Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	CCR5 chemokine receptor binding	CCL4L1 JAK1 CCL4	3.57e-05	13	102	3	GO:0031730
GeneOntologyMolecularFunction	3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity	SRD5A3 SRD5A1	7.73e-05	3	102	2	GO:0047751
GeneOntologyMolecularFunction	3-oxo-5-alpha-steroid 4-dehydrogenase activity	SRD5A3 SRD5A1	7.73e-05	3	102	2	GO:0003865
GeneOntologyMolecularFunction	steroid dehydrogenase activity, acting on the CH-CH group of donors	SRD5A3 SRD5A1	1.54e-04	4	102	2	GO:0033765
GeneOntologyMolecularFunction	CCR chemokine receptor binding	CCL4L1 JAK1 CCL4 CCL21	1.92e-04	56	102	4	GO:0048020
GeneOntologyMolecularFunction	enone reductase activity	SRD5A3 SRD5A1	7.09e-04	8	102	2	GO:0035671
GeneOntologyMolecularFunction	chemokine receptor binding	CCL4L1 JAK1 CCL4 CCL21	7.90e-04	81	102	4	GO:0042379
GeneOntologyCellularComponent	GLI-SUFU complex	GLI1 GLI3	1.41e-04	4	102	2	GO:1990788
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	EHBP1 MAGI1 VIPR1 HIVEP2 SRD5A3 SPATA6 RALGAPB FRMPD1 TTYH3 DENND2B BICD1 NFATC1 TLE3 LPP OSBPL5 KATNIP ZRANB1 SMURF2 CRAMP1 GLIS1 MTARC1	3.26e-09	1489	105	21	28611215
Pubmed	Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1).	GLIS3 GLI1 GLIS1	2.67e-08	3	105	3	18263616
Pubmed	Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2.	CCL4L1 CCL4 NOS2	5.31e-07	6	105	3	24486487
Pubmed	RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.	GLI1 GLI3 GLIS1	5.31e-07	6	105	3	33895473
Pubmed	A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.	GLI1 GLI3 GLIS1	5.31e-07	6	105	3	12385751
Pubmed	CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.	GLIS3 GLI1 GLI3	3.16e-06	10	105	3	18298960
Pubmed	Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci.	CCL4L1 CCL4 NOS2	3.16e-06	10	105	3	11756344
Pubmed	Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain.	CCL4L1 JAK1 TLR2 CCL4	5.95e-06	39	105	4	27318131
Pubmed	Hepatic serum amyloid A1 aggravates T cell-mediated hepatitis by inducing chemokines via Toll-like receptor 2 in mice.	CCL4L1 TLR2 CCL4	7.48e-06	13	105	3	25847238
Pubmed	Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid.	NFATC1 GLI1	9.03e-06	2	105	2	26601952
Pubmed	Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3.	GLI1 GLI3	9.03e-06	2	105	2	18559511
Pubmed	Molecular cloning and expression pattern of a Cubitus interruptus homologue from the mulberry silkworm Bombyx mori.	GLI1 GLI3	9.03e-06	2	105	2	12351188
Pubmed	A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.	GLI1 GLI3	9.03e-06	2	105	2	21921029
Pubmed	Palmar and plantar pads and flexion creases of genetic polydactyly mice (Pdn).	GLI1 GLI3	9.03e-06	2	105	2	9918099
Pubmed	Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves.	GLI1 GLI3	9.03e-06	2	105	2	32114096
Pubmed	Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.	GLI1 GLI3	9.03e-06	2	105	2	10693759
Pubmed	A novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy.	AHI1 DNM2	9.03e-06	2	105	2	28366933
Pubmed	Identification of Glis1, a novel Gli-related, Kruppel-like zinc finger protein containing transactivation and repressor functions.	GLIS3 GLIS1	9.03e-06	2	105	2	12042312
Pubmed	Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis.	TAGAP LPP	9.03e-06	2	105	2	28208589
Pubmed	gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development.	GLI1 GLI3	9.03e-06	2	105	2	8364225
Pubmed	[Significance of lipopolysaccharides, toll-like receptor and inducible nitric oxide synthase in hepatopulmonary syndrome].	TLR2 NOS2	9.03e-06	2	105	2	19953876
Pubmed	Expression of the GLI family genes is associated with tumor progression in advanced lung adenocarcinoma.	GLI1 GLI3	9.03e-06	2	105	2	25103784
Pubmed	Lysosomal trafficking regulator restricts intracellular growth of Coxiella burnetii by inhibiting the expansion of Coxiella-containing vacuole and upregulating nos2 expression.	LYST NOS2	9.03e-06	2	105	2	38282619
Pubmed	TLR2 signal influences the iNOS/NO responses and worm development in C57BL/6J mice infected with Clonorchis sinensis.	TLR2 NOS2	9.03e-06	2	105	2	28784165
Pubmed	TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappaB.	NFATC1 TLR2	9.03e-06	2	105	2	21566133
Pubmed	Global gene expression patterns and induction of innate immune response in human laryngeal epithelial cells in response to Acinetobacter baumannii outer membrane protein A.	TLR2 NOS2	9.03e-06	2	105	2	18625015
Pubmed	Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors.	AHI1 DNM2	9.03e-06	2	105	2	22623184
Pubmed	Cloning and expression of a lymphocyte activation gene (LAG-1).	CCL4L1 CCL4	9.03e-06	2	105	2	2247088
