Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	adenosylhomocysteinase activity	AHCYL1 AHCYL2	7.73e-05	3	102	2	GO:0004013
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-sulfur bonds	AHCYL1 AHCYL2	7.73e-05	3	102	2	GO:0046508
GeneOntologyMolecularFunction	DNA binding domain binding	PPARG RXRA	3.82e-04	6	102	2	GO:0050692
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	3.82e-04	6	102	2	GO:0034647
GeneOntologyMolecularFunction	LBD domain binding	PPARG RXRA	5.34e-04	7	102	2	GO:0050693
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5C KDM5D	7.09e-04	8	102	2	GO:0032453
GeneOntologyMolecularFunction	myosin light chain binding	SPATA6 MYO19	7.09e-04	8	102	2	GO:0032027
GeneOntologyBiologicalProcess	regulation of hyaluronan biosynthetic process	EGF CLTC SMPD3	9.09e-06	9	100	3	GO:1900125
GeneOntologyBiologicalProcess	nuclear receptor-mediated signaling pathway	VPS18 KDM5D PPARG RXRA PGR TRIM16 NCOR2	5.78e-05	202	100	7	GO:0141193
GeneOntologyBiologicalProcess	hyaluronan biosynthetic process	EGF CLTC SMPD3	5.91e-05	16	100	3	GO:0030213
Domain	S-Ado-L-homoCys_hydrolase_CS	AHCYL1 AHCYL2	8.83e-05	3	102	2	IPR020082
Domain	AdoHcyase_NAD	AHCYL1 AHCYL2	8.83e-05	3	102	2	SM00997
Domain	AdoHcyase	AHCYL1 AHCYL2	8.83e-05	3	102	2	SM00996
Domain	AdoHcyase_NAD	AHCYL1 AHCYL2	8.83e-05	3	102	2	PF00670
Domain	ADOHCYASE_1	AHCYL1 AHCYL2	8.83e-05	3	102	2	PS00738
Domain	ADOHCYASE_2	AHCYL1 AHCYL2	8.83e-05	3	102	2	PS00739
Domain	AdoHcyase	AHCYL1 AHCYL2	8.83e-05	3	102	2	PF05221
Domain	Adenosylhomocysteinase	AHCYL1 AHCYL2	8.83e-05	3	102	2	IPR000043
Domain	Ado_hCys_hydrolase_NAD-bd	AHCYL1 AHCYL2	8.83e-05	3	102	2	IPR015878
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	1.76e-04	4	102	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	1.76e-04	4	102	2	PF08429
Domain	zf-C5HC2	KDM5C KDM5D	2.92e-04	5	102	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	2.92e-04	5	102	2	IPR004198
Domain	Clathrin	VPS18 CLTC	6.09e-04	7	102	2	PF00637
Domain	CHCR	VPS18 CLTC	6.09e-04	7	102	2	PS50236
Domain	Clathrin_H-chain/VPS_repeat	VPS18 CLTC	8.09e-04	8	102	2	IPR000547
Domain	WD_REPEATS_1	DCAF6 KATNB1 WDHD1 TLE3 WRAP73 RIC1 WDTC1	8.32e-04	278	102	7	PS00678
Domain	WD_REPEATS_2	DCAF6 KATNB1 WDHD1 TLE3 WRAP73 RIC1 WDTC1	8.49e-04	279	102	7	PS50082
Domain	WD_REPEATS_REGION	DCAF6 KATNB1 WDHD1 TLE3 WRAP73 RIC1 WDTC1	8.49e-04	279	102	7	PS50294
Domain	WD40_repeat_dom	DCAF6 KATNB1 LRRK1 WDHD1 TLE3 RIC1 WDTC1	1.22e-03	297	102	7	IPR017986
Domain	JmjN	KDM5C KDM5D	1.29e-03	10	102	2	SM00545
Domain	JMJN	KDM5C KDM5D	1.29e-03	10	102	2	PS51183
Domain	JmjN	KDM5C KDM5D	1.29e-03	10	102	2	PF02375
Domain	JmjN	KDM5C KDM5D	1.29e-03	10	102	2	IPR003349
Domain	TPR-like_helical_dom	LONRF1 CLTC HELZ PRKDC CABIN1 WDTC1	1.76e-03	233	102	6	IPR011990
Domain	zf-C4	PPARG RXRA PGR	2.02e-03	46	102	3	PF00105
Domain	Znf_hrmn_rcpt	PPARG RXRA PGR	2.02e-03	46	102	3	IPR001628
Domain	Nuclear_hrmn_rcpt	PPARG RXRA PGR	2.02e-03	46	102	3	IPR001723
Domain	NUCLEAR_REC_DBD_2	PPARG RXRA PGR	2.02e-03	46	102	3	PS51030
Domain	NUCLEAR_REC_DBD_1	PPARG RXRA PGR	2.02e-03	46	102	3	PS00031
Domain	ZnF_C4	PPARG RXRA PGR	2.02e-03	46	102	3	SM00399
Domain	6-blade_b-propeller_TolB-like	LRP1B EGF WRAP73	2.02e-03	46	102	3	IPR011042
Domain	-	PPARG RXRA PGR	2.15e-03	47	102	3	1.10.565.10
Domain	HOLI	PPARG RXRA PGR	2.29e-03	48	102	3	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	PPARG RXRA PGR	2.29e-03	48	102	3	IPR000536
Domain	Hormone_recep	PPARG RXRA PGR	2.29e-03	48	102	3	PF00104
Domain	-	DCAF6 KATNB1 WDHD1 TLE3 WRAP73 RIC1 WDTC1	2.34e-03	333	102	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	DCAF6 KATNB1 WDHD1 TLE3 WRAP73 RIC1 WDTC1	2.42e-03	335	102	7	IPR015943
