Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2D SETD1B	3.35e-04	8	70	2	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2D SETD1B	5.35e-04	10	70	2	GO:0140999
GeneOntologyMolecularFunction	protein phosphatase inhibitor activity	BOD1 PHACTR4 CABIN1	7.19e-04	50	70	3	GO:0004864
GeneOntologyMolecularFunction	protein phosphatase binding	CDKN1B BOD1 PHACTR4 CABIN1 PTK2	8.53e-04	210	70	5	GO:0019903
GeneOntologyMolecularFunction	phosphatase inhibitor activity	BOD1 PHACTR4 CABIN1	9.00e-04	54	70	3	GO:0019212
GeneOntologyMolecularFunction	profilin binding	PCLO HTT	9.22e-04	13	70	2	GO:0005522
GeneOntologyCellularComponent	Set1C/COMPASS complex	BOD1 SETD1B HCFC1	2.04e-05	16	71	3	GO:0048188
GeneOntologyCellularComponent	tight junction	OCEL1 TJP1 SIPA1L3 CCDC85C CLDN23	1.11e-04	139	71	5	GO:0070160
GeneOntologyCellularComponent	histone methyltransferase complex	BOD1 KMT2D SETD1B HCFC1	1.24e-04	75	71	4	GO:0035097
GeneOntologyCellularComponent	super elongation complex	AFF2 AFF1	1.69e-04	6	71	2	GO:0032783
GeneOntologyCellularComponent	contractile actin filament bundle	GAS2L2 SIPA1L3 BAG3 PTK2	4.84e-04	107	71	4	GO:0097517
GeneOntologyCellularComponent	stress fiber	GAS2L2 SIPA1L3 BAG3 PTK2	4.84e-04	107	71	4	GO:0001725
GeneOntologyCellularComponent	methyltransferase complex	BOD1 KMT2D SETD1B HCFC1	5.02e-04	108	71	4	GO:0034708
GeneOntologyCellularComponent	actomyosin	GAS2L2 SIPA1L3 BAG3 PTK2	6.78e-04	117	71	4	GO:0042641
GeneOntologyCellularComponent	actin filament bundle	GAS2L2 SIPA1L3 BAG3 PTK2	7.00e-04	118	71	4	GO:0032432
GeneOntologyCellularComponent	cell-cell junction	OCEL1 TJP1 SIPA1L3 CCDC85C PANX2 CLDN23 PTK2 ADD1	8.65e-04	591	71	8	GO:0005911
GeneOntologyCellularComponent	nuclear body	TCF7L2 SETD1B AFF2 ATF7IP GRK5 YLPM1 CBX4 PTK2 ADD1 FOXC2	9.10e-04	903	71	10	GO:0016604
GeneOntologyCellularComponent	bicellular tight junction	OCEL1 TJP1 CCDC85C CLDN23	1.03e-03	131	71	4	GO:0005923
GeneOntologyCellularComponent	cytoplasmic region	RPGRIP1 LCA5 SPAST PCLO PRKAR2A HTT	1.40e-03	360	71	6	GO:0099568
GeneOntologyCellularComponent	anchoring junction	OCEL1 TJP1 SIPA1L3 CCDC85C PRKAR2A SRCIN1 PANX2 CLDN23 PTK2 ADD1	1.63e-03	976	71	10	GO:0070161
GeneOntologyCellularComponent	apical junction complex	OCEL1 TJP1 CCDC85C CLDN23	2.06e-03	158	71	4	GO:0043296
GeneOntologyCellularComponent	actin cytoskeleton	GAS2L2 TJP1 SIPA1L3 BAG3 SRCIN1 PTK2 ADD1	3.37e-03	576	71	7	GO:0015629
GeneOntologyCellularComponent	inclusion body	BAG3 CABIN1 HTT	3.57e-03	90	71	3	GO:0016234
Domain	TF_AF4/FMR2	AFF2 AFF1	7.80e-05	4	68	2	IPR007797
Domain	AF-4	AFF2 AFF1	7.80e-05	4	68	2	PF05110
Domain	PDZ	MAST4 TJP1 GORASP1 PCLO SIPA1L3	2.24e-04	151	68	5	PS50106
Domain	PDZ	MAST4 TJP1 GORASP1 PCLO SIPA1L3	2.31e-04	152	68	5	IPR001478
Domain	MIT	SPAST CAPN7	5.77e-04	10	68	2	SM00745
Domain	MIT	SPAST CAPN7	5.77e-04	10	68	2	PF04212
Domain	Hairy_orange	HES7 HES5	8.42e-04	12	68	2	PF07527
Domain	Orange_dom	HES7 HES5	8.42e-04	12	68	2	IPR003650
Domain	ORANGE	HES7 HES5	9.93e-04	13	68	2	PS51054
Domain	MIT	SPAST CAPN7	1.16e-03	14	68	2	IPR007330
Domain	Post-SET_dom	KMT2D SETD1B	1.52e-03	16	68	2	IPR003616
Domain	PostSET	KMT2D SETD1B	1.52e-03	16	68	2	SM00508
Domain	POST_SET	KMT2D SETD1B	1.52e-03	16	68	2	PS50868
Domain	-	MAST4 TJP1 GORASP1 SIPA1L3	2.18e-03	150	68	4	2.30.42.10
Pathway	REACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES	BOD1 KMT2D SETD1B HCFC1	1.54e-05	42	51	4	M48018
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	KMT2D GTF3C1 TJP1 PHACTR4 NFKBIE BAG3 YLPM1 CCDC85C RPRD2 HCFC1 ADD1 PRRC2B HTT	8.27e-11	549	71	13	38280479
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KMT2D SETD1B ZNF48 SEMA7A ADAMTS7 BICRA CASKIN1 GRK5 SIPA1L3 HELZ2 CABIN1 HCFC1 ADCY7 CLDN23 PRRC2B HTT	6.01e-10	1105	71	16	35748872
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	BOD1 KMT2D SETD1B HCFC1	1.13e-07	22	71	4	26886794
Pubmed	Human transcription factor protein interaction networks.	IRF2BP2 KMT2D TCF7L2 GTF3C1 BICRA ATF7IP SUPT7L NFKBIE YLPM1 CCDC85C RPRD2 CABIN1 GARRE1 HCFC1 PRRC2B	1.57e-07	1429	71	15	35140242
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	MYPOP KMT2D TCF7L2 ZNF48 GTF3C1 SUPT7L HES7 YLPM1 RPRD2 CBX4 CDC6 CABIN1 HCFC1 STT3B	3.01e-07	1294	71	14	30804502
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	BOD1 TJP1 SIPA1L3 NFKBIE BAG3 CCDC85C PRKAR2A HS1BP3 CDC6 PRRC2B NUP35 STT3B	8.65e-07	1007	71	12	34597346
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	IRF2BP2 KMT2D SUPT7L YLPM1 RPRD2 HCFC1 PRRC2B	1.30e-06	268	71	7	33640491
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2D SETD1B HCFC1	1.77e-06	12	71	3	27563068