Pubmed	Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer.	SRD5A3 SRD5A1	9.03e-06	2	105	2	17986282
Pubmed	A novel group of multi-GAP-domain proteins.	TAGAP ARHGAP20	9.03e-06	2	105	2	18363199
Pubmed	Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits.	TBX4 GLI1 GLI3	9.50e-06	14	105	3	32268095
Pubmed	KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.	PDGFRB GLI1 GLI3	1.18e-05	15	105	3	26439735
Pubmed	Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.	TBX4 GLI1 GLI3	1.76e-05	17	105	3	24726282
Pubmed	Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease.	TBX4 PDGFRB GLI1 GLI3	1.90e-05	52	105	4	30389913
Pubmed	Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis.	CCL4L1 CCL4 NOS2	2.50e-05	19	105	3	10438970
Pubmed	Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development.	PDGFRB GLI1 GLI3	2.50e-05	19	105	3	24886827
Pubmed	Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.	GLI1 GLI3	2.70e-05	3	105	2	26010061
Pubmed	A Novel Resolution of Diabetes: C-C Chemokine Motif Ligand 4 Is a Common Target in Different Types of Diabetes by Protecting Pancreatic Islet Cell and Modulating Inflammation.	CCL4L1 CCL4	2.70e-05	3	105	2	33968046
Pubmed	Critical role of CCL4 in eosinophil recruitment into the airway.	CCL4L1 CCL4	2.70e-05	3	105	2	30854716
Pubmed	Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients.	CCL4L1 CCL4	2.70e-05	3	105	2	15843566
Pubmed	Identification, cloning, and characterization of an immune activation gene.	CCL4L1 CCL4	2.70e-05	3	105	2	2462251
Pubmed	The Genomic Alterations of 5α-Reductases and Their Inhibitor Finasteride's Effect in Bladder Cancer.	SRD5A3 SRD5A1	2.70e-05	3	105	2	29187470
Pubmed	Brachyphalangy, an allele of extra-toes in the mouse.	GLI1 GLI3	2.70e-05	3	105	2	5806166
Pubmed	An ATF/CREB-binding site is essential for cell-specific and inducible transcription of the murine MIP-1 beta cytokine gene.	CCL4L1 CCL4	2.70e-05	3	105	2	7835696
Pubmed	Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes.	CCL4L1 CCL4	2.70e-05	3	105	2	2568930
Pubmed	Characterization of 5α-reductase activity and isoenzymes in human abdominal adipose tissues.	SRD5A3 SRD5A1	2.70e-05	3	105	2	26855069
Pubmed	Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.	MAGI1 LY75	2.70e-05	3	105	2	25557950
Pubmed	Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.	GLI1 GLI3	2.70e-05	3	105	2	28965847
Pubmed	Gli family members are differentially expressed during the mitotic phase of spermatogenesis.	GLI1 GLI3	2.70e-05	3	105	2	9178901
Pubmed	Bone marrow-derived monocyte lineage cells recruited by MIP-1β promote physiological revascularization in mouse model of oxygen-induced retinopathy.	CCL4L1 CCL4	2.70e-05	3	105	2	21912378
Pubmed	Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.	GLI1 GLI3	2.70e-05	3	105	2	8378770
Pubmed	YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.	PDGFRB JAK1	2.70e-05	3	105	2	12551917
Pubmed	Proinflammatory MG-63 cells response infection with Enterococcus faecalis cps2 evaluated by the expression of TLR-2, IL-1β, and iNOS mRNA.	TLR2 NOS2	2.70e-05	3	105	2	28800779
Pubmed	Expression of TLR 2, TLR 4 and iNOS in cervical monocytes of Chlamydia trachomatis-infected women and their role in host immune response.	TLR2 NOS2	2.70e-05	3	105	2	21883620
Pubmed	Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.	GLI1 GLI3	2.70e-05	3	105	2	24311597
Pubmed	Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.	GLI1 GLI3	2.70e-05	3	105	2	10075717
Pubmed	Inhibition of macrophage inflammatory protein-1β improves endothelial progenitor cell function and ischemia-induced angiogenesis in diabetes.	CCL4L1 CCL4	2.70e-05	3	105	2	29987448
Pubmed	The gene encoding the Act-2 cytokine. Genomic structure, HTLV-I/Tax responsiveness of 5' upstream sequences, and chromosomal localization.	CCL4L1 CCL4	2.70e-05	3	105	2	1894635
Pubmed	Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.	GLIS3 GLI1	2.70e-05	3	105	2	21543335
Pubmed	Nitric oxide is involved in Mycobacterium bovis bacillus Calmette-Guérin-activated Jagged1 and Notch1 signaling.	TLR2 NOS2	2.70e-05	3	105	2	20147635
Pubmed	A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.	GLI1 GLI3	2.70e-05	3	105	2	8387379
Pubmed	Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.	GLI1 GLI3	2.70e-05	3	105	2	16571352
Pubmed	The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway.	GLI1 GLI3	2.70e-05	3	105	2	29722127
Pubmed	High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR.	CCL4L1 CCL4	2.70e-05	3	105	2	8134838
