Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium-independent organic anion transmembrane transporter activity	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	7.36e-08	18	46	4	GO:0015347
GeneOntologyMolecularFunction	prostaglandin transmembrane transporter activity	SLCO2B1 SLCO2A1 SLCO3A1	4.09e-06	14	46	3	GO:0015132
GeneOntologyMolecularFunction	icosanoid transmembrane transporter activity	SLCO2B1 SLCO2A1 SLCO3A1	5.11e-06	15	46	3	GO:0071714
GeneOntologyMolecularFunction	DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates	DNMT3A DNMT3B	5.19e-06	2	46	2	GO:0051719
GeneOntologyMolecularFunction	DNA (cytosine-5-)-methyltransferase activity	DNMT3A DNMT3B	3.11e-05	4	46	2	GO:0003886
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLCO4C1 SLC25A40 SLCO2B1 SLC25A39 SLCO2A1 SLCO3A1	5.42e-05	293	46	6	GO:0008514
GeneOntologyMolecularFunction	DNA-methyltransferase activity	DNMT3A DNMT3B	1.08e-04	7	46	2	GO:0009008
GeneOntologyMolecularFunction	glutathione transmembrane transporter activity	SLC25A40 SLC25A39	1.08e-04	7	46	2	GO:0034634
GeneOntologyMolecularFunction	tripeptide transmembrane transporter activity	SLC25A40 SLC25A39	1.85e-04	9	46	2	GO:0042937
GeneOntologyMolecularFunction	oligopeptide transmembrane transporter activity	SLC25A40 SLC25A39	6.10e-04	16	46	2	GO:0035673
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	SLCO2B1 SLCO2A1 SLCO3A1	6.36e-04	73	46	3	GO:0170055
GeneOntologyMolecularFunction	calcium-dependent cysteine-type endopeptidase activity	CAPN13 CAPN5	6.91e-04	17	46	2	GO:0004198
GeneOntologyMolecularFunction	cysteine-type endopeptidase activity	CAPN13 CAPN5 CTSZ	1.02e-03	86	46	3	GO:0004197
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	SLC25A40 SLC25A39	2.62e-03	33	46	2	GO:0072349
GeneOntologyMolecularFunction	lncRNA binding	DNMT3A DNMT3B	2.94e-03	35	46	2	GO:0106222
GeneOntologyMolecularFunction	endopeptidase activity	CAPN13 ADAMTS10 PRSS21 CAPN5 CTSZ	3.00e-03	430	46	5	GO:0004175
GeneOntologyMolecularFunction	amide transmembrane transporter activity	SLC25A40 SLC25A39	4.22e-03	42	46	2	GO:0042887
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	4.73e-03	296	46	4	GO:0015291
GeneOntologyBiologicalProcess	sodium-independent organic anion transport	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	2.90e-08	15	46	4	GO:0043252
GeneOntologyBiologicalProcess	icosanoid transport	AVPR1B SLCO2B1 SLCO2A1 SLCO3A1	2.11e-05	73	46	4	GO:0071715
GeneOntologyBiologicalProcess	prostaglandin transport	SLCO2B1 SLCO2A1 SLCO3A1	5.92e-05	34	46	3	GO:0015732
GeneOntologyBiologicalProcess	organic anion transport	SLCO4C1 SLC25A40 AVPR1B SLCO2B1 SLC25A39 SLCO2A1 SLCO3A1	1.34e-04	515	46	7	GO:0015711
GeneOntologyBiologicalProcess	glutathione transmembrane transport	SLC25A40 SLC25A39	1.35e-04	8	46	2	GO:0034775
GeneOntologyBiologicalProcess	autosome genomic imprinting	DNMT3A DNMT3B	1.73e-04	9	46	2	GO:0141068
GeneOntologyBiologicalProcess	fatty acid transport	AVPR1B SLCO2B1 SLCO2A1 SLCO3A1	2.12e-04	132	46	4	GO:0015908
GeneOntologyBiologicalProcess	tripeptide transmembrane transport	SLC25A40 SLC25A39	2.16e-04	10	46	2	GO:0035443
GeneOntologyBiologicalProcess	glutathione transport	SLC25A40 SLC25A39	2.64e-04	11	46	2	GO:0034635
GeneOntologyBiologicalProcess	tripeptide transport	SLC25A40 SLC25A39	3.74e-04	13	46	2	GO:0042939
Domain	OA_transporter	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	1.57e-08	12	46	4	IPR004156
Domain	OATP	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	1.57e-08	12	46	4	PF03137
Domain	KAZAL_2	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	6.83e-06	50	46	4	PS51465