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	CDKN1B SPAST GTF3C1 PRKAR2A HS1BP3 ADD1 HTT	2.10e-06	288	71	7	23383273
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	BORCS6 IRF2BP2 KMT2D TJP1 SIPA1L3 RPRD2	2.18e-06	184	71	6	32908313
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	TJP1 SIPA1L3 PHACTR4 NFKBIE BAG3 CCDC85C SRCIN1 HCFC1 ADD1	2.25e-06	565	71	9	25468996
Pubmed	Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.	BOD1 KMT2D SETD1B HCFC1	3.42e-06	50	71	4	37974198
Pubmed	Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.	CDKN1B HES7 HES5	3.64e-06	15	71	3	14672936
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CDKN1B IRF2BP2 KMT2D GTF3C1 PHACTR4 BAG3 YLPM1 HELZ2 AFF1 ADD1	3.82e-06	774	71	10	15302935
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	PRR36 TJP1 ATF7IP CASKIN1 SIPA1L3 YLPM1 PRKAR2A CABIN1 PTK2 ADD1 PRRC2B	3.89e-06	963	71	11	28671696
Pubmed	Bis induces growth inhibition and differentiation of HL-60 cells via up-regulation of p27.	CDKN1B BAG3	4.11e-06	2	71	2	16391524
Pubmed	Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.	MEF2B KMT2D	4.11e-06	2	71	2	21796119
Pubmed	GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression.	TJP1 BICRA	4.11e-06	2	71	2	35218185
Pubmed	Cloning and mapping of the alpha-adducin gene close to D4S95 and assessment of its relationship to Huntington disease.	ADD1 HTT	4.11e-06	2	71	2	1284592
Pubmed	Unraveling the Role of Huntingtin in Breast Cancer Metastasis.	TJP1 HTT	4.11e-06	2	71	2	26293574
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	LCA5 MAST4 TJP1 CAPN7 SIPA1L3 PHACTR4 NFKBIE CCDC85C GARRE1 PRRC2B	8.93e-06	853	71	10	28718761
Pubmed	Lack of genetic susceptibility in takotsubo cardiomyopathy: a case-control study.	GRK5 BAG3	1.23e-05	3	71	2	29514624
Pubmed	p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain.	CDKN1B PTK2	1.23e-05	3	71	2	15557280
Pubmed	HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.	BAG3 HTT	1.23e-05	3	71	2	18006506
Pubmed	PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment.	BAG3 PTK2	1.23e-05	3	71	2	28103122
Pubmed	[AF4/FMR2 and IL-10 gene single nucleotide polymorphisms are correlated with disease susceptibility and immune infiltration in ankylosing spondylitis].	AFF2 AFF1	1.23e-05	3	71	2	37313815
Pubmed	Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations.	ATF7IP HTT	1.23e-05	3	71	2	30452683
Pubmed	FAK is required for Schwann cell spreading on immature basal lamina to coordinate the radial sorting of peripheral axons with myelination.	CDKN1B PTK2	1.23e-05	3	71	2	25274820
Pubmed	BAG3 regulates formation of the SNARE complex and insulin secretion.	BAG3 PTK2	1.23e-05	3	71	2	25766323
Pubmed	Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2.	MEF2B CABIN1	1.23e-05	3	71	2	12700764
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	IRF2BP2 BICRA BAG3 YLPM1 PRKAR2A RPRD2 HCFC1	1.76e-05	399	71	7	35987950
Pubmed	Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity.	CDKN1B TJP1 HES5	1.82e-05	25	71	3	19389377
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	IRF2BP2 TJP1 ATF7IP BAG3 YLPM1 CCDC85C RPRD2 HCFC1 ADD1 PRRC2B	1.95e-05	934	71	10	33916271
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CDKN1B GTF3C1 TJP1 GORASP1 SIPA1L3 YLPM1 CCDC85C PRKAR2A CDC6 HCFC1 PRRC2B	2.13e-05	1155	71	11	20360068
Pubmed	MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma.	MEF2B CABIN1	2.46e-05	4	71	2	23974956
Pubmed	Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms.	CDKN1B PTK2	2.46e-05	4	71	2	16705171
Pubmed	Cdc6 determines utilization of p21(WAF1/CIP1)-dependent damage checkpoint in S phase cells.	CDKN1B CDC6	2.46e-05	4	71	2	18458079
Pubmed	Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization.	TJP1 SIPA1L3	2.46e-05	4	71	2	26231217
Pubmed	Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice.	AFF2 AFF1	2.46e-05	4	71	2	11923441
Pubmed	Mediation of Af4 protein function in the cerebellum by Siah proteins.	AFF2 AFF1	2.46e-05	4	71	2	15459319
Pubmed	Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.	MEF2B CABIN1	2.46e-05	4	71	2	10531067
Pubmed	Functional proteomics mapping of a human signaling pathway.	KMT2D MAST4 CPXM2 ATF7IP GORASP1 YLPM1 AFF1 CBX4	2.76e-05	591	71	8	15231748
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TCF7L2 AFF2 BICRA YLPM1 AFF1 PTK2 SOS2	2.83e-05	430	71	7	35044719
Pubmed	Identification and characterization of a novel human PP1 phosphatase complex.	KMT2D SETD1B HCFC1	3.52e-05	31	71	3	20516061
Pubmed	c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.	GRK5 PTK2	4.09e-05	5	71	2	27232975
Pubmed	The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo.	PCLO PTK2	4.09e-05	5	71	2	12473661
