Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	TBC1D3H TBC1D3L TBC1D3D ITGB1BP1 DENND2B TBC1D3B RGS7 DLC1 TIAM1 ARHGEF1 ARHGAP29 RIMS1 TBC1D3I TBC1D3G PLCE1	7.41e-07	507	126	15	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	TBC1D3H TBC1D3L TBC1D3D ITGB1BP1 DENND2B TBC1D3B RGS7 DLC1 TIAM1 ARHGEF1 ARHGAP29 RIMS1 TBC1D3I TBC1D3G PLCE1	7.41e-07	507	126	15	GO:0030695
GeneOntologyMolecularFunction	GTPase activator activity	TBC1D3H TBC1D3L TBC1D3D TBC1D3B RGS7 DLC1 ARHGEF1 ARHGAP29 TBC1D3I TBC1D3G	1.12e-05	279	126	10	GO:0005096
GeneOntologyMolecularFunction	enzyme regulator activity	TBC1D3H TBC1D3L TBC1D3D ITGB1BP1 TOPBP1 DENND2B TBC1D3B RGS7 IBTK THADA DLC1 TIAM1 CCNB3 ARHGEF1 ARHGAP29 AKAP11 RIMS1 BSN TBC1D3I TBC1D3G TP53 PLCE1 FBXW7	2.45e-05	1418	126	23	GO:0030234
GeneOntologyMolecularFunction	structural constituent of chromatin	H3-5 H3-4 H3-7 H3C15 H3C1 H3-3A	4.11e-05	100	126	6	GO:0030527
GeneOntologyBiologicalProcess	activation of GTPase activity	TBC1D3H TBC1D3L TBC1D3D TBC1D3B TIAM1 ARHGAP29 TBC1D3I TBC1D3G	2.57e-07	109	121	8	GO:0090630
GeneOntologyBiologicalProcess	nucleosome assembly	ATRX H3-4 H3C15 H3C1 SUPT16H H3-3A SPTY2D1	7.70e-06	122	121	7	GO:0006334
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	TBC1D3H TBC1D3L TBC1D3D TBC1D3B RGS7 TIAM1 ARHGAP29 TBC1D3I TBC1D3G	1.40e-05	244	121	9	GO:0043547
GeneOntologyBiologicalProcess	protein-DNA complex assembly	ATRX H3-4 H3C15 MED15 H3C1 SUPT16H H3-3A SPTY2D1 TP53	1.64e-05	249	121	9	GO:0065004
GeneOntologyBiologicalProcess	nucleosome organization	ATRX H3-4 H3C15 H3C1 SUPT16H H3-3A SPTY2D1	2.08e-05	142	121	7	GO:0034728
GeneOntologyBiologicalProcess	regulation of GTPase activity	TBC1D3H TBC1D3L TBC1D3D ITGB1BP1 TBC1D3B RGS7 TIAM1 ARHGAP29 TBC1D3I TBC1D3G	2.87e-05	335	121	10	GO:0043087
GeneOntologyCellularComponent	cytoskeleton of presynaptic active zone	RIMS3 RIMS1 BSN	1.17e-05	8	126	3	GO:0048788
GeneOntologyCellularComponent	presynaptic cytoskeleton	RIMS3 RIMS1 BSN	7.41e-05	14	126	3	GO:0099569
GeneOntologyCellularComponent	nucleosome	H3-5 H3-4 H3-7 H3C15 H3C1 H3-3A	1.91e-04	138	126	6	GO:0000786
GeneOntologyCellularComponent	presynaptic active zone cytoplasmic component	RIMS3 RIMS1 BSN	3.47e-04	23	126	3	GO:0098831
GeneOntologyCellularComponent	chromosome, telomeric region	SETX ATRX H3-4 BRCA2 NAT10 H3-3A	7.00e-04	176	126	6	GO:0000781
Domain	HISTONE_H3_1	H3-5 H3-4 H3C1 H3-3A	6.59e-08	7	125	4	PS00322
Domain	HISTONE_H3_2	H3-5 H3-4 H3C1 H3-3A	1.31e-07	8	125	4	PS00959
Domain	Histone_H3/CENP-A	H3-5 H3-4 H3C1 H3-3A	1.31e-07	8	125	4	IPR000164
Domain	H3	H3-5 H3-4 H3C1 H3-3A	1.31e-07	8	125	4	SM00428
Domain	TBC	TBC1D3H TBC1D3L TBC1D3D TBC1D3B TBC1D3I TBC1D3G	8.80e-07	49	125	6	SM00164
Domain	RabGAP-TBC	TBC1D3H TBC1D3L TBC1D3D TBC1D3B TBC1D3I TBC1D3G	1.41e-06	53	125	6	PF00566
Domain	Rab-GTPase-TBC_dom	TBC1D3H TBC1D3L TBC1D3D TBC1D3B TBC1D3I TBC1D3G	1.77e-06	55	125	6	IPR000195
Domain	TBC_RABGAP	TBC1D3H TBC1D3L TBC1D3D TBC1D3B TBC1D3I TBC1D3G	1.77e-06	55	125	6	PS50086
Domain	FAM21	WASHC2C WASHC2A	4.44e-05	2	125	2	IPR027308
Domain	P53	TP63 TP53	1.33e-04	3	125	2	PF00870
Domain	P53	TP63 TP53	1.33e-04	3	125	2	PS00348
Domain	p53_DNA-bd	TP63 TP53	1.33e-04	3	125	2	IPR011615
Domain	p53_tetrameristn	TP63 TP53	1.33e-04	3	125	2	IPR010991
Domain	CAP-ZIP_m	WASHC2C WASHC2A	1.33e-04	3	125	2	PF15255
Domain	p53_tumour_suppressor	TP63 TP53	1.33e-04	3	125	2	IPR002117
Domain	-	TP63 TP53	1.33e-04	3	125	2	4.10.170.10
Domain	FAM21/CAPZIP	WASHC2C WASHC2A	1.33e-04	3	125	2	IPR029341
Domain	P53_tetramer	TP63 TP53	1.33e-04	3	125	2	PF07710
Domain	Histone_H2A/H2B/H3	H3-5 H3-4 H3C1 H3-3A	5.37e-04	56	125	4	IPR007125
Domain	Histone	H3-5 H3-4 H3C1 H3-3A	5.37e-04	56	125	4	PF00125
Domain	p53/RUNT-type_TF_DNA-bd	TP63 TP53	6.55e-04	6	125	2	IPR012346
Domain	-	TP63 TP53	6.55e-04	6	125	2	2.60.40.720
Domain	-	H3-5 H3-4 H3C1 H3-3A	1.18e-03	69	125	4	1.10.20.10
Domain	Histone-fold	H3-5 H3-4 H3C1 H3-3A	2.34e-03	83	125	4	IPR009072
Domain	RABBD	EXPH5 RIMS1	2.81e-03	12	125	2	PS50916
Domain	Rab_BD	EXPH5 RIMS1	2.81e-03	12	125	2	IPR010911
Domain	NPIP	NPIPB8 NPIPB6	3.84e-03	14	125	2	IPR009443
Domain	EF-hand_like	PLCH1 PLCE1	4.41e-03	15	125	2	PF09279
Domain	PI-PLC-Y	PLCH1 PLCE1	4.41e-03	15	125	2	PF00387
Domain	PLCYc	PLCH1 PLCE1	4.41e-03	15	125	2	SM00149
Domain	PLipase_C_Pinositol-sp_Y	PLCH1 PLCE1	4.41e-03	15	125	2	IPR001711
Domain	PIPLC_Y_DOMAIN	PLCH1 PLCE1	4.41e-03	15	125	2	PS50008
Domain	PI-PLC_fam	PLCH1 PLCE1	4.41e-03	15	125	2	IPR001192
Domain	PLC_EF-hand-like	PLCH1 PLCE1	4.41e-03	15	125	2	IPR015359
Domain	PI-PLC-X	PLCH1 PLCE1	6.34e-03	18	125	2	PF00388
Domain	PLCXc	PLCH1 PLCE1	6.34e-03	18	125	2	SM00148
Pathway	KEGG_MEDICUS_VARIANT_IGH_MMSET_FUSION_TO_TRANSCRIPTIONAL_ACTIVATION	H3-5 H3-4 H3C15 H3C1 H3-3A	8.66e-08	19	87	5	M47442
Pathway	WP_EFFECT_OF_PROGERIN_ON_GENES_INVOLVED_IN_PROGERIA	H3C15 H3C1 H3-3A TP53	7.65e-05	37	87	4	M39756
Pathway	REACTOME_CONDENSATION_OF_PROPHASE_CHROMOSOMES	PHF8 H3-4 H3C15 H3C1 H3-3A	8.61e-05	73	87	5	M27166
Pathway	REACTOME_MEIOTIC_RECOMBINATION	H3-4 H3C15 H3C1 BRCA2 H3-3A	2.09e-04	88	87	5	M1011
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3H TBC1D3L TBC1D3D TBC1D3B TBC1D3I TBC1D3G	1.16e-12	11	131	6	16863688