Domain	Kazal_dom	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	7.39e-06	51	46	4	IPR002350
Domain	THIOL_PROTEASE_CYS	CAPN13 CAPN5 CTSZ	3.49e-05	26	46	3	PS00139
Domain	ADD	DNMT3A DNMT3B	3.55e-05	4	46	2	IPR025766
Domain	C5_MTASE_1	DNMT3A DNMT3B	3.55e-05	4	46	2	PS00094
Domain	C5_MTASE_2	DNMT3A DNMT3B	3.55e-05	4	46	2	PS00095
Domain	ADD	DNMT3A DNMT3B	3.55e-05	4	46	2	PS51533
Domain	SAM_MT_C5	DNMT3A DNMT3B	3.55e-05	4	46	2	PS51679
Domain	DNA_methylase	DNMT3A DNMT3B	3.55e-05	4	46	2	PF00145
Domain	C5_MeTfrase	DNMT3A DNMT3B	3.55e-05	4	46	2	IPR001525
Domain	C5_DNA_meth_AS	DNMT3A DNMT3B	3.55e-05	4	46	2	IPR018117
Domain	THIOL_PROTEASE_ASN	CAPN13 CAPN5 CTSZ	3.92e-05	27	46	3	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN13 CAPN5 CTSZ	3.92e-05	27	46	3	PS00639
Domain	Kazal_2	SLCO4C1 SLCO2A1 SLCO3A1	9.43e-05	36	46	3	PF07648
Domain	MFS_dom	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	3.27e-04	134	46	4	IPR020846
Domain	Calpain_domain_III	CAPN13 CAPN5	4.55e-04	13	46	2	IPR022682
Domain	Calpain_III	CAPN13 CAPN5	4.55e-04	13	46	2	PF01067
Domain	Calpain_cysteine_protease	CAPN13 CAPN5	5.30e-04	14	46	2	IPR022684
Domain	CysPc	CAPN13 CAPN5	6.11e-04	15	46	2	SM00230
Domain	CALPAIN_CAT	CAPN13 CAPN5	6.11e-04	15	46	2	PS50203
Domain	Peptidase_C2_calpain_cat	CAPN13 CAPN5	6.11e-04	15	46	2	IPR001300
Domain	Peptidase_C2	CAPN13 CAPN5	6.11e-04	15	46	2	PF00648
Domain	PWWP	DNMT3A DNMT3B	1.10e-03	20	46	2	SM00293
Domain	PWWP	DNMT3A DNMT3B	1.45e-03	23	46	2	PF00855
Domain	PWWP_dom	DNMT3A DNMT3B	1.45e-03	23	46	2	IPR000313
Domain	PWWP	DNMT3A DNMT3B	1.58e-03	24	46	2	PS50812
Domain	Pept_cys_AS	CAPN5 CTSZ	2.15e-03	28	46	2	IPR000169
Domain	Alkaline_phosphatase_core	ARSB PIGO	2.64e-03	31	46	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ARSB PIGO	2.64e-03	31	46	2	IPR017849
Domain	-	ARSB PIGO	2.64e-03	31	46	2	3.40.720.10
Domain	Znf_FYVE_PHD	ING1 DNMT3A DNMT3B	5.66e-03	147	46	3	IPR011011
Domain	KAZAL	SLCO2A1 SLCO3A1	5.73e-03	46	46	2	SM00280
Domain	DnaJ	DNAJC25 DNAJC22	6.23e-03	48	46	2	PF00226
Domain	DnaJ	DNAJC25 DNAJC22	6.48e-03	49	46	2	SM00271
Domain	DNAJ_1	DNAJC25 DNAJC22	6.48e-03	49	46	2	PS00636
Domain	DNAJ_2	DNAJC25 DNAJC22	6.48e-03	49	46	2	PS50076
Domain	-	DNAJC25 DNAJC22	6.48e-03	49	46	2	1.10.287.110
Domain	DnaJ_domain	DNAJC25 DNAJC22	7.01e-03	51	46	2	IPR001623
Domain	SOLCAR	SLC25A40 SLC25A39	7.55e-03	53	46	2	PS50920
Domain	Mito_carr	SLC25A40 SLC25A39	7.55e-03	53	46	2	PF00153
Domain	-	SLC25A40 SLC25A39	7.55e-03	53	46	2	1.50.40.10
Domain	Mt_carrier_dom	SLC25A40 SLC25A39	7.55e-03	53	46	2	IPR023395
Domain	Mitochondrial_sb/sol_carrier	SLC25A40 SLC25A39	7.55e-03	53	46	2	IPR018108
Pathway	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	1.31e-08	11	37	4	M930
Pathway	REACTOME_TRANSPORT_OF_ORGANIC_ANIONS	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	1.96e-08	12	37	4	MM15476
Pathway	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	3.79e-06	41	37	4	MM15075
Pathway	REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	4.61e-06	43	37	4	M881
Pathway	KEGG_MEDICUS_REFERENCE_METHIONINE_DEGRADATION	DNMT3A DNMT3B	2.98e-04	10	37	2	M47939
Pathway	WP_SPINA_BIFIDA	DNMT3A DNMT3B	4.35e-04	12	37	2	M48321
Pathway	WP_SULFATASE_AND_AROMATASE_PATHWAY	SLCO4C1 SLCO2B1	5.98e-04	14	37	2	M48085
Pathway	REACTOME_SUMOYLATION_OF_DNA_METHYLATION_PROTEINS	DNMT3A DNMT3B	7.86e-04	16	37	2	M27403
Pathway	WP_ETHER_LIPID_BIOSYNTHESIS	LPIN1 PEX16	1.24e-03	20	37	2	M46451
Pathway	WP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX	DNMT3A DNMT3B	1.36e-03	21	37	2	M39593
