Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	synaptic vesicle priming	CADPS ERC1 SYP UNC13C	7.06e-06	31	83	4	GO:0016082
Domain	PH	RTKN2 IQSEC3 CADPS SH3BP2 OSBPL11 AGAP7P ARHGAP20 AGAP4 AGAP6	3.96e-06	278	83	9	SM00233
Domain	PH_DOMAIN	RTKN2 IQSEC3 CADPS SH3BP2 OSBPL11 AGAP7P ARHGAP20 AGAP4 AGAP6	4.07e-06	279	83	9	PS50003
Domain	PH_domain	RTKN2 IQSEC3 CADPS SH3BP2 OSBPL11 AGAP7P ARHGAP20 AGAP4 AGAP6	4.19e-06	280	83	9	IPR001849
Domain	PH_dom-like	RTKN2 IQSEC3 CADPS SH3BP2 OSBPL11 AGAP7P ARHGAP20 WDFY4 AGAP4 AGAP6	1.89e-05	426	83	10	IPR011993
Domain	ATPase_dyneun-rel_AAA	MDN1 DYNC2H1 DNAH1	2.97e-05	14	83	3	IPR011704
Domain	AAA_5	MDN1 DYNC2H1 DNAH1	2.97e-05	14	83	3	PF07728
Domain	DUF1041	CADPS UNC13C	1.93e-04	5	83	2	SM01145
Domain	ArfGap	AGAP7P AGAP4 AGAP6	2.84e-04	29	83	3	SM00105
Domain	ArfGap	AGAP7P AGAP4 AGAP6	2.84e-04	29	83	3	PF01412
Domain	ARFGAP	AGAP7P AGAP4 AGAP6	2.84e-04	29	83	3	PS50115
Domain	ArfGAP	AGAP7P AGAP4 AGAP6	2.84e-04	29	83	3	IPR001164
Domain	-	RTKN2 IQSEC3 CADPS SH3BP2 OSBPL11 ARHGAP20 AGAP4 AGAP6	3.45e-04	391	83	8	2.30.29.30
Domain	DUF1041	CADPS UNC13C	4.04e-04	7	83	2	PF06292
Domain	Munc13_1	CADPS UNC13C	4.04e-04	7	83	2	IPR014770
Domain	CAPS_dom	CADPS UNC13C	4.04e-04	7	83	2	IPR010439
Domain	MHD1	CADPS UNC13C	4.04e-04	7	83	2	PS51258
Domain	Yippee/Mis18/Cereblon	MIS18A CRBN	5.37e-04	8	83	2	IPR004910
Domain	Yippee-Mis18	MIS18A CRBN	5.37e-04	8	83	2	PF03226
Domain	PH	RTKN2 CADPS SH3BP2 OSBPL11 AGAP7P AGAP4	5.47e-04	229	83	6	PF00169
Domain	HMG_box_2	UBTF HMGB4	6.88e-04	9	83	2	PF09011
Domain	Dynein_heavy_chain_D4_dom	DYNC2H1 DNAH1	1.72e-03	14	83	2	IPR024317
Domain	Dynein_HC_stalk	DYNC2H1 DNAH1	1.72e-03	14	83	2	IPR024743
Domain	Dynein_heavy_dom-2	DYNC2H1 DNAH1	1.72e-03	14	83	2	IPR013602
Domain	DHC_N2	DYNC2H1 DNAH1	1.72e-03	14	83	2	PF08393
Domain	MT	DYNC2H1 DNAH1	1.72e-03	14	83	2	PF12777
Domain	AAA_8	DYNC2H1 DNAH1	1.72e-03	14	83	2	PF12780
Domain	DHC_fam	DYNC2H1 DNAH1	1.97e-03	15	83	2	IPR026983
Domain	Dynein_heavy_dom	DYNC2H1 DNAH1	1.97e-03	15	83	2	IPR004273
Domain	Dynein_heavy	DYNC2H1 DNAH1	1.97e-03	15	83	2	PF03028
Domain	SH3_9	MAP3K10 TNK2 UBASH3A	5.07e-03	78	83	3	PF14604
Domain	WD40	LRWD1 COPA STRAP WDR25 WDFY4	5.95e-03	259	83	5	PF00400
Domain	WD40_repeat_CS	LRWD1 COPA STRAP WDFY4	6.15e-03	164	83	4	IPR019775
Domain	WD40	LRWD1 COPA STRAP WDR25 WDFY4	6.85e-03	268	83	5	SM00320
Domain	WD40_repeat	LRWD1 COPA STRAP WDR25 WDFY4	7.28e-03	272	83	5	IPR001680
Domain	WD_REPEATS_1	LRWD1 COPA STRAP WDR25 WDFY4	7.97e-03	278	83	5	PS00678
Domain	WD_REPEATS_2	LRWD1 COPA STRAP WDR25 WDFY4	8.08e-03	279	83	5	PS50082
Pubmed	The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.	SYP AGAP7P AGAP4 AGAP6	2.57e-08	13	87	4	27713690
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	MRE11 STRAP ERC1 PRRC2C UBTF CARMIL1 OSBPL11 TFIP11 ICE1 UPF1 GOLGA5 THOC2 ADD3	5.69e-07	934	87	13	33916271