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SETX H3-5 ATRX ZNF280C TOPBP1 LARP1 GPATCH4 H3-4 CWC22 H3C15 H3C1 BRCA2 NAT10 STAU2 SUPT16H H3-3A BOD1L1 AFF4 TP53 SYNCRIP	5.35e-10	954	131	20	36373674
Pubmed	Crystal structure of DPF3b in complex with an acetylated histone peptide.	H3-5 H3-4 H3C1 H3-3A	2.39e-08	9	131	4	27402533
Pubmed	Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.	H3-7 H3C15 H3C1 H3-3A	6.22e-08	11	131	4	15471871
Pubmed	Human PAD4 regulates histone arginine methylation levels via demethylimination.	H3-4 H3-7 H3C15 H3-3A	6.22e-08	11	131	4	15345777
Pubmed	Expression patterns and post-translational modifications associated with mammalian histone H3 variants.	H3-7 H3C15 H3C1 H3-3A	1.87e-07	14	131	4	16267050
Pubmed	Viral reprogramming of the Daxx histone H3.3 chaperone during early Epstein-Barr virus infection.	ATRX H3C1 H3-3A	2.08e-07	4	131	3	25275136
Pubmed	A standardized nomenclature for mammalian histone genes.	H3-5 H3-4 H3-7 H3C15 H3C1 H3-3A	3.82e-07	74	131	6	36180920
Pubmed	Human spleen histone H3. Isolation and amino acid sequence.	H3-7 H3C15 H3-3A	5.19e-07	5	131	3	7309716
Pubmed	Modifications of human histone H3 variants during mitosis.	H3-7 H3C15 H3-3A	5.19e-07	5	131	3	16185088
Pubmed	FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.	IL16 CYP26A1 NEB TOB1 BRCA2	5.34e-07	42	131	5	29348145
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	ZNF280C GPATCH4 NGDN MSH6 NAT10 STAU2 SUPT16H TP53 MOV10 SYNCRIP	5.40e-07	330	131	10	33301849
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SETX ATRX ZNF280C TOPBP1 GPATCH4 PHF8 MSH6 NAT10 SUPT16H H3-3A BOD1L1 TIMELESS AFF4	5.54e-07	608	131	13	36089195
Pubmed	Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.	ATRX LARP1 H3C15 NGDN H3C1 NAT10 SUPT16H H3-3A	6.16e-07	188	131	8	29721183
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SETX ZNF280C TOPBP1 LARP1 CWC22 IBTK NAT10 MED12L AKAP11 DIXDC1 BSN ZNF646	8.35e-07	529	131	12	14621295
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	ATRX LARP1 GPATCH4 NGDN MSH6 NAT10 STAU2 SUPT16H MOV10 ZNF646	8.97e-07	349	131	10	25665578
Pubmed	Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation.	H3-7 H3C15 H3-3A	1.04e-06	6	131	3	10464286
Pubmed	Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.	H3-7 H3C15 H3-3A	1.04e-06	6	131	3	15525939
Pubmed	Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase.	H3-7 H3C15 H3-3A	1.04e-06	6	131	3	12560483
Pubmed	Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification.	H3-7 H3C15 H3-3A	1.04e-06	6	131	3	17189264
Pubmed	Organismal differences in post-translational modifications in histones H3 and H4.	H3-7 H3C15 H3-3A	1.04e-06	6	131	3	17194708
Pubmed	Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.	H3-7 H3C15 H3C1 H3-3A	1.09e-06	21	131	4	11242053
Pubmed	Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.	H3-7 H3C15 H3-3A	1.81e-06	7	131	3	15684425
Pubmed	PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity.	H3-4 H3C1 H3-3A	1.81e-06	7	131	3	20448663
Pubmed	Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17.	H3-7 H3C15 H3-3A	1.81e-06	7	131	3	16497732
Pubmed	Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation.	H3-7 H3C15 H3-3A	1.81e-06	7	131	3	11856369
Pubmed	The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.	H3-7 H3C15 H3-3A	1.81e-06	7	131	3	15681610
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ATRX TOPBP1 PHF8 MSH6 BRCA2 SUPT16H SPTY2D1 AFF4	2.14e-06	222	131	8	37071664
Pubmed	p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.	TP63 SUPT16H TP53	2.88e-06	8	131	3	12393879
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	ZNF355P SETX WASHC2C ATRX ZNF652 PTPN23 WASHC2A ARHGEF1 NAT10 VPS35L BOD1L1 TIMELESS ASXL2 DTX2 SPTY2D1 AFF4	3.44e-06	1084	131	16	11544199
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	IL16 ARRDC4 GPATCH2 GPATCH4 PHF8 MSH6 INTS6 THADA CCNB3 VANGL1 NAT10 SUPT16H H3-3A AFF4 TP53 ZNF646	4.96e-06	1116	131	16	31753913
Pubmed	RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.	H3-4 H3C15 NGDN MSH6 H3C1 NAT10 STAU2 SUPT16H H3-3A SYNCRIP	5.18e-06	425	131	10	21081503
Pubmed	Human tNASP promotes in vitro nucleosome assembly with histone H3.3.	H3-4 H3C15 H3C1 H3-3A	5.59e-06	31	131	4	25615412
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	ATRX PHF8 CWC22 ZFX MED15 MSH6 H3C1 NAT10 SUPT16H PLCH1 TP53	5.99e-06	533	131	11	30554943
Pubmed	TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.	TOPBP1 TP63 TP53	6.15e-06	10	131	3	21930790
Pubmed	PP1α, PP1β and Wip-1 regulate H4S47 phosphorylation and deposition of histone H3 variant H3.3.	PPM1D H3C1 H3-3A	6.15e-06	10	131	3	23828041
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	TOPBP1 LARP1 GPATCH4 PHF8 NGDN MSH6 IBTK NAT10 STAU2 SUPT16H SPTY2D1 MOV10 SYNCRIP	6.30e-06	759	131	13	35915203
Pubmed	Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.	TOPBP1 MSH6 BRCA2	1.12e-05	12	131	3	16391231
Pubmed	Mutation of ARHGAP9 in patients with coronary spastic angina.	DLC1 TIAM1 ARHGEF1 ARHGAP29	1.28e-05	38	131	4	19911011
Pubmed	Family matters: sibling rivalry and bonding between p53 and p63 in cancer.	TP63 TP53	1.41e-05	2	131	2	24690037
Pubmed	A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation.	TP63 TP53	1.41e-05	2	131	2	29371679
Pubmed	TAp63 plays compensatory roles in p53-deficient cancer cells under genotoxic stress.	TP63 TP53	1.41e-05	2	131	2	21075072
