Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex, class IB	PIK3R6 PIK3CA	1.43e-04	4	103	2	GO:0005944
Domain	PIEZO	PIEZO1 PIEZO2	3.07e-05	2	104	2	PF15917
Domain	Piezo_RRas-bd_dom	PIEZO1 PIEZO2	3.07e-05	2	104	2	IPR031334
Domain	Piezo	PIEZO1 PIEZO2	3.07e-05	2	104	2	IPR027272
Domain	Piezo_RRas_bdg	PIEZO1 PIEZO2	3.07e-05	2	104	2	PF12166
Domain	Piezo_dom	PIEZO1 PIEZO2	3.07e-05	2	104	2	IPR031805
Domain	FAM26	CALHM3 CALHM4	4.54e-04	6	104	2	IPR029569
Domain	Ca_hom_mod	CALHM3 CALHM4	4.54e-04	6	104	2	PF14798
Domain	ARM-type_fold	ARFGEF2 RIC8B PIK3CA ANKAR USP35 PRKDC TARBP1 ARMC8	6.16e-04	339	104	8	IPR016024
Domain	IPK	ITPKA IP6K2	6.33e-04	7	104	2	PF03770
Domain	IPK	ITPKA IP6K2	6.33e-04	7	104	2	IPR005522
Pubmed	Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle.	CACNA1S RYR1	9.03e-06	2	105	2	12954602
Pubmed	Fluorescence resonance energy transfer (FRET) indicates that association with the type I ryanodine receptor (RyR1) causes reorientation of multiple cytoplasmic domains of the dihydropyridine receptor (DHPR) α(1S) subunit.	CACNA1S RYR1	9.03e-06	2	105	2	23071115
Pubmed	Investigating the genetic susceptibility to exertional heat illness.	CACNA1S RYR1	9.03e-06	2	105	2	32054689
Pubmed	[Feeling the pressure? Identification of two proteins activated by mechanical forces].	PIEZO1 PIEZO2	9.03e-06	2	105	2	21299953
Pubmed	Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development.	PIEZO1 PIEZO2	9.03e-06	2	105	2	38395992
Pubmed	Differential expression of PIEZO1 and PIEZO2 mechanosensitive channels in ocular tissues implicates diverse functional roles.	PIEZO1 PIEZO2	9.03e-06	2	105	2	37820892
Pubmed	Effects of conformational peptide probe DP4 on bidirectional signaling between DHPR and RyR1 calcium channels in voltage-clamped skeletal muscle fibers.	CACNA1S RYR1	9.03e-06	2	105	2	21575570
Pubmed	Multiple regions of RyR1 mediate functional and structural interactions with alpha(1S)-dihydropyridine receptors in skeletal muscle.	CACNA1S RYR1	9.03e-06	2	105	2	12496092
Pubmed	Mechanisms of mechanotransduction and physiological roles of PIEZO channels.	PIEZO1 PIEZO2	9.03e-06	2	105	2	39251883
Pubmed	Immunolocalization of the mechanogated ion channels PIEZO1 and PIEZO2 in human and mouse dental pulp and periodontal ligament.	PIEZO1 PIEZO2	9.03e-06	2	105	2	37975162
Pubmed	Clinical utility gene card for: malignant hyperthermia.	CACNA1S RYR1	9.03e-06	2	105	2	21248738
Pubmed	Exome sequencing reveals novel rare variants in the ryanodine receptor and calcium channel genes in malignant hyperthermia families.	CACNA1S RYR1	9.03e-06	2	105	2	24013571
Pubmed	Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels.	PIEZO1 PIEZO2	9.03e-06	2	105	2	28636944
Pubmed	Comparison of pathogenicity prediction tools on missense variants in RYR1 and CACNA1S associated with malignant hyperthermia.	CACNA1S RYR1	9.03e-06	2	105	2	27147545
Pubmed	Analysis of the entire ryanodine receptor type 1 and alpha 1 subunit of the dihydropyridine receptor (CACNA1S) coding regions for variants associated with malignant hyperthermia in Australian families.	CACNA1S RYR1	9.03e-06	2	105	2	25735680
Pubmed	Piezo channels: from structure to function.	PIEZO1 PIEZO2	9.03e-06	2	105	2	25037583
Pubmed	Functional expression of transgenic 1sDHPR channels in adult mammalian skeletal muscle fibres.	CACNA1S RYR1	9.03e-06	2	105	2	21262876
