Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of postsynaptic actin cytoskeleton

POTEF ACTB ACTG1 POTEKP POTEE POTEI

1.60e-11111176GO:0098973
GeneOntologyMolecularFunctionstructural constituent of postsynapse

POTEF ACTB ACTG1 POTEKP POTEE POTEI

2.85e-08321176GO:0099186
GeneOntologyMolecularFunctionstructural constituent of synapse

POTEF ACTB ACTG1 POTEKP POTEE POTEI

1.57e-07421176GO:0098918
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

CYLC2 POTEF ACTB ACTG1 POTEKP POTEE POTEI

1.15e-051301177GO:0005200
GeneOntologyMolecularFunction3'-5'-RNA exonuclease activity

EXOSC10 DIS3L HELZ2 CNOT1

6.37e-05371174GO:0000175
GeneOntologyMolecularFunctionRNA exonuclease activity, producing 5'-phosphomonoesters

EXOSC10 DIS3L HELZ2 CNOT1

8.69e-05401174GO:0016896
GeneOntologyMolecularFunctionexoribonuclease II activity

DIS3L HELZ2

1.02e-0431172GO:0008859
GeneOntologyMolecularFunctionRNA exonuclease activity

EXOSC10 DIS3L HELZ2 CNOT1

1.39e-04451174GO:0004532
GeneOntologyMolecularFunctioncatalytic activity, acting on RNA

EXOSC10 DIS3L GATC FARSB DICER1 GGT2P GGT3P FARS2 HELZ2 CNOT1

1.73e-0441711710GO:0140098
GeneOntologyMolecularFunctionphenylalanine-tRNA ligase activity

FARSB FARS2

2.03e-0441172GO:0004826
GeneOntologyMolecularFunction[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity

PDP1 PDP2

3.37e-0451172GO:0004741
GeneOntologyMolecularFunctioncatalytic activity, acting on a nucleic acid

EXOSC10 DIS3L GATC FARSB REV3L RFC1 DICER1 GGT2P GGT3P FARS2 HELZ2 CNOT1

4.06e-0464511712GO:0140640
GeneOntologyMolecularFunction3'-5' exonuclease activity

EXOSC10 DIS3L HELZ2 CNOT1

4.52e-04611174GO:0008408
GeneOntologyMolecularFunctionexonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

EXOSC10 DIS3L HELZ2 CNOT1

4.81e-04621174GO:0016796
GeneOntologyMolecularFunctionpeptidyltransferase activity

GGT2P GGT3P

5.03e-0461172GO:0000048
GeneOntologyMolecularFunctionleukotriene-C(4) hydrolase

GGT2P GGT3P

5.03e-0461172GO:0002951
GeneOntologyMolecularFunction[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

HS3ST2 HS3ST1

7.01e-0471172GO:0008467
GeneOntologyMolecularFunctionuridylyltransferase activity

GALT UGP2

7.01e-0471172GO:0070569
GeneOntologyMolecularFunctionleukotriene C4 gamma-glutamyl transferase activity

GGT2P GGT3P

9.31e-0481172GO:0103068
GeneOntologyMolecularFunctionATP-dependent activity

ABCA3 ACTB RFC1 DNAH7 DICER1 CCT8L2 KIF3B HELZ2 MACF1 CCT8L1P DNAH11

9.69e-0461411711GO:0140657
GeneOntologyMolecularFunctionglutathione hydrolase activity

GGT2P GGT3P

1.19e-0391172GO:0036374
GeneOntologyMolecularFunctionRNA nuclease activity

EXOSC10 DIS3L DICER1 HELZ2 CNOT1

1.24e-031361175GO:0004540
GeneOntologyMolecularFunctioncatalytic activity, acting on a tRNA

GATC FARSB GGT2P GGT3P FARS2

1.60e-031441175GO:0140101
GeneOntologyMolecularFunctiontranscription coactivator activity

MAGED1 MED14 TRRAP ZMIZ2 DYRK1B HELZ2 RERE

2.07e-033031177GO:0003713
GeneOntologyMolecularFunctionexonuclease activity

EXOSC10 DIS3L HELZ2 CNOT1

2.10e-03921174GO:0004527
GeneOntologyMolecularFunctionprofilin binding

ACTG1 FMNL1

2.55e-03131172GO:0005522
GeneOntologyBiologicalProcesspostsynaptic actin cytoskeleton organization

POTEF ACTB ACTG1 POTEKP POTEE POTEI

1.92e-08311176GO:0098974
GeneOntologyBiologicalProcesspostsynaptic cytoskeleton organization

POTEF ACTB ACTG1 POTEKP POTEE POTEI

4.15e-08351176GO:0099188
GeneOntologyBiologicalProcessregulation of synaptic vesicle endocytosis

ACTB LRRK2 ACTG1 NLGN1

3.54e-05331174GO:1900242
GeneOntologyBiologicalProcesspostsynapse organization

POTEF ACTB LRRK2 ACTG1 POTEKP NLGN1 POTEE IGF1R POTEI

7.49e-053131179GO:0099173
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

POTEF FAT3 ACTB LRRK2 ACTG1 POTEKP NLGN1 PTCH1 BTBD3 POTEE IGF1R MACF1 RERE POTEI

8.76e-0574811714GO:0048667
GeneOntologyBiologicalProcessregulation of synaptic vesicle recycling

ACTB LRRK2 ACTG1 NLGN1

1.12e-04441174GO:1903421
GeneOntologyBiologicalProcesscell morphogenesis

RHOJ POTEF FAT3 ACTB LRRK2 ACTG1 POTEKP NLGN1 PTCH1 DICER1 BTBD3 POTEE FRY IGF1R MACF1 RERE POTEI FMNL1

1.33e-04119411718GO:0000902
GeneOntologyBiologicalProcessneuron projection morphogenesis

POTEF ACTB LRRK2 ACTG1 POTEKP NLGN1 PTCH1 DICER1 BTBD3 POTEE IGF1R MACF1 RERE POTEI

1.81e-0480211714GO:0048812
GeneOntologyBiologicalProcessregulation of transepithelial transport

ACTB ACTG1

1.90e-0441172GO:0150111
GeneOntologyBiologicalProcessphenylalanyl-tRNA aminoacylation

FARSB FARS2

1.90e-0441172GO:0006432
GeneOntologyBiologicalProcesssynaptic vesicle endocytosis

ACTB LRRK2 ACTG1 NLGN1 SLC2A4

2.18e-04961175GO:0048488
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

POTEF ACTB LRRK2 ACTG1 POTEKP NLGN1 PTCH1 DICER1 BTBD3 POTEE IGF1R MACF1 RERE POTEI

2.25e-0481911714GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

POTEF ACTB LRRK2 ACTG1 POTEKP NLGN1 PTCH1 DICER1 BTBD3 POTEE IGF1R MACF1 RERE POTEI

2.45e-0482611714GO:0048858
GeneOntologyCellularComponentNuA4 histone acetyltransferase complex

POTEF ACTB ACTG1 POTEKP TRRAP POTEE POTEI

4.57e-10321187GO:0035267
GeneOntologyCellularComponentH4/H2A histone acetyltransferase complex

POTEF ACTB ACTG1 POTEKP TRRAP POTEE POTEI

4.57e-10321187GO:0043189
GeneOntologyCellularComponentH4 histone acetyltransferase complex

POTEF ACTB ACTG1 POTEKP TRRAP POTEE POTEI

5.80e-09451187GO:1902562
GeneOntologyCellularComponenthistone acetyltransferase complex

POTEF ACTB ACTG1 POTEKP TRRAP POTEE POTEI

1.04e-06941187GO:0000123
GeneOntologyCellularComponentprotein acetyltransferase complex

