Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnuclear receptor activity

NR2C2 NR2F6 NR2F1 NR2F2

5.20e-0560684GO:0004879
GeneOntologyMolecularFunctionligand-activated transcription factor activity

NR2C2 NR2F6 NR2F1 NR2F2

5.55e-0561684GO:0098531
GeneOntologyMolecularFunctionreceptor signaling protein tyrosine kinase activator activity

LTK ALK

1.14e-045682GO:0030298
GeneOntologyMolecularFunctionzinc ion binding

ZFAND1 NR2C2 NR2F6 TRIM75 RCHY1 TRIM71 TNKS APOBEC3C NR2F1 NR2F2 TRIM51G

1.96e-048916811GO:0008270
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

VPS11 TRIM75 RCHY1 TRIM71 ZNF598 LNX1 RNF43 TRIM51G

1.99e-04473688GO:0004842
GeneOntologyMolecularFunctionubiquitin protein ligase activity

VPS11 TRIM75 RCHY1 TRIM71 ZNF598 RNF43 TRIM51G

2.69e-04372687GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

VPS11 TRIM75 RCHY1 TRIM71 ZNF598 LNX1 RNF43 TRIM51G

3.39e-04512688GO:0019787
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

VPS11 TRIM75 RCHY1 TRIM71 ZNF598 RNF43 TRIM51G

4.04e-04398687GO:0061659
GeneOntologyMolecularFunctionaminoacyltransferase activity

VPS11 TRIM75 RCHY1 TRIM71 ZNF598 LNX1 RNF43 TRIM51G

4.37e-04532688GO:0016755
GeneOntologyMolecularFunctiontransition metal ion binding

ZFAND1 NR2C2 NR2F6 TRIM75 RCHY1 TRIM71 TNKS APOBEC3C NR2F1 NR2F2 TRIM51G

2.14e-0311896811GO:0046914
GeneOntologyBiologicalProcessprotein modification by small protein conjugation or removal

USP34 VPS11 SDE2 TRIM75 RCHY1 SMC6 TRIM71 TNKS USP9Y ZNF598 LNX1 RNF43 TRIM51G

1.84e-0510096713GO:0070647
GeneOntologyBiologicalProcesspost-translational protein modification

