Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	helicase activity	DDX12P DDX60 ZGRF1 CHD8 DHX30 MOV10	1.22e-04	158	97	6	GO:0004386
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR3	1.39e-04	4	97	2	GO:0005219
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	DDX12P DDX60 DHX30 POLR1D TRMT2A INTS11 CMTR2 CPSF3 MOV10	1.96e-04	417	97	9	GO:0140098
GeneOntologyMolecularFunction	DNA helicase activity	DDX12P ZGRF1 CHD8 DHX30	2.35e-04	62	97	4	GO:0003678
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	DDX12P DDX60 ZGRF1 CHD8 DHX30 POLR1D TRMT2A INTS11 CMTR2 CPSF3 MOV10	2.94e-04	645	97	11	GO:0140640
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR3	3.46e-04	6	97	2	GO:0048763
GeneOntologyMolecularFunction	RNA helicase activity	DDX12P DDX60 DHX30 MOV10	5.67e-04	78	97	4	GO:0003724
GeneOntologyMolecularFunction	ATP-dependent activity, acting on RNA	DDX12P DDX60 DHX30 MOV10	6.24e-04	80	97	4	GO:0008186
HumanPheno	Noncommunicating hydrocephalus	BICRA TSC2 FOXJ1	1.63e-05	8	35	3	HP:0010953
Domain	RMMBL	INTS11 CPSF3	7.82e-05	3	96	2	IPR011108
Domain	Ryanrecept_TM4-6	RYR1 RYR3	7.82e-05	3	96	2	IPR009460
Domain	RyR	RYR1 RYR3	7.82e-05	3	96	2	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR3	7.82e-05	3	96	2	IPR003032
Domain	RR_TM4-6	RYR1 RYR3	7.82e-05	3	96	2	PF06459
Domain	RMMBL	INTS11 CPSF3	7.82e-05	3	96	2	PF07521
Domain	Ryan_recept	RYR1 RYR3	7.82e-05	3	96	2	IPR013333
Domain	Beta-Casp	INTS11 CPSF3	1.56e-04	4	96	2	PF10996
Domain	RetinoicA-induced_16-like	FHIP2A FHIP2B	1.56e-04	4	96	2	IPR019384
Domain	RAI16-like	FHIP2A FHIP2B	1.56e-04	4	96	2	PF10257
Domain	Beta_Casp	INTS11 CPSF3	1.56e-04	4	96	2	IPR022712
Domain	Beta-Casp	INTS11 CPSF3	1.56e-04	4	96	2	SM01027
Domain	LRR_6	CARMIL1 NLRP3 CIITA NLRC5	1.83e-04	55	96	4	PF13516
Domain	NACHT	NLRP3 CIITA NLRC5	2.16e-04	23	96	3	PS50837
Domain	NACHT_NTPase	NLRP3 CIITA NLRC5	2.16e-04	23	96	3	IPR007111
Domain	RIH_assoc	RYR1 RYR3	3.87e-04	6	96	2	PF08454
Domain	RIH_assoc-dom	RYR1 RYR3	3.87e-04	6	96	2	IPR013662
Domain	RIH_dom	RYR1 RYR3	3.87e-04	6	96	2	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR3	3.87e-04	6	96	2	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR3	3.87e-04	6	96	2	IPR015925
Domain	-	RYR1 RYR3	3.87e-04	6	96	2	1.25.10.30
Domain	RYDR_ITPR	RYR1 RYR3	3.87e-04	6	96	2	PF01365
Domain	Ins145_P3_rec	RYR1 RYR3	3.87e-04	6	96	2	PF08709
Domain	DHC_N1	DYNC2H1 DNAH5	7.17e-04	8	96	2	PF08385
Domain	Dynein_heavy_dom-1	DYNC2H1 DNAH5	7.17e-04	8	96	2	IPR013594
Domain	MIR	RYR1 RYR3	1.15e-03	10	96	2	PS50919
Domain	MIR	RYR1 RYR3	1.15e-03	10	96	2	PF02815
Domain	MIR	RYR1 RYR3	1.15e-03	10	96	2	SM00472
Domain	MIR_motif	RYR1 RYR3	1.15e-03	10	96	2	IPR016093
Domain	Lactamase_B	INTS11 CPSF3	1.97e-03	13	96	2	PF00753
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH5	2.29e-03	14	96	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH5	2.29e-03	14	96	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH5	2.29e-03	14	96	2	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH5	2.29e-03	14	96	2	PF08393