POTEF ACTB ACTG1 POTEKP TRRAP POTEE POTEI

2.06e-061041187GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

POTEF ACTB ACTG1 POTEKP TRRAP POTEE POTEI

2.83e-061091187GO:1902493
GeneOntologyCellularComponentintracellular protein-containing complex

ZSWIM5 POTEF ACTB GATC ACTG1 FAM98A POTEKP PATL1 REV3L TRRAP DICER1 POTEE CCT8L2 PDRG1 LMO7 POTEI CCT8L1P CNOT1

8.53e-0697211818GO:0140535
GeneOntologyCellularComponentactin filament

POTEF ACTB ACTG1 POTEKP POTEE POTEI

1.82e-041461186GO:0005884
GeneOntologyCellularComponentaxon

ABR POTEF LRFN3 ACTB LRRK2 ACTG1 POTEKP PTCH1 DICER1 PTPN5 POTEE IGF1R KIF3B POTEI

5.02e-0489111814GO:0030424
GeneOntologyCellularComponentdense body

ACTB ACTG1

6.51e-0471182GO:0097433
GeneOntologyCellularComponentintraciliary transport particle A

IFT140 TTC21B

8.65e-0481182GO:0030991
GeneOntologyCellularComponentblood microparticle

POTEF ACTB ACTG1 ACTG2 POTEE

1.36e-031441185GO:0072562
GeneOntologyCellularComponentalveolar lamellar body

ABCA3 SFTPB

1.38e-03101182GO:0097208
GeneOntologyCellularComponentmultivesicular body

ABCA3 SFTPB LRRK2 SLC2A4

1.56e-03881184GO:0005771
GeneOntologyCellularComponentchaperonin-containing T-complex

CCT8L2 CCT8L1P

1.68e-03111182GO:0005832
GeneOntologyCellularComponentprotein folding chaperone complex

CCT8L2 PDRG1 CCT8L1P

1.71e-03421183GO:0101031
DomainActin_CS

POTEF ACTB ACTG1 ACTG2 POTEE POTEI

3.45e-10161146IPR004001
DomainACTINS_2

POTEF ACTB ACTG1 ACTG2 POTEE POTEI

5.31e-10171146PS00432
DomainActin/actin-like_CS

POTEF ACTB ACTG1 ACTG2 POTEE POTEI

7.92e-10181146IPR020902
DomainACTINS_ACT_LIKE

POTEF ACTB ACTG1 ACTG2 POTEE POTEI

1.15e-09191146PS01132
DomainActin

POTEF ACTB ACTG1 ACTG2 POTEE POTEI

2.94e-08311146IPR004000
DomainActin

POTEF ACTB ACTG1 ACTG2 POTEE POTEI

2.94e-08311146PF00022
DomainACTIN

POTEF ACTB ACTG1 ACTG2 POTEE POTEI

2.94e-08311146SM00268
DomainACTINS_1

ACTB ACTG1 ACTG2

1.21e-0581143PS00406
DomainCOR

LRRK2 LRRK1

3.69e-0521142IPR032171
DomainCOR

LRRK2 LRRK1

3.69e-0521142PF16095
DomainRNase_II/R_CS

DIS3L HELZ2

2.20e-0441142IPR022966
DomainROC_dom

LRRK2 LRRK1

2.20e-0441142IPR020859
DomainROC

LRRK2 LRRK1

2.20e-0441142PS51424
DomainARM-type_fold

MROH2A LRRK2 TRRAP EFR3A SF3B1 UPF2 HECTD1 FMNL1 XPOT

2.34e-043391149IPR016024
DomainPHR

BTBD6 BTBD3

3.65e-0451142IPR012983
DomainPHR

BTBD6 BTBD3

3.65e-0451142PF08005
Domain-

ABCA3 NWD1 RHOJ LRRK2 LRRK1 RFC1 DNAH7 DICER1 AK7 HELZ2 HS3ST2 HS3ST1 DNAH11

6.26e-04746114133.40.50.300
DomainP-loop_NTPase

ABCA3 NWD1 RHOJ LRRK2 LRRK1 RFC1 DNAH7 DICER1 AK7 KIF3B HELZ2 HS3ST2 HS3ST1 DNAH11

6.55e-0484811414IPR027417
DomainARM-like

MROH2A LRRK2 TRRAP EFR3A SF3B1 HECTD1 XPOT

1.35e-032701147IPR011989
DomainKinase-like_dom

LRRK2 LRRK1 TRRAP MAP3K6 TYK2 NEK4 IGF1R DSTYK DYRK1B MACF1

1.79e-0354211410IPR011009
DomainAAA

ABCA3 RFC1 DNAH7 HELZ2 DNAH11

1.90e-031441145SM00382
DomainAAA+_ATPase

ABCA3 RFC1 DNAH7 HELZ2 DNAH11

1.90e-031441145IPR003593
DomainPP2C_BS

PDP1 PDP2

2.34e-03121142IPR000222
Domain-

LRRK2 TRRAP EFR3A SF3B1 HECTD1 XPOT

2.42e-0322211461.25.10.10
DomainMIRO-like

LRRK2 LRRK1

2.76e-03131142IPR013684
DomainRoc

LRRK2 LRRK1

2.76e-03131142PF08477
DomainDynein_heavy_chain_D4_dom

DNAH7 DNAH11

3.20e-03141142IPR024317
DomainPP2C_SIG

PDP1 PDP2

3.20e-03141142SM00331
DomainDynein_HC_stalk

DNAH7 DNAH11

3.20e-03141142IPR024743
DomainDynein_heavy_dom-2

DNAH7 DNAH11

3.20e-03141142IPR013602
DomainDHC_N2

DNAH7 DNAH11

3.20e-03141142PF08393
DomainMT

DNAH7 DNAH11

3.20e-03141142PF12777
DomainAAA_8

DNAH7 DNAH11

3.20e-03141142PF12780
DomainDHC_fam

DNAH7 DNAH11

3.68e-03151142IPR026983
DomainDynein_heavy

DNAH7 DNAH11

3.68e-03151142PF03028
DomainDynein_heavy_dom

DNAH7 DNAH11

3.68e-03151142IPR004273
DomainPPM_1

PDP1 PDP2

3.68e-03151142PS01032
DomainL_dom-like

LRFN3 LRRK2 LRRK1 IGF1R XRRA1 LRRC73 RABGGTA

4.01e-033281147IPR032675
Domain-

POTEF LRRK2 LRRK1 POTEE POTEI HECTD1

4.17e-0324811461.25.40.20
DomainAnkyrin_rpt-contain_dom

POTEF LRRK2 LRRK1 POTEE POTEI HECTD1

4.69e-032541146IPR020683
DomainPP2C

PDP1 PDP2

4.73e-03171142IPR015655
DomainAnkyrin_rpt

POTEF LRRK2 LRRK1 POTEE POTEI HECTD1

5.44e-032621146IPR002110
DomainBACK

BTBD6 BTBD3 BTBD7

5.89e-03601143SM00875
DomainPP2C

PDP1 PDP2

5.90e-03191142PF00481
Pubmed

Identification of a novel actin isoform in hepatocellular carcinoma.

POTEF ACTB ACTG1 ACTG2 POTEKP POTEE POTEI

2.89e-1415119716824795
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

POTEF ACTB LRRK2 MED14 ACTG1 ACTG2 POTEKP NEK4 POTEE SF3B1 SLC25A13 TTC21B OSMR HECTD1 RABGGTA

2.82e-105131191525798074
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

EXOSC10 POTEF ACTB ACTG1 ACTG2 POTEKP RFC1 POTEE GTF2I SF3B1 POTEI

2.63e-092711191132433965
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

POTEF ACTB ACTG1 POTEKP LRPPRC SF3B1 UPF2 HS3ST1 CNOT1

3.51e-08202119924639526
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

DOCK4 POTEF FAM98A MAP3K6 DNAH7 NEK4 FSIP2 LRPPRC IGF1R LMO7 DSTYK SYNE2 DYRK1B MACF1 HECTD1 DOP1B

4.34e-088611191636931259
Pubmed

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.