USP34 VPS11 SDE2 TRIM75 RCHY1 SMC6 TRIM71 TNKS USP9Y ZNF598 LNX1 RNF43 TRIM51G

3.54e-0510746713GO:0043687
DomainCOUP_TF

NR2F6 NR2F1 NR2F2

4.19e-075663IPR003068
Domainzf-C4

NR2C2 NR2F6 NR2F1 NR2F2

2.08e-0546664PF00105
DomainZnf_hrmn_rcpt

NR2C2 NR2F6 NR2F1 NR2F2

2.08e-0546664IPR001628
DomainNuclear_hrmn_rcpt

NR2C2 NR2F6 NR2F1 NR2F2

2.08e-0546664IPR001723
DomainNUCLEAR_REC_DBD_2

NR2C2 NR2F6 NR2F1 NR2F2

2.08e-0546664PS51030
DomainNUCLEAR_REC_DBD_1

NR2C2 NR2F6 NR2F1 NR2F2

2.08e-0546664PS00031
DomainZnF_C4

NR2C2 NR2F6 NR2F1 NR2F2

2.08e-0546664SM00399
Domain-

NR2C2 NR2F6 NR2F1 NR2F2

2.26e-05476641.10.565.10
DomainHOLI

NR2C2 NR2F6 NR2F1 NR2F2

2.46e-0548664SM00430
DomainNucl_hrmn_rcpt_lig-bd

NR2C2 NR2F6 NR2F1 NR2F2

2.46e-0548664IPR000536
DomainHormone_recep

NR2C2 NR2F6 NR2F1 NR2F2

2.46e-0548664PF00104
Domain-

NR2C2 NR2F6 NR2F1 NR2F2

4.88e-05576643.30.50.10
DomainZnf_NHR/GATA

NR2C2 NR2F6 NR2F1 NR2F2

5.23e-0558664IPR013088
Domain-

VPS11 RCHY1 SYTL5 MLLT6 TRIM71 ZNF598 LNX1 RNF43

1.78e-044496683.30.40.10
DomainZnf_RING/FYVE/PHD

VPS11 RCHY1 SYTL5 MLLT6 TRIM71 ZNF598 LNX1 RNF43

2.06e-04459668IPR013083
DomainPH_dom-spectrin-type

SPTBN4 ARHGAP25

4.36e-049662IPR001605
DomainZF_RING_1

VPS11 RCHY1 TRIM71 ZNF598 LNX1 RNF43

5.64e-04291666PS00518
DomainZF_RING_2

VPS11 RCHY1 TRIM71 ZNF598 LNX1 RNF43

6.38e-04298666PS50089
DomainTyr_kinase_rcpt_2_CS

LTK ALK

6.63e-0411662IPR002011
DomainRING

VPS11 RCHY1 TRIM71 ZNF598 LNX1 RNF43

7.21e-04305666SM00184
DomainRECEPTOR_TYR_KIN_II

LTK ALK

7.93e-0412662PS00239
DomainZnf_RING

VPS11 RCHY1 TRIM71 ZNF598 LNX1 RNF43

1.02e-03326666IPR001841
DomainARM-type_fold

USP34 VPS11 USP9Y ARMC2 NCAPG2 ARMC6

1.24e-03339666IPR016024
DomainEGF_1

ADAM21 NID1 VWCE ITGB8 NOTCH1

2.07e-03255665PS00022
DomainEGF-like_CS

ADAM21 NID1 VWCE ITGB8 NOTCH1

2.29e-03261665IPR013032
DomainEGF_2

ADAM21 NID1 VWCE ITGB8 NOTCH1

2.45e-03265665PS01186
DomainSpectrin

SPTBN4 SYNE3

2.97e-0323662PF00435
DomainEGF_CA

NID1 VWCE NOTCH1

3.50e-0386663PF07645
DomainSpectrin_repeat

SPTBN4 SYNE3

4.70e-0329662IPR002017
DomainEGF_Ca-bd_CS

NID1 VWCE NOTCH1

4.90e-0397663IPR018097
DomainEGF_CA

NID1 VWCE NOTCH1

5.19e-0399663PS01187
DomainASX_HYDROXYL

NID1 VWCE NOTCH1

5.34e-03100663PS00010
DomainSpectrin/alpha-actinin

SPTBN4 SYNE3

5.70e-0332662IPR018159
DomainSPEC

SPTBN4 SYNE3

5.70e-0332662SM00150
DomainZINC_FINGER_C2H2_2

ZC3H7A ZNF142 ZNF775 ZNF337 ZKSCAN7 ZNF470 ZNF761 ZNF598

5.81e-03775668PS50157
DomainZINC_FINGER_C2H2_1

ZC3H7A ZNF142 ZNF775 ZNF337 ZKSCAN7 ZNF470 ZNF761 ZNF598

5.90e-03777668PS00028
DomainEGF-type_Asp/Asn_hydroxyl_site

NID1 VWCE NOTCH1

6.27e-03106663IPR000152
DomainZnf_C2H2-like

ZC3H7A ZNF142 ZNF775 ZNF337 ZKSCAN7 ZNF470 ZNF761 ZNF598

6.79e-03796668IPR015880
PathwayWP_NUCLEAR_RECEPTORS

NR2C2 NR2F6 NR2F1 NR2F2

8.72e-0638494M39657
PathwayWP_NUCLEAR_RECEPTORS

NR2C2 NR2F6 NR2F1 NR2F2

8.72e-0638494MM15865
Pubmed

Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor.

NR2C2 NR2F6 NR2F1

7.47e-09369310644740
Pubmed

The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.

NR2F6 NR2F1 NR2F2

7.47e-09369318701084
Pubmed

Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.

NR2F6 NR2F1 NR2F2

1.49e-0766937947324
Pubmed

COUP-TFI and -TFII nuclear receptors are expressed in amacrine cells and play roles in regulating the differentiation of retinal progenitor cells.

NR2F1 NR2F2

3.88e-06269219766631
Pubmed

Novel NR2F1 variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype-phenotype correlation, and phenotypic expansion of the Bosch-Boonstra-Schaaf optic atrophy syndrome.

NR2F1 NR2F2

3.88e-06269228963436
Pubmed

An evolutionary conserved COUP-TF binding element in a neural-specific gene and COUP-TF expression patterns support a major role for COUP-TF in neural development.

NR2F1 NR2F2

3.88e-0626927708064
Pubmed

Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis.

NR2F1 NR2F2

3.88e-0626927626501
Pubmed

Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon.

NR2F1 NR2F2

3.88e-0626928183930
Pubmed

Localization of transcripts of the related nuclear orphan receptors COUP-TF I and ARP-1 in the adult mouse brain.

NR2F1 NR2F2

3.88e-0626927609634
Pubmed

Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.

NR2F6 NR2F1

3.88e-0626922905047
Pubmed

Dynamic expression of COUP-TFI and COUP-TFII during development and functional maturation of the mouse inner ear.

NR2F1 NR2F2

3.88e-06269215907456
Pubmed

Requirement for COUP-TFI and II in the temporal specification of neural stem cells in CNS development.

NR2F1 NR2F2

3.88e-06269219160499
Pubmed

All-trans retinoic acid affects the expression of orphan receptors COUP-TF I and COUP-TF II in the developing neural tube.

NR2F1 NR2F2

3.88e-0626928804707
Pubmed

Downregulation of Notch signaling by gamma-secretase inhibition can abrogate chemotherapy-induced apoptosis in T-ALL cell lines.

BACE1 NOTCH1

3.88e-06269219057901
Pubmed

The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon.

NR2F1 NR2F2

3.88e-06269228922831
Pubmed

Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis.

LTK ALK

3.88e-06269222079349
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

USP34 NR2F6 SYNE3 SZT2 MLLT6 LTK TOP3B RNF43 NR2F2 NOTCH1 ITPR3

1.07e-051105691135748872
Pubmed

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

NR2F6 NR2F1 NR2F2

1.12e-052269323975195
Pubmed

Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.

BACE1 NOTCH1

1.16e-05369223713656
Pubmed

Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway.

NR2C2 NR2F2

1.16e-05369231633027
Pubmed

An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells.

NR2F2 NOTCH1

1.16e-05369220351309
Pubmed

Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) modulates expression of the Purkinje cell protein-2 gene. A potential role for COUP-TF in repressing premature thyroid hormone action in the developing brain.

NR2F1 NR2F2

1.16e-0536929632703
Pubmed

Transcription factors COUP-TFI and COUP-TFII are required for the production of granule cells in the mouse olfactory bulb.

NR2F1 NR2F2

1.16e-05369225922524
Pubmed

Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).

LTK ALK

1.16e-05369230061385
Pubmed

Chicken ovalbumin upstream promoter-transcription factor members repress retinoic acid-induced Cdx1 expression.

NR2F1 NR2F2

1.16e-05369215677473
Pubmed

Regulation of renin expression by the orphan nuclear receptors Nr2f2 and Nr2f6.

NR2F6 NR2F2

1.16e-05369222278040
Pubmed

Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter.

NR2F6 NR2F2

1.16e-05369211382775
Pubmed

Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.

