Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved SA node cell action potential	CACNA1D CACNA1G	2.90e-05	2	108	2	GO:0086059
GeneOntologyMolecularFunction	dynein heavy chain binding	DYNC2I2 DYNC2I1 NISCH	9.90e-05	17	108	3	GO:0045504
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1D CACNA1G	2.87e-04	5	108	2	GO:0086007
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	MAP3K6 MAP3K1 MOS	4.09e-04	27	108	3	GO:0004709
GeneOntologyBiologicalProcess	SA node cell to atrial cardiac muscle cell signaling	CACNA1D RYR2 CACNA1G	1.72e-05	10	110	3	GO:0086018
GeneOntologyBiologicalProcess	SA node cell action potential	CACNA1D RYR2 CACNA1G	1.72e-05	10	110	3	GO:0086015
GeneOntologyBiologicalProcess	SA node cell to atrial cardiac muscle cell communication	CACNA1D RYR2 CACNA1G	2.36e-05	11	110	3	GO:0086070
GeneOntologyBiologicalProcess	regulation of heart rate by cardiac conduction	CACNA1D KCNH6 JUP CACNA1G	6.66e-05	41	110	4	GO:0086091
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	CACNA1D RYR2 KCNH6 JUP CACNA1G	1.03e-04	87	110	5	GO:0086001
HumanPheno	Urethrovaginal fistula	UBR1 DYNC2I2 DYNC2I1	5.86e-06	6	35	3	HP:0008716
HumanPheno	Urethral fistula	UBR1 DYNC2I2 DYNC2I1	1.63e-05	8	35	3	HP:0010480
MousePheno	abnormal atrioventricular node conduction	CACNA1D SHMT2 BCAN RYR2 CACNA1G GNL1	1.02e-05	83	84	6	MP:0006141
Domain	SCAN	PEG3 ZKSCAN8 ZSCAN25 ZNF24 MZF1 ZKSCAN4 ZSCAN23	2.86e-08	56	106	7	SM00431
Domain	SCAN_BOX	PEG3 ZKSCAN8 ZSCAN25 ZNF24 MZF1 ZKSCAN4 ZSCAN23	3.68e-08	58	106	7	PS50804
Domain	SCAN	PEG3 ZKSCAN8 ZSCAN25 ZNF24 MZF1 ZKSCAN4 ZSCAN23	3.68e-08	58	106	7	PF02023
Domain	SCAN_dom	PEG3 ZKSCAN8 ZSCAN25 ZNF24 MZF1 ZKSCAN4 ZSCAN23	3.68e-08	58	106	7	IPR003309
Domain	Retrov_capsid_C	PEG3 ZKSCAN8 ZSCAN25 ZNF24 MZF1 ZKSCAN4 ZSCAN23	4.16e-08	59	106	7	IPR008916
Domain	WD40_repeat_dom	DYNC2I2 GNB1L UBR4 PEX7 DYNC2I1 NOL10 RRP9 MIOS WDFY3	4.91e-05	297	106	9	IPR017986
Domain	WD40	DYNC2I2 GNB1L PEX7 DYNC2I1 NOL10 RRP9 MIOS WDFY3	1.45e-04	268	106	8	SM00320
Domain	Cys-rich_flank_reg_C	LRIT2 LINGO2 CHADL LRRC55 LRRC15	1.60e-04	90	106	5	IPR000483
Domain	LRRCT	LRIT2 LINGO2 CHADL LRRC55 LRRC15	1.60e-04	90	106	5	SM00082
Domain	WD40_repeat	DYNC2I2 GNB1L PEX7 DYNC2I1 NOL10 RRP9 MIOS WDFY3	1.61e-04	272	106	8	IPR001680
Domain	WD_REPEATS_1	DYNC2I2 GNB1L PEX7 DYNC2I1 NOL10 RRP9 MIOS WDFY3	1.86e-04	278	106	8	PS00678
Domain	WD_REPEATS_2	DYNC2I2 GNB1L PEX7 DYNC2I1 NOL10 RRP9 MIOS WDFY3	1.91e-04	279	106	8	PS50082
Domain	WD_REPEATS_REGION	DYNC2I2 GNB1L PEX7 DYNC2I1 NOL10 RRP9 MIOS WDFY3	1.91e-04	279	106	8	PS50294
Domain	LRRNT	LRIT2 LINGO2 CHADL LRRC55 LRRC15	2.39e-04	98	106	5	IPR000372
Domain	LRRNT	LRIT2 LINGO2 CHADL LRRC55 LRRC15	2.39e-04	98	106	5	SM00013
Domain	LRR_1	LRIT2 LINGO2 CHADL LRRC55 RNH1 NISCH LRRC15	2.53e-04	219	106	7	PF00560
Domain	-	LRIT2 NLRP7 LINGO2 CHADL LRRC55 RNH1 NISCH LRRC15	4.89e-04	321	106	8	3.80.10.10
Domain	L_dom-like	LRIT2 NLRP7 LINGO2 CHADL LRRC55 RNH1 NISCH LRRC15	5.64e-04	328	106	8	IPR032675
Domain	-	DYNC2I2 GNB1L PEX7 DYNC2I1 NOL10 RRP9 MIOS WDFY3	6.22e-04	333	106	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	DYNC2I2 GNB1L PEX7 DYNC2I1 NOL10 RRP9 MIOS WDFY3	6.47e-04	335	106	8	IPR015943