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	MRE11 STRAP ERC1 PRRC2C OSBPL11 TFIP11 UPF1 THOC2 THRAP3 ADD3	1.19e-06	549	87	10	38280479
Pubmed	GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.	AGAP7P AGAP4 AGAP6	1.26e-06	9	87	3	12640130
Pubmed	AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.	AGAP7P AGAP4 AGAP6	1.79e-06	10	87	3	20664521
Pubmed	AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.	AGAP7P AGAP4 AGAP6	2.46e-06	11	87	3	15381706
Pubmed	GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.	AGAP7P AGAP4 AGAP6	5.39e-06	14	87	3	22453919
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	MRE11 LRWD1 COPA STRAP UBTF UPF1 THOC2 F5 THRAP3 HNRNPH2	6.09e-06	660	87	10	32780723
Pubmed	Do baseline Cereblon gene expression and IL-6 receptor expression determine the response to thalidomide-dexamethasone treatment in multiple myeloma patients?	CRBN IL6R	6.19e-06	2	87	2	24118365
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	MRE11 COPA DPPA4 ERC1 HLTF UPF1 CRBN HNRNPH2	7.02e-06	396	87	8	26687479
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	SYNE1 OSBPL11 TFIP11 ARHGAP20 F5 THRAP3	1.06e-05	197	87	6	20811636
Pubmed	Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.	ANKFY1 LAD1 UBASH3A THRAP3	1.13e-05	55	87	4	18570454
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	MRE11 COPA STRAP ERC1 PRRC2C UBTF LAD1 UPF1 THOC2 F5 THRAP3 HNRNPH2 ADD3	1.44e-05	1257	87	13	36526897
Pubmed	BioID Performed on Golgi Enriched Fractions Identify C10orf76 as a GBF1 Binding Protein Essential for Golgi Maintenance and Secretion.	MRE11 PDE1A STRAP ERC1 PRRC2C GOLGA5	1.78e-05	216	87	6	31519766
Pubmed	Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation.	MRE11 PRIMPOL	1.85e-05	3	87	2	26627254
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MRE11 LRWD1 MDN1 COPA CARMIL1 OSBPL11 TJAP1 TFIP11 THOC2 THRAP3	2.40e-05	774	87	10	15302935
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	MDN1 DIABLO UBTF SYNE1 THOC2 THRAP3	2.79e-05	234	87	6	36243803
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	IQSEC3 ANKFY1 MDN1 STRAP ERC1 PRRC2C SYNE1 TJAP1 UPF1 THRAP3 RAI1	2.85e-05	963	87	11	28671696
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	RTKN2 MDN1 COPA STRAP DYNC2H1 ERC1 SYNE1 MACROD1 UPF1 DNAH1	3.42e-05	807	87	10	30575818
Pubmed	Identification of Host Factors Involved in Human Cytomegalovirus Replication, Assembly, and Egress Using a Two-Step Small Interfering RNA Screen.	COPA ERC1	3.70e-05	4	87	2	29946045
Pubmed	Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2.	MACROD1 SYP	3.70e-05	4	87	2	30227424
Pubmed	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.	ERC1 SYP UNC13C	3.77e-05	26	87	3	17124501
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	ZNF10 SYNE1 MIS18A TFIP11 CEP295	4.00e-05	151	87	5	17043677