Domain	MT	DYNC2H1 DNAH5	2.29e-03	14	96	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH5	2.29e-03	14	96	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DYNC2H1 DNAH5	2.29e-03	14	96	2	IPR011704
Domain	-	TRAF3 PDZRN4	2.29e-03	14	96	2	3.90.890.10
Domain	AAA_5	DYNC2H1 DNAH5	2.29e-03	14	96	2	PF07728
Domain	DHC_fam	DYNC2H1 DNAH5	2.63e-03	15	96	2	IPR026983
Domain	CRYSTALLIN_BETA_GAMMA	CRYGC CRYBG3	2.63e-03	15	96	2	PS50915
Domain	Lactamase_B	INTS11 CPSF3	2.63e-03	15	96	2	SM00849
Domain	Dynein_heavy_dom	DYNC2H1 DNAH5	2.63e-03	15	96	2	IPR004273
Domain	Crystall	CRYGC CRYBG3	2.63e-03	15	96	2	PF00030
Domain	Beta/gamma_crystallin	CRYGC CRYBG3	2.63e-03	15	96	2	IPR001064
Domain	Dynein_heavy	DYNC2H1 DNAH5	2.63e-03	15	96	2	PF03028
Domain	XTALbg	CRYGC CRYBG3	2.63e-03	15	96	2	SM00247
Domain	Leu-rich_rpt	CARMIL1 CHADL NLRP3 AMIGO3 CIITA NLRC5	2.75e-03	271	96	6	IPR001611
Domain	SIAH-type	TRAF3 PDZRN4	2.99e-03	16	96	2	IPR013323
Domain	G_crystallin-rel	CRYGC CRYBG3	3.79e-03	18	96	2	IPR011024
Domain	-	INTS11 CPSF3	4.68e-03	20	96	2	3.60.15.10
Domain	Metallo-B-lactamas	INTS11 CPSF3	4.68e-03	20	96	2	IPR001279
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 BCAS3 BICRA GRB10 CHD8 TSC2 FRYL EML3 RYR1 DHX30 MROH6 INTS11 NLRC5 STK40 C1orf50 PPP1R16A	7.97e-08	1105	98	16	35748872
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CUL2 GGNBP2 ATR TBC1D5 NOL6 ZNF629 CHD8 FHIP2A TRMT2A ELP2 CRYBG3 CMTR2	3.09e-07	650	98	12	38777146
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	DYNC2H1 DNAH5 FOXJ1	6.08e-06	13	98	3	17884984
Pubmed	FAM160B1 deficit associated with microcephaly, severe intellectual disability, ataxia, behavioral abnormalities and speech problems.	FHIP2A FHIP2B	7.86e-06	2	98	2	31353455
Pubmed	NLR family member NLRC5 is a transcriptional regulator of MHC class I genes.	CIITA NLRC5	7.86e-06	2	98	2	20639463
Pubmed	NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity.	CIITA NLRC5	7.86e-06	2	98	2	37108368
Pubmed	MF-094, a potent and selective USP30 inhibitor, accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome.	USP30 NLRP3	7.86e-06	2	98	2	34883112
Pubmed	Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.	RYR1 RYR3	7.86e-06	2	98	2	12565913
Pubmed	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.	RYR1 RYR3	7.86e-06	2	98	2	9489997
Pubmed	Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells.	NLRP3 NLRC5	7.86e-06	2	98	2	23815151
Pubmed	Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.	RYR1 RYR3	7.86e-06	2	98	2	9192302
Pubmed	The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.	RYR1 RYR3	7.86e-06	2	98	2	12640042
Pubmed	Microglial ASD-related genes are involved in oligodendrocyte differentiation.	CHD8 TSC2	7.86e-06	2	98	2	34497307
Pubmed	Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.	RYR1 RYR3	7.86e-06	2	98	2	7556644
Pubmed	Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.	RYR1 RYR3	7.86e-06	2	98	2	14592949
Pubmed	ATR couples FANCD2 monoubiquitination to the DNA-damage response.	ATR FANCD2	7.86e-06	2	98	2	15314022