Pubmed	The alpha(1S) III-IV loop influences 1,4-dihydropyridine receptor gating but is not directly involved in excitation-contraction coupling interactions with the type 1 ryanodine receptor.	CACNA1S RYR1	9.03e-06	2	105	2	18556650
Pubmed	Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?	PIEZO1 PIEZO2	9.03e-06	2	105	2	30324494
Pubmed	Distinct Components of Retrograde Ca(V)1.1-RyR1 Coupling Revealed by a Lethal Mutation in RyR1.	CACNA1S RYR1	9.03e-06	2	105	2	26910427
Pubmed	Increasing the number of diagnostic mutations in malignant hyperthermia.	CACNA1S RYR1	9.03e-06	2	105	2	19191329
Pubmed	Morphology and molecular composition of sarcoplasmic reticulum surface junctions in the absence of DHPR and RyR in mouse skeletal muscle.	CACNA1S RYR1	9.03e-06	2	105	2	12023238
Pubmed	Malignant-hyperthermia susceptibility is associated with a mutation of the alpha 1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle.	CACNA1S RYR1	9.03e-06	2	105	2	9199552
Pubmed	Mechanosensitive channels: in touch with Piezo.	PIEZO1 PIEZO2	9.03e-06	2	105	2	21056836
Pubmed	Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration.	PIEZO1 PIEZO2	9.03e-06	2	105	2	30745454
Pubmed	The role of PIEZO ion channels in the musculoskeletal system.	PIEZO1 PIEZO2	9.03e-06	2	105	2	36717101
Pubmed	Astrocytes in the optic nerve head express putative mechanosensitive channels.	PIEZO1 PIEZO2	9.03e-06	2	105	2	26236150
Pubmed	Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.	PIEZO1 PIEZO2	9.03e-06	2	105	2	27743844
Pubmed	Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause's Corpuscles.	PIEZO1 PIEZO2	9.03e-06	2	105	2	38928429
Pubmed	A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels.	PIEZO1 PIEZO2	9.03e-06	2	105	2	30628892
Pubmed	Piezo1 ion channel pore properties are dictated by C-terminal region.	PIEZO1 PIEZO2	9.03e-06	2	105	2	26008989
Pubmed	Next-generation Sequencing of RYR1 and CACNA1S in Malignant Hyperthermia and Exertional Heat Illness.	CACNA1S RYR1	9.03e-06	2	105	2	25658027
Pubmed	Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.	PIEZO1 PIEZO2	9.03e-06	2	105	2	20813920
Pubmed	Quantitative reduction of RyR1 protein caused by a single-allele frameshift mutation in RYR1 ex36 impairs the strength of adult skeletal muscle fibres.	CACNA1S RYR1	9.03e-06	2	105	2	30689883
Pubmed	Four calcium signaling pathway-related genes were upregulated in microcystic adnexal carcinoma: transcriptome analysis and immunohistochemical validation.	CACNA1S RYR1	9.03e-06	2	105	2	35509066
Pubmed	A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel.	PIEZO1 PIEZO2	9.03e-06	2	105	2	32142647
Pubmed	Functional roles for PIEZO1 and PIEZO2 in urothelial mechanotransduction and lower urinary tract interoception.	PIEZO1 PIEZO2	9.03e-06	2	105	2	34464353
Pubmed	RYR1 and CACNA1S genetic variants identified with statin-associated muscle symptoms.	CACNA1S RYR1	9.03e-06	2	105	2	30325262
Pubmed	Bayesian modeling to predict malignant hyperthermia susceptibility and pathogenicity of RYR1, CACNA1S and STAC3 variants.	CACNA1S RYR1	2.70e-05	3	105	2	31559918
Pubmed	Interaction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling.	CACNA1S RYR1	2.70e-05	3	105	2	16357209
Pubmed	Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures.	CACNA1S RYR1	2.70e-05	3	105	2	11206130