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	KCNH7 ANKFY1 CARMIL1 AGAP7P AGAP4 AGAP6 ADD3	7.24e-05	405	87	7	38187761
Pubmed	Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.	COPA STRAP HAUS3 UPF1 THOC2	8.06e-05	175	87	5	37866880
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	MRE11 LRWD1 COPA STRAP ERC1 PRRC2C HAUS3 UPF1 THRAP3	8.44e-05	724	87	9	36232890
Pubmed	SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice.	SYNE1 SYP	1.29e-04	7	87	2	19509342
Pubmed	Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.	ERC1 UNC13C	1.29e-04	7	87	2	36398873
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SECISBP2L MRE11 COPA STRAP PRRC2C LAD1 TFIP11 UPF1 THOC2 THRAP3 CRBN ADD3	1.55e-04	1371	87	12	36244648
Pubmed	Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.	CADPS UNC13C	1.72e-04	8	87	2	25609709
Pubmed	Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing.	RTKN2 UNC13C	1.72e-04	8	87	2	27376238
Pubmed	Genetics of rheumatoid arthritis contributes to biology and drug discovery.	RTKN2 UBASH3A WDFY4 IL6R	1.85e-04	112	87	4	24390342
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	MRE11 MDN1 COPA STRAP UPF1 HNRNPH2	1.91e-04	332	87	6	32786267
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	MRE11 ANKFY1 MDN1 COPA STRAP UPF1 THOC2 ADD3	2.01e-04	638	87	8	33239621
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	MRE11 P4HA2 ANKFY1 COPA DIABLO DYNC2H1 HLTF OSBPL11 ICE1 CRBN	2.08e-04	1005	87	10	19615732
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	MDN1 COPA UBTF THOC2 THRAP3 HNRNPH2	2.17e-04	340	87	6	29478914
Pubmed	Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.	MRE11 HLTF	2.20e-04	9	87	2	28628639
Pubmed	PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.	MDN1 COPA STRAP UPF1 THOC2	2.20e-04	217	87	5	31685992
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	MRE11 ANKFY1 MDN1 COPA STRAP DIABLO DYNC2H1 UBTF SYNE1 UPF1 THOC2 THRAP3	2.21e-04	1425	87	12	30948266
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MRE11 MDN1 COPA PRRC2C UBTF UPF1 THOC2 RAI1	2.35e-04	653	87	8	22586326
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	MRE11 LRWD1 MDN1 COPA UBTF SYNE1 THOC2 F5 THRAP3 HNRNPH2	2.41e-04	1024	87	10	24711643
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	COPA STRAP ERC1 UPF1 GOLGA5 CRBN HNRNPH2	2.45e-04	494	87	7	26831064
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	MRE11 MDN1 COPA STRAP ERC1 PRRC2C HAUS3 THOC2 THRAP3	2.72e-04	847	87	9	35235311
Pubmed	The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival.	CADPS SYP	2.75e-04	10	87	2	14715936
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ANKFY1 ERC1 PRRC2C ICE1 F5 THRAP3	2.99e-04	361	87	6	26167880
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	KCNH7 ANKFY1 STRAP CADPS AGAP7P GOLGA5 AGAP4	3.08e-04	513	87	7	25798074