Pubmed	ROLE OF Wip1-p53 AXIS IN RESPONSE OF MURINE CELLS TO TREATMENT WITH SODIUM BUTYRATE AND MEK/ERK SIGNALLING PATHWAY INHIBITOR.	PPM1D TP53	1.41e-05	2	131	2	30188093
Pubmed	Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis.	PPM1D TP53	1.41e-05	2	131	2	23256545
Pubmed	Disrupting PHF8-TOPBP1 connection elicits a breast tumor-specific vulnerability to chemotherapeutics.	TOPBP1 PHF8	1.41e-05	2	131	2	35051531
Pubmed	Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling.	ATRX TP53	1.41e-05	2	131	2	29535300
Pubmed	The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior.	TP63 TP53	1.41e-05	2	131	2	26203771
Pubmed	The p53-homologue p63 may promote thyroid cancer progression.	TP63 TP53	1.41e-05	2	131	2	16322335
Pubmed	NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma.	NKD2 TP53	1.41e-05	2	131	2	25579177
Pubmed	Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).	WASHC2C WASHC2A	1.41e-05	2	131	2	20827171
Pubmed	Minor role for BRCA2 (exon11) and p53 (exon 5-9) among Sudanese breast cancer patients.	BRCA2 TP53	1.41e-05	2	131	2	11883440
Pubmed	FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.	WASHC2C WASHC2A	1.41e-05	2	131	2	36717248
Pubmed	The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9.	ATRX H3C1	1.41e-05	2	131	2	21421568
Pubmed	Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.	BRCA2 TP53	1.41e-05	2	131	2	20421506
Pubmed	p63 and p53 expression in extranodal NK/T cell lymphoma, nasal type.	TP63 TP53	1.41e-05	2	131	2	23626008
Pubmed	Common genetic variants of TP53 and BRCA2 in esophageal cancer patients and healthy individuals from low and high risk areas of northern China.	BRCA2 TP53	1.41e-05	2	131	2	12670525
Pubmed	Down-regulation of wild-type p53-induced phosphatase 1 (Wip1) plays a critical role in regulating several p53-dependent functions in premature senescent tumor cells.	PPM1D TP53	1.41e-05	2	131	2	23612976
Pubmed	Dissecting the DNA binding landscape and gene regulatory network of p63 and p53.	TP63 TP53	1.41e-05	2	131	2	33263276
Pubmed	Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas.	TP63 TP53	1.41e-05	2	131	2	22855598
Pubmed	p63 protects the female germ line during meiotic arrest.	TP63 TP53	1.41e-05	2	131	2	17122775
Pubmed	Spontaneous and irradiation-induced tumor susceptibility in BRCA2 germline mutant mice and cooperative effects with a p53 germline mutation.	BRCA2 TP53	1.41e-05	2	131	2	16546942
Pubmed	p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases.	TP53 FBXW7	1.41e-05	2	131	2	19366810
Pubmed	Mice lacking a transcriptional corepressor Tob are predisposed to cancer.	TOB1 TP53	1.41e-05	2	131	2	12756225
Pubmed	Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.	BRCA2 TP53	1.41e-05	2	131	2	15026330
Pubmed	Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene.	TP53 FBXW7	1.41e-05	2	131	2	15592418
Pubmed	Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.	PPM1D TP53	1.41e-05	2	131	2	32927737
Pubmed	A haplotype containing the p53 polymorphisms Ins16bp and Arg72Pro modifies cancer risk in BRCA2 mutation carriers.	BRCA2 TP53	1.41e-05	2	131	2	16419081
Pubmed	Brca2 and Trp53 deficiency cooperate in the progression of mouse prostate tumourigenesis.	BRCA2 TP53	1.41e-05	2	131	2	20585617
Pubmed	Abrogation of FBW7α-dependent p53 degradation enhances p53's function as a tumor suppressor.	TP53 FBXW7	1.41e-05	2	131	2	31346036
Pubmed	ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.	ATRX H3-3A	1.41e-05	2	131	2	25538301
Pubmed	Ubiquitous p63 expression in human esophageal squamous cell carcinoma.	TP63 TP53	1.41e-05	2	131	2	15254760
Pubmed	ΔNp63/DGCR8-Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer.	TP63 TP53	1.41e-05	2	131	2	27300436
Pubmed	Prognostic significance of p53 and p63 immunolocalisation in primary and matched lymph node metastasis in oral squamous cell carcinoma.	TP63 TP53	1.41e-05	2	131	2	17499344
Pubmed	p63 deficiency activates a program of cellular senescence and leads to accelerated aging.	TP63 TP53	1.41e-05	2	131	2	16107615
Pubmed	p53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: a third member of the p53 family?	TP63 TP53	1.41e-05	2	131	2	9405685
Pubmed	Impaired repair of cyclobutane pyrimidine dimers in human keratinocytes deficient in p53 and p63.	TP63 TP53	1.41e-05	2	131	2	17984111
Pubmed	p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice.	TP63 TP53	1.41e-05	2	131	2	11522642
Pubmed	The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor in cancer cells.	RND3 TP53	1.41e-05	2	131	2	24399089
Pubmed	Radiologic findings and the molecular expression profile of diffuse midline glioma H3 K27M mutant.	ATRX TP53	1.41e-05	2	131	2	33175579
Pubmed	p63 (TP73L) a key player in embryonic urogenital development with significant dysregulation in human bladder exstrophy tissue.	TP63 TP53	1.41e-05	2	131	2	21042780
Pubmed	Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.	BRCA2 TP53	1.41e-05	2	131	2	31080552
Pubmed	A unique H3K4me2 profile marks tissue-specific gene regulation.	H3-4 H3-3A	1.41e-05	2	131	2	20841431
Pubmed	Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis.	BRCA2 TP53	1.41e-05	2	131	2	12414647
Pubmed	Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility.	TP53 FBXW7	1.41e-05	2	131	2	22348067
