Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	neuron degeneration	MPV17 ANK1 KIF1A CDH23 GJC2 DST CLCN2 ALMS1 GPR75 HERC1 NOS2	7.98e-06	391	76	11	MP:0003224
MousePheno	cochlear ganglion hypoplasia	MPV17 CDH23 FGF3	2.47e-05	11	76	3	MP:0003637
MousePheno	neurodegeneration	MPV17 ANK1 KIF1A CDH23 GJC2 DST CLCN2 ALMS1 GPR75 HERC1 NOS2	4.23e-05	468	76	11	MP:0002229
Domain	DMAP_binding	DIP2B DIP2A DIP2C	1.57e-06	5	102	3	PF06464
Domain	-	DSP DST PLEC	3.13e-06	6	102	3	3.90.1290.10
Domain	DMAP1-bd	DIP2B DIP2A DIP2C	3.13e-06	6	102	3	IPR010506
Domain	DMAP_binding	DIP2B DIP2A DIP2C	3.13e-06	6	102	3	SM01137
Domain	Plectin	DSP DST PLEC	5.45e-06	7	102	3	PF00681
Domain	Plectin_repeat	DSP DST PLEC	5.45e-06	7	102	3	IPR001101
Domain	PLEC	DSP DST PLEC	5.45e-06	7	102	3	SM00250
Domain	Spy1	SPDYE2 SPDYE2B SPDYE6	2.53e-05	11	102	3	PF11357
Domain	Speedy	SPDYE2 SPDYE2B SPDYE6	2.53e-05	11	102	3	IPR020984
Domain	2-oxogl_dehyd_N	OGDH OGDHL	2.95e-05	2	102	2	IPR032106
Domain	2-oxogl_dehyd_N	OGDH OGDHL	2.95e-05	2	102	2	PF16078
Domain	2oxoglutarate_DH_E1	OGDH OGDHL	8.83e-05	3	102	2	IPR011603
Domain	KGD_C	OGDH OGDHL	8.83e-05	3	102	2	IPR031717
Domain	OxoGdeHyase_C	OGDH OGDHL	8.83e-05	3	102	2	PF16870
Domain	Kinesin-like_KIF1-typ	KIF1A KIF1B	1.76e-04	4	102	2	IPR022140
Domain	KIF1B	KIF1A KIF1B	1.76e-04	4	102	2	PF12423
Domain	Kinesin_assoc	KIF1A KIF1B	4.37e-04	6	102	2	PF16183
Domain	E1_dh	OGDH OGDHL	4.37e-04	6	102	2	PF00676
Domain	DH_E1	OGDH OGDHL	4.37e-04	6	102	2	IPR001017
Domain	Kinesin-like	KIF1A KIF1B	4.37e-04	6	102	2	IPR022164
Domain	Kinesin_assoc	KIF1A KIF1B	4.37e-04	6	102	2	IPR032405
Domain	DUF3694	KIF1A KIF1B	4.37e-04	6	102	2	PF12473
Domain	Spectrin_repeat	DSP DST PLEC	5.21e-04	29	102	3	IPR002017
Domain	AMP-binding	DIP2B DIP2A DIP2C	5.77e-04	30	102	3	PF00501
Domain	AMP-dep_Synth/Lig	DIP2B DIP2A DIP2C	5.77e-04	30	102	3	IPR000873
Domain	SPEC	DSP DST PLEC	6.99e-04	32	102	3	SM00150
Domain	Spectrin/alpha-actinin	DSP DST PLEC	6.99e-04	32	102	3	IPR018159
Domain	Transketolase-like_Pyr-bd	OGDH OGDHL	8.09e-04	8	102	2	IPR005475
Domain	Transket_pyr	OGDH OGDHL	8.09e-04	8	102	2	SM00861
Domain	Transket_pyr	OGDH OGDHL	8.09e-04	8	102	2	PF02779
Domain	ANF_lig-bd_rcpt	NPR2 GRM2 GUCY2C	1.07e-03	37	102	3	IPR001828
Domain	ANF_receptor	NPR2 GRM2 GUCY2C	1.07e-03	37	102	3	PF01094
Domain	Peripla_BP_I	NPR2 GRM2 GUCY2C	1.25e-03	39	102	3	IPR028082
Domain	DUF4599	SPATA31A7 SPATA31A6	1.88e-03	12	102	2	PF15371
Domain	DUF4599	SPATA31A7 SPATA31A6	1.88e-03	12	102	2	IPR027970
Domain	THDP-binding	OGDH OGDHL	2.22e-03	13	102	2	IPR029061
Domain	-	OGDH OGDHL	2.22e-03	13	102	2	3.40.50.970
Domain	A/G_cyclase_CS	NPR2 GUCY2C	3.81e-03	17	102	2	IPR018297
Domain	-	NPR2 GUCY2C	4.27e-03	18	102	2	3.30.70.1230
Domain	Nucleotide_cyclase	NPR2 GUCY2C	4.27e-03	18	102	2	IPR029787
Domain	Guanylate_cyc	NPR2 GUCY2C	4.75e-03	19	102	2	PF00211
Domain	GUANYLATE_CYCLASE_2	NPR2 GUCY2C	4.75e-03	19	102	2	PS50125
Domain	A/G_cyclase	NPR2 GUCY2C	4.75e-03	19	102	2	IPR001054
Domain	GUANYLATE_CYCLASE_1	NPR2 GUCY2C	4.75e-03	19	102	2	PS00452
Domain	CYCc	NPR2 GUCY2C	4.75e-03	19	102	2	SM00044