Pubmed	Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.	RYR1 RYR3	7.86e-06	2	98	2	15894801
Pubmed	NLRC5: a key regulator of MHC class I-dependent immune responses.	CIITA NLRC5	7.86e-06	2	98	2	23175229
Pubmed	Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.	RYR1 RYR3	7.86e-06	2	98	2	9799464
Pubmed	Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.	RYR1 RYR3	7.86e-06	2	98	2	9817784
Pubmed	Cutting edge: impaired MHC class I expression in mice deficient for Nlrc5/class I transactivator.	CIITA NLRC5	7.86e-06	2	98	2	22711889
Pubmed	Regulation of class I major histocompatibility complex (MHC) by nucleotide-binding domain, leucine-rich repeat-containing (NLR) proteins.	CIITA NLRC5	7.86e-06	2	98	2	22645137
Pubmed	An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11.	INTS11 CPSF3	7.86e-06	2	98	2	36822327
Pubmed	Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.	RYR1 RYR3	7.86e-06	2	98	2	17118445
Pubmed	RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.	RYR1 RYR3	7.86e-06	2	98	2	11500519
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	CHD8 FHIP2A ZFYVE28 DNAH5 MOV10	1.02e-05	101	98	5	10997877
Pubmed	The trefoil gene maps to mouse chromosome 17.	SIK1 TSC2	2.35e-05	3	98	2	9072957
Pubmed	FYVE domain-containing protein ZFYVE28 regulates EGFR-signaling in podocytes but is not critical for the function of filtration barrier in mice.	ZFYVE28 TH	2.35e-05	3	98	2	29549365
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR3	2.35e-05	3	98	2	18403125
Pubmed	Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.	RYR1 RYR3	2.35e-05	3	98	2	11171121
Pubmed	Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.	RYR1 RYR3	2.35e-05	3	98	2	18313230
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR3	2.35e-05	3	98	2	18434746
Pubmed	NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module.	CIITA NLRC5	2.35e-05	3	98	2	25811463
Pubmed	Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance.	ATR FANCD2	2.35e-05	3	98	2	16943440
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR3	2.35e-05	3	98	2	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR3	2.35e-05	3	98	2	7876312
Pubmed	Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination.	ATR FANCD2	2.35e-05	3	98	2	34828369
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR3	2.35e-05	3	98	2	21881589
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR3	2.35e-05	3	98	2	12213830
Pubmed	Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence.	ATR FANCD2	2.35e-05	3	98	2	21995812
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR3	2.35e-05	3	98	2	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR3	2.35e-05	3	98	2	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR3	2.35e-05	3	98	2	10788707
Pubmed	Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2.	ATR FANCD2	2.35e-05	3	98	2	31067464
Pubmed	The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis.	NLRP3 NLRC5	2.35e-05	3	98	2	31186034
