Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cytoplasmic region	DNAH3 GUCY1B1 HAP1 DTNBP1 DNAI3 HYDIN MAPK8IP3 AP3S2	1.72e-05	360	66	8	GO:0099568
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	DNAH3 HAP1 DTNBP1 DNAI3 HYDIN MAPK8IP3 AP3S2	6.25e-05	317	66	7	GO:0032838
GeneOntologyCellularComponent	axon cytoplasm	HAP1 DTNBP1 MAPK8IP3 AP3S2	6.34e-05	68	66	4	GO:1904115
GeneOntologyCellularComponent	growth cone	TAOK2 STX3 HAP1 GRIN1 DTNBP1 MAPK8IP3	1.23e-04	245	66	6	GO:0030426
GeneOntologyCellularComponent	site of polarized growth	TAOK2 STX3 HAP1 GRIN1 DTNBP1 MAPK8IP3	1.47e-04	253	66	6	GO:0030427
GeneOntologyCellularComponent	synaptic cleft	ADGRB3 LAMA2 GRIN1	1.53e-04	33	66	3	GO:0043083
GeneOntologyCellularComponent	neuron projection cytoplasm	HAP1 DTNBP1 MAPK8IP3 AP3S2	4.07e-04	110	66	4	GO:0120111
GeneOntologyCellularComponent	inner dynein arm	DNAH3 DNAI3	4.35e-04	10	66	2	GO:0036156
GeneOntologyCellularComponent	presynaptic active zone	STX3 GUCY1B1 GRIN1 STX1B	1.03e-03	141	66	4	GO:0048786
Domain	SNO	SBNO1 SBNO2	1.27e-05	2	67	2	IPR026741
Domain	SBNO_Helicase_C_dom	SBNO1 SBNO2	1.27e-05	2	67	2	IPR026937
Domain	Helicase_C_4	SBNO1 SBNO2	1.27e-05	2	67	2	PF13871
Domain	ARM-type_fold	RIF1 DOCK9 NUP188 HUWE1 AP4B1 HEATR3 KPNA1	2.08e-04	339	67	7	IPR016024
Domain	SynN	STX3 STX1B	4.49e-04	9	67	2	SM00503
Domain	Syntaxin	STX3 STX1B	6.83e-04	11	67	2	PF00804
Domain	Syntaxin_N	STX3 STX1B	8.18e-04	12	67	2	IPR006011
Domain	Syntaxin/epimorphin_CS	STX3 STX1B	1.47e-03	16	67	2	IPR006012
Domain	SYNTAXIN	STX3 STX1B	1.47e-03	16	67	2	PS00914
Domain	SNARE	STX3 STX1B	2.55e-03	21	67	2	PF05739
Domain	t_SNARE	STX3 STX1B	2.80e-03	22	67	2	SM00397
Domain	ARM-like	RIF1 HUWE1 AP4B1 HEATR3 KPNA1	2.83e-03	270	67	5	IPR011989
Domain	T_SNARE	STX3 STX1B	3.90e-03	26	67	2	PS50192
Domain	T_SNARE_dom	STX3 STX1B	4.84e-03	29	67	2	IPR000727
Pubmed	LTP requires a unique postsynaptic SNARE fusion machinery.	STX3 GRIN1 STX1B	1.48e-06	12	67	3	23395379
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	TAOK2 ACADVL ACAT1 GUCY1B1 DOCK9 ATG2B ADGRB3 GRIN1 HUWE1 STX1B RYR2 MAPK8IP3	1.64e-06	1139	67	12	36417873
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RIF1 PBRM1 SBNO1 ACAT1 CCDC47 SUPT6H MTR NUP188 HUWE1 MDH1 THOC2 NONO DDX1	2.80e-06	1425	67	13	30948266
Pubmed	Study of Strawberry Notch homolog 1 and 2 expression in human glioblastoma.	SBNO1 SBNO2	3.66e-06	2	67	2	36695974
Pubmed	A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes.	RC3H1 RYR2	3.66e-06	2	67	2	25193700
Pubmed	Role for RIF1-interacting partner DDX1 in BLM recruitment to DNA double-strand breaks.	RIF1 DDX1	3.66e-06	2	67	2	28544931
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	TGM1 RIF1 TOX4 PBRM1 THOC2 NONO	7.82e-06	244	67	6	29884807
Pubmed	Cellular and circuit models of increased resting-state network gamma activity in schizophrenia.	GRIN1 DTNBP1	1.10e-05	3	67	2	26577758
Pubmed	Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway.	HAP1 MAPK8IP3	1.10e-05	3	67	2	34014261
Pubmed	The BAH domain of BAF180 is required for PCNA ubiquitination.	PBRM1 USP1	1.10e-05	3	67	2	26117423
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	RIF1 HUWE1 COPS5 HEATR3 SBNO2	1.20e-05	153	67	5	26365490
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	RIF1 TTC28 CCDC47 ATG2B MTR RNF41 HUWE1 KPNA1	2.14e-05	606	67	8	36538041
Pubmed	A mouse homologue of Strawberry Notch is transcriptionally regulated by Reelin signal.	SBNO1 SBNO2	2.19e-05	4	67	2	17045962
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	S100P ACADVL ACAT1 AKAP13 HUWE1 MDH1 NONO HYDIN DDX1	2.40e-05	807	67	9	30575818
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RIF1 PBRM1 ACADVL ACAT1 SUPT6H NUP188 HUWE1 THOC2 NONO DDX1	2.54e-05	1024	67	10	24711643
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	RIF1 CCDC47 MTR NUP188 HUWE1 THOC2 USP1 NONO COPS5 DDX1 KPNA1	2.64e-05	1257	67	11	37317656
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	DNAH3 PBRM1 SUPT6H ADGRB3 HKDC1 THOC2 NONO DDX1 KPNA1	3.49e-05	847	67	9	35235311
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	FREM2 TTC28 MTR AKAP13 AP4B1 HEATR3 DDX1 SBNO2	3.52e-05	650	67	8	38777146
Pubmed	The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.	STX3 PBRM1 HUWE1	3.58e-05	33	67	3	22357600
Pubmed	Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives.	EGR2 LAMA2	3.64e-05	5	67	2	12900932