Domain	ZF_UBR	UBR1 UBR4	6.58e-04	7	106	2	PS51157
Domain	zf-UBR	UBR1 UBR4	6.58e-04	7	106	2	PF02207
Domain	Znf_UBR	UBR1 UBR4	6.58e-04	7	106	2	IPR003126
Domain	ZnF_UBR1	UBR1 UBR4	6.58e-04	7	106	2	SM00396
Domain	Leu-rich_rpt	LRIT2 LINGO2 CHADL LRRC55 RNH1 NISCH LRRC15	9.00e-04	271	106	7	IPR001611
Domain	LRR	LRIT2 LINGO2 CHADL LRRC55 NISCH LRRC15	1.01e-03	201	106	6	PS51450
Domain	VDCCAlpha1	CACNA1D CACNA1G	1.39e-03	10	106	2	IPR002077
Domain	Quinoprot_gluc/sorb_DH	TRIM56 LRP1	2.03e-03	12	106	2	IPR011041
Domain	Dynein_HC_stalk	DNHD1 DNAH2	2.78e-03	14	106	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH2	2.78e-03	14	106	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH2	2.78e-03	14	106	2	PF08393
Domain	MT	DNHD1 DNAH2	2.78e-03	14	106	2	PF12777
Domain	LRR_8	LRIT2 LINGO2 CHADL LRRC55 LRRC15	2.92e-03	171	106	5	PF13855
Domain	DHC_fam	DNHD1 DNAH2	3.19e-03	15	106	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH2	3.19e-03	15	106	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH2	3.19e-03	15	106	2	PF03028
Domain	Leu-rich_rpt_typical-subtyp	LRIT2 LINGO2 CHADL LRRC55 LRRC15	3.39e-03	177	106	5	IPR003591
Domain	LRR_TYP	LRIT2 LINGO2 CHADL LRRC55 LRRC15	3.39e-03	177	106	5	SM00369
Domain	WD40	DYNC2I2 GNB1L PEX7 DYNC2I1 RRP9 WDFY3	3.61e-03	259	106	6	PF00400
Domain	Ion_trans_dom	CACNA1D RYR2 KCNH6 CACNA1G	4.06e-03	114	106	4	IPR005821
Domain	Ion_trans	CACNA1D RYR2 KCNH6 CACNA1G	4.06e-03	114	106	4	PF00520
Domain	-	CMTR1 COMTD1 METTL26 TRMT44	4.87e-03	120	106	4	3.40.50.150
Domain	SAM-dependent_MTases	CMTR1 COMTD1 METTL26 TRMT44	5.16e-03	122	106	4	IPR029063
Pubmed	Identification of SCAN dimerization domains in four gene families.	ZKSCAN8 ZNF24 ZKSCAN4	1.16e-06	7	113	3	11342224
Pubmed	Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.	RYR2 JUP CACNA1G	5.41e-06	11	113	3	27766308
Pubmed	Pim-3 enhances melanoma cell migration and invasion by promoting STAT3 phosphorylation.	STAT3 PIM3	1.05e-05	2	113	2	29370558
Pubmed	Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism.	SHMT2 STAT3	1.05e-05	2	113	2	31500219
Pubmed	Interleukin-6 induction of protein s is regulated through signal transducer and activator of transcription 3.	STAT3 PROS1	1.05e-05	2	113	2	16840717
Pubmed	Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.	DYNC2I2 DYNC2I1	1.05e-05	2	113	2	30320547
Pubmed	Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes.	CACNA1D RYR2	1.05e-05	2	113	2	33034621
Pubmed	Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity.	CACNA1D CACNA1G	1.05e-05	2	113	2	33144668
Pubmed	A Mouse Model of Glycogen Storage Disease Type IX-Beta: A Role for Phkb in Glycogenolysis.	PHKB PYGL	1.05e-05	2	113	2	36077341
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MYADM TTLL3 HK3 INPP5B PEG3 SHMT2 CEP192 PHKB JUP ZNF24 HPS1 PLD1 TRIM37 PCNT	1.17e-05	1084	113	14	11544199
Pubmed	Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.	DYNC2I2 DYNC2I1 WDFY3	1.81e-05	16	113	3	16096065
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	CACNA1D RYR2 CACNA1G	2.20e-05	17	113	3	27725084
Pubmed	Serine/Threonine kinase 16 phosphorylates STAT3 and confers a JAK2-Inhibition resistance phenotype in triple-negative breast cancer.	STAT3 STK16	3.13e-05	3	113	2	38723720