Pubmed	Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development.	GLI1 GLI3	2.70e-05	3	105	2	22178118
Pubmed	GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions.	GLIS3 GLIS1	2.70e-05	3	105	2	14500813
Pubmed	Gene of the month: GLIS1-3.	GLIS3 GLIS1	2.70e-05	3	105	2	32699115
Pubmed	The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2 and LAG-1.	CCL4L1 CCL4	2.70e-05	3	105	2	11685466
Pubmed	Expression of Toll-like receptors 2 and 4 on human intestinal lymphatic vessels.	TLR2 CCL21	2.70e-05	3	105	2	14709406
Pubmed	Involvement of CD4+ and CD8+ T-lymphocytes in the modulation of nociceptive processing evoked by CCL4 in mice.	CCL4L1 CCL4	2.70e-05	3	105	2	34999112
Pubmed	CCL4 protects from type 1 diabetes by altering islet beta-cell-targeted inflammatory responses.	CCL4L1 CCL4	2.70e-05	3	105	2	17327452
Pubmed	Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells.	TLR2 NOS2	2.70e-05	3	105	2	17855767
Pubmed	Independent expression of the two paralogous CCL4 genes in monocytes and B lymphocytes.	CCL4L1 CCL4	2.70e-05	3	105	2	14673550
Pubmed	DNA methylation signatures and coagulation factors in the peripheral blood leucocytes of epithelial ovarian cancer.	LYST NFATC1	2.70e-05	3	105	2	28637314
Pubmed	Twist plays an essential role in FGF and SHH signal transduction during mouse limb development.	TBX4 GLI1 GLI3	3.42e-05	21	105	3	12142027
Pubmed	Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain.	GLI1 GLI3 PITX3	3.95e-05	22	105	3	26542012
Pubmed	IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations.	CCL4L1 CCL4 NOS2	3.95e-05	22	105	3	9177770
Pubmed	ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.	TBX4 PDGFRB GLI1	4.53e-05	23	105	3	26027930
Pubmed	Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region.	GLI1 GLI3	5.40e-05	4	105	2	9027508
Pubmed	MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity.	TLR2 NOS2	5.40e-05	4	105	2	12244184
Pubmed	Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina.	GLI1 GLI3	5.40e-05	4	105	2	22281533
Pubmed	IL-1R/TLR2 through MyD88 Divergently Modulates Osteoclastogenesis through Regulation of Nuclear Factor of Activated T Cells c1 (NFATc1) and B Lymphocyte-induced Maturation Protein-1 (Blimp1).	NFATC1 TLR2	5.40e-05	4	105	2	26483549
Pubmed	A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice.	ZAP70 TLR2	5.40e-05	4	105	2	15781585
Pubmed	Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.	GLI1 GLI3	5.40e-05	4	105	2	27793025
Pubmed	A novel polypeptide secreted by activated human T lymphocytes.	CCL4L1 CCL4	5.40e-05	4	105	2	2809212
Pubmed	Expression profile of Gli family members and Shh in normal and mutant mouse limb development.	GLI1 GLI3	5.40e-05	4	105	2	9438426
Pubmed	Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins.	PDGFRB JAK1	5.40e-05	4	105	2	8657151
Pubmed	Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development.	GLI1 GLI3	5.40e-05	4	105	2	8150204
Pubmed	Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis.	CCL4L1 CCL4	5.40e-05	4	105	2	27177471
Pubmed	Macrophage inflammatory protein-1β as a novel therapeutic target for renal protection in diabetic kidney disease.	CCL4L1 CCL4	5.40e-05	4	105	2	36863097
Pubmed	CCR7 Is Important for Mesangial Cell Physiology and Repair.	PDGFRB CCL21	5.40e-05	4	105	2	29077526
Pubmed	Alternative modes of binding of proteins with tandem SH2 domains.	PDGFRB ZAP70	5.40e-05	4	105	2	10752619
Pubmed	Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages.	CCL4L1 CCL4	5.40e-05	4	105	2	16982098
Pubmed	Alternatively-Activated Macrophages Upregulate Mesothelial Expression of P-Selectin to Enhance Adhesion of Ovarian Cancer Cells.	CCL4L1 CCL4	5.40e-05	4	105	2	29739756
Pubmed	A novel role of Yin-Yang-1 in pulmonary tuberculosis through the regulation of the chemokine CCL4.	CCL4L1 CCL4	5.40e-05	4	105	2	26786659
Pubmed	Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.	GLI1 GLI3	5.40e-05	4	105	2	10531011
Pubmed	Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.	CCL4L1 CCL4	5.40e-05	4	105	2	2521882
Pubmed	Decreased IgG production but increased MIP-1beta expression in collagen-induced arthritis in C-C chemokine receptor 5-deficient mice.	CCL4L1 CCL4	5.40e-05	4	105	2	15967376
Pubmed	Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity.	CCL4L1 CCL4	5.40e-05	4	105	2	12070155
Pubmed	Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.	GLI1 GLI3	5.40e-05	4	105	2	9006072
Coexpression	LAKE_ADULT_KIDNEY_C11_THIN_ASCENDING_LIMB	MAGI1 AHI1 HIVEP2 GLIS3 LPP DNAH5 WWC1	5.48e-06	169	105	7	M39230