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	S100P XIRP2 AGA DOCK9 RUFY1 COPS5 HYDIN	4.84e-05	497	67	7	36774506
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TTC28 DOCK9 MYT1 MAPK8IP3	5.00e-05	104	67	4	10470851
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	TBXA2R ZNF713 STX3 EGR2 LAMA2 GRIN1 ODC1 HYDIN	5.15e-05	686	67	8	29987050
Pubmed	Jab1 regulates Schwann cell proliferation and axonal sorting through p27.	LAMA2 COPS5	5.46e-05	6	67	2	24344238
Pubmed	ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2.	TOX4 NONO DDX1	5.49e-05	38	67	3	30629181
Pubmed	Rho-associated protein kinase-dependent moesin phosphorylation is required for PD-L1 stabilization in breast cancer.	TGM1 ACAT1 HUWE1 MDH1 NONO	7.40e-05	224	67	5	32941674
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	RIF1 ACADVL SBNO1 CCDC47 SUPT6H AKAP13 HUWE1 MDH1 NONO DDX1 KPNA1	7.69e-05	1415	67	11	28515276
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	TTC28 ACADVL DOCK9 RUFY1 KPNA1	8.38e-05	230	67	5	35449600
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TOX4 TTC28 ATG2B HUWE1 THOC2 RUFY1 NONO	9.02e-05	549	67	7	38280479
Pubmed	A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells.	RIF1 TOX4 CCDC47 NONO	9.02e-05	121	67	4	22412018
Pubmed	FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act in Concert to Impair Clearing of Protein Aggregates and Autophagy.	ACAT1 MDH1 NONO COPS5 DDX1	1.19e-04	248	67	5	32963011
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	RIF1 TOX4 HUWE1 NONO COPS5 DDX1 KPNA1	1.29e-04	582	67	7	20467437
Pubmed	Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS.	TBXA2R GRIN1	1.30e-04	9	67	2	21491143
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	TAOK2 RIF1 HUWE1 THOC2 NONO DDX1 KPNA1	1.31e-04	583	67	7	29844126
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	TTC28 SUPT6H MTR HUWE1 RUFY1 NONO DDX1	1.38e-04	588	67	7	38580884
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	S100P RIF1 PBRM1 SBNO1 ACAT1 SUPT6H MDH1 THOC2 DDX1	1.38e-04	1014	67	9	32416067
Pubmed	Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.	MTR GRIN1 DTNBP1	1.41e-04	52	67	3	19328558
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TOX4 TTC28 ATG2B HUWE1 MDH1 RUFY1	1.56e-04	418	67	6	34709266
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	LAMA2 RYR2	1.63e-04	10	67	2	18434328
Pubmed	Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.	TOX4 PBRM1 THOC2 NONO DDX1	1.80e-04	271	67	5	32433965
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	RIF1 PBRM1 SUPT6H NONO KPNA1	1.83e-04	272	67	5	31010829
Pubmed	Identification of new high affinity targets for Roquin based on structural conservation.	RC3H1 DDX1	1.99e-04	11	67	2	30295819
Pubmed	E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.	USP1 COPS5	1.99e-04	11	67	2	36805027
Pubmed	Ribosomal protein L12 uses a distinct nuclear import pathway mediated by importin 11.	HUWE1 KPNA1	1.99e-04	11	67	2	11809816
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	TOX4 PBRM1 ACADVL ACAT1 CCDC47 HUWE1 THOC2 NONO DDX1 KPNA1	2.05e-04	1318	67	10	30463901
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	RIF1 SUPT6H NUP188 HUWE1 THOC2 NONO DDX1	2.27e-04	638	67	7	33239621
Pubmed	K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation.	RNF41 ZAP70	2.38e-04	12	67	2	26390156
Pubmed	Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.	HAP1 HEATR3	2.38e-04	12	67	2	22960999
Pubmed	Genome-wide association study of height and body mass index in Australian twin families.	HHIP LAMA2	2.38e-04	12	67	2	20397748
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	PBRM1 TTC28 ATG2B HUWE1 MDH1 THOC2 PRDM15	2.42e-04	645	67	7	25281560
Pubmed	The functional interactome landscape of the human histone deacetylase family.	HHIP RIF1 ATG2B HUWE1 KPNA1	2.43e-04	289	67	5	23752268
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	RIF1 ACAT1 RC3H1 NUP188 NONO DDX1	2.53e-04	457	67	6	32344865
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RIF1 PBRM1 ACAT1 SUPT6H NUP188 HUWE1 THOC2	2.61e-04	653	67	7	22586326
Pubmed	Glutamatergic Dysfunction and Synaptic Ultrastructural Alterations in Schizophrenia and Autism Spectrum Disorder: Evidence from Human and Rodent Studies.	GRIN1 DTNBP1	2.81e-04	13	67	2	33374598