Domain	-	DNHD1 RRAS2 TRIT1 GIMAP5 MYO19 MCM7 LRRK1 RHOV N4BP2 HELZ DNAH9	2.51e-03	746	102	11	3.40.50.300
Domain	Dynein_HC_stalk	DNHD1 DNAH9	2.57e-03	14	102	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH9	2.57e-03	14	102	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH9	2.57e-03	14	102	2	PF08393
Domain	MT	DNHD1 DNAH9	2.57e-03	14	102	2	PF12777
Domain	Ldl_recept_b	LRP1B EGF	2.57e-03	14	102	2	PF00058
Domain	LDLRB	LRP1B EGF	2.57e-03	14	102	2	PS51120
Domain	DHC_fam	DNHD1 DNAH9	2.96e-03	15	102	2	IPR026983
Domain	-	KDM5C KDM5D	2.96e-03	15	102	2	1.10.150.60
Domain	BRIGHT	KDM5C KDM5D	2.96e-03	15	102	2	SM00501
Domain	ARID_dom	KDM5C KDM5D	2.96e-03	15	102	2	IPR001606
Domain	ARID	KDM5C KDM5D	2.96e-03	15	102	2	PS51011
Domain	ARID	KDM5C KDM5D	2.96e-03	15	102	2	PF01388
Domain	Dynein_heavy_dom	DNHD1 DNAH9	2.96e-03	15	102	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH9	2.96e-03	15	102	2	PF03028
Domain	LY	LRP1B EGF	2.96e-03	15	102	2	SM00135
Domain	LDLR_classB_rpt	LRP1B EGF	2.96e-03	15	102	2	IPR000033
Domain	WD40	DCAF6 KATNB1 WDHD1 TLE3 WRAP73 WDTC1	2.98e-03	259	102	6	PF00400
Domain	BTB_2	KCND1 KCNG4 KCTD18	3.04e-03	53	102	3	PF02214
Domain	T1-type_BTB	KCND1 KCNG4 KCTD18	3.04e-03	53	102	3	IPR003131
Domain	WD40	DCAF6 KATNB1 WDHD1 TLE3 WRAP73 WDTC1	3.52e-03	268	102	6	SM00320
Domain	Ion_trans_dom	ITPR1 KCND1 KCNG4 TRPV3	3.53e-03	114	102	4	IPR005821
Domain	Ion_trans	ITPR1 KCND1 KCNG4 TRPV3	3.53e-03	114	102	4	PF00520
Domain	-	PPARG RXRA PGR	3.74e-03	57	102	3	3.30.50.10
Domain	WD40_repeat	DCAF6 KATNB1 WDHD1 TLE3 WRAP73 WDTC1	3.79e-03	272	102	6	IPR001680
Domain	Znf_NHR/GATA	PPARG RXRA PGR	3.92e-03	58	102	3	IPR013088
Domain	Apc4_WD40_dom	WDHD1 WRAP73	5.26e-03	20	102	2	IPR024977
Domain	ANAPC4_WD40	WDHD1 WRAP73	5.26e-03	20	102	2	PF12894
Domain	Zinc_finger_PHD-type_CS	KDM5C KDM5D KMT2E	5.41e-03	65	102	3	IPR019786
Pathway	BIOCARTA_EGFR_SMRTE_PATHWAY	RXRA NCOR2 EGF	2.60e-05	11	78	3	M18837
Pathway	BIOCARTA_EGFR_SMRTE_PATHWAY	RXRA NCOR2 EGF	2.60e-05	11	78	3	MM1432
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	RXRA NCOR2 TGS1	1.25e-04	18	78	3	MM15034
Pathway	REACTOME_CYTOPROTECTION_BY_HMOX1	RXRA NCOR2 ALB TGS1	1.92e-04	52	78	4	MM15684
Pathway	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	PPARG RXRA PGR NCOR2	2.07e-04	53	78	4	M8276
Pubmed	An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage.	AHCYL1 AHCYL2 ITPR1	2.52e-08	3	103	3	19220705
Pubmed	A selective peroxisome proliferator-activated receptor-gamma modulator, telmisartan, binds to the receptor in a different fashion from thiazolidinediones.	PPARG RXRA NCOR2	1.01e-07	4	103	3	19147680
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	AHCYL1 CLSTN3 DCAF6 DSP LONRF1 APC2 SRI DEF8 LRP1B MADD LMO2 ASPA CLTC PRKDC SMPD3 GFPT2 CABIN1	2.30e-07	1285	103	17	35914814
Pubmed	Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells.	PPARG RXRA NCOR2	2.51e-07	5	103	3	23703729
Pubmed	Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans.	PPARG RXRA NCOR2	2.51e-07	5	103	3	20364085
Pubmed	Impaired peroxisome proliferator-activated receptor gamma function through mutation of a conserved salt bridge (R425C) in familial partial lipodystrophy.	PPARG RXRA NCOR2	5.01e-07	6	103	3	17312272
Pubmed	Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.	PPARG RXRA NCOR2	8.75e-07	7	103	3	11903058
Pubmed	Enhancer activation requires trans-recruitment of a mega transcription factor complex.	RXRA NCOR2 PRKDC	2.98e-06	10	103	3	25303530
Pubmed	Natural helix 9 mutants of PPARγ differently affect its transcriptional activity.	PPARG RXRA NCOR2	2.98e-06	10	103	3	30595551
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DSP KDM5C MINK1 TRIM16 NCOR2 ESYT2 WDHD1 TLE3 ZNF516 CLTC HELZ PRKDC	3.26e-06	774	103	12	15302935