Pubmed	Malignant Hyperthermia Susceptibility	CACNA1S RYR1	2.70e-05	3	105	2	20301325
Pubmed	Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice.	PIEZO1 PIEZO2	2.70e-05	3	105	2	30726728
Pubmed	Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics.	PIEZO1 PIEZO2	2.70e-05	3	105	2	38124148
Pubmed	STAC3 incorporation into skeletal muscle triads occurs independent of the dihydropyridine receptor.	CACNA1S RYR1	2.70e-05	3	105	2	30071129
Pubmed	STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function.	CACNA1S RYR1	2.70e-05	3	105	2	30543836
Pubmed	Myotubularin related protein-2 and its phospholipid substrate PIP2 control Piezo2-mediated mechanotransduction in peripheral sensory neurons.	PIEZO1 PIEZO2	2.70e-05	3	105	2	29521261
Pubmed	Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca2+ channels.	CACNA1S RYR1	2.70e-05	3	105	2	25548159
Pubmed	PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex.	PIEZO1 PIEZO2	2.70e-05	3	105	2	30361375
Pubmed	Piezo1, a mechanically activated ion channel, is required for vascular development in mice.	PIEZO1 PIEZO2	2.70e-05	3	105	2	24958852
Pubmed	Labeling PIEZO2 activity in the peripheral nervous system.	PIEZO1 PIEZO2	2.70e-05	3	105	2	37321223
Pubmed	Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling.	CACNA1S RYR1	2.70e-05	3	105	2	8943043
Pubmed	Alternative splicing alterations of Ca2+ handling genes are associated with Ca2+ signal dysregulation in myotonic dystrophy type 1 (DM1) and type 2 (DM2) myotubes.	CACNA1S RYR1	2.70e-05	3	105	2	23888875
Pubmed	Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth.	PIEZO1 PIEZO2	2.70e-05	3	105	2	35650194
Pubmed	Tumor-intrinsic PIK3CA represses tumor immunogenecity in a model of pancreatic cancer.	PIK3CA PRKDC	5.40e-05	4	105	2	31112530
Pubmed	Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.	PIEZO1 PIEZO2	5.40e-05	4	105	2	27893727
Pubmed	Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.	PIEZO1 PIEZO2	5.40e-05	4	105	2	36574677
Pubmed	Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.	PIEZO1 PIEZO2	5.40e-05	4	105	2	36563677
Pubmed	The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling.	CACNA1S RYR1	5.40e-05	4	105	2	15536090
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	RBM10 DACH1 YTHDC2 OR4K14 NYNRIN HSPA14	7.85e-05	233	105	6	37704626
Pubmed	Identification of LAT4, a novel amino acid transporter with system L activity.	SLC7A2 SLC7A5	8.97e-05	5	105	2	15659399
Pubmed	Piezo1 and Piezo2 foster mechanical gating of K2P channels.	PIEZO1 PIEZO2	8.97e-05	5	105	2	34852225
Pubmed	Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.	PIK3CA PRKDC	8.97e-05	5	105	2	15664519
Pubmed	Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.	PIEZO1 PIEZO2	8.97e-05	5	105	2	36323321
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	CACNA1S RYR1	1.34e-04	6	105	2	10444070
Pubmed	Postsynaptic CaV1.1-driven calcium signaling coordinates presynaptic differentiation at the developing neuromuscular junction.	CACNA1S RYR1	1.34e-04	6	105	2	31804576
Pubmed	Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility.	CACNA1S RYR1	1.34e-04	6	105	2	23818578
Pubmed	Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation.	CACNA1S RYR1	1.88e-04	7	105	2	29130937
Pubmed	Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact.	PIEZO1 PIEZO2	1.88e-04	7	105	2	38733989