Pubmed	FBXW7 inactivation induces cellular senescence via accumulation of p53.	TP53 FBXW7	1.41e-05	2	131	2	36104351
Pubmed	DNA mismatch repair protein Msh6 is required for optimal levels of ultraviolet-B-induced apoptosis in primary mouse fibroblasts.	MSH6 TP53	1.41e-05	2	131	2	14632208
Pubmed	Loss of Fbxw7 triggers mammary tumorigenesis associated with E2F/c-Myc activation and Trp53 mutation.	TP53 FBXW7	1.41e-05	2	131	2	33070870
Pubmed	The expression of p63 and p53 in keratoacanthoma and intraepidermal and invasive neoplasms of the skin.	TP63 TP53	1.41e-05	2	131	2	19577853
Pubmed	Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer.	TP53 FBXW7	1.41e-05	2	131	2	22473991
Pubmed	Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways.	PPM1D TP53	1.41e-05	2	131	2	25879755
Pubmed	Wip1 regulates the generation of new neural cells in the adult olfactory bulb through p53-dependent cell cycle control.	PPM1D TP53	1.41e-05	2	131	2	19489034
Pubmed	Synergistic Effects of Arsenite on Radiosensitization of Glioblastoma Cells.	BRCA2 TP53	1.41e-05	2	131	2	28739695
Pubmed	Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation.	PPM1D TP53	1.41e-05	2	131	2	16585576
Pubmed	Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer.	TOPBP1 TP53	1.41e-05	2	131	2	19289498
Pubmed	ΔNp63-Senataxin circuit controls keratinocyte differentiation by promoting the transcriptional termination of epidermal genes.	SETX TP63	1.41e-05	2	131	2	35235452
Pubmed	Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C.	BRCA2 TP53	1.41e-05	2	131	2	32980867
Pubmed	Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma.	PPM1D TP53	1.41e-05	2	131	2	26847329
Pubmed	Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours.	BRCA2 TP53	1.41e-05	2	131	2	25692405
Pubmed	Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with DeltaNp73.	TP63 TP53	1.41e-05	2	131	2	18048390
Pubmed	p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.	TP63 TP53	1.41e-05	2	131	2	16714381
Interaction	H1-4 interactions	H3-5 LARP1 PHF8 NEB H3-4 H3-7 H3C15 TNRC18 RPS26P11 H3C1 NAT10 STAU2 TCEANC2 H3-3A ASXL2 BSN SPTY2D1 MOV10 FBXW7	2.60e-08	656	126	19	int:H1-4
Interaction	H2AX interactions	H3-5 ATRX COPG1 PPM1D NEB H3-4 H3-7 H3C15 MSH6 TNRC18 H3C1 BRCA2 SUPT16H H3-3A TIMELESS TP53 SYNCRIP FBXW7	3.09e-08	593	126	18	int:H2AX
Interaction	H1-3 interactions	H3-5 ATRX H3-4 H3-7 H3C15 NGDN TNRC18 RPS26P11 H3C1 TP63 H3-3A ASXL2 TP53	3.61e-08	291	126	13	int:H1-3
Interaction	DAXX interactions	H3-5 ATRX ZNF280C GPATCH4 H3-4 TNRC18 H3C1 BRCA2 TP63 SUPT16H H3-3A AFF4 TP53 SPIN3	4.64e-08	353	126	14	int:DAXX
Interaction	H3C1 interactions	H3-5 ATRX PPM1D ZNF280C LARP1 GPATCH4 PHF8 NEB H3-4 H3-7 H3C15 MSH6 TNRC18 H3C1 CCNB3 NAT10 SUPT16H H3-3A DTX2 AFF4 MOV10	1.80e-07	901	126	21	int:H3C1
Interaction	MCM5 interactions	H3-5 LARP1 H3-4 H3-7 H3C15 H3C1 ARHGEF1 NAT10 ARHGAP29 H3-3A AKAP11 TIMELESS TP53 SYNCRIP	3.88e-07	420	126	14	int:MCM5
Interaction	H4C9 interactions	ATRX H3-4 HELQ H3-7 H3C1 SUPT16H H3-3A SPTY2D1	3.89e-07	108	126	8	int:H4C9
Interaction	H1-1 interactions	H3-5 ZNF274 LARP1 GPATCH4 H3-4 H3-7 H3C15 NGDN RPS26P11 H3C1 NAT10 STAU2 H3-3A BSN MOV10	6.61e-07	507	126	15	int:H1-1
Interaction	TOPBP1 interactions	ATRX TOPBP1 PHF8 MSH6 BRCA2 TP63 H3-3A TP53	7.20e-07	117	126	8	int:TOPBP1
Interaction	H1-2 interactions	H3-5 ATRX TOPBP1 NEB H3-4 H3-7 H3C15 RGS7 H3C1 NAT10 H3-3A AKAP11 BOD1L1 ASXL2 BSN TP53 MOV10	8.81e-07	666	126	17	int:H1-2
Interaction	SETDB1 interactions	ZNF274 ATRX H3-4 H3C15 TOB1 H3C1 TIAM1 TP63 TP53 MOV10	9.75e-07	214	126	10	int:SETDB1
Interaction	SMC5 interactions	SETX H3-5 ATRX ZNF280C TOPBP1 LARP1 GPATCH4 H3-4 CWC22 H3C15 H3C1 BRCA2 NAT10 STAU2 SUPT16H H3-3A BOD1L1 TIMELESS AFF4 TP53 SYNCRIP	9.89e-07	1000	126	21	int:SMC5
Interaction	H2BC21 interactions	H3-5 ATRX PPM1D ZNF280C PHF8 NEB H3-4 H3-7 H3C15 MSH6 INTS6 H3C1 SUPT16H H3-3A AKAP11 TP53 FBXW7	1.61e-06	696	126	17	int:H2BC21
Interaction	DGCR8 interactions	LARP1 GPATCH4 NGDN MSH6 NAT10 STAU2 SPTY2D1 TP53 MOV10 ZNF646	2.95e-06	242	126	10	int:DGCR8
Interaction	NAT10 interactions	GPATCH4 H3-4 H3C15 NGDN IBTK H3C1 NAT10 H3-3A TP53 SYNCRIP FBXW7	3.14e-06	302	126	11	int:NAT10
Interaction	H2AC14 interactions	H3-5 H3-4 H3-7 H3C15 MSH6 H3C1 H3-3A TP53	3.45e-06	144	126	8	int:H2AC14
Interaction	TONSL interactions	ATRX H3-4 H3C15 H3C1 SUPT16H TP53 FBXW7	4.06e-06	104	126	7	int:TONSL
Interaction	H2AC18 interactions	H3-5 NEB H3-4 H3C15 TNRC18 H3C1 SUPT16H H3-3A	4.23e-06	148	126	8	int:H2AC18
Interaction	H3-3A interactions	H3-5 ATRX PPM1D ZNF280C TOPBP1 PHF8 H3-4 H3C15 MSH6 H3C1 TIAM1 NAT10 SUPT16H H3-3A BOD1L1 TIMELESS AFF4	4.30e-06	749	126	17	int:H3-3A
Interaction	KMT2A interactions	H3-4 H3C15 MED15 DLC1 H3C1 BRCA2 H3-3A BOD1L1 AFF4 TP53 FBXW7	4.57e-06	314	126	11	int:KMT2A
Interaction	SSRP1 interactions	SETX ATRX H3C15 RND3 MSH6 INTS6 H3C1 BRCA2 SUPT16H H3-3A TIMELESS DTX2 SPTY2D1 TP53 SYNCRIP FBXW7	5.89e-06	685	126	16	int:SSRP1
Interaction	WRN interactions	ATRX SUPT16H H3-3A TIMELESS DTX2 TP53 MOV10	5.89e-06	110	126	7	int:WRN
Interaction	NASP interactions	H3-5 H3-4 H3-7 H3C15 H3C1 TIAM1 BRCA2 H3-3A TIMELESS	6.24e-06	207	126	9	int:NASP
Interaction	SFN interactions	EXPH5 LARP1 NEB REEP3 DENND2B RRAGC RND3 TIAM1 TP63 SUPT16H AKAP11 DTX2 PLCH1 TP53 USP47 FBXW7	6.70e-06	692	126	16	int:SFN