Coexpression	GSE15930_NAIVE_VS_48H_IN_VITRO_STIM_IL12_CD8_TCELL_UP	VIPR1 IL16 SPATA6 LYST DENND2B OSBPL5 ZRANB1	1.59e-05	199	105	7	M3599
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP	PDGFRB PRELP TLR2 TMPO LY75 NNMT PHLDB2	2.85e-05	218	105	7	M1099
Coexpression	HORIUCHI_WTAP_TARGETS_UP	HIVEP2 GLIS3 KCNJ2 TPP1 LPP PITPNM3 LY75 SMCR8	3.53e-05	309	105	8	M1973
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDE3A IL16 PDGFRB PRELP GLI3 KIAA1755 NNMT PHLDB2	1.94e-08	193	105	8	261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D122\|Adult / Lineage, Cell type, age group and donor	TBX4 PDGFRB PRELP GLI1 GLI3 KIAA1755 ANO3	9.83e-08	158	105	7	410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDE3A IL16 PDGFRB GLI3 KIAA1755 NNMT PHLDB2	4.10e-07	195	105	7	ff0aa455e9844a6d7ae57ff59fb6cea825cf1fc2
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PDGFRB DENND2B PRELP LPP SLC38A11 PHLDB2	4.24e-07	196	105	7	184104cbea0461dd2757668ab9755948ac7b585a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PDGFRB DENND2B PRELP LPP SLC38A11 PHLDB2	4.24e-07	196	105	7	bebb20dc210576101c317011e3afb59798f5d255
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PDGFRB DENND2B PRELP LPP SLC38A11 PHLDB2	4.24e-07	196	105	7	8114e98923096c54b6834f21550c3061bab6773d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB DENND2B NFATC1 PEAK1 NNMT ANO3	4.39e-07	197	105	7	9b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	IL16 TBX4 PDGFRB PRELP GLI3 ARHGAP20 NNMT	4.54e-07	198	105	7	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TBX4 PDGFRB PRELP LPP PEAK1 ANO3	3.72e-06	175	105	6	1799a7be623dc3bf53ba580a7c47d2619969d708
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GLIS3 P2RX2 KCNJ2 CCL21 NNMT NOS2	3.97e-06	177	105	6	76f5df101c693e5fa61554244d877fc8169ee66f
ToppCell	Children_(3_yrs)-Mesenchymal-airway_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TBX4 ADAMTS6 PRELP LTBP3 NNMT ANO3	3.97e-06	177	105	6	b59967219f7d874805768e247c0eb2bc4d4420c8
ToppCell	wk_20-22-Hematologic_Lymphocytic-NK-Activated_NK\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CCL4L1 IL16 TAGAP LYST ZAP70 JAK1	4.10e-06	178	105	6	5b19dbf9dc8e41e6a16a2abbb798d49ee8d8653f
ToppCell	COVID-19-Fibroblasts-Adventitial_FB\|COVID-19 / group, cell type (main and fine annotations)	PDGFRB GLIS3 GLI3 KIAA1755 NNMT PHLDB2	5.12e-06	185	105	6	a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB DENND2B GLI3 ARHGAP20 ANO3	6.14e-06	191	105	6	a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PDGFRB PRELP LPP SLC38A11 PHLDB2	6.14e-06	191	105	6	cb75e6c36dbe2e091e407d691c063ec7c4fd5f90
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PDGFRB PRELP LPP SLC38A11 PHLDB2	6.14e-06	191	105	6	b2cffea7860dd590b505ee0ebd51aa1978cb5e64
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB DENND2B GLI3 ARHGAP20 ANO3	6.14e-06	191	105	6	8f6d592edc32fdb901af30501d4360512334e8c2
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB PRELP GLI3 KIAA1755 ARHGAP20 NNMT	6.33e-06	192	105	6	8937a59f6bbe07f671bdabbd3707dc9c17a14cd9
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB PRELP GLI3 KIAA1755 ARHGAP20 NNMT	6.33e-06	192	105	6	e4a7f2673f801b008ca67291db2fb2b9fd2955b8
ToppCell	facs-Pancreas-Exocrine-3m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDGFRB PRELP GLI3 KIAA1755 ARHGAP20 NNMT	6.33e-06	192	105	6	ac1477433704573f95111eee6263b93668d2845e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PDGFRB PRELP LPP SLC38A11 PHLDB2	6.33e-06	192	105	6	e5117cdb8af220f60bd1410262078c0306667b4a
ToppCell	LA\|World / Chamber and Cluster_Paper	EHBP1 IL16 GLIS3 BICD1 GLI3 NNMT	6.52e-06	193	105	6	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDE3A IL16 PDGFRB GLI3 KIAA1755 NNMT	6.52e-06	193	105	6	9ab47b360bee1d4f1092c2269e58acebe9584021
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PDGFRB PRELP LPP SLC38A11 PHLDB2	6.72e-06	194	105	6	bf34737ae2dc218f890fbb9201c308b324415749
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PDGFRB PRELP LPP SLC38A11 PHLDB2	6.72e-06	194	105	6	b35e33439b6d3b5d69147e617224d2c8fd056223
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PDGFRB PRELP LPP SLC38A11 PHLDB2	6.72e-06	194	105	6	4ebed7a6731b88c8359860072cbeba355a7e90ac