Pubmed	Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties.	SLCO4C1 SLCO2B1 SLCO2A1 SLCO3A1	1.24e-09	11	50	4	14579113
Pubmed	B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation.	CD19 DNMT3A DNMT3B	2.80e-09	3	50	3	29765016
Pubmed	Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.	SLCO4C1 SLCO2B1 SLCO3A1	1.56e-07	8	50	3	19129463
Pubmed	Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.	SLCO2B1 SLCO2A1 SLCO3A1	1.55e-06	16	50	3	35307651
Pubmed	Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b.	DNMT3A DNMT3B	2.03e-06	2	50	2	12869530
Pubmed	Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase.	DNMT3A DNMT3B	2.03e-06	2	50	2	26098813
Pubmed	The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin.	DNMT3A DNMT3B	2.03e-06	2	50	2	15456878
Pubmed	A single amino acid substitution confers enhanced methylation activity of mammalian Dnmt3b on chromatin DNA.	DNMT3A DNMT3B	2.03e-06	2	50	2	20507910
Pubmed	Analysis of DNA methylation change induced by Dnmt3b in mouse hepatocytes.	DNMT3A DNMT3B	2.03e-06	2	50	2	23611774
Pubmed	Epigenetic inheritance is unfaithful at intermediately methylated CpG sites.	DNMT3A DNMT3B	2.03e-06	2	50	2	37660134
Pubmed	The human DNA methyltransferases DNMT3A and DNMT3B have two types of promoters with different CpG contents.	DNMT3A DNMT3B	2.03e-06	2	50	2	12359337
Pubmed	Liver-specific deletion of de novo DNA methyltransferases protects against glucose intolerance in high-fat diet-fed male mice.	DNMT3A DNMT3B	2.03e-06	2	50	2	38795327
Pubmed	Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-beta2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A.	DNMT3A DNMT3B	2.03e-06	2	50	2	20426865
Pubmed	Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development.	DNMT3A DNMT3B	2.03e-06	2	50	2	32581223
Pubmed	Chromatin targeting of de novo DNA methyltransferases by the PWWP domain.	DNMT3A DNMT3B	2.03e-06	2	50	2	14998998
Pubmed	An investigation of genetic variability of DNA methyltransferases DNMT3A and 3B does not provide evidence for a major role in the pathogenesis of panic disorder and dimensional anxiety phenotypes.	DNMT3A DNMT3B	2.03e-06	2	50	2	32468273
Pubmed	High expression of DNMT3A and DNMT3B regulatory factors of TGFB in non-neoplastic liver tissues of HCC.	DNMT3A DNMT3B	2.03e-06	2	50	2	37807334
Pubmed	Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA.	DNMT3A DNMT3B	2.03e-06	2	50	2	19620278
Pubmed	Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells.	CD19 DNMT3A	2.03e-06	2	50	2	29326230
Pubmed	Activation of Notch and Myc Signaling via B-cell-Restricted Depletion of Dnmt3a Generates a Consistent Murine Model of Chronic Lymphocytic Leukemia.	CD19 DNMT3A	2.03e-06	2	50	2	34686499
Pubmed	Association of DNA methyltransferases 3A and 3B polymorphisms, and plasma folate levels with the risk of urothelial carcinoma.	DNMT3A DNMT3B	2.03e-06	2	50	2	25126948
Pubmed	Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization.	DNMT3A DNMT3B	2.03e-06	2	50	2	15757890
Pubmed	Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.	DNMT3A DNMT3B	2.03e-06	2	50	2	33846253
Pubmed	De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state.	DNMT3A DNMT3B	2.03e-06	2	50	2	21576263
Pubmed	DNA methylation and demethylation in mammals.	DNMT3A DNMT3B	2.03e-06	2	50	2	21454628
Pubmed	Profound flanking sequence preference of Dnmt3a and Dnmt3b mammalian DNA methyltransferases shape the human epigenome.	DNMT3A DNMT3B	2.03e-06	2	50	2	15854647
Pubmed	Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse.	DNMT3A DNMT3B	2.03e-06	2	50	2	16725135
Pubmed	Ontogeny of CpG island methylation and specificity of DNMT3 methyltransferases during embryonic development in the mouse.	DNMT3A DNMT3B	2.03e-06	2	50	2	25476147
