Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF729 ZNF485 ZNF717 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77 KLF2

4.04e-2014122922GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF729 ZNF485 ZNF717 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77 KLF2

8.21e-2014592922GO:0000977
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF729 ZNF485 ZNF717 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF600 ZNF773 ZNF154 ZNF626 ZNF670 KLF2

7.33e-1412442917GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF729 ZNF485 ZNF717 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF600 ZNF773 ZNF154 ZNF626 ZNF670 KLF2

1.04e-1312712917GO:0000987
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

ZNF729 ZNF485 ZNF717 ZNF814 ZNF624 ZNF808 ZNF600

1.20e-05560297GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

ZNF729 ZNF485 ZNF717 ZNF814 ZNF624 ZNF808 ZNF600

1.28e-05566297GO:0001216
GeneOntologyMolecularFunctionSMAD binding

BMPR1A AXIN2

6.90e-0386292GO:0046332
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity, RNA polymerase II-specific

ZNF729 ZNF134 ZNF670

1.09e-02320293GO:0001227
GeneOntologyMolecularFunctionDNA-binding transcription repressor activity

ZNF729 ZNF134 ZNF670

1.15e-02326293GO:0001217
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

ZNF729 ZNF485 ZNF462 ZNF717 ZNF814 ZNF808 BMPR1A ZNF600 KLF2

8.14e-051390299GO:0045944
GeneOntologyBiologicalProcessmitral valve morphogenesis

BMPR1A AXIN2

1.98e-0415292GO:0003183
GeneOntologyBiologicalProcessmitral valve development

BMPR1A AXIN2

2.26e-0416292GO:0003174
GeneOntologyBiologicalProcessdorsal/ventral axis specification

BMPR1A AXIN2

2.26e-0416292GO:0009950
HumanPhenoAdenomatous colonic polyposis

BMPR1A AXIN2

6.27e-051742HP:0005227
HumanPhenoColorectal polyposis

BMPR1A AXIN2

1.27e-042442HP:0200063
HumanPhenoLarge intestinal polyposis

BMPR1A AXIN2

2.28e-043242HP:0030255
HumanPhenoColon cancer

BMPR1A AXIN2

3.39e-043942HP:0003003
HumanPhenoNeoplasm of the rectum

BMPR1A AXIN2

4.73e-044642HP:0100743
HumanPhenoIntestinal polyposis

BMPR1A AXIN2

8.61e-046242HP:0200008
HumanPhenoIntestinal polyp

BMPR1A AXIN2

1.01e-036742HP:0005266
HumanPhenoUterine neoplasm

BMPR1A AXIN2

1.16e-037242HP:0010784
HumanPhenoMalignant gastrointestinal tract tumors

BMPR1A AXIN2

1.26e-037542HP:0006749
HumanPhenoGastrointestinal carcinoma

BMPR1A AXIN2

1.26e-037542HP:0002672
HumanPhenoFemale reproductive system neoplasm

BMPR1A AXIN2

1.29e-037642HP:0033020
HumanPhenoIntellectual disability, mild

ZNF462 ZMYM2 BMPR1A

1.38e-0336543HP:0001256
HumanPhenoObstructive sleep apnea

ZNF462 ZMYM2

1.40e-037942HP:0002870
HumanPhenoNeoplasm of the colon

BMPR1A AXIN2

1.47e-038142HP:0100273
HumanPhenoNeoplasm of the breast

BMPR1A AXIN2

1.89e-039242HP:0100013
HumanPhenoAbnormal thumb morphology

ZNF462 ZMYM2 BMPR1A

1.92e-0340843HP:0001172
Domain-

ZNF729 ZNF485 ZNF462 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77 KLF2

4.73e-2767928223.30.160.60
Domainzf-C2H2

ZNF729 ZNF485 ZNF462 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77 KLF2

7.43e-276932822PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF729 ZNF485 ZNF462 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77 KLF2

7.68e-276942822IPR013087
DomainZINC_FINGER_C2H2_2

ZNF729 ZNF485 ZNF462 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77 KLF2

8.79e-267752822PS50157
DomainZINC_FINGER_C2H2_1

ZNF729 ZNF485 ZNF462 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77 KLF2

9.31e-267772822PS00028
DomainZnf_C2H2-like

ZNF729 ZNF485 ZNF462 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77 KLF2

1.59e-257962822IPR015880
DomainZnf_C2H2

ZNF729 ZNF485 ZNF462 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77 KLF2

2.03e-258052822IPR007087
DomainZnF_C2H2

ZNF729 ZNF485 ZNF462 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77 KLF2

2.20e-258082822SM00355
DomainKRAB

ZNF729 ZNF485 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF627 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77

8.78e-253582818PS50805
DomainKRAB

ZNF729 ZNF485 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF627 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77

8.78e-253582818PF01352
DomainKRAB

ZNF729 ZNF485 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF627 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77

1.53e-243692818SM00349
DomainKRAB

ZNF729 ZNF485 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF627 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77