Pubmed	Maternal DCAF13 Regulates Chromatin Tightness to Contribute to Embryonic Development.	DPPA4 UBTF	3.35e-04	11	87	2	31000741
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	MRE11 MDN1 ERC1 PRRC2C UPF1 GOLGA5	3.66e-04	375	87	6	32788342
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	COPA STRAP TFIP11 THOC2 THRAP3	3.77e-04	244	87	5	29884807
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MRE11 P4HA2 SIAE UBTF SREBF2 OSBPL11 TFIP11 CEP295 THOC2 WDFY4	3.79e-04	1084	87	10	11544199
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	MRE11 LRWD1 MDN1 COPA UBTF HLTF TFIP11 THOC2 THRAP3 HNRNPH2 RAI1	3.81e-04	1294	87	11	30804502
Pubmed	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.	MDN1 DIABLO THRAP3 CRBN HNRNPH2	3.99e-04	247	87	5	32989298
Pubmed	Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.	DUSP21 DIABLO	4.02e-04	12	87	2	18385140
Pubmed	Genome-wide association study of age at menarche in African-American women.	STAG3L4 UNC13C	4.02e-04	12	87	2	23599027
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	COPA STRAP PRRC2C TFIP11 UPF1 THOC2 THRAP3 HNRNPH2	4.22e-04	713	87	8	29802200
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	MRE11 LRWD1 STRAP PRRC2C UBTF HLTF UPF1 THOC2 THRAP3 RAI1	4.34e-04	1103	87	10	34189442
Pubmed	Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene).	F5 IL6R	4.74e-04	13	87	2	20484876
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	PRRC2C SYNE1 UPF1 THRAP3 HNRNPH2	4.87e-04	258	87	5	37794589
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	MRE11 OTC MDN1 CEP295 ICE1 ARHGAP20 RAI1 RGL4	5.20e-04	736	87	8	29676528
Pubmed	Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.	ERC1 SYP	5.52e-04	14	87	2	21228161
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DYNC2H1 DNAH1	5.52e-04	14	87	2	9373155
Pubmed	Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.	UBASH3A CTSH	5.52e-04	14	87	2	20647273
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MRE11 LRWD1 ANKFY1 MDN1 COPA UBTF HLTF TFIP11 UPF1 THRAP3 HNRNPH2	5.53e-04	1353	87	11	29467282
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	IQSEC3 KCNH7 CADPS ERC1 PRRC2C MAP3K10 SYP THRAP3 HNRNPH2 ADD3	5.57e-04	1139	87	10	36417873
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	IQSEC3 ANKFY1 CADPS ERC1 PRRC2C SYNE1	5.63e-04	407	87	6	12693553
Pubmed	Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts.	FAIM MACROD1 SYP	5.64e-04	64	87	3	12107411
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	COPA DPPA4 UBTF TFIP11 UPF1	5.88e-04	269	87	5	29511261
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	RTKN2 LRWD1 COPA STRAP SYNE1 CARMIL1 HAUS3 TFIP11 THRAP3 CRBN	6.20e-04	1155	87	10	20360068
Pubmed	LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.	CADPS SYP	6.36e-04	15	87	2	21307259
Pubmed	An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks.	ERC1 MACROD1	6.36e-04	15	87	2	25735744
