Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionolfactory receptor activity

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

8.22e-164317319GO:0004984
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC5A5 GJA9 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 ABCG4 GJA5 ATP13A4 TMC2 KCNC1 SLC22A16 KCNC3 KCNC4 SLC16A1 PIEZO1 ABCB5 TRPC3 GJA10 FLVCR2 MFSD4B ABCG8 TFRC

1.90e-1211807324GO:0022857
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 P2RY13 OR1F12P OR3A3 OR5T2 OR2A25 SMO OR8K3 OR1D4 OR1J2 OR6N1

3.57e-128847321GO:0004930
GeneOntologyMolecularFunctiontransporter activity

SLC5A5 GJA9 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 ABCG4 GJA5 ATP13A4 TMC2 KCNC1 SLC22A16 KCNC3 KCNC4 SLC16A1 PIEZO1 ABCB5 TRPC3 GJA10 FLVCR2 MFSD4B ABCG8 TFRC

1.23e-1112897324GO:0005215
GeneOntologyMolecularFunctionodorant binding

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR2A4 OR5T2 OR2A25 OR8K3

3.35e-111277310GO:0005549
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 P2RY13 OR1F12P OR3A3 OR5T2 OR2A25 KDR SMO OR8K3 OR1D4 OR1J2 OR6N1 IFNAR2

2.29e-1013537323GO:0004888
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 ATP13A4 TMC2 KCNC1 KCNC3 KCNC4 TRPC3 TFRC

1.21e-084657313GO:0046873
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 ATP13A4 TMC2 KCNC1 KCNC3 KCNC4 SLC16A1 PIEZO1 TRPC3 TFRC

1.40e-086647315GO:0008324
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 ATP13A4 TMC2 KCNC1 KCNC3 KCNC4 SLC16A1 TRPC3 TFRC

5.25e-086277314GO:0022890
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 ATP13A4 TMC2 KCNC1 KCNC3 KCNC4 SLC16A1 PIEZO1 TRPC3 TFRC

1.43e-077937315GO:0015075
GeneOntologyMolecularFunctionchannel activity

GJA9 SLC24A5 CACNG2 KCNK18 GJA5 TMC2 KCNC1 KCNC3 KCNC4 PIEZO1 TRPC3 GJA10

4.12e-075257312GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GJA9 SLC24A5 CACNG2 KCNK18 GJA5 TMC2 KCNC1 KCNC3 KCNC4 PIEZO1 TRPC3 GJA10

4.20e-075267312GO:0022803
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 ATP13A4 TMC2 KCNC1 KCNC3 KCNC4 SLC16A1 TRPC3 TFRC

5.30e-077587314GO:0015318
GeneOntologyMolecularFunctionmonoatomic cation channel activity

SLC24A5 CACNG2 KCNK18 TMC2 KCNC1 KCNC3 KCNC4 PIEZO1 TRPC3

4.33e-06343739GO:0005261
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC5A5 SLC24A5 SLC6A18 SLC6A9 ABCG4 ATP13A4 SLC16A1 ABCB5 MFSD4B ABCG8

8.90e-064777310GO:0022804
GeneOntologyMolecularFunctionsymporter activity

SLC5A5 SLC24A5 SLC6A18 SLC6A9 SLC16A1 MFSD4B

1.83e-05150736GO:0015293
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNG2 KCNK18 TMC2 KCNC1 KCNC3 KCNC4

1.97e-05152736GO:0022843
GeneOntologyMolecularFunctiongated channel activity

CACNG2 KCNK18 TMC2 KCNC1 KCNC3 KCNC4 PIEZO1 TRPC3

2.94e-05334738GO:0022836
GeneOntologyMolecularFunctionmonoatomic ion channel activity

SLC24A5 CACNG2 KCNK18 TMC2 KCNC1 KCNC3 KCNC4 PIEZO1 TRPC3

4.37e-05459739GO:0005216
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNG2 KCNK18 TMC2 KCNC1 KCNC3 KCNC4

5.42e-05182736GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNG2 KCNK18 TMC2 KCNC1 KCNC3 KCNC4

5.76e-05184736GO:0022832
GeneOntologyMolecularFunctiongap junction channel activity

GJA9 GJA5 GJA10

1.02e-0425733GO:0005243
GeneOntologyMolecularFunctiondelayed rectifier potassium channel activity

KCNC1 KCNC3 KCNC4

1.44e-0428733GO:0005251
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

SLC24A5 CACNG2 ATP13A4 TMC2 TRPC3

2.30e-04151735GO:0015085
GeneOntologyMolecularFunctionwide pore channel activity

GJA9 GJA5 GJA10

3.33e-0437733GO:0022829
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

SLC24A5 KCNK18 KCNC1 KCNC3 KCNC4

3.66e-04167735GO:0015079
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNK18 KCNC1 KCNC3 KCNC4

5.33e-04102734GO:0005249
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCG4 ATP13A4 ABCB5 ABCG8

6.85e-04109734GO:0042626
GeneOntologyMolecularFunctionpolyamine transmembrane transporter activity

ATP13A4 SLC22A16

7.10e-0411732GO:0015203
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC5A5 SLC24A5 SLC6A18 SLC6A9 SLC16A1 MFSD4B

7.47e-04296736GO:0015291
GeneOntologyMolecularFunctionABC-type transporter activity

ABCG4 ABCB5 ABCG8

7.65e-0449733GO:0140359
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC5A5 SLC24A5 SLC6A18 SLC6A9 ATP13A4 SLC16A1

8.15e-04301736GO:0022853
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC5A5 SLC6A18 SLC6A9 SLC16A1

9.51e-04119734GO:0015294
GeneOntologyMolecularFunctionpotassium channel activity

KCNK18 KCNC1 KCNC3 KCNC4

1.25e-03128734GO:0005267
GeneOntologyMolecularFunctioncalcium channel activity

SLC24A5 CACNG2 TMC2 TRPC3

1.28e-03129734GO:0005262
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

KCNC1 KCNC4

1.73e-0317732GO:0099508
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

TMC2 PIEZO1

1.94e-0318732GO:0008381
GeneOntologyMolecularFunctionmonoatomic anion:sodium symporter activity

SLC5A5 SLC6A18

2.17e-0319732GO:0015373
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A18 SLC6A9