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDGFRB P2RX2 PRELP KIAA1755 NNMT PHLDB2	6.92e-06	195	105	6	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	COVID-19_Severe-NK\|World / disease group, cell group and cell class	PDGFRB ZAP70 JAK1 OSBPL5 CCL4 CTPS1	7.12e-06	196	105	6	f46ca7cc2d8407d0dcaa77c4b16a2c1f2a23734d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2B BICD1 NFATC1 KIAA1755 PEAK1 ANO3	7.33e-06	197	105	6	85a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DENND2B BICD1 NFATC1 KIAA1755 PEAK1 ANO3	7.33e-06	197	105	6	e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCell	BL\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TAGAP LYST PHF20L1 KCNJ2 TLR2 CCL4	7.33e-06	197	105	6	1acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCell	COVID-19-Fibroblasts\|COVID-19 / group, cell type (main and fine annotations)	PDE3A PDGFRB GLIS3 GLI3 NNMT PHLDB2	7.33e-06	197	105	6	fb847f2277609c31fffcdf49517243ce0684facf
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ZAP70 JAK1 OSBPL5 CCL4 PHLDB2 B4GALT4	7.55e-06	198	105	6	326e97bdc27cc3440f5488c2519446580cdc9d51
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GLIS3 DENND2B NFATC1 PEAK1 NNMT ANO3	7.55e-06	198	105	6	a860246bcea847249a78fd2e86ed8e04371060db
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ZAP70 JAK1 OSBPL5 CCL4 PHLDB2 B4GALT4	7.55e-06	198	105	6	2fdb92b198ba24e326e90479fd024400d956fb32
ToppCell	Fibroblasts-HLA-DRA_high_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	PDGFRB GLIS3 DENND2B GLI3 KIAA1755 NNMT	7.55e-06	198	105	6	e8c0fbf306fae13e97caa294d7c99a564bd97130
ToppCell	Control_saline-Hematopoietic_Lymphocytic-Lymphocytic_NK/T-iNKT-MAIT\|Control_saline / Treatment groups by lineage, cell group, cell type	IL16 TAGAP LYST ZAP70 JAK1 ACOT11	7.77e-06	199	105	6	2d7ebb9642f6fe0afd5e3fdc711ded54b73acd11
ToppCell	Tracheal-10x5prime-Stromal-Myofibroblastic\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A PDGFRB LPP SLC38A11 CCL21 NNMT	7.77e-06	199	105	6	0a145172787f40d0fdaf21188d539ffaf7ece3e4
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	AHI1 PLA2G4B LTBP3 WWC1 PHLDB2 DNM2	7.99e-06	200	105	6	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	Tracheal-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PDE3A IL16 PDGFRB PRELP NNMT PHLDB2	7.99e-06	200	105	6	c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCell	cellseq-Mesenchymal-Myocytic-Myocytic_2-SCMF\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TBX4 PDGFRB PRELP GLI1 NNMT ANO3	7.99e-06	200	105	6	b441b3771fb7d9ee7b7a104afc35e466aace2da2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB ADAMTS6 KCNJ2 ANO3	2.84e-05	150	105	5	8645b9c7f9511ed6cc9afe04440c2873a3094150
ToppCell	Hippocampus-Macroglia-CSF_related\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DRC7 GAS2L2 DNAAF1 MTARC1 SLC44A3	3.03e-05	152	105	5	c2b6cc41546cbd46b9ea5d28a7c66f6330a27df2
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PDE3A PDGFRB PRELP SLC38A11 PHLDB2	3.65e-05	158	105	5	08806240228c5b780f5aef92ce2c278ae4d797cc
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PDE3A PDGFRB PRELP SLC38A11 PHLDB2	3.65e-05	158	105	5	496b6988f7b3439968351840ae22f56ffa1643f1
ToppCell	frontal_cortex-Non-neuronal-smooth_muscle_cell-SMC\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PDE3A PDGFRB PRELP SLC38A11 PHLDB2	3.65e-05	158	105	5	5b3d30f92b619f14a7b48502170000fa5783358a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDGFRB GLI1 KIAA1755 ANO3 BRF2	4.11e-05	162	105	5	bfaeff19bb56598fdc8c82be71d51787cf13928f
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B2\|367C / Donor, Lineage, Cell class and subclass (all cells)	TAGAP FRMPD1 ZAP70 PKP1 CCL4	4.11e-05	162	105	5	59c0dcb5b51c1803660aeec51b60deceeeaeea66
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell-SMC\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PDE3A PDGFRB PRELP SLC38A11 PHLDB2	4.36e-05	164	105	5	9eed945e9b0c1ee5fc62724ac2bbbed4267b0678
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DRC7 PKP1 DNAAF1 DNAH5 ANO3	4.36e-05	164	105	5	e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PDE3A PDGFRB PRELP SLC38A11 PHLDB2	4.36e-05	164	105	5	f510f20e37e31b486cdd0e3f597ce4ff00877c5d
ToppCell	E17.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IL16 TAGAP PGAP6 TLR2 CCL21	4.36e-05	164	105	5	4e9de41ea10ce3233c09e144bfc0453c0ae79fd3
ToppCell	primary_visual_cortex-Non-neuronal-smooth_muscle_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PDE3A PDGFRB PRELP SLC38A11 PHLDB2	4.36e-05	164	105	5	5c932a462cbf81d029c8d11ec3aea3191529527b
ToppCell	E17.5-Endothelial-lymphatic_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	IL16 TAGAP PGAP6 TLR2 CCL21	4.36e-05	164	105	5	6f4914b0ac282b4b9f6111930a82515178c1bc80
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB MYO1H ADAMTS6 ANO3	4.48e-05	165	105	5	e2aebb2fe197151e019371b8960f76f0c2386f08