Pubmed	USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma.	DSP PPARG PRKDC	4.09e-06	11	103	3	35449157
Pubmed	Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.	PPARG RXRA NCOR2	4.09e-06	11	103	3	15681609
Pubmed	Binding of IRBIT to the IP3 receptor: determinants and functional effects.	AHCYL1 ITPR1	8.69e-06	2	103	2	16527252
Pubmed	The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion.	PPARG RXRA	8.69e-06	2	103	2	12485829
Pubmed	Association between PPAR-γ and RXR-α gene polymorphism and metabolic syndrome risk: a case-control study of a Chinese Han population.	PPARG RXRA	8.69e-06	2	103	2	22475777
Pubmed	Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha.	PPARG RXRA	8.69e-06	2	103	2	7838715
Pubmed	Tissue transglutaminase is an essential participant in the epidermal growth factor-stimulated signaling pathway leading to cancer cell migration and invasion.	TGM2 EGF	8.69e-06	2	103	2	19403524
Pubmed	Distinct mechanisms of glucose lowering by specific agonists for peroxisomal proliferator activated receptor gamma and retinoic acid X receptors.	PPARG RXRA	8.69e-06	2	103	2	16179348
Pubmed	Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.	PPARG RXRA	8.69e-06	2	103	2	28740126
Pubmed	Tissue transglutaminase activation modulates inflammation in cystic fibrosis via PPARgamma down-regulation.	PPARG TGM2	8.69e-06	2	103	2	18490773
Pubmed	Retinoid X receptor alpha (RXRα) and peroxisome proliferator-activated receptor gamma (PPARγ) expression in breast cancer: an immunohistochemical study.	PPARG RXRA	8.69e-06	2	103	2	22210720
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	8.69e-06	2	103	2	10441747
Pubmed	Phosphorylation of PPARγ Affects the Collective Motions of the PPARγ-RXRα-DNA Complex.	PPARG RXRA	8.69e-06	2	103	2	25954810
Pubmed	Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists.	PPARG RXRA	8.69e-06	2	103	2	9065481
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	8.69e-06	2	103	2	16416087
Pubmed	Genetic variants in peroxisome proliferator-activated receptor-γ and retinoid X receptor-α gene and type 2 diabetes risk: a case-control study of a Chinese Han population.	PPARG RXRA	8.69e-06	2	103	2	21284483
Pubmed	Connexin 31.1 degradation requires the Clathrin-mediated autophagy in NSCLC cell H1299.	GJB5 CLTC	8.69e-06	2	103	2	25388970
Pubmed	Course of Brugia malayi infection in C57BL/6J NOS2 +/+ and -/- mice.	PRKDC NOS2	8.69e-06	2	103	2	11426950
Pubmed	IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor.	AHCYL1 ITPR1	8.69e-06	2	103	2	16793548
Pubmed	Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs.	ITPR1 PLK1	8.69e-06	2	103	2	18621368
Pubmed	PPARγ and RXR ligands disrupt the inflammatory cross-talk in the hypoxic breast cancer stem cells niche.	PPARG RXRA	8.69e-06	2	103	2	24604522
Pubmed	Myotubularin-Related Protein14 Prevents Neointima Formation and Vascular Smooth Muscle Cell Proliferation by Inhibiting Polo-Like Kinase1.	MTMR14 PLK1	8.69e-06	2	103	2	36314496
Pubmed	Low-resolution molecular models reveal the oligomeric state of the PPAR and the conformational organization of its domains in solution.	PPARG RXRA	8.69e-06	2	103	2	22363753
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	8.69e-06	2	103	2	32081420
Pubmed	Correlation of Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) and Retinoid X Receptor-alpha (RXR-alpha) expression with clinical risk factors in patients with advanced carotid atherosclerosis.	PPARG RXRA	8.69e-06	2	103	2	21709632
Pubmed	Augmentation of tissue transglutaminase expression and activation by epidermal growth factor inhibit doxorubicin-induced apoptosis in human breast cancer cells.	TGM2 EGF	8.69e-06	2	103	2	15272014