ABCA3 ZSWIM5 POTEF ACTB LRRK2 POTEE POTEI CNOT1

4.93e-08149119822664934
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

EXOSC10 RFC1 TRRAP DICER1 LRPPRC GTF2I SF3B1 SLC25A13 SYNE2 HELZ2 MACF1 HECTD1 CNOT1 XPOT

5.70e-086531191422586326
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ICE1 DNAH7 DICER1 BTBD3 SYNE2 CNOT1 DOP1B

6.48e-08102119710231032
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

POTEF ACTB ACTG1 FARSB ACTG2 BUD13 FAM98A POTEKP DNAH7 AK7 POTEE LRPPRC GTF2I SF3B1 SLC25A13 PDP2 MACF1 POTEI

8.04e-0811531191829845934
Pubmed

Actin associates with the nucleocapsid domain of the human immunodeficiency virus Gag polyprotein.

ACTB ACTG1 ACTG2

7.75e-07611939971772
Pubmed

Interaction of the human immunodeficiency virus type 1 nucleocapsid with actin.

ACTB ACTG1 ACTG2

7.75e-076119310074138
Pubmed

Virus assembly and plasma membrane domains: which came first?

ACTB ACTG1 ACTG2

7.75e-076119322989508
Pubmed

HIV-1 protease cleaves actin during acute infection of human T-lymphocytes.

ACTB ACTG1 ACTG2

7.75e-07611931540415
Pubmed

Mammalian CAP interacts with CAP, CAP2, and actin.

ACTB ACTG1 SERPINB8

7.75e-07611938761950
Pubmed

HIV type 1 Gag and nucleocapsid proteins: cytoskeletal localization and effects on cell motility.

ACTB ACTG1 ACTG2

7.75e-076119311709093
Pubmed

Tagging the human immunodeficiency virus gag protein with green fluorescent protein. Minimal evidence for colocalisation with actin.

ACTB ACTG1 ACTG2

7.75e-076119310049817
Pubmed

Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutants.

ACTB ACTG1 ACTG2

7.75e-076119312009869
Pubmed

HIV-1 Tat protein variants: critical role for the cysteine region in synaptodendritic injury.

ACTB ACTG1 ACTG2

7.75e-076119323811015
Pubmed

Retroviral assembly and budding occur through an actin-driven mechanism.

ACTB ACTG1 ACTG2

7.75e-076119319883584
Pubmed

Dynamic imaging of cell-free and cell-associated viral capture in mature dendritic cells.

ACTB ACTG1 ACTG2

7.75e-076119321917091
Pubmed

HIV-1 Gag protein associates with F-actin present in microfilaments.

ACTB ACTG1 ACTG2

7.75e-07611938661406
Pubmed

A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.

ACTB ACTG1 ACTG2

7.75e-076119323017337
Pubmed

Synaptodendritic recovery following HIV Tat exposure: neurorestoration by phytoestrogens.

ACTB ACTG1 ACTG2

7.75e-076119323875777
Pubmed

Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton.

ACTB ACTG1 ACTG2

7.75e-07611939841925
Pubmed

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.

POTEF ACTB ACTG1 ACTG2 POTEE POTEI

1.02e-0696119623580065
Pubmed

The PDZ-adaptor protein syntenin-1 regulates HIV-1 entry.

ACTB ACTG1 ACTG2

1.35e-067119322535526
Pubmed

Selective targeting of ITK blocks multiple steps of HIV replication.

ACTB ACTG1 ACTG2

1.35e-067119318443296
Pubmed

The trinity of the cortical actin in the initiation of HIV-1 infection.

ACTB ACTG1 ACTG2

1.35e-067119322640593
Pubmed

HIV-1 replication from after cell entry to the nuclear periphery.

ACTB ACTG1 ACTG2

1.35e-067119317504171
Pubmed

siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat.

ACTB ACTG1 ACTG2

1.35e-067119322465675
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

CYLC2 ZSWIM5 POTEF ACTB ACTG1 ACTG2 FAM98A RYR2 POTEE LRPPRC SF3B1 LMO7 SLC25A13 SYNE2 UGP2 MACF1 CFAP74 POTEI

2.05e-0614421191835575683
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

EXOSC10 MED14 FARSB BUD13 FAM98A RFC1 TRRAP UPF2 SLC25A13 NEMF MACF1 HECTD1 CNOT1

2.15e-067591191335915203
Pubmed

Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production.

ACTB ACTG1 ACTG2

2.16e-068119314694110
Pubmed

Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.

ACTB ACTG1 ACTG2

2.16e-068119320147394
Pubmed

Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization.

ACTB ACTG1 ACTG2

2.16e-068119323260110
Pubmed

Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF.

ACTB ACTG1 ACTG2

3.23e-069119310556093
Pubmed

Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.

POTEKP POTEE POTEI

3.23e-069119316364570
Pubmed

Cytoskeletal proteins inside human immunodeficiency virus type 1 virions.

ACTB ACTG1 ACTG2

3.23e-06911938892894
Pubmed

HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells.

ACTB ACTG1 ACTG2

3.23e-069119318775311
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

SLC25A42 FAM98A PATL1 RFC1 DICER1 RYR2 FRY KIF3B CNOT1 GABRA1

4.55e-064621191031138677
Pubmed

Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus.

ACTB ACTG1 ACTG2

4.61e-061011931907279
Pubmed

Non-viral cellular substrates for human immunodeficiency virus type 1 protease.

ACTB ACTG1 ACTG2

4.61e-061011931991513
Pubmed

Gelsolin activity controls efficient early HIV-1 infection.

ACTB ACTG1 ACTG2

4.61e-0610119323575248
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

ACTB HLCS PTPN5 LRPPRC GTF2I SF3B1 PDRG1 SLC25A13 POTEI DOP1B XPOT

4.68e-065731191128330616
Pubmed

A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.

ACTB ACTG1 ACTG2 TRRAP

6.28e-0635119420946988
Pubmed

CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function.

ACTB ACTG1 ACTG2

6.32e-0611119330962377
Pubmed

N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeleton.

ACTB ACTG1 ACTG2

6.32e-0611119323294842
Pubmed

Quantitative proteomic analysis of lentiviral vectors using 2-DE.

ACTB ACTG1 ACTG2

6.32e-0611119319639585
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

IFT140 DIS3L FAT3 HLCS BUD13 REV3L TRRAP DICER1 TYK2 GFOD1 SLC25A13 MACF1 RERE KDM1B OSMR

6.59e-0611161191531753913
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

EXOSC10 ACTB ACTG1 FARSB FAM98A PATL1 RFC1 LRPPRC GTF2I SF3B1 PDRG1 SLC25A13 SYNE2 NEMF MACF1 HECTD1 XPOT

6.72e-0614151191728515276
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

EXOSC10 ACTB FAM98A RFC1 TYK2 LRPPRC SF3B1 UPF2 SLC25A13 NEMF

7.08e-064861191030940648
Pubmed

Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.

EXOSC10 UPF2 PDP1

8.40e-0612119314527413
Pubmed

HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.

ACTB ACTG1 ACTG2

8.40e-0612119323071112
Pubmed

Lessons on conditional gene targeting in mouse adipose tissue.

DICER1 SLC2A4 IGF1R

8.40e-0612119323321074
Pubmed

Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.

IFT140 SFTPB PTCH1 DNAH11

1.08e-0540119432317081
Pubmed

Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high-fat diet-induced obesity and insulin resistance in mice.

