Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG-quadruplex DNA binding

DDX11L8 RAD50

1.36e-0414252GO:0051880
MousePhenoembryonic growth arrest

USP7 ATE1 DDX11L8 IPO11 RAD50

7.88e-05346195MP:0001730
DomainMATH

MEP1A USP7

8.68e-0512222SM00061
DomainMATH

MEP1A USP7

8.68e-0512222PF00917
DomainMATH/TRAF_dom

MEP1A USP7

8.68e-0512222IPR002083
DomainMATH

MEP1A USP7

8.68e-0512222PS50144
DomainTRAF-like

MEP1A USP7

3.60e-0424222IPR008974
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

USP7 PUM3 ATE1 IMPDH2 PIGX IPO11 RAD50

1.01e-0675426733060197
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

USP7 STXBP2 IMPDH2 OGDH IPO11

5.10e-0634426530333137
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

PUM3 IMPDH2 CDK13 RPL5 RNF113A IPO11 RAD50

1.23e-05110326734189442
Pubmed

Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.

USP7 IMPDH2 RAD50

3.77e-058726324169447
Pubmed

Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.

USP7 IMPDH2 RPL5 RAD50

3.89e-0525826421081666
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

PUM3 CDK13 RPL5 RNF113A

3.95e-0525926430404004
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

USP7 PUM3 ATE1 OGDH IPO11

4.18e-0553326525544563
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

USP7 PUM3 IMPDH2 OGDH EVI5L IPO11 RAD50

6.76e-05144026730833792
Pubmed

A protein interaction landscape of breast cancer.

USP7 PUM3 IMPDH2 OGDH RPL5

9.49e-0563426534591612
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

USP7 PUM3 IMPDH2 RPL5 RAD50

1.09e-0465326522586326
Pubmed

Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.

USP7 RAD50

1.12e-042126230179224
Pubmed

Intestinal epithelial cells secrete exosome-like vesicles.

MEP1A STXBP2

1.35e-042326211487543
Pubmed

TRAIP regulates replication fork recovery and progression via PCNA.

USP7 RAD50

1.86e-042726227462463
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

USP7 CDK13 IPO11 RAD50

2.09e-0439926437536630
Pubmed

UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.

USP7 CDK13 RAD50

2.09e-0415526334921745
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

PUM3 IMPDH2 OGDH CDK13 RPL5

2.20e-0475926535915203
Pubmed

Nucleolar proteome dynamics.

PUM3 CDK13 RPL5 RAD50

2.52e-0441926415635413
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

USP7 PUM3 CDK13 RPL5

4.31e-0448326436912080
Pubmed

Directed proteomic analysis of the human nucleolus.

PUM3 RPL5 RAD50

4.95e-0420826311790298
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

USP7 MSMO1 CDK13 RNF113A RAD50

5.05e-0491026536736316
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

USP7 PUM3 IMPDH2 OGDH RPL5 RAD50

5.32e-04142526630948266
Pubmed

Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins.

USP7 RPL5

5.45e-044626216791210
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

USP7 IMPDH2 RPL5 RNF113A RAD50

5.68e-0493426533916271
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

USP7 OGDH RAD50

6.97e-0423426336243803
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

USP7 PUM3 IMPDH2 RPL5 RAD50

7.36e-0498926536424410
CytobandEnsembl 112 genes in cytogenetic band chr3p21

IMPDH2 ITIH3

1.38e-02316262chr3p21
ToppCelldroplet-Liver-Hepatocytes-24m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MSMO1 ELOVL2 ITIH3 CYP26A1

1.86e-06154264a5289000597068ee8d559f89bce7bce31f35dd57
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-intestinal_crypt_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PUM3 IMPDH2 IPO11 RAD50

4.28e-0619026452c59001a079c76249abbaa3141e9e661b83d9a0
ToppCelldroplet-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MSMO1 ITIH3 CYP26A1

8.07e-05145263f142b86d4da5b71c189da46cbc4beebdc387ffee
ToppCellSmart-seq2-spleen_(Smart-seq2)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MORC1 CCDC144CP CYP26A1

8.58e-05148263f90ee6fbd71b5e0512af34867202f38409f4de38
ToppCelldroplet-Liver-Hepatocytes-24m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL2 ITIH3 CYP26A1

9.10e-05151263e243b6c76e59035f10519a86399b598dd2123f87
ToppCelldroplet-Liver-Hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL2 ITIH3 CYP26A1

9.10e-05151263cdd2ce0969da446616627e3569bbe5a5d9b475bd
ToppCelldroplet-Liver-Hepatocytes-18m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL2 ITIH3 CYP26A1

1.10e-04161263274838cebdc7af1db32d309dfe42ef7ccd3c190b
ToppCelldroplet-Liver-Hepatocytes-18m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL2 ITIH3 CYP26A1

1.14e-041632631c4de36cf8cdaabb981cda5c7ce7e5ae7b4280e3
ToppCelldroplet-Liver-Hepatocytes-18m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ELOVL2 ITIH3 CYP26A1

1.14e-0416326303d9fa615d9d02ef98e20f28a10aaa6894dd4960
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Proliferative_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RARRES1 MSMO1 RPL5

1.32e-04171263b6b90fcd9e9e379cad8bb0506f7ec7823861e313
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

MORC1 IMPDH2 RPL5

1.69e-04186263aefb9c186254ba7b02a5ae2bcea7bff2574178f7
ToppCell368C-Lymphocytic-NK_cells-NK_cell_D3|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