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	DIP2B DDX19A CAMLG DNAJA2 POLR2B OGDH MICU1 DIP2A PTPN14 DST ALMS1 CSNK1D IMP4 PEX5 OGDHL MINDY4 HERC1 BAG6 DDX28 STOML2 FTSJ3	3.54e-09	1496	105	21	32877691
Pubmed	CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1.	DIP2B DIP2A DIP2C	2.67e-08	3	105	3	17236128
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	KRT72 DSP DNAJA2 DLGAP4 KIF1B RPS17 GJC2 ZNFX1 GRM2 OGDH SHANK3 DIP2A DST CSNK1D AMOT OGDHL PLEC STOML2	2.75e-07	1431	105	18	37142655
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DIP2B HIVEP1 DSP KIF1B RICTOR PRAG1 NEDD4 PTPN14 DST ALMS1 CSNK1D AMOT N4BP2 PLEC	3.34e-07	861	105	14	36931259
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A7 SPATA31A6 SPATA31A1	5.31e-07	6	105	3	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A7 SPATA31A6 SPATA31A1	5.31e-07	6	105	3	25930072
Pubmed	Autism candidate gene DIP2A regulates spine morphogenesis via acetylation of cortactin.	DIP2B SHANK3 DIP2A DIP2C	1.52e-06	28	105	4	31600191
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	DSP DNAJA2 POLR2B KIF1B PTPN14 ALMS1 CSNK1D N4BP2 NFKBIE PEX5 MINDY4 PLEC FTSJ3	1.86e-06	853	105	13	28718761
Pubmed	Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.	SPDYE2 SPDYE2B SPDYE6	2.22e-06	9	105	3	36272447
Pubmed	Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.	DSP DST PLEC	2.22e-06	9	105	3	12482924
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	HIVEP1 DSP KIF1B OBSCN ANKRD50 DST ALMS1 AMOT HOOK2 PLEC	2.79e-06	497	105	10	23414517
Pubmed	Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.	DSP DST PLEC	4.33e-06	11	105	3	12802069
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	DIP2B KIF1A KIF1B CBLB PRAG1 PEX5 STOML2	4.67e-06	218	105	7	33378226
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DIP2B DNAJA2 DLGAP4 HCN3 SH3BP1 ZNFX1 GRM2 SHANK3 NEDD4 DST N4BP2 PEX5 STOML2	6.91e-06	963	105	13	28671696
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	DLGAP4 CDH23 ZNFX1 RUNX1T1 AMOT PLEC	7.11e-06	152	105	6	34299191
Pubmed	Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.	SPDYE2 SPDYE2B SPDYE6	7.48e-06	13	105	3	15611625
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	KRT72 DSP DNAJA2 POLR2B OBSCN SHANK3 GUCY2C HOOK2 PLEC DDX28	8.44e-06	564	105	10	21565611
Pubmed	Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres.	ANK1 OBSCN	9.03e-06	2	105	2	19002483
Pubmed	Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog.	DIP2A DIP2C	9.03e-06	2	105	2	12137943
Pubmed	Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression.	RICTOR NAA25	9.03e-06	2	105	2	26600389
Pubmed	Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling.	CAMLG PKHD1	9.03e-06	2	105	2	16243292
Pubmed	The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors.	KIF1A KIF1B	9.03e-06	2	105	2	7539720
Pubmed	Obscurin is a ligand for small ankyrin 1 in skeletal muscle.	ANK1 OBSCN	9.03e-06	2	105	2	12631729
Pubmed	E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity.	CBLB NEDD4	9.03e-06	2	105	2	22763434
Pubmed	TFAP2C regulates carbonic anhydrase XII in human breast cancer.	CA9 TFAP2C	9.03e-06	2	105	2	31636386
Pubmed	WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation.	CBLB NEDD4	9.03e-06	2	105	2	12907674