Pubmed	Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guérin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity.	PRKDC NOS2	8.69e-06	2	103	2	17982083
Pubmed	Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.	PPARG RXRA	8.69e-06	2	103	2	10882139
Pubmed	Cytoplasmic Colocalization of RXRα and PPARγ as an Independent Negative Prognosticator for Breast Cancer Patients.	PPARG RXRA	8.69e-06	2	103	2	35406808
Pubmed	MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1.	KMT2E PLK1	8.69e-06	2	103	2	27002166
Pubmed	Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis.	PRKDC PLK1	8.69e-06	2	103	2	24844881
Pubmed	The Catalytic Subunit of DNA-Dependent Protein Kinase Coordinates with Polo-Like Kinase 1 to Facilitate Mitotic Entry.	PRKDC PLK1	8.69e-06	2	103	2	25925375
Pubmed	Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes.	PPARG RXRA	8.69e-06	2	103	2	17301838
Pubmed	Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor.	AHCYL1 ITPR1	8.69e-06	2	103	2	17635105
Pubmed	Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability.	RXRA PLK1	8.69e-06	2	103	2	33321102
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	8.69e-06	2	103	2	7524912
Pubmed	IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor.	AHCYL1 ITPR1	8.69e-06	2	103	2	12525476
Pubmed	Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis.	PPARG PRKDC	8.69e-06	2	103	2	17312139
Pubmed	Effect of heterodimer partner RXRalpha on PPARgamma activation function-2 helix in solution.	PPARG RXRA	8.69e-06	2	103	2	17980149
Pubmed	Polo-like kinase1 is required for recruitment of dynein to kinetochores during mitosis.	DNHD1 PLK1	8.69e-06	2	103	2	21507953
Pubmed	RXRα is upregulated in first trimester endometrial glands of spontaneous abortions unlike LXR and PPARγ.	PPARG RXRA	8.69e-06	2	103	2	28076928
Pubmed	Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors.	ITPR1 TGM2	8.69e-06	2	103	2	25201980
Pubmed	Peroxisome proliferator-activated receptor gamma-mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms.	PPARG RXRA	8.69e-06	2	103	2	12591919
Pubmed	De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis.	PPARG RXRA	8.69e-06	2	103	2	19300518
Pubmed	Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse.	RXRA ALB	8.69e-06	2	103	2	15282742
Pubmed	Regulation of Epigenetic Modifications in the Placenta during Preeclampsia: PPARγ Influences H3K4me3 and H3K9ac in Extravillous Trophoblast Cells.	PPARG RXRA	8.69e-06	2	103	2	34830351
Pubmed	Sorcin links calcium signaling to vesicle trafficking, regulates Polo-like kinase 1 and is necessary for mitosis.	SRI PLK1	8.69e-06	2	103	2	24427308
Pubmed	Peroxisome proliferator-activated receptor gamma is a target of progesterone regulation in the preovulatory follicles and controls ovulation in mice.	PPARG PGR	8.69e-06	2	103	2	18172011
Pubmed	Interactions that determine the assembly of a retinoid X receptor/corepressor complex.	RXRA NCOR2	8.69e-06	2	103	2	11972046
Pubmed	Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.	PPARG RXRA	8.69e-06	2	103	2	19043829
Pubmed	Functional genetic dissection of nuclear receptor signalling in obesity, diabetes and liver regeneration using spatiotemporally controlled somatic mutagenesis in the mouse.	PPARG RXRA	8.69e-06	2	103	2	14529153
Pubmed	A PPARgamma mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus.	PPARG RXRA	8.69e-06	2	103	2	10854698
Pubmed	Manipulation of reciprocal salt bridges at the heterodimerization interface alters the dimerization properties of mouse RXRalpha and PPARgamma1.	PPARG RXRA	8.69e-06	2	103	2	17521607
Pubmed	DNA-PKcs associates with PLK1 and is involved in proper chromosome segregation and cytokinesis.	PRKDC PLK1	8.69e-06	2	103	2	24166892
