11 TTF2	8.78e-04	16	57	2	GO:0006369
GeneOntologyBiologicalProcess	branching involved in ureteric bud morphogenesis	PAX8 PAX2 PBX1	8.83e-04	68	57	3	GO:0001658
GeneOntologyBiologicalProcess	regulation of apoptotic process involved in development	PAX8 PAX2	9.94e-04	17	57	2	GO:1904748
GeneOntologyBiologicalProcess	collagen-activated signaling pathway	COL4A6 DDR1	1.12e-03	18	57	2	GO:0038065
GeneOntologyBiologicalProcess	renal vesicle morphogenesis	PAX8 PAX2	1.12e-03	18	57	2	GO:0072077
GeneOntologyBiologicalProcess	ureteric bud morphogenesis	PAX8 PAX2 PBX1	1.13e-03	74	57	3	GO:0060675
GeneOntologyBiologicalProcess	ear development	DDR1 FGF20 PAX8 NAGLU PAX2	1.13e-03	285	57	5	GO:0043583
GeneOntologyBiologicalProcess	regulation of epithelial cell differentiation involved in kidney development	PAX8 PAX2	1.24e-03	19	57	2	GO:2000696
GeneOntologyBiologicalProcess	renal vesicle development	PAX8 PAX2	1.24e-03	19	57	2	GO:0072087
GeneOntologyBiologicalProcess	mesonephric tubule morphogenesis	PAX8 PAX2 PBX1	1.31e-03	78	57	3	GO:0072171
GeneOntologyBiologicalProcess	mesenchymal to epithelial transition	PAX8 PAX2	1.38e-03	20	57	2	GO:0060231
GeneOntologyBiologicalProcess	metanephric nephron tubule development	PAX8 PAX2	1.52e-03	21	57	2	GO:0072234
GeneOntologyBiologicalProcess	cell differentiation involved in metanephros development	PAX8 PAX2	1.67e-03	22	57	2	GO:0072202
GeneOntologyBiologicalProcess	positive regulation of branching involved in ureteric bud morphogenesis	PAX8 PAX2	1.67e-03	22	57	2	GO:0090190
GeneOntologyBiologicalProcess	nephron tubule morphogenesis	PAX8 PAX2 PBX1	1.80e-03	87	57	3	GO:0072078
GeneOntologyBiologicalProcess	metanephric nephron epithelium development	PAX8 PAX2	1.83e-03	23	57	2	GO:0072243
GeneOntologyBiologicalProcess	metanephric nephron morphogenesis	PAX8 PAX2	1.83e-03	23	57	2	GO:0072273
GeneOntologyBiologicalProcess	nephron tubule formation	PAX8 PAX2	1.83e-03	23	57	2	GO:0072079
GeneOntologyBiologicalProcess	nephron epithelium morphogenesis	PAX8 PAX2 PBX1	1.92e-03	89	57	3	GO:0072088
GeneOntologyBiologicalProcess	regulation of branching involved in ureteric bud morphogenesis	PAX8 PAX2	1.99e-03	24	57	2	GO:0090189
GeneOntologyBiologicalProcess	nephron morphogenesis	PAX8 PAX2 PBX1	2.05e-03	91	57	3	GO:0072028
GeneOntologyBiologicalProcess	renal tubule morphogenesis	PAX8 PAX2 PBX1	2.18e-03	93	57	3	GO:0061333
GeneOntologyBiologicalProcess	branching morphogenesis of an epithelial tube	DDR1 PAX8 PAX2 PBX1	2.19e-03	198	57	4	GO:0048754
GeneOntologyBiologicalProcess	animal organ morphogenesis	DDR1 FGF20 PAX8 NAGLU SCN10A SP6 PAX2 PAX5 PBX1 HOXB13	2.29e-03	1269	57	10	GO:0009887
GeneOntologyBiologicalProcess	metanephric tubule development	PAX8 PAX2	2.34e-03	26	57	2	GO:0072170
GeneOntologyBiologicalProcess	negative regulation of stem cell population maintenance	PAX8 PAX2	2.34e-03	26	57	2	GO:1902455
GeneOntologyBiologicalProcess	neuron projection fasciculation	CELSR3 NCAM2	2.71e-03	28	57	2	GO:0106030
GeneOntologyBiologicalProcess	metanephric epithelium development	PAX8 PAX2	2.71e-03	28	57	2	GO:0072207
GeneOntologyBiologicalProcess	axonal fasciculation	CELSR3 NCAM2	2.71e-03	28	57	2	GO:0007413
GeneOntologyBiologicalProcess	metanephros morphogenesis	PAX8 PAX2	2.90e-03	29	57	2	GO:0003338
GeneOntologyCellularComponent	proteasome regulatory particle, lid subcomplex	ADRM1 PSMD13	2.24e-04	8	60	2	GO:0008541
HumanPheno	Potter facies	FGF20 PAX2 PBX1	1.68e-05	13	21	3	HP:0002009
HumanPheno	Facial shape deformation	FGF20 PAX2 PBX1	3.96e-05	17	21	3	HP:0011334
HumanPheno	Beta 2-microglobulinuria	PAX2 PBX1	9.67e-05	4	21	2	HP:0025466
MousePheno	absent uterine horn	PAX8 PAX2	1.01e-05	2	45	2	MP:0009215
MousePheno	absent efferent ductules of testis	PAX8 PAX2	3.03e-05	3	45	2	MP:0004729
Domain	Pax2_C	PAX8 PAX2 PAX5	3.15e-08	3	60	3	IPR022130
Domain	Pax2_C	PAX8 PAX2 PAX5	3.15e-08	3	60	3	PF12403
Domain	PAX	PAX8 PAX2 PAX5	2.61e-06	9	60	3	SM00351
Domain	Paired_dom	PAX8 PAX2 PAX5	2.61e-06	9	60	3	IPR001523