Pubmed	Calpain induces N-terminal truncation of β-catenin in normal murine liver development: diagnostic implications in hepatoblastomas.	TCF7L2 PTK2	4.09e-05	5	71	2	22613727
Pubmed	p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.	SRCIN1 PTK2	4.09e-05	5	71	2	17525734
Pubmed	Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population.	TCF7L2 FOXC2	4.09e-05	5	71	2	20540670
Pubmed	Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy.	RPGRIP1 LCA5	4.09e-05	5	71	2	25018096
Pubmed	Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.	CAPN7 HTT	4.09e-05	5	71	2	14981075
Pubmed	BAG3 promotes proliferation of ovarian cancer cells via post-transcriptional regulation of Skp2 expression.	CDKN1B BAG3	4.09e-05	5	71	2	28624440
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TCF7L2 GTF3C1 TJP1 BICRA SIPA1L3 CCDC85C AFF1 RPRD2 SRCIN1 PTK2 HTT SOS2	4.47e-05	1489	71	12	28611215
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	SETD1B SEMA7A CASKIN1 GRK5 PTK2 PRRC2B HTT	5.31e-05	475	71	7	31040226
Pubmed	ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.	CASKIN1 PCLO PRKAR2A SRCIN1 HTT	6.00e-05	202	71	5	33601422
Pubmed	A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.	TCF7L2 FOXC2	6.13e-05	6	71	2	17342473
Pubmed	Non-cell autonomous and non-catalytic activities of ATX in the developing brain.	TJP1 PTK2	6.13e-05	6	71	2	25788872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SPAST MAST4 TJP1 SIPA1L3 PHACTR4 BAG3 CCDC85C CBX4 GARRE1	6.32e-05	861	71	9	36931259
Pubmed	The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.	KMT2D SUPT7L AFF1 NUP35	6.77e-05	106	71	4	31024071
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CASKIN1 PCLO SRCIN1 PTK2 ADD1 HTT	7.84e-05	347	71	6	17114649
Pubmed	Lfng and Dll3 cooperate to modulate protein interactions in cis and coordinate oscillatory Notch pathway activation in the segmentation clock.	HES7 HES5	8.57e-05	7	71	2	35429490
Pubmed	A genome-wide survey on basic helix-loop-helix transcription factors in rat and mouse.	HES7 HES5	8.57e-05	7	71	2	19306043
Pubmed	Mouse models for the Wolf-Hirschhorn deletion syndrome.	ADD1 HTT	8.57e-05	7	71	2	11152656
Pubmed	Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1.	CDKN1B HES5	8.57e-05	7	71	2	19598246
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	PCLO SIPA1L3 SRCIN1 PRRC2B NUP35	8.60e-05	218	71	5	33378226
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	BOD1 KMT2D SETD1B HCFC1	1.06e-04	119	71	4	23508102
Pubmed	Comprehensive identification of phosphorylation sites in postsynaptic density preparations.	CASKIN1 PCLO SRCIN1 ADD1 PRRC2B	1.13e-04	231	71	5	16452087
Pubmed	Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2.	AFF1 HCFC1	1.14e-04	8	71	2	32479599
Pubmed	Huntingtin facilitates polycomb repressive complex 2.	CBX4 HTT	1.14e-04	8	71	2	19933700
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2D SETD1B	1.14e-04	8	71	2	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2D SETD1B	1.14e-04	8	71	2	22266653
Pubmed	The oscillation of Notch activation, but not its boundary, is required for somite border formation and rostral-caudal patterning within a somite.	HES7 HES5	1.14e-04	8	71	2	20335362
Pubmed	The murine homologues of the Huntington disease gene (Hdh) and the alpha-adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3.	ADD1 HTT	1.14e-04	8	71	2	7959767
Pubmed	JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development.	CDKN1B TJP1	1.47e-04	9	71	2	38095908
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2D SETD1B	1.47e-04	9	71	2	22665483
Pubmed	FGF signaling patterns cell fate at the interface between tendon and bone.	HES7 HES5	1.47e-04	9	71	2	31320326
Pubmed	Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination.	TJP1 PTK2	1.47e-04	9	71	2	19820184
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPGRIP1 MYPOP GTF3C1 TJP1 PCLO GRK5 SIPA1L3 YLPM1 PRRC2B NUP35 STT3B	1.56e-04	1442	71	11	35575683
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	TJP1 PHACTR4 BAG3 PRKAR2A HCFC1 NUP35 STT3B	1.61e-04	568	71	7	37774976
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	IRF2BP2 SUPT7L RPRD2 HCFC1	1.68e-04	134	71	4	25452129
Pubmed	Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.	TJP1 BAG3 HCFC1 PTK2	1.82e-04	137	71	4	37039823
Pubmed	Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.	CDKN1B HES5	1.83e-04	10	71	2	18291358
Pubmed	Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.	SETD1B HCFC1	1.83e-04	10	71	2	17998332
Pubmed	Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.	SETD1B HCFC1	1.83e-04	10	71	2	18838538
Pubmed	Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse.	AFF2 AFF1	1.83e-04	10	71	2	19000783