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	PBRM1 TTC28 SUPT6H HUWE1 IQCD HYDIN	2.90e-04	469	67	6	27634302
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	ACAT1 CCDC47 RC3H1 HUWE1 NONO DDX1	2.90e-04	469	67	6	37314180
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	TOX4 ACADVL ACAT1 HKDC1 HUWE1 NONO DDX1	2.92e-04	665	67	7	30457570
Pubmed	Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system.	LAMA2 GRIN1	3.28e-04	14	67	2	19240213
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	PBRM1 HUWE1 THOC2 NONO DDX1 KPNA1	3.51e-04	486	67	6	30940648
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	ACAT1 HUWE1 MDH1 NONO COPS5 KPNA1	3.86e-04	495	67	6	28581483
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	XIRP2 SUPT6H DOCK9 LAMA2 DTNBP1 USP1	3.95e-04	497	67	6	23414517
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	TTC28 EGR2 FKBP9 HUWE1 DDX1	4.15e-04	325	67	5	36168628
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RIF1 PBRM1 AKAP13 HUWE1 THOC2 NONO	4.20e-04	503	67	6	16964243
Pubmed	Interactome analysis of Bag-1 isoforms reveals novel interaction partners in endoplasmic reticulum-associated degradation.	S100P ACAT1 MDH1 NONO DDX1	4.27e-04	327	67	5	34428256
Pubmed	Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.	NONO DDX1	4.31e-04	16	67	2	16230076
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	SUPT6H NONO COPS5 DDX1	4.39e-04	183	67	4	36129980
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	ACADVL ACAT1 LAMA2 MDH1 RYR2	4.51e-04	331	67	5	29199018
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	RIF1 PBRM1 HUWE1 NONO DDX1	4.58e-04	332	67	5	32786267
Pubmed	A genome wide association study identifies common variants associated with lipid levels in the Chinese population.	USP1 RYR2	4.88e-04	17	67	2	24386095
Pubmed	Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma.	SUPT6H USP1	4.88e-04	17	67	2	36352191
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	TAOK2 RIF1 TOX4 SBNO1 NUP188	5.17e-04	341	67	5	32971831
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	TTC28 GUCY1B1 CCDC47 MTR AKAP13 HUWE1 USP1	5.22e-04	733	67	7	34672954
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	FREM2 DNAH3 AKAP13 GRIN1 NUP188 HUWE1 HEATR3	5.34e-04	736	67	7	29676528
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	STX3 SUPT6H MYT1 AKAP13 HUWE1 PRDM15 COPS5 SBNO2 MAPK8IP3 KPNA1	5.38e-04	1489	67	10	28611215
Pubmed	BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2.	GRIN1 STX1B	5.48e-04	18	67	2	12588844
Pubmed	An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.	RIF1 PBRM1	5.48e-04	18	67	2	24025402
Pubmed	A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.	FREM2 LAMA2	5.48e-04	18	67	2	14730302
Pubmed	The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.	DTNBP1 STX1B	5.48e-04	18	67	2	19546860
Pubmed	The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse.	DTNBP1 AP3S2	5.48e-04	18	67	2	21998198
Pubmed	Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.	NUP188 HUWE1 KPNA1	6.03e-04	85	67	3	19596235
Pubmed	Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development.	EGR2 GRIN1	6.12e-04	19	67	2	28981898
Pubmed	Role of the Pbrm1 subunit and the PBAF complex in Schwann cell development.	PBRM1 EGR2	6.12e-04	19	67	2	35173232
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	ACAT1 SUPT6H RC3H1 HUWE1 DTNBP1	6.43e-04	358	67	5	32460013
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MYT1 HUWE1 MAPK8IP3	6.45e-04	87	67	3	12465718
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	RIF1 TOX4 PBRM1 NONO	6.48e-04	203	67	4	22083510
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	TTC28 SUPT6H NUP188 HUWE1 DTNBP1 USP1 COPS5 KPNA1	6.83e-04	1005	67	8	19615732
Pubmed	The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.	STX3 ACAT1 MDH1 NONO STX1B DDX1	6.84e-04	552	67	6	36293380
Pubmed	Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.	HUWE1 NONO DDX1 KPNA1	6.84e-04	206	67	4	22174317
Pubmed	Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.	CCDC47 NONO KPNA1	7.12e-04	90	67	3	33087562
Pubmed	Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.	EGR2 LAMA2	7.50e-04	21	67	2	28880149
Pubmed	RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2.	SYCP3 RYR2	7.50e-04	21	67	2	31712577
Pubmed	Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.	FREM2 HYDIN	7.50e-04	21	67	2	26234751