Domain	PAIRED_2	PAX8 PAX2 PAX5	2.61e-06	9	60	3	PS51057
Domain	PAX	PAX8 PAX2 PAX5	2.61e-06	9	60	3	PF00292
Domain	PAIRED_1	PAX8 PAX2 PAX5	2.61e-06	9	60	3	PS00034
Domain	Fumarylacetoacetase_C-rel	FAHD2B FAHD2A	6.06e-05	4	60	2	IPR011234
Domain	FAA_hydrolase	FAHD2B FAHD2A	6.06e-05	4	60	2	PF01557
Domain	-	FAHD2B FAHD2A	6.06e-05	4	60	2	3.90.850.10
Domain	Homeodomain-like	PAX8 PAX2 PAX5 PBX1 HOXB13	4.23e-03	332	60	5	IPR009057
Pathway	WP_ID_SIGNALING	PAX8 PAX2 PAX5	1.54e-05	16	44	3	M39359
Pubmed	PAX immunoreactivity in poorly differentiated small round cell tumors of childhood.	PAX8 PAX2 PAX5	5.13e-09	3	61	3	24897005
Pubmed	Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development.	PAX8 PAX2 PAX5	5.13e-09	3	61	3	1283313
Pubmed	Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding.	PAX8 PAX2 PAX5	2.05e-08	4	61	3	11134340
Pubmed	Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene.	PAX8 PAX2 PAX5	2.05e-08	4	61	3	8625814
Pubmed	Roles of Pax-genes in developing and adult brain as suggested by expression patterns.	PAX8 PAX2 PAX5	1.02e-07	6	61	3	8126546
Pubmed	Mapping of the human homologs of the murine paired-box-containing genes.	PAX8 PAX2 PAX5	1.02e-07	6	61	3	8431641
Pubmed	Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8.	PAX8 PAX2 PAX5	2.86e-07	8	61	3	11704761
Pubmed	Pax genes in development.	PAX8 PAX2 PAX5	4.28e-07	9	61	3	7883790
Pubmed	Pax genes and their role in organogenesis.	PAX8 PAX2 PAX5	4.28e-07	9	61	3	10197584
Pubmed	Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9.	PAX8 PAX2 PAX5	4.28e-07	9	61	3	7981748
Pubmed	Pax3 Hypomorphs Reveal Hidden Pax7 Functional Genetic Compensation in Utero.	PAX8 PAX2 PAX5	8.39e-07	11	61	3	35645295
Pubmed	Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord.	PAX8 PAX2 PAX5	1.45e-06	13	61	3	17166926
Pubmed	Pax: a murine multigene family of paired box-containing genes.	PAX8 PAX2 PAX5	2.30e-06	15	61	3	1685142
Pubmed	Diffuse expression of PAX2 and PAX8 in the cystic epithelium of mixed epithelial stromal tumor, angiomyolipoma with epithelial cysts, and primary renal synovial sarcoma: evidence supporting renal tubular differentiation.	PAX8 PAX2	3.03e-06	2	61	2	21836481
Pubmed	Flat pattern of nephrogenic adenoma: previously unrecognized pattern unveiled using PAX2 and PAX8 immunohistochemistry.	PAX8 PAX2	3.03e-06	2	61	2	23328975
Pubmed	Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones.	FAHD2B FAHD2A	3.03e-06	2	61	2	15774318
Pubmed	PAX2, PAX8, and PR are correlated with ovarian seromucinous borderline tumor with endometriosis.	PAX8 PAX2	3.03e-06	2	61	2	35387670
Pubmed	Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties.	PAX8 PAX2	3.03e-06	2	61	2	8413205
Pubmed	PAX2 and PAX8 expression in primary and metastatic renal tumors: a comprehensive comparison.	PAX8 PAX2	3.03e-06	2	61	2	23194047
Pubmed	Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease.	PAX8 PAX2	3.03e-06	2	61	2	37977366
Pubmed	Utility of PAX8 and PAX2 immunohistochemistry in the identification of renal cell carcinoma in diagnostic cytology.	PAX8 PAX2	3.03e-06	2	61	2	22807381
Pubmed	Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary.	PAX2 PAX5	3.03e-06	2	61	2	10662641
Pubmed	PAX2 and PAX8 expression in primary and metastatic müllerian epithelial tumors: a comprehensive comparison.	PAX8 PAX2	3.03e-06	2	61	2	21989345
Pubmed	Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland.	PAX8 PAX2	3.03e-06	2	61	2	1723950
Pubmed	A subset of solitary fibrous tumors express nuclear PAX8 and PAX2: a potential diagnostic pitfall.	PAX8 PAX2	3.03e-06	2	61	2	26404914
Pubmed	PAX2 and PAX8: useful markers for metastatic effusions.	PAX8 PAX2	3.03e-06	2	61	2	24334997
Pubmed	The utility of PAX8 in comparison with PAX5 immunohistochemical staining in the diagnosis of Hodgkin lymphoma.	PAX8 PAX5	3.03e-06	2	61	2	35926290
Pubmed	PAX8 and PAX2 immunostaining facilitates the diagnosis of primary epithelial neoplasms of the male genital tract.	PAX8 PAX2	3.03e-06	2	61	2	21934480