Pubmed	Mapping the binding site on small ankyrin 1 for obscurin.	ANK1 OBSCN	9.03e-06	2	105	2	17720975
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DIP2B KIF1A KIF1B OBSCN ZNF236 OGDH PLEKHM1 DNAH1 MICU1 CSNK1D LRRC27 RBM6 DIP2C SEMA6A HOOK2 FAM149A	1.01e-05	1489	105	16	28611215
Pubmed	Characterization of a new family of cyclin-dependent kinase activators.	SPDYE2 SPDYE2B SPDYE6	1.76e-05	17	105	3	15574121
Pubmed	Bioinformatics and cellular signaling.	TRAF3IP2 HIVEP1 CAMLG CBLB PEX5 BAG6	1.98e-05	182	105	6	15102471
Pubmed	Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.	DNAJA2 POLR2B RPS17 RICTOR STOML2	2.27e-05	111	105	5	32683582
Pubmed	BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks.	KIF1A KIF1B	2.70e-05	3	105	2	27851960
Pubmed	Evolution of the Cdk-activator Speedy/RINGO in vertebrates.	SPDYE2 SPDYE6	2.70e-05	3	105	2	22763696
Pubmed	BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin.	DST PLEC	2.70e-05	3	105	2	19932097
Pubmed	Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles.	ANK1 OBSCN	2.70e-05	3	105	2	12527750
Pubmed	In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport.	KIF1A KIF1B	2.70e-05	3	105	2	23404705
Pubmed	PTPN14 is required for the density-dependent control of YAP1.	PTPN14 CSNK1D AMOT	3.42e-05	21	105	3	22948661
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	HIVEP1 DSP DST ALMS1 ZFHX4 AMOT N4BP2 PLEC	4.11e-05	418	105	8	34709266
Pubmed	The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.	NPR2 GUCY2C NOS2	4.53e-05	23	105	3	17954614
Pubmed	Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.	SPATA31A7 SPATA31A6 SPATA31A1	5.17e-05	24	105	3	32212159
Pubmed	The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.	CAMLG POLR2B RPS17 BAG6	5.19e-05	67	105	4	22046132
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	PCED1A HIVEP1 DLGAP4 SHANK3 PLEKHM1 CSNK1D PEX5 GPSM2 HOOK2	5.21e-05	560	105	9	21653829
Pubmed	Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons.	HCN3 SHANK3	5.40e-05	4	105	2	26966193
Pubmed	Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover.	ANK1 OBSCN	5.40e-05	4	105	2	22573887
Pubmed	The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function.	KIF1A KIF1B	5.40e-05	4	105	2	27263974
Pubmed	Role of binding of plectin to the integrin beta4 subunit in the assembly of hemidesmosomes.	DST PLEC	5.40e-05	4	105	2	14668477
Pubmed	Molecular interactions with obscurin are involved in the localization of muscle-specific small ankyrin1 isoforms to subcompartments of the sarcoplasmic reticulum.	ANK1 OBSCN	5.40e-05	4	105	2	16962094
Pubmed	AP-2δ is a crucial transcriptional regulator of the posterior midbrain.	TFAP2C FGF3 PAX5	5.86e-05	25	105	3	21858141
Pubmed	Proteomic analysis of the NOS2 interactome in human airway epithelial cells.	DNAJA2 RPS17 PLEC HERC1 NOS2	6.42e-05	138	105	5	23438482
Pubmed	KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.	KIF1A KIF1B	8.97e-05	5	105	2	18849981
Pubmed	Immediate early gene X-1 interacts with proteins that modulate apoptosis.	CAMLG BAG6	8.97e-05	5	105	2	15451437
Pubmed	The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy.	PTPN14 AMOT	8.97e-05	5	105	2	32292505