NR2F1 NR2F2 NOTCH1

1.88e-052669312397111
Pubmed

Regulation of vascular endothelial growth factor D by orphan receptors hepatocyte nuclear factor-4 alpha and chicken ovalbumin upstream promoter transcription factors 1 and 2.

NR2F1 NR2F2

2.32e-05469218199540
Pubmed

Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.

LTK ALK

2.32e-05469226630010
Pubmed

Structural basis of cytokine-mediated activation of ALK family receptors.

LTK ALK

2.32e-05469234646012
Pubmed

The COUP-TF nuclear receptors regulate cell migration in the mammalian basal forebrain.

NR2F1 NR2F2

2.32e-05469215548577
Pubmed

FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.

LTK ALK

2.32e-05469226418745
Pubmed

Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors.

NR2F1 NR2F2

2.32e-05469210744719
Pubmed

A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program.

NR2F1 NR2F2

3.86e-0556929177236
Pubmed

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

BACE1 NOTCH1

3.86e-05569212354787
Pubmed

Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2.

NR2F6 NR2F2

3.86e-05569210318855
Pubmed

Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation.

NR2C2 NOTCH1

5.79e-05669229228365
Pubmed

Abnormal arterial-venous fusions and fate specification in mouse embryos lacking blood flow.

NR2F2 NOTCH1

5.79e-05669228931948
Pubmed

Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7.

VPS11 TNKS

5.79e-05669211382755
Pubmed

MTG8 interacts with LHX6 to specify cortical interneuron subtype identity.

NR2F1 NR2F2 NOTCH1

6.49e-053969336064547
Pubmed

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).

TNKS NOTCH1

8.09e-05769219245366
Pubmed

CoupTFI interacts with retinoic acid signaling during cortical development.

NR2F1 NR2F2

8.09e-05769223472160
Pubmed

The orphan nuclear receptors COUP-TFI and COUP-TFII regulate expression of the gonadotropin LHβ gene.

NR2F1 NR2F2

8.09e-05769220797425
Pubmed

Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.

LTK ALK

8.09e-05769219815557
Pubmed

A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation.

NID1 NOTCH1

1.08e-04869227354375
Pubmed

Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals.

NR2F2 NOTCH1

1.08e-04869224550118
Pubmed

Discovery of genes required for body axis and limb formation by global identification of retinoic acid-regulated epigenetic marks.

NR2F1 NR2F2

1.08e-04869232421711
Pubmed

Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.

NID1 NR2F2 NOTCH1

1.37e-045069324449835
Pubmed

Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes.

NR2F1 NR2F2

1.38e-0496928530078
Pubmed

Zic4-Lineage Cells Increase Their Contribution to Visual Thalamic Nuclei during Murine Embryogenesis If They Are Homozygous or Heterozygous for Loss of Pax6 Function.

NR2F1 NR2F2

1.38e-04969230406191
Pubmed

Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.

USP34 USP9Y

1.38e-04969237149635
Pubmed

A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells.

NR2F1 NR2F2

1.38e-0496927823919
Pubmed

Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.

NR2C2 NR2F6 NR2F1 NR2F2

1.46e-0413369415604093
Pubmed

LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.

LTK ALK

1.73e-041069237291945
Pubmed

COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis.

NR2F1 NR2F2

2.11e-041169220147377
Pubmed

Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.

NR2F2 NOTCH1

2.11e-041169215875024
Pubmed

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

USP34 VPS11 RPGRIP1L SZT2

2.14e-0414769429576527
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

SPTBN4 USP34 PLA2G3 TNKS TM2D3 ANKRD36 USP9Y LNX1 ITGB8 SEPTIN2

2.14e-041285691035914814
Pubmed

Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases.

NR2F1 NR2F2

2.53e-041269215140878
Pubmed

The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors.

NR2F1 NR2F2

2.53e-041269219812316
Pubmed

Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).

NR2F1 NR2F2

2.53e-041269216219912
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

NR2C2 NR2F6 ZNF598 TOP3B NR2F1 NR2F2 NOTCH1 ARMC6

2.92e-0485769825609649
Pubmed

Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium.

DNAH6 NOTCH1

2.98e-041369235942101
Pubmed

Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2.

NR2F2 NOTCH1

2.98e-041369237317851
Pubmed

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.

NR2F1 NR2F2

2.98e-041369235613264
Pubmed

Gradient COUP-TFI Expression Is Required for Functional Organization of the Hippocampal Septo-Temporal Longitudinal Axis.

NR2F1 NR2F2

3.48e-041469226813976
Pubmed

The expression profiles of nuclear receptors in the developing and adult kidney.

NR2F1 NR2F2

3.48e-041469216973757
Pubmed

Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.

NR2F2 NOTCH1

4.01e-041569225072663
Pubmed

Stepwise arteriovenous fate acquisition during mammalian vasculogenesis.

NR2F2 NOTCH1

4.01e-041569221793101
Pubmed

Endocardial cushion morphogenesis and coronary vessel development require chicken ovalbumin upstream promoter-transcription factor II.

NR2F2 NOTCH1

4.01e-041569222962329
Pubmed

COUP-TFI controls Notch regulation of hair cell and support cell differentiation.

NR2F1 NOTCH1

4.01e-041569216914494
Pubmed

Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium.

NR2F1 NR2F2

4.57e-041669219596317
Pubmed

Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression.

NID1 NOTCH1

4.57e-041669217021047
Pubmed

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.

ZNF142 LTK VWCE NOTCH1

4.61e-0418069424104479
Pubmed

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.

NR2F6 NR2F1 NR2F2

4.92e-047769319505873
Pubmed

The expression pattern of nuclear receptors during cerebellar development.