Pubmed	Identification of two promoters for human D-amino acid oxidase gene: implication for the differential promoter regulation mediated by PAX5/PAX2.	PAX2 PAX5	3.03e-06	2	61	2	25500505
Pubmed	Paired box genes, PAX-2 and PAX-8, are not frequently mutated in Wilms tumor.	PAX8 PAX2	3.03e-06	2	61	2	16814811
Pubmed	PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors.	PAX8 PAX2	3.03e-06	2	61	2	1337742
Pubmed	PAX8 and PAX5 are differentially expressed in B-cell and T-cell lymphomas.	PAX8 PAX5	3.03e-06	2	61	2	23163626
Pubmed	Diagnostic utility of PAX2 and PAX5 in distinguishing non-small cell lung cancer from small cell lung cancer.	PAX2 PAX5	3.03e-06	2	61	2	26823795
Pubmed	PAX8 and PAX2 expression in endocervical adenocarcinoma in situ and high-grade squamous dysplasia.	PAX8 PAX2	3.03e-06	2	61	2	23202787
Pubmed	PAX2 and PAX8 reliably distinguishes ovarian serous tumors from mucinous tumors.	PAX8 PAX2	3.03e-06	2	61	2	24992169
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIVEP2 CELSR3 LRRC24 MTG2 NAGLU PAX2 HERC1 MED13L MBD6 SIPA1L2 HOXB13	3.09e-06	1105	61	11	35748872
Pubmed	A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum.	PAX8 PAX2 PAX5	4.88e-06	19	61	3	8575294
Pubmed	Prorenin receptor is critical for nephron progenitors.	FGF20 PAX8 PAX2	5.73e-06	20	61	3	26658320
Pubmed	Sall1 balances self-renewal and differentiation of renal progenitor cells.	FGF20 PAX8 NCAM2 PAX2	6.04e-06	67	61	4	24550112
Pubmed	Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain.	PAX8 PAX2 PAX5	6.68e-06	21	61	3	11500373
Pubmed	Evaluation of putative renal cell carcinoma markers PAX-2, PAX-8, and hKIM-1 in germ cell tumors: a tissue microarray study of 100 cases.	PAX8 PAX2	9.07e-06	3	61	2	22495365
Pubmed	A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle.	FAHD2B FAHD2A	9.07e-06	3	61	2	38287013
Pubmed	Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.	PAX8 PAX5	9.07e-06	3	61	2	1516825
Pubmed	Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage.	PAX8 PAX2	9.07e-06	3	61	2	17047028
Pubmed	Pax2 and Pax8 Proteins Regulate Urea Transporters and Aquaporins to Control Urine Concentration in the Adult Kidney.	PAX8 PAX2	9.07e-06	3	61	2	32381599
Pubmed	Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors.	PAX8 PAX2	9.07e-06	3	61	2	7856737
Pubmed	Diagnostic Utility of Pax8, Pax2, and NGFR Immunohistochemical Expression in Pediatric Renal Tumors.	PAX8 PAX2	9.07e-06	3	61	2	28426529
Pubmed	Pax2.1 is required for the development of thyroid follicles in zebrafish.	PAX8 PAX2	9.07e-06	3	61	2	12117823
Pubmed	PAX2(-)/PAX8(-)/inhibin A(+) immunoprofile in hemangioblastoma: A helpful combination in the differential diagnosis with metastatic clear cell renal cell carcinoma to the central nervous system.	PAX8 PAX2	9.07e-06	3	61	2	21263247
Pubmed	PAX2, PAX8 and CDX2 Expression in Metastatic Mucinous, Primary Ovarian Mucinous and Seromucinous Tumors and Review of the Literature.	PAX8 PAX2	9.07e-06	3	61	2	26797858
Pubmed	Characterization of a novel Lbx1 mouse loss of function strain.	PAX8 PAX2 PAX5	1.30e-05	26	61	3	34906895
Pubmed	Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.	PAX8 PAX2 PAX5	1.30e-05	26	61	3	21303848
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	SYNE1 PGLYRP2 MTCL1	1.46e-05	27	61	3	18649358
Pubmed	Value of PAX8, PAX2, claudin-4, and h-caldesmon immunostaining in distinguishing peritoneal epithelioid mesotheliomas from serous carcinomas.	PAX8 PAX2	1.81e-05	4	61	2	23196794
Pubmed	Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development.	PAX2 PAX5	1.81e-05	4	61	2	10934015
Pubmed	Pax2/Pax8-defined subdomains and the occurrence of apoptosis in the posterior placodal area of mice.	PAX8 PAX2	1.81e-05	4	61	2	28160066
Pubmed	Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1.	PAX2 PAX5	3.02e-05	5	61	2	7577673