3.17e-0323732GO:0005283
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC5A5 SLC6A18 SLC6A9

3.26e-0381733GO:0015370
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC5A5 SLC24A5 SLC6A18 SLC6A9

3.57e-03171734GO:0015081
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC5A5 SLC6A18

4.05e-0326732GO:0015296
GeneOntologyMolecularFunctionprimary active transmembrane transporter activity

ABCG4 ATP13A4 ABCB5 ABCG8

4.12e-03178734GO:0015399
GeneOntologyMolecularFunctionMAP kinase kinase kinase activity

RAF1 ARAF

4.36e-0327732GO:0004709
GeneOntologyMolecularFunctioncalcium-activated cation channel activity

KCNK18 TRPC3

4.36e-0327732GO:0005227
GeneOntologyMolecularFunctionmannosyltransferase activity

DPY19L2 DPY19L2P2

4.69e-0328732GO:0000030
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A18 SLC6A9

5.02e-0329732GO:0005416
GeneOntologyMolecularFunctionmonoatomic ion-gated channel activity

KCNK18 TRPC3

5.72e-0331732GO:0022839
GeneOntologyMolecularFunctionneutral L-amino acid transmembrane transporter activity

SLC6A18 SLC6A9

9.86e-0341732GO:0015175
GeneOntologyBiologicalProcessdetection of stimulus

OR8H3 OR8D1 OR2A7 OR8D2 TMC2 OR5AK2 OR9K2 OR1B1 OR2G6 PIEZO1 OR2A4 TRPC3 CDS2 OR52N5 OR1D5 OR1F12P OR3A3 OR5T2 OR2A25 SMO OR8K3 GJA10 OR1D4 OR1J2 OR6N1

1.85e-187227425GO:0051606
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

6.33e-164327419GO:0050911
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR8H3 OR8D1 OR2A7 OR8D2 TMC2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 GJA10 OR1D4 OR1J2 OR6N1

7.60e-165827421GO:0050906
GeneOntologyBiologicalProcesssensory perception of smell

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

2.42e-154657419GO:0007608
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

5.20e-154857419GO:0050907
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

2.10e-145247419GO:0009593
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

4.54e-145477419GO:0007606
GeneOntologyBiologicalProcesssensory perception

OR8H3 OR8D1 OR2A7 OR8D2 TMC2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR1F12P CDH23 OR3A3 OR5T2 OR2A25 OR8K3 GJA10 OR1D4 OR1J2 OR6N1

1.24e-1110727422GO:0007600
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

OR8H3 NLN OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 ATRNL1 OR2A4 OR52N5 OR1D5 P2RY13 OR1F12P OR3A3 OR5T2 OR2A25 SMO OR8K3 OR1D4 OR1J2 OR6N1

3.01e-1013957423GO:0007186
GeneOntologyBiologicalProcessmonoatomic cation transport

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 GJA5 ATP13A4 TMC2 KCNC1 KCNC3 KCNC4 SLC16A1 PIEZO1 TRPC3 CDH23 FLVCR2 MFSD4B TFRC

1.64e-0811577419GO:0006812
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 GJA5 ATP13A4 TMC2 KCNC1 SLC22A16 KCNC3 KCNC4 SLC16A1 PIEZO1 TRPC3 CDH23 FLVCR2 MFSD4B TFRC

4.73e-0813747420GO:0006811
GeneOntologyBiologicalProcessmetal ion transport

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 GJA5 ATP13A4 TMC2 KCNC1 KCNC3 KCNC4 TRPC3 CDH23 FLVCR2 MFSD4B TFRC

6.63e-0810007417GO:0030001
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 ATP13A4 TMC2 KCNC1 KCNC3 KCNC4 SLC16A1 PIEZO1 TRPC3

5.51e-069427414GO:0098655
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 ATP13A4 TMC2 KCNC1 KCNC3 KCNC4 SLC16A1 TRPC3

2.18e-059227413GO:0098662
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 ATP13A4 TMC2 KCNC1 KCNC3 KCNC4 SLC16A1 PIEZO1 TRPC3

3.64e-0511157414GO:0034220
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

SLC5A5 SLC24A5 CACNG2 SLC6A18 KCNK18 SLC6A9 ATP13A4 TMC2 KCNC1 KCNC3 KCNC4 SLC16A1 TRPC3

6.00e-0510177413GO:0098660
GeneOntologyBiologicalProcessregulation of membrane potential

CACNG2 KCNK18 GJA5 KCNC1 KCNC3 KCNC4 PIEZO1 ABCB5 KDR

1.71e-04559749GO:0042391
GeneOntologyBiologicalProcessreflex

CACNG2 TMC2 CDH23

1.85e-0431743GO:0060004
GeneOntologyBiologicalProcesspeptidyl-tryptophan modification

DPY19L2 DPY19L2P2

1.89e-046742GO:0018211
GeneOntologyBiologicalProcessprotein C-linked glycosylation via tryptophan

DPY19L2 DPY19L2P2

1.89e-046742GO:0018317
GeneOntologyBiologicalProcessprotein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan

DPY19L2 DPY19L2P2

1.89e-046742GO:0018406
GeneOntologyBiologicalProcessprotein C-linked glycosylation

DPY19L2 DPY19L2P2

1.89e-046742GO:0018103
GeneOntologyBiologicalProcesstransport across blood-brain barrier

SLC5A5 SLC6A9 SLC16A1 TFRC

2.71e-0487744GO:0150104
GeneOntologyBiologicalProcessvascular transport

SLC5A5 SLC6A9 SLC16A1 TFRC

2.83e-0488744GO:0010232
GeneOntologyBiologicalProcessdetection of external stimulus

TMC2 PIEZO1 TRPC3 CDS2 GJA10

3.95e-04173745GO:0009581
GeneOntologyBiologicalProcessdetection of abiotic stimulus

TMC2 PIEZO1 TRPC3 CDS2 GJA10

4.17e-04175745GO:0009582
GeneOntologyBiologicalProcesspotassium ion transport

SLC24A5 KCNK18 GJA5 KCNC1 KCNC3 KCNC4

4.35e-04272746GO:0006813
GeneOntologyCellularComponentplasma membrane protein complex