Pubmed	DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro.	DNMT3A DNMT3B	2.03e-06	2	50	2	27468168
Pubmed	Nucleosomes containing methylated DNA stabilize DNA methyltransferases 3A/3B and ensure faithful epigenetic inheritance.	DNMT3A DNMT3B	2.03e-06	2	50	2	21304883
Pubmed	Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B.	DNMT3A DNMT3B	2.03e-06	2	50	2	26993463
Pubmed	DNA methylation density influences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation.	DNMT3A DNMT3B	2.03e-06	2	50	2	12370304
Pubmed	MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.	DNMT3A DNMT3B	2.03e-06	2	50	2	17890317
Pubmed	Cloning, expression and chromosome locations of the human DNMT3 gene family.	DNMT3A DNMT3B	2.03e-06	2	50	2	10433969
Pubmed	Dissect the DNMT3A- and DNMT3B-mediated DNA Co-methylation through a Covalent Complex Approach.	DNMT3A DNMT3B	2.03e-06	2	50	2	31726062
Pubmed	DNA methyltransferase-3-dependent nonrandom template segregation in differentiating embryonic stem cells.	DNMT3A DNMT3B	2.03e-06	2	50	2	24127215
Pubmed	DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction.	DNMT3A DNMT3B	2.03e-06	2	50	2	17485486
Pubmed	DNMT3A and DNMT3B Targeting as an Effective Radiosensitizing Strategy in Embryonal Rhabdomyosarcoma.	DNMT3A DNMT3B	2.03e-06	2	50	2	34831178
Pubmed	Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B.	DNMT3A DNMT3B	2.03e-06	2	50	2	32968275
Pubmed	DNMT3A/3B overexpression might be correlated with poor patient survival, hypermethylation and low expression of ESR1/PGR in endometrioid carcinoma: an analysis of The Cancer Genome Atlas.	DNMT3A DNMT3B	2.03e-06	2	50	2	30614867
Pubmed	Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain.	DNMT3A DNMT3B	2.03e-06	2	50	2	30258352
Pubmed	Expression and potential role of microRNA-29b in mouse early embryo development.	DNMT3A DNMT3B	2.03e-06	2	50	2	25766529
Pubmed	Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.	DNMT3A DNMT3B	2.03e-06	2	50	2	12897133
Pubmed	Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases.	DNMT3A DNMT3B	2.03e-06	2	50	2	9662389
Pubmed	Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation.	DNMT3A DNMT3B	2.03e-06	2	50	2	17579209
Pubmed	Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3.	SLCO2B1 SLCO2A1	2.03e-06	2	50	2	26692285
Pubmed	Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells.	DNMT3A DNMT3B	2.03e-06	2	50	2	25130491
Pubmed	The influence of DNMT3A and DNMT3B gene polymorphisms on acute myeloid leukemia risk in a Moroccan population.	DNMT3A DNMT3B	2.03e-06	2	50	2	32912818
Pubmed	Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.	DNMT3A DNMT3B	2.03e-06	2	50	2	16501171
Pubmed	Risk of Developing Hepatocellular Carcinoma following Depressive Disorder Based on the Expression Level of Oatp2a1 and Oatp2b1.	SLCO2B1 SLCO2A1	2.03e-06	2	50	2	31467884
Pubmed	Assignment of cytosine-5 DNA methyltransferases Dnmt3a and Dnmt3b to mouse chromosome bands 12A2-A3 and 2H1 by in situ hybridization.	DNMT3A DNMT3B	2.03e-06	2	50	2	10575238
Pubmed	Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.	DNMT3A DNMT3B	2.03e-06	2	50	2	25639876
Pubmed	Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.	DNMT3A DNMT3B	2.03e-06	2	50	2	32620778
Pubmed	Centromere mitotic recombination in mammalian cells.	DNMT3A DNMT3B	2.03e-06	2	50	2	18541703
Pubmed	Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis.	DNMT3A DNMT3B	2.03e-06	2	50	2	27476967
Pubmed	Genome-wide DNA Methylation Signatures Are Determined by DNMT3A/B Sequence Preferences.	DNMT3A DNMT3B	2.03e-06	2	50	2	32543182