Pubmed	The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.	NEDD4 AMOT	8.97e-05	5	105	2	22385262
Pubmed	Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase.	NEDD4 N4BP2	8.97e-05	5	105	2	11717310
Pubmed	Mechanistic insights into PTS2-mediated peroxisomal protein import: the co-receptor PEX5L drastically increases the interaction strength between the cargo protein and the receptor PEX7.	ACAA1 PEX5	8.97e-05	5	105	2	25538232
Pubmed	The G protein-coupled receptor repertoires of human and mouse.	GPR20 GPR173 GRM2 GPR148	9.90e-05	79	105	4	12679517
Pubmed	The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.	SH3BP1 PRAG1 NEDD4 PLEC	1.09e-04	81	105	4	20697350
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	NR2F6 OBSCN ZNF236 PRAG1 PLEKHM1 CPTP DIP2A DST DIP2C OGDHL PLEC HERC1	1.29e-04	1105	105	12	35748872
Pubmed	Mouse models of human ocular disease for translational research.	CLCN2 ALMS1	1.34e-04	6	105	2	28859131
Pubmed	Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.	DIP2B SHANK3 PLEC	1.63e-04	35	105	3	23969696
Pubmed	The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.	DST PLEC	1.88e-04	7	105	2	10637308
Pubmed	Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.	NPR2 CORIN	1.88e-04	7	105	2	19326473
Pubmed	SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway.	NEDD4 CSNK1D	1.88e-04	7	105	2	24657926
Pubmed	Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock.	RSPO3 CORIN	1.88e-04	7	105	2	33037205
Pubmed	Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.	DLGAP4 SHANK3	1.88e-04	7	105	2	10527873
Pubmed	Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.	PAX5 NOS2	2.50e-04	8	105	2	22474389
Pubmed	Epidermolysis Bullosa Simplex	DST PLEC	2.50e-04	8	105	2	20301543
Pubmed	Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation.	DSP AMOT	2.50e-04	8	105	2	17576135
Pubmed	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	KIF1A KIF1B	2.50e-04	8	105	2	25818806
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	DLGAP4 RICTOR ANKRD50 CBLB PTPN14 DST SEMA6A	2.98e-04	421	105	7	36976175
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	KLF12 ZBTB6 HIVEP1 KIF1A KIF1B TFAP2C ZNF358 NFKBIE PAX5	3.05e-04	709	105	9	22988430
Pubmed	Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.	CBLB NEDD4	3.21e-04	9	105	2	14973438
Pubmed	Plakin proteins are coordinately cleaved during apoptosis but preferentially through the action of different caspases.	DSP PLEC	3.21e-04	9	105	2	15500642
Pubmed	Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear.	ALMS1 GPSM2	3.21e-04	9	105	2	28346477
Pubmed	Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists.	NFKBIE NOS2	3.21e-04	9	105	2	20711808
Pubmed	A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities.	MPV17 PEX5 NOS2	3.24e-04	44	105	3	20178365
Pubmed	Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse.	ACAA1 PEX5	4.00e-04	10	105	2	11171065
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	KRT72 DSP DNAJA2 POLR2B RPS17 MICU1 PTPN14 DST CSNK1D IMP4 PLEC FTSJ3	4.17e-04	1257	105	12	36526897
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	HIVEP1 DSP DNAJA2 KIF1B PTPN14 ALMS1 N4BP2 RBM6	4.22e-04	588	105	8	38580884