Pubmed	Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation.	CACNA1S RYR1	1.88e-04	7	105	2	29949772
Pubmed	Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.	CASP5 CCNH PRKDC CDC6 NLRP8	2.18e-04	179	105	5	19074885
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	POLDIP3 RBM10 DACH1 HAT1 YTHDC2 PRKDC	2.26e-04	283	105	6	30585729
Pubmed	The human olfactory receptor gene family.	OR4K17 OR4K13 OR2B6 OR4K14 OR4L1 OR4X2 OR4K3 OR52A1	2.42e-04	541	105	8	14983052
Pubmed	Piezo1 and Piezo2 collectively regulate jawbone development.	PIEZO1 PIEZO2	2.50e-04	8	105	2	38619396
Pubmed	TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.	PIEZO1 PIEZO2	2.50e-04	8	105	2	34112781
Pubmed	The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.	PIEZO1 PIEZO2	2.50e-04	8	105	2	38228630
Pubmed	Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors.	PIEZO1 PIEZO2	2.50e-04	8	105	2	27161260
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	TCAF1 RBM10 HAT1 YTHDC2 TMEM33 FBXL6 PRKDC STAMBPL1	2.61e-04	547	105	8	37267103
Pubmed	Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy.	CACNA1S RYR1	3.21e-04	9	105	2	23785297
Pubmed	Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.	PRKDC IP6K2	3.21e-04	9	105	2	24657168
Pubmed	Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.	CACNA1S RYR1	3.21e-04	9	105	2	21858002
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	PDXDC1 ENDOD1 ARFGEF2 SLC7A2 PIEZO2 PIK3CA SLC7A5 DEPDC1B	3.40e-04	569	105	8	30639242
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	CACNA1S RYR1	4.00e-04	10	105	2	18434328
Pubmed	SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.	CABLES2 ENDOD1 UNC13D RYR1 WDR19 HHIP EPOP PIGH PIK3CA SNX25	4.59e-04	915	105	10	32393512
Pubmed	Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2.	DNAI2 IP6K2	4.88e-04	11	105	2	30718399
Pubmed	Mutations in C1orf194, encoding a calcium regulator, cause dominant Charcot-Marie-Tooth disease.	CACNA1S RYR1	4.88e-04	11	105	2	31199454
Pubmed	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	GATD3 PROCR ITPKA TNFSF8 DLD IP6K2	6.15e-04	342	105	6	23128233
Pubmed	GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH.	HAT1 PRKDC	9.24e-04	15	105	2	31417184
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	TCAF1 ANKFY1 POLDIP3 HAT1 YTHDC2 TMEM33 FBXO22 STAMBPL1 TARBP1 ARMC8	9.41e-04	1005	105	10	19615732
Pubmed	A vagal reflex evoked by airway closure.	PIEZO1 PIEZO2	1.05e-03	16	105	2	38448588
Pubmed	Differential physiological roles for BIN1 isoforms in skeletal muscle development, function and regeneration.	CACNA1S RYR1	1.05e-03	16	105	2	32994313
Pubmed	Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.	SIGLEC5 PRKDC	1.19e-03	17	105	2	35709757
Pubmed	Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation.	CACNA1S RYR1	1.19e-03	17	105	2	22411552
Pubmed	The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.	HAT1 PRKDC	1.49e-03	19	105	2	20504901
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	TCAF1 ANKFY1 RHOBTB3 TMEM33 CERS5 OXA1L PRKDC	1.77e-03	571	105	7	37167062
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	PDXDC1 CABLES2 PIK3CA SLC7A5 DEPDC1B NOS1AP	1.78e-03	421	105	6	36976175
Pubmed	Nephronophthisis-Related Ciliopathies	NPHP4 WDR19	1.83e-03	21	105	2	27336129
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PIEZO1 ARFGEF2 NPHP4 RYR1 EPOP IL17RE SLC7A5 PRKDC ZC3H7B DNMBP	1.90e-03	1105	105	10	35748872