Pubmed	Value of PAX8, PAX2, napsin A, carbonic anhydrase IX, and claudin-4 immunostaining in distinguishing pleural epithelioid mesothelioma from metastatic renal cell carcinoma.	PAX8 PAX2	3.02e-05	5	61	2	23503645
Pubmed	The oncogenic potential of Pax genes.	PAX8 PAX2	3.02e-05	5	61	2	8099544
Pubmed	Molecular genetics of the Pax gene family.	PAX8 PAX2	4.52e-05	6	61	2	1485966
Pubmed	Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors.	PAX2 PAX5	4.52e-05	6	61	2	22308434
Pubmed	Development of a screening set for new (CAG/CTG)n dynamic mutations.	NPR1 MN1	4.52e-05	6	61	2	8786123
Pubmed	Pbx1 is essential for adrenal development and urogenital differentiation.	PAX2 PBX1	4.52e-05	6	61	2	14595835
Pubmed	Immunohistochemical distinction of renal cell carcinoma from other carcinomas with clear-cell histomorphology: utility of CD10 and CA-125 in addition to PAX-2, PAX-8, RCCma, and adipophilin.	PAX8 PAX2	4.52e-05	6	61	2	25279712
Pubmed	Nephric lineage specification by Pax2 and Pax8.	PAX8 PAX2	4.52e-05	6	61	2	12435636
Pubmed	Pax2 contributes to inner ear patterning and optic nerve trajectory.	PAX2 PAX5	6.32e-05	7	61	2	8951055
Pubmed	FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.	FGF20 PAX2	6.32e-05	7	61	2	22698282
Pubmed	Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations.	PAX2 PAX5	6.32e-05	7	61	2	9405645
Pubmed	Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.	PAX8 PAX2	6.32e-05	7	61	2	7990960
Pubmed	A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.	PAX8 PAX2	6.32e-05	7	61	2	7590254
Pubmed	Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney.	PAX2 PBX1	6.32e-05	7	61	2	12591246
Pubmed	Cooperation of Pax2 and Pax5 in midbrain and cerebellum development.	PAX2 PAX5	6.32e-05	7	61	2	9159136
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	JCAD HIVEP2 CELSR3 PPT1 KLHL7 SYNE1 NCAM2 MED13L PBX1 CEP63	7.43e-05	1285	61	10	35914814
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PRRC2C SYNE1 MTCL1 MED13L SIPA1L2 SLC12A5	7.98e-05	407	61	6	12693553
Pubmed	Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia.	PAX8 PAX2	8.42e-05	8	61	2	10471511
Pubmed	AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.	PBX1 HOXB13	8.42e-05	8	61	2	9343407
Pubmed	Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.	PAX2 PAX5	8.42e-05	8	61	2	22474389
Pubmed	Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons.	COL4A6 DDR1	8.42e-05	8	61	2	10970885
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	FCSK TTF2 PRRC2C MTG2 PSMD13 TRMT61B SIPA1L2	9.10e-05	606	61	7	36538041
Pubmed	Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.	NCAM2 PAX2	1.08e-04	9	61	2	15520281
Pubmed	Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.	PAX8 PAX2	1.08e-04	9	61	2	29377931
Pubmed	Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region.	PAX2 PAX5	1.08e-04	9	61	2	15872005
Pubmed	The role of Six1 in mammalian auditory system development.	PAX8 PAX2	1.08e-04	9	61	2	12874121
Pubmed	FGF8 initiates inner ear induction in chick and mouse.	PAX8 PAX2	1.08e-04	9	61	2	15741321
Pubmed	Characterization of lipid-linked oligosaccharide accumulation in mouse models of Batten disease.	PPT1 NAGLU	1.08e-04	9	61	2	15647513
Pubmed	Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation.	PAX8 PAX2	1.08e-04	9	61	2	20727173
Pubmed	Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells.	PAX2 PAX5	1.08e-04	9	61	2	18522499
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	JCAD TTF2 MTCL1 TIPRL PATJ SIPA1L2	1.32e-04	446	61	6	24255178
Pubmed	The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes.	PAX2 PAX5	1.35e-04	10	61	2	15872002
Pubmed	Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner.	TTF2 PAX8	1.65e-04	11	61	2	22167068
Pubmed	The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease.	PAX2 PAX5	1.65e-04	11	61	2	16243425
Pubmed	Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear.	PAX8 PAX2	1.65e-04	11	61	2	16916509
Pubmed	Pax2/5 and Pax6 subdivide the early neural tube into three domains.	PAX2 PAX5	1.65e-04	11	61	2	10354469