Pubmed	Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo.	CACNA1D CACNA1G	3.13e-05	3	113	2	24966091
Pubmed	Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.	CACNA1D CACNA1G	3.13e-05	3	113	2	21406960
Pubmed	The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.	PRAG1 STAT3	3.13e-05	3	113	2	26215634
Pubmed	Structure of the dynein-2 complex and its assembly with intraflagellar transport trains.	DYNC2I2 DYNC2I1	3.13e-05	3	113	2	31451806
Pubmed	Inhibition of G protein-gated K+ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia.	CACNA1D CACNA1G	3.13e-05	3	113	2	32555258
Pubmed	Regulation of Stat3 activation by MEK kinase 1.	MAP3K1 STAT3	3.13e-05	3	113	2	11278353
Pubmed	A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.	UBR1 UBR4	6.25e-05	4	113	2	16055722
Pubmed	Interactions of the dynein-2 intermediate chain WDR34 with the light chains are required for ciliary retrograde protein trafficking.	DYNC2I2 DYNC2I1	6.25e-05	4	113	2	30649997
Pubmed	Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation.	UBR1 STAT3	6.25e-05	4	113	2	18614536
Pubmed	The substrate recognition domains of the N-end rule pathway.	UBR1 UBR4	6.25e-05	4	113	2	19008229
Pubmed	Heterodimer formation of the myeloid zinc finger 1 SCAN domain and association with promyelocytic leukemia nuclear bodies.	ZNF24 MZF1	6.25e-05	4	113	2	18472161
Pubmed	ASK1 and MAP2K6 as modifiers of age at onset in Huntington's disease.	PEX7 MAP3K6	6.25e-05	4	113	2	18327563
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	UBR4 C15orf39 CEP192 COMTD1 PRAG1 CLDN23 PIM3 NISCH RIPOR1 WDFY3 MRPL46 SIPA1L2 PCNT	6.38e-05	1105	113	13	35748872
Pubmed	Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.	SHMT2 FTCD PYGL	6.43e-05	24	113	3	17937387
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	GNB1L HTATIP2 HAUS5 STAT3 ZNF24 NISCH MANSC4 GNL1	7.06e-05	419	113	8	33001583
Pubmed	Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.	INPP4A INPP5B	1.04e-04	5	113	2	25869668
Pubmed	Oocyte influences on early development: the regulatory proteins leptin and STAT3 are polarized in mouse and human oocytes and differentially distributed within the cells of the preimplantation stage embryo.	STAT3 MOS	1.04e-04	5	113	2	9464852
Pubmed	Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.	DYNC2I2 DYNC2I1	1.04e-04	5	113	2	25830415
Pubmed	Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components.	CEP192 PCNT	1.04e-04	5	113	2	19543530
Pubmed	Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability.	CACNA1D RYR2	1.04e-04	5	113	2	31461656
Pubmed	Interaction of WDR60 intermediate chain with TCTEX1D2 light chain of the dynein-2 complex is crucial for ciliary protein trafficking.	DYNC2I2 DYNC2I1	1.04e-04	5	113	2	29742051
Pubmed	Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.	CACNA1D RYR2	1.04e-04	5	113	2	31663850
Pubmed	Developmental expression patterns of alpha1H T-type Ca2+ channels during spermatogenesis and organogenesis in mice.	CACNA1D CACNA1G	1.04e-04	5	113	2	12060068
Pubmed	Subunit composition of the human cytoplasmic dynein-2 complex.	DYNC2I2 DYNC2I1	1.56e-04	6	113	2	25205765