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB MYO1H ADAMTS6 ANO3	4.48e-05	165	105	5	b087771499aeb31cc4a338d2d0a9392a4ec1ac45
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB MYO1H ADAMTS6 ANO3	4.48e-05	165	105	5	d8f8b088fd28a6b9dbd6b51bcaee42000e963321
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	FAM43B P2RX2 PRELP GLI1 GLI3	4.61e-05	166	105	5	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	FAM43B P2RX2 PRELP GLI1 GLI3	4.61e-05	166	105	5	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	Adult-Mesenchymal-myofibroblast_cell\|Adult / Lineage, Cell type, age group and donor	TBX4 PDGFRB PRELP GLI1 ANO3	4.75e-05	167	105	5	d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CELF4 ADAMTS6 PKP1 ANO3 PHLDB2	4.88e-05	168	105	5	1d58731a481ecac84c15affa84f8041dd67d944c
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ADAMTS6 PKP1 SLC38A11 ANO3 PHLDB2	5.17e-05	170	105	5	49fc45d8a5c3ad89d1649fa46d7a285891379392
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB ADAMTS6 KCNJ2 MTARC1	5.17e-05	170	105	5	99dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AHI1 TAGAP COPG2 ZAP70 LY75	5.17e-05	170	105	5	3ad9f950b87ee98f025ab9b4a8ed551e6a9b4764
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB ADAMTS6 KCNJ2 MTARC1	5.17e-05	170	105	5	3a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB ADAMTS6 KCNJ2 MTARC1	5.17e-05	170	105	5	cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_D\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MYO1H FRMPD1 CCL4 PEAK1 MTARC1	5.31e-05	171	105	5	943fbca8a6ac04052a2a85aca7b21a3461cd96f7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A IL16 KIAA1755 ARHGAP20 NNMT	5.31e-05	171	105	5	5d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCell	Pericytes-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	TBX4 PDGFRB PRELP GLI1 SLC38A11	5.31e-05	171	105	5	bbc8d9fc83d37c9250345b1e76776610799de9ae
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB ADAMTS6 LPP ANO3	5.61e-05	173	105	5	fc2602b2ce051cd4c33957d7e3d041ff8a529883
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB ADAMTS6 LPP ANO3	5.61e-05	173	105	5	901b8e6909c1f3849906fad9cee17b8f0bab050d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB PRELP KIAA1755 ANO3	5.93e-05	175	105	5	795a6564d5a75ffd35d39f5274b9e8d28708bbc8
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 GLIS3 NFATC1 DNAH5 GLIS1	5.93e-05	175	105	5	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GLIS3 LPP SLC38A11 ANO3 PHLDB2	6.09e-05	176	105	5	40993c41c1017b53039a337174fc56632b278609
ToppCell	wk_15-18-Hematologic_Lymphocytic-NK-Activated_NK\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CCL4L1 IL16 TAGAP LYST ZAP70	6.09e-05	176	105	5	6802ed40eb0f91674d4f0120a3d4888c8a2e9612
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 GAS2L2 ALPK3 DNAAF1 DNAH5	6.26e-05	177	105	5	ae01c19403a09f7ba5e4beafdfcd1b8eebdadcb7
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AHI1 ZAP70 NFATC1 ADAMTS6 CCL4	6.26e-05	177	105	5	b8de0fc92691a6d6759c743195b11edd2d63f265
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB DENND2B LPP SLC38A11	6.26e-05	177	105	5	a8625d14682183cf77cb51eaf11bc15a3528f586
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB DENND2B LPP SLC38A11	6.26e-05	177	105	5	3645e2f4a48283f290f85c49c3e79e3f58ac9aa6
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 GAS2L2 ALPK3 DNAAF1 DNAH5	6.26e-05	177	105	5	bd3d07bdef6e903995d4bbfb6ff3a5e1d9fb70cc
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	HIVEP2 PDGFRB RALGAPB GLI1 LY75	6.43e-05	178	105	5	edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCell	21-Trachea-Immune-Hematopoietic,_Natural_Killer_Cell\|Trachea / Age, Tissue, Lineage and Cell class	CCL4L1 TAGAP ZAP70 JAK1 CCL4	6.43e-05	178	105	5	d2e1f6b7933b7da2682393e5ff5e03cdd8f64761
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAGI1 P2RX2 CCL21 NNMT NOS2	6.60e-05	179	105	5	1c0c0647a111f691dae55f4ed8c51006059ce020
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCL4L1 TLR2 LPP PITPNM3 ARHGAP20	6.60e-05	179	105	5	87f608b137aae34572b150492a83a3a127cff40b
ToppCell	LA-01._Fibroblast_I\|LA / Chamber and Cluster_Paper	SPATA6 GLIS3 PRELP KIAA1755 NNMT	6.60e-05	179	105	5	dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCell	ASK440-Immune-NK_cell\|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq	IL16 TAGAP ZAP70 OSBPL5 CCL4	6.77e-05	180	105	5	340e750356d23fe9af0e8f298f8a273ff426052f