Pubmed	Schwann cell myelination requires integration of laminin activities.	EGR2 LAMA2	7.50e-04	21	67	2	22767514
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TTC28 SBNO1 GUCY1B1 ADGRB3 HUWE1 MDH1 COPS5 MAPK8IP3 KPNA1	7.77e-04	1285	67	9	35914814
Pubmed	Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.	TOX4 HUWE1 NONO DDX1 AP3S2	8.11e-04	377	67	5	25147182
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	CCDC47 MTR NUP188 HUWE1 COPS5 KPNA1	8.16e-04	571	67	6	37167062
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	LAMA2 GRIN1	8.24e-04	22	67	2	35245678
Pubmed	PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.	PBRM1 CCDC47 THOC2 DDX1	8.31e-04	217	67	4	31685992
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	FREM2 PBRM1 NONO DDX1	8.60e-04	219	67	4	31353912
Pubmed	Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis.	STX3 MDH1 USP1 COPS5	8.89e-04	221	67	4	31796584
GeneFamily	Syntaxins	STX3 STX1B	7.11e-04	16	45	2	818
Coexpression	BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP	TAOK2 TBXA2R PBRM1 LAMA2 AKAP13 THOC2 USP1 NONO IFNA5	6.37e-07	389	67	9	M6520
ToppCell	Healthy_donor-Platelet\|Healthy_donor / disease group, cell group and cell class (v2)	TBXA2R XIRP2 GUCY1B1 ODC1 RUFY1	9.21e-06	187	67	5	9040ffa5c23913b9dc0205fa6227223c2a2847ae
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|368C / Donor, Lineage, Cell class and subclass (all cells)	TOX4 ZNF713 NDUFAF5 AP4B1 ZAP70	9.45e-06	188	67	5	ecc2364d946f97ae0212fd6739960c9fc75e4919
ToppCell	PBMC-Mild-Hematopoietic\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R XIRP2 GUCY1B1 ODC1 RUFY1	9.45e-06	188	67	5	e3d9919eafc6181d2145b9d36f47066d0e22a8bd
ToppCell	PBMC-Mild-Hematopoietic\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TBXA2R XIRP2 GUCY1B1 ODC1 RUFY1	9.45e-06	188	67	5	6bd9317be8918da639254f4bdd432647c43ba9b1
ToppCell	mild_COVID-19-Platelet\|World / disease group, cell group and cell class (v2)	TBXA2R XIRP2 GUCY1B1 ODC1 RUFY1	9.70e-06	189	67	5	038ec3c266b89416bb5b774ba522d916394961da
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	XIRP2 LAMA2 AKAP13 RYR2 MAPK8IP3	9.95e-06	190	67	5	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	PBMC-Mild-Hematopoietic-Platelet\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R XIRP2 GUCY1B1 ODC1 RUFY1	9.95e-06	190	67	5	726aeb280ea911f3551b18e388c4f7580ae2ea74
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R XIRP2 GUCY1B1 ODC1 RUFY1	9.95e-06	190	67	5	50ea3ff7ba1ca335b4e4538fae5f9b74b1fc10f7
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TBXA2R XIRP2 GUCY1B1 ODC1 RUFY1	9.95e-06	190	67	5	a1f8757dc719ed030f67d65735358a8d7a407bad
ToppCell	PBMC-Mild-Hematopoietic-Platelet\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	TBXA2R XIRP2 GUCY1B1 ODC1 RUFY1	9.95e-06	190	67	5	c4f55f5a0c42aeb571791925ea80e02fac320608
ToppCell	mild_COVID-19_(asymptomatic)-Platelet\|World / disease group, cell group and cell class (v2)	TBXA2R XIRP2 GUCY1B1 ODC1 RUFY1	9.95e-06	190	67	5	7aaf82f0c235363afb95cf1fa51c2a5b070b1af8
ToppCell	mild_COVID-19-Platelet\|mild_COVID-19 / disease group, cell group and cell class (v2)	TBXA2R XIRP2 GUCY1B1 ODC1 RUFY1	1.02e-05	191	67	5	968e2d48969884dd21b8a87f199af94a7410b0dd
ToppCell	10x5'v1-week_14-16-Hematopoietic-MK-MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TBXA2R XIRP2 GUCY1B1 RUFY1 RYR2	1.05e-05	192	67	5	b877d14be9d04ab0010e340909e3a23de92613db
ToppCell	Substantia_nigra-Macroglia-CSF_related\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DNAH3 HKDC1 DNAI3 HYDIN	5.28e-05	136	67	4	47663c5d81c766a333207a44fc5b58b07309ee76
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DNAH3 HKDC1 DNAI3 HYDIN	5.28e-05	136	67	4	6d2e5b871f4cf8d64e6fe0be666fb3490797c635
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DNAH3 HKDC1 DNAI3 HYDIN	5.28e-05	136	67	4	fd4269d194c7c11c6ab4383393a01efab05cbace
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DNAH3 HKDC1 DNAI3 HYDIN	5.28e-05	136	67	4	3f6cec8d52c84191f7f6e2dd4dc47524dfd5b21b
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	DNAH3 HKDC1 DNAI3 HYDIN	5.28e-05	136	67	4	67d736096d6b6ddb4722809557f5e987063b8d23
ToppCell	367C-Epithelial_cells-Epithelial-A_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	HHIP RHOBTB2 HKDC1 AKAP13	1.09e-04	164	67	4	b0ed8cb6000ce8bf94444307e4b7b3574fa3fab2
