Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionunmethylated CpG binding

KDM2B FBXL19

5.19e-0510222GO:0045322
GeneOntologyMolecularFunctionhistone demethylase activity

KDM2B FBXL19

5.28e-0431222GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM2B FBXL19

5.63e-0432222GO:0140457
GeneOntologyMolecularFunctiondemethylase activity

KDM2B FBXL19

1.07e-0344222GO:0032451
GeneOntologyMolecularFunctionzinc ion binding

KDM2B RBBP6 ZNF318 ZCCHC3 FBXL19

2.44e-03891225GO:0008270
GeneOntologyBiologicalProcessprotein demethylation

KDM2B FBXL19

5.32e-0510232GO:0006482
GeneOntologyBiologicalProcessprotein dealkylation

KDM2B FBXL19

5.32e-0510232GO:0008214
DomainPHD_4

KDM2B FBXL19

4.35e-063232PF16866
Domainzf-CXXC

KDM2B FBXL19

7.92e-0511232PF02008
DomainZF_CXXC

KDM2B FBXL19

7.92e-0511232PS51058
DomainZnf_CXXC

KDM2B FBXL19

7.92e-0511232IPR002857
DomainZnf_PHD-finger

KDM2B FBXL19 SP140

1.21e-0479233IPR019787
DomainPHD

KDM2B FBXL19 SP140

1.73e-0489233SM00249
DomainZnf_PHD

KDM2B FBXL19 SP140

1.85e-0491233IPR001965
DomainZF_PHD_2

KDM2B FBXL19 SP140

2.10e-0495233PS50016
DomainZF_PHD_1

KDM2B FBXL19 SP140

2.16e-0496233PS01359
DomainLeu-rich_rpt_Cys-con_subtyp

KDM2B FBXL19

2.45e-0419232IPR006553
DomainLRR_CC

KDM2B FBXL19

2.45e-0419232SM00367
Domainzf-CCHC

RBBP6 ZCCHC3

3.61e-0423232PF00098
Domain-

RBBP6 ZCCHC3

4.63e-04262324.10.60.10
DomainZnf_FYVE_PHD

KDM2B FBXL19 SP140

7.54e-04147233IPR011011
DomainZF_CCHC

RBBP6 ZCCHC3

8.42e-0435232PS50158
DomainFBOX

KDM2B FBXL19

1.85e-0352232SM00256
Domain-

KDM2B RBBP6 FBXL19 SP140

2.03e-034492343.30.40.10
DomainZnF_C2HC

RBBP6 ZCCHC3

2.07e-0355232SM00343
DomainZnf_CCHC

RBBP6 ZCCHC3

2.07e-0355232IPR001878
DomainZnf_RING/FYVE/PHD

KDM2B RBBP6 FBXL19 SP140

2.20e-03459234IPR013083
DomainZinc_finger_PHD-type_CS

FBXL19 SP140

2.88e-0365232IPR019786
DomainF-box

KDM2B FBXL19

3.06e-0367232PF00646
DomainFBOX

KDM2B FBXL19

3.52e-0372232PS50181
DomainF-box_dom

KDM2B FBXL19

3.81e-0375232IPR001810
DomainGrowth_fac_rcpt_

RSPO3 FBXL19

1.56e-02156232IPR009030
Pubmed

Human transcription factor protein interaction networks.

UBN2 KDM2B RBBP6 INO80D ELF3 ZNF318 ZCCHC3 RPS8 RBM28

2.43e-07142924935140242
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

UBN2 KDM2B RBBP6 INO80D CTR9 ZNF318 RPS8 RBM28

1.55e-06129424830804502
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

UBN2 SPART KDM2B RBBP6 CTR9 ZNF318

2.36e-0658824638580884
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

CCDC14 RBBP6 ZNF318 RPS8

7.42e-0618424432908313
Pubmed

DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.

KDM2B FBXL19

2.05e-051024229276034
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

UBN2 KDM2B CTR9 HEXIM1

3.24e-0526824433640491
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

UBN2 KDM2B RBBP6 INO80D CTR9 ZNF318 HEXIM1

4.90e-05149724731527615
Pubmed

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.