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR3	2.35e-05	3	98	2	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR3	2.35e-05	3	98	2	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR3	2.35e-05	3	98	2	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR3	2.35e-05	3	98	2	11159936
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR3	2.35e-05	3	98	2	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR3	2.35e-05	3	98	2	7959768
Pubmed	Mechanism of inflammasome activation by SARS coronavirus 3a protein: abridged secondary publication.	TRAF3 NLRP3	2.35e-05	3	98	2	34075889
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR3	2.35e-05	3	98	2	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR3	2.35e-05	3	98	2	7635066
Pubmed	Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.	GALNT14 ZFP90 BICRA	2.39e-05	20	98	3	22174851
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 RYR3	4.70e-05	4	98	2	22100703
Pubmed	The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-β1-induced BEAS-2B Cell Injury.	TRAF3 NLRP3	4.70e-05	4	98	2	36976509
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR3	4.70e-05	4	98	2	18206662
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR3	4.70e-05	4	98	2	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR3	4.70e-05	4	98	2	9384575
Pubmed	The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways.	ATR FANCD2	4.70e-05	4	98	2	14988723
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR3	4.70e-05	4	98	2	9607712
Pubmed	FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.	ATR FANCD2	4.70e-05	4	98	2	18931676
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR3	4.70e-05	4	98	2	23482488
Pubmed	Human transcription factor protein interaction networks.	CUL2 HSPG2 TRAF3 CAD BICRA ZNF629 CHD8 PRDM2 DHX30 TIMM10B STK40 ZNF319 USP27X MOV10	4.75e-05	1429	98	14	35140242
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	CUL2 TM9SF1 NOL6 AGPS FANCD2 TIMM10B TRMT2A C1orf50 CPSF3 MOV10	5.44e-05	754	98	10	33060197
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	CAD DDX60 ZGRF1 DHX30 DNAH5 VPS13B	5.47e-05	234	98	6	36243803
Pubmed	Same but different - Molecular comparison of human KTI12 and PSTK.	NUP43 ELP2 CRYBG3	6.04e-05	27	98	3	33417976
Pubmed	Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product.	NLRP3 NLRC5	7.82e-05	5	98	2	12615073
Pubmed	NLRC5 restricts dengue virus infection by promoting the autophagic degradation of viral NS3 through E3 ligase CUL2 (cullin 2).	CUL2 NLRC5	7.82e-05	5	98	2	36126167
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR3	7.82e-05	5	98	2	23918386
Pubmed	Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells.	DNAH5 FOXJ1	7.82e-05	5	98	2	25712475
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR3	7.82e-05	5	98	2	19011160
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR3	1.17e-04	6	98	2	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR3	1.17e-04	6	98	2	26025922
Pubmed	Genetic mouse models of autism spectrum disorder present subtle heterogenous cardiac abnormalities.	CHD8 VPS13B	1.17e-04	6	98	2	35445787
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR3	1.17e-04	6	98	2	23463619