Interaction	CDC14B interactions	ZNF280C PHF8 MSH6 DLC1 BRCA2 NAT10 TP53 USP47	6.86e-06	158	126	8	int:CDC14B
Interaction	H2BC13 interactions	H3-5 ATRX H3-4 H3-7 H3C15 TNRC18 H3C1 H3-3A TP53	7.01e-06	210	126	9	int:H2BC13
Interaction	H3-5 interactions	H3-5 PHF8 H3-4 H3C15 H3C1 SUPT16H H3-3A	7.47e-06	114	126	7	int:H3-5
Interaction	SETD1B interactions	H3C1 TP63 H3-3A BOD1L1 TP53 SYNCRIP	7.50e-06	75	126	6	int:SETD1B
Interaction	FBXL13 interactions	IL16 CYP26A1 NEB TOB1 BRCA2	7.88e-06	44	126	5	int:FBXL13
Interaction	H2AC12 interactions	H3-5 H3-4 H3-7 H3C15 H3C1 H3-3A FBXW7	9.37e-06	118	126	7	int:H2AC12
Interaction	MKRN1 interactions	LARP1 NAT10 STAU2 SUPT16H TP53 PURG MOV10 SYNCRIP	9.43e-06	165	126	8	int:MKRN1
Interaction	HMGA1 interactions	H3-5 ZNF280C H3-4 H3-7 H3C15 MED15 TNRC18 H3C1 BRCA2 H3-3A TP53 SYNCRIP	1.28e-05	419	126	12	int:HMGA1
Interaction	RSF1 interactions	H3C15 H3C1 BRCA2 SUPT16H ARHGAP29 H3-3A TP53	1.30e-05	124	126	7	int:RSF1
Interaction	H3C3 interactions	SETX ATRX ZNF280C TOPBP1 GPATCH4 PHF8 H3-7 MSH6 NAT10 SUPT16H BOD1L1 TIMELESS AFF4	1.38e-05	495	126	13	int:H3C3
Interaction	SENP6 interactions	ATRX H3C1 TIAM1 H3-3A TP53	1.49e-05	50	126	5	int:SENP6
Interaction	RPLP0 interactions	LARP1 GPATCH4 WASHC2A NGDN IBTK DNAJC15 TP63 NAT10 STAU2 PLCH1 SPTY2D1 TP53 PURG SYNCRIP FBXW7	1.63e-05	660	126	15	int:RPLP0
Interaction	BLM interactions	ATRX TOPBP1 PHF8 ZUP1 MSH6 H3C1 H3-3A TP53 FBXW7	1.97e-05	239	126	9	int:BLM
Interaction	AURKB interactions	SETX H3-5 LARP1 H3-4 H3C15 MSH6 RPS26P11 H3C1 BRCA2 NAT10 H3-3A TIMELESS TP53 MOV10 SYNCRIP FBXW7	2.17e-05	761	126	16	int:AURKB
Interaction	SUPT16H interactions	H3-5 ATRX NEB H3C15 MSH6 H3C1 SUPT16H H3-3A DTX2 TP53 MOV10 FBXW7	2.18e-05	442	126	12	int:SUPT16H
Interaction	H2BC9 interactions	H3-5 ATRX NEB H3-4 H3-7 H3C15 TNRC18 H3C1 SUPT16H H3-3A AKAP11 AFF4	2.38e-05	446	126	12	int:H2BC9
Interaction	DDX10 interactions	H3-4 WASHC2A NGDN H3C1 H3-3A BOD1L1 TP53 FBXW7	2.62e-05	190	126	8	int:DDX10
Interaction	RPS27A interactions	H3-5 ZNF274 PTPN23 NEB H3-4 H3C15 TNRC18 H3C1 FBXO43 H3-3A TP53 PURG SYNCRIP	3.17e-05	536	126	13	int:RPS27A
Interaction	FGFBP1 interactions	LARP1 GPATCH4 CWC22 NGDN VANGL1 NAT10 STAU2 SUPT16H SPTY2D1	3.49e-05	257	126	9	int:FGFBP1
Interaction	H2BC12 interactions	H3-5 ATRX LARP1 NEB H3-4 H3C15 TNRC18 H3C1 H3-3A ASXL2	3.54e-05	322	126	10	int:H2BC12
Interaction	POLK interactions	H3-4 MSH6 BRCA2 H3-3A TP53	3.66e-05	60	126	5	int:POLK
Interaction	NUP43 interactions	SETX ZNF280C TOPBP1 LARP1 GPATCH4 PHF8 CWC22 ZFX BRCA2 SUPT16H BOD1L1 TIMELESS ASXL2 TP53	3.71e-05	625	126	14	int:NUP43
Interaction	UHRF2 interactions	ZNF410 ATRX H3C1 NAT10 SUPT16H H3-3A TP53 FBXW7	3.78e-05	200	126	8	int:UHRF2
Interaction	TOP2B interactions	H3-5 TOPBP1 GPATCH4 MED15 H3C1 SUPT16H H3-3A TP53 FBXW7	4.56e-05	266	126	9	int:TOP2B
Interaction	UHRF1 interactions	H3-4 H3C15 MSH6 H3C1 SUPT16H H3-3A TP53 FBXW7	4.99e-05	208	126	8	int:UHRF1
Interaction	PRKCA interactions	NRGN H3-4 RGS7 IBTK H3C1 TIAM1 ARHGEF1 AKAP11 TP53 MOV10 FBXW7	5.18e-05	408	126	11	int:PRKCA
Interaction	RAG1 interactions	H3-4 H3C1 TP53 FBXW7	5.18e-05	33	126	4	int:RAG1
Interaction	H2AC7 interactions	H3-5 H3-4 H3C15 H3C1 H3-3A FBXW7	5.72e-05	107	126	6	int:H2AC7
Interaction	RAD9A interactions	ATRX TOPBP1 MSH6 BRCA2 FBXW7	5.81e-05	66	126	5	int:RAD9A
Interaction	MED9 interactions	NRGN PLEKHA6 MED15 MED12L USP47 FBXW7	6.02e-05	108	126	6	int:MED9
Interaction	IPO4 interactions	ARRDC4 H3-4 H3C1 H3-3A TP53 MOV10 SYNCRIP FBXW7	6.09e-05	214	126	8	int:IPO4
Interaction	PAF1 interactions	ATRX MED15 H3C1 TP63 SUPT16H AFF4 TP53 FBXW7	6.09e-05	214	126	8	int:PAF1
Interaction	NOP2 interactions	GPATCH4 H3-4 H3-7 RPS26P11 H3C1 NAT10 SPTY2D1 TP53 PURG MOV10 SYNCRIP	6.16e-05	416	126	11	int:NOP2
Interaction	CCNL1 interactions	GPATCH2 TP63 H3-3A TP53 FBXW7	6.25e-05	67	126	5	int:CCNL1
Interaction	MLST8 interactions	SETX LARP1 ZUP1 THADA MOV10 FBXW7	6.34e-05	109	126	6	int:MLST8
Interaction	NSD2 interactions	ATRX ZNF280C GPATCH4 H3-4 H3C1 TIAM1 BRCA2 H3-3A TP53	6.41e-05	278	126	9	int:NSD2
Interaction	H4C6 interactions	ATRX H3-7 SUPT16H H3-3A SPTY2D1	7.20e-05	69	126	5	int:H4C6
Interaction	MMS22L interactions	H3-4 H3C1 BRCA2 SUPT16H FBXW7	7.20e-05	69	126	5	int:MMS22L
Interaction	KDM6A interactions	H3-4 MSH6 H3C1 BOD1L1 ASXL2 TP53 FBXW7	7.22e-05	162	126	7	int:KDM6A
Interaction	CBX6 interactions	LARP1 H3-4 H3-7 H3C1 NAT10 STAU2 H3-3A SPTY2D1 MOV10	7.35e-05	283	126	9	int:CBX6
Interaction	CHD4 interactions	H3-5 LARP1 H3-4 CWC22 H3C15 ZUP1 MED15 MSH6 H3C1 BRCA2 NAT10 SUPT16H H3-3A RORC TP53 SYNCRIP FBXW7	7.61e-05	938	126	17	int:CHD4
Interaction	OASL interactions	LARP1 NGDN STAU2 SPTY2D1 PURG MOV10 SYNCRIP ZNF646	8.13e-05	223	126	8	int:OASL
Interaction	H3-3B interactions	ATRX H3-7 TIAM1 SUPT16H TIMELESS SPTY2D1	8.14e-05	114	126	6	int:H3-3B
Interaction	MECOM interactions	COPG1 NEB MSH6 H3C1 NAT10 SUPT16H DTX2 TP53 SYNCRIP FBXW7	8.58e-05	358	126	10	int:MECOM
Interaction	FAM50A interactions	CWC22 H3C1 TP63 H3-3A TP53 MOV10	8.97e-05	116	126	6	int:FAM50A
Interaction	NSD3 interactions	H3-5 PPM1D H3-4 H3C1 H3-3A BOD1L1	9.41e-05	117	126	6	int:NSD3
Interaction	H1-6 interactions	H3-5 H3-4 H3C15 NGDN H3C1 NAT10 H3-3A MOV10	9.78e-05	229	126	8	int:H1-6