DICER1 SLC2A4 IGF1R

1.09e-0513119323349485
Pubmed

Beta- and gamma-cytoplasmic actins are required for meiosis in mouse oocytes.

ACTB ACTG1

1.16e-052119221778137
Pubmed

De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.

ACTB ACTG1

1.16e-052119222366783
Pubmed

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.

LRRK2 LRRK1

1.16e-052119218272292
Pubmed

Prenatal presentation and diagnosis of Baraitser-Winter syndrome using exome sequencing.

ACTB ACTG1

1.16e-052119232588558
Pubmed

Baraitser-Winter cerebrofrontofacial syndrome.

ACTB ACTG1

1.16e-052119227625340
Pubmed

Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice.

LRRK2 LRRK1

1.16e-052119235534227
Pubmed

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

LRRK2 LRRK1

1.16e-052119217394548
Pubmed

A primate-specific POTE-actin fusion protein plays a role in apoptosis.

POTEF POTEE

1.16e-052119219669888
Pubmed

Isolation of cDNA clones for mouse cytoskeletal gamma-actin and differential expression of cytoskeletal actin mRNAs in mouse cells.

ACTB ACTG1

1.16e-05211923221869
Pubmed

ABCA3 is critical for lamellar body biogenesis in vivo.

ABCA3 SFTPB

1.16e-052119217540762
Pubmed

Human leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions?

LRRK2 LRRK1

1.16e-052119222988872
Pubmed

Identification and developmental expression of a smooth-muscle gamma-actin in postmeiotic male germ cells of mice.

ACTG1 ACTG2

1.16e-05211922747639
Pubmed

Genetic Analysis of LRRK1 and LRRK2 Variants in Essential Tremor Patients.

LRRK2 LRRK1

1.16e-052119229812962
Pubmed

Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension.

ACTB ACTG1

1.16e-052119221502360
Pubmed

Dynamic and redundant regulation of LRRK2 and LRRK1 expression.

LRRK2 LRRK1

1.16e-052119218045479
Pubmed

Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease.

LRRK2 LRRK1

1.16e-052119220144646
Pubmed

The evolution and complexity of the genes encoding the cytoskeletal proteins of human epidermal cells.

ACTB ACTG1

1.16e-05211926686106
Pubmed

Actin amino-acid sequences. Comparison of actins from calf thymus, bovine brain, and SV40-transformed mouse 3T3 cells with rabbit skeletal muscle actin.

ACTB ACTG1

1.16e-0521192213279
Pubmed

The First Korean Case of Baraitser-Winter Cerebro-Fronto-Facial Syndrome with a Novel Mutation in ACTB Diagnosed Via Targeted Gene Panel Sequencing and Literature Review.

ACTB ACTG1

1.16e-052119233334799
Pubmed

Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease.

LRRK2 LRRK1

1.16e-052119217225181
Pubmed

Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway.

LRRK2 LRRK1

1.16e-052119217324517
Pubmed

β-Actin specifically controls cell growth, migration, and the G-actin pool.

ACTB ACTG1

1.16e-052119221900491
Pubmed

MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development.

PTCH1 DICER1

1.16e-052119226773048
Pubmed

Beta and gamma-cytoplasmic actins display distinct distribution and functional diversity.

ACTB ACTG1

1.16e-052119219638415
Pubmed

Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177.

ACTB ACTG1

1.16e-05211923335520
Pubmed

Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.

ACTB ACTG1

1.16e-05211929288906
Pubmed

High level expression of transfected beta- and gamma-actin genes differentially impacts on myoblast cytoarchitecture.

ACTB ACTG1

1.16e-05211921577857
Pubmed

Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation.

PDP1 PDP2

1.16e-05211929651365
Pubmed

Delayed embryonic development and impaired cell growth and survival in Actg1 null mice.

SFTPB ACTG1

1.16e-052119220662086
Pubmed

Baraitser-Winter Cerebrofrontofacial Syndrome

ACTB ACTG1

1.16e-052119226583190
Pubmed

Knockout of ACTB and ACTG1 with CRISPR/Cas9(D10A) Technique Shows that Non-Muscle β and γ Actin Are Not Equal in Relation to Human Melanoma Cells' Motility and Focal Adhesion Formation.

ACTB ACTG1

1.16e-052119232326615
Pubmed

Severe forms of Baraitser-Winter syndrome are caused by ACTB mutations rather than ACTG1 mutations.

ACTB ACTG1

1.16e-052119223756437
Pubmed

Cytochalasin D-induced actin gene expression in murine erythroleukemia cells.

ACTB ACTG1

1.16e-05211928482333
Pubmed

LRRK2 Inhibition Ameliorates Dexamethasone-Induced Glucose Intolerance via Prevents Impairment in GLUT4 Membrane Translocation in Adipocytes.

LRRK2 SLC2A4

1.16e-052119233132310
Pubmed

Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms.

ACTB ACTG1

1.16e-052119229265728
Pubmed

Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia.

ACTB ACTG1

1.16e-052119222246323
Pubmed

Crystallization and preliminary crystallographic studies of the catalytic subunits of human pyruvate dehydrogenase phosphatase isoforms 1 and 2.

PDP1 PDP2

1.16e-052119220208177
Pubmed

Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes.

ACTB ACTG1

1.16e-05211922837653
Pubmed

Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma: A Functional Assessment Based on Actin Three-Dimensional Structures.

ACTB ACTG1

1.16e-052119232349449
Pubmed

Baraitser-Winter cerebrofrontofacial syndrome: Report of two adult siblings.

ACTB ACTG1

1.16e-052119232506774
Pubmed

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.

LRRK2 LRRK1

1.16e-052119233459343
Pubmed

Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation.

ACTB ACTG1

1.16e-052119220847274
Pubmed

LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes.

LRRK2 SLC2A4

1.16e-052119237845194
Pubmed

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.

LRRK2 LRRK1

1.16e-052119229056298
InteractionACTG2 interactions

POTEF ACTB LRRK2 ACTG1 ACTG2 NEK4 POTEE POTEI

4.01e-10491188int:ACTG2
InteractionDUSP15 interactions

GALT HLCS DICER1 PTPN5 LRPPRC IGF1R GTF2I

1.16e-09351187int:DUSP15
InteractionNEK4 interactions

POTEF ACTB LRRK2 MED14 ACTG1 ACTG2 POTEKP NEK4 POTEE SF3B1 SLC25A13 TTC21B OSMR HECTD1 RABGGTA

1.58e-0658211815int:NEK4
InteractionLGR4 interactions

RHOJ POTEF ACTB ACTG1 POTEKP LRPPRC SF3B1 UPF2 HS3ST1 CNOT1

3.30e-0626211810int:LGR4
InteractionPOTEJ interactions

ACTB ACTG1 ACTG2 POTEE POTEI

1.32e-05521185int:POTEJ
InteractionSCIN interactions

POTEF ACTB ACTG1 NEK4 POTEI

2.26e-05581185int:SCIN
InteractionDUSP26 interactions

DICER1 NEK4 LRPPRC IGF1R XPOT

2.46e-05591185int:DUSP26
InteractionSIRT7 interactions

EXOSC10 MAGED1 RFC1 TRRAP DICER1 LRPPRC GTF2I SF3B1 SLC25A13 SYNE2 HELZ2 MACF1 HECTD1 CNOT1 XPOT

2.96e-0574411815int:SIRT7
InteractionADARB1 interactions

EXOSC10 POTEF ACTB ACTG1 ACTG2 BUD13 POTEKP RFC1 LRPPRC GTF2I SF3B1 POTEI

3.03e-0548911812int:ADARB1
InteractionERRFI1 interactions

POTEF ACTB ACTG1 ACTG2 POTEKP POTEE

3.96e-051071186int:ERRFI1
InteractionACTA2 interactions

POTEF ACTB LRRK2 ACTG1 ACTG2 POTEKP MAP3K6 NEK4 POTEE POTEI

4.58e-0535511810int:ACTA2
Cytoband2q21.1

POTEF POTEKP POTEE POTEI

1.63e-055811942q21.1
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEF POTEKP POTEE POTEI

