Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	TRYPSIN_SER	CELA3B KLK4 F9 PRSS56	4.45e-05	90	41	4	IPR033116
Domain	TRYPSIN_HIS	CELA3B KLK4 F9 PRSS56	7.55e-05	103	41	4	IPR018114
Domain	TRYPSIN_SER	CELA3B KLK4 F9 PRSS56	8.44e-05	106	41	4	PS00135
Domain	TRYPSIN_HIS	CELA3B KLK4 F9 PRSS56	8.76e-05	107	41	4	PS00134
Domain	Peptidase_S1A	CELA3B KLK4 F9 PRSS56	1.08e-04	113	41	4	IPR001314
Domain	TRYPSIN_DOM	CELA3B KLK4 F9 PRSS56	1.16e-04	115	41	4	PS50240
Domain	Tryp_SPc	CELA3B KLK4 F9 PRSS56	1.24e-04	117	41	4	SM00020
Domain	Trypsin	CELA3B KLK4 F9 PRSS56	1.41e-04	121	41	4	PF00089
Domain	Trypsin_dom	CELA3B KLK4 F9 PRSS56	1.41e-04	121	41	4	IPR001254
Domain	Peptidase_S1_PA	CELA3B KLK4 F9 PRSS56	1.50e-04	123	41	4	IPR009003
Domain	Band3_cytoplasmic_dom	SLC4A4 SLC4A1	1.68e-04	9	41	2	IPR013769
Domain	Band_3_cyto	SLC4A4 SLC4A1	1.68e-04	9	41	2	PF07565
Domain	-	SLC4A4 SLC4A1	1.68e-04	9	41	2	3.40.1100.10
Domain	PTrfase/Anion_transptr	SLC4A4 SLC4A1	2.09e-04	10	41	2	IPR016152
Domain	HCO3_cotransp	SLC4A4 SLC4A1	2.09e-04	10	41	2	PF00955
Domain	HCO3_transpt_euk	SLC4A4 SLC4A1	2.09e-04	10	41	2	IPR003020
Domain	HCO3_transpt_C	SLC4A4 SLC4A1	2.09e-04	10	41	2	IPR011531
Domain	EGF_Ca-bd_CS	JAG2 MEGF8 F9	1.25e-03	97	41	3	IPR018097
Domain	EGF_CA	JAG2 MEGF8 F9	1.33e-03	99	41	3	PS01187
Domain	ASX_HYDROXYL	JAG2 MEGF8 F9	1.37e-03	100	41	3	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	JAG2 MEGF8 F9	1.62e-03	106	41	3	IPR000152
Domain	-	MXD4 BHLHA9 MSGN1	1.75e-03	109	41	3	4.10.280.10
Domain	HLH	MXD4 BHLHA9 MSGN1	1.85e-03	111	41	3	PF00010
Domain	HLH	MXD4 BHLHA9 MSGN1	2.10e-03	116	41	3	SM00353
Domain	BHLH	MXD4 BHLHA9 MSGN1	2.15e-03	117	41	3	PS50888
Domain	bHLH_dom	MXD4 BHLHA9 MSGN1	2.20e-03	118	41	3	IPR011598
Domain	EGF_CA	JAG2 MEGF8 F9	2.42e-03	122	41	3	SM00179
Domain	EGF-like_Ca-bd_dom	JAG2 MEGF8 F9	2.53e-03	124	41	3	IPR001881
Domain	Growth_fac_rcpt_	JAG2 EPHB6 MEGF8	4.83e-03	156	41	3	IPR009030
Domain	CUB	MEGF8 CSMD3	5.18e-03	49	41	2	PF00431
Domain	CUB	MEGF8 CSMD3	5.39e-03	50	41	2	SM00042
Domain	-	MEGF8 CSMD3	5.82e-03	52	41	2	2.60.120.290
Domain	CUB	MEGF8 CSMD3	6.04e-03	53	41	2	PS01180
Domain	CUB_dom	MEGF8 CSMD3	6.95e-03	57	41	2	IPR000859
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A4 SLC4A1	1.70e-04	10	28	2	M27335
Pathway	REACTOME_BICARBONATE_TRANSPORTERS	SLC4A4 SLC4A1	1.70e-04	10	28	2	MM15073
Pubmed	Somatic mutations and germline sequence variants in patients with familial colorectal cancer.	EPHB6 CSMD3	1.49e-06	2	43	2	21351276
Pubmed	A substrate access tunnel in the cytosolic domain is not an essential feature of the solute carrier 4 (SLC4) family of bicarbonate transporters.	SLC4A4 SLC4A1	1.49e-06	2	43	2	24121512