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	MRE11 LRWD1 MDN1 COPA HLTF UPF1 THRAP3	6.52e-04	582	87	7	20467437
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	IQSEC3 SYNE1 AGAP7P AGAP4 AGAP6	7.15e-04	281	87	5	28706196
Pubmed	A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.	PRRC2C UPF1 THOC2 THRAP3	7.48e-04	162	87	4	31363146
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	TNK2 UPF1 AGAP7P AGAP4 AGAP6 ADD3	7.49e-04	430	87	6	32581705
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	MRE11 COPA STRAP ERC1 PRRC2C CARMIL1 HLTF TFIP11 UPF1 THRAP3 HNRNPH2	8.00e-04	1415	87	11	28515276
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	MRE11 MDN1 PRRC2C UBTF TFIP11 THRAP3 RAI1	8.18e-04	605	87	7	28977666
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	MDN1 COPA UBTF MIS18A HLTF TFIP11 THOC2 THRAP3 HNRNPH2	8.28e-04	989	87	9	36424410
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	IQSEC3 COPA CADPS ERC1 PRRC2C SYNE1 CARMIL1 SYP UPF1 THRAP3 ADD3	8.77e-04	1431	87	11	37142655
Pubmed	Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.	ICE1 THRAP3	9.22e-04	18	87	2	20064376
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	SECISBP2L STRAP PRRC2C UBTF SYNE1 UPF1 THRAP3 HNRNPH2	9.45e-04	807	87	8	22681889
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	KCNH7 ANKFY1 MACROD1 UPF1 CRBN	1.02e-03	304	87	5	32235678
Pubmed	Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.	SIAE SYNE1	1.03e-03	19	87	2	18711365
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	STRAP ERC1 PRRC2C UPF1 THRAP3 HNRNPH2	1.08e-03	462	87	6	31138677
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	SECISBP2L COPA STRAP SH3BP2 TJAP1 HAUS3 UPF1 THRAP3 ADD3	1.16e-03	1038	87	9	26673895
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CARMIL1 SH3BP2 MACROD1 SREBF2 TJAP1 TNK2 WDR25 THRAP3 IL6R RAI1 DNAH1	1.21e-03	1489	87	11	28611215
Pubmed	A novel functional role for MMSET in RNA processing based on the link between the REIIBP isoform and its interaction with the SMN complex.	STRAP THRAP3	1.26e-03	21	87	2	24923560
Pubmed	Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.	DYNC2H1 PLD5	1.26e-03	21	87	2	24057671
Pubmed	Shared and distinct genetic variants in type 1 diabetes and celiac disease.	UBASH3A CTSH	1.26e-03	21	87	2	19073967
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DYNC2H1 SYNE1 CARMIL1 THRAP3	1.27e-03	187	87	4	26460568
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	MRE11 MDN1 STRAP UBTF TFIP11 UPF1 THOC2 THRAP3	1.29e-03	847	87	8	35850772
Pubmed	A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.	KCNH7 DIABLO CADPS	1.29e-03	85	87	3	23055939
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	MRE11 UBTF SYNE1 SREBF2 UPF1	1.29e-03	321	87	5	32098917