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	8.69e-06	2	103	2	9060413
Pubmed	Serum epidermal growth factor is associated with prognosis and hormone receptor status in patients with HER2-positive metastatic breast cancer treated with first-line trastuzumab plus taxane chemotherapy.	PGR EGF	8.69e-06	2	103	2	24036907
Pubmed	PPARγ population shift produces disease-related changes in molecular networks associated with metabolic syndrome.	PPARG RXRA	8.69e-06	2	103	2	21833030
Pubmed	SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis.	PPARG NCOR2	8.69e-06	2	103	2	19066220
Pubmed	Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.	PPARG TLE3	8.69e-06	2	103	2	25249007
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	DSP ZNF185 KATNB1 SHB ARHGEF11 LRP1B ESYT2 MTMR14 N4BP2 WRAP73 XRN1 PLK1	8.70e-06	853	103	12	28718761
Pubmed	Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.	PPARG RXRA PGR	8.97e-06	14	103	3	12039952
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	RRAS2 DSP ORC3 KDM5C PPARG RXRA NCOR2 ESYT2 WDHD1 TLE3 ALB CABIN1	9.12e-06	857	103	12	25609649
Pubmed	CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1.	AHCYL1 AHCYL2 ZNF516 INTS15 PRKDC	1.31e-05	101	103	5	34462429
Pubmed	A human MAP kinase interactome.	DSP MUC12 ARHGEF11 MADD N4BP2 CLTC HELZ PRKDC ABLIM2	1.48e-05	486	103	9	20936779
Pubmed	Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.	PPARG RXRA TGS1	1.66e-05	17	103	3	28291835
Pubmed	Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.	MCM7 XRN1 HELZ PRKDC PLK1	1.73e-05	107	103	5	30995489
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	DCAF6 ZFAT DSP SHB KMT2E MTMR14 CLTC ABLIM2 TGS1	1.77e-05	497	103	9	23414517
Pubmed	Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.	PPARG RXRA TGS1	2.36e-05	19	103	3	22982455
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LONRF1 GRK5 LRRK1 ARHGEF11 MADD NCOR2 URB1 MTMR14 ZNF516 BAMBI PRKDC CABIN1 RIC1	2.38e-05	1105	103	13	35748872
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	AHCYL1 ORC3 MYO19 MINK1 MADD ITPR1 TGM2 XRN1 HELZ RIC1	2.41e-05	650	103	10	38777146
Pubmed	Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.	VPS18 ZFAT PCDHAC1 GJB5 RHOV KCNG4	2.47e-05	193	103	6	22589738
Pubmed	A novel pathway involving progesterone receptor, 12/15-lipoxygenase-derived eicosanoids, and peroxisome proliferator-activated receptor gamma regulates implantation in mice.	PPARG PGR	2.60e-05	3	103	2	14688261
Pubmed	15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells.	PPARG RXRA	2.60e-05	3	103	2	16156795
Pubmed	PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation.	PPARG RXRA	2.60e-05	3	103	2	30404011
Pubmed	Enzyme association with PPARgamma: evidence of a new role for 15-lipoxygenase type 2.	PPARG RXRA	2.60e-05	3	103	2	15698583
Pubmed	The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop.	PPARG RXRA	2.60e-05	3	103	2	19414603
Pubmed	Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses.	PPARG RXRA	2.60e-05	3	103	2	17008383
Pubmed	Hepatic scavenger receptor class B, type I is stimulated by peroxisome proliferator-activated receptor gamma and hepatocyte nuclear factor 4alpha.	PPARG RXRA	2.60e-05	3	103	2	12763030
Pubmed	Identification of a signaling pathway involving progesterone receptor, calcitonin, and tissue tranglutaminase in Ishikawa endometrial cells.	PGR TGM2	2.60e-05	3	103	2	16439457
Pubmed	Nuclear receptors gene polymorphisms and risk of restenosis and clinical events following coronary stenting.	PPARG RXRA	2.60e-05	3	103	2	20070029
Pubmed	Ligands of peroxisome proliferator-activated receptor inhibit homocysteine-induced DNA methylation of inducible nitric oxide synthase gene.	PPARG NOS2	2.60e-05	3	103	2	17492134