Interaction	H2AC17 interactions	LARP1 GPATCH4 H3-7 NGDN NAT10 STAU2 SUPT16H MOV10	1.07e-04	232	126	8	int:H2AC17
Interaction	H2AC13 interactions	H3-5 H3-4 H3C15 H3C1 H3-3A	1.07e-04	75	126	5	int:H2AC13
Interaction	MED16 interactions	MED15 H3C1 NKD2 MED12L TP53 FBXW7	1.08e-04	120	126	6	int:MED16
Interaction	RAD50 interactions	ATRX LARP1 H3-4 ZUP1 MSH6 H3C1 BRCA2 H3-3A TP53 FBXW7	1.15e-04	371	126	10	int:RAD50
Interaction	AURKA interactions	ATRX COPG1 ITGB1BP1 LARP1 PTPN23 H3-4 NGDN DNAAF8 H3C1 H3-3A TIMELESS TP53 USP47 FBXW7	1.17e-04	696	126	14	int:AURKA
Interaction	ZBTB2 interactions	ZNF280C GPATCH4 NGDN MSH6 NAT10 STAU2 SUPT16H DTX2 TP53 MOV10 SYNCRIP	1.24e-04	450	126	11	int:ZBTB2
Interaction	DUSP16 interactions	EXPH5 PTPN23 WASHC2A BRCA2 ARHGEF1 AKAP11 PLCH1 FBXW7	1.24e-04	237	126	8	int:DUSP16
Interaction	H2AC8 interactions	H3-7 H3C1 SUPT16H TIMELESS SPTY2D1 TP53 MOV10	1.26e-04	177	126	7	int:H2AC8
Interaction	SUV39H1 interactions	IL16 H3-5 TOPBP1 H3-4 H3-7 H3C15 H3C1 H3-3A	1.28e-04	238	126	8	int:SUV39H1
Interaction	SETD7 interactions	ATRX H3-4 H3C1 H3-3A TP53	1.29e-04	78	126	5	int:SETD7
Interaction	KIF22 interactions	H3-4 H3C1 H3-3A TP53 MOV10 USP47	1.35e-04	125	126	6	int:KIF22
Interaction	HPF1 interactions	H3-4 H3C1 H3-3A USP47	1.36e-04	42	126	4	int:HPF1
Interaction	PMS2 interactions	COPG1 TOPBP1 MSH6 BRCA2 TP53	1.46e-04	80	126	5	int:PMS2
Interaction	H2AJ interactions	H3-5 H3-4 H3C15 H3C1 SUPT16H H3-3A	1.48e-04	127	126	6	int:H2AJ
Interaction	DCLRE1C interactions	BRCA2 AKAP11 TP53 FBXW7	1.49e-04	43	126	4	int:DCLRE1C
Interaction	PRDM2 interactions	H3-4 H3C1 H3-3A TP53	1.49e-04	43	126	4	int:PRDM2
Interaction	GRK5 interactions	LARP1 CWC22 NAT10 AFF4 MOV10 USP47 SPIN3	1.49e-04	182	126	7	int:GRK5
Interaction	NBN interactions	ATRX TOPBP1 H3-4 MSH6 H3C1 BRCA2 TP53	1.54e-04	183	126	7	int:NBN
Interaction	CHEK1 interactions	PPM1D TOPBP1 MED15 MSH6 BRCA2 TIMELESS TP53 FBXW7	1.56e-04	245	126	8	int:CHEK1
Interaction	H2AC11 interactions	NEB H3-4 H3C15 TNRC18 H3C1 CCNB3 NAT10 H3-3A	1.69e-04	248	126	8	int:H2AC11
Interaction	MNDA interactions	LARP1 GPATCH4 NGDN NAT10 STAU2 TP53 MOV10	1.82e-04	188	126	7	int:MNDA
Interaction	H2AC25 interactions	H3-5 H3-4 H3C15 H3C1 H3-3A	1.83e-04	84	126	5	int:H2AC25
Interaction	H2AC20 interactions	H3-5 H3-4 H3-7 H3C15 H3C1 NAT10 SUPT16H H3-3A ASXL2	1.86e-04	320	126	9	int:H2AC20
Interaction	CBX7 interactions	H3-4 H3C1 H3-3A MOV10	1.94e-04	46	126	4	int:CBX7
Interaction	LOC102724334 interactions	H3-5 H3-4 H3-7 H3C15 H3C1 H3-3A	1.98e-04	134	126	6	int:LOC102724334
Interaction	DNMT1 interactions	H3-4 MSH6 H3C1 BRCA2 DNAJC15 H3-3A TP53 FBXW7	1.99e-04	254	126	8	int:DNMT1
Interaction	PPM1G interactions	COPG1 H3-4 WASHC2A H3C1 DNAJC15 SUPT16H TCEANC2 H3-3A TP53	2.08e-04	325	126	9	int:PPM1G
Interaction	FEN1 interactions	MSH6 H3C1 BRCA2 H3-3A MOV10 USP47 FBXW7	2.14e-04	193	126	7	int:FEN1
Interaction	SMC6 interactions	ATRX H3C1 ZBED6 H3-3A TIMELESS	2.16e-04	87	126	5	int:SMC6
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3H TBC1D3L TBC1D3D TBC1D3B TBC1D3I TBC1D3G	4.73e-06	149	131	6	chr17q12
Cytoband	7p22.1	RSPH10B2 TNRC18 RSPH10B	3.36e-04	47	131	3	7p22.1
GeneFamily	Histones	H3-5 H3-4 H3-7 H3C15 H3C1 H3-3A	1.90e-05	116	86	6	864
GeneFamily	Regulating synaptic membrane exocytosis family\|PDZ domain containing	RIMS3 RIMS1	1.33e-04	4	86	2	833
GeneFamily	WASH complex	WASHC2C WASHC2A	3.31e-04	6	86	2	1331
GeneFamily	UPF1 like RNA helicases	SETX MOV10	1.20e-03	11	86	2	1169
GeneFamily	X-linked mental retardation\|RNA helicases	ATRX HELQ	1.20e-03	11	86	2	1168
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF410 ZNF274 ZNF177 ZNF652 ZNF596 ZUP1 ZFX ZNF710 ZNF792 ZNF646	2.13e-03	718	86	10	28
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCH1 PLCE1	3.63e-03	19	86	2	832
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	GPATCH2 GPATCH4	4.86e-03	22	86	2	579
GeneFamily	PDZ domain containing	IL16 SYNPO2L TIAM1 RIMS1	5.98e-03	152	86	4	1220
GeneFamily	Ataxins\|Trinucleotide repeat containing	MED15 TNRC18	6.25e-03	25	86	2	775
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATRX IBTK TNRC18 DNAJC15 NAT10 HYDIN MOV10	5.98e-07	165	131	7	436ce4bc75e1ba4351c439ccad19f84ad5bcb92f
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ATRX IBTK TNRC18 DNAJC15 NAT10 HYDIN MOV10	5.98e-07	165	131	7	242bdb7654f415391fb8e9bdc06412c7eee9c97e
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	EXPH5 ZNF652 ZBED6 VPS35L RSPH10B SYNCRIP	6.17e-06	153	131	6	553dff9688a1996d8f4ba16e60c683593d781389
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P3-Tnr-Polydendrocyte.Tnr.Cyth3_(Cyth3)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	EXPH5 ZNF652 ZBED6 VPS35L RSPH10B SYNCRIP	6.17e-06	153	131	6	88ca2d2c2ab19fbee13e18951b993ee05dd30f67
ToppCell	10x5'-Lung-Lymphocytic_T_CD4/8-lo-Trm_Tgd\|Lung / Manually curated celltypes from each tissue	H3-5 ZNF596 ITGAE VANGL1 STAU2 TCEANC2	1.02e-05	167	131	6	dcbcc658082910838c8082d71a64917055086cc4
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARRDC4 EXPH5 NPAS3 SEMA3G ATP10A PLCE1	1.56e-05	180	131	6	d685fa2b013bc085dbef7c40956ed3043f83e483