Pubmed	UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.	COPA DYNC2H1 UBTF HLTF THOC2 THRAP3	1.48e-03	491	87	6	36273042
Pubmed	Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.	UPF1 CRBN HNRNPH2	1.52e-03	90	87	3	33087562
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	MDN1 UBTF CARMIL1 CCDC187 TFIP11 RAI1	1.57e-03	497	87	6	36774506
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	MRE11 MDN1 COPA MIS18A HLTF TFIP11 UPF1 THOC2 THRAP3 HNRNPH2	1.68e-03	1318	87	10	30463901
Pubmed	The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.	PRRC2C HLTF THRAP3 HNRNPH2	1.72e-03	203	87	4	35012549
Pubmed	Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.	ADAD1 UBASH3A	1.79e-03	25	87	2	21829393
Pubmed	The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.	MRE11 STRAP PRRC2C	1.88e-03	97	87	3	37151849
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	STRAP DYNC2H1 ERC1 UPF1 THRAP3	2.08e-03	358	87	5	32460013
Cytoband	10q11.23	AGAP7P WDFY4 AGAP6	3.44e-05	33	87	3	10q11.23
Cytoband	Ensembl 112 genes in cytogenetic band chr10q11	AGAP7P WDFY4 AGAP4 AGAP6	4.65e-04	188	87	4	chr10q11
Cytoband	3p21.1	IL17RB DNAH1	2.91e-03	42	87	2	3p21.1
Cytoband	11q21	MRE11 CEP295	3.19e-03	44	87	2	11q21
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RTKN2 CADPS SH3BP2 OSBPL11 AGAP7P AGAP4 AGAP6	9.62e-07	206	47	7	682
GeneFamily	ArfGAPs	AGAP7P AGAP4 AGAP6	8.50e-05	33	47	3	395
GeneFamily	WD repeat domain containing	LRWD1 COPA STRAP WDR25 WDFY4	5.74e-04	262	47	5	362
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	AGAP4 AGAP6	8.77e-04	17	47	2	1291
GeneFamily	Ankyrin repeat domain containing	ANKFY1 AGAP7P AGAP4 AGAP6	3.56e-03	242	47	4	403
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL6R IL17RB	5.33e-03	42	47	2	602
GeneFamily	X-linked mental retardation\|Angiotensin receptors	SYP THOC2	8.38e-03	53	47	2	103
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SECISBP2L OTC PRRC2C UBTF ARHGAP20 THRAP3	2.05e-06	191	87	6	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SECISBP2L OTC PRRC2C UBTF ARHGAP20 THRAP3	2.05e-06	191	87	6	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	MRE11 MDN1 CEP295 ICE1 WDFY4	1.92e-05	167	87	5	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP54 DYNC2H1 CCDC187 CFAP157 DNAH1	2.03e-05	169	87	5	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	FAIM CARMIL1 BIVM TFIP11 PLD5	2.09e-05	170	87	5	09bcbc7eb3b1d35cf03f01ce2f2fe37373382dd4
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZNF10 CEP295 UPF1 UBASH3A IL6R	2.21e-05	172	87	5	a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell	nucseq-Epithelial-Epithelial_Neuro-Secretory\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KCNH7 CADPS SYP F5 IL17RB	2.21e-05	172	87	5	d0cdedd734406988a9a93d7300c7b1a8b4b45c38