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYST ZAP70 JAK1 PEAK1 LY75	7.14e-05	182	105	5	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYST ZAP70 JAK1 PEAK1 LY75	7.14e-05	182	105	5	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	pdx-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	BRPF3 TBX4 HIVEP2 ZAP70 TLR2	7.14e-05	182	105	5	7b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PDGFRB ADAMTS6 OSBPL5 CCL4 B4GALT4	7.32e-05	183	105	5	983ca1342ddd365e1f1df32a456394b002b10e41
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAGI1 GLIS3 NFATC1 CCL21 NNMT	7.32e-05	183	105	5	764ea07621f77fbd13a877aed5806ae2b3dfb43e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB DENND2B SLC38A11 ANO3	7.32e-05	183	105	5	667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PRELP LPP SLC38A11 PHLDB2	7.51e-05	184	105	5	89ae8bf1a6c2d355d279d23a5e24a08d9ec2334e
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3A PDGFRB PRELP ARHGAP20 ANO3	7.51e-05	184	105	5	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A PRELP LPP SLC38A11 PHLDB2	7.51e-05	184	105	5	34c84ac9a32eaf96f45b79485119cad65905817d
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	TBX4 DENND2B ADAMTS6 LPP NNMT	7.71e-05	185	105	5	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DRC7 TAGAP ALPK3 DNAH5 WWC1	7.71e-05	185	105	5	05bc89a566b0db90ae06506e067190a4739a0974
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D175\|Adult / Lineage, Cell type, age group and donor	MAGI1 DSCAM PEAK1 WWC1 PHLDB2	7.71e-05	185	105	5	32b4e68e551d435a732f253f6ad83408c759a642
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MAGI1 TLR2 DNAH5 WWC1 SLC44A3	7.91e-05	186	105	5	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	(0)_MSCs\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	PDGFRB DENND2B P2RX2 NNMT MTARC1	7.91e-05	186	105	5	a832c1e0035bcd559722eccf262c145deb3494c7
Disease	rhinitis (is_marker_for)	IL16 TLR2 CCL4 NOS2	1.82e-05	46	100	4	DOID:4483 (is_marker_for)
Disease	response to bevacizumab, Proteinuria	JAK1 DNAH5	1.13e-04	5	100	2	EFO_0005943, HP_0000093
Disease	anti-basement membrane glomerulonephritis (biomarker_via_orthology)	CCL4L1 CCL4 NOS2	1.43e-04	30	100	3	DOID:4780 (biomarker_via_orthology)
Disease	Mitral valve prolapse	ALPK3 LTBP3 GLIS1	2.49e-04	36	100	3	HP_0001634
Disease	vital capacity	EHBP1 PDE3A AHI1 TBX4 HIVEP2 FRMPD1 GLIS3 DHDDS ADAMTS6 GLI3 LTBP3 CCL21 SMURF2	2.77e-04	1236	100	13	EFO_0004312
Disease	Rheumatoid Arthritis	TAGAP TLE3 TLR2 TMPO CCL21	3.22e-04	174	100	5	C0003873
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI1 GLI3	4.03e-04	9	100	2	DOID:0050338 (implicated_via_orthology)
Disease	dry eye syndrome (is_marker_for)	TLR2 CCL4	5.03e-04	10	100	2	DOID:10140 (is_marker_for)
Disease	Primary Ciliary Dyskinesia	GAS2L2 DNAAF1 DNAH5	5.50e-04	47	100	3	C4551720
Disease	nucleus accumbens volume change measurement	DSCAM WWC1	6.13e-04	11	100	2	EFO_0021493
Disease	alkaline phosphatase measurement	DHDDS FAM43B DENND2B JAK1 NGRN NFATC1 GLI3 TONSL PITX3 LTBP3 MTARC1	6.57e-04	1015	100	11	EFO_0004533
Disease	prostate cancer (is_implicated_in)	IL16 SRD5A1 JAK1 TLR2	6.87e-04	117	100	4	DOID:10283 (is_implicated_in)
Disease	Mitral valve prolapse, response to surgery	ALPK3 LTBP3	7.34e-04	12	100	2	EFO_0009951, HP_0001634
Disease	stenosing tenosynovitis	ADAMTS6 LTBP3	7.34e-04	12	100	2	EFO_0010822
Disease	Disorder of eye	AHI1 DHDDS TPP1 PITX3 PITPNM3	7.91e-04	212	100	5	C0015397
Disease	lung disease (implicated_via_orthology)	TLR2 NOS2	8.66e-04	13	100	2	DOID:850 (implicated_via_orthology)
Disease	anxiety	MAGI1 CELF4 DSCAM MYO1H LTBP3	9.91e-04	223	100	5	EFO_0005230
Disease	nodular sclerosis Hodgkin lymphoma	AHI1 LPP	1.01e-03	14	100	2	EFO_0004708
Disease	Kuhnt-Junius degeneration (is_marker_for)	PDGFRB TLR2	1.01e-03	14	100	2	DOID:10873 (is_marker_for)
Disease	migraine disorder, type 2 diabetes mellitus	CELF4 DHDDS GLI3	1.12e-03	60	100	3	MONDO_0005148, MONDO_0005277
Disease	Prostatic Neoplasms	EHBP1 IL16 SRD5A1 JAK1 TPP1 PITX3 DNMT3B B4GALT4	1.19e-03	616	100	8	C0033578
Disease	Malignant neoplasm of prostate	EHBP1 IL16 SRD5A1 JAK1 TPP1 PITX3 DNMT3B B4GALT4	1.19e-03	616	100	8	C0376358
Disease	lifestyle measurement	CELF4 HIVEP2 LINC01559 WWC1 DNMT3B	1.25e-03	235	100	5	EFO_0010724
Disease	digit length ratio	GLI3 GLIS1	1.32e-03	16	100	2	EFO_0004841
Disease	pre-malignant neoplasm (biomarker_via_orthology)	GLI1 GLI3	1.50e-03	17	100	2	DOID:0060071 (biomarker_via_orthology)
Disease	Antibody Deficiency Syndrome	ZAP70 DNMT3B	1.50e-03	17	100	2	C0003257
Disease	obesity (biomarker_via_orthology)	CCL4L1 PDE3A SRD5A1 CCL4	1.60e-03	147	100	4	DOID:9970 (biomarker_via_orthology)