Pubmed	Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2.	HES7 HES5	1.83e-04	10	71	2	25733872
Pubmed	Ccdc85c encoding a protein at apical junctions of radial glia is disrupted in hemorrhagic hydrocephalus (hhy) mice.	TJP1 CCDC85C	1.83e-04	10	71	2	22056358
Pubmed	Protein phosphatase 1γ isoforms linked interactions in the brain.	PHACTR4 YLPM1 RPRD2	2.20e-04	57	71	3	23080069
Pubmed	Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development.	CDKN1B HES5	2.23e-04	11	71	2	18302773
Pubmed	Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somite.	HES7 HES5	2.23e-04	11	71	2	20346937
Pubmed	Tcf7L2 is essential for neurogenesis in the developing mouse neocortex.	TCF7L2 TJP1	2.23e-04	11	71	2	29751817
Pubmed	Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer.	HES7 HES5	2.23e-04	11	71	2	17611704
Pubmed	Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein.	CDKN1B CDC6	2.23e-04	11	71	2	15050687
Pubmed	Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis.	TJP1 FOXC2	2.23e-04	11	71	2	26839363
Pubmed	Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation.	CDKN1B FOXC2	2.68e-04	12	71	2	15342473
Pubmed	Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.	CDKN1B HES5	2.68e-04	12	71	2	25535395
Pubmed	Dll3 is expressed in developing hair cells in the mammalian cochlea.	CDKN1B HES5	2.68e-04	12	71	2	17823936
Pubmed	The period of the somite segmentation clock is sensitive to Notch activity.	HES7 HES5	2.68e-04	12	71	2	21795391
Pubmed	Expression of Notch signaling pathway genes in mouse embryos lacking beta4galactosyltransferase-1.	HES7 HES5	2.68e-04	12	71	2	16412699
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	BICRA CBX4 GARRE1 PRRC2B	2.71e-04	152	71	4	38360978
Interaction	WWTR1 interactions	KMT2D GTF3C1 TJP1 PHACTR4 NFKBIE BAG3 CCDC85C RPRD2 HCFC1 PRRC2B NUP35 HTT	2.16e-08	422	70	12	int:WWTR1
Interaction	ENTR1 interactions	BORCS6 RPGRIP1 LCA5 TJP1 SIPA1L3 CCDC85C GARRE1	4.01e-06	188	70	7	int:ENTR1
Interaction	HNF1B interactions	KMT2D TCF7L2 BICRA ATF7IP CABIN1 PRRC2B NUP35	4.30e-06	190	70	7	int:HNF1B
Interaction	WDR82 interactions	BOD1 KMT2D SETD1B GRK5 CBX4 HCFC1 HTT	9.10e-06	213	70	7	int:WDR82
Interaction	TOP3B interactions	KMT2D SETD1B ZNF48 SEMA7A ADAMTS7 BICRA CASKIN1 GRK5 SIPA1L3 HELZ2 CABIN1 HCFC1 ADCY7 CLDN23 PRRC2B HTT	3.39e-05	1470	70	16	int:TOP3B
Interaction	PAX6 interactions	IRF2BP2 KMT2D TCF7L2 GTF3C1 GAS2L2 BICRA CABIN1 PRRC2B	3.88e-05	366	70	8	int:PAX6
Interaction	VASP interactions	IRF2BP2 TJP1 SIPA1L3 PHACTR4 BAG3 CCDC85C HS1BP3	7.15e-05	294	70	7	int:VASP
Interaction	YWHAG interactions	CDKN1B LCA5 SPAST MAST4 TJP1 GRK5 SIPA1L3 PHACTR4 BAG3 CCDC85C CBX4 GARRE1 PTK2 HTT	8.34e-05	1248	70	14	int:YWHAG
Interaction	SP7 interactions	IRF2BP2 KMT2D TCF7L2 BICRA YLPM1 RPRD2 PRRC2B	8.82e-05	304	70	7	int:SP7
Interaction	PCLO interactions	SPAST PCLO CBX4 HTT	1.03e-04	70	70	4	int:PCLO
Interaction	AMPH interactions	SPAST CABIN1 PTK2 HTT	1.15e-04	72	70	4	int:AMPH
Interaction	SMG7 interactions	IRF2BP2 KMT2D YLPM1 RPRD2 GARRE1 PRRC2B NUP35	1.19e-04	319	70	7	int:SMG7
Interaction	SIAH1 interactions	CDKN1B AFF2 BAG3 AFF1 HCFC1 HTT	1.25e-04	223	70	6	int:SIAH1
Interaction	CNOT7 interactions	BAG3 GARRE1 PRRC2B HTT FOXC2	1.27e-04	140	70	5	int:CNOT7
Interaction	SETD1B interactions	BOD1 KMT2D SETD1B HCFC1	1.35e-04	75	70	4	int:SETD1B
Interaction	PPP1CA interactions	IRF2BP2 PHACTR4 YLPM1 CCDC85C PRKAR2A RPRD2 WDFY4 HCFC1 PTK2 HTT	1.38e-04	696	70	10	int:PPP1CA
Interaction	UBN1 interactions	TCF7L2 GTF3C1 TJP1 CABIN1	1.49e-04	77	70	4	int:UBN1
Interaction	NCOA6 interactions	KMT2D SETD1B HCFC1 NUP35 HTT	1.50e-04	145	70	5	int:NCOA6
Interaction	HEYL interactions	RPGRIP1 ATF7IP HTT	1.68e-04	31	70	3	int:HEYL
Interaction	YWHAB interactions	CDKN1B LCA5 MAST4 TJP1 GRK5 SIPA1L3 PHACTR4 BAG3 CCDC85C CBX4 GARRE1 HTT	1.76e-04	1014	70	12	int:YWHAB
Interaction	CLTA interactions	TCF7L2 SPAST MAST4 SIPA1L3 BAG3 WDFY4 HTT	2.14e-04	351	70	7	int:CLTA
Interaction	ASF1A interactions	IRF2BP2 KMT2D GTF3C1 BICRA CABIN1 HCFC1	2.27e-04	249	70	6	int:ASF1A
Interaction	MEF2D interactions	MEF2B KMT2D CABIN1 NUP35	2.39e-04	87	70	4	int:MEF2D
Interaction	CRYBA4 interactions	TCF7L2 GTF3C1 TJP1	2.43e-04	35	70	3	int:CRYBA4
Cytoband	22q13.33	LMF2 PANX2	1.60e-03	38	71	2	22q13.33
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF2 AFF1	3.62e-05	4	45	2	1145
GeneFamily	PDZ domain containing	MAST4 TJP1 GORASP1 PCLO SIPA1L3	3.66e-05	152	45	5	1220
GeneFamily	AF4/FMR2 family\|Super elongation complex	AFF2 AFF1	2.16e-04	9	45	2	1280
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	PHACTR4 YLPM1 HCFC1 PTK2	1.05e-03	181	45	4	694
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2D SETD1B	3.23e-03	34	45	2	487