ToppCell	(2)_NK/T-(230)_CD4+/CD25+_Reg_T_cell\|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)	RTKN2 F5 WDFY4 IL6R IL17RB	2.82e-05	181	87	5	ad14c7111d4fb924afd233cb114447f195373a7c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A CFAP54 SYNE1 TLL2 F5	2.82e-05	181	87	5	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A CFAP54 SYNE1 TLL2 F5	2.82e-05	181	87	5	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A CFAP54 SYNE1 TLL2 F5	3.13e-05	185	87	5	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE1A CFAP54 SYNE1 TLL2 F5	3.13e-05	185	87	5	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 PDE1A KCNH7 CADPS SYP	3.30e-05	187	87	5	e04a84989d624378141042768383b9c846901f2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 PDE1A KCNH7 CADPS SYP	3.30e-05	187	87	5	24cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IQSEC3 PDE1A KCNH7 CADPS SYP	3.30e-05	187	87	5	2f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TRHDE KCNH7 DYNC2H1 UNC13C TOP6BL	3.47e-05	189	87	5	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SECISBP2L OTC PRRC2C UBTF ARHGAP20	3.65e-05	191	87	5	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP54 DYNC2H1 SYNE1 CTSH CFAP157	3.83e-05	193	87	5	bdb7401dd9059032f930f2b575f2ef8e504b6594
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP54 DYNC2H1 SYNE1 CCDC187 CFAP157	3.93e-05	194	87	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	Sigmoid-T_cell-Treg\|T_cell / Region, Cell class and subclass	RTKN2 SIAE F5 IL6R ADD3	4.33e-05	198	87	5	e2d2f9f209f77d0c48cfe3e9902c0ae0795511b2
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	CFAP54 DYNC2H1 SYNE1 CCDC187 CFAP157	4.54e-05	200	87	5	6a2ccc71a0cbe04a542c379b28b5006de53981c3
Disease	cerebral palsy (implicated_via_orthology)	AGAP7P AGAP4 AGAP6 ADD3	1.21e-08	10	83	4	DOID:1969 (implicated_via_orthology)
Disease	bipolar disorder	SIAE SYNE1 CARMIL1 MACROD1 TOP6BL CTSH CRBN ADD3	2.22e-04	577	83	8	MONDO_0004985
Disease	urate measurement, bone density	ERC1 SYNE1 CARMIL1 ACSM6 THAP9 CRBN JHY DNAH1	3.55e-04	619	83	8	EFO_0003923, EFO_0004531
Disease	sialate O-acetylesterase measurement	SIAE GOLGA5	5.07e-04	12	83	2	EFO_0803073
Disease	Brain Ischemia	DIABLO F5 ADD3	6.54e-04	60	83	3	C0007786
Disease	Cerebral Ischemia	DIABLO F5 ADD3	6.54e-04	60	83	3	C0917798
Disease	calcium/calmodulin-dependent protein kinase type 1 measurement	F5 IL6R	9.14e-04	16	83	2	EFO_0008062
Disease	myopia (is_implicated_in)	P4HA2 PRIMPOL	9.14e-04	16	83	2	DOID:11830 (is_implicated_in)
Disease	uric acid measurement	PDE1A DYNC2H1 UBTF CARMIL1 MACROD1 TOP6BL F5	1.67e-03	610	83	7	EFO_0004761
Disease	TEMPS-A questionnaire	DYNC2H1 CEP295	2.25e-03	25	83	2	EFO_0004783

Protein segments in the cluster

Peptide	Gene	Start	Entry
FIWMKFHSTTAVSEK	TRHDE	871	Q9UKU6
WSFERMTQLSKKAAS	ACSM6	86	Q6P461
CKRSMRWSNLFTSEK	AGAP4	221	Q96P64
KDATSTSSWELLMEA	CFAP54	861	Q96N23
SSFSKSPWAMTERKH	CCDC187	421	A0A096LP49
SPRTKITWMKAEDSS	ADD3	461	Q9UEY8