Pubmed	Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host.	PRKDC NOS2	2.60e-05	3	103	2	21576322
Pubmed	Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans.	PRKDC NOS2	2.60e-05	3	103	2	21576342
Pubmed	PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL.	PPARG RXRA	2.60e-05	3	103	2	9568716
Pubmed	IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.	AHCYL1 ITPR1	2.60e-05	3	103	2	27995898
Pubmed	Peroxisome proliferator-activated receptor γ agonists induce cell cycle arrest through transcriptional regulation of Kruppel-like factor 4 (KLF4).	PPARG RXRA	2.60e-05	3	103	2	23275339
Pubmed	The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor.	PPARG RXRA	2.60e-05	3	103	2	14671211
Pubmed	Zn2+ is essential for Ca2+ oscillations in mouse eggs.	ITPR1 TRPV3	2.60e-05	3	103	2	38099643
Pubmed	Peroxisome proliferator-activated receptor gamma activation inhibits progesterone-stimulated human MUC1 expression.	PPARG PGR	2.60e-05	3	103	2	20484415
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	2.60e-05	3	103	2	7544442
Cytoband	8q11	PRKDC TGS1	7.43e-05	6	103	2	8q11
GeneFamily	WD repeat domain containing	DCAF6 KATNB1 WDHD1 TLE3 WRAP73 WDTC1	4.16e-04	262	67	6	362
GeneFamily	Nuclear hormone receptors	PPARG RXRA PGR	7.93e-04	49	67	3	71
GeneFamily	LIM domain containing	ZNF185 LMO2 ABLIM2	1.36e-03	59	67	3	1218
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	1.38e-03	15	67	2	418
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	DCAF6 WDTC1	1.99e-03	18	67	2	498
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	3.54e-03	24	67	2	485
GeneFamily	PHD finger proteins	KDM5C KDM5D KMT2E	4.54e-03	90	67	3	88
Drug	rosavin	PPARG RXRA PGR EGF NOS2	3.14e-07	32	103	5	ctd:C529148
Drug	Chlorogenic Acid	PPARG RXRA PGR EGF BAMBI ALB NOS2	4.38e-07	103	103	7	ctd:D002726
Drug	osajin	PPARG RXRA PGR EGF NOS2	5.79e-07	36	103	5	ctd:C485800
Drug	Vitamin D	PPARG RXRA TGM2 NCOR2 ALB	1.33e-05	67	103	5	ctd:D014807
Drug	Etoposide	AHCYL1 HTR4 MATN2 MCM7 RXRA ITPR1 EGF INTS15 BAMBI PRKDC PLK1 NOS2	1.39e-05	587	103	12	ctd:D005047
Drug	1,1-bis(3'-indolyl)-1-(4-trifluoromethylphenyl)methane	PPARG NCOR2 NOS2	1.44e-05	11	103	3	ctd:C492909
Drug	MDL-28842	AHCYL1 AHCYL2 EGF	1.92e-05	12	103	3	CID006441200
Drug	2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID	PPARG RXRA	2.03e-05	2	103	2	DB08402
Drug	sorbitan monooleate	PPARG RXRA	2.03e-05	2	103	2	ctd:C018665
Drug	allyl isocyanate	BAMBI ALB	2.03e-05	2	103	2	CID000015123
Drug	4-trifluoromethylaniline	SHB BAMBI	2.03e-05	2	103	2	CID000009964
Drug	2-chloro-5-nitro-N-phenylbenzamide	PPARG RXRA	2.03e-05	2	103	2	DB07863
Drug	Halofenate	PPARG ALB	2.03e-05	2	103	2	ctd:D006218
Drug	Trolox [53188-07-1]; Down 200; 16uM; PC3; HT_HG-U133A	KDM5C GRK5 MINK1 TGM2 TLE3 CABIN1 DMAC2L	3.31e-05	198	103	7	7304_DN
Drug	Tetrahydrozoline hydrochloride [522-48-5]; Down 200; 16.8uM; MCF7; HT_HG-U133A	MINK1 KATNB1 SRI AHCYL2 PPARG WDHD1 ZMYM6	3.42e-05	199	103	7	6069_DN
Drug	Brompheniramine maleate [980-71-2]; Up 200; 9.2uM; MCF7; HT_HG-U133A	CLSTN3 ARHGEF11 TGM2 URB1 ZNF516 CDK5R2 ZMYM6	3.42e-05	199	103	7	3271_UP
Drug	acyclic retinoid	RXRA TGM2 EGF CLTC	3.52e-05	41	103	4	CID006437836
Drug	4-methylbenzaldehyde	PPARG PGR NOS2	3.93e-05	15	103	3	ctd:C020627
Drug	Terlipressin	HTR4 ALB NOS2	3.93e-05	15	103	3	CID000072081
Drug	phthalic acid	PPARG RXRA PGR	5.84e-05	17	103	3	ctd:C032279
Drug	isophorone	PPARG PGR	6.06e-05	3	103	2	ctd:C005940
Drug	N6-hydroxyadenosine	AHCYL1 AHCYL2	6.06e-05	3	103	2	CID000018881
Drug	4-(bromomethyl)phenol	PGR ALB	6.06e-05	3	103	2	CID000041663
Drug	2-trifluoromethylaniline	SHB BAMBI	6.06e-05	3	103	2	CID000006922
Drug	AC1L2XHC	PGR EGF	6.06e-05	3	103	2	CID000130491
Drug	2-(2-(4-phenoxy-2-propylphenoxy)ethyl)indole-5-acetic acid	PPARG RXRA	6.06e-05	3	103	2	ctd:C483845