Disease	atrial fibrillation	NFATC1 TLE3 PITX3 KIAA1755 CRAMP1 PHLDB2	1.68e-03	371	100	6	EFO_0000275
Disease	sinusitis (is_marker_for)	TLR2 CCL4	1.68e-03	18	100	2	DOID:0050127 (is_marker_for)
Disease	autism spectrum disorder (implicated_via_orthology)	DSCAM PDGFRB DENR PKP1	1.81e-03	152	100	4	DOID:0060041 (implicated_via_orthology)
Disease	primary ciliary dyskinesia (implicated_via_orthology)	GAS2L2 DNAH5	1.87e-03	19	100	2	DOID:9562 (implicated_via_orthology)
Disease	p-tau measurement	GLIS3 NFATC1 ANO3	1.90e-03	72	100	3	EFO_0004763
Disease	Joubert syndrome 1	AHI1 KATNIP	2.29e-03	21	100	2	C4551568
Disease	Bronchiectasis	DNAAF1 DNAH5	2.51e-03	22	100	2	C0006267
Disease	otosclerosis	ALPK3 LTBP3 PEAK1	2.66e-03	81	100	3	EFO_0004213
Disease	Immunologic Deficiency Syndromes	ZAP70 DNMT3B	2.75e-03	23	100	2	C0021051
Disease	FEV/FEC ratio	PDE3A HIVEP2 GLIS3 DENND2B NFATC1 LTBP3 ARHGAP20 KIF13A DNAH5 SMURF2 PHLDB2	2.98e-03	1228	100	11	EFO_0004713

Protein segments in the cluster

Peptide	Gene	Start	Entry
RSYRKQEPSLGCSIP	CCL21	46	O00585
KRQFSPSLCDQSRPR	BICD1	856	Q96G01
DSATSDYCPAPKRLK	DNMT3B	386	Q9UBC3
KVELDNCPSVSPYLR	B4GALT4	71	O60513
ITSRDSPVYPKCLLD	AHI1	326	Q8N157
PRSCDPGLIDSLKNY	ALPK3	1151	Q96L96
VPSLTERPCYDSKAA	ANKRD40CL	96	Q53H64
ALEETRYRLACPEPS	DGKQ	656	P52824
LASRRKPCDNGDPYV	ACOT11	491	Q8WXI4
NAEGRRSPSPYSLKC	BRPF3	11	Q9ULD4
LECPNSSSEKRYFPE	DHX32	6	Q7L7V1
PQLPSSCYSVDRGKR	DENND2B	301	P78524
KISSYCRSQPPARLI	DCUN1D5	26	Q9BTE7
DLRARPSSCQPSRSY	ARMC12	321	Q5T9G4
RKRYRSCNTDPCPLG	ADAMTS6	601	Q9UKP5
KPSRRSLPCLAQSYA	ANO3	31	Q9BYT9
YESRCRPVTPSCKEL	JAK1	806	P23458
KTYEVPNTPLCSARD	KCNJ2	346	P63252
DKRLPPCSLSQALTY	NOS2	816	P35228
IPGCTKRYTDPSSLR	GLI3	611	P10071
EQRRRPYKECSTDLS	MAGI1	1476	Q96QZ7
LETLKSYRQCDPSER	MTARC1	291	Q5VT66
RQLPSLACKYPVSSR	TMPO	511	P42166
PRELQKYSSDSESPR	NGRN	231	Q9NPE2
DPRDRYTKPLTFADC	WWC1	36	Q8IX03
ACTKPESSEERPYNL	KIAA1755	336	Q5JYT7
RPLSATRKTLCEAEY	KATNIP	321	O60303
NAKCAYRPPPSERSR	FAM43B	241	Q6ZT52
PPSDLYGDLKSRRNS	CCDC120	266	Q96HB5
PTACCFSYTARKLPR	CCL4	31	P13236
CRRQDSPSPDFYKQS	PCDHGC5	731	Q9Y5F6
LREPLRKASACSTYA	PDE3A	646	Q14432
NDCYKRSLERKLPPS	PEAK1	181	Q9H792
PDLPTYCRALRNLGS	NNMT	171	P40261
KKSAAPTDRQPYSLC	IL16	156	Q14005
PTDRQPYSLCSNRKS	IL16	161	Q14005
SSRPASPCNKRKYSL	NFATC1	256	O95644
PRDSLAEKPYCSQVD	KIF24	931	Q5T7B8
SILADLECSSPYKPR	LPP	126	Q93052
SRLTYSSRCPAAKEN	LY75	1521	O60449
LPGCTKRYTDPSSLR	GLI1	366	P08151
RSPFCLTNYPVTRED	PGAP6	346	Q9HCN3
RLPSKDLVTPSDCYV	PLA2G4B	21	P0C869
QCTSKLSSYPRLREE	DNM2	441	P50570
ALCSKSNPEERYETP	ETAA1	66	Q9NY74
SRPAACRAFDVPKRY	SRD5A3	61	Q9H8P0
ASECNPKYSFRRLDP	P2RX2	276	Q9UBL9
PTACCFSYTARKLPR	CCL4L1	31	Q8NHW4
PEYCSRALRQLKATP	FRMPD1	1401	Q5SYB0
QCTSSGKREERYPPE	GAS2L2	396	Q8NHY3
IPGCTKRYTDPSSLR	GLIS3	476	Q8NEA6
SLLDPLPRYLKSCQD	CRAMP1	556	Q96RY5
CSSPKPALRYAAVRT	COPG2	296	Q9UBF2
CKLANVDLPYPASSR	BRF2	251	Q9HAW0
YTIKPPRDLCSRFEQ	DRC7	246	Q8IY82
SPYCRRTKSDTEPQK	EHBP1	641	Q8NDI1
ESCPRRPDYLKGLAS	LYST	2221	Q99698
YRLKASRPPVCEDID	LTBP3	691	Q9NS15
TYLDDRPVFPKDRAC	DNAAF1	276	Q8NEP3
DPRNSAKLDADYPLR	DENR	16	O43583
RCTNPIPKSEDRRYC	INO80D	61	Q53TQ3
NYTHSPKADSLCPRL	SLC44A3	151	Q8N4M1
RRCLLRPSEPDSTGY	DCST2	486	Q5T1A1
IPGCSKRYTDPSSLR	GLIS1	326	Q8NBF1
SLLDKCLYTNRSPHP	DHDDS	186	Q86SQ9
IPSACYLKLSEEPRT	SLC38A11	321	Q08AI6
YRDPCNSSLASLRLK	PITX3	256	O75364
EPLPNAYDKSLDCFR	DNAH5	3981	Q8TE73
DKRRPPSAELYSNAL	PDGFRB	706	P09619
YVEDKAISDCRPSRP	nan	476	A6NNC1
SSATKVPPAEYRLCN	OSBPL5	66	Q9H0X9
PVASDSSYRNECPRA	PHF20L1	486	A8MW92
ACYGTLPRDSPRRNK	KIF13A	1426	Q9H1H9
KASRSEPDLYCDPRG	PKP1	151	Q13835
PSERSYRLENLKCGT	DSCAM	1431	O60469
CRALQAPDPTRDYFS	HSCB	61	Q8IWL3
RRCSEPSIDYLDSKL	ARHGAP20	701	Q9P2F6
KSSLAQPDRRYSEPS	TAGAP	366	Q8N103
QKGCRLSPRDTYSDR	CTPS1	556	P17812
PDFPSALYCDSRNLR	PRELP	81	P51888
SPDTRYRCHRKDSLP	PHLDB2	501	Q86SQ0
DLDNKTLRCPLYRGT	SMCR8	811	Q8TEV9
SSCLRQPPSQDRKLF	CELF4	141	Q9BZC1
SCSTIYLPLKRRADP	LINC01559	31	Q495D7
CPDDTECLTVPRYKR	SMURF2	356	Q9HAU4
FYSRDPDGLPCNLRK	ZAP70	86	P43403
ITKYREETPPRSRCN	SETDB2	561	Q96T68
PDIRKSDSSPYSRLA	VIPR1	326	P32241
PNKARDCSRSRSPYK	SRRM5	431	B3KS81
DLPPLTDRYRRACQS	TONSL	1011	Q96HA7
DAAPDATRRLYTSCK	TANGO6	186	Q9C0B7
CRDSYQEPPRRKATL	ZNF518A	1281	Q6AHZ1
ICRRKRLESDSYSPP	RALGAPB	1441	Q86X10
PSQEPPTKREYDQCR	UBXN1	201	Q04323
RPLPRKQSDSSTYDC	PITPNM3	336	Q9BZ71
PRIKAELTSSAPACY	TLE3	566	Q04726
RASLYPCPETPQERK	ATP6V0A1	241	Q93050
YASESAPRLRSAPNC	SRD5A1	71	P18405
EKRRPPDNSFYVRTC	UBE2W	121	Q96B02
LDLPCKRSYLEAPSS	TBX4	346	P57082
DSSPCRDNSPKRYLI	HIVEP2	2051	P31629
RAKYLATSQPRPDSS	TTYH3	506	Q9C0H2
PRKAPSRNICYDAFV	TLR2	631	O60603
EEYLSPRSCSKPRHS	SPATA6	321	Q9NWH7
ICPDSSARPRVKSSY	ZRANB1	66	Q9UGI0
SGKCSYSPEPDQRRT	TPP1	16	O14773
SYIRCIKPNDRKEPS	MYO1H	591	Q8N1T3