ToppCell	367C-Epithelial_cells-Epithelial-A_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	HHIP RHOBTB2 HKDC1 AKAP13	1.09e-04	164	67	4	3aea6207a011ad55a1aeb2ed9fb54d31b23694b5
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HHIP HAP1 ODC1 ZAP70	1.14e-04	166	67	4	d1c61270c7b39bb365020eeafe298a8f88aa887e
ToppCell	Ciliated_cells-A-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	IQCD DNAI3 HYDIN IFNA5	1.25e-04	170	67	4	8b7ef1464ea589886b575ebad5447b085cbdcdba
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	GUCY1B1 HAP1 LAMA2 RYR2	1.28e-04	171	67	4	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	cellseq-Immune-Hematopoietic-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TBXA2R GUCY1B1 ODC1 RUFY1	1.31e-04	172	67	4	d0c3fb48c61762dcefca858cf13c9da8eb6d0f5e
ToppCell	cellseq-Immune-Hematopoietic-Megakaryocyte/Platelet\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TBXA2R GUCY1B1 ODC1 RUFY1	1.31e-04	172	67	4	eb2915165cab2660511e4b70c3a6d3ab2f770809
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HAP1 MYT1 ADGRB3 GRIN1	1.37e-04	174	67	4	742c73c9e090848b464323cb17579b86658c6792
ToppCell	E18.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	HAP1 MYT1 ADGRB3 GRIN1	1.37e-04	174	67	4	7fed9722e64c60843092f2ba71256e3043011ef6
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRB3 LAMA2 HYDIN RYR2	1.40e-04	175	67	4	887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HKDC1 IQCD DNAI3 HYDIN	1.46e-04	177	67	4	e8bb4f8ecd5e283efec966b9fc2040a6152d5551
ToppCell	(9)_Platelet\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	XIRP2 GUCY1B1 RUFY1 RYR2	1.46e-04	177	67	4	0830944c43de300815831a9e2b2fce40965e7d12
ToppCell	(9)_Platelet\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	XIRP2 GUCY1B1 RUFY1 RYR2	1.46e-04	177	67	4	e63d01c7fce4fa1256212fa7e95f74281edb3a01
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HKDC1 IQCD DNAI3 HYDIN	1.49e-04	178	67	4	b1db59344c074c7c80169fc2c5cd5fc89f3fe463
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TBXA2R XIRP2 GUCY1B1 RUFY1	1.49e-04	178	67	4	f5d83ad082e31d5601890d245b9fb4f9ef6a062b
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TBXA2R XIRP2 GUCY1B1 RUFY1	1.49e-04	178	67	4	a2a8fc14f492a4695e6991a357b6626145f1bf7f
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HKDC1 IQCD DNAI3 HYDIN	1.49e-04	178	67	4	579cdc14f28b459e200ae2102e0bd4df8a2c0dcb
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R XIRP2 GUCY1B1 RUFY1	1.53e-04	179	67	4	510927794bbd21814eba75286e0801eb1fd2e8a6
ToppCell	PBMC-Convalescent-Hematopoietic\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	TBXA2R XIRP2 GUCY1B1 RUFY1	1.53e-04	179	67	4	3b1616e974ea7792ff5c37da3b0281f28edfbb56
ToppCell	PBMC-Convalescent-Hematopoietic\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R XIRP2 GUCY1B1 RUFY1	1.53e-04	179	67	4	35271a4396a533f6d960ce55d171a32d9d2fd1a4
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R XIRP2 GUCY1B1 RUFY1	1.53e-04	179	67	4	906a5ebbbac660b6fd498ced09d0ada40a3e64af
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	XIRP2 DNAI3 ZAP70 RYR2	1.53e-04	179	67	4	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	COVID-19_Convalescent-Hematopoietic_Mega-Platelet\|COVID-19_Convalescent / Disease group, lineage and cell class	TBXA2R XIRP2 GUCY1B1 RUFY1	1.56e-04	180	67	4	deed53167504c91220b35a63366ed7d8f02a5254
ToppCell	COVID-19_Convalescent-Hematopoietic_Mega\|COVID-19_Convalescent / Disease group, lineage and cell class	TBXA2R XIRP2 GUCY1B1 RUFY1	1.56e-04	180	67	4	17323d382ae322e388e230fdad13e3464ea73e8e
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	DNAH3 IQCD DNAI3 HYDIN	1.59e-04	181	67	4	5a4574f1bfd0b4ca78da7effda43420857e17296
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)\|368C / Donor, Lineage, Cell class and subclass (all cells)	DNAH3 IQCD DNAI3 HYDIN	1.59e-04	181	67	4	a4e891603645f694687e68e585744ddc1a3c8697
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADGRB3 LAMA2 DNAI3 RYR2	1.59e-04	181	67	4	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NDUFAF5 HAP1 RHOBTB2 AP3S2	1.63e-04	182	67	4	c98da2db197b1531204e116600ff51891e5c17af
ToppCell	remission-Platelet\|remission / disease stage, cell group and cell class	TBXA2R XIRP2 GUCY1B1 RUFY1	1.63e-04	182	67	4	65e2798aacd670cbc3a8c8e9d1a2f7768513bb70