Pubmed	A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis.	PAX8 PAX2	1.65e-04	11	61	2	23920117
Pubmed	Homeobox genes: a link between development, cell cycle, and cancer?	PAX2 PAX5	1.65e-04	11	61	2	10328847
Pubmed	Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects.	PAX8 PAX2	1.65e-04	11	61	2	17300925
Pubmed	β-Catenin in the kidney stroma modulates pathways and genes to regulate kidney development.	PAX2 PBX1	1.65e-04	11	61	2	37227110
Pubmed	Fgf3 and Fgf10 are required for mouse otic placode induction.	PAX8 PAX2	1.65e-04	11	61	2	12810586
Pubmed	Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer.	PAX2 PAX5	1.97e-04	12	61	2	16530751
Pubmed	Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets.	ADRM1 PSMD13	1.97e-04	12	61	2	16501559
GeneFamily	Paired boxes	PAX8 PAX2 PAX5	7.13e-07	9	38	3	675
GeneFamily	PRD class homeoboxes and pseudogenes	PAX8 PAX2 PAX5	9.45e-04	92	38	3	521
Coexpression	GSE22229_RENAL_TRANSPLANT_VS_HEALTHY_PBMC_DN	MFSD6 FAHD2A PRXL2A NCAM2 PGLYRP2 MBD6	6.77e-06	198	61	6	M7480
Coexpression	GSE21670_UNTREATED_VS_TGFB_TREATED_STAT3_KO_CD4_TCELL_UP	DDR1 SERPINB6 NCAM2 PBX1 PATJ HSPA1L	6.97e-06	199	61	6	M7474
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	JCAD SYNE1 CDRT15L2 PBX1 MN1	5.21e-06	183	61	5	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TTF2 HIVEP2 PRRC2C PATJ ITK	5.35e-06	184	61	5	bd786db4dc4edae6d5cfc0b69901983dea19f729
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 PAX8 DMKN MRC2 SYNE1	5.79e-06	187	61	5	9225caf66e06ebe57e90d677122acb6498607f36
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 PAX8 DMKN MRC2 SYNE1	6.26e-06	190	61	5	b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 PAX8 DMKN MRC2 SYNE1	6.26e-06	190	61	5	a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 PAX8 DMKN MRC2 SYNE1	6.75e-06	193	61	5	0f2167eef8203a5659c8c72e4e77646003d64797
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PRRC2C SYNE1 ZNF620 MN1 ITK	7.28e-06	196	61	5	ea8eceacc5d5e1a22b77c31e7c45985dc7bb15de
ToppCell	COVID-19-lung-Capillary_Aerocytes\|COVID-19 / Disease (COVID-19 only), tissue and cell type	JCAD SERPINB6 SYNE1 XKR6 SIPA1L2	7.28e-06	196	61	5	49cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCell	COVID-19-lung-Capillary_Aerocytes\|lung / Disease (COVID-19 only), tissue and cell type	JCAD SERPINB6 SYNE1 XKR6 SIPA1L2	7.28e-06	196	61	5	4ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell	severe_COVID-19-B_cell\|World / disease group, cell group and cell class (v2)	DDR1 MRC2 PAX5 MN1	4.44e-05	143	61	4	28b0e168126a9fe60541dc12bfab385b7a0a2342
ToppCell	severe_COVID-19-B_cell\|severe_COVID-19 / disease group, cell group and cell class (v2)	DDR1 MRC2 PAX5 MN1	4.56e-05	144	61	4	c7f696e55e2d959c58ec32640c71ef86ee25203c
ToppCell	COVID-19-kidney-Mito-rich_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	JCAD SYNE1 CDRT15L2 PBX1	4.68e-05	145	61	4	afed661aef990edb8e7012ab67ace56443520c9f
ToppCell	mild_COVID-19_(asymptomatic)-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	CATSPERD MRC2 PATJ SLC12A5	5.63e-05	152	61	4	f944743f40ff6ed3a7a096dd53e12d3526c67c4d
ToppCell	mild_COVID-19_(asymptomatic)-CD8+_T_naive\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	CATSPERD MRC2 PATJ SLC12A5	6.07e-05	155	61	4	e2c901d5c9e42d25d7702e5e8fc19b06f7c817be
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD WDR87 SYNE1 PBX1	6.70e-05	159	61	4	d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAX8 PGLYRP2 PATJ ITK	7.20e-05	162	61	4	b877b232f0a879a9058d81ad4730e7846484b7c3
ToppCell	facs-Lung-EPCAM-3m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAX8 PGLYRP2 PATJ ITK	7.20e-05	162	61	4	7384a4dd38ed68ca02a72df6deff4d34c9694ce1
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TTF2 PGLYRP2 TRMT61B ITK	7.73e-05	165	61	4	ec16a4979b3f203c9f66ed387a7a17bf3a1d3f86
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	JCAD HIVEP2 PBX1 PATJ	8.48e-05	169	61	4	e9c0e0f4c421c7bdbf1a7e33002f3cf22ea307cb