2.11e-0713774685
GeneFamilyActins

ACTB ACTG1 ACTG2

1.47e-066773929
GeneFamilyExosome complex

EXOSC10 DIS3L

1.15e-0312772817
GeneFamilyCD molecules|Gamma-glutamyltransferases

GGT2P GGT3P

1.35e-0313772564
GeneFamilyDyneins, axonemal

DNAH7 DNAH11

2.34e-0317772536
GeneFamilyProtein phosphatases, Mg2+/Mn2+ dependent

PDP1 PDP2

2.34e-0317772701
GeneFamilyAminoacyl tRNA synthetases, Class II

FARSB FARS2

2.92e-0319772132
GeneFamilyIntraflagellar transport proteins|Tetratricopeptide repeat domain containing

IFT140 TTC21B

4.65e-0324772615
GeneFamilyFibronectin type III domain containing

COL12A1 LRFN3 IGF1R OSMR

4.84e-03160774555
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

DOCK4 REV3L TRRAP DICER1 EFR3A NEK4 LRPPRC IGF1R UPF2 FARS2 SLC25A13 SYNE2 MACF1 OSMR DOP1B

7.98e-0685611915M4500
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN

EXOSC10 SLC25A42 ABR GALT ORC6 FARSB TRRAP DICER1 TYK2 SF3B1 GFOD1 ZMIZ2 HELZ2 D2HGDH DOP1B

1.54e-0590511915M40865
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ITGA11 RHOJ ACTB ACTG2 PTCH1 SLC2A4 UGP2

6.26e-071831197e84539978ab4de42e19186aed00f24bb50cbc21f
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

SFTPB DNAH7 LMO7 SYNE2 MACF1 OSMR DNAH11

9.92e-071961197af4cdc61830685a888a1209826c23bcf54a43084
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

SFTPB DNAH7 LMO7 SYNE2 MACF1 OSMR DNAH11

9.92e-0719611976d02d494196e3f857d53eea46d9419690d43beca
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 SFTPB LRRK2 NLGN1 LMO7 SYNE2

1.20e-0612711965b0adbcafad31a6759c9bdce2f7f9591a8edc450
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NWD1 FRMPD2 DNAH7 AK7 LRRC73 DNAH11

2.92e-061481196d61123f0c811287843d066b932b4a9ff09c07c5b
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NWD1 FRMPD2 DNAH7 AK7 LRRC73 DNAH11

2.92e-061481196c8e93b87212f55774223caa385859c566fa1981f
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 ZSWIM5 PTCH1 RYR2 SERPINB8 HSD17B1

5.47e-0616511966d315e0734079ad05336cc2c3f24d870c9105bc8
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocyte_monocyte_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL12A1 ZSWIM5 PTCH1 RYR2 SERPINB8 HSD17B1

5.47e-06165119684f5597b1bb75f42de9a224196bb8ac198bbe3bf
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)|367C / Donor, Lineage, Cell class and subclass (all cells)

ABCA3 SFTPB LRRK2 GGT2P LMO7 OSBP2

6.07e-061681196e20e1936573fdde78426d7a4eb45c458d5c4dbb4
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)-|367C / Donor, Lineage, Cell class and subclass (all cells)

ABCA3 SFTPB LRRK2 GGT2P LMO7 OSBP2

6.07e-06168119616b517e3159ad6e6d25fd48f7d5f46e77b2b318d
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

8.45e-061781196de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 SFTPB LRRK2 NLGN1 LMO7 SYNE2

8.72e-061791196fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

9.59e-061821196fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.02e-0518411965daff849625f2f41d56615569c0ed59cd733b34c
ToppCellNS-moderate-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.05e-0518511965e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.05e-05185119630f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.05e-0518511963e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.05e-05185119618a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellNS-critical-d_16-33-Epithelial-Ciliated|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.08e-05186119676033438426d8f9c72cd6691a7baf92104c9f03d
ToppCellNS-moderate-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.08e-05186119685787ff207f109ec7e3c0f729ba9bda739c2fdc9
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-1|TCGA-Breast / Sample_Type by Project: Shred V9

ABCA3 DIS3L ZSWIM5 NEK4 IGF1R KIF3B

1.12e-051871196a716b64ca03d9b61da765bf87f065ac9393303f1
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.12e-0518711969e10ed56090d82589bc457788282f664b70ace4b
ToppCell21-Trachea-Epithelial-Intermediate_ciliated|Trachea / Age, Tissue, Lineage and Cell class

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.12e-0518711961a2178a195d078d1963947b327c6d0d4f2f48341
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT3 ACTG2 PTCH1 SLC2A4 RYR2 HSD17B1

1.15e-0518811963177b2c1723268d330d3e9f24f9e24492ace6286
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.15e-05188119661a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.15e-05188119634b11f72ca73153d02edcd09b38983ad1a504659
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.15e-0518811962b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCell(7)_Epithelial-F_(Ciliated)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.15e-0518811969a8b9f745eed9f129b6c582f48fbbaaacbebb4b3
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FAT3 LRRK2 NLGN1 DNAH7 SYNE2 DNAH11

1.19e-051891196904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.19e-051891196b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.19e-05189119627329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellCOPD-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.19e-0518911963e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-0519111967b5da29109aa28768c67653a1bc0f385c2d2269b
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-0519111962a8e6d560907e71e9f6e190ca0667da804e25641
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-05191119646c9d4d10c66c0fae1fa351924091b69ea2f38d4
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-051911196fa9f8b50bfc7911c858bc2f9dcd204873d97ac61
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-051911196b4e335e798c9617356b8e24412f9270c42dce656
ToppCellBAL-Control-Epithelial-Epithelial-Ciliated|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-051911196c4b223b33c020a064f576711a3d700eb60a2d737
ToppCellMild_COVID-19-Epithelial-Ciliated|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-051911196995e76bbf07674d95b8ef09e078cf6410af27a09
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-051911196a37f20172b85566b9039254a89680e37fd503fd5
ToppCellBAL-Mild-Epithelial-Epithelial-Ciliated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-0519111962d36e08c5629cf73b6dd02cd173cafb52e8a3a7d
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-051911196e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-0519111969d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellwk_15-18-Epithelial-Proximal_epithelial-MUC16+_ciliated|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-051911196e81cd65dbf0ef1c2ab7088f73ce605d456dd3a7a
ToppCellControl-Epithelial-Ciliated|Control / Disease group,lineage and cell class (2021.01.30)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-051911196cdc08e95a0c8f5c7a8d01b6bbaafdb54ef2f0d12
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-0519111961c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellControl-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.34e-0519311960e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCellIPF-Epithelial-Ciliated|Epithelial / Disease state, Lineage and Cell class

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.34e-051931196ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCellControl-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

DOCK4 RHOJ FAT3 RYR2 GFOD1 MACF1

1.34e-0519311965896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA3 SFTPB LRRK2 DNAH7 AK7 DNAH11

1.34e-051931196bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

DOCK4 FAT3 NLGN1 PTCH1 MACF1 RERE

1.38e-051941196b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellNS-critical-d_07-13-Epithelial-Ciliated|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.38e-0519411961ae8a10e508e672e6677f0e3c986ac30d05adeb3
ToppCellCOVID-19-Epithelial-Ciliated_cells|COVID-19 / Condition, Lineage and Cell class

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.38e-05194119643be5fbd51dd58839cb03ca3ddd05a458e1ddb74
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