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAH3 IQCD DNAI3 HYDIN	1.63e-04	182	67	4	975f6275777fc578eba528e50f69891c66ec44ad
ToppCell	368C-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAH3 IQCD DNAI3 HYDIN	1.63e-04	182	67	4	f8c28fa76751062c4cfba0db8af1b377f947f739
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 XIRP2 HYDIN RYR2	1.70e-04	184	67	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	10x3'2.3-week_17-19-Hematopoietic-MK-MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	XIRP2 GUCY1B1 RUFY1 RYR2	1.70e-04	184	67	4	ba65e3972b2b8d825a2c1a9d03d092cc1afad073
ToppCell	control-Others\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	TBXA2R GUCY1B1 ODC1 RUFY1	1.70e-04	184	67	4	a63b39fcc570b554cf10e8e47c2c1e079034768f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 XIRP2 HYDIN RYR2	1.70e-04	184	67	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 XIRP2 HYDIN RYR2	1.70e-04	184	67	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	XIRP2 LAMA2 AKAP13 RYR2	1.70e-04	184	67	4	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	control-Others-Megakaryocytes\|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	TBXA2R GUCY1B1 ODC1 RUFY1	1.70e-04	184	67	4	213915f2889ce8ecbe5f7b19bc2b24ed8c5efe1d
ToppCell	megakaryocytic\|World / Lineage and Cell class	TBXA2R GUCY1B1 RUFY1 RYR2	1.70e-04	184	67	4	b1c630ca2189d9d49402a5621b57618976fbea5c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	XIRP2 GUCY1B1 RUFY1 RYR2	1.73e-04	185	67	4	9bff336510c80cd762b4e41b4570475033e709ca
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic-Megakaryocyte-Mega\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	XIRP2 GUCY1B1 RUFY1 RYR2	1.73e-04	185	67	4	452d49c7835a4d55e41caefa44dac5cab30e7ced
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic-Megakaryocyte\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	XIRP2 GUCY1B1 RUFY1 RYR2	1.73e-04	185	67	4	53f5136ee1bd101dd5ac8a2c9e63b0c3b987657e
ToppCell	PBMC-Control-Hematopoietic\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R GUCY1B1 ODC1 RUFY1	1.73e-04	185	67	4	c95c77d4302d7fff7fdef1774f15a93ba9ced61a
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TBXA2R GUCY1B1 ODC1 RUFY1	1.73e-04	185	67	4	0a2c8ce92a257d0ec5bcc8efa22792d53752c665
ToppCell	PBMC-Control-Hematopoietic\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TBXA2R GUCY1B1 ODC1 RUFY1	1.73e-04	185	67	4	72a281ef246de5b30de1241d792c25bfae60e797
ToppCell	PBMC-Severe-Hematopoietic-Platelet-Platelet-plt_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TBXA2R XIRP2 GUCY1B1 RUFY1	1.73e-04	185	67	4	698ff44fd2d9b3ad5cea45f4cff9bfc64c559b62
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Hematopoietic-Megakaryocytic\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	XIRP2 GUCY1B1 RUFY1 RYR2	1.73e-04	185	67	4	67ac5c2bacdbdcb40ee65c44da55b3f597b410ee
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TBXA2R GUCY1B1 ODC1 RUFY1	1.77e-04	186	67	4	3bf38c80d892a73391009b426dec8ae26a027351
ToppCell	PBMC-Control-Hematopoietic-Platelet\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	TBXA2R GUCY1B1 ODC1 RUFY1	1.77e-04	186	67	4	7496137cebc191aecd1e6ae7fa33118b128fbfe6
ToppCell	Megakaryocytic-erythropoietic-Megakaryo-cells-Platelet\|World / Lineage, cell class and subclass	TBXA2R GUCY1B1 ODC1 RUFY1	1.77e-04	186	67	4	27807334e7241c8a9aeaf6403f0fd0b001fbc0d1
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R GUCY1B1 ODC1 RUFY1	1.77e-04	186	67	4	4a9b5b3a56229629161d5404db2b8dd76e10cf4b
ToppCell	PBMC-Control-Hematopoietic-Platelet\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R GUCY1B1 ODC1 RUFY1	1.77e-04	186	67	4	9c2fd0bbc968c317a763f52e72fa7182c3c49850
ToppCell	megakaryocytic-Megakaryocyte\|World / Lineage and Cell class	TBXA2R GUCY1B1 RUFY1 RYR2	1.77e-04	186	67	4	acd15a169b6122b28cc99ef34de10701edcfedfe
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R GUCY1B1 ODC1 RUFY1	1.77e-04	186	67	4	06281df5e9665ccc510279bf7e552845c63d5dab
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	NDUFAF5 HAP1 USP1 AP3S2	1.77e-04	186	67	4	bbb8edea8d8bdc1a469faec1563e40b1f62d7f3d
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	HHIP GUCY1B1 SUPT6H LAMA2	1.77e-04	186	67	4	e044b3428b7eacfdc72d0f57cdabaa1de04c74cd