GJA9 CACNG2 GJA5 KCNC1 KCNC3 KCNC4 CDH23 PORCN GJA10 C8B ABCG8 CHUK TFRC

3.37e-067857413GO:0098797
GeneOntologyCellularComponentconnexin complex

GJA9 GJA5 GJA10

6.25e-0522743GO:0005922
GeneOntologyCellularComponentmembrane protein complex

GJA9 CACNG2 SYNRG GJA5 KCNC1 KCNC3 KCNC4 TRPC3 CDH23 PORCN GJA10 C8B ABCG8 CHUK TFRC

2.05e-0414987415GO:0098796
GeneOntologyCellularComponentcalyx of Held

KCNC1 KCNC3 KCNC4

2.80e-0436743GO:0044305
GeneOntologyCellularComponentgap junction

GJA9 GJA5 GJA10

3.03e-0437743GO:0005921
GeneOntologyCellularComponentneuronal cell body membrane

KCNC1 KCNC3 KCNC4

4.75e-0443743GO:0032809
GeneOntologyCellularComponentcell body membrane

KCNC1 KCNC3 KCNC4

6.17e-0447743GO:0044298
GeneOntologyCellularComponentdendrite membrane

KCNC1 KCNC3 KCNC4

1.03e-0356743GO:0032590
GeneOntologyCellularComponentcleavage furrow

OR2A7 OR2A4 MASTL

1.32e-0361743GO:0032154
GeneOntologyCellularComponentmitotic spindle midzone

OR2A7 OR2A4

1.44e-0316742GO:1990023
GeneOntologyCellularComponentcation channel complex

CACNG2 KCNC1 KCNC3 KCNC4 TRPC3

1.48e-03235745GO:0034703
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNG2 KCNC1 KCNC3 KCNC4 TRPC3 PORCN

2.21e-03378746GO:0034702
GeneOntologyCellularComponentaxolemma

KCNC1 KCNC3

2.49e-0321742GO:0030673
GeneOntologyCellularComponenttransmembrane transporter complex

CACNG2 KCNC1 KCNC3 KCNC4 TRPC3 PORCN ABCG8

2.50e-03523747GO:1902495
GeneOntologyCellularComponentstereocilium tip

TMC2 CDH23

2.73e-0322742GO:0032426
GeneOntologyCellularComponentcell division site

OR2A7 OR2A4 MASTL

2.88e-0380743GO:0032153
GeneOntologyCellularComponentneuron projection membrane

KCNC1 KCNC3 KCNC4

3.09e-0382743GO:0032589
GeneOntologyCellularComponenttransporter complex

CACNG2 KCNC1 KCNC3 KCNC4 TRPC3 PORCN ABCG8

3.30e-03550747GO:1990351
GeneOntologyCellularComponentvoltage-gated potassium channel complex

KCNC1 KCNC3 KCNC4

4.14e-0391743GO:0008076
GeneOntologyCellularComponentcell projection membrane

SLC6A18 KCNC1 KCNC3 KCNC4 PIEZO1 SMO

4.22e-03431746GO:0031253
DomainOlfact_rcpt

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

5.03e-163937319IPR000725
Domain7tm_1

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 P2RY13 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

8.24e-136777320PF00001
DomainG_PROTEIN_RECEP_F1_1

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 P2RY13 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

1.02e-126857320PS00237
DomainG_PROTEIN_RECEP_F1_2

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 P2RY13 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

1.20e-126917320PS50262
DomainGPCR_Rhodpsn

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 P2RY13 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

1.23e-126927320IPR000276
DomainGPCR_Rhodpsn_7TM

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 P2RY13 OR3A3 OR5T2 OR2A25 OR8K3 OR1J2 OR6N1