Pubmed	Do mutations in DNMT3A/3B affect global DNA hypomethylation among benzene-exposed workers in Southeast China?: Effects of mutations in DNMT3A/3B on global DNA hypomethylation.	DNMT3A DNMT3B	2.03e-06	2	50	2	28945286
Pubmed	DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.	DNMT3A DNMT3B	2.03e-06	2	50	2	10555141
Pubmed	Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases.	DNMT3A DNMT3B	2.03e-06	2	50	2	11919202
Pubmed	DNA methyltransferase 3A promoter polymorphism is associated with the risk of human spontaneous abortion after assisted reproduction techniques and natural conception.	DNMT3A DNMT3B	2.03e-06	2	50	2	27817038
Pubmed	Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects.	DNMT3A DNMT3B	2.03e-06	2	50	2	19228594
Pubmed	Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues.	DNMT3A DNMT3B	2.03e-06	2	50	2	31665063
Pubmed	DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation.	DNMT3A DNMT3B	2.03e-06	2	50	2	22190484
Pubmed	Hidden Markov Modelling Reveals Neighborhood Dependence of Dnmt3a and 3b Activity.	DNMT3A DNMT3B	2.03e-06	2	50	2	31027045
Pubmed	B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers.	CD19 DNMT3A	2.03e-06	2	50	2	33850140
Pubmed	Genetic variation in healthy oldest-old.	ING1 DNMT3A DNMT3B	5.54e-06	24	50	3	19680556
Pubmed	Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors.	DNMT3A DNMT3B	6.07e-06	3	50	2	20980350
Pubmed	Expression and regulation of DNA methyltransferases in human endometrium.	DNMT3A DNMT3B	6.07e-06	3	50	2	20970125
Pubmed	Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a.	DNMT3A DNMT3B	6.07e-06	3	50	2	24837369
Pubmed	Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells.	DNMT3A DNMT3B	6.07e-06	3	50	2	15456861
Pubmed	Targeting of 5-aza-2'-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme.	DNMT3A DNMT3B	6.07e-06	3	50	2	20348135
Pubmed	The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium.	DNMT3A DNMT3B	6.07e-06	3	50	2	26808831
Pubmed	Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA.	DNMT3A DNMT3B	6.07e-06	3	50	2	16983096
Pubmed	Mechanism of stimulation of catalytic activity of Dnmt3A and Dnmt3B DNA-(cytosine-C5)-methyltransferases by Dnmt3L.	DNMT3A DNMT3B	6.07e-06	3	50	2	15671018
Pubmed	A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.	DNMT3A DNMT3B	6.07e-06	3	50	2	12138111
Pubmed	Prognostic value of the DNMTs mRNA expression and genetic polymorphisms on the clinical outcome in oral cancer patients.	DNMT3A DNMT3B	6.07e-06	3	50	2	26966018
Pubmed	DNA 5-methylcytosine demethylation activities of the mammalian DNA methyltransferases.	DNMT3A DNMT3B	6.07e-06	3	50	2	23393137
Pubmed	DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells.	DNMT3A DNMT3B	6.07e-06	3	50	2	30321403
Pubmed	The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.	DNMT3A DNMT3B	6.07e-06	3	50	2	18253830
Pubmed	Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion.	DNMT3A DNMT3B	6.07e-06	3	50	2	37979214
Pubmed	Gene-specific timing and epigenetic memory in oocyte imprinting.	DNMT3A DNMT3B	6.07e-06	3	50	2	14998934
Pubmed	Association of increased DNA methyltransferase expression with carcinogenesis and poor prognosis in pancreatic ductal adenocarcinoma.	DNMT3A DNMT3B	6.07e-06	3	50	2	22301400
Pubmed	Co-expression of de novo DNA methyltransferases Dnmt3a2 and Dnmt3L in gonocytes of mouse embryos.	DNMT3A DNMT3B	6.07e-06	3	50	2	15567719
Pubmed	Reduction in DNA methyltransferases and alteration of DNA methylation pattern associate with mouse skin ageing.	DNMT3A DNMT3B	6.07e-06	3	50	2	24645644