Pubmed	Functional proteomics mapping of a human signaling pathway.	ZBTB6 HIVEP1 CBLB NEDD4 DST PLEC HERC1 BAG6	4.37e-04	591	105	8	15231748
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	KLF12 ZBTB6 CAMLG POLR2B OBSCN RICTOR ANKRD50 AMOT OGDHL PLEC HERC1	4.42e-04	1084	105	11	11544199
Pubmed	mTORC1 activity is essential for erythropoiesis and B cell lineage commitment.	RICTOR PAX5	4.88e-04	11	105	2	31729420
Pubmed	The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.	DST PLEC	4.88e-04	11	105	2	10811835
Pubmed	Current insights into the formation and breakdown of hemidesmosomes.	DST PLEC	4.88e-04	11	105	2	16757171
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	DNAJA2 POLR2B OGDH ZNF358 IMP4 RBM6 OGDHL DDX28 FTSJ3	4.99e-04	759	105	9	35915203
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	MPV17 DIP2B HIVEP1 ZNF236 NEDD4 MICU1 ZNF12 DIP2A CSNK1D IMP4	4.99e-04	925	105	10	28986522
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	KIF1A DSP CAMLG DNAJA2 KIF1B ZNFX1 MICU1 DIP2A NAA25 DST GPSM2 PLEC	5.07e-04	1285	105	12	35914814
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	DSP OBSCN OGDH SHANK3 DST PLEC	5.19e-04	331	105	6	29199018
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CAMLG DNAJA2 POLR2B RICTOR OGDH MICU1 DIP2A PTPN14 N4BP2 SEMA6A BAG6 STOML2 FTSJ3	5.46e-04	1487	105	13	33957083
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	DSP DNAJA2 POLR2B OGDH PLEC	5.48e-04	219	105	5	31353912
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DIP2B NR2F6 HIVEP1 DSP KIF1B RICTOR RBM6 PLEC BAG6	5.74e-04	774	105	9	15302935
Pubmed	Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.	OGDH OGDHL	5.84e-04	12	105	2	25438054
Pubmed	Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.	KIF1A KIF1B	5.84e-04	12	105	2	16301330
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	DDX19A ACAA1 KIF1A DSP DNAJA2 AMOT NFKBIE PLEC STOML2	6.40e-04	786	105	9	29128334
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	ZNFX1 DST ALMS1 SEMA6A	6.65e-04	130	105	4	12421765
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	DSP CAMLG DNAJA2 DLGAP4 RICTOR ZNFX1 OGDH SHANK3 MICU1 PLEC STOML2	6.66e-04	1139	105	11	36417873
Pubmed	Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.	CBLB NEDD4	6.89e-04	13	105	2	12218189
Pubmed	Glutamatergic Dysfunction and Synaptic Ultrastructural Alterations in Schizophrenia and Autism Spectrum Disorder: Evidence from Human and Rodent Studies.	SHANK3 DIP2A	6.89e-04	13	105	2	33374598
Pubmed	Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function.	DST PLEC	6.89e-04	13	105	2	22962592
Pubmed	Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.	DST PLEC	6.89e-04	13	105	2	9670011
GeneFamily	EF-hand domain containing\|Plakins	DSP DST PLEC	2.45e-06	8	65	3	939
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE2 SPDYE2B SPDYE6	9.53e-06	12	65	3	756
GeneFamily	G protein-coupled receptors, Class A orphans	GPR20 GPR173 GPR75 GPR148	1.78e-04	78	65	4	262
GeneFamily	Guanylate cyclase receptors	NPR2 GUCY2C	2.64e-04	7	65	2	343
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANK1 GJC2 CBLB RSPO3 PTPN14 PLEC	3.25e-06	171	105	6	686f95892c3909973c66c9a27159a070a068f175