NR2F1 NR2F2

5.18e-041769217205580
Pubmed

The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development.

NR2F2 NOTCH1

5.81e-041869216678147
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

NR2F2 NOTCH1

5.81e-041869218093989
Pubmed

Chromosomal mapping of Adam9, Adam15 and Adam21.

ADAM21 TNKS

5.81e-041869210842103
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

USP34 MTMR12 NID1 TNKS ZNF598 ECM1 NCAPG2 ITPR3

6.79e-0497469828675297
Pubmed

Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons.

NR2F1 NR2F2

7.95e-042169228694260
Pubmed

Developmental diversification of cortical inhibitory interneurons.

NR2F1 NR2F2 NOTCH1

8.01e-049169329513653
Pubmed

A multipotent progenitor domain guides pancreatic organogenesis.

NR2C2 NR2F6 RNF43

8.01e-049169317609113
Pubmed

Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid.

NR2F1 NR2F2

8.73e-042269210753524
Pubmed

FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis.

NR2F1 NOTCH1

8.73e-042269222031906
Pubmed

Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung.

NR2F2 NOTCH1

9.55e-042369233830085
Pubmed

Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice.

NID1 NOTCH1

9.55e-042369223386589
Pubmed

The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk.

NR2F1 NR2F2

1.04e-032469228729440
Pubmed

Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis.

NR2F2 NOTCH1

1.04e-032469225382630
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

ALK NOTCH1 ITPR3

1.08e-0310169323382219
Pubmed

Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII.

NR2F1 NR2F2

1.13e-032569228706241
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

ZC3H7A ZNF598 TOP3B

1.28e-0310769330995489
Pubmed

COUP-TFII controls amygdala patterning by regulating neuropilin expression.

NR2F1 NR2F2

1.42e-032869222492355
Pubmed

FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac.

NR2F2 NOTCH1

1.42e-032869235297995
Pubmed

Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.

NR2F1 NR2F2

1.42e-032869229365100
Pubmed

Canonical Wnt/β-catenin signalling is essential for optic cup formation.

NR2F1 NR2F2

1.52e-032969224324671
Pubmed

Impaired Interneuron Development after Foxg1 Disruption.

NR2F2 NOTCH1

1.52e-032969226620267
Pubmed

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.

NR2F1 NOTCH1

1.52e-032969217928865
Pubmed

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.

ZC3H7A VPS11 RPGRIP1L SEPTIN2

1.59e-0325169429778605
InteractionGGA3 interactions

VPS11 BACE1 LTK TOP3B ALK RNF43

2.92e-06120676int:GGA3
InteractionHYOU1 interactions

NR2C2 SYNE3 ADAM21 BACE1 LTK TOP3B ALK RNF43

9.99e-06317678int:HYOU1
InteractionNOTCH2 interactions

NR2C2 ZNF142 ZNF775 SYNE3 ZNF761 LTK ZNF598 TOP3B NOTCH1

1.06e-05423679int:NOTCH2
Cytoband19q13.13

SPTBN4 ARHGEF1

2.31e-041569219q13.13
Cytoband2p15

USP34 WDPCP

1.01e-03316922p15
Cytoband2p13.3

FAM136A ARHGAP25

1.36e-03366922p13.3
CytobandEnsembl 112 genes in cytogenetic band chr2p15

USP34 WDPCP

2.02e-0344692chr2p15
GeneFamilyNuclear hormone receptors

NR2C2 NR2F6 NR2F1 NR2F2

1.26e-054953471
GeneFamilyRing finger proteins

VPS11 TRIM75 RCHY1 TRIM71 LNX1 RNF43

1.48e-0427553658
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM75 TRIM71 TRIM51G

2.72e-039553359
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF142 ZNF775 ZNF337 ZKSCAN7 ZNF470 ZNF761 ZNF598

4.76e-0371853728
GeneFamilyReceptor Tyrosine Kinases|CD molecules

LTK ALK

6.12e-0340532321
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

ARMC2 ARMC6

7.05e-0343532409
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP25 ARHGAP27

9.44e-0350532721
GeneFamilyUbiquitin specific peptidases

USP34 USP9Y

1.17e-0256532366
CoexpressionDESCARTES_ORGANOGENESIS_EPENDYMAL_CELL

KIF9 RPGRIP1L CROCC2 EFCAB12 ZKSCAN7 ARMC2 DNAH6

8.57e-06282687MM3642
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CTDSPL2 LNX1 ARMC2 HECA NR2F2

5.80e-0616569501c6355177d79b4523c8b20366e20b2b62c6d08d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYTL5 NID1 ALK ITGB8 NR2F2

6.52e-06169695f47c4fbdc2a38745ec1b35104b85121c1413875a
ToppCell343B-Fibroblasts-Fibroblast-B_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZNF142 ARHGAP25 TSTD2 DNAH6 RNF43

7.10e-06172695c6bc78fd63c9479a84ec0552b55c89750cad0fa5
ToppCell343B-Fibroblasts-Fibroblast-B_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ZNF142 ARHGAP25 TSTD2 DNAH6 RNF43

7.10e-06172695bfb87a281a9cf6ad45b310bf8104fc0ab382b549
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYTL5 NID1 ALK ITGB8 NR2F2

8.62e-061796950b6731d9554f8bed1899c165a50e6b329ea19a6d
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYTL5 NID1 ALK ITGB8 NR2F2

8.85e-06180695392bc71a69653ba12de31bed4e9357f181094641
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYTL5 NID1 ALK ITGB8 NR2F2

1.06e-05187695d2ffb2f34f07b0dd5d3cb3ee0275f46ebecf4146
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYTL5 NID1 ALK ITGB8 NR2F2