SFTPB DNAH7 AK7 LMO7 SYNE2 DNAH11

1.42e-051951196fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABR SLC25A13 GPCPD1 HS3ST2 HS3ST1 DOP1B

1.42e-0519511969d649ac7d2af313481069c95349efc0c68449e2b
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NWD1 DNAH7 AK7 KIF3B CFAP74 DNAH11

1.42e-05195119679dc031258579ea328181dda33710dd897f1064a
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

SFTPB DNAH7 AK7 LMO7 SYNE2 DNAH11

1.42e-051951196eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.42e-0519511963486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellmoderate-Epithelial-Ciliated|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.42e-051951196e80f5cdf0b18066b3e6c2f5452e58f101c67932c
ToppCellcritical-Epithelial-Ciliated|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.46e-05196119627b855c6e1ae44f16db998cf0e81bd686b9cee7e
ToppCellNS-moderate-d_0-4-Epithelial-Ciliated|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.50e-05197119671fea4aa6ce96c7693fa94792d08770622873850
ToppCellASK452-Epithelial-Transformed_epithelium|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

ABCA3 MAGED1 SFTPB LRRK2 RYR2 LMO7

1.50e-051971196b22a79a5922c865a360e2afc5506a08a512fa76a
ToppCellLV-09._Endothelium_I|LV / Chamber and Cluster_Paper

DOCK4 MAP3K6 PTPN5 GFOD1 SYNE2 OSMR

1.50e-051971196f9731d4d636e51b94a96805eee6afe9aedc175e3
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.55e-051981196ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ACTB ACTG2 NLGN1 SLC2A4 RYR2 DNAH11

1.55e-051981196c12e7511628db819a52959bb68580e27c00c2e41
ToppCellTracheal-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ABCA3 FAT3 ACTG2 SLC2A4 RYR2 OSBP2

1.55e-0519811961e1ea54f0c234f3b6d29064c4881d8a0c0949a75
ToppCellCOVID-19-lung|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK4 ABCA3 ABR SFTPB GPCPD1 FMNL1

1.59e-051991196155b03b859157013e9142e9248551369127d9204
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.64e-05200119652aef65f01b06cd98056f17977efe525aee6eb6f
ToppCellBronchial-10x5prime-Epithelial-Epi_airway_ciliated-Ciliated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.64e-05200119655c148238d5c80c1faa3428a917ae8075be2c145
ToppCellBronchial-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ITGA11 FAT3 ACTG2 SLC2A4 RYR2 FRY

1.64e-052001196a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.64e-0520011965abd6d81e1cc354484ae693fcd708d78926e75b5
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_ciliated-Ciliated|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NWD1 FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.64e-0520011969c9d2b0276c7b0709c2eeeb0673a2f58106fb14e
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NWD1 FRMPD2 AK7 LRRC73 DNAH11

5.35e-05151119581cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NWD1 FRMPD2 AK7 LRRC73 DNAH11

5.35e-0515111959cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NWD1 FRMPD2 DNAH7 AK7 DNAH11

5.87e-0515411954e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NWD1 FRMPD2 DNAH7 AK7 DNAH11

5.87e-0515411957556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NWD1 FRMPD2 DNAH7 AK7 DNAH11

6.06e-0515511955f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NWD1 FRMPD2 DNAH7 AK7 DNAH11

6.06e-0515511950944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA11 AK7 PTPN5 LMO7 DNAH11

6.83e-05159119500a157d033627d0e65c3fbd38d652c4cf56b47f6
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Ciliated_2|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

FRMPD2 DNAH7 CFAP74 LRRC73 DNAH11

8.14e-051651195731147b4337fd0de4383dc8170b4f9ccd98caec6
ToppCellTuft-tuft-1|World / Class top

GALNT10 DIS3L MED14 FAM98A GPCPD1

8.86e-0516811958ddc2ec483ed2c6c0fb2ae521c6861ceb6d32e34
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MROH2A FAT3 NLGN1 RYR2 DNAH11

9.11e-05169119512bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFT140 SLC25A42 FAT3 SLC2A4 SUOX

9.37e-051701195b180ec9a1b79025a180c8559c27c31272410dea8
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFT140 SLC25A42 FAT3 SLC2A4 SUOX

9.37e-05170119537c647f67505aa1ff12a198df1eeddd9f406fe15
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ITGA11 COL12A1 RHOJ FRMPD2 HS3ST2

9.90e-05172119541ddfb316429efef5f3fa0b0621ced383d9206f0
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

ABCA3 SFTPB LRRK2 LMO7 OSBP2

1.13e-041771195ac8f774596068e66c0a9ea8a318be0ce5f5df834
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

ABCA3 SFTPB LRRK2 LMO7 OSBP2

1.13e-041771195d9c4a93b0e04a13bf39992dd1c1ec8df2c5f89fe
ToppCellCiliated_cells-A-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

NWD1 FRMPD2 DNAH7 CFAP74 HS3ST1

1.19e-0417911950e6c22de2e3fb0ff23b3301863cf4011c5c59dff
ToppCellCiliated_cells-A-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

NLGN1 AK7 NEK4 HSD17B1 HS3ST1

1.19e-0417911951c41314b6fcfcac8d62034e7037570120d58f20f
ToppCellRSV-Healthy-0|RSV / Virus stimulation, Condition and Cluster

FMO4 ORC6 ACTB SYNE2 DYRK1B

1.22e-041801195974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCellControl-Fibroblasts-Airway_smooth_muscle|Control / group, cell type (main and fine annotations)

ITGA11 FAT3 ACTG2 NLGN1 RYR2

1.22e-041801195d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCellRSV-Healthy-0|Healthy / Virus stimulation, Condition and Cluster

FMO4 ORC6 ACTB SYNE2 DYRK1B

1.22e-041801195703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCellLPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ABCA3 SFTPB LRRK2 NLGN1 LMO7

1.26e-0418111950513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ABCA3 SFTPB FARSB LMO7 OSMR

1.26e-041811195576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FRMPD2 DNAH7 AK7 CFAP74 DNAH11

1.26e-041811195dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCellFrontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ACTG2 SLC2A4 BIK HSD17B1

1.28e-049611949e31d5ed093cf8ff49a315339c1b60d63b27666b
ToppCellFrontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ACTG2 SLC2A4 BIK HSD17B1

1.28e-04961194a1847fec63ba96c11c4074a78a8b3a45cf5b6d6f
ToppCellFrontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_1-MURAL_Mural.Rgs5Acta2.Cnn1_(Mural.Rgs5Acta2.Cnn1)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ACTG2 SLC2A4 BIK HSD17B1

1.28e-04961194e83a910187569d7c53d35cc094da1d166bf6f5b2
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

NWD1 FRMPD2 DNAH7 CFAP74 DNAH11

1.29e-0418211957ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MAGED1 AK7 ST6GALNAC2 LMO7 OSMR

1.32e-0418311956f8f997ffc9eaebca2683de125b6069d07c07d26
Drugtyrosinyl-5'-AMP

EXOSC10 CASP5 FARSB FARS2

2.50e-06191184CID000169008
DiseaseMoyamoya disease (implicated_via_orthology)

ACTB ACTG1 ACTG2 POTEKP

1.51e-0881154DOID:13099 (implicated_via_orthology)
Diseaseautosomal dominant nonsyndromic deafness 20 (implicated_via_orthology)

ACTB ACTG1 ACTG2 POTEKP

1.51e-0881154DOID:0110550 (implicated_via_orthology)
DiseaseBaraitser-Winter syndrome 1 (implicated_via_orthology)

ACTB ACTG1 ACTG2 POTEKP

1.51e-0881154DOID:0081112 (implicated_via_orthology)
Diseasethoracic aortic aneurysm (implicated_via_orthology)