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	JCAD HIVEP2 PBX1 PATJ	8.48e-05	169	61	4	d375a1df1ecc938f66bad92e54b8cda26ca9c472
ToppCell	BAL-Control-Lymphocyte-T/NK-NK_cell-NK\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	JCAD HIVEP2 PBX1 PATJ	8.48e-05	169	61	4	58f805c0be507bd5fadc9ea3555032daabbc8ab8
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	PRRC2C SYNE1 HERC1 ITK	8.88e-05	171	61	4	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CATSPERD PAX5 FER1L6 ITK	8.88e-05	171	61	4	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	droplet-Liver-nan-3m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A6 CATSPERD MTCL1 CD163	9.08e-05	172	61	4	1f335ccb92b22d0412954e8fc3af212f96410b67
ToppCell	droplet-Marrow-BM_(NON-STC)\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMKN SYNE1 PRXL2A HERC1	9.08e-05	172	61	4	6004327045f03d832fdabe6cb2f8b1b1db57789a
ToppCell	droplet-Marrow-BM_(NON-STC)-30m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMKN SYNE1 PRXL2A HERC1	9.08e-05	172	61	4	31c5710fd7ebb221e703545595f5ec0ee3a32bcf
ToppCell	droplet-Liver-nan-3m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL4A6 CATSPERD MTCL1 CD163	9.08e-05	172	61	4	bb96c896d125e10b71e94e2bdad243899045af5c
ToppCell	15-Trachea-Mesenchymal-Mesenchyme_RSPO2+\|Trachea / Age, Tissue, Lineage and Cell class	COL4A6 SP6 MTCL1 SIPA1L2	9.50e-05	174	61	4	fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NPR1 SYNE1 PBX1 MN1	9.92e-05	176	61	4	dc5a22f9d1347f157bdd93e6e5769b983deccf1a
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ADRM1 GPR157 MTG2 HOXB13	1.08e-04	180	61	4	c3d1521ac90f2e3fc31158e6e61907e05c37af39
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-MEP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	SERPINB6 CATSPERD PRXL2A PBX1	1.11e-04	181	61	4	ee207ea171e2ffc22a7f850be57bb118a87e0f81
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A6 PAX8 PAX2 PATJ	1.11e-04	181	61	4	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A6 PAX8 PAX2 PATJ	1.13e-04	182	61	4	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD PBX1 SIPA1L2 MN1	1.18e-04	184	61	4	688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A6 NPR1 SYNE1 SIPA1L2	1.20e-04	185	61	4	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A6 NPR1 SYNE1 SIPA1L2	1.20e-04	185	61	4	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	COL4A6 PRRC2C SCN10A MED13L	1.23e-04	186	61	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	Control-Lymphoid-Tregs\|Control / Condition, Lineage and Cell class	SYNE1 PGLYRP2 PATJ ITK	1.23e-04	186	61	4	6144f32a370594e45b91da142b4f435370c69b9a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PAX8 SYNE1 PAX2 PATJ	1.23e-04	186	61	4	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	JCAD SERPINB6 SP6 XKR6	1.25e-04	187	61	4	97b2463fb37e7196dd2f92553acf8e7bc3ec40dd
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF112 RASGEF1A PATJ SLC12A5	1.25e-04	187	61	4	1b2fdbfb1ce3f19795dfc4b1da5a94f4b057ec41
ToppCell	Control-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	SERPINB6 SYNE1 XKR6 SIPA1L2	1.28e-04	188	61	4	88b3415e33db81726dd29c1f50c886e057af50a0
ToppCell	COPD-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	SERPINB6 SYNE1 XKR6 MED13L	1.28e-04	188	61	4	1aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCell	COVID-19-kidney-CD-PC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	COL4A6 PAX8 PAX2 PATJ	1.28e-04	188	61	4	8f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF112 MTCL1 PATJ SLC12A5	1.31e-04	189	61	4	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	JCAD SERPINB6 XKR6 SIPA1L2	1.36e-04	191	61	4	1de0bdfd13bd930691564c2673f2e66393bc0255
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	JCAD NPR1 PBX1 MN1	1.39e-04	192	61	4	27ff3621e177e7932dd44dd6baa81551ea75a874