USP7 RARRES1 PIGX

1.82e-04191263d7920f4a602b50d0ef064eb47001e71939695ed2
ToppCellASK452-Epithelial-Transformed_epithelium|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

RARRES1 MSMO1 RAD50

2.00e-04197263b22a79a5922c865a360e2afc5506a08a512fa76a
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IMPDH2 RPL5 CYP26A1

2.00e-04197263c552d88dca9074e4142372674a426cb61020629f
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IMPDH2 RPL5 CYP26A1

2.00e-041972630b6a0e4a634438e8aa95dd03c409b0e9cbd4dcc8
ToppCellwk_15-18-Mesenchymal-Fibroblast-Early_fibro|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

IMPDH2 MSMO1 RPL5

2.03e-04198263ecf0a8f2e07f336e23b6f32a2c48d3c7eb66572b
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IMPDH2 RPL5 CYP26A1

2.03e-041982634fbf2d56ecf3b116f8ca09dceba8cb93173fd66f
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IMPDH2 RPL5 CYP26A1

2.03e-04198263240e1aa0594ee6de530b2f97d5e392c5fcbf278b
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IMPDH2 RPL5 CYP26A1

2.03e-041982639a229167d4da4abf8c336dfe5cfdf57db756fc8b
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IMPDH2 RPL5 CYP26A1

2.06e-041992638be5ebed3a4053715f69156bbbb159d501a5c197
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-RGCs_early_1|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

IMPDH2 MSMO1 RPL5

2.06e-04199263afed9fefd1355eb3bc17fbc7ce04daad890a0f9f
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IMPDH2 RPL5 CYP26A1

2.06e-04199263a60880d6b73b2f33b33790873b8c1e8096863908
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IMPDH2 RPL5 CYP26A1

2.06e-041992634f79645fb9e229a4a4bf3a1b1bb9760bb4605f96
ToppCellBrain_organoid-organoid_Tanaka_cellReport-2m-Mesenchymal-Unfolded_protein_responsible_cell|2m / Sample Type, Dataset, Time_group, and Cell type.

IMPDH2 MSMO1 RNF113A

2.09e-042002631b08c1be05e2a6a05d8ea35d9a745c4b1809a1b2
Diseaseclonal hematopoiesis mutation measurement

ATE1 STXBP2

1.08e-0355262EFO_0020949
Diseaseomega-3 polyunsaturated fatty acid measurement

OGDH CYP26A1

4.84e-03118262EFO_0010119
Diseasedocosahexaenoic acid measurement

OGDH ELOVL2

5.58e-03127262EFO_0007761
Diseasevery low density lipoprotein particle size measurement

ITIH3 CYP26A1

6.11e-03133262EFO_0008594
DiseaseColonic Neoplasms

MEP1A CYP26A1

7.90e-03152262C0009375
DiseaseMalignant tumor of colon

MEP1A CYP26A1

8.61e-03159262C0007102
Diseasemean arterial pressure

USP7 STXBP2 CYP26A1

9.36e-03499263EFO_0006340

Protein segments in the cluster

PeptideGeneStartEntry
LVLKAYQVKYNPKKM

EVI5L

346

Q96CN4
YQVKYNPKKMKRLEK

EVI5L

351

Q96CN4
KNEMRNIKYKPVDYQ

CCDC148

16

Q8NFR7
EQMYQSKLKKYIAKQ

CCDC144CP

831

Q8IYA2
YFNTMKPKKQYRRKL

CDK13

946

Q14004
QKVKEYQMELKYLKQ

RAD50

201

Q92878
YQMELKYLKQYKEKA

RAD50

206

Q92878
KAKYSRNIVKKFLMY

PUM3

211

Q15397
NTYMVQYEKKIKRKL

MORC1

871

Q86VD1
LFQFIPYMKKYKIQK

MSMO1

71

Q15800
IFQINMIKYIKDKYP

IMPDH2

281

P12268
MNLIKMIVKNYAYKP

IPO11

321

Q9UI26
KIYRGINNYQKYMKP

RNF113A

151

O15541
MYKQIRKQKPVLQKY

OGDH

526

Q02218
NFYVQTYRKKPMKKD

ELOVL2

251

Q9NXB9
YGKRLKAKNLMYLKQ

DDX11L8

431

A8MPP1
KRAIMPYGVYKKQQK

ATE1

476

O95260
KFLQMKRRKYGFIYK

CYP26A1

66

O43174
VYYIKKYQEVLRKMK

TMCO5B

176

A8MYB1
KYEMYLKVQPKQLVK

ITIH3

166

Q06033
LSQFMYYRLKNQKKK

SLC66A1L

86

A1A4F0
YYRLKNQKKKMIFQP

SLC66A1L

91

A1A4F0
YPKRKQQCLQFFYKM

MEP1A

336

Q16819
KNKYNTPKYRMIVRV

RPL5

41

P46777
KKYRELPEQMKQKYI

UBTFL1

136

P0CB47
KMKYKSVYKNVILQV

PIGX

206

Q8TBF5
KKMPQYQKELNKYST

STXBP2

331

Q15833
AQKMKKAYYLTQKIP

TTLL4

976

Q14679
KKKRQQEDYLLYKQM

RARRES1

151

P49788
RQPKKLYYQQLKMKI

USP7

871

Q93009