ACTB ACTG1 ACTG2 POTEKP

1.51e-0881154DOID:14004 (implicated_via_orthology)
Diseaseintestinal atresia (implicated_via_orthology)

ACTB ACTG1 ACTG2 POTEKP

4.51e-08101154DOID:10486 (implicated_via_orthology)
Diseasepatent ductus arteriosus (implicated_via_orthology)

ACTB ACTG1 ACTG2 POTEKP

4.51e-08101154DOID:13832 (implicated_via_orthology)
DiseaseBaraitser-Winter syndrome

ACTB ACTG1

1.51e-0521152cv:C1853623
DiseaseIris Coloboma with Ptosis, Hypertelorism, and Mental Retardation

ACTB ACTG1

1.51e-0521152C1855722
DiseaseFryns-Aftimos Syndrome

ACTB ACTG1

1.51e-0521152C1853623
DiseaseHyaline Membrane Disease

ABCA3 SFTPB

4.51e-0531152C0020192
DiseaseRespiratory Distress Syndrome

ABCA3 SFTPB

4.51e-0531152C0852283
DiseaseHereditary pulmonary alveolar proteinosis

ABCA3 SFTPB

8.99e-0541152cv:C3711368
Diseasediacylglycerol 44:6 measurement

BUD13 SYNE2

1.49e-0451152EFO_0020070
Diseasechemokine (C-C motif) ligand 27 measurement

ITGA11 GALT NEK4 HS3ST2

1.65e-04701154EFO_0008082
DiseaseRespiratory Distress Syndrome, Newborn

ABCA3 SFTPB

2.24e-0461152C0035220
Diseasepulmonary alveolar proteinosis (is_implicated_in)

ABCA3 SFTPB

2.24e-0461152DOID:12120 (is_implicated_in)
Diseaseprimary ciliary dyskinesia (is_implicated_in)

DNAH7 CFAP74

2.24e-0461152DOID:9562 (is_implicated_in)
DiseaseUveoretinal Coloboma

ACTB ACTG1

3.12e-0471152C4554007
Diseaseaflatoxins-related hepatocellular carcinoma (biomarker_via_orthology)

GGT2P GGT3P

3.12e-0471152DOID:5022 (biomarker_via_orthology)
Diseasealcohol dependence (biomarker_via_orthology)

GGT2P GGT3P

4.15e-0481152DOID:0050741 (biomarker_via_orthology)
Diseaseholoprosencephaly (is_implicated_in)

PTCH1 CNOT1

4.15e-0481152DOID:4621 (is_implicated_in)
Diseaseoverall survival

BTBD3 OSMR

5.32e-0491152EFO_0000638
DiseaseCongenital ocular coloboma (disorder)

ACTB ACTG1

5.32e-0491152C0009363
DiseaseCongenital neurologic anomalies

ACTB ACTG1

6.64e-04101152C0497552
DiseaseCranioschisis

ACTB ACTG1

6.64e-04101152C0265541
DiseaseJeune thoracic dystrophy

IFT140 TTC21B

8.09e-04111152C0265275
Diseasemaleate measurement, Alpha ketoglutarate measurement, fumarate measurement

RHOJ EFR3A

8.09e-04111152EFO_0010457, EFO_0010480, EFO_0010509
DiseaseMalignant mesothelioma

COL12A1 RYR2 SF3B1 OSMR

8.89e-041091154C0345967
DiseaseShort Rib-Polydactyly Syndrome

IFT140 TTC21B

1.14e-03131152C0036996
DiseaseSaldino-Noonan Syndrome

IFT140 TTC21B

1.33e-03141152C0036069
DiseaseMajewski Syndrome

IFT140 TTC21B

1.33e-03141152C0024507
Diseaseamino acid measurement

ITGA11 BUD13 NLGN1 LRRK1 DNAH7 SLC2A4 RYR2 TYK2 NEK4

1.37e-036781159EFO_0005134
DiseaseDown syndrome (implicated_via_orthology)

DYRK1B DOP1B

1.53e-03151152DOID:14250 (implicated_via_orthology)
DiseaseRhabdomyosarcoma

PTCH1 DICER1

1.53e-03151152C0035412
Diseasebehavioural inhibitory control measurement

MROH2A EFR3A

1.74e-03161152EFO_0008467
Diseasecutaneous melanoma, hair color

LMO7 DSTYK SYNE2

1.84e-03621153EFO_0000389, EFO_0003924
DiseaseGlobal developmental delay

TRRAP IGF1R UGP2 CNOT1

1.85e-031331154C0557874
DiseaseIntellectual Disability

GALT FARSB PEX11B TRRAP FRY UGP2 MACF1

1.88e-034471157C3714756
Diseaselifestyle measurement

PTCH1 BTBD3 LRPPRC SUOX CFAP74

2.32e-032351155EFO_0010724
DiseaseC-reactive protein measurement

DOCK4 NUP210L GATC NLGN1 AK7 GTF2I UBP1 DSTYK ZMIZ2 MACF1 RERE DNAH11

2.64e-03120611512EFO_0004458
Diseasecognitive function measurement, self reported educational attainment