Pubmed	Preference of DNA methyltransferases for CpG islands in mouse embryonic stem cells.	DNMT3A DNMT3B	6.07e-06	3	50	2	15310660
Pubmed	De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine.	DNMT3A DNMT3B	6.07e-06	3	50	2	15735669
Pubmed	[Expression of DNMT1, DNMT3a, and DNMT3b in eutopic endometrium].	DNMT3A DNMT3B	6.07e-06	3	50	2	22349384
Pubmed	Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis.	DNMT3A DNMT3B	6.07e-06	3	50	2	24292811
Pubmed	Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers.	DNMT3A DNMT3B	6.07e-06	3	50	2	22520950
Pubmed	Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system.	DNMT3A DNMT3B	6.07e-06	3	50	2	15672446
Pubmed	De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells.	DNMT3A DNMT3B	6.07e-06	3	50	2	34416176
Pubmed	DNA methyltransferase expression in the mouse germ line during periods of de novo methylation.	DNMT3A DNMT3B	6.07e-06	3	50	2	15739230
Pubmed	Dnmt1, Dnmt3a and Dnmt3b cooperate in photoreceptor and outer plexiform layer development in the mammalian retina.	DNMT3A DNMT3B	6.07e-06	3	50	2	27865785
Pubmed	Coordinate regulation of DNA methyltransferase expression during oogenesis.	DNMT3A DNMT3B	6.07e-06	3	50	2	17445268
Pubmed	De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.	DNMT3A DNMT3B	6.07e-06	3	50	2	17420264
Pubmed	The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression.	DNMT3A DNMT3B	6.07e-06	3	50	2	20966256
Pubmed	Interactions within the mammalian DNA methyltransferase family.	DNMT3A DNMT3B	6.07e-06	3	50	2	12777184
Pubmed	Expression and clinicopathological significance of DNA methyltransferase 1, 3A and 3B in tamoxifen-treated breast cancer patients.	DNMT3A DNMT3B	6.07e-06	3	50	2	30359738
Pubmed	Stage-by-stage change in DNA methylation status of Dnmt1 locus during mouse early development.	DNMT3A DNMT3B	6.07e-06	3	50	2	15634679
Pubmed	Epigenetic therapy in urologic cancers: an update on clinical trials.	DNMT3A DNMT3B	6.07e-06	3	50	2	28036257
Interaction	PCDHGC5 interactions	PNPLA6 LTBP1 EPDR1	1.89e-05	22	48	3	int:PCDHGC5
Cytoband	2p22-p21	CAPN13 LTBP1	3.24e-05	8	50	2	2p22-p21
Cytoband	12q13.12	CERS5 DNAJC22	7.97e-04	38	50	2	12q13.12
GeneFamily	Solute carriers	SLCO4C1 SLC25A40 SLCO2B1 SLC25A39 SLCO2A1 SLCO3A1	1.60e-04	395	38	6	752
GeneFamily	C2 domain containing\|Calpains	CAPN13 CAPN5	4.44e-04	15	38	2	975
GeneFamily	PWWP domain containing	DNMT3A DNMT3B	9.68e-04	22	38	2	1147
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC25 DNAJC22	4.75e-03	49	38	2	584
ToppCell	droplet-Spleen-nan-21m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPIN1 ADGRG5 ARSB LAT SLCO3A1	1.63e-06	177	50	5	1381aeb48a4133af060a9e2e7ce08b8b058e12c1
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPIN1 ADGRG5 ARSB LAT SLCO3A1	1.63e-06	177	50	5	6561794ae3b14b5279b249eb5e93b80ef15ed82c
ToppCell	droplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADGRG5 ARSB AVPR1B DNAJC22	3.78e-05	168	50	4	d6078e3a79d315d6090906e171a7d67a9206b2c7
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|390C / Donor, Lineage, Cell class and subclass (all cells)	ADGRG5 LAT CLEC2D PADI6	4.05e-05	171	50	4	d6d8ea45b443d95f64720c9bc07d324148f5b239
ToppCell	facs-Spleen-nan-18m-Lymphocytic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPIN1 ADGRG5 ARSB LAT	4.53e-05	176	50	4	a23d484aff5ad094333b2feae9106ca219514711
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_THTPA\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CAPN13 LTBP1 FREM1 ZNF503-AS2	4.53e-05	176	50	4	e788c7e0b2bfde31fddbf9e04d07140f8b964857