Pubmed	USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis.	UBA7 UBE2Z	1.56e-04	6	113	2	20975683
Pubmed	Overexpression of phospholipase D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells.	STAT3 PLD1	1.56e-04	6	113	2	22504301
Pubmed	The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis.	CEP192 PCNT	1.56e-04	6	113	2	18207742
Pubmed	Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.	UBR1 UBE2Z	2.17e-04	7	113	2	21816346
Pubmed	Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway.	MAP3K1 STAT3	2.17e-04	7	113	2	12763138
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1D CACNA1G	2.17e-04	7	113	2	12900400
Pubmed	The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.	UBR1 UBR4	2.17e-04	7	113	2	34893540
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	RPS5 UBR4 HAUS5 CEP192 PHKB FRY MRPL46 SIPA1L2 TRIM37	2.47e-04	639	113	9	23443559
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1D RYR2 CACNA1G	2.59e-04	38	113	3	30786075
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	UBR4 PEG3 DYNC2I1 FTCD METTL26 STAT3 FRY UBA7 NISCH LRP1 WDFY3 TRIM37 PCNT	2.82e-04	1285	113	13	35914814
Pubmed	Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.	UBR1 INPP5B UBR4 HAUS5 SHMT2 MRPL28 RNH1 MRPL46	2.88e-04	515	113	8	31617661
Pubmed	The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4.	PEG3 MZF1	2.89e-04	8	113	2	9149948
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1D CACNA1G	2.89e-04	8	113	2	28330839
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	POLR1A MRPL28 PHKB JUP ZNF24 RNH1 TRIM56	3.43e-04	400	113	7	35013556
Pubmed	Quantitative study of the interactome of PKCζ involved in the EGF-induced tumor cell chemotaxis.	RPS5 MRPL28 RNH1 MRPL46 PROS1	3.47e-04	184	113	5	23402259
Pubmed	The zinc finger-associated SCAN box is a conserved oligomerization domain.	ZKSCAN8 ZNF24	3.71e-04	9	113	2	10567577
Pubmed	Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.	UBR1 UBR4	3.71e-04	9	113	2	17855541
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	POLR1A SHMT2 CEP192 SRBD1 JUP ZNF24 RNH1 LRP1 MIOS PYGL LRRC15	4.42e-04	1005	113	11	19615732
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	INPP4A UBR4 C15orf39 JUP LRP1 ZKSCAN4 PCNT	4.46e-04	418	113	7	34709266
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UBR1 POLR1A RPS5 MYO19 UBR4 SHMT2 NOL10 SRBD1 ECM1 JUP RNH1 PYGL WDFY3	4.60e-04	1353	113	13	29467282
Pubmed	Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction.	RYR2 CACNA1G	4.63e-04	10	113	2	32672536
Pubmed	Arrhythmogenic Right Ventricular Cardiomyopathy Overview	RYR2 JUP	4.63e-04	10	113	2	20301310
Pubmed	Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice.	PEG3 PHKB	4.63e-04	10	113	2	9060410
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	DYNC2I2 HAUS5 SHMT2 DYNC2I1 CEP192 STAT3 PHKB SIPA1L2 TRIM37 PCNT	4.78e-04	853	113	10	28718761
Pubmed	Mouse model of muscleblind-like 1 overexpression: skeletal muscle effects and therapeutic promise.	CACNA1D RYR2	5.65e-04	11	113	2	22846424
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	MAP3K1 TRIM56 TRIM37 UBE2Z	6.10e-04	118	113	4	19690564