1.09e-05188695ee572246e0c2f41bdbc29a03edc67b831af95c09
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SPTBN4 VPS11 BORCS5 SMC6 ARHGAP25

1.15e-05190695ed100e271aac82806f59e0c613ccda63f59100c1
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPGRIP1L CROCC2 EFCAB12 ARMC2 DNAH6

1.37e-0519769574a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12|Neuronal / cells hierarchy compared to all cells using T-Statistic

SYTL5 NID1 ALK ITGB8 NR2F2

1.47e-05200695c74bc12e13d002dedaaf75a2244ec111e47524e1
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6-CDH12-L1-2|Neuronal / cells hierarchy compared to all cells using T-Statistic

SYTL5 NID1 ALK ITGB8 NR2F2

1.47e-05200695ead9eb579bb25fde05fc15602e3d05ab6617f7ac
ToppCellNeuronal-Inhibitory-iA-iA_1(SST_PAX6)-PAX6|Neuronal / cells hierarchy compared to all cells using T-Statistic

SYTL5 NID1 ALK ITGB8 NR2F2

1.47e-052006958a8f9d9e5ffab3f736c4bd0a5bb616d442d137d1
ToppCellE18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B|E18.5-samps / Age Group, Lineage, Cell class and subclass

SYNE3 MLLT6 ZNF598 ECM1

6.10e-05137694b553958e7e6dcd887d860e34d3983cbb85cefaa6
ToppCell390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|390C / Donor, Lineage, Cell class and subclass (all cells)

SPTBN4 ARHGEF1 LSP1 APOBEC3C

9.36e-05153694ce7a23c687e9e7d83d244046de19c854caded09b
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NID1 ALK NR2F1 NR2F2

1.03e-04157694bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR2F6 ZNF598 LNX1 RNF43

1.06e-0415869412661763d1c309106801cb710c04cd2b62d16cba
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR2F6 ZNF598 LNX1 RNF43

1.06e-04158694e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR2F6 ZNF598 LNX1 RNF43

1.06e-041586940792c39e6fc0745095af7812de2d50949540d60f
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-GABAergic_neurons|GW16 / Sample Type, Dataset, Time_group, and Cell type.

SYTL5 NR2F1 NR2F2 ITPR3

1.22e-041646944d7b2d0980fb4f47721fa2891151e2bd892ccb91
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)|Striatum / BrainAtlas - Mouse McCarroll V32

NR2C2 VPS11 ZNF598 HECA

1.37e-04169694c3bf0cb67f200d02d5a021754e9b2a68d23ea168
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)--|Striatum / BrainAtlas - Mouse McCarroll V32

NR2C2 VPS11 ZNF598 HECA

1.37e-041696945375eb52ebadccb7bfff997a11985f23e81014d6
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)-|Striatum / BrainAtlas - Mouse McCarroll V32

NR2C2 VPS11 ZNF598 HECA

1.37e-041696941c132d21255f5a5174ac38db4e91927f9093418e
ToppCellAdult-Mesenchymal-pericyte_cell-D231|Adult / Lineage, Cell type, age group and donor

NID1 ECM1 NR2F1 NR2F2

1.47e-04172694858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NR2F6 SYNE3 SZT2 HECA

1.50e-0417369420f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-A|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NR2C2 SYNE3 APOBEC3C HECA

1.50e-041736941bf9c91c1803a540b5e43bc4280aab4289341cee
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYTL5 ALK ITGB8 NR2F2

1.68e-0417869408b4a497aca0aeabf4f6a8a55c05b56417b69e78
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYTL5 ALK ITGB8 NR2F2

1.68e-04178694e86ed30652c2de70f16430f04b78789b87df4af2
ToppCellASK454-Endothelial-Lymphatic|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

NID1 NCAPG2 NR2F1 NR2F2

1.71e-04179694fd84a79f76a01c0377dff5b20016b004d369f96f
ToppCellnormal_Lung-Fibroblasts-Pericytes|normal_Lung / Location, Cell class and cell subclass

NID1 ECM1 NR2F1 NR2F2

1.79e-04181694f74941e49950027360d71ea3b205fc20c6929766
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYTL5 ALK ITGB8 NR2F2

1.79e-0418169403a303cd2f366f09c18b118bbba6f5e3f95ad56c
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYTL5 ALK ITGB8 NR2F2

1.79e-041816948fd64404e57c22c204d835fc5626f73554257b19
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Deuterosomal|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KIF9 CROCC2 EFCAB12 DNAH6

1.82e-04182694000eca5baa6eb2335a1e6d76a13fff5382b0e150
ToppCell10x3'2.3-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

NID1 ECM1 NR2F1 NR2F2

1.82e-04182694997d37ca2af661c92a56add888762724dfccc890
ToppCellCOPD-Stromal-Pericyte|COPD / Disease state, Lineage and Cell class

NID1 ECM1 NR2F1 NR2F2

1.90e-04184694a56264a22dfc2d3672b20134ab7c3c7c23da5ae1
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYTL5 ALK ITGB8 NR2F2

1.94e-0418569479cff4f3c6ae8e5ea60e8eae082b9275f2679ee9
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 LSP1 LTK NR2F1

1.98e-041866947278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NID1 ECM1 NR2F1 NR2F2

2.19e-041916941626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NID1 ECM1 NR2F1 NR2F2

2.19e-04191694716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-NK|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BORCS5 ZNF337 ZNF598 NCAPG2

2.24e-04192694930319cbd82b9e54864147ffcdc8bd0ea7b937be
ToppCell10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

BORCS5 ZNF337 ZNF598 NCAPG2

2.24e-04192694c7bcebcb88a25b2c97d798120efa9d5958e7f798
ToppCellNS-moderate-d_07-13-Lymphoid|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ARHGEF1 LSP1 ARHGAP25 APOBEC3C