SASSEEERKSWMALL	SH3BP2	111	P78314
SHIGWKFTATKKDMS	CRBN	396	Q96SW2
ASSTSMEKAKGKEWT	DPPA4	6	Q7L190
ASFHQDSAWKKMSSI	BIVM	471	Q86UB2
DSAWKKMSSIHERRN	BIVM	476	Q86UB2
SSMSSSDKLTRWEVL	ADAD1	381	Q96M93
MAALKSWLSRSVTSF	DIABLO	1	Q9NR28
EFHKVTTNRMWETTK	CFAP157	211	Q5JU67
SLKTRTFSHASDTWM	TNK2	301	Q07912
CKRSMRWSNLFTSEK	AGAP6	221	Q5VW22
SKVQSWFESSLSHMK	RAI1	936	Q7Z5J4
ESKLSSSMNSIKTFW	ERC1	176	Q8IUD2
LTSRVTAHWEKFMAT	LRWD1	141	Q9UFC0
ASHWDDLRKEDFSSM	ANKFY1	191	Q9P2R3
DGLSKETVLSSWMAK	CADPS	226	Q9ULU8
MAVSRKDWSALSSLA	LAD1	1	O00515
LAREWHKTTKMSAAG	MAP3K10	251	Q02779
SKAMADFTTWKTHLL	MDN1	4471	Q9NU22
LEMLWKFHSSSDSQT	JHY	541	Q6NUN7
QKSWDFMKTHDSVTV	NUDT14	31	O95848
KRSHSCKDITDMRSW	KCNH7	981	Q9NS40
VEKWNADHSKSDRMT	GOLGA5	266	Q8TBA6
LMWRHERIKKTSFST	IL17RB	311	Q9NRM6
FKSNSVEMDWVLKHT	HNRNPH2	86	P55795
WLKSSAAMAKAFSTL	OR4K5	226	Q8NGD3
VTMKTAKVAASDWTF	OTC	286	P00480
SEVRDWLASTFTRKM	PDE1A	91	P54750
KSIDDALSTWSLKTM	IQSEC3	411	Q9UPP2
WANKMEALTSKSAAD	P4HA2	61	O15460
HKTWAGVSSKSMKEL	RGL4	331	Q8IZJ4
WKSTSFDRMQSALKT	UPF1	426	Q92900
FLKDSWISSLKVAMR	DNAH1	556	Q9P2D7
IFDTSWVSMKSFLAK	DYNC2H1	3026	Q8NCM8
EKHWTTASRSMSDRK	ICE1	461	Q9Y2F5
RSKTFTTWMVKDLQH	IL6R	261	P08887
SNSEDKSIRVWDMSK	COPA	266	P53621
LSLSKMDFDDERTWT	CENPJ	786	Q9HC77
EDRSKTTNTWVLHMD	FAIM	91	Q9NVQ4
ASNSSMKSSIKWAEE	HAUS3	281	Q68CZ6
MKSSIKWAEESLHSL	HAUS3	286	Q68CZ6
CKRSMRWSNLFTSEK	AGAP7P	221	Q5VUJ5
KDWMPTSELKSETFS	DENND2C	546	Q68D51
KSWMSKHRKTYSTEE	CTSH	36	P09668
LAMAAKVDLSTSTDW	MACROD1	81	Q9BQ69
KFRANASKMLSWDTV	ACOD1	421	A6NK06
MHSSEMKVSSTWLRD	CXorf38	166	Q8TB03
KMDSKKWSTRGSESH	CARMIL1	1036	Q5VZK9
SEKKSDMEWTSSSKI	HLTF	821	Q14527
MRWSHRATVSSVKTD	GPX5	196	O75715
SQKSLWTIKSMSEDE	CEP295	396	Q9C0D2
SMSLLDAHTWTKSRR	DUSP21	126	Q9H596
NKMFTEKATEESWTS	PRIMPOL	231	Q96LW4
WKMPKSEVASSVFSS	OSBPL11	461	Q9BXB4
SRPAYTKKDTMEWHS	ARHGAP20	1011	Q9P2F6
LMWKDSDHFSNKERS	RTKN2	111	Q8IZC4
SSSAWAKGLSDVKMA	SYP	156	P08247
NMAKKSVDIVSSHWD	PLD5	141	Q8N7P1
NGSSWFKTKRMSLSD	TAS2R3	31	Q9NYW6
MTTFFKDTSSLVDWK	TOP6BL	266	Q8N6T0
QDWLSKTEKMVHESS	SYNE1	3186	Q8NF91
KKSRSSWRLTSSEMK	F5	1786	P12259
SWRLTSSEMKKSHEF	F5	1791	P12259
ATGKMWSTATDLEKH	HMGB4	126	Q8WW32
LTFKMESARKAWENS	PRRC2C	2246	Q9Y520
KVTSVKAHSDTWMVV	SIAE	71	Q9HAT2
SLSETTATMLWKSKG	SECISBP2L	231	Q93073
KTDQRWSSTSSSKIM	MRE11	661	P49959
ADDKTVRLWDHATMT	STRAP	161	Q9Y3F4
SLSHSWIFAIKKAEM	TJAP1	121	Q5JTD0
FMFRKSSTSPKWAHD	THRAP3	911	Q9Y2W1
ERMKHDDTTISSWLQ	THOC2	626	Q8NI27
SDSELSTMKKSWGIR	UNC13C	196	Q8NB66
QMKLWEAESKLSFAT	MIS18A	216	Q9NYP9
ERTDMKTLSRKHWSS	THAP9	861	Q9H5L6
HSSSKRRKSMSSWLD	SAGE1	56	Q9NXZ1
ATSKTRMQDFWSLLT	STAG3L4	6	Q8TBR4
MERSWSVKSAAKESL	SREBF2	771	Q12772
ADRMFHSVKSTWESA	WDFY4	2666	Q6ZS81
DVKSSSNRLWMKFVS	TLL2	546	Q9Y6L7
MDAKSLTAWSRTLVT	ZNF10	1	P21506
EMSGKASWSRDVTKI	ZNF648	96	Q5T619
STSMDKTFKVWNAVD	WDR25	266	Q64LD2
NDSSKFKTTESHMDW	UBTF	41	P17480
TKSFMDFGSWERHTK	TFIP11	136	Q9UBB9
TDRASESDTWVKHRM	UBASH3A	336	P57075