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANK1 GJC2 CBLB RSPO3 PTPN14 PLEC	3.25e-06	171	105	6	f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCell	PND14-Endothelial-Endothelial_lymphatic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANK1 GJC2 CBLB RSPO3 PTPN14 PLEC	3.25e-06	171	105	6	d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANK1 GJC2 CBLB RSPO3 PTPN14 PLEC	3.25e-06	171	105	6	fbf8e9db00573adcada4b25730e191417b7c9999
ToppCell	3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GJC2 RUNX1T1 SHANK3 PTPN14 DST SEMA6A	4.10e-06	178	105	6	ad3de3e03a401dac64431a541899445262246347
ToppCell	5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GJC2 RUNX1T1 SHANK3 PTPN14 DST SEMA6A	4.81e-06	183	105	6	4d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 OBSCN PKD1L2 DNAH1 ZFHX4 PKHD1	4.96e-06	184	105	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 OBSCN PKD1L2 DNAH1 ZFHX4 PKHD1	4.96e-06	184	105	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK1 OBSCN PKD1L2 DNAH1 ZFHX4 PKHD1	4.96e-06	184	105	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	pdx-Tumor_cells-T9\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	HIVEP1 POLR2B ZNFX1 PRAG1 PTPN14	2.34e-05	144	105	5	0b94d978262a826c9254145aa98c6c30240243f9
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KRT72 GJC2 RSPO3 DIP2A MINDY4	2.67e-05	148	105	5	065177aaa63c0441d312260b43ecdac78c84ad03
ToppCell	368C-Fibroblasts-Fibroblast-H-\|368C / Donor, Lineage, Cell class and subclass (all cells)	GPR173 ZNF12 AMOT DIP2C GPSM2	3.03e-05	152	105	5	dbfb4d4de36ef9f5c7da1950baa915b12788685e
ToppCell	368C-Fibroblasts-Fibroblast-H\|368C / Donor, Lineage, Cell class and subclass (all cells)	GPR173 ZNF12 AMOT DIP2C GPSM2	3.03e-05	152	105	5	9f3682da00fd627e80aa820ecc6f5fed23b9738a
ToppCell	facs-MAT-Fat-24m-Myeloid-macrophage\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR2F6 PKD1L2 NFKBIE FUT7 PLD4	3.33e-05	155	105	5	d0c1608f8f6b6f4174e51d610501c707cba5e015
ToppCell	normal_Lung-Fibroblasts-Mesothelial_cells\|Fibroblasts / Location, Cell class and cell subclass	CA9 DSP TFAP2C GPR75 OGDHL	4.75e-05	167	105	5	892a2dc83ab5de5a1016402f8e95d2aabf651326
ToppCell	facs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-myeloid_dendritic_type_1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CA9 NR2F6 NFKBIE FUT7 PLD4	5.17e-05	170	105	5	6686d1797988216c0d9417f21a2537369abce410
ToppCell	368C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	RICTOR ZNF469 NAA25 FUT7 PLD4	5.31e-05	171	105	5	714a0b0d0c9886fef64170cf53eb64f0d8a47280
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJC2 PRAG1 PTPN14 HHIPL2 SEMA6A	5.46e-05	172	105	5	b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCell	Endothelial-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	RUNX1T1 SHANK3 PTPN14 ZFHX4 SEMA6A	5.46e-05	172	105	5	d4e98ff9c7cbc95457e1d71fa60f151a2f178dae
ToppCell	facs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GJC2 PRAG1 PTPN14 HHIPL2 SEMA6A	5.46e-05	172	105	5	2f1673fcb2356684d60871debb0f159aec553a1c