Pubmed	Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.	CACNA1D RYR2	6.76e-04	12	113	2	23715556
Pubmed	HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.	UBR1 UBR4	6.76e-04	12	113	2	17360488
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	POLR1A RPS5 ZKSCAN8 NOL10 SRBD1 MAP3K1 RRP9 MIOS MRPL46	8.51e-04	759	113	9	35915203
Pubmed	MED12 regulates a transcriptional network of calcium-handling genes in the heart.	CACNA1D RYR2	9.28e-04	14	113	2	28724790
Pubmed	CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion.	CEP192 PCNT	9.28e-04	14	113	2	32060285
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	INPP4A UBR4 PHKB FRY TRIM56 MIOS GNL1	9.45e-04	475	113	7	31040226
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	UBR1 MYADM INPP4A INPP5B HAUS5	9.52e-04	230	113	5	35449600
Pubmed	An empirical framework for binary interactome mapping.	STK16 SLC22A6 JUP ZNF24 EXD3	9.71e-04	231	113	5	19060904
Pubmed	Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation.	CMTR1 MRPL28 RRP9 MRPL46	9.80e-04	134	113	4	28695742
Pubmed	MAP3Ks as central regulators of cell fate during development.	MAP3K6 MAP3K1	1.07e-03	15	113	2	18855897
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1D RYR2 KCNH6 CACNA1G	1.12e-03	139	113	4	16985003
Pubmed	Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.	ECM1 STAT3	1.22e-03	16	113	2	19068216
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	INPP4A RPS5 INPP5B UBR4 SHMT2 CLDN23 PIM3 TRMT44 RNH1 TRIM56 PTGDR2 PCNT	1.29e-03	1327	113	12	32694731
Pubmed	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.	SHMT2 CEP192 FRY ZNF24 PYGL	1.31e-03	247	113	5	32989298
Pubmed	Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.	UBR1 UBR4 UBA7	1.32e-03	66	113	3	24811749
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	POLR1A RPS5 UBR4 NOL10 RNH1 RRP9 PYGL PCNT	1.35e-03	653	113	8	22586326
Pubmed	Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.	ECM1 STAT3	1.38e-03	17	113	2	19861958
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	PRAG1 MAP3K6 PIM3 TRIM56 TRIM37 MOS	1.39e-03	372	113	6	22939624
Pubmed	An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.	SHMT2 STAT3 CHRNG STK16 ZNF24 RNH1 MOS	1.49e-03	514	113	7	29892012
Pubmed	UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.	ZKSCAN8 MRPL28 ZNF24 PLD1	1.68e-03	155	113	4	34921745
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	POLR1A STAT3 JUP RNH1 PYGL PLD1	1.81e-03	392	113	6	33144569
Pubmed	Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.	PRAG1 STAT3 JUP	1.90e-03	75	113	3	15951569
Pubmed	QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function.	RYR2 CACNA1G	1.91e-03	20	113	2	33397958
Pubmed	BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1.	STAT3 JUP	2.11e-03	21	113	2	11013085
Pubmed	Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.	RPS5 MAP3K6 LRRC55 SIPA1L2	2.15e-03	166	113	4	19906978
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PEG3 CEP192 NISCH RIPOR1 SIPA1L2 PCNT	2.19e-03	407	113	6	12693553
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	GNB1L UBR4 SHMT2 SRBD1 PHKB JUP RNH1	2.20e-03	551	113	7	34728620
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	SRBD1 ECM1 RRP9 MIOS MOS	2.29e-03	281	113	5	24163370