KDM2B FBXL19

6.94e-051824228614300
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

UBN2 INO80D CTR9 ZNF318 HEXIM1 RBM28

8.27e-05110324634189442
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

SPART CTR9 ZNF318 RPS8

9.86e-0535724437059091
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

RBBP6 ZCCHC3 HEXIM1 RPS8 RBM28

1.10e-0471324529802200
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

RBBP6 CTR9 ZCCHC3 RPS8 RBM28

1.23e-0473124529298432
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

KLHDC4 KDM2B RBBP6 CTR9 ZNF318

1.61e-0477424515302935
Pubmed

A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.

CCDC134 SPART RPS8

1.87e-0416224321890473
Pubmed

A human MAP kinase interactome.

CCDC14 RBBP6 MKNK2 SLC4A4

3.21e-0448624420936779
Pubmed

Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility.

SPART RPS8

3.86e-044224225015289
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

UBN2 CTR9 ZNF318

4.70e-0422224337071664
Pubmed

The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.

RBBP6 ZCCHC3 RPS8 RBM28

5.01e-0454724437267103
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

UBN2 KDM2B RBBP6 ZNF318

5.08e-0454924438280479
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

CCDC14 SPART ZNF318

6.04e-0424224334011540
InteractionCDX1 interactions

UBN2 RBBP6 ZCCHC3 RBM28

2.30e-0680244int:CDX1
InteractionDHX8 interactions

RBBP6 CTR9 ZNF318 RPS8 RBM28

2.09e-05292245int:DHX8
InteractionRBM4 interactions

RBBP6 HEXIM1 MKNK2 RPS8 RBM28

3.20e-05319245int:RBM4
CytobandEnsembl 112 genes in cytogenetic band chr2q32

ZNF804A ANKAR

1.52e-03110242chr2q32
GeneFamilyZinc fingers CXXC-type

KDM2B FBXL19

4.22e-0512152136
GeneFamilyPHD finger proteins

KDM2B FBXL19 SP140

5.20e-059015388
GeneFamilyF-box and leucine rich repeat proteins

KDM2B FBXL19

1.34e-0421152558
CoexpressionGSE17721_CTRL_VS_CPG_4H_BMDC_UP

CTR9 ELF3 HEXIM1 MKNK2 RPS8

9.29e-07200245M3761
CoexpressionGSE17721_CTRL_VS_LPS_6H_BMDC_UP

KLHDC4 CTR9 MKNK2 RPS8

3.10e-05200244M3691
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

ZNF804A ZNF318 SP140

7.55e-05154243e16f200391537aa1002b0079481b94e1fb86b9ad
ToppCell5'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC14 ELF3 HEXIM1

1.03e-0417124348125d825ca2d7ef34564250f5b47d2a579e03c9
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF318 RPS8 SP140

1.08e-0417424326ca6ebaa0081108d44c01f8ca56a63724f1c99d
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF318 RPS8 SP140

1.08e-041742437c8704766dd4c80250754b5ee9907b342b9c2623
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF318 RPS8 SP140

1.08e-041742439aa2168d3bcef7cdc5a47442618cb8e9eb24c95b
ToppCellBasal-basal-3|World / Class top

ELF3 HEXIM1 MKNK2

1.10e-04175243a0d7ced5204a9efbbb91ac99410a088f8ed2df0f
ToppCellmetastatic_Brain-Myeloid_cells-Activated_DCs|Myeloid_cells / Location, Cell class and cell subclass

KDM2B FBXL19 SLC4A4

1.12e-041762439c1f255de3082b3da4bef2a9bdff710cfd48261f
ToppCellC_00|World / shred on cell type and cluster

CCDC14 ELF3 RPS8

1.18e-04179243da2dadc3266ffebd4a34ac61bfa05fddcadcde4c
ToppCelldroplet-Spleen-nan-18m-Lymphocytic|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF318 RPS8 SP140

1.26e-0418324328cbf909424f3be4491d49832f0aca0386560814
ToppCelldroplet-Spleen-nan-18m-Lymphocytic-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF318 RPS8 SP140

1.26e-041832433fa608aa6b119869ec3280dc388dfee57160e63a
ToppCellControl-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

CCDC14 SPART ZNF318

1.28e-04184243ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ELF3 HEXIM1 SLC4A4

1.28e-0418424301c19a830348ab0b9c02c1546a439de70ee10f97
ToppCellfacs-BAT-Fat-3m-Lymphocytic-B_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF318 RPS8 SP140