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZBTB6 HIVEP1 PAX5 FUT7 PLD4	5.93e-05	175	105	5	87e557f7508c88b2087db5d57e77d5e2c92ca083
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	KIF1A RICTOR DST DIP2C HERC1	6.26e-05	177	105	5	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAA1 HCN3 DNAH1 RSPO3 GPRIN2	6.60e-05	179	105	5	479116ac65488c60104a053530830763ec1f95b2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAA1 HCN3 DNAH1 RSPO3 GPRIN2	6.60e-05	179	105	5	1dfc0cb8b369aef35c59f3d4c52603dc9f3728c1
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACAA1 HCN3 DNAH1 RSPO3 GPRIN2	6.60e-05	179	105	5	69a1b3b05c921de6343ffe6ad998aa2b804312a7
Disease	oxoglutarate dehydrogenase deficiency (implicated_via_orthology)	OGDH OGDHL	1.00e-05	2	94	2	DOID:0081326 (implicated_via_orthology)
Disease	synucleinopathy (biomarker_via_orthology)	KIF1A KIF1B	6.00e-05	4	94	2	DOID:0050890 (biomarker_via_orthology)
Disease	neuroticism measurement	HIVEP1 PRAG1 PLEKHM1 PTPN14 LRRC27 PKHD1 DIP2C PAX5 HOOK2 HERC1 BAG6	1.50e-04	909	94	11	EFO_0007660
Disease	Malignant neoplasm of breast	NR2F6 ANK1 OBSCN NEDD4 RSPO3 NAA25 PTPN14 CSNK1D N4BP2 DIP2C FGF3 NOS2	1.56e-04	1074	94	12	C0006142
Disease	epidermolysis bullosa simplex (is_implicated_in)	DST PLEC	2.09e-04	7	94	2	DOID:4644 (is_implicated_in)
Disease	electrocardiography	KLF12 HIVEP1 OBSCN ZNFX1 RSPO3 ZNF358 RBM6 PLEC	2.96e-04	530	94	8	EFO_0004327
Disease	Oxidative Phosphorylation Deficiencies	MPV17 NOS2	3.56e-04	9	94	2	C0949856
Disease	Mitochondrial Respiratory Chain Deficiencies	MPV17 NOS2	3.56e-04	9	94	2	C0949857
Disease	Electron Transport Chain Deficiencies, Mitochondrial	MPV17 NOS2	3.56e-04	9	94	2	C0949855
Disease	chronotype measurement	HIVEP1 RUNX1T1 PRAG1 DNAH1 NAA25 PKHD1 RBM6 DIP2C SEMA6A PAX5	5.08e-04	882	94	10	EFO_0008328
Disease	nervous system disease (implicated_via_orthology)	KIF1A KIF1B	6.49e-04	12	94	2	DOID:863 (implicated_via_orthology)
Disease	Ischemic stroke, fibrinogen measurement	DIP2B SHANK3 PLEC	7.28e-04	55	94	3	EFO_0004623, HP_0002140
Disease	Alzheimer's disease (implicated_via_orthology)	HIVEP1 DNAJA2 NOS2	8.09e-04	57	94	3	DOID:10652 (implicated_via_orthology)
Disease	fibrinogen measurement, factor VII measurement	DIP2B SHANK3 PLEC	8.51e-04	58	94	3	EFO_0004619, EFO_0004623
Disease	Arthritis, Psoriatic	TRAF3IP2 NOS2	8.91e-04	14	94	2	C0003872
Disease	bipolar disorder, body mass index	CDH23 RUNX1T1 PKHD1	1.59e-03	72	94	3	EFO_0004340, MONDO_0004985
Disease	psoriatic arthritis	TRAF3IP2 NOS2 BAG6	2.73e-03	87	94	3	EFO_0003778
Disease	serum albumin measurement	MPV17 HIVEP1 SH3BP1 CBLB PLEKHM1 RSPO3 PLEC	2.87e-03	592	94	7	EFO_0004535

Protein segments in the cluster

Peptide	Gene	Start	Entry
LNSNAMPRLRVGIGR	PTRH1	151	Q86Y79
HLMKRIQRGPVRGIS	RPS17	56	P08708
MPCRLLHQRETRSGG	nan	1	Q6ZR03
EQRINRIMGFHRPGS	CAMLG	41	P49069
RLNPGKMHQDEGLRD	AMOT	151	Q4VCS5
HRLNQPGRTEGQLMR	AMOT	266	Q4VCS5
RPHLGGRNEMAARKN	TFAP2C	336	Q92754
NGRIRRMSRGVNPSL	BAG6	896	P46379
MRGSRHNGLRVVIPP	ANK1	926	P16157
GPVNEHRGIQRLEAM	GRM2	51	Q14416
PGLLHQGRQRRVRAM	GPR20	226	Q99678
LHRMRQLAQTGSLGR	SH3BP1	6	Q9Y3L3
RQGHQNRMCPLPKRV	ALMS1	4086	Q8TCU4
RNGQRHAPEIARMAL	NPR2	921	P20594
LGRVSVPRTMQDRGH	ANKRD50	1376	Q9ULJ7