Pubmed	Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.	LINGO2 SIPA1L2	2.32e-03	22	113	2	20694011
Pubmed	Circular RNA profile in liver tissue of EpCAM knockout mice.	PHKB PYGL	2.32e-03	22	113	2	31524221
Pubmed	The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification.	ZNF24 ZKSCAN4	2.32e-03	22	113	2	31403225
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	PEG3 JUP GVINP1 MIOS PCNT	2.40e-03	284	113	5	29459677
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	POLR1A RPS5 MRPL28 SRBD1 RRP9 MRPL46	2.47e-03	417	113	6	36537216
Pubmed	A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.	NOL10 SIX1	2.53e-03	23	113	2	25217961
Pubmed	E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.	UBA7 UBE2Z	2.53e-03	23	113	2	19250909
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	LRP1 WDFY3	2.76e-03	24	113	2	17452356
Pubmed	Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.	EFCAB6 GNB1L	2.76e-03	24	113	2	11258795
Interaction	SCAND1 interactions	ZKSCAN8 ZSCAN25 ZNF24 MZF1 ZKSCAN4 ZSCAN23	1.94e-06	70	107	6	int:SCAND1
Interaction	ZHX1-C8orf76 interactions	UBR4 HAUS5 PHKB UBE2Z	1.03e-05	26	107	4	int:ZHX1-C8orf76
Interaction	ZKSCAN3 interactions	ZKSCAN8 ZNF24 ZKSCAN4 ZSCAN23	1.39e-05	28	107	4	int:ZKSCAN3
Interaction	PGBD1 interactions	ZKSCAN8 ZSCAN25 ZNF24 ZKSCAN4	1.61e-05	29	107	4	int:PGBD1
Interaction	ZNF213 interactions	ZKSCAN8 ZNF24 MZF1 ZKSCAN4	1.61e-05	29	107	4	int:ZNF213
Interaction	YJU2B interactions	UBR1 ZKSCAN8 JUP ZNF24 ZSCAN23	2.11e-05	63	107	5	int:YJU2B
Interaction	ZNF444 interactions	ZKSCAN8 ZNF24 RNH1 MZF1 NISCH ZKSCAN4	2.16e-05	106	107	6	int:ZNF444
Interaction	ZSCAN20 interactions	ZKSCAN8 ZSCAN25 ZNF24 ZKSCAN4 ZSCAN23	2.46e-05	65	107	5	int:ZSCAN20
Interaction	ZKSCAN1 interactions	ZKSCAN8 ZNF24 MZF1 ZKSCAN4 ZSCAN23	2.65e-05	66	107	5	int:ZKSCAN1
Interaction	ZNF174 interactions	ZKSCAN8 ZNF24 MZF1 ZKSCAN4 ZSCAN23	2.85e-05	67	107	5	int:ZNF174
Interaction	ZSCAN22 interactions	ZSCAN25 ZNF24 ZKSCAN4 ZSCAN23	3.08e-05	34	107	4	int:ZSCAN22
Interaction	BORCS6 interactions	HAUS5 CEP192 TRIM56 SIPA1L2 TRIM37 MOS PCNT	3.45e-05	170	107	7	int:BORCS6
Interaction	ZSCAN23 interactions	ZKSCAN8 ZNF24 ZKSCAN4 ZSCAN23	5.35e-05	39	107	4	int:ZSCAN23
Interaction	ZSCAN32 interactions	ZKSCAN8 ZNF24 ZKSCAN4 ZSCAN23	9.46e-05	45	107	4	int:ZSCAN32
Interaction	ZSCAN9 interactions	ZKSCAN8 ZNF24 ZSCAN23	1.33e-04	19	107	3	int:ZSCAN9
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR1 UBR4	3.61e-04	7	76	2	785
GeneFamily	WD repeat domain containing	DYNC2I2 GNB1L PEX7 DYNC2I1 RRP9 WDFY3	8.19e-04	262	76	6	362
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZKSCAN8 WWC2-AS2 MAP3K6 FRY ZKSCAN4 SEC14L1	6.07e-06	177	113	6	16197068260fc062bf8b730a51a199887ea580b9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MYADM RPS5 SHMT2 ECM1 LRP1 LRRC15	6.48e-06	179	113	6	68ccfe66474d049a926afc21bffa231446becc69
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic\|GI_large-bowel / Manually curated celltypes from each tissue	HK3 ECM1 LRP1 PYGL WDFY3 PLD1	8.57e-06	188	113	6	d0045fdda757d191dabc7853f6a6e99c0e97d93d