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RPGRIP1 PCLO	3.62e-03	36	45	2	823
Coexpression	GSE17186_BLOOD_VS_CORD_BLOOD_CD21LOW_TRANSITIONAL_BCELL_UP	ATF7IP HELZ2 RPRD2 CBX4 HECA ADD1 PRRC2B	1.19e-06	200	71	7	M7195
Coexpression	GSE21033_CTRL_VS_POLYIC_STIM_DC_3H_DN	KMT2D GORASP1 GRK5 RPRD2 ADCY7 ADD1	1.69e-05	199	71	6	M7711
Coexpression	GSE40273_XBP1_KO_VS_WT_TREG_DN	SEMA7A GRK5 HELZ2 PRKAR2A WDFY4 STT3B	1.69e-05	199	71	6	M9124
Coexpression	GSE22589_HEALTHY_VS_HIV_AND_SIV_INFECTED_DC_DN	BORCS6 SPAST SETD1B ATF7IP CDC6 HCFC1	1.74e-05	200	71	6	M7796
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_7DY_DN	SETD1B BICRA PHACTR4 CACNA1I CBX4 C1orf162 GARRE1 HCFC1 ADCY7	5.24e-05	634	71	9	M40866
Coexpression	GSE21033_CTRL_VS_POLYIC_STIM_DC_6H_DN	KMT2D SEMA7A SUPT7L AFF1 RPRD2	6.85e-05	157	71	5	M7733
Coexpression	BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	TCF7L2 TJP1 ATF7IP BAG3 HS1BP3 GARRE1 HECA ADCY7 PRRC2B SOS2	7.13e-05	822	71	10	M6782
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAST4 AFF2 CAPN7 PCLO YLPM1 AFF1	3.57e-07	174	71	6	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAST4 ENHO AFF2 CAPN7 PCLO AFF1	4.08e-07	178	71	6	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	COVID-19-lung-Artery_EC\|lung / Disease (COVID-19 only), tissue and cell type	MAST4 TJP1 BAG3 HES5 GARRE1	1.26e-05	188	71	5	eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCell	COVID-19-lung-Artery_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TJP1 GRK5 BAG3 HES5 GARRE1	1.32e-05	190	71	5	07b675befcd1d0a9c90cb17b5d22323468325d51
Drug	Medrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A	TCF7L2 AFF2 PCLO CCDC85C CABIN1 HCFC1 PTK2	2.23e-06	194	70	7	4727_DN
Drug	Terbutaline hemisulfate [23031-32-5]; Down 200; 7.2uM; MCF7; HT_HG-U133A	TCF7L2 SPAST MAST4 SIPA1L3 SUPT7L PTK2 ADD1	2.47e-06	197	70	7	6240_DN
Drug	Budesonide [51333-22-3]; Down 200; 9.2uM; MCF7; HT_HG-U133A	MAST4 SIPA1L3 NFKBIE YLPM1 PRKAR2A ADCY7 SOS2	2.55e-06	198	70	7	5431_DN
Drug	NSC 97945	PTK2 ADD1 STT3B	1.51e-05	16	70	3	CID000097054
Drug	Ethacrynic acid [58-54-8]; Up 200; 13.2uM; HL60; HG-U133A	LMF2 PCLO GARRE1 ADCY7 ADD1 HTT	2.40e-05	187	70	6	1565_UP
Drug	Lithocholic acid [434-13-9]; Up 200; 10.6uM; HL60; HT_HG-U133A	BORCS6 LMF2 PCLO YLPM1 GARRE1 HCFC1	2.40e-05	187	70	6	2571_UP
Drug	Lovastatin [75330-75-5]; Up 200; 9.8uM; MCF7; HT_HG-U133A	LMF2 PRR36 PCLO CCDC85C CABIN1 ADD1	2.87e-05	193	70	6	4978_UP
Drug	Omeprazole [73590-58-6]; Down 200; 11.6uM; MCF7; HT_HG-U133A	CDK20 MAST4 SUPT7L PRKAR2A CBX4 SOS2	2.87e-05	193	70	6	2828_DN
Drug	Butylparaben [94-26-8]; Down 200; 20.6uM; MCF7; HT_HG-U133A	TCF7L2 LMF2 SIPA1L3 CACNA1I CABIN1 SOS2	2.87e-05	193	70	6	5608_DN
Drug	Iohexol [66108-95-0]; Up 200; 4.8uM; PC3; HT_HG-U133A	SEMA7A GRK5 HS1BP3 HCFC1 PTK2 PRRC2B	2.95e-05	194	70	6	4643_UP
Drug	Mephenytoin [50-12-4]; Down 200; 18.4uM; MCF7; HT_HG-U133A	CDK20 MAST4 SUPT7L PRKAR2A CABIN1 SOS2	3.04e-05	195	70	6	3580_DN
Drug	Hydroflumethiazide [135-09-1]; Down 200; 12uM; MCF7; HT_HG-U133A	CDK20 TCF7L2 MAST4 PRR36 SIPA1L3 PTK2	3.04e-05	195	70	6	1687_DN
Drug	Iproniazide phosphate [305-33-9]; Down 200; 14.4uM; PC3; HT_HG-U133A	TCF7L2 MAST4 HS1BP3 CABIN1 ADD1 HTT	3.04e-05	195	70	6	2125_DN
Drug	Corticosterone [50-22-6]; Down 200; 11.6uM; MCF7; HT_HG-U133A	AFF2 SEMA7A GRK5 CCDC85C PRKAR2A HCFC1	3.04e-05	195	70	6	4145_DN
Drug	Gemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A	MAST4 PRR36 SIPA1L3 PRKAR2A AFF1 SOS2	3.13e-05	196	70	6	5488_UP
Drug	Indapamide [26807-65-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A	TCF7L2 LMF2 PRR36 SIPA1L3 PRKAR2A SOS2	3.13e-05	196	70	6	3970_DN
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A	CDK20 MAST4 PRR36 PRKAR2A CABIN1 SOS2	3.13e-05	196	70	6	5604_DN
Drug	Clofazimine [2030-63-9]; Down 200; 8.4uM; MCF7; HT_HG-U133A	BORCS6 AFF2 ADAMTS7 AFF1 CACNA1I SOS2	3.13e-05	196	70	6	5642_DN
Drug	Deferoxamine mesylate [138-14-7]; Down 200; 6uM; MCF7; HT_HG-U133A	LMF2 MAST4 PRR36 SIPA1L3 HCFC1 SOS2	3.13e-05	196	70	6	3936_DN
Drug	Hydrochlorothiazide [58-93-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A	TCF7L2 LMF2 MAST4 YLPM1 CBX4 CABIN1	3.13e-05	196	70	6	1487_DN
Drug	Sotalol hydrochloride [959-24-0]; Down 200; 13uM; MCF7; HT_HG-U133A	BORCS6 LMF2 SEMA7A PRR36 CCDC85C PRRC2B	3.22e-05	197	70	6	4160_DN
Drug	Sulfadiazine [68-35-9]; Down 200; 16uM; PC3; HT_HG-U133A	TCF7L2 SETD1B PRR36 BICRA SUPT7L CCDC85C	3.22e-05	197	70	6	1810_DN
Drug	Streptomycin sulfate [3810-74-0]; Down 200; 2.8uM; MCF7; HT_HG-U133A	TCF7L2 LMF2 AFF2 YLPM1 CABIN1 HCFC1	3.22e-05	197	70	6	7194_DN
Drug	Benfotiamine [22457-89-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	LMF2 MAST4 PRR36 GRK5 SIPA1L3 CBX4	3.22e-05	197	70	6	3931_DN