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 RNF112 RASGEF1A SLC12A5	1.41e-04	193	61	4	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 RNF112 RASGEF1A SLC12A5	1.41e-04	193	61	4	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 RNF112 RASGEF1A SLC12A5	1.41e-04	193	61	4	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF112 MTCL1 PATJ SLC12A5	1.41e-04	193	61	4	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	droplet-Kidney-nan-21m-Endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPR1 PBX1 MN1 SLC12A5	1.41e-04	193	61	4	0e39b6c8e7382e61a9891f6c7e3df2a859788219
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Sncg_(Neuron.Gad1Gad2.Synpr-Sncg)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PAX2 FER1L6 ITK	1.44e-04	74	61	3	216721986c3055f2d9b4702be9693b3a0892283c
ToppCell	Posterior_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Sncg_(Neuron.Gad1Gad2.Synpr-Sncg)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	PAX2 FER1L6 ITK	1.44e-04	74	61	3	a7f7ed7316c226e18ee62d0149be7404326817c6
ToppCell	IPF-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	SERPINB6 SYNE1 XKR6 SIPA1L2	1.44e-04	194	61	4	777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCell	COVID-19-kidney-Glomerular_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	JCAD NPR1 SYNE1 PBX1	1.44e-04	194	61	4	660535b492445063d965095a50e1e299ce04c50a
ToppCell	Control-Multiplet\|Control / Disease state, Lineage and Cell class	DMKN SYNE1 PBX1 PATJ	1.47e-04	195	61	4	618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCell	Control-Multiplet-Multiplet\|Control / Disease state, Lineage and Cell class	DMKN SYNE1 PBX1 PATJ	1.47e-04	195	61	4	06ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD NPR1 SYNE1 PBX1	1.50e-04	196	61	4	d323f7dc41380446e5967c69832bea88351a9331
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD NPR1 SYNE1 PBX1	1.50e-04	196	61	4	65d882c6e7f6d5778b8a5fd4fdaf012e1b9f6100
ToppCell	proximal-Endothelial-Capillary-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	JCAD NPR1 SP6 MN1	1.53e-04	197	61	4	ddb8ea895f0f34d4f20a0740b708fa0f3e378801
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MRC2 SYNE1 NCAM2 MN1	1.53e-04	197	61	4	0dd71e399f253787fa546a7e90c5373180b89ffd
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PRRC2C SYNE1 HERC1 ITK	1.53e-04	197	61	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	proximal-Endothelial-Capillary\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	JCAD NPR1 SP6 MN1	1.53e-04	197	61	4	53baef54bd85c60ae24a3c163b3a3d937fb6ff0b
ToppCell	proximal-3-Endothelial-Capillary\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	JCAD NPR1 SP6 MN1	1.53e-04	197	61	4	a1a61c03d67272693ec23e0d15f0a12bf618e2da
ToppCell	COVID_vent-Lymphocytic-T_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	HIVEP2 SYNE1 PATJ ITK	1.53e-04	197	61	4	ad702e440a74d54cfdcb8bb1c66bd8e0e71ab04e
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIVEP2 SYNE1 XKR6 SLC12A5	1.56e-04	198	61	4	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HIVEP2 SYNE1 XKR6 SLC12A5	1.56e-04	198	61	4	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PRRC2C SYNE1 HERC1 ITK	1.59e-04	199	61	4	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	LPS_IL1RA\|World / Treatment groups by lineage, cell group, cell type	HIVEP2 PRRC2C MED13L SIPA1L2	1.62e-04	200	61	4	a02fa5b3c4723a6eaa3c685588666c710478dd25
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control_saline / Treatment groups by lineage, cell group, cell type	JCAD NPR1 SERPINB6 SIPA1L2	1.62e-04	200	61	4	041a34080120c9f613373c20dcc366292f558040
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid-Megakaryocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PCF11 PRRC2C PBX1 MBD6	1.62e-04	200	61	4	0d76b006d8e8b32174e65e400acd0674354b962c
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_basal-Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	COL4A6 DDR1 DMKN PRXL2A	1.62e-04	200	61	4	9da214f756a03516eaafde00289b90f69623b9f3
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PCF11 PRRC2C PBX1 MBD6	1.62e-04	200	61	4	cc8368665bc6bb7c4f39632ccff07ceaa98a7b65