ToppCell	COVID-19-kidney-Podocyte\|kidney / Disease (COVID-19 only), tissue and cell type	ARRDC4 EXPH5 NPAS3 SEMA3G ATP10A PLCE1	1.71e-05	183	131	6	fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP26A1 NPAS3 RND3 QRFPR TIAM1 PLCH1	2.05e-05	189	131	6	06c44746fa4f02e6e2b3b635cdf2d8dfef3754d3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP26A1 NPAS3 DENND2B QRFPR TIAM1 PLCH1	2.31e-05	193	131	6	2189da4b727e25e62669d7b9257f06493be21a27
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CYP26A1 NPAS3 DENND2B QRFPR TIAM1 PLCH1	2.31e-05	193	131	6	3ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
Disease	Malignant Glioma	ATRX PPM1D BRCA2 H3-3A TP53 FBXW7	3.83e-07	70	118	6	C0555198
Disease	mixed gliomas	ATRX PPM1D BRCA2 H3-3A TP53 FBXW7	3.83e-07	70	118	6	C0259783
Disease	GLIOMA SUSCEPTIBILITY 1	H3C1 H3-3A TP53	1.24e-06	6	118	3	C2750850
Disease	Glioma	ATRX PPM1D BRCA2 H3-3A TP53 FBXW7	1.40e-06	87	118	6	C0017638
Disease	mismatch repair cancer syndrome (is_implicated_in)	SLC22A9 MSH6 TP53	1.34e-05	12	118	3	DOID:0112182 (is_implicated_in)
Disease	Malignant neoplasm of breast	PPM1D GSDMB HELQ FSCB OR1N1 SLC22A9 MSH6 BRCA2 ARHGAP29 BOD1L1 TIMELESS TP53 PURG FBXW7 ZNF646	2.58e-05	1074	118	15	C0006142
Disease	Malignant Squamous Cell Neoplasm	BRCA2 TP63	4.74e-05	3	118	2	C0751688
Disease	Squamous Cell Neoplasms	BRCA2 TP63	4.74e-05	3	118	2	C0206720
Disease	BREAST CANCER	PPM1D BRCA2 TP53	7.87e-05	21	118	3	114480
Disease	osteosarcoma (implicated_via_orthology)	BRCA2 TP53	9.46e-05	4	118	2	DOID:3347 (implicated_via_orthology)
Disease	Carcinoma of lung	BRCA2 TP63 TP53	1.04e-04	23	118	3	C0684249
Disease	breast cancer (implicated_via_orthology)	MSH6 BRCA2 TP53	1.34e-04	25	118	3	DOID:1612 (implicated_via_orthology)
Disease	testicular cancer (implicated_via_orthology)	TP63 TP53	1.57e-04	5	118	2	DOID:2998 (implicated_via_orthology)
Disease	Malignant tumor of breast	PPM1D BRCA2 TP53	1.70e-04	27	118	3	cv:C0006142
Disease	Breast neoplasm	PPM1D BRCA2 TP53	1.70e-04	27	118	3	cv:C1458155
Disease	Familial cancer of breast	PPM1D BRCA2 TP53	1.70e-04	27	118	3	cv:C0346153
Disease	ovarian neoplasm	MSH6 DLC1 BRCA2 TP63 TP53	2.08e-04	134	118	5	C0919267
Disease	Neoplasm of uncertain or unknown behavior of ovary	MSH6 BRCA2 TP53	2.11e-04	29	118	3	C0496920
Disease	Malignant neoplasm of ovary	MSH6 DLC1 BRCA2 TP63 TP53	2.30e-04	137	118	5	C1140680
Disease	Ovarian Carcinoma	MSH6 BRCA2 TP53	2.34e-04	30	118	3	C0029925
Disease	Breast Cancer, Familial	PPM1D MSH6 BRCA2	2.34e-04	30	118	3	C0346153
Disease	Adult only	MSH6 BRCA2	2.35e-04	6	118	2	C3842001
Disease	Abnormal corpus callosum morphology	SUPT16H MED12L	2.35e-04	6	118	2	C1842581
Disease	Colorectal Carcinoma	ITPRID1 SLC22A9 MSH6 DLC1 TIAM1 CCNB3 ARHGEF1 TP63 TP53 FBXW7	5.30e-04	702	118	10	C0009402
Disease	squamous cell lung carcinoma	NPAS3 NEB BRCA2 TP63 RIMS1	5.41e-04	165	118	5	EFO_0000708
Disease	Pancreatic carcinoma, familial	BRCA2 TP53	5.60e-04	9	118	2	C2931038
Disease	Glioma	BRCA2 TP53	5.60e-04	9	118	2	cv:C0017638
Disease	Cleft palate with cleft lip	TP63 ARHGAP29	5.60e-04	9	118	2	C0158646
Disease	Adenocarcinoma of large intestine	MSH6 DLC1 TP53 FBXW7	6.08e-04	96	118	4	C1319315
Disease	high grade glioma (is_implicated_in)	ATRX BRCA2 TP53	6.39e-04	42	118	3	DOID:3070 (is_implicated_in)
Disease	Uterine leiomyoma, estrogen-receptor negative breast cancer	EXPH5 TP53	6.99e-04	10	118	2	EFO_1000650, HP_0000131
Disease	Pancreatic Neoplasm	ATRX BRCA2 TP63 TP53	7.09e-04	100	118	4	C0030297
Disease	Malignant neoplasm of pancreas	ATRX BRCA2 TP63 TP53	7.64e-04	102	118	4	C0346647
Disease	gastric adenocarcinoma (is_implicated_in)	TP53 PLCE1	8.52e-04	11	118	2	DOID:3717 (is_implicated_in)
Disease	Benign tumor of pancreas	BRCA2 TP53	1.20e-03	13	118	2	C0347284
Disease	Carcinoma, Granular Cell	CYP26A1 TP63 TP53 PLCE1	1.23e-03	116	118	4	C0205644
Disease	Adenocarcinoma, Tubular	CYP26A1 TP63 TP53 PLCE1	1.23e-03	116	118	4	C0205645
Disease	Adenocarcinoma, Oxyphilic	CYP26A1 TP63 TP53 PLCE1	1.23e-03	116	118	4	C0205642
Disease	Carcinoma, Cribriform	CYP26A1 TP63 TP53 PLCE1	1.23e-03	116	118	4	C0205643
Disease	Adenocarcinoma, Basal Cell	CYP26A1 TP63 TP53 PLCE1	1.23e-03	116	118	4	C0205641
Disease	Adenocarcinoma	CYP26A1 TP63 TP53 PLCE1	1.23e-03	116	118	4	C0001418
Disease	Hereditary Breast and Ovarian Cancer Syndrome	BRCA2 TP53	1.40e-03	14	118	2	C0677776
Disease	platelet crit	ATRX EXPH5 CYP26A1 PLEKHA6 DENND2B THADA ARHGAP29 KLHL8 MOV10 PLCE1 SPIN3	1.54e-03	952	118	11	EFO_0007985
Disease	Multiple congenital anomalies	TP63 AFF4	2.07e-03	17	118	2	C0000772
Disease	total blood protein measurement	CYP26A1 ZFX TP63 ARHGAP29 H3-3A HYDIN PLCE1	2.23e-03	449	118	7	EFO_0004536
Disease	non-high density lipoprotein cholesterol measurement	CYP26A1 THADA DLC1 BRCA2 H3-3A SPTY2D1 HYDIN TP53 PLCE1	2.31e-03	713	118	9	EFO_0005689
Disease	blood urea nitrogen measurement	PPM1D ZNF652 CYP26A1 GPATCH2 PLEKHA6 ASXL2 PLCE1	2.32e-03	452	118	7	EFO_0004741
Disease	Malignant neoplasm of endometrium	MSH6 FBXW7	2.33e-03	18	118	2	C0007103
Disease	Carcinoma in situ of endometrium	MSH6 FBXW7	2.33e-03	18	118	2	C0346191
Disease	MYELODYSPLASTIC SYNDROME	ATRX BRCA2 TP53	2.48e-03	67	118	3	C3463824
Disease	Pancreatic carcinoma	BRCA2 TP53	2.59e-03	19	118	2	C0235974
Disease	gestational age, birth measurement	NPAS3 RND3	3.17e-03	21	118	2	EFO_0005112, EFO_0006921
Disease	haptoglobin measurement	DLC1 HYDIN	3.17e-03	21	118	2	EFO_0004640