Drug	Adiphenine hydrochloride [50-42-0]; Down 200; 11.4uM; MCF7; HT_HG-U133A	ZNF142 TCF7L2 LMF2 YLPM1 HCFC1 SOS2	3.22e-05	197	70	6	7037_DN
Drug	Alprostadil [745-65-3]; Down 200; 11.2uM; MCF7; HT_HG-U133A	CCDC85C AFF1 CABIN1 HCFC1 ADCY7 SOS2	3.22e-05	197	70	6	7358_DN
Drug	Pentolinium bitartrate [52-62-0]; Up 200; 7.4uM; PC3; HT_HG-U133A	LMF2 SIPA1L3 YLPM1 CBX4 CABIN1 SOS2	3.31e-05	198	70	6	7375_UP
Drug	Hydroxytacrine maleate (R,S) [118909-22-1]; Down 200; 12.2uM; MCF7; HT_HG-U133A	BORCS6 TCF7L2 SIPA1L3 CCDC85C GARRE1 SOS2	3.31e-05	198	70	6	3292_DN
Drug	Ribostamycin sulfate salt [53797-35-6]; Up 200; 7.2uM; MCF7; HT_HG-U133A	LMF2 SETD1B MAST4 PRR36 HCFC1 SOS2	3.31e-05	198	70	6	6765_UP
Drug	Cinnarizine [298-57-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	TCF7L2 BICRA NFKBIE RPRD2 CABIN1 PRRC2B	3.31e-05	198	70	6	7174_DN
Drug	Liothyronine [6893-02-3]; Up 200; 6.2uM; MCF7; HT_HG-U133A	BORCS6 LMF2 AFF2 CCDC85C CACNA1I SOS2	3.31e-05	198	70	6	4947_UP
Drug	(S)-propranolol hydrochloride [4199-10-4]; Down 200; 13.6uM; PC3; HT_HG-U133A	LMF2 MAST4 GTF3C1 GRK5 PRKAR2A CABIN1	3.31e-05	198	70	6	6343_DN
Drug	Corynanthine hydrochloride [66634-44-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A	CDK20 ZNF142 SPAST MAST4 ADCY7 SOS2	3.31e-05	198	70	6	2786_DN
Drug	Nitrarine dihydrochloride [20069-05-0]; Down 200; 10.6uM; MCF7; HT_HG-U133A	LMF2 MAST4 CCDC85C PRKAR2A GARRE1 ADCY7	3.31e-05	198	70	6	6043_DN
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	MAST4 GRK5 SIPA1L3 CCDC85C HCFC1 SOS2	3.31e-05	198	70	6	3882_DN
Drug	Sulfanilamide [63-74-1]; Up 200; 23.2uM; MCF7; HT_HG-U133A	TCF7L2 LMF2 PRR36 CACNA1I ADCY7 SOS2	3.40e-05	199	70	6	3449_UP
Drug	Nalidixic acid sodium salt hydrate; Down 200; 14.6uM; MCF7; HT_HG-U133A	TCF7L2 PRR36 SIPA1L3 CABIN1 HCFC1 SOS2	3.40e-05	199	70	6	4691_DN
Drug	Meptazinol hydrochloride [59263-76-2]; Up 200; 14.8uM; MCF7; HT_HG-U133A	TCF7L2 SEMA7A PCLO CACNA1I CABIN1 SOS2	3.40e-05	199	70	6	4774_UP
Drug	Pralidoxime chloride [51-15-0]; Up 200; 23.2uM; PC3; HT_HG-U133A	CDK20 SEMA7A GRK5 HCFC1 ADD1 SOS2	3.50e-05	200	70	6	6283_UP
Drug	estradiol, USP; Down 200; 0.01uM; PC3; HG-U133A	ZNF142 SETD1B MAST4 AFF1 CDC6 HTT	3.50e-05	200	70	6	665_DN
Drug	Tinidazole [19387-91-8]; Down 200; 16.2uM; MCF7; HT_HG-U133A	LMF2 MAST4 SEMA7A PRR36 SIPA1L3 CCDC85C	3.50e-05	200	70	6	3896_DN
Drug	7B-forskolin	SUPT7L PRKAR2A ADCY7	6.88e-05	26	70	3	CID000130638
Drug	Strophantine octahydrate [11018-89-6]; Up 200; 5.4uM; HL60; HT_HG-U133A	TCF7L2 ATF7IP NFKBIE CBX4 HCFC1	1.99e-04	174	70	5	1302_UP
Drug	Phenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; PC3; HT_HG-U133A	TCF7L2 MAST4 GRK5 YLPM1 PTK2	2.16e-04	177	70	5	4652_DN
Drug	Calpain inhibitor I	CDKN1B GORASP1 CAPN7 SUPT7L NFKBIE PTK2	2.22e-04	280	70	6	CID000004332
Drug	Phenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	TCF7L2 MAST4 YLPM1 CCDC85C SOS2	2.52e-04	183	70	5	5613_DN
Drug	Zuclopenthixol hydrochloride [633-59-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A	CDK20 BORCS6 LMF2 CAPN7 GRK5	2.52e-04	183	70	5	4843_UP
Drug	Lycorine hydrochloride [2188-68-3]; Down 200; 12.4uM; MCF7; HT_HG-U133A	MAST4 CBX4 CABIN1 HCFC1 ADCY7	2.71e-04	186	70	5	6051_DN
Drug	LY 294002; Up 200; 10uM; MCF7; HT_HG-U133A	LMF2 PCLO SIPA1L3 HECA SOS2	2.78e-04	187	70	5	5233_UP
Drug	Phenoxybenzamine hydrochloride [63-92-3]; Down 200; 11.8uM; MCF7; HT_HG-U133A	TCF7L2 SPAST GRK5 SIPA1L3 PRKAR2A	2.92e-04	189	70	5	5248_DN
Drug	wortmannin; Down 200; 1uM; MCF7; HT_HG-U133A_EA	TCF7L2 SUPT7L CCDC85C CDC6 SOS2	2.92e-04	189	70	5	869_DN
Drug	Acacetin [480-44-4]; Down 200; 14uM; HL60; HT_HG-U133A	OCEL1 PRKAR2A AFF1 HTT SOS2	2.99e-04	190	70	5	2189_DN
Drug	17-DMAG; Up 200; 0.1uM; MCF7; HT_HG-U133A	LMF2 SIPA1L3 BAG3 YLPM1 ADCY7	3.07e-04	191	70	5	6933_UP
Drug	Mesalamine [89-57-6]; Down 200; 26.2uM; HL60; HT_HG-U133A	TCF7L2 BICRA CAPN7 HTT SOS2	3.14e-04	192	70	5	6162_DN
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	LMF2 SETD1B MAST4 SIPA1L3 YLPM1	3.14e-04	192	70	5	6958_UP
Drug	2-propylpentanoic acid; Up 200; 1000uM; MCF7; HT_HG-U133A	BORCS6 PRR36 GRK5 CCDC85C HECA	3.14e-04	192	70	5	5206_UP
Drug	Hydrastinine hydrochloride [4884-68-8]; Up 200; 16.4uM; MCF7; HT_HG-U133A	SEMA7A ADAMTS7 GRK5 CACNA1I SOS2	3.22e-04	193	70	5	2283_UP
Drug	Mebeverine hydrochloride [2753-45-9]; Up 200; 8.6uM; PC3; HT_HG-U133A	LMF2 MAST4 SIPA1L3 CCDC85C CABIN1	3.22e-04	193	70	5	7147_UP
Drug	Thiamine hydrochloride [67-03-8]; Down 200; 11.8uM; MCF7; HT_HG-U133A	CDK20 TCF7L2 MAST4 GRK5 SIPA1L3	3.22e-04	193	70	5	2894_DN
Drug	Acetaminophen [103-90-2]; Down 200; 26.4uM; MCF7; HT_HG-U133A	TCF7L2 PRR36 SUPT7L CCDC85C SOS2	3.30e-04	194	70	5	5384_DN