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DDR1 PAX8 DMKN PAX2	1.62e-04	200	61	4	8954553c05849f3cd591ec663d9caeff2035e168
Disease	Bilateral renal hypoplasia	PAX2 PBX1	3.93e-06	2	59	2	C0431692
Disease	FEV/FEC ratio	JCAD HIVEP2 KLHL7 GPR157 MRC2 PRXL2A PAX2 MTCL1 HERC1 TRMT61B MN1	2.76e-05	1228	59	11	EFO_0004713
Disease	heart rate response to exercise	SCN10A PAX2 XKR6	8.85e-05	43	59	3	EFO_0009184
Disease	Intellectual Disability	FCSK HIVEP2 SYNE1 NAGLU MED13L MN1	2.67e-04	447	59	6	C3714756
Disease	Feeding difficulties	FCSK MN1	5.89e-04	18	59	2	C0232466
Disease	Precursor B-cell lymphoblastic leukemia	PAX5 PBX1	8.05e-04	21	59	2	C1292769
Disease	autism spectrum disorder symptom	CTU2 PATJ	9.68e-04	23	59	2	EFO_0005426
Disease	bone density	TTF2 MTCL1 PSMD13 MED13L PATJ	1.07e-03	388	59	5	EFO_0003923
Disease	maximal oxygen uptake measurement	SCN10A PAX2	1.24e-03	26	59	2	EFO_0004887
Disease	energy expenditure	MTCL1 PATJ	1.34e-03	27	59	2	EFO_0005109
Disease	Drug habituation	SYNE1 PBX1 PATJ	1.60e-03	115	59	3	C0013170
Disease	Substance-Related Disorders	SYNE1 PBX1 PATJ	1.60e-03	115	59	3	C0236969
Disease	Drug abuse	SYNE1 PBX1 PATJ	1.60e-03	115	59	3	C0013146
Disease	Drug Use Disorders	SYNE1 PBX1 PATJ	1.60e-03	115	59	3	C0013222
Disease	Drug Dependence	SYNE1 PBX1 PATJ	1.60e-03	115	59	3	C1510472
Disease	Substance Dependence	SYNE1 PBX1 PATJ	1.60e-03	115	59	3	C0038580
Disease	Substance Use Disorders	SYNE1 PBX1 PATJ	1.60e-03	115	59	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	SYNE1 PBX1 PATJ	1.60e-03	115	59	3	C0029231
Disease	Prescription Drug Abuse	SYNE1 PBX1 PATJ	1.60e-03	115	59	3	C4316881
Disease	Substance abuse problem	SYNE1 PBX1 PATJ	1.64e-03	116	59	3	C0740858
Disease	severe acute respiratory syndrome, COVID-19	CATSPERD NCAM2 PBX1 PATJ SIPA1L2	1.99e-03	447	59	5	EFO_0000694, MONDO_0100096

Protein segments in the cluster

Peptide	Gene	Start	Entry
TGHQIGLRGSLGVDG	FAM234A	246	Q9H0X4
GGDQGIQTGLLYLAG	CDRT15L2	186	A8MXV6
PGEQGLQGLTGHKGF	COL4A6	761	Q14031
LGGRTANQIIFGHNG	CATSPERD	671	Q86XM0
DGHTVGGLQYGGLGQ	DDR1	216	Q08345
GGLQYGGLGQLADGV	DDR1	221	Q08345
FHLDIFGQSLQGGQG	NPR1	271	P16066
GGNHGLFGALEAVNG	NAGLU	411	P54802
IRSGHGGLNQLGGAF	PAX8	6	Q06710
LGELGVQGGHQADGP	MTCL1	1076	Q9Y4B5
GHGGVNQLGGVFVNG	PAX5	16	Q02548
GLSQHLQDGAGGTEG	PBX1	21	P40424
LNHSLFGVLTGGGGQ	MBD6	556	Q96DN6
AGGHIAVGQQGLGSV	MED13L	301	Q71F56
GTRAGQGLQNGHEDG	JCAD	36	Q9P266
ENGQILTHGSGGKGY	HERC1	2046	Q15751
LGHNSRGFGVAIVGN	PGLYRP2	471	Q96PD5
AQAQLEGGLLGLGGH	LRRC24	306	Q50LG9
IFSHGLQGCLEAQGG	MRC2	46	Q9UBG0
GQGERHVLIFDLGGG	HSPA1L	191	P34931
HLGLETGNGGGVINL	FAHD2A	41	Q96GK7
DKIFAVGGQNGLGGL	KLHL7	481	Q8IXQ5
GLAGLLGEGVFNFGE	PSMD13	201	Q9UNM6
QGILQGLHLGLGRGC	MFSD6	571	Q6ZSS7
GHGGVNQLGGVFVNG	PAX2	16	Q02962
GLRFEGQHNQLGGNL	PCF11	966	O94913
LISVGGQHQGVFGLP	PPT1	136	P50897
VHGQSLAGAGGGGFL	FCSK	1016	Q8N0W3
TGTNIGEALGHGLGD	DMKN	31	Q6E0U4
HLGLETGNGGGVINL	FAHD2B	41	Q6P2I3
EGIQNRGHGGGFLTS	CEP63	6	Q96MT8
VVLHGIGNTFQGGAN	GPR157	261	Q5UAW9
LFPLSQEELGGGGHQ	CELSR3	26	Q9NYQ7
EGLLGAGGGRNLVAH	HOXB13	16	Q92826
SILGGAHFGEGNGQI	CD163	526	Q86VB7
FLQQQHVLGAGGGPG	CTU2	181	Q2VPK5
GVSHLIQSGGLGGLQ	SLC12A5	776	Q9H2X9
VQEIGSGQFGLVHLG	ITK	366	Q08881
AQLGHPGDVGQGGLV	MN1	576	Q10571
LGGLEGLGQQVGSHF	FGF20	11	Q9NP95
IGNFGNLIDGGSHHG	FER1L6	506	Q2WGJ9
GQLLSEEGHGAGQEG	SYNE1	2581	Q8NF91
ILYEHQLGQASGLGG	PRRC2C	2521	Q9Y520
KSGGGGDIHQGFQSL	SERPINB6	61	P35237
NGLGQLGFHVNFEGI	SIPA1L2	956	Q9P2F8
GDGGNGGHVILRVDQ	MTG2	106	Q9H4K7
GALQAGLGGYVGDHQ	SP6	146	Q3SY56
SGNLEGEGFILGGVF	PRXL2A	171	Q9BRX8
GGEGGLQSLLGNMSH	ADRM1	151	Q16186
DGGGVGVGFAQLHNL	XKR6	6	Q5GH73
QGLGTNSFLHGLGQE	TRMT61B	16	Q9BVS5
AGGGSGDLIFQDGHL	RASGEF1A	31	Q8N9B8
FNGLGLGAVIGLGVA	NCAM2	696	O15394
AGQGHVGNIFQRLSG	RNF112	326	Q9ULX5
LINDGSGLGFGIVGG	PATJ	251	Q8NI35
ESHRGSLLLGGGAGQ	SCN10A	531	Q9Y5Y9
GDNVLRIQHGSGFGI	TIPRL	51	O75663
VGGLPGNVSQHLDFG	ZNF620	116	Q6ZNG0
TFGVLLNLGLHAGGG	SLC35A4	226	Q96G79
GIGFNIAQVLGQHAG	HIVEP2	1386	P31629
GRGLEGLIFSGHQSG	WDR87	431	Q6ZQQ6
GGVGLNLTGGNHLFL	TTF2	1071	Q9UNY4