6.71e-116707318IPR017452
DomainK_chnl_volt-dep_Kv3

KCNC1 KCNC3 KCNC4

2.29e-074733IPR003974
DomainPotassium_chann

KCNC3 KCNC4

1.51e-052732PF11404
DomainK_chnl_volt-dep_Kv3_ID

KCNC3 KCNC4

1.51e-052732IPR021105
DomainCONNEXINS_1

GJA9 GJA5 GJA10

5.31e-0519733PS00407
DomainCONNEXINS_2

GJA9 GJA5 GJA10

6.23e-0520733PS00408
DomainConnexin

GJA9 GJA5 GJA10

6.23e-0520733IPR000500
DomainConnexin_CCC

GJA9 GJA5 GJA10

6.23e-0520733IPR019570
DomainConnexin_N

GJA9 GJA5 GJA10

6.23e-0520733IPR013092
DomainConnexin

GJA9 GJA5 GJA10

6.23e-0520733PF00029
DomainConnexin_CCC

GJA9 GJA5 GJA10

6.23e-0520733SM01089
DomainConnexin_CS

GJA9 GJA5 GJA10

6.23e-0520733IPR017990
DomainCNX

GJA9 GJA5 GJA10

6.23e-0520733SM00037
DomainABC_2_trans

ABCG4 ABCG8

1.50e-045732IPR013525
DomainABC2_membrane

ABCG4 ABCG8

1.50e-045732PF01061
DomainK_chnl_volt-dep_Kv

KCNC1 KCNC3 KCNC4

1.57e-0427733IPR003968
DomainRBD

RAF1 ARAF

2.24e-046732PF02196
DomainVG_K_chnl

KCNC1 KCNC3 KCNC4

2.87e-0433733IPR028325
DomainRBD

RAF1 ARAF

3.12e-047732SM00455
DomainRBD_dom

RAF1 ARAF

3.12e-047732IPR003116
DomainRBD

RAF1 ARAF

3.12e-047732PS50898
DomainABC_transporter_CS

ABCG4 ABCB5 ABCG8

5.89e-0442733IPR017871
DomainABC_tran

ABCG4 ABCB5 ABCG8

8.73e-0448733PF00005
DomainABC_TRANSPORTER_2

ABCG4 ABCB5 ABCG8

8.73e-0448733PS50893
DomainABC_TRANSPORTER_1

ABCG4 ABCB5 ABCG8

9.28e-0449733PS00211
DomainABC_transporter-like

ABCG4 ABCB5 ABCG8

9.84e-0450733IPR003439
DomainIon_trans_dom

KCNC1 KCNC3 KCNC4 TRPC3

1.04e-03114734IPR005821
DomainIon_trans

KCNC1 KCNC3 KCNC4 TRPC3

1.04e-03114734PF00520
DomainBTB_2

KCNC1 KCNC3 KCNC4

1.17e-0353733PF02214
DomainT1-type_BTB

KCNC1 KCNC3 KCNC4

1.17e-0353733IPR003131
DomainChannel_four-helix_dom

KCNC1 KCNC3 KCNC4

1.44e-0357733IPR027359
Domain-

KCNC1 KCNC3 KCNC4

1.44e-03577331.20.120.350
DomainMFS_dom

SLC22A16 SLC16A1 FLVCR2 MFSD4B

1.88e-03134734IPR020846
DomainNA_NEUROTRAN_SYMP_2

SLC6A18 SLC6A9

2.21e-0318732PS00754
DomainSNF

SLC6A18 SLC6A9

2.47e-0319732PF00209
DomainNA_NEUROTRAN_SYMP_1

SLC6A18 SLC6A9

2.47e-0319732PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A18 SLC6A9

2.47e-0319732PS50267
DomainNa/ntran_symport

SLC6A18 SLC6A9

2.47e-0319732IPR000175
DomainDAG/PE-bd

RAF1 ARAF

3.02e-0321732IPR020454
DomainMFS_1

SLC16A1 FLVCR2 MFSD4B

3.41e-0377733PF07690
DomainMFS

SLC16A1 FLVCR2 MFSD4B

3.41e-0377733IPR011701
DomainMFS

SLC22A16 SLC16A1 FLVCR2

8.72e-03108733PS50850
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR1F12P OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

1.10e-144176319M4072
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

4.84e-143896318M14091
PathwayREACTOME_SENSORY_PERCEPTION

OR8H3 OR8D1 OR2A7 OR8D2 TMC2 OR5AK2 OR9K2 OR1B1 OR2G6 OR2A4 OR52N5 OR1D5 OR1F12P CDH23 OR3A3 OR5T2 OR2A25 OR8K3 OR1D4 OR1J2 OR6N1

1.85e-136366321M41834
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC5A5 SLC24A5 SLC6A18 RAF1 SLC6A9 ABCG4 ATP13A4 SLC22A16 SLC16A1 ABCB5 TRPC3 MFSD4B ABCG8 TFRC

3.40e-067366314M27287
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

SLC5A5 SLC24A5 SLC6A18 RAF1 SLC6A9 ABCG4 ATP13A4 SLC22A16 SLC16A1 ABCB5 TRPC3 ABCG8 TFRC

7.78e-066816313MM14985
PathwayWP_GPCRS_OTHER

OR8D1 OR2A7 OR2A4 OR1D5 SMO

6.78e-0596635MM15939
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC5A5 SLC24A5 SLC6A18 SLC6A9 SLC22A16 SLC16A1 MFSD4B

1.17e-04249637M5988
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC6A18 SLC6A9 SLC22A16 SLC16A1

3.65e-0476634MM15072
PathwayREACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS

SLC6A18 SLC6A9 SLC22A16 SLC16A1

5.35e-0484634M27334
PathwayREACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS

RAF1 ARAF

5.41e-048632M38999
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE

RAF1 ARAF

5.41e-048632M47933
PathwayREACTOME_GAP_JUNCTION_ASSEMBLY

GJA9 GJA5 GJA10

6.42e-0438633M14981
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC5A5 SLC24A5 SLC6A18 SLC6A9 SLC22A16 SLC16A1

6.61e-04238636MM15076
PathwayWP_GPCRS_OTHER

OR2A4 P2RY13 OR3A3 SMO

7.85e-0493634M39629
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNC1 KCNC3 KCNC4

8.03e-0441633MM14546
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_ERK_SIGNALING_PATHWAY

RAF1 ARAF

8.64e-0410632M47374
PathwayKEGG_MEDICUS_VARIANT_HRAS_OVEREXPRESSION_TO_ERK_SIGNALING_PATHWAY

RAF1 ARAF

8.64e-0410632M47420
PathwayKEGG_MEDICUS_REFERENCE_RAC_CDC42_PAK_ERK_SIGNALING_PATHWAY

RAF1 ARAF

8.64e-0410632M47735
PathwayREACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS

KCNC1 KCNC3 KCNC4

9.24e-0443633M1056
PathwayREACTOME_POTASSIUM_CHANNELS

KCNK18 KCNC1 KCNC3 KCNC4

9.56e-0498634MM14545
PathwayKEGG_ABC_TRANSPORTERS

ABCG4 ABCB5 ABCG8

9.89e-0444633M11911
PathwayREACTOME_SLC_TRANSPORTER_DISORDERS

SLC5A5 SLC24A5 SLC6A18 SLC16A1

9.92e-0499634M27474
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

OR8D2 OR2A4 OR1D5 P2RY13 OR3A3 OR1D4

1.05e-03260636M39397
PathwayKEGG_MEDICUS_VARIANT_RET_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.05e-0311632M47370
PathwayKEGG_MEDICUS_VARIANT_TRK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.05e-0311632M47371
PathwayREACTOME_POTASSIUM_CHANNELS

KCNK18 KCNC1 KCNC3 KCNC4

1.15e-03103634M1073
PathwayREACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS

SLC5A5 SLC24A5 SLC6A18 SLC16A1 ABCG8

1.15e-03177635M27476
PathwayWP_MAPK_AND_NFKB_SIGNALING_INHIBITED_BY_YERSINIA_YOPJ

RAF1 CHUK

1.26e-0312632M39552
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.26e-0312632M47369
PathwayKEGG_MEDICUS_PATHOGEN_HBV_LHBS_TO_PKC_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.26e-0312632M47597
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.26e-0312632M47815
PathwayKEGG_MEDICUS_PATHOGEN_HCV_CORE_TO_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.49e-0313632M47589
PathwayREACTOME_GAP_JUNCTION_TRAFFICKING_AND_REGULATION

GJA9 GJA5 GJA10

1.52e-0351633M26972
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.73e-0314632M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.73e-0314632M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.73e-0314632M47366
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.73e-0314632M47378
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PLCG_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.73e-0314632M47383
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PLCG_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.73e-0314632M47384
PathwayKEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.73e-0314632M47488
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47367
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47375
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PLCG_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47382
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47380
PathwayKEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47592
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47593
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47640
PathwayKEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47485
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47473
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47474
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47495
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47497
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47472
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47535
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