Drug	Norcyclobenzaprine [303-50-4]; Down 200; 15.4uM; HL60; HT_HG-U133A	BORCS6 TCF7L2 LMF2 PRKAR2A SOS2	3.30e-04	194	70	5	2469_DN
Drug	Neomycin sulfate [1405-10-3]; Down 200; 4.2uM; MCF7; HT_HG-U133A	TCF7L2 LMF2 MAST4 CABIN1 HCFC1	3.30e-04	194	70	5	7221_DN
Drug	Altretamine [654-05-6]; Down 200; 19uM; MCF7; HT_HG-U133A	SIPA1L3 CABIN1 HCFC1 PRRC2B SOS2	3.30e-04	194	70	5	6467_DN
Drug	Cyclosporin A [59865-13-3]; Down 200; 3.4uM; MCF7; HT_HG-U133A	LMF2 PCLO CCDC85C HCFC1 SOS2	3.30e-04	194	70	5	4411_DN
Drug	troglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	CDK20 SPAST SEMA7A PRKAR2A SOS2	3.30e-04	194	70	5	5229_UP
Drug	Pentamidine isethionate [140-64-7]; Up 200; 6.8uM; PC3; HT_HG-U133A	CDK20 PRR36 CCDC85C AFF1 HCFC1	3.30e-04	194	70	5	4573_UP
Drug	Danazol [17230-88-5]; Down 200; 11.8uM; PC3; HG-U133A	SETD1B RPRD2 ADD1 PRRC2B HTT	3.30e-04	194	70	5	1954_DN
Drug	ICI 182,780; Down 200; 0.01uM; HL60; HT_HG-U133A	TCF7L2 BICRA CABIN1 GARRE1 HCFC1	3.30e-04	194	70	5	1179_DN
Drug	Zomepirac sodium salt [64092-48-4]; Down 200; 12.8uM; MCF7; HT_HG-U133A	CDK20 SIPA1L3 CCDC85C HS1BP3 SOS2	3.30e-04	194	70	5	3454_DN
Drug	Sertaconazole nitrate [99592-39-9]; Down 200; 8uM; MCF7; HT_HG-U133A	LMF2 SPAST MAST4 GRK5 SIPA1L3	3.30e-04	194	70	5	6811_DN
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	CDK20 TCF7L2 CCDC85C ADCY7 SOS2	3.37e-04	195	70	5	4358_DN
Drug	radicicol; Up 200; 0.1uM; PC3; HG-U133A	GRK5 BAG3 AFF1 ADCY7 HTT	3.37e-04	195	70	5	449_UP
Drug	5140203; Down 200; 15uM; MCF7; HT_HG-U133A_EA	CDK20 LMF2 PRR36 YLPM1 CABIN1	3.37e-04	195	70	5	908_DN
Drug	5213008; Down 200; 18uM; MCF7; HT_HG-U133A_EA	TCF7L2 LMF2 PRR36 PHACTR4 CABIN1	3.37e-04	195	70	5	898_DN
Drug	Progesterone [57-83-0]; Up 200; 12.8uM; HL60; HT_HG-U133A	BORCS6 TJP1 PCLO CACNA1I SOS2	3.37e-04	195	70	5	2426_UP
Drug	Securinine [5610-40-2]; Down 200; 18.4uM; MCF7; HT_HG-U133A	CDK20 MAST4 YLPM1 CCDC85C HS1BP3	3.37e-04	195	70	5	3470_DN
Drug	Ethionamide [536-33-4]; Down 200; 24uM; MCF7; HT_HG-U133A	CDK20 SEMA7A PCLO CCDC85C SOS2	3.37e-04	195	70	5	4418_DN
Drug	Cholecalciferol [67-97-0]; Up 200; 10.4uM; MCF7; HT_HG-U133A	SEMA7A GRK5 PHACTR4 CACNA1I SOS2	3.37e-04	195	70	5	3298_UP
Drug	Nabumetone [42924-53-8]; Down 200; 17.6uM; MCF7; HT_HG-U133A	TCF7L2 MAST4 PRR36 NFKBIE SOS2	3.37e-04	195	70	5	5428_DN
Drug	Ticlopidine hydrochloride [53885-35-1]; Down 200; 13.4uM; MCF7; HT_HG-U133A	LMF2 PRR36 SIPA1L3 CCDC85C SOS2	3.37e-04	195	70	5	4155_DN
Drug	Bicuculline (+) [485-49-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A	LMF2 AFF2 GRK5 CABIN1 HCFC1	3.37e-04	195	70	5	2796_UP
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; PC3; HT_HG-U133A	SETD1B SUPT7L PRKAR2A HS1BP3 SOS2	3.37e-04	195	70	5	3714_DN
Drug	Tacrine hydrochloride hydrate [1684-40-8]; Up 200; 15.8uM; MCF7; HT_HG-U133A	SETD1B SUPT7L CBX4 CABIN1 PRRC2B	3.37e-04	195	70	5	5297_UP
Drug	Ethacrynic acid [58-54-8]; Up 200; 13.2uM; MCF7; HT_HG-U133A	LMF2 ADAMTS7 PCLO AFF1 SOS2	3.37e-04	195	70	5	3181_UP
Drug	Naphazoline hydrochloride [550-99-2]; Down 200; 16.2uM; PC3; HG-U133A	MAST4 GTF3C1 SIPA1L3 CDC6 HCFC1	3.37e-04	195	70	5	1886_DN
Drug	Probucol [23288-49-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A	PRR36 SIPA1L3 PRKAR2A GARRE1 SOS2	3.37e-04	195	70	5	5626_DN
Drug	AC1L1IZ2	GTF3C1 PRKAR2A PANX2 ADCY7 PTK2 STT3B	3.45e-04	304	70	6	CID000004795
Drug	Niridazole [61-57-4]; Down 200; 18.6uM; HL60; HT_HG-U133A	TCF7L2 PRKAR2A CABIN1 HTT SOS2	3.45e-04	196	70	5	2440_DN
Drug	Phenylpropanolamine hydrochloride [154-41-6]; Down 200; 21.4uM; MCF7; HT_HG-U133A	CDK20 BICRA SIPA1L3 ADCY7 SOS2	3.45e-04	196	70	5	3217_DN
Drug	Dobutamine hydrochloride [49745-95-1]; Down 200; 11.8uM; PC3; HT_HG-U133A	GRK5 SIPA1L3 CCDC85C HS1BP3 CABIN1	3.45e-04	196	70	5	6286_DN
Drug	Pirenzepine dihydrochloride [29868-97-1]; Down 200; 9.4uM; MCF7; HT_HG-U133A	TCF7L2 BICRA SUPT7L HCFC1 PRRC2B	3.45e-04	196	70	5	7226_DN
Drug	radicicol; Up 200; 0.1uM; SKMEL5; HG-U133A	GTF3C1 BICRA BAG3 CCDC85C AFF1	3.45e-04	196	70	5	493_UP
Drug	Vancomycin hydrochloride [1404-93-9]; Down 200; 2.6uM; MCF7; HT_HG-U133A	LMF2 CCDC85C PRKAR2A HCFC1 ADCY7	3.45e-04	196	70	5	4423_DN
Drug	Acetazolamide [59-66-5]; Up 200; 18uM; MCF7; HT_HG-U133A	BORCS6 ADAMTS7 CCDC85C AFF1 SOS2	3.45e-04	196	70	5	1686_UP
Drug	Hydrastinine hydrochloride [4884-68-8]; Down 200; 16.4uM; PC3; HT_HG-U133A	LMF2 SPAST PHACTR4 CABIN1 PRRC2B	3.45e-04	196	70	5	2119_DN
Drug	Hecogenin [467-55-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A	TCF7L2 SPAST MAST4 YLPM1 HCFC1	3.45e-04	196	70	5	7175_DN
Drug	Suramin sodium salt; Down 200; 10uM; MCF7; HT_HG-U133A	CDK20 TCF7L2 NFKBIE GARRE1 SOS2	3.45e-04	196	70	5	7496_DN