Pubmed	Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice.	WDR19 HHIP	2.00e-03	22	105	2	25224227
Pubmed	Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation.	PROCR TMEM176A PIGH	2.06e-03	83	105	3	21103663
Cytoband	14q11.2	OR4K17 OR4K13 OR4K14 OR4L1 OXA1L OR4K3	3.90e-06	180	105	6	14q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr14q11	OR4K17 OR4K13 OR4K14 OR4L1 OXA1L OR4K3	1.21e-04	332	105	6	chr14q11
GeneFamily	Olfactory receptors, family 4	OR4K17 OR4K13 OR4K14 OR4L1 OR4X2 OR4K3	7.51e-06	129	66	6	151
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYB5RL HUS1B DENND3 GPIHBP1 SLC29A4	1.80e-06	86	104	5	d20ec61a572b11641647358a546334b217c694f3
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MAB21L4 RHOBTB3 PIEZO1 UNC13D DENND3 LBH	6.94e-06	197	104	6	69d5b8588046d119b5dff9a7fd6f49e97e00a5b7
ToppCell	356C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MAB21L4 RHOBTB3 PIEZO1 UNC13D DENND3 LBH	6.94e-06	197	104	6	e6cbfa267eb2e05b441fd034786faae07bb0e081
ToppCell	Epithelial_cells-AT1-AT2_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	TCAF1 MAB21L4 RHOBTB3 UNC13D DENND3 LBH	7.14e-06	198	104	6	fbc46b20bcd44f2083170aacbc6f5dd00fba685c
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A6 PROCR DACH1 TMEM176A HHIP PIEZO2	7.35e-06	199	104	6	edba1833ef5c4ca122d7c32f97670314e005f93b
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-I_(AT1)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	MAB21L4 PIEZO1 UNC13D DENND3 IL17RE LBH	7.35e-06	199	104	6	5a002d49a8b84c158f7b4d7a3e78e6a937757bb7
ToppCell	droplet-Heart-nan-3m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1S CCNDBP1 SIGLEC5 RYR1 DNMBP	1.95e-05	140	104	5	ab90f6f30d89761687f8836e3d327d143ce49ed4
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	YTHDC2 RYR1 TNFSF8 SLC7A5 CDC6	3.18e-05	155	104	5	b5d5c38b269e9318970fcce564df1c8ed7a7ccc6
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A6 KBTBD8 NUDT2 SIGLEC5 SLC7A2	3.48e-05	158	104	5	6811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL6A6 KBTBD8 NUDT2 SIGLEC5 SLC7A2	3.92e-05	162	104	5	d712bc31840ad1523e3dbf884acbb428a8995001
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_2\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	MAB21L4 RYR1 PIK3R6 TNFSF8 LBH	4.04e-05	163	104	5	f21951e63188eb0c04675a8f81a0da495c26c007
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYB5RL RYR1 EPOP IL17RE NOS1AP	5.22e-05	172	104	5	80b565f6e37f38629f4cf89d5b053b3b8517244e
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A6 PROCR TMEM176A ZNF784 HHIP	5.22e-05	172	104	5	afa36501d48b1456c511fa0d5d326ec05bdc380f
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	UNC13D HHIP PIK3R6 STAMBPL1 CCDC144A	5.98e-05	177	104	5	86c41d262142eeaa95ea7fa6668169eb1bb2953f
ToppCell	Severe-B_intermediate-10\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	CACNA1S RHOBTB3 RYR1 LBH NOS1AP	6.14e-05	178	104	5	b7374a97c51239782bed658381a02cb1b3d9bf66
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MAB21L4 PIEZO1 UNC13D DENND3 IL17RE	7.18e-05	184	104	5	c7073d1b2c4fdb154d87678b92a0629c02116972
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MAB21L4 PIEZO1 UNC13D DENND3 IL17RE	7.18e-05	184	104	5	1ed558a88215b248431c524ea16f13d9022ae98c