Disease	colorectal carcinoma (is_implicated_in)	MSH6 TP53	3.48e-03	22	118	2	DOID:0080199 (is_implicated_in)
Disease	axial length measurement	TP63 STAU2 TIMELESS	3.68e-03	77	118	3	EFO_0005318
Disease	malignant astrocytoma (is_marker_for)	IL16 ATRX	3.80e-03	23	118	2	DOID:3069 (is_marker_for)
Disease	allergic disease	ZNF177 ZNF652 NPAS3 GSDMB RORC	3.86e-03	258	118	5	MONDO_0005271
Disease	mean arterial pressure	WASHC2C ZNF652 CYP26A1 SYNPO2L THADA MOV10 PLCE1	4.00e-03	499	118	7	EFO_0006340

Protein segments in the cluster

Peptide	Gene	Start	Entry
TASKFRAAKHMAGLK	VANGL1	296	Q8TAA9
RQHREVSMGLTKSKN	C2orf16	441	Q68DN1
MRHLGVRTKSGDKKS	ARHGEF1	226	Q92888
LMKKHRIRAVATQGS	CNTNAP1	76	P78357
FVASKKIRMHQTSAK	DIXDC1	91	Q155Q3
NKETMNIHFRGKTKS	GSDMB	216	Q8TAX9
NNHMKTKASVRKSFS	AKAP11	6	Q9UKA4
KDMRGHRKSQSRKSF	DENND2B	436	P78524
KQMAHAVRGKAIRSS	ASXL2	1271	Q76L83
GSRAEAKRASMLSKH	ATP10A	506	O60312
MPSSRHKAATKGSRK	AFF4	596	Q9UHB7
LKRKHATQGTMSHLK	CCNB3	491	Q8WWL7
SGKTKTIRHMVANVR	ARRDC4	241	Q8NCT1
RHGNSGITMMRKKAK	QRFPR	361	Q96P65
SSLNKGKKLMHCRSH	INTS6	791	Q9UL03
DSSLRGKQRMSKHNF	PTPN23	1591	Q9H3S7
AKIQASFRGHMARKK	NRGN	31	Q92686
SHERVSKMNFKLTGK	RSPH10B	721	P0C881
SHERVSKMNFKLTGK	RSPH10B2	721	B2RC85
DAKMPRKRKTRHSSN	LARP1	811	Q6PKG0
SCKRSGKHRAMAVAK	MED12L	516	Q86YW9
KRKHGQEMTSKSLQT	FSCB	61	Q5H9T9
TSVSAAKEHRRRMGK	ITPRID1	241	Q6ZRS4
LASKSHGSVKRLRKM	DTX2	366	Q86UW9
HGSVKRLRKMSVKGA	DTX2	371	Q86UW9
TVSHGVKLSQKQRKM	IBTK	1146	Q9P2D0
MARTKQTARKSTGGK	H3-3A	1	P84243
AAISSKRSKHRKQGM	BSN	3351	Q9UPA5
KRSKHRKQGMEQKIS	BSN	3356	Q9UPA5
RSKSKEMNRKHSGSR	CWC22	851	Q9HCG8
HKTAAQARRRLMSGK	SYNCRIP	296	O60506
SHGSRRKASKVMVVL	ITGAE	296	P38570
MARTKQTARKSTGGK	H3-7	1	Q5TEC6
TAHKAARLGITMKAK	GPATCH4	156	Q5T3I0
MARTKQTARKSTGGK	H3-5	1	Q6NXT2
MSSKQARNHITKGKR	KLHL8	6	Q9P2G9
MESHSRAGKSRKSAK	IL16	1	Q14005
MHTKKRVSSFRGNKI	NPIPB8	141	E9PQR5
AMRKAGVAHSKSSKD	MED15	26	Q96RN5
ENRSSVKHRLAAMSK	EXPH5	1586	Q8NEV8
VKHRLAAMSKASRKF	EXPH5	1591	Q8NEV8
MARTKQTARKSTGGK	H3-4	1	Q16695
SKKGQSTSRHKKLMF	TP53	371	P04637
LMKKHRRNGLSRSSG	PPM1D	546	O15297
MARTKQTARKSTGGK	H3C1	1	P68431
KRMVTGNGSLKRKSS	MSH6	301	P52701
MGKLQSKHAAAARKR	NKD2	1	Q969F2
KELGFSSHRKKRMRQ	NAT10	61	Q9H0A0
SLAMAKERAHQKRSS	SLC9A3R1	326	O14745
HKMNSVEGRKKAFTT	OR2T10	226	Q8NGZ9
KMKVHRFKQTTGSGS	RIMS1	1296	Q86UR5
MKSKRKRLQENSGHE	FBXO43	451	Q4G163
NTHGIQMTSIKKRRS	TP63	381	Q9H3D4
MSKAALTHKFRKLRS	ARHGAP29	606	Q52LW3
SHEKARGNSSLMEKK	BOD1L1	1051	Q8NFC6
KSMSKIGAARTTKKR	ATRX	826	P46100
SGRKKVTAVHKANIM	IDH3G	211	P51553
KDKRHMALNRKVLSG	HYDIN	2696	Q4G0P3
NSRHKSLRTVKTKMD	BRCA2	111	P51587
SAGKAKIRTAHRRVM	DNAJC15	106	Q9Y5T4
TKMKRKLDHGSEVRS	FBXW7	166	Q969H0
SRTGRKQHMKLCAKG	DNAAF8	471	Q8IYS4
GSMFRSKRKKLHITS	FAM43A	51	Q8N2R8
SSHKQRKKVIMRAFS	CYP26A1	131	O43174
VNKMISKVTRHGLKS	COPG1	211	Q9Y678
RRKSIKDHLKNAMTG	HELQ	261	Q8TDG4
SRLHGMSSKNIKKSG	GPATCH2	346	Q9NW75
QGKRRKSLKSHSGRM	HHIPL2	696	Q6UWX4
MHTKKRVSSFRGNKI	NPIPB6	141	E9PJ23
MFRKGKKRHSSSSSQ	ITGB1BP1	1	O14713
LKMHSAKGRQKAFST	OR5T3	256	Q8NGG3
NSHKEKRMDGRKASG	PURG	326	Q9UJV8
KRNKSQRATKRISHM	RND3	206	P61587
RNKDMKGALKRLFSH	OR1N1	291	Q8NGS0
RRRHGESSKAVHKKM	FAM74A4	91	Q5TZK3
HSKGVLMFKKRRQRA	SYNPO2L	291	Q9H987
KSSRMRNPHKTRKSV	RGS7	216	P49802
RSGKSSIQKVVFHKM	RRAGC	71	Q9HB90
LKSTRIGHTVNKMRK	TCEANC2	76	Q96MN5
GVKRAKDEHSKTNRM	THADA	1266	Q6YHU6
RRMKLGSDISKHHKS	MOV10	91	Q9HCE1
TRKAKMHKECRSRSG	PLCE1	1106	Q9P212
TAKKRRSSLGAKMVA	RIMS3	41	Q9UJD0
LKELRKAAHRSGMKN	SLC22A9	296	Q8IVM8
KAAHRSGMKNARDTL	SLC22A9	301	Q8IVM8
ILSKLSQGQKTKHRM	PRORY	161	Q9H606
MARTKQTARKSTGGK	H3C15	1	Q71DI3
LHKRKGLKVRKSMST	SPPL2C	666	Q8IUH8
VHKFRRTSVMRNGKT	SETX	1841	Q7Z333
RMKSTLTKRGVHIKS	NPAS3	266	Q8IXF0
KERMSKHAQTFGAKQ	SKIV2L	526	Q15477
KHLRASMKKLTRKQG	TBC1D3L	341	B9A6J9
LKMHSTKGRHKAFST	OR5P3	226	Q8WZ94
KARAMAKRTKDNFHG	SPTY2D1	81	Q68D10
MSRKRKASVHSSGRG	SUPT16H	1016	Q9Y5B9
THKGLRRSQSMKSVK	REEP3	216	Q6NUK4
FSMKGHEKTAKSKTR	DLC1	651	Q96QB1
QMLHKSKGRTKTSPN	CHODL	241	Q9H9P2
RGHGRKAFVSTKMTS	CNK3/IPCEF1	451	G9CGD6
KHLRASMKKLTRKQG	TBC1D3B	341	A6NDS4
KHLRASMKKLTRKQG	TBC1D3H	341	P0C7X1
SREGKHKRAAKTRKM	TNRC18	1691	O15417
KMKVHSAGRRDVRAK	TAS2R5	201	Q9NYW4
LGHIMKNITAKRSRA	TIMELESS	911	Q9UNS1
KAVAFGKRSHSMKRN	PLEKHA6	41	Q9Y2H5
GKTFSKNSNLRRHEM	ZNF596	201	Q8TC21
RKVMKGNHSRKTAAF	VPS35L	686	Q7Z3J2
QSSLKKHMRSHTGEK	ZNF177	296	Q13360
VKFGRMSKKQRDSLH	RORC	101	P51449
KTLDSHASRMAQLKK	TIAM1	1541	Q13009
KGRRKRANVMSSQLH	NGDN	256	Q8NEJ9
GKTRQAARHNAAMKA	STAU2	161	Q9NUL3
MTKKRRNNSHAKKGR	RPS26P11	1	Q5JNZ5
GSVSVTMIKRKAAHK	SPIN3	21	Q5JUX0
KTFSQSGSRNVHMRK	ZNF410	346	Q86VK4
RKRDSQVKSMKHNSR	ZNF274	451	Q96GC6
MKKESSRLQKTGHRV	USP47	1336	Q96K76
SKGFSNLMSLKNHRR	ZNF646	1236	O15015
SSKFNLKGNLSRHMK	ZNF710	581	Q8N1W2
DTLHSANKSRVKMRG	WASHC2C	1001	Q9Y4E1
HRERKRASKSSKHSM	SOSTDC1	191	Q6X4U4
RSLMTNFGKHKKTTK	PLCH1	546	Q4KWH8
KMKNSGRSNKVARTS	TOB1	191	P50616
ADTLHSANKSRVKMR	WASHC2A	1021	Q641Q2
NRMGKKHDKSASDAL	ZBED6	226	P86452
SSLKQLRKSMGNLKH	ZUP1	531	Q96AP4
QSELKKHMKTHSGRK	ZFX	731	P17010
GKAFSRSSDLMKHQR	ZNF792	456	Q3KQV3
SIMKKRRGSSKGHDT	PHF8	96	Q9UPP1
GKKMKSRVHAEHNRT	SEMA3G	761	Q9NS98
KHLRASMKKLTRKQG	TBC1D3D	341	A0A087WVF3
GKAFKQSSKLNEHMR	ZNF355P	106	Q9NSJ1
SSGLDRMAKHLSQRK	ZNF280C	696	Q8ND82
TCGKSFKRSMSLKVH	ZNF652	361	Q9Y2D9
KHLRASMKKLTRKQG	TBC1D3G	341	Q6DHY5
RKSNAKKGMFASTHL	TOPBP1	681	Q92547
KHLRASMKKLTRKQG	TBC1D3I	341	A0A087WXS9
MKSKTSRHLIQKGQE	LRRIQ3	321	A6PVS8
KMLHSLKTAKNQSDR	NEB	866	P20929