ToppCell	10x5'-GI_large-bowel-Myeloid_Monocytic-Classical_monocytes\|GI_large-bowel / Manually curated celltypes from each tissue	HK3 ECM1 LRP1 PYGL WDFY3 PLD1	8.57e-06	188	113	6	0bcf04aa47738f43c1a87dae5dc487738ee86f8c
Drug	Acemetacin [53164-05-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	INPP4A ASAP3 PODXL2 NOL10 DESI2 SIX1 HPS1 RIPOR1	5.57e-06	195	112	8	5460_DN
Drug	Lasalocid sodium salt [25999-20-6]; Up 200; 6.6uM; MCF7; HT_HG-U133A	INPP4A INPP5B ASAP3 DESI2 MAP3K1 STK16 WDFY3 LRRC15	5.79e-06	196	112	8	3360_UP
Drug	Diflunisal [22494-42-4]; Up 200; 16uM; MCF7; HT_HG-U133A	INPP5B ASAP3 NOL10 BCAN RYR2 CHRNG EXD3 HPS1	6.23e-06	198	112	8	1490_UP
Drug	Gentamicine sulfate [1405-41-0]; Down 200; 2.6uM; MCF7; HT_HG-U133A	MICAL1 INPP4A INPP5B PEX7 DESI2 MAP3K6 RYR2 RIPOR1	6.47e-06	199	112	8	7237_DN
Drug	Laudanosine (R,S) [1699-51-0]; Down 200; 11.2uM; MCF7; HT_HG-U133A	INPP4A INPP5B C15orf39 PODXL2 NOL10 SIX1 RIPOR1 SMPD2	6.47e-06	199	112	8	2890_DN
Disease	Short rib-polydactyly syndrome, Verma-Naumoff type	DYNC2I2 DYNC2I1	1.27e-04	5	106	2	C0432197
Disease	nephroblastoma (is_marker_for)	SIX1 STAT3 JUP	2.49e-04	34	106	3	DOID:2154 (is_marker_for)
Disease	immunoglobulin isotype switching measurement	UBR4 STAT3 ZSCAN23	5.36e-04	44	106	3	EFO_0010128
Disease	anxiety, stress-related disorder, major depressive disorder	ZKSCAN8 ZKSCAN4 ZSCAN23	6.11e-04	46	106	3	EFO_0005230, EFO_0010098, MONDO_0002009
Disease	Jeune thoracic dystrophy	DYNC2I2 DYNC2I1	6.88e-04	11	106	2	C0265275
Disease	sialate O-acetylesterase measurement	LINGO2 HPS1	8.24e-04	12	106	2	EFO_0803073
Disease	chronic musculoskeletal pain	ECM1 EXD3	8.24e-04	12	106	2	EFO_0022195
Disease	Short Rib-Polydactyly Syndrome	DYNC2I2 DYNC2I1	9.72e-04	13	106	2	C0036996
Disease	Saldino-Noonan Syndrome	DYNC2I2 DYNC2I1	1.13e-03	14	106	2	C0036069
Disease	Majewski Syndrome	DYNC2I2 DYNC2I1	1.13e-03	14	106	2	C0024507
Disease	Nonorganic psychosis	GNB1L KCNH6 PCNT	1.99e-03	69	106	3	C0349204
Disease	squamous cell lung carcinoma	SRBD1 PRAG1 FRY GNL1	3.01e-03	165	106	4	EFO_0000708
Disease	suicidal ideation, suicide behaviour	TMPRSS5 EXD3	3.35e-03	24	106	2	EFO_0004320, EFO_0007623

Protein segments in the cluster

Peptide	Gene	Start	Entry
RELAQRGSAACWLPL	UNC13A	1641	Q9UPW8
PEPQRLWTAICNRDL	ASAP3	546	Q8TDY4
LCLPRSELLFQQWQR	CHRNG	391	P07510
RNLWQSSRPLICLLD	GVINP1	1161	Q7Z2Y8
PLRRQELLDEWLALC	DNHD1	3456	Q96M86
LILWRVLRPECLAGA	DNHD1	4041	Q96M86
LRLINRWRLEECHPS	ANO4	626	Q32M45
ESLQQCRLPWGAERE	C7orf31	51	Q8N865
SEILCGKEIPRWINR	DESI2	116	Q9BSY9
LFWAARPLQRCGQLV	SHMT2	6	P34897
GELSPCWESLRRQIV	INPP4A	281	Q96PE3
EWLRFCLNQSLREIP	ANKRD53	121	Q8N9V6
RNLPLIRCQENGRWE	BCAN	851	Q96GW7
IALGLLYNCWQRRLP	PODXL2	516	Q9NZ53
PLLKWLRNRIQRCTA	LRRC55	206	Q6ZSA7
RQLLSQGRDLKLCLW	GNB1L	81	Q9BYB4
LLPVLGWNCLAERAA	GPR6	201	P46095
LCDRQESRPGEWLVR	HTATIP2	171	Q9BUP3
EGQLKLLLSQPRCNW	KIAA0825	796	Q8IV33
LLLSQPRCNWNLLLE	KIAA0825	801	Q8IV33
RGALTPLNQLCPWRD	MTMR11	566	A4FU01
RELRLEGNKLCSVPW	LRIT2	106	A6NDA9
QRKLVVWACLQLPRG	MYO19	881	Q96H55
EFQCRLDGLCIPLRW	LRP1	1066	Q07954
DCWPLKLGSRLEQLQ	KCNH6	816	Q9H252
ECNRLRLLLQEALWP	DYNC2I1	1046	Q8WVS4
CAWNLDRRDLRPQQP	DYNC2I2	196	Q96EX3
CWQDPLAVALSRGRQ	MAP3K6	16	O95382
CSLRGWDLRNVRQPV	PEX7	221	O00628
RRPNSICQLVLAWLG	OR56B1	201	Q8NGI3