ToppCell	PBMC-Severe-Hematopoietic-Platelet-Platelet-plt_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R XIRP2 GUCY1B1 RUFY1	1.77e-04	186	67	4	981116561986f94e9cc3ee64fb37dab9a31d427a
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FREM2 HHIP RHOBTB2 AKAP13	1.81e-04	187	67	4	5df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell	Control-Hematopoietic_Mega-Platelet\|Control / Disease group, lineage and cell class	TBXA2R GUCY1B1 ODC1 RUFY1	1.81e-04	187	67	4	53e9665e1feb02ce8fe78ff4128fd4beacef8471
ToppCell	severe-Platelet\|World / disease stage, cell group and cell class	TBXA2R XIRP2 GUCY1B1 RUFY1	1.81e-04	187	67	4	72475fb6d053354b581e61c6eee3719a7dd08c8b
ToppCell	Control-Hematopoietic_Mega\|Control / Disease group, lineage and cell class	TBXA2R GUCY1B1 ODC1 RUFY1	1.81e-04	187	67	4	7bf98bdc83feb3918dbcf12e87a64fe4d2d41eba
ToppCell	Ciliated_cells-B-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	DNAH3 IQCD DNAI3 HYDIN	1.81e-04	187	67	4	bc1f33f332ac939c2425f510173430ca2ba0c3ee
ToppCell	remission-Platelet\|World / disease stage, cell group and cell class	TBXA2R XIRP2 GUCY1B1 RUFY1	1.84e-04	188	67	4	fa69f20ef6b8ce620ba342f0984d40ddf259bc3f
ToppCell	Healthy/Control-Platelet\|World / Disease group and Cell class	TBXA2R GUCY1B1 ODC1 RUFY1	1.84e-04	188	67	4	552077e4597d0956f4d8c40c9de8f109e87cb857
ToppCell	Ciliated_cells-B-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	DNAH3 IQCD DNAI3 HYDIN	1.84e-04	188	67	4	606907c865bd2f11bb6474932716550f7723d858
ToppCell	severe_influenza-Platelet\|World / disease group, cell group and cell class (v2)	TBXA2R XIRP2 GUCY1B1 RUFY1	1.84e-04	188	67	4	b54632baa682aaf51100d44e7f114a54d5edd695
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D231\|Adult / Lineage, Cell type, age group and donor	FREM2 HHIP DOCK9 RHOBTB2	1.88e-04	189	67	4	dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	XIRP2 LAMA2 AKAP13 RYR2	1.88e-04	189	67	4	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	Multiciliated\|World / shred by cell class for nasal brushing	DNAH3 IQCD DNAI3 HYDIN	1.88e-04	189	67	4	34b110aef839376228c5a403a6b5047a945f472b
ToppCell	Mesenchymal-pericyte_cell\|World / Lineage, Cell type, age group and donor	GUCY1B1 HAP1 LAMA2 RYR2	1.88e-04	189	67	4	d7ed96add29f219183c802895fbff519b627f635
ToppCell	Healthy-Platelet\|Healthy / disease group, cell group and cell class	TBXA2R GUCY1B1 ODC1 RUFY1	1.88e-04	189	67	4	5863e132536594e49bffbb637454cc43dfdbaa20
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	XIRP2 AKAP13 RYR2 MAPK8IP3	1.88e-04	189	67	4	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R GUCY1B1 ODC1 RUFY1	1.92e-04	190	67	4	b719061be370ffc293854f1f6e526bf33cd2f442
ToppCell	COVID-19_Moderate-Platelet\|World / disease group, cell group and cell class	TBXA2R GUCY1B1 ODC1 RUFY1	1.92e-04	190	67	4	6e4f4af5ba185bb022753881a26a269a544bb59b
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TBXA2R GUCY1B1 ODC1 RUFY1	1.92e-04	190	67	4	427038bae9c7b3a9441c8d59ace69da74e9d37bf
ToppCell	COVID-19_Moderate-Platelet\|COVID-19_Moderate / disease group, cell group and cell class	TBXA2R GUCY1B1 ODC1 RUFY1	1.92e-04	190	67	4	3bf4ab3fd3a391da98a83e2aac0881a0e5c8f8b0
ToppCell	severe-Platelet\|severe / disease stage, cell group and cell class	TBXA2R XIRP2 GUCY1B1 RUFY1	1.92e-04	190	67	4	497ec3fe4dd6f1b4fa6e76d9ac07df497efce7a2
ToppCell	PBMC-Severe-Hematopoietic-Platelet-Platelet-plt_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TBXA2R GUCY1B1 ODC1 RUFY1	1.96e-04	191	67	4	7da172553ed6df4a0c34ecd55665a9598b5071a5
ToppCell	PBMC-Severe-Hematopoietic-Platelet-Platelet-plt_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TBXA2R GUCY1B1 ODC1 RUFY1	1.96e-04	191	67	4	1a1bf85bc77bf093a0ac2cb9eabaeac820a7b93e
ToppCell	COVID-19_Mild-Hematopoietic_Mega-Platelet\|COVID-19_Mild / Disease group, lineage and cell class	TBXA2R GUCY1B1 ODC1 RUFY1	1.96e-04	191	67	4	6b3cfc670f69ed3e757cbf7498943e549e31326e
ToppCell	ASK428-Epithelial-Ciliated\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	DNAH3 IQCD DNAI3 HYDIN	1.96e-04	191	67	4	0c4b926a28bc94f3cf4d68a911c0a189f6ff505e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STX3 TTC28 HKDC1 HYDIN	1.96e-04	191	67	4	1cb02007adb344f17ef73d58890f91298c7cf5a1
Drug	dexamethasone; Up 200; 1uM; MCF7; HG-U133A	TAOK2 DNAH3 HAP1 RNF41 GRIN1 SBNO2 MAPK8IP3	1.83e-06	197	67	7	255_UP