1.60e-243702818IPR001909
Domainzf-C2H2_6

ZNF729 ZNF506 ZNF12 ZNF814 ZNF624 ZNF808 ZNF616 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77

8.07e-243142817PF13912
DomainZnF_C2HC

ZNF34 ZCRB1

3.06e-0355282SM00343
DomainZnf_CCHC

ZNF34 ZCRB1

3.06e-0355282IPR001878
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

ZNF729 ZNF485 ZNF717 ZNF506 ZNF12 ZNF34 ZNF624 ZNF616 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77

1.33e-1213872718M734
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

ZNF729 ZNF12 ZNF814 ZNF624 ZNF808 ZNF616 ZNF773 ZNF670 ZNF442

7.78e-06768279MM14851
PathwayREACTOME_GENE_EXPRESSION_TRANSCRIPTION

ZNF729 ZNF12 ZNF814 ZNF624 ZNF808 ZNF616 ZNF773 ZNF670 ZNF442

7.58e-051022279MM15436
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF485 ZNF34 ZNF624 ZNF627 ZNF555 ZNF626 ZNF670 ZNF77

1.80e-1218129837372979
Pubmed

Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.

ZNF729 ZNF814 ZNF624 ZNF616 ZNF670

5.21e-10492959630514
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZNF729 ZNF462 ZNF506 ZMYM2 ZNF616 ZNF773 ZNF626 ZNF670 KLF2

1.25e-0880829920412781
Pubmed

Axin2-expressing cells in the periodontal ligament are regulated by bone morphogenetic protein signalling and play a pivotal role in periodontium development.

BMPR1A AXIN2

6.71e-07229235634660
Pubmed

Axin2-CreERT2 mediated knockout of bone morphogenetic protein receptor type 1A caused abnormal secondary dentine and altered cell fate of Axin2-expressing odontogenic cells.

BMPR1A AXIN2

6.71e-07229237191048
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF729 ZNF506 ZNF626

1.88e-062929314563677
Pubmed

miR-29a/b1 Inhibits Hair Follicle Stem Cell Lineage Progression by Spatiotemporally Suppressing WNT and BMP Signaling.

BMPR1A AXIN2

1.41e-05729231747615
Pubmed

Specific and ubiquitous expression of different Zn finger protein genes in the mouse.

ZNF814 ZNF624

1.41e-0572923143103
Pubmed

Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.

ZNF814 ZNF624 ZNF616

1.73e-056029318023262
Pubmed

Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.

AXIN2 KLF2

2.41e-05929231844321
Pubmed

Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.

BMPR1A AXIN2

5.21e-051329212923052
Pubmed

Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo.

BMPR1A AXIN2

8.00e-051629220211162
Pubmed

Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.

AXIN2 KLF2

8.00e-051629229056552
Pubmed

Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

ZNF134 ZNF154

9.06e-05172927557990
Pubmed

Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.

ZNF814 ZNF624

1.26e-04202922542606
Pubmed

Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.

ZNF814 ZNF624

1.26e-04202927479878
Pubmed

Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2.

BMPR1A AXIN2

1.26e-042029221303850
Pubmed

Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.

BMPR1A AXIN2

1.40e-042129218000065
Pubmed

Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos.

BMPR1A AXIN2

1.40e-042129231038803
Pubmed

BMP-FGF signaling axis mediates Wnt-induced epidermal stratification in developing mammalian skin.

BMPR1A AXIN2

1.53e-042229225329657
Pubmed

Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors.

BMPR1A AXIN2

2.33e-042729232878924
Pubmed

Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.

ZNF600 ZNF670

3.28e-043229226142281
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

ZNF485 ZNF462 ZMYM2 ZNF12 ZNF808 ZNF773

4.06e-04120329629180619
Pubmed

Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric mesenchyme by balancing SHH and BMP4 signaling.

BMPR1A AXIN2

4.39e-043729236094016
Pubmed

Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b.

BMPR1A AXIN2

4.88e-043929223341776
Pubmed

Gpr177 regulates pulmonary vasculature development.

AXIN2 KLF2

6.21e-044429223884445
InteractionTRIM28 interactions

ZNF485 ZNF462 ZNF12 ZNF34 ZNF624 ZNF808 ZNF616 ZNF627 ZNF600 ZNF773 ZNF555 ZNF626 ZNF670 ZNF77

1.78e-0914742814int:TRIM28
InteractionLTBP2 interactions

ZNF12 ZNF624 ZNF627 ZNF555 ZNF77

1.08e-0785285int:LTBP2
CytobandEnsembl 112 genes in cytogenetic band chr19p13

ZNF506 ZNF627 ZNF555 ZNF700 ZNF442 ZNF77 KLF2

5.18e-07797297chr19p13
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF814 ZNF808 ZNF616 ZNF134 ZNF600 ZNF773 ZNF154