Pubmed	Erk and MAPK signaling is essential for intestinal development through Wnt pathway modulation.	JAG2 TRPM5 PTCH1	2.75e-05	47	43	3	32747435
Pubmed	Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2.	CHSY3 PTCH1	9.78e-05	12	43	2	29287114
Pubmed	The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.	TRPM5 SLC4A1 BHLHA9 MSGN1	1.37e-04	212	43	4	19521566
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ASXL1 MEGF8 TTC28 CSMD3 RUSC2	1.43e-04	407	43	5	12693553
Pubmed	Hedgehog-FGF signaling axis patterns anterior mesoderm during gastrulation.	PTCH1 MSGN1	1.55e-04	15	43	2	32561646
Pubmed	Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.	PTCH1 MEGF8	1.55e-04	15	43	2	34486668
Pubmed	Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis.	JAG2 PTCH1	1.77e-04	16	43	2	25053435
Pubmed	GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation.	SHROOM3 SLC4A1	2.01e-04	17	43	2	29237740
Pubmed	Tbx1 regulates oral epithelial adhesion and palatal development.	JAG2 PTCH1	2.80e-04	20	43	2	22371266
Pubmed	Functions of FGF signalling from the apical ectodermal ridge in limb development.	JAG2 PTCH1	3.09e-04	21	43	2	12152071
Pubmed	Functional genetic analysis of mouse chromosome 11.	WDR81 SLC4A1	3.72e-04	23	43	2	12955145
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	JAG2 ZNF398 SHROOM3 PTCH1 MEGF8 BCL2L11 MXD4	3.80e-04	1105	43	7	35748872
Pubmed	Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.	TUBGCP6 ACO2	4.05e-04	24	43	2	11258795
Pubmed	Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.	ASXL1 CSMD3 DDHD1 RNF19B	4.70e-04	293	43	4	31741433
Pubmed	The DNA sequence of human chromosome 22.	TUBGCP6 TTC28 P2RX6 ACO2	5.14e-04	300	43	4	10591208
Pubmed	SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning.	PTCH1 MXD4	5.93e-04	29	43	2	34822715
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SHROOM3 GIGYF1 MEGF8 TTC28 EIF4B RUSC2	6.31e-04	861	43	6	36931259
Pubmed	p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.	JAG2 PTCH1	6.35e-04	30	43	2	16524929
Pubmed	pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development.	JAG2 PTCH1	6.35e-04	30	43	2	17257418
Pubmed	Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development.	JAG2 PTCH1	8.17e-04	34	43	2	23123965
Pubmed	5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival.	PTCH1 BCL2L11	8.66e-04	35	43	2	28031476
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	IBTK GIGYF1 TTC28 DDHD1 RUSC2	1.20e-03	650	43	5	38777146
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Pvalb-Pvalb_Reln_Itm2a\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMEM132C SCRT1 SLC4A4 BCL2L11	1.13e-05	144	43	4	0bbe670454846cf9bc7464ae4e91488415c4111d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 TRPM5 MARCHF11 APCDD1L	1.58e-05	157	43	4	2c5295043611bac7dfa4aef2146681bce4a33a8f