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	RYR1 RYR3	1.17e-04	6	98	2	10444070
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR3	1.17e-04	6	98	2	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR3	1.17e-04	6	98	2	20519450
Pubmed	ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway.	ATR FANCD2	1.17e-04	6	98	2	22258451
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR3	1.17e-04	6	98	2	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR3	1.17e-04	6	98	2	19009018
Pubmed	Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons.	SIM1 TH	1.17e-04	6	98	2	21541283
Pubmed	ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.	ATR TSC2	1.17e-04	6	98	2	30297842
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR3	1.17e-04	6	98	2	16844763
Pubmed	Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.	SIK1 MELK	1.17e-04	6	98	2	21985311
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	CAD CHD8 PRDM2 RYR3 AMZ2 ASB5	1.58e-04	284	98	6	29459677
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	BCAS3 TBC1D5 CARMIL1 ZNF629 GRB10 SIK1 TSC2 FRYL MELK CRYBG3	1.61e-04	861	98	10	36931259
Pubmed	Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis.	NLRP3 CIITA	1.64e-04	7	98	2	17620097
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR3	1.64e-04	7	98	2	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR3	1.64e-04	7	98	2	20962236
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	CAD NOL6 AGPS DHX30 FANCD2 INTS11 ELP2 DNAH5 MOV10	1.72e-04	704	98	9	29955894
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR3	2.18e-04	8	98	2	19033399
Pubmed	Mapping genetic modulators of amyloid plaque deposition in TgCRND8 transgenic mice.	HSPG2 NLRP3	2.18e-04	8	98	2	16785251
Pubmed	Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.	RYR1 RYR3	2.18e-04	8	98	2	21441923
Pubmed	ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.	RYR1 RYR3	2.18e-04	8	98	2	30563862
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR3	2.18e-04	8	98	2	11784029
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	CAD NOL6 NUP43 CHD8 AGPS DHX30 MOV10	2.54e-04	440	98	7	34244565
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	GALNT14 TRAF3 CARMIL1 NEU3 IL1RL2 NLRP3	2.66e-04	313	98	6	20800603
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR3	3.13e-05	3	59	2	287
GeneFamily	NLR family	NLRP3 CIITA NLRC5	7.21e-05	25	59	3	666
GeneFamily	UPF1 like RNA helicases	ZGRF1 MOV10	5.65e-04	11	59	2	1169
GeneFamily	WD repeat domain containing	FBXW10B BCAS3 NUP43 EML3 ELP2	1.63e-03	262	59	5	362
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	TSC2 RYR1 SLC9A1 PPP1R16A	2.88e-03	181	59	4	694
GeneFamily	Immunoglobulin like domain containing	NPHS1 HSPG2 IL1RL2 AMIGO3	3.62e-03	193	59	4	594
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Striatum / BrainAtlas - Mouse McCarroll V32	GALNT14 CRACR2A DENND2D ADAMTS5 ADCY8 TH	5.02e-07	133	98	6	d5326a6ccada5ae6d3e8f7d4a858c90050e23c5b
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular\|TCGA-Stomach / Sample_Type by Project: Shred V9	FBXW10B CAD ATR ZGRF1 NOL6 FANCD2	6.23e-07	138	98	6	93497c0a5d5e54006653b2dedc7a7041e1a613e6
