Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Posteriorly rotated ears	PEX1 FRMD4A HERC1 GALNT2 CDK13 SMAD2	9.09e-05	470	10	6	HP:0000358
HumanPheno	Slanting of the palpebral fissure	PEX1 HERC2 HERC1 GALNT2 AHDC1 CDK13 SMAD2	1.06e-04	739	10	7	HP:0200006
HumanPheno	Low-set ears	PEX1 FRMD4A HERC1 GALNT2 AHDC1 CDK13 SMAD2	1.28e-04	761	10	7	HP:0000369
HumanPheno	Delayed speech and language development	PEX1 FRMD4A HERC2 HERC1 GALNT2 OXR1 AHDC1 CDK13	1.60e-04	1123	10	8	HP:0000750
HumanPheno	Upslanted palpebral fissure	PEX1 HERC2 HERC1 AHDC1 CDK13	2.22e-04	333	10	5	HP:0000582
HumanPheno	Language impairment	PEX1 FRMD4A HERC2 HERC1 GALNT2 OXR1 AHDC1 CDK13	2.29e-04	1178	10	8	HP:0002463
Domain	RCC1	HERC2 HERC1	2.72e-04	20	23	2	PF00415
Domain	RCC1_3	HERC2 HERC1	3.00e-04	21	23	2	PS50012
Domain	RCC1_1	HERC2 HERC1	3.00e-04	21	23	2	PS00625
Domain	RCC1_2	HERC2 HERC1	3.00e-04	21	23	2	PS00626
Domain	-	SAFB2 SAFB	3.00e-04	21	23	2	1.10.720.30
Domain	Reg_chr_condens	HERC2 HERC1	3.30e-04	22	23	2	IPR000408
Domain	SAP	SAFB2 SAFB	3.30e-04	22	23	2	PF02037
Domain	-	HERC2 HERC1	3.30e-04	22	23	2	2.130.10.30
Domain	SAP	SAFB2 SAFB	3.61e-04	23	23	2	SM00513
Domain	RCC1/BLIP-II	HERC2 HERC1	3.61e-04	23	23	2	IPR009091
Domain	SAP	SAFB2 SAFB	4.28e-04	25	23	2	PS50800
Domain	SAP_dom	SAFB2 SAFB	4.28e-04	25	23	2	IPR003034
Domain	HECT	HERC2 HERC1	5.00e-04	27	23	2	PF00632
Domain	HECTc	HERC2 HERC1	5.00e-04	27	23	2	SM00119
Domain	HECT_dom	HERC2 HERC1	5.00e-04	27	23	2	IPR000569
Domain	HECT	HERC2 HERC1	5.00e-04	27	23	2	PS50237
Domain	Ubiquitin-rel_dom	FRMD4A NFATC2IP	2.13e-02	184	23	2	IPR029071
Pubmed	No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.	SAFB2 SAFB	5.37e-07	2	26	2	19077293
Pubmed	Low SAFB levels are associated with worse outcome in breast cancer patients.	SAFB2 SAFB	5.37e-07	2	26	2	19137425
Pubmed	Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?	SAFB2 SAFB	5.37e-07	2	26	2	14587024
Pubmed	SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells.	SAFB2 SAFB	5.37e-07	2	26	2	19901029
Pubmed	Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells.	SAFB2 SAFB	5.37e-07	2	26	2	26273616
Pubmed	Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1.	SAFB2 SAFB	5.37e-07	2	26	2	26092125
Pubmed	Scaffold attachment factor B (SAFB)1 and SAFB2 cooperatively inhibit the intranuclear mobility and function of ERα.	SAFB2 SAFB	5.37e-07	2	26	2	22566185
Pubmed	The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2.	SAFB2 SAFB	1.61e-06	3	26	2	19674106
Pubmed	SAFB1 interacts with and suppresses the transcriptional activity of p53.	SAFB2 SAFB	3.22e-06	4	26	2	21130767
Pubmed	Scaffold attachment factor SAFB1 suppresses estrogen receptor alpha-mediated transcription in part via interaction with nuclear receptor corepressor.	SAFB2 SAFB	3.22e-06	4	26	2	16195251
Pubmed	SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor.	SAFB2 SAFB	3.22e-06	4	26	2	12660241
Pubmed	The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.	HERC2 HERC1	1.13e-05	7	26	2	9949213
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	PEX1 FAM98A HERC2 GALNT2 MTCH1 SMAD2	1.62e-05	754	26	6	33060197
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	SAFB2 FAM98A HERC2 MTCH1 CDK13 NKRF	1.68e-05	759	26	6	35915203
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	SAFB2 SAFB GLG1 NKRF	3.49e-05	251	26	4	28077445