2.24e-04192694bd4059bfc2159f5ed8bbb2a5408b56117ca6f8e1
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

EFCAB12 ARMC2 DNAH6 WDPCP

2.28e-04193694ea345d34440b25f65358a53dc72831998d1c3620
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ANKRD36 USP9Y ALK ITGB8

2.28e-041936949337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN4 NID1 ECM1 NR2F2

2.28e-041936942483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NID1 ECM1 NR2F1 NR2F2

2.33e-041946948f19e553f18c313c2a2ff9453884b9484b255d71
ToppCell10x5'v1-week_14-16-Endothelial-stroma-proliferating_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

NID1 ECM1 NR2F1 NR2F2

2.33e-041946948a4be91414a2e69dd410aa75791f16008204c9a1
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NID1 ECM1 NR2F1 NR2F2

2.33e-0419469467fbb81b7d20cb63be27b2a2beea5b5689f8e08c
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TNKS ITGB8 NR2F1 NR2F2

2.33e-041946948b81f039f5b25d35a4d5a41b27d4d9360ba22f15
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SMC6 NID1 NCAPG2 NR2F2

2.33e-04194694af4bbb2deb5a3913eb58990690fc3c62fbc3708c
ToppCell5'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NID1 ECM1 NR2F1 NR2F2

2.33e-04194694f95935153bd2c4c3c7b2b729da6f7e98b45fed79
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RPGRIP1L CROCC2 EFCAB12 DNAH6

2.33e-041946944a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ARHGEF1 LSP1 ARHGAP25 APOBEC3C

2.33e-04194694bf7bf75bbc2035be25d3605e6a1a59e6bc573be7
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

USP34 BORCS5 SMC6 ANKRD36

2.37e-04195694ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCellcellseq-Mesenchymal-Myocytic-Myocytic_1|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NID1 ECM1 NR2F1 NR2F2

2.42e-04196694c373465e34e2dd581247962d59e0477aae877079
ToppCell10x_3'_v2v3-Non-neoplastic-Vascular-Mural_cell-Pericyte-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NID1 ECM1 NR2F2 SEPTIN2

2.42e-0419669412d9028f90c057c6e5cff00301793fa550e86c5a
ToppCellcellseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NID1 ECM1 NR2F1 NR2F2

2.42e-041966948b5337ccf74de90e8b89a02ac00671af1de2cfff
ToppCell10x3'2.3-week_17-19-Endothelial-stroma-sinusoidal_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NID1 ECM1 NR2F1 NR2F2

2.47e-041976944e58bbf3ecb30b4c8199adcc04d2eb134d90de56
ToppCelldroplet-Bladder-BLADDER-1m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NID1 LSP1 ECM1 NR2F2

2.47e-041976941e24150c5146c93914aaaa981bd17589e8ed7cf9
ToppCelldistal-mesenchymal-Vascular_Smooth_Muscle-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.47e-04197694da653dc7d216e202f390e5ab0245f243e3ed213b
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-monocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GPR155 ITGB8 NR2F1 NR2F2

2.47e-04197694b2f4d7c301c0b24003374923b31d6d058e40b213
ToppCelldroplet-Bladder-BLADDER|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NID1 LSP1 ECM1 NR2F2

2.47e-041976945ae84f796005fa7b75d10b6464770da6cd5c8f53
ToppCellwk_20-22|World / Celltypes from embryonic and fetal-stage human lung

ARHGEF1 LSP1 ARHGAP25 ARHGAP27

2.52e-0419869456eb765773a1a27a44262a447df7cfae8a9db90d
ToppCellcellseq-Mesenchymal-Myocytic|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NID1 ECM1 NR2F1 NR2F2

2.56e-0419969420e62a7029fa0d214244cdf2a481fc5d78290438
ToppCelldistal-mesenchymal-Pericyte-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.56e-04199694e72ac7a00405cde06293d7adac7dc40eb0cf87ba
ToppCellTransverse-T_cell-Tfh|T_cell / Region, Cell class and subclass

ZNF775 ARHGAP27 NCAPG2 NOTCH1

2.56e-0419969433ffea12b8228e0b5bd8942531c3b21d24224725
ToppCelldistal-mesenchymal-Pericyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.56e-04199694000d9b5f5a48e56f0733390adb3d7270c49a4a1a
ToppCellmedial-mesenchymal-Pericyte-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694bbda454260016be92b539e220ecf7bcbbc6139e4
ToppCellmedial-2-mesenchymal|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694a9d8aa5bcf383d98a9e2eaf4b1f8466982d6b088
ToppCellproximal-3-mesenchymal-Pericyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-0420069498cbd0f4994e645f70c0bc5ebc1c3a3b28c6b67f
ToppCelldistal-3-mesenchymal-Pericyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694911db29f254bb697610e720ba78816e2c7f57933
ToppCelldistal-mesenchymal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694b54137a4545690f51e154bb05964eaa650c3ca8e
ToppCell10x5'v1-week_14-16-Endothelial-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

NID1 ECM1 NR2F1 NR2F2

2.61e-042006942488aa12970a43a5af352e2c36c73884d73a1cc5
ToppCellParenchymal-10x3prime_v2-Stromal-Pericyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694d70bad979299615fcba707ba21296020918705e6
ToppCell10x5'v1-week_14-16-Endothelial-stroma-tip_EC|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