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PROCR RHOBTB3 DACH1 TMEM176A HHIP	7.56e-05	186	104	5	360c3e9e5c3a943e68e6939b4a47821bfc75b553
ToppCell	E17.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PROCR DACH1 PIEZO2 GPIHBP1 DNAH8	7.75e-05	187	104	5	e9aa0a5a0f8e2593de63e83b56b53ae33e60af49
ToppCell	E17.5-Endothelial-capillary_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PROCR DACH1 PIEZO2 GPIHBP1 DNAH8	7.75e-05	187	104	5	61b8a53f29bb8b33c69f680b8359a1143a23999d
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D231\|Adult / Lineage, Cell type, age group and donor	RHOBTB3 UNC13D DENND3 IL17RE NOS1AP	8.15e-05	189	104	5	5a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-filiform\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 HHIP EPOP LBH KIF13A	8.35e-05	190	104	5	8a53f4d3c9aca45b5826f53f7dcdfb8bc8280acb
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLB1 CYSLTR1 RYR1 PIK3R6 TNFSF8	8.56e-05	191	104	5	51f5af610983aa73b9f4ece6f27d281ebff89a04
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PLB1 CYSLTR1 RYR1 PIK3R6 TNFSF8	8.56e-05	191	104	5	8fd6bdc9d2b1c8d364221d7bc68d03921b668ab5
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-D\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PROCR TMEM176A SIGLEC5 CCNH C9orf72	8.56e-05	191	104	5	7d00796459f4ff0ab7f06a8379b2d34e76b078b2
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-plasma_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR155 CACNA1S TMEM176A AGA SLC7A5	8.77e-05	192	104	5	6417468829517a0f6e04e7e44eec1622001d4c5c
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ENDOD1 STMN4 HHIP PIEZO2 GPIHBP1	8.77e-05	192	104	5	8dc3016601148243196e925641c9507e9d58c9e0
ToppCell	PCW_07-8.5-Endothelial-Endothelial_immature-endo_immature4_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PROCR SLC22A24 DENND3 GPIHBP1 PIK3R6	8.99e-05	193	104	5	72d20ee257149b238016b44d183ce3fc24b8f621
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-AT1-AT1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MAB21L4 RHOBTB3 UNC13D DENND3 IL17RE	9.67e-05	196	104	5	6731fef8c148b6681d6ed38afdf23c8213e0bbbe
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A6 RHOBTB3 DACH1 TMEM176A HHIP	9.67e-05	196	104	5	85507488f83d8f71b3ee2ad5e5aa0b6ad6193873
ToppCell	cellseq-Epithelial-Epithelial_Alveolar-AT1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	MAB21L4 RHOBTB3 UNC13D DENND3 IL17RE	9.67e-05	196	104	5	6856317cd0cdcb88fe54b4ae905d91e13495b1c4
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAB21L4 RHOBTB3 UNC13D DENND3 IL17RE	9.90e-05	197	104	5	c9c968e223e7814cd8d22975d849a31b7e0af7aa
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-midbrain/hindbrain_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	TMEM176A PARP6 STMN4 LBH PLPPR2	9.90e-05	197	104	5	c7078f6fcf27319ba8c5ebe700bcae7f1e7e39c1
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAB21L4 RHOBTB3 UNC13D DENND3 IL17RE	9.90e-05	197	104	5	734b8db5bb4917c9ce92ed342fe6c22b64b0d3c5
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAB21L4 RHOBTB3 UNC13D DENND3 IL17RE	9.90e-05	197	104	5	e344455e62b3fe94bb242dc0db58d19a1d3878c7
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KBTBD8 TMEM176A HHIP TNFSF8 SLC7A5	9.90e-05	197	104	5	a9f8edeef73a5261d7661dd1987aaa5bf6183af8