Pubmed	The DNA sequence and biology of human chromosome 19.	SAFB2 SAFB GRIN3B KLK2	5.65e-05	284	26	4	15057824
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	SAFB2 FAM98A SAFB KIF18B ALK NKRF	6.03e-05	954	26	6	36373674
Pubmed	E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta.	GLG1 SMAD2	8.16e-05	18	26	2	20530870
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	FAM98A HERC2 PCNX3 AHDC1 CDK13 GLG1 NKRF	8.63e-05	1497	26	7	31527615
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SAFB2 PEX1 HERC1 GLG1 TMEM181 SMAD2	1.22e-04	1084	26	6	11544199
Pubmed	KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4.	SAFB2 SAFB NKRF	1.25e-04	130	26	3	35545047
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	PEX1 HERC2 HERC1	1.52e-04	139	26	3	25476789
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HERC2 HERC1	1.73e-04	26	26	2	26949039
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	FRMD4A FAM98A PCNX3 AHDC1 NKRF	1.86e-04	732	26	5	34732716
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	HERC2 HERC1 CDK13 ALK	2.54e-04	420	26	4	28065597
Pubmed	GOLPH3 and GOLPH3L are broad-spectrum COPI adaptors for sorting into intra-Golgi transport vesicles.	GALNT2 GLG1	2.63e-04	32	26	2	34473204
Pubmed	TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.	SAFB2 FAM98A SAFB NKRF	2.78e-04	430	26	4	38172120
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SAFB2 FAM98A SAFB CDK13 NKRF	2.91e-04	807	26	5	22681889
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SAFB2 SAFB KIF18B AHDC1 CDK13 NKRF	3.18e-04	1294	26	6	30804502
Pubmed	Global landscape of HIV-human protein complexes.	FAM98A HERC2 MTCH1 GLG1	3.50e-04	457	26	4	22190034
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	SAFB2 FAM98A SAFB AHDC1 NKRF	3.64e-04	847	26	5	35850772
Pubmed	A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.	SAFB2 HERC2 ALK	3.75e-04	189	26	3	31594818
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	SAFB2 FAM98A SAFB HERC2 KIF18B NKRF	4.04e-04	1353	26	6	29467282
Pubmed	A molecular profile of a hematopoietic stem cell niche.	KIF18B TMEM181	4.12e-04	40	26	2	12226475
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	GALNT2 MTCH1 GLG1 TMEM181	4.87e-04	499	26	4	22810586
Pubmed	Identification of NPM-ALK interacting proteins by tandem mass spectrometry.	CDK13 ALK	5.69e-04	47	26	2	14968112
Pubmed	FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.	SAFB2 SAFB HERC2	6.06e-04	223	26	3	34226595
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	PEX1 HERC2 HERC1 MTCH1 CDK13 NKRF	6.87e-04	1496	26	6	32877691
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	SAFB2 SAFB GRIN3B RASAL3	9.94e-04	797	26	4	chr19p13
Cytoband	17q21.31	CCDC43 KIF18B	9.96e-04	82	26	2	17q21.31
Cytoband	19p13.3	SAFB2 GRIN3B	7.95e-03	237	26	2	19p13.3
GeneFamily	RNA binding motif containing	SAFB2 SAFB	1.49e-02	213	16	2	725
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HERC2 OXR1 CDK13 GLG1	4.46e-06	192	26	4	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HERC1 NFATC2IP CDK13 ALK	4.56e-06	193	26	4	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
Computational	Neighborhood of TPR	NFATC2IP CDK13 NKRF SMAD2	5.38e-05	147	16	4	MORF_TPR
Computational	Neighborhood of SS18	NFATC2IP CDK13 SMAD2	9.70e-05	62	16	3	MORF_SS18