PTCH1 NEK4 LRPPRC SUOX ZMIZ2 TTC21B

2.73e-033551156EFO_0004784, EFO_0008354
DiseaseParoxysmal atrial fibrillation

IGF1R GTF2I SYNE2 KDM1B

3.30e-031561154C0235480
Diseasefamilial atrial fibrillation

IGF1R GTF2I SYNE2 KDM1B

3.30e-031561154C3468561
DiseasePersistent atrial fibrillation

IGF1R GTF2I SYNE2 KDM1B

3.30e-031561154C2585653
DiseaseLung diseases

SFTPB IGF1R DNAH11

3.55e-03781153C0024115
DiseaseAtrial Fibrillation

IGF1R GTF2I SYNE2 KDM1B

3.61e-031601154C0004238
DiseaseOvarian Serous Adenocarcinoma

LRRK2 TRRAP

3.61e-03231152C1335177
DiseaseHeadache, type 2 diabetes mellitus

NLGN1 GTF2I

3.61e-03231152HP_0002315, MONDO_0005148
Diseasefrailty measurement

NLGN1 LRPPRC

3.61e-03231152EFO_0009885
Diseaseasthma, allergic disease

SUOX RERE D2HGDH

3.68e-03791153MONDO_0004979, MONDO_0005271
DiseaseEndometrioma

LRRK2 MED14 DICER1 HSD17B1

3.69e-031611154C0269102
DiseaseEndometriosis

LRRK2 MED14 DICER1 HSD17B1

3.69e-031611154C0014175

Protein segments in the cluster

PeptideGeneStartEntry
RKPDNYMTLSRLIDL

TTC21B

981

Q7Z4L5
TMEALLYKPIDRVTR

ABR

231

Q12979
PLARYIDDEDLDRML

BUD13

521

Q9BRD0
RALYLVRIPTMTLEE

BTBD6

331

Q96KE9
LRLDLAGRELTDYLM

POTEKP

176

Q9BYX7
LRLDLAGRDLTDYLM

ACTB

176

P60709
LRLDLAGRDLTDYLM

ACTG1

176

P63261
DYSPNELLRMELAIL

CCNI2

226

Q6ZMN8
ERIALTPFMRLLFEI

DNAH11

2286

Q96DT5
YSSELFDDPMLRLTL

ABCA3

946

Q99758
ALYLIRIPTMALDDF

BTBD3

316

Q9Y2F9
IMRLDLAGRDLTDYL

ACTG2

176

P63267
LMRISERPSVYLAAR

CYLC2

81

Q14093
TDRSGLYERLLMELE

DICER1

261

Q9UPY3
PLSRDILMETLLYEQ

BIK

6

Q13323
DLVLRMLEYEPAARI

DYRK1B

406

Q9Y463
SPSLMEDYELRQLVL

EFR3A

466

Q14156
RGMERSLLYTELLAR

NWD1

801

Q149M9
MLSPEAERVLRYLVE

PDRG1

1

Q9NUG6
LSELEPATEYMARVR

OSMR

391

Q99650
LMSPREESAREYLLS

PTPN5

266

P54829
ERLTLPRLADTYEML

GGT3P

206

A6NGU5
LRLDLAGRELPDYLM

POTEF

876

A5A3E0
RRYLLSLEEERPALM

PATL1

541

Q86TB9
YRSLMPRTLESQITL

HS3ST2

161

Q9Y278
PIKRSEMLRDIIREY

MAGED1

491

Q9Y5V3
EPMESVLEDRCLYLR

GATC

76

O43716
VTMLLRNPYLLSEEE

NEMF

406

O60524
EMVRYLLSKRLVELP

LRRK1

101

Q38SD2
LLLLERVPAMSYVSI

SLC2A4

371

P14672
LEDYMALFPSVRILR

GALNT10

196

Q86SR1
LLAEVLASLLDMVYR

DOP1B

1901

Q9Y3R5
LYLLSAAEEIRDPLM

HLCS

386

P50747
TVLPHSLLEDMVYRL

FSIP2

5111

Q5CZC0
DLKSYLRSLRPEMEN

IGF1R

1086

P08069
LLSPDIIMNLLLSYR

MAP3K6

271

O95382
MPRDYSPELAELIRT

NEK4

226

P51957
RDKLQDRMSPYLVSL

FMO4

541

P31512
YRRDDLEMAALDPDL

LMO7

496

Q8WWI1
SRLINRLLEISPYML

LRRK2

1706

Q5S007
RLLEISPYMLSGRER

LRRK2

1711

Q5S007
ERRYIPDAMNLILLL

LRPPRC

331

P42704
LRITEDGTLLYTMRL

GABRA1

146

P14867
DDILVYRMIPAESRS

LRFN3

466

Q9BTN0
YRMIPAESRSFLLTD

LRFN3

471

Q9BTN0
LVLDARSDLPTAMEY

ITGA11

791

Q9UKX5
DYTLAMRRSPDDVPL

NLGN1

801

Q8N2Q7
EPLSMLQRLTEDLEY

OSBP2

546

Q969R2
LPEELARMYRDDITI

PDP1

506

Q9P0J1
DLRDDPKTLARLLYM

RHOJ

136

Q9H4E5
MESERSPLYRQLIDL

DSTYK

296

Q6XUX3
MSRLTPERNLDLERY

MACF1

1231

Q9UPN3
RAYSELMVLTDLLPR

MED14

61

O60244
LRLDLAGRELPDYLM

POTEE

876

Q6S8J3
LTLPEDLARMYRDDI

PDP2

496

Q9P2J9
IRPLPEEMLSYARDD

EXOSC10

426

Q01780
PEYSSEEIMRERLLA

HECTD1

2586

Q9ULT8
ILDTMYPELSARART

ICE1

1751

Q9Y2F5
IYPELMDLRSRTTPI

GPCPD1

531

Q9NPB8
SRDPTMYLALRNLIL

KDM1B

301

Q8NB78
MPTIERATLTRDFYL

CASP5

416

P51878
LIATVTRLMERLLDY

DOCK4

1151

Q8N1I0
TRMVHLERLIPDTLY

COL12A1

1986

Q99715
IALPSLRILYMTDEV

MT-CO2

76

P00403
EVDYAPSLMARLILE

CDIN1

91

Q9Y2V0
PSLMARLILERFLQE

CDIN1

96

Q9Y2V0
EDYIPASLIERMTAL

FRMPD2

496

Q68DX3
PLLMEYSRQELLRKE

GALT

216

P07902
TTERFLPLLRMRLDD

HSD17B1

256

P14061
LADRRYDMLPSVLSA

DIS3L

531

Q8TF46
PTLDTIRYSALMELL

DNAH7

1951

Q8WXX0
LDRERIPVYSLMAKA

FAT3

3091

Q8TDW7
MEELREILSSLLPFV

BTBD7

506

Q9P203
VRASERLAEIDMPYL

LYG1

51

Q8N1E2
LLMRFLPTEYERSLI

FMNL1

751

O95466
DPKMARVALESLYRL

FRY

396

Q5TBA9
TYTLAMASLEVIRRP

HELZ2

551

Q9BYK8
KAPSYLEISSMRRIL

GTF2I

916

P78347
LIMNLSRDAYEIRLL

PEX11B

131

O96011
LEESSGYMEPTLRIL

RYR2

4561

Q92736
RMLSEDLPSLELYVN

IFT140

936

Q96RY7
LEMRKRELRPSSDEY

CFAP74

1166

Q9C0B2
ELSRYVEERDFIMPL

D2HGDH

176

Q8N465
ERLTLPRLADTYEML

GGT2P

206

P36268
RARELYVDDSPLELM

NUP210L

136

Q5VU65
YVDDSPLELMVRALD

NUP210L

141

Q5VU65
DIDYMISDTLELLRP

UPF2

971

Q9HAU5
ADEPRMSIRAIYLAI

MROH2A

416

A6NES4
ERVYSMNPSIRLLLI

HS3ST1

131

O14792
LLIRRTELLMAYLEA

MIGA1

591

Q8NAN2
ERYSVILLDTLLGRM

SFTPB

251

P07988
MSSLPLSYREALERL

SYNE2

3386

Q8WXH0
LSPAYLISEAMRRSR

GFOD1

371

Q9NXC2
MDYLSLLRDALVQPL

RFC1

996

P35251
LLTYLISELEAARML

FAM98A

111

Q8NCA5
LMRALDPLLYEKETL

RABGGTA

391

Q92696
IFPAILSMDLYRRED

PTCH1

591

Q13635
PSDIRDYVMLRSAIL

ST6GALNAC2

231

Q9UJ37
MEIIYLSEVLDTPLL

CCT8L1P

321

A6NM43
MEIIYLSEVLDTPLL

CCT8L2

321

Q96SF2
AEPDMLRKAEEYLRL

ORC6

16

Q9Y5N6
LRLDLAGRELTDYLM

POTEI

876

P0CG38
LRPEMSYPDRLAAER

RERE

1386

Q9P2R6
ASLTYPLDLVRARMA

SLC25A42

146

Q86VD7
RETPENLAKLLTRMY

FARSB

321

Q9NSD9
SYDLEPFLRRLGMID

SERPINB8

276

P50452
ADLYEPRGRMTLADI

SLC25A13

276

Q9UJS0
LLYPEKRDILMDRIL

CNOT1

226

A5YKK6
DYLRRFESIPDMLEL

UGP2

441

Q16851
DPDLSYKLALRAMRL

ZSWIM5

751

Q9P217
PALELTRKMLTYDRR

REV3L

2926

O60673
VLLELDMPSRTTRDY

KIF3B

661

O15066
IYAVTPLLEDALMDR

SF3B1

1166

O75533
LRDSVYKTLIMRPDL

ZMIZ2

451

Q8NF64
PSYLSEIEMLLAIEI

TOPAZ1

1581

Q8N9V7
YDTTILTEMRLEPII

UBP1

266

Q9NZI7
LYLRILMAIDSELVD

XPOT

141

O43592
LARAMDPEAEVLLAY

SUOX

336

P51687
LERLAMILYDIPDIR

FARS2

316

O95363
ATILVEYLLDRLPEM

TRRAP

686

Q9Y4A5
RFPALETLMLDDNRL

XRRA1

226

Q6P2D8
LEIPRDASLMLYFRI

TYK2

91

P29597
TYSAISREDLLMRLL

AK7

96

Q96M32
LLDMVENYPTALRSL

LRRC73

221

Q5JTD7