ToppCell	facs-Spleen-nan-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPIN1 ADGRG5 ARSB LAT	4.63e-05	177	50	4	0d894a14ddbb2734557743e9efdb89cee5c26769
ToppCell	droplet-Spleen-SPLEEN-30m-Lymphocytic-mature_NK_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPIN1 ADGRG5 LAT SLCO3A1	4.63e-05	177	50	4	52402ff6299210c46fd9dee3cef203c0eda7a98a
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|390C / Donor, Lineage, Cell class and subclass (all cells)	ADGRG5 LAT CLEC2D PADI6	4.73e-05	178	50	4	375c9449be570b4aed83611f9c6fe1665e677818
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|343B / Donor, Lineage, Cell class and subclass (all cells)	ADGRG5 ZNF775 CLEC2D PEX16	4.84e-05	179	50	4	c09c3eed43d1aa3b7aa8f3021e6f2737840cde16
ToppCell	facs-Spleen-nan-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LPIN1 ADGRG5 LAT SLCO3A1	4.94e-05	180	50	4	407fd8f61a757626e082b6e2eefd3a33276e6b71
ToppCell	3'-Distal_airway-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARSB PNPLA6 SLCO2B1 CTSZ	5.05e-05	181	50	4	166ff44fcc0a2943b7f485ea8a9c314964e013bb
ToppCell	Healthy-HSPC\|World / disease group, cell group and cell class	PRSS21 EPDR1 FREM1 DNMT3B	5.73e-05	187	50	4	8cd9e5499e5c2b2321ecbcf780df37fe0f165ac9
ToppCell	(6)_ILC\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DIPK1C MBOAT7 EPDR1 DNMT3B	5.85e-05	188	50	4	de7cb273899d0e0748c85f45c6b5e7f0642ab057
ToppCell	(6)_ILC\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DIPK1C MBOAT7 EPDR1 DNMT3B	5.85e-05	188	50	4	f4734d5b703678670ece204a0519cf015e180a6e
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	PNPLA6 SLCO2B1 PRSS21 CTSZ	6.10e-05	190	50	4	6514f00d222eef08c282face7f177259bca62f0e
ToppCell	(3)_Macrophage_MARCOpos\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	PNPLA6 SLCO2B1 PRSS21 CTSZ	6.35e-05	192	50	4	b1e2175bd4c02106e52d8f491eea1329ac327ae9
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_4\|343B / Donor, Lineage, Cell class and subclass (all cells)	PNPLA6 SLCO2B1 PRSS21 CTSZ	6.48e-05	193	50	4	b9dcffd28ca309359fb110fb79de8ce066208ee1
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage\|367C / Donor, Lineage, Cell class and subclass (all cells)	PNPLA6 SLCO2B1 PRSS21 CTSZ	6.61e-05	194	50	4	40c91ed945bd5990a0dbf2090d37a660b19aaab2
ToppCell	343B-Myeloid-Macrophage\|343B / Donor, Lineage, Cell class and subclass (all cells)	PNPLA6 SLCO2B1 PRSS21 CTSZ	6.74e-05	195	50	4	48ba2044d2459c8b0d17bc7deca8d0195ac6a00e
ToppCell	367C-Myeloid-Macrophage\|367C / Donor, Lineage, Cell class and subclass (all cells)	PNPLA6 SLCO2B1 PRSS21 CTSZ	6.74e-05	195	50	4	77cd831a5da5ab1751499db541f318faf925e527
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.4.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PNPLA6 SLCO2B1 PRSS21 CTSZ	6.88e-05	196	50	4	eb7d6bbfb766cdeaf5fe0f0bb66a5f491fd5ef26
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-ILC\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADAMTS10 ADGRG5 DIPK1C DNMT3B	6.88e-05	196	50	4	1cc2b11764584129703ec61965e8ec4e051464e7
ToppCell	Fetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PNPLA6 SLCO2B1 PRSS21 CTSZ	7.15e-05	198	50	4	ab70bf89690410221ec7aa3149bb50ac34433f99
ToppCell	Bronchial-10x5prime-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD11d\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRG5 LAT SLCO4C1 CLEC2D	7.29e-05	199	50	4	ed460ff7fb82d3f0eed689d56f50d40514f74b48
ToppCell	Transverse-T_cell-Tfh\|T_cell / Region, Cell class and subclass	ZNF775 PNPLA6 AAMDC CAPN5	7.29e-05	199	50	4	33ffea12b8228e0b5bd8942531c3b21d24224725