NID1 ECM1 NR2F1 NR2F2

2.61e-0420069477ac1aa73c16a4f595ff01c6b4e171e0b8fed1e6
ToppCellmedial-mesenchymal-Pericyte|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694f36d7cb6345daccebf76997f998e35d959b59452
ToppCelldistal-2-mesenchymal|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-0420069465a50f03b0027ccefb51b8f77afa283d4a3b3567
ToppCelldistal-mesenchymal-Pericyte|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694fe31287cfb51d45643bdedbaa5efc03ed87263c6
ToppCellParenchymal-10x3prime_v2-Stromal-Pericyte-Muscle_pericyte_pulmonary|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NID1 ECM1 NR2F1 NR2F2

2.61e-0420069438c21ec379005f688df33aea65237a063c476c2e
ToppCellmedial-2-mesenchymal-Pericyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-042006949820fb4f6efcdfc6de937ef2302a98b48426baa3
ToppCellParenchymal-10x3prime_v2-Stromal|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694f6be0f24e607abb9007823a54fb0b24d04990a89
ToppCelldistal-mesenchymal-Pericyte-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694867935701fac71a3fe01578362da0676f959736c
ToppCellParenchymal-10x5prime-Stromal-Pericyte-Muscle_pericyte_pulmonary|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694f9bc22ff17bb1c751e6b05bca3f403836f33459a
ToppCellmedial-mesenchymal|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-042006944f19e1e40966e27779bf77e8c170ed3ecc24353e
ToppCelldistal-1-mesenchymal-Pericyte|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694ff205afda57b9267016f0c937445da1b0266af9b
ToppCell10x5'v1-week_14-16-Endothelial|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694e786544cf6f891550c4be55ebb4928c92297b504
ToppCellproximal-mesenchymal-Pericyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-0420069403119a979bc912a98e6fc87addcbc25d8ecf2fb0
ToppCellParenchymal-10x5prime-Stromal-Pericyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NID1 ECM1 NR2F1 NR2F2

2.61e-042006940a7640db28c708003d5da2d19eb651f6fedfd710
ToppCelldistal-2-mesenchymal-Pericyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-042006944ee0b2f56c2652435fa78bf6b3c90cea28df74e0
ToppCellproximal-mesenchymal-Pericyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NID1 ECM1 NR2F1 NR2F2

2.61e-04200694a81fde3d40b8efb3be535aeb2a44cfbdeb17bc8b
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_2|Thalamus / BrainAtlas - Mouse McCarroll V32

ANTXRL SYNE3 BACE1

2.80e-0482693c7455742835027e3c8c67ad6a241c432cf29cb57
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr|Thalamus / BrainAtlas - Mouse McCarroll V32

ANTXRL SYNE3 BACE1

2.80e-048269382be5116c32d080da1e0289c341e3afa899a0337
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocyte.Tnr.Pdgfa_(Pdgfa)|Thalamus / BrainAtlas - Mouse McCarroll V32

ANTXRL SYNE3 BACE1

2.80e-0482693b4ead9db9fe0b78ec9fa9505a699233d8bb9d6da
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Hpcal1-Tpbg_(Entorhinal_cortex)|Hippocampus / BrainAtlas - Mouse McCarroll V32

LSP1 ARHGAP25 SHCBP1L

3.01e-0484693171fc90fb0d430ebf0a040c54f083aebb0e2b390
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Nxph3-Excitatory_Neuron.Slc17a7.Nxph3-Hpcal1-Tpbg_(Entorhinal_cortex)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

LSP1 ARHGAP25 SHCBP1L

3.01e-0484693a087403869ee4275cb1fa4e9b0b16426dcf72a31
DrugCDRI-85/287

NR2C2 NR2F6 NR2F1 NR2F2

1.63e-0629684CID000159508
DrugDR-0

NR2C2 NR2F6 NR2F1 NR2F2

3.55e-0635684CID010062716
DrugImplanon

NR2C2 NR2F6 NR2F1 NR2F2

1.18e-0547684CID000040976
Drugsodium molybdate

NR2C2 NR2F6 NR2F1 NR2F2

2.55e-0557684CID000061424
DrugAC1Q6CTU

NR2C2 LSP1 ZKSCAN7 NR2F1 NR2F2

2.76e-05118685CID000021362
Diseaseneuroblastoma (implicated_via_orthology)

LTK ALK

4.91e-055662DOID:769 (implicated_via_orthology)
Diseaseattention deficit hyperactivity disorder, asthma

WDPCP ITPR3

2.19e-0410662EFO_0003888, MONDO_0004979
Diseasebasophil measurement

LSP1 HECA WDPCP

3.34e-0460663EFO_0803539
DiseaseEndometrioma

NR2C2 NR2F6 ITGB8 NR2F2

4.73e-04161664C0269102
DiseaseEndometriosis

NR2C2 NR2F6 ITGB8 NR2F2

4.73e-04161664C0014175
DiseaseMeckel-Gruber syndrome

RPGRIP1L WDPCP

5.08e-0415662C0265215
Diseasepulse pressure measurement, alcohol drinking

LSP1 TNKS LNX1

5.26e-0470663EFO_0004329, EFO_0005763
DiseaseMeckel syndrome type 1

RPGRIP1L WDPCP

7.37e-0418662C3714506
Diseasepulse pressure measurement, alcohol consumption measurement

LSP1 LNX1

1.11e-0322662EFO_0005763, EFO_0007878
DiseaseHeart valve disease

LSP1 NOTCH1

1.55e-0326662C0018824
DiseaseFEV/FEC ratio

USP34 BORCS5 CROCC2 LNX1 ARMC2 HECA ITGB8 NR2F2 SEPTIN2

1.59e-031228669EFO_0004713
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

NR2F6 NR2F1 NR2F2

1.70e-03105663DOID:9352 (implicated_via_orthology)
Diseasealkaline phosphatase measurement