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ATP23 TTC21A GRB10 SIK1 TOX2 MOV10	1.28e-06	156	98	6	ff39712c7a2dc1b85c598d5105789aa291dea726
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-14\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	USP30 BICRA TTC21A AMZ2 CDYL2 TOX2	2.49e-06	175	98	6	87e557f7508c88b2087db5d57e77d5e2c92ca083
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR3	2.94e-05	3	93	2	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR3	2.94e-05	3	93	2	DOID:8545 (implicated_via_orthology)
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	TRAF3 GGNBP2 ASPHD1 SIM1 EML3 ADCY8 PDZRN4	1.57e-04	364	93	7	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	eosinophil count	CUL2 TRAF3 ZFP90 ATR TBC1D5 GRB10 IL1RL2 ITPKA CIITA CDYL2 NLRC5 ZNF319 TOX2	7.81e-04	1488	93	13	EFO_0004842
Disease	Kartagener syndrome (implicated_via_orthology)	DNAH5 FOXJ1	8.72e-04	14	93	2	DOID:0050144 (implicated_via_orthology)
Disease	body fat percentage	TRAF3 GGNBP2 ASPHD1 SIM1 EML3 ADCY8 PDZRN4	9.03e-04	488	93	7	EFO_0007800
Disease	HIV viral set point measurement	GALNT14 ZFP90 DEPTOR	1.05e-03	63	93	3	EFO_0006319
Disease	alkaline phosphatase measurement	HSPG2 CARMIL1 TSC2 FHIP2A NLRP3 GPR180 SCUBE3 CDYL2 CLUH PDZRN4	1.36e-03	1015	93	10	EFO_0004533
Disease	Tourette syndrome, schizophrenia	GGNBP2 TBC1D5	1.45e-03	18	93	2	EFO_0004895, MONDO_0005090
Disease	primary ciliary dyskinesia (implicated_via_orthology)	DNAH5 FOXJ1	1.62e-03	19	93	2	DOID:9562 (implicated_via_orthology)
Disease	comparative body size at age 10, self-reported	TRAF3 GGNBP2 SIM1 ADCY8 SCUBE3 MOV10	2.16e-03	420	93	6	EFO_0009819
Disease	aspartate aminotransferase measurement	ANKRD31 TBC1D5 CARMIL1 DENND2D NLRP3 MROH6 NLRC5 CCDC97 MOV10	2.21e-03	904	93	9	EFO_0004736
Disease	West Syndrome	SIK1 TSC2	2.59e-03	24	93	2	C0037769
Disease	airway responsiveness measurement	BCAS3 SCUBE3	2.59e-03	24	93	2	EFO_0006897
Disease	body fat percentage, coronary artery disease	DYNC2H1 BCAS3	2.59e-03	24	93	2	EFO_0001645, EFO_0007800
Disease	Brain Diseases	TSC2 TH	2.81e-03	25	93	2	C0006111
Disease	eye color	CARMIL1 SIK1 ADCY8	2.92e-03	90	93	3	EFO_0003949
Disease	age of onset of childhood onset asthma	TRAF3 ITPKA SCUBE3	3.11e-03	92	93	3	OBA_2001015
Disease	platelet crit	ANKRD31 USP30 ZFP90 DEPTOR BCAS3 TBC1D5 CARMIL1 NLRP3 MOV10	3.12e-03	952	93	9	EFO_0007985

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELFARFDRLAHEHHC	ADCY8	441	P40145
EFREACHIIPHDFHL	CHD8	1111	Q9HCK8
LFALEHCEGRELHLE	CRYBG3	2756	Q68DQ2
LLLISHFHLDHCGAL	CPSF3	66	Q9UKF6
LLELLHCAHEAEEAG	CIITA	806	P33076
AAILFTREDLCGHHS	ADAMTS5	361	Q9UNA0
HPLEHCEDTRLHDAA	ASB1	31	Q9Y576
FLDCLLHSLRELHTG	CMTR2	626	Q8IYT2
RLEGQCTALHHDKHE	CRACR2A	286	Q9BSW2
TLTHEIGHIFGLRHC	AMZ2	251	Q86W34
VHLDEHAFHGLRALS	AMIGO3	146	Q86WK7
LHRHRHHESEDECAL	DHX30	636	Q7L2E3
CAVHHLYTLHRGETE	BCAS3	391	Q9H6U6
FEGDHQLLCDIRHHG	NUP43	61	Q8NFH3
DSFTTGHLDHLLHCH	RAB5IF	121	Q9BUV8
RGCGHSVRLHELEAH	PDZRN4	86	Q6ZMN7