7.40e-061192297chr19q13
Cytoband19q13.41

ZNF808 ZNF616 ZNF600

1.67e-057829319q13.41
Cytoband19p13.2

ZNF627 ZNF700 ZNF442

4.07e-0422929319p13.2
Cytoband19p13.11

ZNF506 KLF2

9.85e-047329219p13.11
Cytoband19q13.4

ZNF134 ZNF154

1.15e-037929219q13.4
Cytoband19q13.43

ZNF814 ZNF773

1.39e-038729219q13.43
Cytoband19p12

ZNF729 ZNF626

1.49e-039029219p12
CytobandEnsembl 112 genes in cytogenetic band chr19p12

ZNF729 ZNF626

2.71e-03122292chr19p12
Cytoband19p13.3

ZNF555 ZNF77

9.83e-0323729219p13.3
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF729 ZNF485 ZNF462 ZNF717 ZNF506 ZNF12 ZNF814 ZNF34 ZNF624 ZNF808 ZNF616 ZNF134 ZNF627 ZNF600 ZNF773 ZNF555 ZNF154 ZNF700 ZNF626 ZNF670 ZNF442 ZNF77 KLF2

3.45e-28718282328
ToppCell356C-Lymphocytic-NK_cells-NK_cell_E|356C / Donor, Lineage, Cell class and subclass (all cells)

ZNF485 ZNF616 BMPR1A ZNF773

3.76e-06164294d5bb57c321f2973836efc8990449494cc1fb87c7
ToppCell356C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF485 ZNF616 BMPR1A ZNF773

4.65e-06173294090dc3c5bd2652a65c2490fc889da858c3af368f
ToppCell356C-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZNF485 ZNF616 BMPR1A ZNF773

4.76e-06174294a79ebb01a5849c314e02594a9c95009dbb03cb8c
ToppCell343B-Fibroblasts-Fibroblast-E|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZNF506 ZNF624 ZNF616 AXIN2

6.06e-0618529402cbf492bc40abebaa93a3a208888afae72fbe06
ToppCell343B-Fibroblasts-Fibroblast-E-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZNF506 ZNF624 ZNF616 AXIN2

6.06e-061852941b8e3ddb91797f84e4b15d2457b0c008e5be50db
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ZNF814 TRIM34 ZNF555 ZNF670

7.77e-06197294fd76cc5e12c7e7943a48f739e4f0626ff7211f51
ToppCellTransverse-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

ZNF624 ZNF616 ZNF700 ZNF670

8.09e-06199294fd75dccb37d96448edf72b7d042b06833d4ead24
DiseaseColorectal Carcinoma

ZNF624 BMPR1A ZNF442 AXIN2 KLF2

3.93e-04702275C0009402

Protein segments in the cluster

PeptideGeneStartEntry
GSEYYCYSKCKSHSK

AXIN2

546

Q9Y2T1
TCSLKGHYCLYSKSS

VEPH1

591

Q14D04
SSCFCYKHYCKSISS

BMPR1A

171

P36894
SHGSLIYKFSKCCFS

TRIM34

451

Q9BYJ4
KCYDCGKSFRTKSYL

ZNF624

641

Q9P2J8
TYKCKFCGKAFHSFS

ZNF700

221

Q9H0M5
YECKHCGKSFSCYSS

ZNF77

296

Q15935
TYKCNKCGKVYSKHS

ZNF616

436

Q08AN1
YKCKECGKAFSYSST

ZNF555

256

Q8NEP9
YKCNECGKTFSYKSS

ZNF808

651

Q8N4W9
YKCTKCGKAFSRSSY

ZNF627

391

Q7L945
YKCSECGKFYSHKSS

ZNF773

331

Q6PK81
YKCEECGKAFKYSST

ZNF626

341

Q68DY1
YCSTACMNSHKTKYA

ZMYM2

561

Q9UBW7
ACNECGKTYSHKSYL

ZNF717

536

Q9BY31
ECKHCSKAFPDYSSY

ZNF442

266

Q9H7R0
YFDKSKCYECGESGH

ZCRB1

101

Q8TBF4
KCKDCSFYTGFKSAF

ZNF462

2221

Q96JM2
YECTECGKKFYHKSA

ZNF12

661

P17014
YICSECGKSFSKSYS

ZNF154

161

Q13106
YKCKVCDKTFGSDSH

ZNF600

666

Q6ZNG1
YHCSKCGKSFRYSSS

ZNF485

326

Q8NCK3
YDCSDCGKSFGHKYT

ZNF134

316

P52741
YKCEECGKAYKQSSH

ZNF506

201

Q5JVG8
HYECGECGKSFSKYV

ZNF814

351

B7Z6K7
YTGEKTYKCKHCDKA

ZNF670

191

Q9BS34
TYKCKHCDKAFNYSS

ZNF670

196

Q9BS34
TGKKLHYCSYCGKTF

ZNF34

246

Q8IZ26
YKYKKCGNAFKFSST

ZNF729

236

A6NN14
THTCSYAGCGKTYTK

KLF2

271

Q9Y5W3