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPHB6 WDR81 IBTK P2RX6	1.75e-05	161	43	4	2849fbc9611af208241b33da3cd18290aafe426b
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNG8 SLC4A4 PTCH1 CSMD3	1.97e-05	166	43	4	3b67064a5149e72f895344d938c64b8ff65247f5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ASXL1 SHROOM3 CSMD3 SLC4A1	2.77e-05	181	43	4	30729f0364f719c044712a51453e22dc2c1a232b
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TMEM132C SLC4A4 PTCH1 TTC28	3.63e-05	194	43	4	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	TMEM132C SLC4A4 PTCH1 TTC28	3.70e-05	195	43	4	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
Disease	Renal Tubular Acidosis, Type II	SLC4A4 SLC4A1	1.88e-06	2	41	2	C0268435
Disease	Renal tubular acidosis	SLC4A4 SLC4A1	1.13e-05	4	41	2	C0001126
Disease	renal tubular acidosis (is_implicated_in)	SLC4A4 SLC4A1	1.13e-05	4	41	2	DOID:14219 (is_implicated_in)
Disease	Distal Renal Tubular Acidosis	SLC4A4 SLC4A1	1.88e-05	5	41	2	C1704380
Disease	renal tubular acidosis (implicated_via_orthology)	SLC4A4 SLC4A1	5.25e-05	8	41	2	DOID:14219 (implicated_via_orthology)
Disease	anemia (implicated_via_orthology)	SLC4A4 SLC4A1	1.96e-04	15	41	2	DOID:2355 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TDSHTPNGGGLGGIC	ACO2	191	Q99798
CGDPGTPGHGSRQES	CSMD3	3056	Q7Z407
CEQGDGGTEGHSPSG	SLC4A1	201	P02730
CHGPAARGDTGDTGA	BHLHA9	136	Q7RTU4
GAHTAPAAGEAGGSC	APCDD1L	16	Q8NCL9
QGNPEGNHGGEGDSC	BCL2L11	41	O43521
RGSSSGDGGEACGHP	ASXL1	661	Q8IXJ9
ERGGGRTEDGHSCGA	RBFA	326	Q8N0V3
DPGAGPGDHNRSDCG	LARGE2	71	Q8N3Y3
GHDQKDSCNGDSGGP	KLK4	196	Q9Y5K2
GLPCEHGGASSGGSE	MSGN1	66	A6NI15
LQSGTGGDSGFGPHC	MXD4	186	Q14582
CGEEEGRGGGGSSHL	GIGYF1	261	O75420
CGHGPGGRLGHGDEQ	IBTK	201	Q9P2D0
DGDGRTTRAGGCGHD	JAG2	51	Q9Y219
EGGRDSCQGDSGGPH	F9	401	P00740
QGGAHCGDDGAGGSL	MEGF8	876	Q7Z7M0
DGRGGHSCRGGVDTA	LAGE3	16	Q14657
HPEGGQGCDSGSAEQ	TUBGCP6	836	Q96RT7
GDDGTPHRGGGGASE	CACNG8	61	Q8WXS5
GGDIRSGCNGDSGGP	CELA3B	206	P08861
SGGRGGVDHGDQGLS	FRMD6-AS1	241	P0C7T7
GHGGSRCRGAESGDA	MARCHF11	6	A6NNE9
ESAGDHGSAGRGGCK	DNAAF1	26	Q8NEP3
QGGDRDGDHVCSPTG	DDHD1	206	Q8NEL9
DEDCPEGEGGTHSHG	P2RX6	141	O15547
AGGVDSCQGDSGGPL	PRSS56	276	P0CW18
GNSSRGPGDGGNRDH	EIF4B	541	P23588
ESGGREGGYGCPHAS	RUSC2	341	Q8N2Y8
SGGGGSEEDPPCRHQ	RNF19B	626	Q6ZMZ0
GPGAAGAGGRHACGE	SCRT1	181	Q9BWW7
TVHPGNERGDCAGGD	TMEM132C	231	Q8N3T6
EGRQEPASGGGGTCH	EPHB6	411	O15197
NAAEPQDRGGGGSGC	PTCH1	6	Q13635
RGCEGDGPEHGVEEG	SHROOM3	1401	Q8TF72
RDGRPGSSHNGSGDG	CHSY3	146	Q70JA7
GGGPRSSQHCGEGSQ	TRPM5	1126	Q9NZQ8
GEGHNLSTDGLGPDC	SMTNL1	281	A8MU46
LRSGHNGGCGGDSDP	ZNF398	586	Q8TD17
GSEGGGPGGRQDHDR	TTC28	2011	Q96AY4
GGGGHGDCEELQRTG	SLC4A4	426	Q9Y6R1
GGGCPQDDGHSGTFG	WDR81	1546	Q562E7
AEGGGQGGDPSRCHV	ZNF784	91	Q8NCA9