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PROCR RHOBTB3 DACH1 TMEM176A HHIP	1.01e-04	198	104	5	09be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Neuronal\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	PARP6 STMN4 BLCAP LBH PLPPR2	1.04e-04	199	104	5	f94307958cead25d38103fcbb35fa45011de1687
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Neuronal-PNs\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	PARP6 STMN4 BLCAP LBH PLPPR2	1.04e-04	199	104	5	c8aaf6ebd1cb6f6e59fdffeb81f9a3c921cc592a
ToppCell	distal-1-Hematologic-EREG+_Dendritic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMEM176A DENND3 TNFSF8 SLC7A5 DEPDC1B	1.04e-04	199	104	5	15249f2f48b1e99d9d062835fd4c705a159e4abb
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PROCR RHOBTB3 DACH1 TMEM176A HHIP	1.04e-04	199	104	5	e78f661b40da34768469549b6e755d330be6bbd8
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	COL6A6 RHOBTB3 TMEM176A PIEZO2 LBH	1.06e-04	200	104	5	c3d4ce70ab51d74c9fe2f5864e52a4a9d7570e10
ToppCell	Lung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL6A6 RHOBTB3 TMEM176A PIEZO2 LBH	1.06e-04	200	104	5	137f8f9d255c66336d4f8b44b2e3f3de721f2bf0
ToppCell	Parenchyma_COVID-19-Stromal-TX-Fibroblasts-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	COL6A6 RHOBTB3 TMEM176A PIEZO2 LBH	1.06e-04	200	104	5	25d3865aa2ced11a5ed40013e83b47d942fdf582
Disease	Malignant hyperthermia, susceptibility to	CACNA1S RYR1	1.16e-05	2	101	2	cv:C5437603
Disease	Malignant hyperthermia	CACNA1S RYR1	1.16e-05	2	101	2	cv:C5779784
Disease	Malignant hyperpyrexia due to anesthesia	CACNA1S RYR1	1.16e-05	2	101	2	C0024591
Disease	malignant hyperthermia (is_implicated_in)	CACNA1S RYR1	3.47e-05	3	101	2	DOID:8545 (is_implicated_in)
Disease	Rare disease with malignant hyperthermia	CACNA1S RYR1	6.93e-05	4	101	2	cv:C5681128
Disease	Renal dysplasia and retinal aplasia	NPHP4 WDR19	2.41e-04	7	101	2	cv:C0403553
Disease	Nephronophthisis, familial juvenile	NPHP4 WDR19	2.41e-04	7	101	2	C1855681
Disease	Senior-Loken syndrome (is_implicated_in)	NPHP4 WDR19	2.41e-04	7	101	2	DOID:0050576 (is_implicated_in)
Disease	Renal dysplasia and retinal aplasia (disorder)	NPHP4 WDR19	7.49e-04	12	101	2	C0403553
Disease	Congenital myopathy (disorder)	CACNA1S RYR1	7.49e-04	12	101	2	C0270960
Disease	smoking status measurement, ulcerative colitis	GATD3 PARP6	8.83e-04	13	101	2	EFO_0000729, EFO_0006527
Disease	Nephronophthisis	NPHP4 WDR19	8.83e-04	13	101	2	C0687120
Disease	neutrophil percentage of granulocytes	PLB1 ITPKA TNFSF8 PRKDC ZC3H7B	1.14e-03	228	101	5	EFO_0007994
Disease	sensorineural hearing loss (implicated_via_orthology)	LNX2 DNAI2	1.91e-03	19	101	2	DOID:10003 (implicated_via_orthology)
Disease	Anophthalmia-microphthalmia syndrome	GATD3 DACH1	2.33e-03	21	101	2	cv:C5680330
Disease	phosphatidylethanolamine measurement	PDXDC1 SIDT2 DEPDC1B SLC29A4	3.00e-03	173	101	4	EFO_0010228

Protein segments in the cluster

Peptide	Gene	Start	Entry
NLLCPFCLKVIKIAT	ZNF280D	446	Q6N043
LAFPLTIRCFLGCEL	PROCR	106	Q9UNN8
PRIIMLTCAFLACKV	CCNH	101	P51946
LIIAAFLARCLRPCF	CALHM3	191	Q86XJ0
PILFELSCIINRCKL	ARFGEF2	1331	Q9Y6D5
KVAVEAFQICCLLLP	DEPDC1B	306	Q8WUY9
IPSLKEGERLFVCIC	DNMBP	61	Q6XZF7
VLKLVGECCPRLTFL	FBXL6	211	Q8N531
CGLIIFRRCLIPKVD	NUDT2	6	P50583
LSLKVCDEALFCLRV	DNAI2	446	Q9GZS0
LCFRPEKVLQILTCI	DENND3	196	A2RUS2
MIPCRAALTFARCLI	SLC7A2	1	P52569
CELICLPQAFDLFLK	DACH1	206	Q9UI36