Disease	pancreatic ductal carcinoma (is_marker_for)	MCM7 PPARG RXRA EGF ALB	2.07e-06	61	100	5	DOID:3587 (is_marker_for)
Disease	smoking status measurement, aggressive periodontitis	GRK5 ABLIM2	3.40e-05	3	100	2	EFO_0006342, EFO_0006527
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	6.79e-05	4	100	2	DOID:0060809 (implicated_via_orthology)
Disease	alcoholic cardiomyopathy (biomarker_via_orthology)	PPARG RXRA	6.79e-05	4	100	2	DOID:12935 (biomarker_via_orthology)
Disease	Subarachnoid Hemorrhage, Aneurysmal	PPARG NOS2	3.14e-04	8	100	2	C0751530
Disease	Subarachnoid Hemorrhage, Spontaneous	PPARG NOS2	3.14e-04	8	100	2	C0472383
Disease	Subarachnoid Hemorrhage, Intracranial	PPARG NOS2	3.14e-04	8	100	2	C0795688
Disease	Perinatal Subarachnoid Hemorrhage	PPARG NOS2	3.14e-04	8	100	2	C0270192
Disease	Hepatic Insufficiency	ALB NOS2	4.03e-04	9	100	2	C1306571
Disease	Subarachnoid Hemorrhage	PPARG NOS2	4.03e-04	9	100	2	C0038525
Disease	alcohol use disorder (implicated_via_orthology)	KDM5C GRK5 GPR52 KDM5D MADD	5.42e-04	195	100	5	DOID:1574 (implicated_via_orthology)
Disease	Congestive heart failure	PPARG BAMBI ALB NOS2	5.44e-04	110	100	4	C0018802
Disease	Heart failure	PPARG BAMBI ALB NOS2	5.44e-04	110	100	4	C0018801
Disease	Left-Sided Heart Failure	PPARG BAMBI ALB NOS2	5.44e-04	110	100	4	C0023212
Disease	Heart Failure, Right-Sided	PPARG BAMBI ALB NOS2	5.44e-04	110	100	4	C0235527
Disease	Heart Decompensation	PPARG BAMBI ALB NOS2	5.44e-04	110	100	4	C1961112
Disease	Myocardial Failure	PPARG BAMBI ALB NOS2	5.44e-04	110	100	4	C1959583
Disease	endometrial carcinoma, endometriosis	TFAP2D PGR	6.13e-04	11	100	2	EFO_0001065, EFO_1001512
Disease	plasminogen activator inhibitor 1 measurement	MUC12 PPARG TMEM232	8.26e-04	54	100	3	EFO_0004792
Disease	Acute Cerebrovascular Accidents	HTR4 ALB NOS2	8.26e-04	54	100	3	C0751956
Disease	gallbladder cancer (is_implicated_in)	LRP1B EGF	8.66e-04	13	100	2	DOID:3121 (is_implicated_in)
Disease	leukemia	KMT2E SMPD3 PLK1	8.72e-04	55	100	3	C0023418
Disease	Sarcomatoid Renal Cell Carcinoma	DNHD1 KDM5C LRP1B TGM2	9.60e-04	128	100	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	DNHD1 KDM5C LRP1B TGM2	9.60e-04	128	100	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	DNHD1 KDM5C LRP1B TGM2	9.60e-04	128	100	4	C1266044
Disease	Papillary Renal Cell Carcinoma	DNHD1 KDM5C LRP1B TGM2	9.60e-04	128	100	4	C1306837
Disease	Renal Cell Carcinoma	DNHD1 KDM5C LRP1B TGM2	9.60e-04	128	100	4	C0007134
Disease	mood instability measurement	HTR4 LRP1B TMEM232 FBXO31	9.60e-04	128	100	4	EFO_0008475
Disease	pulmonary emphysema (is_marker_for)	ALB SMPD3	1.01e-03	14	100	2	DOID:9675 (is_marker_for)
Disease	Malignant neoplasm of breast	TFAP2D APC2 COG3 PGR TGM2 ZNF22 EGF N4BP2 TLE3 DNAH9 NOS2	1.04e-03	1074	100	11	C0006142
Disease	Global developmental delay	TRIT1 KDM5C APC2 KMT2E	1.11e-03	133	100	4	C0557874
Disease	Cerebrovascular accident	HTR4 ALB NOS2	1.24e-03	62	100	3	C0038454
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	1.32e-03	16	100	2	DOID:0050888 (implicated_via_orthology)
Disease	Cardiovascular Abnormalities	APC2 NOS2	1.32e-03	16	100	2	C0243050
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	DNHD1 KDM5C LRP1B TGM2	1.64e-03	148	100	4	C0279702
Disease	Gastric ulcer	EGF NOS2	1.68e-03	18	100	2	C0038358
Disease	epilepsy (implicated_via_orthology)	MINK1 LRP1B NOS2 CDK5R2	2.33e-03	163	100	4	DOID:1826 (implicated_via_orthology)
Disease	cholangiocarcinoma (is_implicated_in)	WDHD1 ALB	2.51e-03	22	100	2	DOID:4947 (is_implicated_in)
Disease	high density lipoprotein particle size measurement	AHCYL1 PPARG MADD NCOR2	2.71e-03	170	100	4	EFO_0008592