Drug	CP-690334-01 [459212-38-5]; Up 200; 10uM; PC3; HT_HG-U133A	ADGRB3 AKAP13 GRIN1 NUP188 RYR2 MAPK8IP3	1.92e-05	188	67	6	3823_UP
Drug	Simvastatin [79902-63-9]; Up 200; 9.6uM; PC3; HT_HG-U133A	S100P HAP1 DOCK9 ADGRB3 LAMA2 AKAP13	2.16e-05	192	67	6	4244_UP
Drug	Cimetidine [51481-61-9]; Up 200; 15.8uM; PC3; HT_HG-U133A	TAOK2 TBXA2R RIF1 ADGRB3 LAMA2 MAPK8IP3	2.36e-05	195	67	6	4063_UP
Drug	chlorpromazine hydrochloride; Up 200; 1uM; MCF7; HT_HG-U133A	TAOK2 HAP1 DOCK9 NUP188 HUWE1 RYR2	2.43e-05	196	67	6	5577_UP
Drug	Mephenytoin [50-12-4]; Up 200; 18.4uM; HL60; HT_HG-U133A	GUCY1B1 HAP1 DOCK9 MYT1 GRIN1 HUWE1	2.43e-05	196	67	6	6158_UP
Drug	indomethacin, USP; Down 200; 20uM; MCF7; HG-U133A	TBXA2R DOCK9 LAMA2 GRIN1 IFNA5 SBNO2	2.43e-05	196	67	6	262_DN
Drug	dansylputrescine	TGM1 ODC1	2.55e-05	3	67	2	CID000598792
Drug	Ebselen [60940-34-3]; Up 200; 14.6uM; PC3; HT_HG-U133A	RIF1 LAMA2 AKAP13 RYR2 SBNO2 MAPK8IP3	2.57e-05	198	67	6	5778_UP
Drug	Tolnaftate [2398-96-1]; Down 200; 13uM; MCF7; HT_HG-U133A	TTC28 HAP1 SUPT6H AKAP13 SBNO2 ZNF710	2.57e-05	198	67	6	4805_DN
Drug	2-methyl-3-hydroxybutyryl-CoA	ACADVL ACAT1 HUWE1	4.14e-05	23	67	3	CID000000052
Drug	Hydroxocobalamin	GUCY1B1 MTR	5.10e-05	4	67	2	ctd:D006879
Drug	cyclopentene oxide	TBXA2R AGA	5.10e-05	4	67	2	CID000009244
Disease	Schizophrenia	PBRM1 SBNO1 EGR2 AGA MTR LAMA2 MDH1 DTNBP1 SBNO2 KPNA1	2.21e-05	883	65	10	C0036341
Disease	Bipolar Disorder	PBRM1 EGR2 DOCK9 MTR RNF41 GRIN1 DTNBP1	8.56e-05	477	65	7	C0005586
Disease	squamous cell carcinoma, esophageal carcinoma	HAP1 HEATR3	2.13e-04	10	65	2	EFO_0000707, EFO_0002916
Disease	Global developmental delay	CCDC47 RHOBTB2 ODC1 MAPK8IP3	2.16e-04	133	65	4	C0557874
Disease	Intellectual Disability	ZNF526 CCDC47 RHOBTB2 GRIN1 ODC1 MAPK8IP3	4.54e-04	447	65	6	C3714756
Disease	schizophrenia (implicated_via_orthology)	SBNO1 GRIN1 DTNBP1	4.62e-04	68	65	3	DOID:5419 (implicated_via_orthology)
Disease	breast milk measurement	STX3 AGA ZAP70	1.67e-03	106	65	3	EFO_0009092

Protein segments in the cluster

Peptide	Gene	Start	Entry
EVMGLMLGKVDGETM	COPS5	76	Q92905
MLGKVDGETMIIMDS	COPS5	81	Q92905
QVIEDFIHIVGMGMM	ADGRB3	676	O60242
REDMEGMLGEDVMRA	IQCD	76	Q96DY2
ISMGMTDPEMVEVHA	AKAP13	2301	Q12802
QEVVMGGMVLETNMN	AP3S2	121	P59780
TQGLDMSGVFMEMVK	AP4B1	41	Q9Y6B7
AASEDMEPVNMESMG	DNAI3	21	Q8IWG1
DLMSDAMEEIDMQQG	ATG2B	1411	Q96BY7
GSVEMMNVESKGMRD	RC3H1	836	Q5TC82
MNGVAGDGMINIDMT	EGR2	51	P11161
AGEEGMIEDMKLMFR	PBRM1	581	Q86U86
DAREQEIRMGQMAMG	NONO	376	Q15233
MMEIQMDEGGGVVVY	MAPK8IP3	1	Q9UPT6
REFMVMEGMSLVIDT	FREM2	1196	Q5SZK8
ILSEMGEVTDGMMDT	CCDC47	301	Q96A33
EMGVMPEIAQAVEEM	DDX1	6	Q92499
MMGVLDGVLMELQDC	MDH1	46	P40925
GSMSSMEVNVDMLEQ	DTNBP1	226	Q96EV8
ACMMQEVGVEDTPLM	IFNA5	121	P01569
SSQKMDGMGIEMIDE	LAMA2	2981	P24043
DGMGIEMIDEKLMFH	LAMA2	2986	P24043
LDMMEIAGQVQVDGE	GUCY1B1	501	Q02153
EEDQMMRAIAMSLGQ	HUWE1	1371	Q7Z6Z7
VLGMDMGLREMCVGE	FKBP9	426	O95302
SEVLGMDAGEMVIQM	HEATR3	281	Q7Z4Q2
LEESMGAVQMGLVNM	HYDIN	6	Q4G0P3
NIDEEASMMEDVGMQ	DOCK9	1691	Q9BZ29
EQMMLASMREVIGLG	DNAH3	1251	Q8TD57
MDCGGMLIEMQEEVK	HAP1	441	P54257
TLDAMIMDGTTMDVG	AGA	86	P20933
MGDDMVQEPGLVMIF	RNF41	296	Q9H4P4
ERRGVGAMEIVAMDM	SBNO1	511	A3KN83
GMHETVMEVMVNVLG	RYR2	2166	Q92736
NGVQMMTFDSEVELM	ODC1	126	P11926
GVVEDMGGEVQNMLE	SYCP3	61	Q8IZU3
MEDMRNIEMVEGGEG	HKDC1	686	Q2TB90
NEEMMIGEAMAETGH	RIF1	2021	Q5UIP0
EMAPGGVITSDMIEM	KPNA1	76	P52294
MPVSEMAEDGSEEIM	PRDM15	296	P57071
EALMMEEEGMVIVGL	RUFY1	241	Q96T51
MVLDGGMGTMIQREK	MTR	31	Q99707
TGLMEATQMMVDIDG	RHOBTB2	596	Q9BYZ6
EEGPEAREMAMMQEG	TAOK2	391	Q9UL54
EKRGVGAMEIVAMDM	SBNO2	456	Q9Y2G9
DVMVAGGMESMSNVP	ACAT1	146	P24752
MFELMEDLQGMGESN	NDUFAF5	251	Q5TEU4
DGMITLDDMEEMDGL	HHIP	371	Q96QV1
MDIAMLVENQGEMLD	STX3	216	Q13277
DECIQIMGGMGFMKE	ACADVL	431	P49748
MMETMDQGDVIIRPS	SUPT6H	1346	Q7KZ85
NMMEESEMCAVPGGL	XIRP2	66	A4UGR9
QAEALMLVMEMAGGG	ZAP70	406	P43403
MAGIEITEEMTMEQL	THOC2	686	Q8NI27
ITEEMTMEQLEAMTG	THOC2	691	Q8NI27
VDMAMLVESQGEMID	STX1B	216	P61266
MDIGLDSQDPMMELT	ZNF710	601	Q8N1W2
MGIGVDTIDMVMAAQ	NUP188	781	Q5SRE5
MTELETAMGMIIDVF	S100P	1	P25815
EDGALMDGGMDLNME	TMEM208	81	Q9BTX3
GITKMNMNVMEEAIG	TTC28	841	Q96AY4
MAEVVAEVAEMPTQM	ZNF526	1	Q8TF50
MEMSTEVTEMTPGEA	ZNF526	31	Q8TF50
QDAVMGQDLMVSVML	TGM1	586	P22735
EGNMEEEEMNDGSQM	ZNF713	11	Q8N859
VEMMAQLLGIMVVAS	TBXA2R	241	P21731
TLDMPVGMTHGLMEQ	TOX4	81	O94842
MNMEGLVMFQDLSID	ZNF850	1	A8MQ14
EEMNGINSIEMDSMR	USP1	241	O94782
ESEMQDMMTRGNLGL	MYT1	366	Q01538
MMGELLSGQADMIVA	GRIN1	501	Q05586