RLLFERFIAKPCALC	CERS5	61	Q8N5B7
RFIAKPCALCIGIED	CERS5	66	Q8N5B7
CLLCRRQFPSKEALI	RBM10	761	P98175
VCIIIALCRKDPSLL	ANKAR	616	Q7Z5J8
KPVRVCNICFDVLTL	ANKFY1	1151	Q9P2R3
FLPAKALLRVACVCR	FBXO22	36	Q8NEZ5
VVLLCCLATRKLPHF	MAB21L4	326	Q08AI8
HFLCEVPALLKLSCV	OR2B6	176	P58173
LILCCNKFETFPREL	LRRD1	561	A4D1F6
CVLRFNETTLCKPLV	IP6K2	31	Q9UHH9
VLLRCYTCKSLPRDE	GPIHBP1	61	Q8IV16
CPLQRLVLRKCDLTF	NLRP8	896	Q86W28
RLFPALLECFGIVLC	GPR155	41	Q7Z3F1
FSCLPVSRVECMLKL	KIAA1109	4056	Q2LD37
FDRCCKLKDRLPSIV	LBH	51	Q53QV2
CCIAPVLAAKVLRGV	GATD3B	176	A0A0B4J2D5
LTLRCPLKLEAALCQ	IL17RE	291	Q8NFR9
LLDKLLVLCPFSSVC	LNX2	106	Q8N448
LCCLLKAICRVLSIP	ENDOD1	416	O94919
ILVAPCLVLIKCRFQ	OR52A1	156	Q9UKL2
SFFCDLPLVIKLACV	OR4K3	176	Q96R72
SFFCDLPLVIKLACK	OR4K13	176	Q8NH42
DSFFCDLPLVIKLAC	OR4K14	176	Q8NGD5
FCDLPLVTKLACIDI	OR4K17	181	Q8NGC6
NIFCDLPLVIKLACI	OR4L1	176	Q8NH43
CDLVPLLKLACSDTF	OR4X2	171	Q8NGF9
LPVLCCTLQLREEFK	PDXDC1	486	Q6P996
PDKLKGLCIFFVRCR	DNAH8	11	Q96JB1
DLIKELVSCCRRKPF	CYB5RL	271	Q6IPT4
PVDRTLFKCICIRAQ	PHRF1	146	Q9P1Y6
VPEEAAKLVACLCVL	SLC7A5	166	Q01650
ACTVFARCLIFPLIV	OXA1L	146	Q15070
LPRAARLCLSICSVK	PIK3CA	396	P42336
LPLTLLVCCSALQKR	LRIT1	541	Q9P2V4
VCLCCRQPLISKAFE	NPHP4	1321	O75161
LILKRCSEPERYCLA	ITPKA	206	P23677
CLDIVTGRVFKLCKP	KBTBD8	306	Q8NFY9
CLALLCPAFLVGVVR	PLPPR2	241	Q96GM1
LLKPRCSACDEIIFA	PRICKLE1	186	Q96MT3
SPDLKFIEACLRCLR	ARMC8	116	Q8IUR7
RDFVLVKLCQDLPCF	HAT1	286	O14929
VKLCQDLPCFSREKL	HAT1	291	O14929
FLLERKPCTICALVF	BLCAP	36	P62952
NILKLCPREEFLRLC	CASP5	161	P51878
LFCLTLENPLRKACI	CACNA1S	31	Q13698
IIPCLALVRASKACL	CCNDBP1	241	O95273
SPLCLRALAFCALAK	EPOP	36	A6NHQ4
RISPLECKLACLRFF	CALHM4	91	Q5JW98
PRIQDTFCLCEHLLK	CCDC144B	636	Q3MJ40
QRCPLKKESACVRLF	CDC6	136	Q99741
CDVLLVCIGRRPFTK	DLD	306	P09622
LAKVCVLRVRPDSLC	HUS1B	26	Q8NHY5
LVPFLLCQALVRCSS	AGA	11	P20933
CCIAPVLAAKVLRGV	GATD3	176	P0DPI2
PRIQDTFCLCEHLLK	CCDC144A	636	A2RUR9
RRDCLVKLECFRFLP	NOS1AP	421	O75052
NRYLCLAVLPLITKC	RYR1	2551	P21817
RIVLICAKRSLCAAF	CABLES2	176	Q9BTV7
LCLFLTPAERKCSRL	C9orf72	251	Q96LT7
LVFGICSPREECKRI	COL6A6	791	A6NMZ7
IVELFCVCGALKRAR	POLDIP3	296	Q9BY77
CLFCIPRNLIGSELK	NYNRIN	1586	Q9P2P1
LKPAVCTRELCVFSF	PARP6	301	Q2NL67
PLRVIVKDALFCSCL	RHOBTB3	326	O94955
ELLCSPLFNKCIEAI	HSPA14	301	Q0VDF9
LIPRLCCALFKRISL	KIF13A	121	Q9H1H9
GERIKLIPLLCIVCT	SIDT2	741	Q8NBJ9
KLLLTCCSALRPRAT	TMEM176A	31	Q96HP8
LSDRVGRKIICKLCF	SLC22A24	166	Q8N4F4
KLFRGPLVINRCCLD	TCAF1	586	Q9Y4C2
FPVIVESLKCLCNIV	RIC8B	111	Q9NVN3
TCSRVLVFCLLPSKD	SNX25	106	Q9H3E2
PYCTVALDCAIRLKT	PIK3R6	111	Q5UE93
CICLCLIFFLIVKAR	SIGLEC5	451	O15389
TRLFPAVDDKCRILC	WDR19	466	Q8NEZ3
KELPLVSLFCSCFLA	STMN4	11	Q9H169
ILRSLCPCVLKFDDN	PLB1	576	Q6P1J6
LERDLVLPLLCKDYC	HHIP	131	Q96QV1
ALVCLTCVSAILIPR	SLC36A3	376	Q495N2
AVADLLCVCTLPLRV	CYSLTR1	66	Q9Y271
NCSEDLLCILKRAPF	TNFSF8	81	P32971
KRLDLLPLCVTFLLC	SLC26A11	431	Q86WA9
LRCVVLPEDLCHKFL	STAMBPL1	266	Q96FJ0
LPCLKELFAVISCAE	USP35	211	Q9P2H5
KIRSPRFIDFCCLLC	VN1R1	161	Q9GZP7
FRLLLPICLAVACAF	PIEZO2	11	Q9H5I5
RTFDPLLFSCLCVLL	PIEZO2	261	Q9H5I5
KPRLDCLIEVYRSCQ	PIGH	161	Q14442
VCCRAIVKVFLALAA	PRKDC	456	P78527
LKCLDPILTIACTLA	YTHDC2	851	Q9H6S0
SCLRVVFIPLFILCV	SLC29A4	421	Q7RTT9
TTEALKLCFCPLAVL	TTC37	1471	Q6PGP7
LPCVDRILKLCQDIF	PIEZO1	2471	Q92508
VRICAVKFLCLLDGS	TARBP1	1116	Q13395
PCRKAGACLLLTVLD	UNC13D	991	Q70J99
KPACPLFVRRLCLQS	TMEM33	221	P57088
MIPKLLSLLCFRLCV	TARM1	1	B6A8C7
TFLCEICFDSKPRII	ZC3H7B	551	Q9UGR2
CALCPRAFKALAPLL	ZNF784	131	Q8NCA9