RIHVSNGLLMRGPRP	CDH23	1151	Q9H251
GLMTLGRQAERSQPR	DLGAP4	226	Q9Y2H0
FLVQMRRQHRRGTKG	CA9	431	Q16790
MRKEAVQRGRIPHSL	NR2F6	121	P10588
MVASGLPKRNGNRHA	GUCY2C	876	P25092
LVFPGAQRMNRGRHE	IMP4	106	Q96G21
GHSLPGRDFLRKQMR	PAX5	211	Q02548
RLHDSQHKGVRGGRM	NOS2	996	P35228
KRMGTRRGRHEQSPT	C22orf15	126	Q8WYQ4
LNGVRPKLGRRHSME	GPSM2	396	P81274
RPHSQMNKNHGILRR	NEDD4	441	P46934
RGRHLQNRVLSAMPD	FAM149A	681	A5PLN7
RDLRDRNRPMGLHGT	RUNX1T1	321	Q06455
RNRPMGLHGTRQEEM	RUNX1T1	326	Q06455
GQHDGRRRIQREGLM	GJC2	196	Q5T442
LPREKGRMRFHRLQN	DST	81	Q03001
LAQENAGLRERMGRP	HOOK2	211	Q96ED9
DTGSPGMQRRRRKIL	KIF1B	1451	O60333
MNQRRSESRPGNHRL	NFKBIE	1	O00221
RDHEMVRQLQSGLPR	FGF3	186	P11487
RHGQLAEAGRNVMVP	HERC1	4006	Q15751
NGRHSRVGSDPVLMR	CBLB	626	Q13191
HGGSQPIQIRRRLMM	MICU1	21	Q9BPX6
NVILGMPHRGRLNVL	OGDHL	291	Q9ULD0
EALNMQRKSRGPRGE	PEX5	581	P50542
MGGPCRQRLRHSERL	PCED1A	421	Q9H1Q7
ERKVSMRLHRGAPVN	CSNK1D	366	P48730
MNNAGHGPTRRLRGL	FUT7	1	Q11130
DLEGGHGMRRIRLQL	DDX28	236	Q9NUL7
HGMRRIRLQLSRQPS	DDX28	241	Q9NUL7
PINSRGEKQRMHLRD	DIP2B	1546	Q9P265
QHDRDMARGVRGRAP	HCN3	576	Q9P1Z3
ARLQGVSNMRKLGHL	RICTOR	46	Q6R327
LHRLRMVLGKQPNRT	GPR75	141	O95800
LPGMKRRRQGHIVVI	RDH8	126	Q9NYR8
DRETQKLMGPGRHRL	PKD1L2	411	Q7Z442
GLEQEGTVHRLMLRR	OBSCN	2426	Q5VST9
RQVPMGRLTRGVLHS	PLD4	201	Q96BZ4
IMGMPHRGRLNVLAN	OGDH	306	Q02218
SRNGRRRGEDMMHPL	DNAJA2	106	O60884
PLIQGLRNPGMRIRH	DNAH1	1096	Q9P2D7
LRIMERLRGGPQSEH	CPTP	61	Q5TA50
GSHPRINTLGRMIRA	DSP	6	P15924
QLLGMVRGHLPSRRH	GPR148	326	Q8TDV2
PINSRGEKQRMHLRD	DIP2C	1526	Q9Y2E4
ARMNKRILGGRTSRP	CORIN	796	Q9Y5Q5
IRQNGHAASRRLLGM	GPR173	261	Q9NS66
HARGLKMLERVRSQP	KHDC1L	96	Q5JSQ8
HGKAQMDPRGLSPRQ	KLF12	221	Q9Y4X4
PINSRGEKQRMHLRD	DIP2A	1541	Q14689
GHQDQSIRIQRMLPR	DDX19A	251	Q9NUU7
HSGRMRPSAEQKRAG	HHIPL2	706	Q6UWX4
EGRRGPLRAVMQSLR	GPRIN2	431	O60269
HVADAGSPGMQRRRR	KIF1A	1331	Q12756
SRMQRGGLRLHRSLQ	IER2	21	Q9BTL4
LRRSHELQGMGKPGR	OR1N2	6	Q8NGR9
PPRMQDLIHGQESRR	NRIP2	136	Q9BQI9
VHRRQMGLSNPFRGL	PLEKHM1	521	Q9Y4G2
NVRIIKNRTGPMGHT	RBM6	686	P78332
MQRLQVVLGHLRGPA	ACAA1	1	P09110
QRRFHGQAPLEEMRK	LRRC27	451	Q9C0I9
MKNHSLRAGRECPRG	SPATA31A6	76	Q5VVP1
MKNHSLRAGRECPRG	SPATA31A7	76	Q8IWB4
LHLPMARRNTLREQG	PTPN14	661	Q15678
VRGHQGLRDQKRMRL	FTSJ3	481	Q8IY81
NRQPMEGRSRDGGLR	POLR2B	1071	P30876
RGLQEHQRGRTLTMV	MPV17	41	P39210
IAPSRGMRIGVQIHN	PKHD1	461	P08F94
LGHSMNPRARKNRSR	SPDYE2B	291	A6NHP3
MVQRPQPHRNRAGLD	TRAF3IP2	186	O43734
LGAQLSPARRRQHMQ	CLCN2	636	P51788
RPGHKRFRTQMSNLQ	ZFHX4	2881	Q86UP3
AGVMQNPRHLVRRRG	TRBV18	21	A0A087X0M5
LPGGNSRMTQERLER	MINDY4	331	Q4G0A6
MKNHSLRAGRECPRG	SPATA31A1	76	Q5TZJ5
GHRMNIERALRQLDG	SHANK3	1716	Q9BYB0
LGHSMNPRARKNRSR	SPDYE2	291	Q495Y8
LGHSMNPRARKNRSR	SPDYE6	291	P0CI01
PGRNTTQRHRLDIQM	SEMA6A	46	Q9H2E6
RGRRQRRMHPNVSQG	RSPO3	26	Q9BXY4
RMGRFHRILEPGLNI	STOML2	51	Q9UJZ1
LKDGRHPQGEQMYRR	PLEC	596	Q15149
MVGLHNLEPRGERNI	PRAG1	161	Q86YV5
RAMGRNPHQGRRNQE	ZNFX1	71	Q9P2E3
DRHMNKHLRGGRQPF	ZNF469	3406	Q96JG9
GSLRRHMGIHNDLRP	ZNF236	726	Q9UL36
RIHRRGNMNVIDVGR	ZNF12	681	P17014
QARHLVEQRRGSPME	VWA7	336	Q9Y334
LNTLNVPGCHREMRR	HIVEP1	1351	P15822
MRRSVLVRNPGHKGL	ZNF358	1	Q9NW07
RRSRQHEQLPGQRHM	nan	6	Q9UFV3
LNRHIRGHMGIRPFQ	ZBTB6	341	Q15916
MSRQLTHFPRGERLG	KRT72	1	Q14CN4
LAQREHRSRMPKTGL	N4BP2	891	Q86UW6
MATRGHVQDPNDRRL	NAA25	1	Q14CX7