1.34e-0418724363cc89ce24d3f8fb13479a501a20bfbd798d151a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF318 ANKAR MKNK2

1.36e-04188243d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CCDC14 ELF3 SLC4A4

1.43e-0419124334cc997e4e5c727495f321e6807a84aa124da486
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC14 ELF3 HEXIM1

1.43e-0419124354f07e4de61735051498846afb44b1798bed8144
ToppCellCOVID_non-vent-Lymphocytic-B_cell-|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ZNF318 RPS8 SP140

1.47e-0419324391955c3773c9729a96e82f240f06b072367970d9
ToppCellCOVID_non-vent-Lymphocytic-B_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

ZNF318 RPS8 SP140

1.47e-0419324332d139f922cd19adc1cc1e0e9a828115be9945d6
ToppCellsaliva-Mild-Moderate_progression_d12-25|saliva / Compartment, severity and other cell annotations on 10x 3' data (130k)

ELF3 MKNK2 NEUROD2

1.52e-041952436eb123cbea7bcadbdef086a8c230f0a73caf4930
ToppCellBasal-basal-5|World / Class top

ELF3 HEXIM1 RPS8

1.56e-04197243267db5fc5d59eeadbc7746af08ed6e3cb3da8f3a
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

INO80D ELF3 SLC4A4

1.56e-0419724301e9505d947e5a5f005d1eab96301f84fc194809
ToppCellGoblet_2|World / shred by cell class for nasal brushing

ELF3 MKNK2 RPS8

1.59e-041982436f9ffcef84dd2ab6084281f7b5169335e323304d
ToppCellMild/Remission-B_intermediate-0|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ZNF804A MKNK2 RPS8

1.61e-04199243592111591f0f6816fc56620cb555eb48dabf0758
DiseaseDiuretic use measurement

KDM2B RSPO3 FAM186A ZNF318

8.45e-06169234EFO_0009928
DiseaseCalcium channel blocker use measurement

KDM2B RSPO3 ZNF318

5.90e-04213233EFO_0009930
DiseaseAgents acting on the renin-angiotensin system use measurement

KDM2B RSPO3 ZNF318

2.17e-03335233EFO_0009931
Diseasecarpal tunnel syndrome

CCDC134 MKNK2

2.18e-0389232EFO_0004143

Protein segments in the cluster

PeptideGeneStartEntry
KHGKRKRGRPRKLSK

ELF3

241

P78545
RKRKLGGRAKKVREP

CCDC14

11

Q49A88
PRKKVKGGRERHLKK

FBXL19

226

Q6PCT2
HRGPKIRLRDKGKVK

RBM28

676

Q9NW13
KRGKEHRRKLKPKIQ

ANKAR

1351

Q7Z5J8
KFRKRKGEKRPRPNH

KIAA0895

31

Q8NCT3
RQLGKKKHRRRPSKK

HEXIM1

146

O94992
IPDAKKRGKKKKRGR

MKNK2

56

Q9HBH9
GDGKGNKHKKHRKRR

RBBP6

926

Q7Z6E9
GPEEKKKVKMRRKRR

KDM2B

926

Q8NHM5
EGGERKKKKRRRHPK

CTR9

951

Q6PD62
KKKKRRRHPKGEEGS

CTR9

956

Q6PD62
KHKKKRRRGPRRPQK

INO80D

546

Q53TQ3
KSEKKKRRRGRKEEP

KLHDC4

351

Q8TBB5
LGPHRRREKGKEKQK

FAM186A

956

A6NE01
RRKTGGKRKPYHKKR

RPS8

11

P62241
RRKKEEKRKEIRKGP

CCDC134

206

Q9H6E4
NKDVRHKGKRGKRAK

SPART

376

Q8N0X7
KYGGKPRKHRKDRLQ

UBN2

186

Q6ZU65
PRKKKGAAEAGRRKK

ZCCHC3

111

Q9NUD5
RGKKGRERKRKKPNK

RSPO3

211

Q9BXY4
RRRRHKRKTGHKEKK

SLC4A4

41

Q9Y6R1
TLGKPKRKRRKKRGH

SP140

491

Q13342
MLRKKRREKDGHKDP

ZNF318

926

Q5VUA4
CKPKKKRRRKRGRFH

ZNF804A

806

Q7Z570
AEGERPKKRGPKKRK

NEUROD2

96

Q15784