1.99e-0315632M47531
PathwayWP_FRAGILE_X_SYNDROME

RAF1 KCNC1 SLC16A1 ARAF

2.08e-03121634M39804
PathwayKEGG_ACUTE_MYELOID_LEUKEMIA

RAF1 ARAF CHUK

2.10e-0357633M19888
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.27e-0316632M47363
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.27e-0316632M47373
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.27e-0316632M47381
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.27e-0316632M47804
PathwayKEGG_MEDICUS_ENV_FACTOR_E2_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.27e-0316632M47801
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.27e-0316632M47483
PathwayKEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY

RAF1 ARAF

2.27e-0316632M47682
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

2.56e-0317632M47376
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY

RAF1 ARAF

2.56e-0317632M47684
PathwayREACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS

ABCG4 ABCG8

2.56e-0317632MM14552
PathwayWP_INHIBITION_OF_EXOSOME_BIOGENESIS_AND_SECRETION_BY_MANUMYCIN_A_IN_CRPC_CELLS

RAF1 ARAF

2.87e-0318632M39737
PathwayREACTOME_ABC_TRANSPORTERS_IN_LIPID_HOMEOSTASIS

ABCG4 ABCG8

2.87e-0318632M524
PathwayKEGG_MEDICUS_REFERENCE_CXCL12_CXCR4_PKC_ERK_SIGNALING_PATHAWAY

RAF1 ARAF

3.20e-0319632M47596
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

3.20e-0319632M47793
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A18 SLC6A9

3.20e-0319632M27362
PathwayREACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS

SLC6A18 SLC6A9

3.20e-0319632MM15107
PathwayWP_ACUTE_MYELOID_LEUKEMIA

RAF1 ARAF CHUK

3.47e-0368633M48322
PathwayWP_MELANOMA

RAF1 KDR ARAF

3.47e-0368633M39811
PathwayREACTOME_NEURONAL_SYSTEM

CACNG2 KCNK18 KCNC1 KCNC3 KCNC4 GJA10

3.75e-03335636MM14503
PathwayKEGG_PANCREATIC_CANCER

RAF1 ARAF CHUK

3.76e-0370633M9726
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR8D1 OR1D5 OR8K3

3.76e-0370633MM14984
PathwayKEGG_MEDICUS_REFERENCE_ACH_CHRN_RAS_ERK_SIGNALING_PATHWAY

RAF1 ARAF

3.91e-0321632M47792
PathwayBIOCARTA_RAS_PATHWAY

RAF1 CHUK

3.91e-0321632MM1464
PathwayKEGG_CHRONIC_MYELOID_LEUKEMIA

RAF1 ARAF CHUK

4.24e-0373633M321
PathwayBIOCARTA_RAS_PATHWAY

RAF1 CHUK

4.29e-0322632M17294
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2A4 OR52N5 OR1D5 OR1F12P OR5T2 OR2A25 OR8K3 OR6N1

5.66e-16340741511875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2A4 OR52N5 OR1D5 OR1F12P OR5T2 OR2A25 OR8K3 OR6N1

5.66e-16340741511802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2A4 OR52N5 OR1D5 OR1F12P OR5T2 OR2A25 OR8K3 OR6N1

6.45e-16343741532295537
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2A4 OR52N5 OR1D5 OR1F12P OR5T2 OR2A25 OR8K3 OR6N1

7.33e-16346741514611657
Pubmed

The human olfactory receptor gene family.

OR8H3 OR8D1 OR2A7 OR8D2 OR5AK2 OR9K2 OR1B1 OR2A4 OR52N5 OR1D5 OR1F12P OR3A3 OR5T2 OR8K3 OR1D4 OR1J2 OR6N1

1.44e-15541741714983052
Pubmed

Brain expression of Kv3 subunits during development, adulthood and aging and in a murine model of Alzheimer's disease.

KCNC1 KCNC3 KCNC4

3.69e-08474321912965
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNG2 KCNK18 GJA5 KCNC1 KCNC3 KCNC4

5.42e-0713974616985003
Pubmed

Evolution of odorant receptors expressed in mammalian testes.

OR8D1 OR2A7 OR2A4

2.60e-061374311014824
Pubmed

Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles.

KCNC1 KCNC3

4.47e-06274233508244
Pubmed

Kv3 voltage-gated potassium channels regulate neurotransmitter release from mouse motor nerve terminals.

KCNC3 KCNC4

4.47e-06274215610163
Pubmed

Mammalian Ras interacts directly with the serine/threonine kinase Raf.

RAF1 ARAF

4.47e-0627428334704
Pubmed

Ablation of Kv3.1 and Kv3.3 potassium channels disrupts thalamocortical oscillations in vitro and in vivo.

KCNC1 KCNC3

4.47e-06274218495891
Pubmed

Motor dysfunction and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in mice lacking potassium channels Kv3.1 and Kv3.3.

KCNC1 KCNC3

4.47e-06274212930807
Pubmed

Increased motor drive and sleep loss in mice lacking Kv3-type potassium channels.

KCNC1 KCNC3

4.47e-06274215005717
Pubmed

Kv3 potassium channels control the duration of different arousal states by distinct stochastic and clock-like mechanisms.

KCNC1 KCNC3

4.47e-06274216553620
Pubmed

Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse.

KCNC1 KCNC3

4.47e-06274235510987
Pubmed

A-Raf and C-Raf differentially regulate mechanobiological response of osteoblasts to guide mechanical stress-induced differentiation.

RAF1 ARAF

4.47e-06274227240957
Pubmed

Behavioral motor dysfunction in Kv3-type potassium channel-deficient mice.

KCNC1 KCNC3

4.47e-06274216923152
Pubmed

Spinocerebellar ataxia-13 Kv3.3 potassium channels: arginine-to-histidine mutations affect both functional and protein expression on the cell surface.

KCNC1 KCNC3

4.47e-06274223734863
Pubmed

Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus.

DPY19L2 DPY19L2P2

4.47e-06274222764053
Pubmed

Subcellular localization of the voltage-gated potassium channels Kv3.1b and Kv3.3 in the cerebellar dentate nucleus of glutamic acid decarboxylase 67-green fluorescent protein transgenic mice.

KCNC1 KCNC3

4.47e-06274218682278
Pubmed

Rescue of motor coordination by Purkinje cell-targeted restoration of Kv3.3 channels in Kcnc3-null mice requires Kcnc1.