Computational	Neighborhood of PPP2R5E	NFATC2IP NKRF SMAD2	2.31e-04	83	16	3	MORF_PPP2R5E
Computational	Neighborhood of PPP5C	GALNT2 CDK13 NKRF	3.04e-04	91	16	3	MORF_PPP5C
Computational	Neighborhood of CDC2L5	GALNT2 CDK13 NKRF	1.11e-03	142	16	3	MORF_CDC2L5
Computational	Neighborhood of FANCG	GALNT2 CDK13 NKRF	1.78e-03	167	16	3	MORF_FANCG
Drug	chlorotrianisene	SAFB2 SAFB KLK2	1.73e-06	21	26	3	CID000011289
Drug	pSAP	SAFB2 SAFB	1.88e-05	6	26	2	CID000007171
Drug	CI628M	SAFB2 SAFB	2.62e-05	7	26	2	CID003035794
Drug	4-hydroxyethynylestradiol	SAFB2 SAFB	3.50e-05	8	26	2	CID000066396
Drug	U23,469	SAFB2 SAFB	4.49e-05	9	26	2	CID000161922
Drug	h EE	SAFB ALK	5.61e-05	10	26	2	CID000446896
Drug	coumestrol	SAFB2 SAFB ALK	6.59e-05	69	26	3	CID005281707
Drug	Thiamphenicol [15318-45-3]; Down 200; 11.2uM; HL60; HT_HG-U133A	PEX1 GALNT2 AHDC1 GLG1	6.73e-05	195	26	4	1867_DN
Drug	PHA-00816795 [212631-79-3]; Up 200; 10uM; PC3; HT_HG-U133A	SAFB2 PEX1 CNNM1 SAFB	7.14e-05	198	26	4	7076_UP
Drug	Niflumic acid [4394-00-7]; Down 200; 14.2uM; HL60; HT_HG-U133A	GALNT2 AHDC1 CDK13 ALK	7.28e-05	199	26	4	2399_DN
Drug	ketononestrol aziridine	SAFB2 SAFB	9.71e-05	13	26	2	CID000130642
Drug	2-phenylindole	SAFB2 SAFB	9.71e-05	13	26	2	CID000013698
Drug	DP-TAT-59	SAFB2 SAFB	9.71e-05	13	26	2	CID003037015
Drug	NSC35770	SAFB2 SAFB HERC2	1.02e-04	80	26	3	CID000002800
Drug	benzophenone-2	SAFB2 SAFB	1.30e-04	15	26	2	CID000008571
Drug	NSC98536	SAFB2 SAFB	1.30e-04	15	26	2	CID000004080
Drug	AC1Q7B2S	SAFB2 SAFB	1.30e-04	15	26	2	CID000015019
Drug	alendronate	SAFB2 SAFB ALK	1.45e-04	90	26	3	CID000002088
Drug	TAT-59	SAFB2 SAFB	1.49e-04	16	26	2	CID003034829
Drug	OH-PCB 30	SAFB2 SAFB	1.49e-04	16	26	2	CID000105036
Disease	peripheral arterial disease, traffic air pollution measurement	CNNM1 FRMD4A OXR1 SMAD2	1.74e-05	194	24	4	EFO_0004265, EFO_0007908
Disease	carnosine measurement	FRMD4A OXR1	1.73e-04	24	24	2	EFO_0010470
Disease	coronary artery disease	GALNT2 PCNX3 MTCH1 AHDC1 ALK SMAD2	3.11e-04	1194	24	6	EFO_0001645
Disease	fibroblast growth factor basic measurement	FRMD4A PCNX3	1.05e-03	59	24	2	EFO_0008130
Disease	nucleotide measurement	GALNT2 ALK	1.61e-03	73	24	2	EFO_0010513
Disease	sleep duration, triglyceride measurement	GALNT2 ALK	3.23e-03	104	24	2	EFO_0004530, EFO_0005271
Disease	Tinnitus	PCNX3 MTCH1	4.99e-03	130	24	2	HP_0000360
Disease	gestational age	OXR1 ALK	5.60e-03	138	24	2	EFO_0005112

Protein segments in the cluster

Peptide	Gene	Start	Entry
MASWGGEKRGGAGGS	CCDC144NL	1	Q6NUI1
FGEAGAEWAGDKGGG	AHDC1	761	Q5TGY3
DTALGGGGGLSWAEK	CDK13	6	Q14004
HTGGGGEKAAGGFRW	RASAL3	26	Q86YV0
GEKAAGGFRWGRFAG	RASAL3	31	Q86YV0
DGGGGGFGSWLDGRL	CCDC43	16	Q96MW1
LWTGGKDTCGGDSGG	KLK2	201	P20151
SWGDGDFGKLGRGGS	HERC2	3176	O95714
LAGGAGGGAGRKEDW	GALNT2	31	Q10471
SWGDGDYGKLGHGNS	HERC1	481	Q15751
WSLGGRKGLGGSDGE	PCNX3	1936	Q9H6A9
DGGFPGLKWGGTHDG	KIF18B	46	Q86Y91
FGGGGGEFALWLDGD	OXR1	826	Q8N573
GGLFKESWRGGGGDE	FRMD4A	876	Q9P2Q2
RGGAGAGGGWKLAEE	GLG1	101	Q92896
MWGSDRLAGAGGGGA	PEX1	1	O43933
GDGKYGALRDGRWTG	GRIN3B	501	O60391
WARGGAAGMAGAGAG	MTCH1	11	Q9NZJ7
KMGWTGGGLGKSGEG	NKRF	561	O15226
RGGGRGNKHQGGWTD	FAM98A	371	Q8NCA5
GKRGRWSGGSGAGRG	NFATC2IP	6	Q8NCF5
GRDSRDGWGGYGSDK	SAFB	791	Q15424
KKWGWETRGGFGGGG	ALK	911	Q9UM73
GAGGGGKLFSLCAWD	CNNM1	176	Q9NRU3
CWEKRGGAGGDTKGG	TMEM181	71	Q9P2C4
LGWKKSAGGSGGAGG	SMAD2	16	Q15796
GWGGYGSDKRLSEGR	SAFB2	821	Q14151