ALCNRALTPQEGRWA	LY6L	106	H3BQJ8
RDCWIRRFPGLLINL	MANSC4	31	A6NHS7
ELCGLQARFPLSWRN	MYADM	86	Q96S97
PLACDCRLLWILQRQ	LINGO2	356	Q7L985
QCLLRLGVLRQDWPD	MICAL1	301	Q8TDZ2
LGVLRQDWPDTNRLL	MICAL1	306	Q8TDZ2
WTRALGPEQLLRACE	GNL1	281	P36915
EELCQGLSLPQWRLR	HAUS5	606	O94927
ECWDPRTRNRVGLLD	NOL10	201	Q9BSC4
PCRQLGLDQGILLNW	HK3	611	P52790
SLDRCLQVVRPVWAQ	PTGDR2	126	Q9Y5Y4
PPELQWLRAQCARLS	PCNT	1916	O95613
PRLVQNCLWTLRNLS	JUP	366	P14923
KLRNLCLDWLQPETR	PEG3	66	Q9GZU2
SLRLRIFNLNCWGIP	SMPD2	6	O60906
IPLNDQDRIPWLCNL	IDNK	51	Q5T6J7
LRWAPCEIELRQQGP	C3orf84	91	H3BNL1
QLWAGLLRNRCFLPE	CACNA1G	231	O43497
DPIESRLRKRIQGCW	EFCAB6	1311	Q5THR3
RREQCLLPPEDSRLW	COMTD1	41	Q86VU5
SWRGLQILGLECLNV	MBOAT4	206	Q96T53
PIRLIINANAVAWRC	CEP192	1531	Q8TEP8
VNNSVRLLRFELCWP	CEP192	2156	Q8TEP8
ECLRLWLSNGIQAPD	INPP5B	361	P32019
GLLLLWLPDTRCDIQ	IGKV1-27	11	A0A075B6S5
LTFINDLCGPRRNIW	ECM1	466	Q16610
LRQIRECRSLWPNDI	FRY	2921	Q5TBA9
QLRRLRLQGNPLWCG	CHADL	301	Q6NUI6
CQARPLLEWLARARV	CHADL	316	Q6NUI6
LARDPLAWENLQCLR	FDXACB1	41	Q9BRP7
CLPLWQGINLVLLTR	HPS1	371	Q92902
NLGPLEEIEFWRNRC	DNAH2	271	Q9P225
LTPLQESCLIRLRQW	SEC14L1	251	Q92503
WLPRDRQGQPESCLR	SLC22A6	66	Q4U2R8
PWRSLQQLLLLCAGI	SLC39A13	346	Q96H72
ISERQGWLVQCLDPL	RYR2	1611	Q92736
LNNPIRRACISIVEW	CACNA1D	111	Q01668
LLASLGVRCWQDEPN	CLDN23	96	Q96B33
PRQAEIRKECLRLWG	CMTR1	526	Q8N1G2
IRKECLRLWGIPDQA	CMTR1	531	Q8N1G2
LWPALQELARCGNLA	FTCD	461	O95954
LLDILQPQQNGRCWL	PHKB	911	Q93100
QRLGDVIQRCWRPSA	MOS	311	P00540
WQELLGRLCLIDRLL	MAP3K1	751	Q13233
RCRNPEWGLRDTALL	METTL26	161	Q96S19
VSPLRRVNQAIWLLC	RPS5	141	P46782
NGSPWRLLGALCLQR	MRPL46	41	Q9H2W6
APLQLRELVNCRWAE	TRIM37	56	O94972
VWLERPQVANKRLCG	TRMT44	26	Q8IYL2
LQLKWQRSLCEPGEA	POLR1A	1196	O95602
TEDQILWLLLGICRG	STK16	121	O75716
RCDSDILPLRNWLLL	LRRC15	426	Q8TF66
RPVVEGNRWRLDCIL	PLD1	391	Q13393
NLLGDELLECLSWRR	RIMOC1	121	A6NDU8
LEESRLERGIRPWNC	SIPA1L2	311	Q9P2F8
NLERLGRFLWSLPAC	SIX1	26	Q15475
ARGLWILCQALENPN	NLRP7	916	Q8WX94
CLQPEQSLRLRWGPD	SYCE2	161	Q6PIF2
PINPRLDGCIRSWNL	PROS1	441	P07225
RTNIEPWVCANIIRL	SRBD1	221	Q8N5C6
KDNPRRGLWLANCQR	THAP7	31	Q9BT49
DLLGLQWRDCVRRQL	C15orf39	911	Q6ZRI6
QRAEPQRICRALWLT	LINC02915	16	Q8N8G6
ALEQAPILCRALRWG	nan	121	Q8NFD4
PILCRALRWGLTQFL	nan	126	Q8NFD4
SQLRELCRLWLRPET	ZNF24	71	P17028
QIECELLRERGLWGP	WDFY3	2346	Q8IZQ1
LNEERILALQLCGWI	MIOS	486	Q9NXC5
LGVLRVRPQNWQDCV	UBA7	656	P41226
RLWQCGEGFRQLDLL	RRP9	401	O43818
PNICLDRLENWITSL	STAT3	256	P40763
PQEALRELQELCRRW	ZSCAN25	56	Q6NSZ9
LARQWEALCGRELPV	NISCH	1486	Q9Y2I1
LEAQVRDQPRWLLVC	TMPRSS5	121	Q9H3S3
VRPLLQRWCADPALL	UBR1	1561	Q8IWV7
SDARWAELLPLLQQC	RNH1	16	P13489
WKRLQLREGICSRLP	MRPL28	11	Q13084
CQQLIRWCLSLRPSE	PIM3	266	Q86V86
VGLCLNLRNLPWFDE	TTLL3	106	Q9Y4R7
AKRVLQCLLWGPRRE	PRAG1	1321	Q86YV5
WDGERTAPQCLLRIK	UBE2Z	91	Q9H832
NLRWRLPLTCLLLQV	RHCG	6	Q9UBD6
LSRLRELCGQWLQPE	ZKSCAN4	71	Q969J2
PREALSQLRELCRQW	ZBED9	66	Q6R2W3
SQLRELCRQWLNPEI	ZBED9	71	Q6R2W3
FLPRWKCEQLIRQGV	GINS1	176	Q14691
LACVEPVRLQAWLTR	UBR4	1456	Q5T4S7
GPLRCQEAWALERLL	RIPOR1	921	Q6ZS17
RWLLLCNPGLAELIA	PYGL	491	P06737
IQQLLRTCWPALPRD	WWC2-AS2	126	Q96NR7
QLRALCHQWLRPDLN	ZKSCAN8	71	Q15776
GAIAQRLRQLQGCPW	TRIM56	326	Q9BRZ2
LQRLQELCHQWLRPE	ZSCAN23	66	Q3MJ62
LSNWDRRPLCEEQVI	EXD3	536	Q8N9H8
ALAQLRELCRQWLRP	MZF1	61	P28698