KCNC1 KCNC3

4.47e-06274220016089
Pubmed

Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants.

KCNC1 KCNC3

4.47e-06274218448641
Pubmed

Allele-dependent changes of olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3.

KCNC1 KCNC3

4.47e-06274215217387
Pubmed

A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression.

RAF1 ARAF

4.47e-06274215856007
Pubmed

Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3.

KCNC1 KCNC3

4.47e-06274211517255
Pubmed

Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development.

DPY19L2 DPY19L2P2

4.47e-06274225354700
Pubmed

Subcellular localization of phospholipase Cζ in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation.

DPY19L2 DPY19L2P2

4.47e-06274225354701
Pubmed

Sequence, structure, and evolution of a complete human olfactory receptor gene cluster.

OR1D5 OR3A3 OR1D4

5.08e-061674310673334
Pubmed

DEFOG: a practical scheme for deciphering families of genes.

OR2A7 OR1D5 OR3A3 OR1D4 OR1J2 OR6N1

7.55e-0621974612213199
Pubmed

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

RAF1 ARAF

1.34e-05374220130576
Pubmed

Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons.

KCNC1 KCNC3

1.34e-05374222673617
Pubmed

Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope.

DPY19L2 DPY19L2P2

1.34e-05374225775128
Pubmed

Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.

RAF1 ARAF

1.34e-05374214688025
Pubmed

Expression of raf family proto-oncogenes in normal mouse tissues.

RAF1 ARAF

1.34e-0537421690378
Pubmed

Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation.

RAF1 ARAF

1.34e-05374220052757
Pubmed

Endothelial apoptosis in Braf-deficient mice.

RAF1 ARAF

1.34e-0537429207797
Pubmed

Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1.

KCNC3 KCNC4

1.34e-0537421740329
Pubmed

Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.

RAF1 ARAF

1.34e-05374223352452
Pubmed

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis.

RAF1 ARAF

1.34e-05374210704835
Pubmed

Hedgehog signaling is essential for endothelial tube formation during vasculogenesis.

KDR SMO

1.34e-05374215294868
Pubmed

Duplication and relocation of the functional DPY19L2 gene within low copy repeats.

DPY19L2 DPY19L2P2

1.34e-05374216526957
Pubmed

ARAF acts as a scaffold to stabilize BRAF:CRAF heterodimers.

RAF1 ARAF

1.34e-05374222926515
Pubmed

Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.

OR2A7 OR2A4

1.34e-05374227315375
Pubmed

Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase by G protein and tyrosine kinase oncoproteins.

RAF1 ARAF

2.67e-0547428394352
Pubmed

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels.

TMC2 PIEZO1

2.67e-05474227893727
Pubmed

Identification of interaction between MEK2 and A-Raf-1.

RAF1 ARAF

2.67e-05474211909642
Pubmed

Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.

RAF1 ARAF

2.67e-0547428621729
Pubmed

Aberrant expression of COT is related to recurrence of papillary thyroid cancer.

RAF1 ARAF

2.67e-05474225674762
Pubmed

A zonal organization of odorant receptor gene expression in the olfactory epithelium.

OR2A7 OR2A4

2.67e-0547427683976
Pubmed

Sensory transduction is required for normal development and maturation of cochlear inner hair cell synapses.

TMC2 CDH23

2.67e-05474234734805
Pubmed

Expression of connexin genes in the human retina.

GJA9 GJA10

2.67e-05474220979653
Pubmed

B-Raf protein isoforms interact with and phosphorylate Mek-1 on serine residues 218 and 222.

RAF1 ARAF

2.67e-0547427731720
Pubmed

Alpha-interferon and its effects on signal transduction pathways.

CHUK IFNAR2

2.67e-05474215389589
Pubmed

Functional characterization of a PROTAC directed against BRAF mutant V600E.

RAF1 ARAF

2.67e-05474232778845
Pubmed

Localization of Shaw-related K+ channel genes on mouse and human chromosomes.

KCNC1 KCNC3

2.67e-0547428111118
Pubmed

Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin.

PIEZO1 KDR

2.67e-05474237117774
Pubmed

Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels.

GJA5 KDR SMO

3.98e-053174322076636
Pubmed

Voltage-gated potassium channel genes are clustered in paralogous regions of the mouse genome.

RAF1 KCNC4 ARAF

3.98e-05317438034307
Pubmed

FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice.

DPY19L2 DPY19L2P2

4.45e-05574234471926
Pubmed

Rapid State-Dependent Alteration in Kv3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization.

KCNC1 KCNC4

4.45e-05574228228266
Pubmed

TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling.

CHUK TFRC

4.45e-05574223016877
Pubmed

Germline gain-of-function mutations in RAF1 cause Noonan syndrome.

RAF1 ARAF

4.45e-05574217603482
Pubmed

Expression and functional characterization of ABCG1 splice variant ABCG1(666).

ABCG4 ABCG8

4.45e-05574216870176
Pubmed

In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knock-out mice.

RAF1 ARAF

4.45e-05574217219248
Pubmed

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors.

RAF1 ARAF

4.45e-05574224746704
Pubmed

A probabilistic classifier for olfactory receptor pseudogenes.

OR8D2 OR1B1 OR8K3

5.76e-053574316939646
Pubmed

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

RAF1 ARAF

6.66e-0567428157000
Pubmed

Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues.

GJA9 GJA10

6.66e-05674212881038
Pubmed

Specification of the mouse cardiac conduction system in the absence of Endothelin signaling.

GJA5 KDR

6.66e-05674225050930
Pubmed

Isoform-specific localization of A-RAF in mitochondria.

RAF1 ARAF

6.66e-05674210848612
Pubmed

Ion channel expression in the developing enteric nervous system.

CACNG2 KCNC1 KCNC4

6.82e-053774325798587
Pubmed

Personal receptor repertoires: olfaction as a model.

OR8D2 OR1B1 OR8K3

7.39e-053874322908908
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

SLC5A5 SLC6A9 SLC16A1 TFRC

7.67e-0510574430280653
Pubmed

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

KCNC1 KCNC3 KCNC4

8.63e-054074316382104
Pubmed

Identification of Nore1 as a potential Ras effector.

RAF1 ARAF

9.31e-0577429488663
Pubmed

Endothelial RAF1/ERK activation regulates arterial morphogenesis.