Drug	Imipramine hydrochloride [113-52-0]; Down 200; 12.6uM; MCF7; HT_HG-U133A	MAST4 PRR36 PHACTR4 CABIN1 PTK2	3.45e-04	196	70	5	1685_DN
Drug	Sulfadimethoxine [122-11-2]; Up 200; 12.8uM; MCF7; HT_HG-U133A	SETD1B SEMA7A GRK5 AFF1 HCFC1	3.45e-04	196	70	5	4724_UP
Drug	Aminophylline [317-34-0]; Down 200; 9.6uM; PC3; HT_HG-U133A	LMF2 GRK5 CCDC85C CABIN1 PRRC2B	3.45e-04	196	70	5	6295_DN
Disease	household income	TCF7L2 MAST4 ATF7IP CACNA1I ADD1 HTT	7.91e-05	304	69	6	EFO_0009695
Disease	cortical thickness	LMAN1L IRF2BP2 TCF7L2 MAST4 ADAMTS7 YLPM1 PRKAR2A AFF1 FOXC2 SOS2	2.52e-04	1113	69	10	EFO_0004840
Disease	Antihypertensive use measurement	LMAN1L TCF7L2 ENHO PHACTR4 BAG3	3.96e-04	265	69	5	EFO_0009927
Disease	lung small cell carcinoma (is_marker_for)	CDKN1B PTK2	6.33e-04	16	69	2	DOID:5409 (is_marker_for)
Disease	Leber congenital amaurosis	RPGRIP1 LCA5	6.33e-04	16	69	2	cv:C0339527
Disease	intellectual disability (implicated_via_orthology)	BOD1 MEF2B ATF7IP	7.33e-04	75	69	3	DOID:1059 (implicated_via_orthology)
Disease	Hydrops Fetalis	FOXC2 SOS2	8.98e-04	19	69	2	C0020305
Disease	hydrocephalus (implicated_via_orthology)	CCDC85C ADD1	8.98e-04	19	69	2	DOID:10908 (implicated_via_orthology)
Disease	sex interaction measurement, cerebral amyloid angiopathy	SRCIN1 HS1BP3	1.10e-03	21	69	2	EFO_0006790, EFO_0008343
Disease	Nystagmus	MAST4 AFF2	1.10e-03	21	69	2	HP_0000639
Disease	Leber Congenital Amaurosis	RPGRIP1 LCA5	1.21e-03	22	69	2	C0339527
Disease	Sezary Syndrome	CDKN1B KMT2D	1.82e-03	27	69	2	C0036920
Disease	type 2 diabetes mellitus (implicated_via_orthology)	TCF7L2 AFF2 AFF1	1.93e-03	105	69	3	DOID:9352 (implicated_via_orthology)
Disease	unipolar depression, irritable bowel syndrome	TCF7L2 PCLO	1.96e-03	28	69	2	EFO_0000555, EFO_0003761
Disease	lung small cell carcinoma (is_implicated_in)	KMT2D PTK2	1.96e-03	28	69	2	DOID:5409 (is_implicated_in)
Disease	longevity, healthspan, parental longevity	TCF7L2 HTT	2.10e-03	29	69	2	EFO_0004300, EFO_0007796, EFO_0009762

Protein segments in the cluster

Peptide	Gene	Start	Entry
HHRPDPHPPAPGKKK	nan	41	A8MWP4
PHPPAPGKKKSSPVG	nan	46	A8MWP4
PIPQRLGGPAPKAHP	CDK20	301	Q8IZL9
CPEKAPPPQKPSHEG	ENHO	56	Q6UWT2
PPRGRNKATAHKPAP	AFF2	666	P51816
PPPSQHLPRPKGDAA	ADCY7	461	P51828
PPRPPKGACKVPAQE	CDKN1B	91	P46527
GPAKPPAHRPCGAQP	ADAMTS7	1506	Q9UKP4
REKSAPEPPPPGKHS	CPXM2	91	Q8N436
PRPPCQPQPGPHKAK	OCEL1	96	Q9H607
PIGAIPKGHKPRPHP	OCEL1	131	Q9H607
KTPKNGPPPCPRLGH	HCFC1	126	P51610
KRAHGTPPPVSPKPP	CASKIN1	1261	Q8WXD9
AKPPSPGAPALHVPA	CASKIN1	1326	Q8WXD9
PGAPALHVPAKPPRA	CASKIN1	1331	Q8WXD9
RPPNKPQKGPSHDLP	HECA	226	Q9UBI9
AKAAAKAPRPPGQPP	LMAN1L	441	Q9HAT1
PCTHPPGPVKEPQEK	NFKBIE	186	O00221
PLLPPGPHKAPDGKA	CCDC85C	226	A6NKD9
HEKSQPGPAKPPAQP	PCLO	321	Q9Y6V0
HHQAPRKPSPKGLPN	LCA5	61	Q86VQ0
AHLKEPPPAASKGAP	FOXC2	181	Q99958
KQPPIPPPKPAHRNS	PHACTR4	256	Q8IZ21
RIPTQPPSYHKKPPG	GORASP1	201	Q9BQQ3
RPAAPKAGPPGLVHP	MEF2B	171	Q02080
PGPAVAEEPLHRPKK	HTT	76	P42858
PRKPAVPPKAGPAEA	HS1BP3	341	Q53T59
LSSRHKNPAPPEGKP	BORCS6	106	Q96GS4
PPEGHPGKPEPSRAK	CABIN1	2111	Q9Y6J0
VKPKPPPVRAHFPLG	CAPN7	166	Q9Y6W3
PGSFLKPPAPPVQHE	GAS2L2	281	Q8NHY3
KKAAVPAPPPEPEGQ	BOD1	161	Q96IK1
APAPAKPGPHAKEPR	CACNA1I	471	Q9P0X4
PPPPAHKAAPKGFKA	GARRE1	1041	O15063
QPHSKERAGKPPPPG	CBX4	131	O00257
NTPHLPPCSPPKQGK	CDC6	66	Q99741
KKRHEHPPNPPVSPG	ATF7IP	661	Q6VMQ6
KTNHKDGPGEARPPP	MAST4	2041	O15021
KGKDPAPAQPPPARK	MAST4	2561	O15021
HPPPEPGPDRVADAK	PRKAR2A	61	P13861
ERSPHPPQEVKDPPG	CCDC192	256	P0DO97
KGNPIHARGKVPPHP	HELZ2	761	Q9BYK8
DLNRNHPPEPPKKGL	GRK5	536	P34947
PPPHRQDGAPKAPLP	HES7	201	Q9BYE0
TPPKPGEAEAPPKHP	BAG3	406	O95817
GTVDHPPPAAPERKP	BICRA	1361	Q9NZM4
KPQAPDPHSDPPAKL	C1orf162	96	Q8NEQ5
KEAALAHAAPPPPPG	RPRD2	1246	Q5VT52
AKEKQPPPPAHRGPA	IRF2BP2	256	Q7Z5L9
DGQHRPPPAQHRKPK	CLDN23	226	Q96B33
APAPAPPPAPDKKHA	PANX2	496	Q96RD6
QPVVPAHKDKSGAPP	NUP35	76	Q8NFH5
HTAGAPVPEKPKRGP	RPGRIP1	151	Q96KN7
PPPLPPRKKFDHDAS	SOS2	1146	Q07890
KPGNLSRPPPVVVPH	LMF2	486	Q9BU23
APPKKPPRPGAPGHL	PTK2	871	Q05397
GTPRAPAHPSQPKPK	PRR36	261	Q9H6K5
AKAPRPAKPHKPPGS	SIPA1L3	1326	O60292
PKKRHEDLVPPAGSP	SETD1B	1646	Q9UPS6
AGPAPPPESPHKRNL	SPAST	36	Q9UBP0
DPPLHQPSANKPKPP	SUPT7L	36	O94864
PAAPAKEPKAPGAAP	HES5	126	Q5TA89
PRAPPEAPHPGKRSC	AFF1	571	P51825
QKEKSPPDQPAVPHP	ADD1	596	P35611
PPPPLAGDKPHKCPE	ZNF48	441	Q96MX3
PPKAPHGQKAAPRTE	SRCIN1	966	Q9C0H9
AHKAAGGAAPPKPAP	STT3B	41	Q8TCJ2
PADVDPKTGIPRPPH	TCF7L2	221	Q9NQB0
KPHPARTAAGKPLPG	WDFY4	2816	Q6ZS81
RKAPDPQPPPRKLHG	PRRC2B	446	Q5JSZ5
EPHKECPNPKPDKAP	SEMA7A	536	O75326
SHQPPPAPRVEKKPE	YLPM1	1801	P49750
LRPEAQPHPSAGPKP	TJP1	1171	Q07157
PKKHHLDPVPPAGNS	ZNF142	996	P52746
HPLKKQPPSFPGAAE	GTF3C1	526	Q12789
LHKPPRPQPPEVAFK	KMT2D	2466	O14686
GDRFVIPPHPKVPAP	KIAA1522	596	Q9P206
APLPPHDSPPHKRRK	MYPOP	371	Q86VE0