ToppCell	Caecum-ILC\|Caecum / Region, Cell class and subclass	DIPK1C MBOAT7 EPDR1 DNMT3B	7.44e-05	200	50	4	a9a1f03b4f415da860fb52eaedb07f0743692c98
ToppCell	Caecum-(3)_ILC-(30)_ILC\|Caecum / shred on region, Cell_type, and subtype	DIPK1C MBOAT7 EPDR1 DNMT3B	7.44e-05	200	50	4	ccd323997613b65f0189c0c66d76fbf273e18c03
ToppCell	Caecum-ILC-ILC\|Caecum / Region, Cell class and subclass	DIPK1C MBOAT7 EPDR1 DNMT3B	7.44e-05	200	50	4	3ac18c3ef335cb83d6a826f6c7519a5e7804929d
ToppCell	Parenchyma_COVID-19-Immune-TX-TRAM-1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	PNPLA6 SLCO2B1 PRSS21 CTSZ	7.44e-05	200	50	4	0a7addc5b2f3f3d91d93bf9d1a466c2acfbcc5de
ToppCell	Caecum-(3)_ILC\|Caecum / shred on region, Cell_type, and subtype	DIPK1C MBOAT7 EPDR1 DNMT3B	7.44e-05	200	50	4	6857863b3200162c250123688af2cba681afcb35
Disease	endometriosis of uterus (is_marker_for)	DNMT3A DNMT3B	8.10e-06	3	49	2	DOID:288 (is_marker_for)
Disease	congenital heart disease (biomarker_via_orthology)	DNMT3A DNMT3B	1.62e-05	4	49	2	DOID:1682 (biomarker_via_orthology)
Disease	prostatitis (biomarker_via_orthology)	DNMT3A DNMT3B	1.76e-04	12	49	2	DOID:14654 (biomarker_via_orthology)
Disease	autoimmune thrombocytopenic purpura (is_marker_for)	DNMT3A DNMT3B	2.08e-04	13	49	2	DOID:8924 (is_marker_for)
Disease	head and neck squamous cell carcinoma (is_implicated_in)	ING1 DNMT3B	2.80e-04	15	49	2	DOID:5520 (is_implicated_in)
Disease	body weights and measures, body height	ADAMTS10 LMAN2	2.80e-04	15	49	2	EFO_0004324, EFO_0004339
Disease	endometriosis (is_marker_for)	DNMT3A DNMT3B	7.91e-04	25	49	2	DOID:289 (is_marker_for)
Disease	chronic myeloid leukemia (is_marker_for)	DNMT3A DNMT3B	9.23e-04	27	49	2	DOID:8552 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WGRWRGRPIHLGLWV	nan	131	A8MZ25
CKVWPGGSRTWDWRE	AAMDC	26	Q9H7C9
PGALGAWLLGGLWAW	EPDR1	11	Q9UM22
NSWGEPWGERGWLRI	CTSZ	261	Q9UBR2
VWGKLRGFSWWPGRI	DNMT3A	296	Q9Y6K1
GDLVWGKIKGFSWWP	DNMT3B	226	Q9UBC3
MPGKRGLGWWWARLP	GRM4	1	Q14833
LWNPWGWGEAEWRGR	CAPN13	271	Q6MZZ7
RLRNPWGEREWNGPW	CAPN5	281	O15484
QGPLSLLWGWLWSER	CERS5	6	Q8N5B7
VRDEKPWKGRPWWLR	ADAMTS10	196	Q9H324
KKWIWGPSGWGAILL	PADI6	146	Q6TGC4
GDSLSGWWLLWKRLN	PNPLA6	1171	Q8IY17
WIWRWGWGRRCLGRP	LMAN2	6	Q12907
AQAGWGVWGPSWTRL	LAT	121	O43561
MAGAWLRWGLLLWAG	LTBP1	1	Q14766
MGPRQGRWWLLLWLP	NEMP2	1	A6NFY4
WLWDIGGRKSFWIGL	FREM1	2101	Q5H8C1
RGPWARGWKSLWTGL	RSKR	31	Q96LW2
MPKKGGRWWFSWRGR	LPIN1	546	Q14693
RLSPGGQKAWDWVHW	MBOAT7	386	Q96N66
LSPGWGAGAAGRRWW	DNAJC25	6	Q9H1X3
ARPVLWHWLLRTGGW	CD19	276	P15391
LAGGNNWPLRGRKWS	ARSB	306	P15848
NWPLRGRKWSLWEGG	ARSB	311	P15848
GGLGWLWEFWKLPSF	DNAJC22	41	Q8N4W6
SYSPRWKGRWANDGW	SCAF11	961	Q99590
WKGRWANDGWRCPRG	SCAF11	966	Q99590
WWPGRRGPRWRGQLA	DIPK1C	171	Q0P6D2
GLWGQRSWKPWLLAG	PEX16	236	Q9Y5Y5
DDPRWIGAWWGGFLL	SLCO3A1	256	Q9UIG8
GWISLWRGWAPTVLR	SLC25A40	191	Q8TBP6
DFWGKESLWGRSVWP	FER1L5	1156	A0AVI2
TGWWPCQVLDGGKWR	FER1L5	1881	A0AVI2
LLTRGWGRAWPWKQI	ING1	176	Q9UK53
CWGLGRAWPEGARWE	KCP	96	Q6ZWJ8
FWKEGARKQPWGGWS	ADGRG5	191	Q8IZF4
HWIGLSREQGQPWKW	CLEC2D	131	Q9UHP7
REWLETAGPWGQAAW	C15orf39	791	Q6ZRI6
PRWIGAWWLGLLISS	SLCO2A1	251	Q92959
IRWRLWKAHEGWGGG	ZNF503-AS2	166	A6NEH8
AWRVGGGGWRTWDRP	AVPR1B	236	P47901
WRKRAENDGWETWGG	REV1	6	Q9UBZ9
AVAQGGWRSLWLGWG	SLC25A39	206	Q9BZJ4
GWRSLWLGWGPTALR	SLC25A39	211	Q9BZJ4
RTWAGWGAWELLNPA	MRPL54	11	Q6P161
TIKDPRWVGAWWLGF	SLCO2B1	266	O94956
DDPRWLGAWWIGFLL	SLCO4C1	306	Q6ZQN7
GRPEWAWLGLCQGWW	ZNF775	246	Q96BV0
WRPWWWNRGAGPQLL	ZNHIT2	126	Q9UHR6
LWKAWAGWGSKRPLA	PIGO	526	Q8TEQ8
GRWPWQGSLRLWDSH	PRSS21	51	Q9Y6M0
FWVWKSLARGWPRGL	VRTN	541	Q9H8Y1
MGPWPRDWLGKGWRL	nan	1	Q6ZVH6
AGGAGGTWWRRWQPR	KCNC3	261	Q14003
GTAGRDGDRGWGKWW	NEXN-AS1	26	Q8NBZ9
DGDRGWGKWWGTALN	NEXN-AS1	31	Q8NBZ9