RAF1 GJA5

9.31e-05774223529931
Pubmed

Hedgehog signaling in the posterior region of the mouse gastrula suggests manifold roles in the fetal-umbilical connection and posterior morphogenesis.

KDR SMO

9.31e-05774222016185
Pubmed

Functional significance of gap junctional coupling in preimplantation development.

GJA5 GJA10

9.31e-05774211967204
Pubmed

Saturation mutagenesis defines novel mouse models of severe spine deformity.

OR2A7 OR2A4

1.24e-04874234142127
Pubmed

Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization.

RAF1 GJA5

1.24e-0487421376319
Pubmed

Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice.

GJA5 KDR

1.24e-04874226253403
Pubmed

Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch.

RAF1 CHUK

1.24e-04874220442316
Pubmed

Nkx2-5 suppresses the proliferation of atrial myocytes and conduction system.

GJA5 KDR

1.24e-04874224563458
Pubmed

The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell.

TMC2 PIEZO1

1.24e-04874238228630
Pubmed

FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network.

KDR SMO

1.24e-04874217881491
Pubmed

FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development.

GJA5 KDR

1.24e-04874222411556
Pubmed

Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.

RAF1 ARAF

1.59e-04974219667065
Pubmed

AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.

RAF1 ARAF

1.59e-04974230595535
Pubmed

A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes.

RAF1 ARAF

1.59e-04974217967876
Pubmed

Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein.

RAF1 ARAF

1.59e-04974211969417
Pubmed

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4.

KDR SMO

1.59e-04974217881493
Pubmed

Hedgehog is required for murine yolk sac angiogenesis.

KDR SMO

1.59e-04974211807029
Pubmed

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.

SLC5A5 C8B TFRC

1.69e-045074324769233
Pubmed

Establishment and Dysfunction of the Blood-Brain Barrier.

SLC6A9 SLC16A1 TFRC

1.90e-045274326590417
Pubmed

Essential role of B-Raf in ERK activation during extraembryonic development.

RAF1 ARAF

1.99e-041074216432225
Pubmed

Reconstitution of the embryonic kidney identifies a donor cell contribution to the renal vasculature upon transplantation.

GJA5 KDR

1.99e-041074230718617
Pubmed

Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth.

GJA5 KDR

1.99e-041074226897025
Pubmed

Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo.

KDR SMO

1.99e-041074211311154
Pubmed

Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells.

GJA5 KDR

1.99e-041074215977181
Cytoband11q12.1

OR8H3 OR5AK2 OR5T2 OR8K3

1.38e-0416174411q12.1
Cytoband17p13.3

OR1D5 OR3A3 OR1D4

4.00e-048874317p13.3
CytobandEnsembl 112 genes in cytogenetic band chr11q12

OR8H3 OR5AK2 OR5T2 OR8K3

2.38e-03345744chr11q12
CytobandEnsembl 112 genes in cytogenetic band chr17p13

OR1D5 OR3A3 OR1D4 NEURL4

2.41e-03346744chr17p13
Cytoband10q22.1

CDH23 MACROH2A2

2.53e-034674210q22.1
Cytoband12q13.2

OR9K2 PAN2

3.60e-035574212q13.2
Cytoband7q35

OR2A7 OR2A25

3.60e-03557427q35
Cytoband11q24.2

OR8D1 OR8D2

4.70e-036374211q24.2
CytobandEnsembl 112 genes in cytogenetic band chr7q35

OR2A7 OR2A25

5.14e-0366742chr7q35
GeneFamilyOlfactory receptors, family 1

OR1B1 OR1D5 OR1F12P OR1D4 OR1J2

1.44e-0740565147
GeneFamilyOlfactory receptors, family 8

OR8H3 OR8D1 OR8D2 OR8K3

1.58e-0549564155
GeneFamilyGap junction proteins

GJA9 GJA5 GJA10

4.16e-0522563314
GeneFamilyBlood group antigens|CD molecules|ATP binding cassette subfamily G

ABCG4 ABCG8

9.37e-055562811
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

RAF1 ARAF

9.37e-0555621157
GeneFamilySolute carriers

SLC5A5 SLC24A5 SLC6A18 SLC6A9 SLC22A16 SLC16A1 FLVCR2

2.08e-04395567752
GeneFamilyPotassium voltage-gated channels

KCNC1 KCNC3 KCNC4

2.56e-0440563274
GeneFamilyOlfactory receptors, family 2

OR2A7 OR2G6 OR2A4 OR2A25

4.14e-04113564149
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

RAF1 ARAF

2.49e-0324562654
ToppCellfacs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A9 ABCG4 SLC16A1 BACE2 TFRC

8.95e-0616874517fb9426eeea407b26fb895b8397faca95b7552d
ToppCellfacs-Marrow-B-cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC6A9 ABCG4 SLC16A1 BACE2 TFRC

8.95e-06168745a61b39884851384cffd430079040546d125b2b40
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNG2 KCNC1 KCNC3 KCNC4 TRPC3

1.54e-051887451efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellControl_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega|Control_saline / Treatment groups by lineage, cell group, cell type

SLC6A9 SLC22A16 SLC16A1 BACE2 TFRC

1.98e-051987451a39a98beef68e1e6d3adc25270a3336fcc5baf4
ToppCellControl_saline-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid|Control_saline / Treatment groups by lineage, cell group, cell type

SLC6A9 SLC22A16 SLC16A1 BACE2 TFRC

1.98e-05198745dd80fd9671ee863aebcf4c1023d3e004cc2ee709
ToppCellControl_saline-Hematopoietic_Erythro-Megakary|Control_saline / Treatment groups by lineage, cell group, cell type

SLC6A9 SLC22A16 SLC16A1 BACE2 TFRC

1.98e-05198745cfc2a860bae883299987d3e374d0476ca20e1bdd
Diseasepulse pressure measurement, anxiety