VFHDLNLTAHGISHC	HSPG2	3831	P98160
HGSHDLIHRLFVCIS	ZFYVE28	721	Q9HCC9
HLDDDCVTELSVHHR	MELK	281	Q14680
SLTECAHVRLHIAGH	FBXW10B	701	O95170
AALHDDADLVHHCIK	ANKRD31	496	Q8N7Z5
RVVTHELIHAFDHCR	ATP23	121	Q9Y6H3
RGEFHLHIEACDLSD	NPHS1	91	O60500
ERHIHVCCETDFIAH	GGNBP2	256	Q9H3C7
LDCVIISHFHLDHCG	INTS11	61	Q5TA45
AEGHCLLVDDSFLHT	ASPHD1	336	Q5U4P2
VEHYHLHLSSCHECL	HLCS	96	P50747
DHFHPCAALTTDHIE	DDX60	1001	Q8IY21
REEHLACFGHVRGDH	CCDC97	116	Q96F63
HLIGHCDHLSDEISI	FHIP2B	436	Q86V87
LPRCGHHEVDHFLRE	OR2W3	166	Q7Z3T1
HLLLHAIFIGFDHCH	FRYL	1621	O94915
HLLALHADIPETCVH	NOL6	621	Q9H6R4
VAHADHHLRGLFADL	MROH6	351	A6NGR9
RIGHFEFHGDHALLC	GPR180	41	Q86V85
EAVALRLAHCDLGAH	NLRC5	1436	Q86WI3
RLAHCDLGAHHSLLV	NLRC5	1441	Q86WI3
SGLGHCHHLEELDLS	NLRC5	1516	Q86WI3
IGSSLLFVHDHCHRA	ITPKA	396	P23677
GSHIEHIASHLCLDT	GALNT14	506	Q96FL9
LHLGKDDSLTCHLHF	IL1RL2	136	Q9HB29
DVLCLVHHHRDPSAV	ITPRIPL1	281	Q6GPH6
LSHLHGCRDHDEFII	DYNC2H1	2176	Q8NCM8
LHHLCKHLDFREDET	ATR	786	Q13535
KRTDLCDHALHISHD	CNPY2	166	Q9Y2B0
KLADRGIIHHVCDEH	DEPTOR	91	Q8TB45
VADHLQFLHAECHNI	CUL2	271	Q13617
DHISHCLLSAQFHRE	DDX12P	931	Q92771
HVDVDLTIHGRHIDC	FOXJ1	341	Q92949
LDHVTPLHEACLGDH	ASB5	101	Q8WWX0
LVEHHPHLGLERCLE	GRB10	211	Q13322
DEILDALSHCHHKLA	CARMIL1	851	Q5VZK9
FHLSEIRSLHVLEGC	CRYGC	116	P07315
HAHEGSIFALCLRRD	EML3	511	Q32P44
DRAHQHLVDFDCHLD	EMC9	166	Q9Y3B6
HFASCGEDHTVKIHR	ELP2	806	Q6IA86
PLRHRLIEHCDHISD	FHIP2A	451	Q5W0V3
PHLTHLDLRHCEVEL	CHADL	86	Q6NUI6
EACFLEHLHKHQGSV	BICRA	1081	Q9NZM4
EHRAHAIILGHCFFA	SLC22A14	266	Q9Y267
REGAEGLHCSEHLLL	SLC12A8	421	A0AV02
FHLAHDGHNCLDVDE	SCUBE3	101	Q8IX30
GHVLRLFHGHMDECL	RYR1	216	P21817
LEDAHRDANLHHVAC	C1orf50	96	Q9BV19
HFDSDFSHRLHLCDI	DIPK1C	266	Q0P6D2
HLEHVDFSSLLHCLS	DENND2D	226	Q9H6A0
TIHVHQRDIFDDLCH	DNAH5	1891	Q8TE73
FQLDTRLLHHLCGHS	FANCD2	1331	Q9BXW9
RDLHPDKVCTHHEFE	PRDM2	1211	Q13029
ENCHRVESLSLGFLH	NLRP3	671	Q96P20
DRHCVTFVLHEEDHT	POLR1D	36	P0DPB6
LHHRALDAEEEACLH	TIMM10B	36	Q9Y5J6
HVAGDRCIHEDLLGL	TRMT2A	386	Q8IZ69
VVHHHGLFQDRTCEI	STK40	106	Q8N2I9
IDHFTHIFIDEAGHC	MOV10	636	Q9HCE1
DHDRLHTLVTEHCFP	MRPL45	156	Q9BRJ2
LHAAATCGHLHLVEL	PPP1R16A	141	Q96I34
GCDTFHLRCAHHLLL	SIM1	271	P81133
AVEYCHDHHIVHRDL	SIK1B	136	A0A0B4J2F2
AVEYCHDHHIVHRDL	SIK1	136	P57059
DRVFRAHGHCLHEIF	AGPS	181	O00116
AHGHCLHEIFLLREG	AGPS	186	O00116
PEHHLLHCEEFIDEF	CDYL2	41	Q8N8U2
RTCFSLHLDGNVLDH	CLUH	86	O75153
LFTHREILSHLQGDC	NEU3	401	Q9UQ49
HLVISHLDLHICDDI	UHRF1BP1L	321	A0JNW5
GHLLVHLKNDCHFEE	TRAF3	131	Q13114
HEFLIAALDVLHRHC	USP27X	166	A6NNY8
GHVVRLFHGHDECLT	RYR3	221	Q15413
LFLNHSERLCHGEDR	TEX43	81	Q6ZNM6
FLDHLLTGIEDICGH	SLC9A1	526	P19634
LCHILEGHLEEAEYR	TTC21A	376	Q8NDW8
CEVAPHHLFLSHDDL	CAD	1636	P27708
HHLFLSHDDLERLGP	CAD	1641	P27708
SGEHHLFRCNVCELH	ZNF319	281	Q9P2F9
AHLEFHLCHHLDQLG	VPS13B	2486	Q7Z7G8
LCHLLSAVDFHHPDI	ZGRF1	1971	Q86YA3
LLHLGDHEASYHSLC	TOX2	91	Q96NM4
LDHCLHHFISSESVR	USP30	266	Q70CQ3
VLHCDHQAFLHASES	TBC1D5	216	Q92609
HCGESFLDRSVLLQH	ZNF629	666	Q9UEG4
THLDFHLEFHGDRII	TM9SF1	161	O15321
LLVDLAEGCHTHHFN	TSC2	511	P49815
AEGCHTHHFNSLLDI	TSC2	516	P49815
DVSEVSHCTHDLLHA	ZFP90	101	Q8TF47
SHCTHDLLHATLEDS	ZFP90	106	Q8TF47
THACGEHLEAFALLE	TH	276	P07101