Disease	Giant Cell Glioblastoma	PPARG TGM2 EGF	2.95e-03	84	100	3	C0334588
Disease	Kidney Diseases	EGF ALB NOS2	3.36e-03	88	100	3	C0022658

Protein segments in the cluster

Peptide	Gene	Start	Entry
CEIDLEIKRYFCRAG	ESYT2	276	A0FGR8
ECADDRADLAKYICE	ALB	276	P02768
RLESREVIECLYACR	CLSTN3	536	Q9BQT9
EAVRRLLASKCRCYS	B3GLCT	401	Q6Y288
DDYVACCVKLRALTD	GCA	176	P28676
LCRARDQCREILKYV	ARHGEF11	906	O15085
RCDSCEKYITGRVLE	ABLIM2	211	Q6H8Q1
DCKDDILINCRRAAT	DCAF6	181	Q58WW2
CDRLDSPRERSYCAK	DNHD1	2656	Q96M86
LCKCHYIEDDCLLRL	DMAC2L	131	Q99766
GDFVCRRCYRLKELS	CDK5R2	191	Q13319
CLDEQRRELGCLDAY	TFAP2D	126	Q7Z6R9
DGLCASCDKRIRAYE	LMO2	91	P25791
RKETRYFCAECDVPL	PGBD4	556	Q96DM1
FRADCSICLYSIERK	RIC1	601	Q4ADV7
VRLAKALVDDYCCLV	INTS15	146	Q96N11
LVDILYSALRCCDND	LTN1	681	O94822
CMDKYRLSCLEEERL	NOS2	571	P35228
ARALERACYEESLKS	NCOR2	1496	Q9Y618
KRSYHLCDLCDRIII	TRIT1	391	Q9H3H1
ELVGDCCLEEYRDRK	KCND1	126	Q9NSA2
DEKLLYCENRSCRRG	LRP1B	2541	Q9NZR2
NEDLKTCSRVDYCLL	MATN2	476	O00339
ECLYTLKRLVDCCSE	MADD	191	Q8WXG6
LDYRISCLLCIFKRE	ITPR1	996	Q14643
RIEKRCLELFGRDYC	MTMR14	56	Q8NCE2
IDCASLEICRRLEPY	LRRK1	1716	Q38SD2
ECDTRRDCLAKLIYA	MYO19	371	Q96H55
CKESLKEYLADRRYC	LONRF1	516	Q17RB8
LRAEEDQGECSRKCY	KCNG4	246	Q8TDN1
LRRYCVFSHEELICK	KDM5D	626	Q9BY66
DISREERLHKCRLCY	KATNB1	606	Q9BVA0
DEALDYICKLCASLD	DDX58	421	O95786
CREEYGVCENLRKLE	FBXO31	111	Q5XUX0
DTERYILLCRNKLSC	DEFB125	41	Q8N687
DTYLCERCQPRNLDK	KMT2E	156	Q8IZD2
SAYSVSACRLRCEKE	ASIC4	311	Q96FT7
TTYEKRQRADDPCCL	SMPD3	41	Q9NY59
CLACISVDRYLAITK	GPR52	131	Q9Y2T5
YIFLRLSRECCEELN	HELZ	566	P42694
ELVDSICENARRYAK	MCM7	61	P33993
CSLKDLVRECERRYC	GIMAP5	171	Q96F15
ADREQLCRAKAACVL	PCDHAC1	81	Q9H158
LCRAKAACVLTYDLV	PCDHAC1	86	Q9H158
YLCAGRNDCIVDKIR	PGR	601	P06401
CIYTARRESLCRFKD	KCTD18	21	Q6PI47
YVKRFLDIADCRERC	APC2	1236	O95996
SLLRLKDYRQCFECS	CABIN1	746	Q9Y6J0
ETADTLLALRYCKDR	GFPT2	426	O94808
VLLTKGEIRCYCDAA	BAMBI	21	Q13145
ALSRDRKYCEDVNEC	EGF	346	P01133
RDILCKALASYVAAC	FCGBP	1916	Q9Y6R7
TLVCLSKLYRCIDRA	COG3	561	Q96JB2
CERVLLGASCRDYLL	FNDC10	121	F2Z333
TLERLRRCALCYDKC	COL6A5	1931	A8TX70
TVCLDLDKVEAYRCG	DSP	796	P15924
RAFLIILCCDDERYR	HTR4	321	Q13639
ILCCDDERYRRPSIL	HTR4	326	Q13639
LDSQDYRCAECRAPI	DEF8	271	Q6ZN54
YVVCARCSDYRAELK	FGD2	486	Q7Z6J4
LVIYDGKECRAESCL	IP6K1	336	Q92551
GRLCLCEKALAEYLD	DNAH9	1581	Q9NYC9
QCEDLRRTIDRDYCS	GRK5	41	P34947
RRTIDRDYCSLCDKQ	GRK5	46	P34947
IYLVSKRCHECLAAR	GJB5	206	O95377
DLTYTCRDNKDCLID	RXRA	166	P19793
DEKSRRILAALCQDY	DIPK1C	56	Q0P6D2
LGRQIRELYCTCLEK	ORC3	431	Q9UBD5
KEDCIAYICREILRG	MINK1	126	Q8N4C8
AYTGILCEKLRCEEA	NTNG1	491	Q9Y2I2
LYCCRESILDGLKRT	AHCYL2	371	Q96HN2
ENLLRLCKECSYLVR	SHB	421	Q15464
LCRTRLKEYEQCIDI	HPS3	896	Q969F9
YCCRESILDGLKRTT	AHCYL1	291	O43865
TIRLKLIYDRCDLNC	PPARG	166	P37231
YTKQCVIDDRAARLD	RRAS2	51	P62070
AERRDCKDYVSIFVC	WRAP73	151	Q9P2S5
IRDKQCYELCARRGI	URB1	1796	O60287
CTRYIDCDLNRIFDL	ASPA	61	P45381
IKEVERICRESNCYD	CLTC	741	Q00610
DAASCDISYRRICEK	CLEC5A	171	Q9NY25
EEYVCRLLLCARTVS	TGM2	501	P21980
RAEASCPICLDYLKD	TRIM61	11	Q5EBN2
DRYDALRACIGDTLC	UBA6	441	A0AVT1
KCRLCSYATLREESL	ZNF516	201	Q92618
RCLFELKYVAEALEC	WDTC1	441	Q8N5D0
LCERIRKVYGDLECE	ZFAT	731	Q9P243
AQGLAEKIRACCYLE	RHOV	171	Q96L33
AESVLYRLCCDASLK	TMEM232	141	C9JQI7
LSCKLEREFRCVELA	WDHD1	771	O75717
AKEYCRERPDCLDTV	VPS18	411	Q9P253
AIERCCTRYKIISLD	XRN1	621	Q8IZH2
LDCLNRDNYIRSCKL	TLE3	526	Q04726
IEFRECREEILKFLC	PRKDC	76	P78527
IDYDCRDVKEELLFC	ZMYM6	931	O95789
LRRSLDDKPYKCTEC	ZNF22	46	P17026
CKVAEDDFRLCLRIN	TRPV3	721	Q8NET8
LCDFCLDDTRRVKAV	TRIM16	76	O95361
CLCSRAFVEDRKLYN	TGS1	26	Q96RS0
EREKLDGLYECILCA	SDHB	176	P21912
YCNREIRDCPKITLE	ZNF185	631	O15231
FDDYIACCVKLRALT	SRI	156	P30626
LKRSLLCRDSAYDSD	SPATA6	411	Q9NWH7
LLEEYGCCKELASRL	PLK1	566	P53350
LRRYCVFSHEELICK	KDM5C	636	P41229
LDPDSCRKAILCYSE	MUC12	5271	Q9UKN1
IERIELCAYSCEDRS	N4BP2	591	Q86UW6