GJA9 GJA10

1.06e-047672EFO_0005230, EFO_0005763
DiseaseMalignant Glioma

SLC5A5 RAF1 TFRC

5.49e-0470673C0555198
Diseasemixed gliomas

SLC5A5 RAF1 TFRC

5.49e-0470673C0259783
DiseaseGlioma

SLC5A5 RAF1 TFRC

1.03e-0387673C0017638
DiseaseEpilepsy, Benign Psychomotor, Childhood

KCNC4 KDR

1.25e-0323672C0393672
DiseaseEpilepsy, Lateral Temporal

KCNC4 KDR

1.25e-0323672C0393682
DiseaseUncinate Epilepsy

KCNC4 KDR

1.25e-0323672C0014558
DiseaseEpilepsy, Temporal Lobe

KCNC4 KDR

1.25e-0323672C0014556
Diseasesuicidal ideation

AREL1 CDH23

1.98e-0329672EFO_0004320
Diseasecuneus cortex volume measurement

GJA9 GJA10

2.26e-0331672EFO_0010301

Protein segments in the cluster

PeptideGeneStartEntry
VRYGFEGVILTIYGM

ABCG4

571

Q9H172
VIGATVMEGFYVIFD

BACE2

406

Q9Y5Z0
IGMIYTLCVYVLSGE

ATP13A4

411

Q4VNC1
EDMTLLTLYYVGIGV

ABCB5

101

Q2M3G0
VLEVGFMIGQYILYG

GJA10

166

Q969M2
VYLVMEYLIGGDVKS

MASTL

106

Q96GX5
ISVGAPVYMAAVIEY

MACROH2A2

41

Q9P0M6
VVFGLLLSYVMSGYR

CDS2

271

O95674
IVIGLSGGFMVLYYV

ABCG8

646

Q9H221
FGITYYMERILEGAT

CDH23

2296

Q9H251
VYSYGIVLYELMTGE

RAF1

531

P04049
VFVVAEGYLLTAMAY

OR8D1

106

Q8WZ84
YFGALSFIIAEMVGV

CACNG2

181

Q9Y698
GVVSVLYGAVFFMYL

OR9K2

271

Q8NGE7
IISGIYLFIGMGINY

SLC16A1

431

P53985
GVYVYDLMATVVHIL

PAN2

846

Q504Q3
TVVLIFYGSILSMYV

OR6N1

246

Q8NGY5
LTMVGFLYGTIICVY

OR1B1

251

Q8NGR6
FMCILVSYGYIGATI

OR1J2

211

Q8NGS2
ALVILFYGAITGVYM

OR1F12P

246

Q8NHA8
IFVIAEGYLLTAMEY

OR8D2

106

Q9GZM6
SIYIIVGMEIVFIAF

KCNK18

341

Q7Z418
YAEVGVIGYLEDQIM

CHUK

521

O15111
VVGIFYGTGVFSYMR

OR3A3

256

P47888
VIGLFYGTAIIMYVG

OR2A7

246

Q96R45
QIASLFPMYVVGYIE

DPY19L2

351

Q6NUT2
EIIMFVAGFLEGYLT

PLBD1

96

Q6P4A8
YAVIGTYMFLVSVIF

MFSD4B

186

Q5TF39
LGVTIFYGTMIFTYL

OR8H3

246

Q8N146
VVLLMGLVFASVYIY

ITM2C

66

Q9NQX7
VLMVYISLVFGISYD

IFNAR2

16

P48551
VIGLVYGTAIIMYVG

OR2A4

246

O95047
VIFYETMYVGIVLLG

P2RY13

121

Q9BPV8
GLVVIFSYIYIMATI

OR5AK2

211

Q8NH90
SPVEFMGYLYFVGTI

PORCN

151

Q9H237
DVYAYGVVLYELMTG

ARAF

491

P10398
VLIFATMIYYAERIG

KCNC1

356

P48547
VVEVGFMIGQYLLYG

GJA9

166

P57773
TTMEVGFIVGQYFIY

GJA5

161

P36382
MFYVIGGITVSVVAF

AREL1

1

O15033
VVMIIIFGYSAIYGY

ATRNL1

426

Q5VV63
LAYHISIMFYIIGGV

FLVCR2

246

Q9UPI3
MIYYLVVGVTVSAGG

MGARP

46

Q8TDB4
TEAVLGGIYEYTLVM

C8B

346

P07358
VYGVVDLYGMAVKVT

NEURL4

466

Q96JN8
QIASLFPMYVVGYIE

DPY19L2P2

161

Q6ZN68
VVGLFYGTAIIMYVE

OR2A25

246

A4D2G3
TMYIIFLVGNLGLVY

OR52N5

41

Q8NH56
GVVSLFYGTLAMVYL

OR1D4

246

P47884
GVVSLFYGTLAMVYL

OR1D5

246

P58170
VVVIIFYGTIIFMYL

OR2G6

246

Q5TZ20
QGMEYLLGVVEVYRV

SYNRG

1166

Q9UMZ2
AMVASGYLVVGFVYV

SLC22A16

216

Q86VW1
GYLVVGFVYVMEFIG

SLC22A16

221

Q86VW1
IYYLAKMYATGTGVV

SEL1L2

446

Q5TEA6
VVIVFYGTLLFMYVQ

OR8K3

246

Q8NH51
GVSIYYGTILFMYVR

OR5T2

286

Q8NGG2
IAVIVFFLIGFMIGY

TFRC

71

P02786
LVSIVGMALYTGYVF

SPTSSA

41

Q969W0
LMLAFLEVVGVVYVY

SLC6A18

481

Q96N87
TAYGVDFLVPVMGYI

CIZ1

786

Q9ULV3
VYDAVGMLGIEEVTY

NLN

71

Q9BYT8
EEIIYNMVVGIIYIF

XKR7

356

Q5GH72
TVEGVYDYLMYVGRV

SNX14

786

Q9Y5W7
QYIVATMLYTGIVIY

SLC5A5

136

Q92911
DGGIIIYFLIIVYMF

SLC24A5

66

Q71RS6
MVVSTYIGIYYNVVI

SLC6A9

186

P48067
LIYKISYATGIVGYM

RNF121

141

Q9H920
IIFVIVYYALMAGVV

SMO

316

Q99835
SIMYIVVVVGYRIYD

KDR

211

P35968
AGYGIMGLYVSIVLV

PIEZO1

2436

Q92508
YFMVGVSVFGYSLII

TMC2

341

Q8TDI7
YVLYGIYNVTMVVVL

TRPC3

636

Q13507
ALGVLIFATMIYYAE

KCNC3

456

Q14003
GVLIFATMIYYAERI

KCNC4

391

Q03721