USP34 KIF9 ZNF337 ARHGAP25 TNKS NOTCH1 ARMC6 SEPTIN2

1.87e-031015668EFO_0004533

Protein segments in the cluster

PeptideGeneStartEntry
RCLRCLRQQHDDFAD

BACE1

481

P56817
NRHGCRQAFHVTCAQ

MLLT6

141

P55198
AAECCREILHHVNQA

ARHGEF1

591

Q92888
NICLRHSQHSRECLA

ANTXRL

531

A6NF34
RHRLFREHCVCVQGN

CTDSPL2

371

Q05D32
RCNNHDQHCREIFGK

ADAM21

506

Q9UKJ8
DHDVCDFIVQNNVHR

ARMC2

706

Q8NEN0
CVRHACLKHEQNRQD

ARMC6

201

Q6NXE6
RNQVDSETHCHAERC

APOBEC3C

56

Q9NRW3
CRLNAARCDHDQSHS

ANKRD36

1606

A6QL64
QCHLVRCGNRHFDEH

EFCAB12

356

Q6NXP0
TCRSNRDCQIDQHHR

NR2F6

91

P10588
RDCQIDQHHRNQCQY

NR2F6

96

P10588
NQDCIINKHHRNRCQ

NR2C2

156

P49116
TCRANRNCPIDQHHR

NR2F1

121

P10589
RNCPIDQHHRNQCQY

NR2F1

126

P10589
CPIDQHHRNQCQYCR

NR2F2

121

P24468
CENHNRDLQNFLRCQ

ITPR3

1881

Q14573
QRVNDFHCECRAGHT

NOTCH1

1286

P46531
QEHLCDNCVRAHQRV

TRIM71

216

Q2Q1W2
ELHITIRCCNHLQSR

RPGRIP1L

791

Q68CZ1
IRCCNHLQSRASHLQ

RPGRIP1L

796

Q68CZ1
SHRNVVNCALCHRAL

HECA

391

Q9UBI9
GHCFLDRCNHLRQND

MTMR12

431

Q9C0I1
CQQFIHYHRDLCIRN

GPR155

751

Q7Z3F1
ENHFIHRDIAARNCL

LTK

636

P29376
ANNRHQCSVHAECRD

NID1

391

P14543
CTQVLQRCDLEHHFQ

LNX1

111

Q8TBB1
RAEIQYCQHLVDQCR

KIF9

681

Q9HAQ2
QRHYCSRNEIEHCLC

OR56B4

171

Q8NH76
IHIHRNCSCQCEDNR

ITGB8

461

P26012
ERHLAINCVHDRVVC

WDPCP

226

O95876
CHECQRVFHDRLINN

DNAH6

2326

Q9C0G6
DALQARLDQACHRIH

CROCC2

1256

H7BZ55
QLCLRYQDHLHQCAE

BORCS5

91

Q969J3
AVHEQCQHERDRQLQ

LSP1

31

P33241
LEREFQRCCRQGNNH

ECM1

341

Q16610
HQCIERCHVPLAQAQ

FAM136A

51

Q96C01
RCTVRDFIHRHCQDQ

SDE2

26

Q6IQ49
TQQEASRVCVHCHRN

SYTL5

56

Q8TDW5
NHCALLQEHAQRCYV

SZT2

1291

Q5T011
DRCRQSVQEHCTFSH

SYNE3

641

Q6ZMZ3
FQHLCRVIEHGEQNR

ARHGAP27

826

Q6ZUM4
RVISCLHEFHRNCVD

RNF43

286

Q68DV7
AILERNEIHHCNNLR

SHCBP1L

541

Q9BZQ2
CRSFRRHLDQCEHQI

PLA2G3

361

Q9NZ20
EENHFIHRDIAARNC

ALK

1241

Q9UM73
IHVIRHCLNACIQRA

NCAPG2

571

Q86XI2
CNVVAHCFENAHRVR

TOP3B

751

O95985
FNQKRNLACHRRCHT

ZNF761

251

Q86XN6
QKRDLHDQFQHQLRC

VPS11

876

Q9H270
ICRFLHEIQLNCAVN

ARHGAP25

291

P42331
RFCHRQKEVSEENHN

TNKS

1161

O95271
CRHQCQEGHFRSNTQ

TRIM75

56

A6NK02
LHGNRHSCVDVNECR

VWCE

211

Q96DN2
CERCFRHQVGLRIHQ

ZNF775

196

Q96BV0
AFRQRASLICHQRCH

ZNF470

601

Q6ECI4
LQAYCCHNHADERVL

SMC6

531

Q96SB8
CNRVNHVHGCLAELQ

SPTBN4

616

Q9H254
CCRQLFTDQTSIHRH

TSTD2

81

Q5T7W7
HRCIINNTHRLVELC

USP9Y

146

O00507
QHELFCCRLCLQHLQ

ZNF598

141

Q86UK7
FHGQCQLDLCRHEVR

ZC3H7A

626

Q8IWR0
LCLLCSNSQEHRNHR

TRIM51G

111

A0A3B3IT33
AFCSNRNLIDHQRIH

ZKSCAN7

531

Q9P0L1
LNRRHIIDNRVHCCF

SEPTIN2

136

Q15019
RLCHDNNEDHQLDRF

RCHY1

41

Q96PM5
IGQHCQVEHCRQRDF

ZFAND1

6

Q8TCF1
EHRRQQHFSHRCQLC

ZNF142

1371

P52746
QHFSHRCQLCDFAAR

ZNF142

1376

P52746
HQFIHLLCRVAINCE

USP34

3146

Q70CQ2
ANCTVRDHVHCLGNR

TM2D3

156

Q9BRN9
AHSRQKLFTCRECHQ

ZNF337

201

Q9Y3M9