Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Calret/calnex	CALR3 CANX	1.49e-05	4	30	2	IPR001580
Domain	Calreticulin	CALR3 CANX	1.49e-05	4	30	2	PF00262
Domain	CALRETICULIN_1	CALR3 CANX	1.49e-05	4	30	2	PS00803
Domain	CALRETICULIN_2	CALR3 CANX	1.49e-05	4	30	2	PS00804
Domain	Calret/calnex_CS	CALR3 CANX	1.49e-05	4	30	2	IPR018124
Domain	Lipase_panc	PNLIPRP2 PNLIPRP3	1.49e-05	4	30	2	IPR002331
Domain	Calreticulin/calnexin_P_dom	CALR3 CANX	2.49e-05	5	30	2	IPR009033
Domain	Lipase_LIPH	PNLIPRP2 PNLIPRP3	1.11e-04	10	30	2	IPR016272
Domain	Lipase	PNLIPRP2 PNLIPRP3	1.11e-04	10	30	2	PF00151
Domain	Lipase_N	PNLIPRP2 PNLIPRP3	1.11e-04	10	30	2	IPR033906
Domain	Lipase/vitellogenin	PNLIPRP2 PNLIPRP3	1.11e-04	10	30	2	IPR013818
Domain	TAG_lipase	PNLIPRP2 PNLIPRP3	1.11e-04	10	30	2	IPR000734
Domain	PLAT	PNLIPRP2 PNLIPRP3	5.14e-04	21	30	2	PF01477
Domain	PLAT	PNLIPRP2 PNLIPRP3	5.14e-04	21	30	2	PS50095
Domain	PLAT/LH2_dom	PNLIPRP2 PNLIPRP3	5.14e-04	21	30	2	IPR001024
Domain	-	PNLIPRP2 PNLIPRP3	5.14e-04	21	30	2	2.60.60.20
Domain	LIPASE_SER	PNLIPRP2 PNLIPRP3	7.91e-04	26	30	2	PS00120
Domain	Protein_kinase_ATP_BS	LIMK2 CSK EIF2AK2 PDPK1	3.01e-03	379	30	4	IPR017441
Domain	PROTEIN_KINASE_ATP	LIMK2 CSK EIF2AK2 PDPK1	5.95e-03	459	30	4	PS00107
Domain	Prot_kinase_dom	LIMK2 CSK EIF2AK2 PDPK1	7.42e-03	489	30	4	IPR000719
Domain	PROTEIN_KINASE_DOM	LIMK2 CSK EIF2AK2 PDPK1	7.63e-03	493	30	4	PS50011
Pathway	REACTOME_DIGESTION_OF_DIETARY_LIPID	PNLIPRP2 PNLIPRP3	6.31e-05	7	25	2	M27069
Pathway	WP_EGFEGFR_SIGNALING	CBLC LIMK2 CSK PDPK1	1.76e-04	162	25	4	M39334
Pubmed	Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src.	HDAC3 CSK	2.16e-06	3	30	2	16532030
Pubmed	A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.	KLK4 CANX	6.50e-05	14	30	2	28174279
Pubmed	Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.	SEMA4C GABRA6	7.50e-05	15	30	2	21122816
Pubmed	The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons.	PDPK1 CANX	8.57e-05	16	30	2	19943849
Pubmed	Plexin-B2 controls the development of cerebellar granule cells.	SEMA4C GABRA6	1.50e-04	21	30	2	17409257
Pubmed	Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.	RPL21 EIF2AK2 ZNF768 CANX	1.86e-04	333	30	4	36779763
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	CSK EIF2AK2 TOP3B ZNF768	2.61e-04	364	30	4	24778252
Pubmed	Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.	RPL21 CSK CANX CYB5R3	4.40e-04	418	30	4	32552912
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	RPL21 EIF2AK2 TOP3B ZNF768 CANX	5.85e-04	807	30	5	22681889
Pubmed	Large-scale structural analysis of the classical human protein tyrosine phosphatome.	CSK PDPK1	7.59e-04	47	30	2	19167335
Pubmed	AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.	RPL21 ZNF768 CANX CYB5R3	7.62e-04	484	30	4	31995728
Interaction	GPC4 interactions	TOP3B HPN PDPK1 CANX	4.82e-06	79	29	4	int:GPC4
Interaction	MOGS interactions	CALR3 TOP3B HPN CANX CYB5R3	8.53e-06	198	29	5	int:MOGS
Interaction	SLC52A3 interactions	CSK TOP3B	1.20e-05	4	29	2	int:SLC52A3
Interaction	AHSG interactions	CSK TOP3B PDPK1 CANX	1.39e-05	103	29	4	int:AHSG
Interaction	PDIA5 interactions	CALR3 CSK TOP3B HPN	1.49e-05	105	29	4	int:PDIA5
Interaction	SLC25A13 interactions	LIMK2 CALR3 CSK TOP3B CANX	3.35e-05	263	29	5	int:SLC25A13
Interaction	GLG1 interactions	CSK HPN PDPK1 CANX	3.68e-05	132	29	4	int:GLG1
Interaction	CDH2 interactions	RPL21 BOC CSK CANX	4.50e-05	139	29	4	int:CDH2
Interaction	MFGE8 interactions	HPN CANX CYB5R3	5.98e-05	53	29	3	int:MFGE8
Interaction	GPC2 interactions	TOP3B HPN	7.15e-05	9	29	2	int:GPC2
Interaction	IGSF6 interactions	CSK CANX	1.09e-04	11	29	2	int:IGSF6
Interaction	RALGPS1 interactions	CSK TOP3B	1.31e-04	12	29	2	int:RALGPS1
Interaction	OVOL1 interactions	HDAC3 TOP3B	1.31e-04	12	29	2	int:OVOL1
Interaction	TOR1A interactions	CALR3 HPN CANX	1.56e-04	73	29	3	int:TOR1A
Interaction	GPC3 interactions	HPN PDPK1 CANX	1.69e-04	75	29	3	int:GPC3
Interaction	ATP5PO interactions	RPL21 CALR3 TOP3B CANX CYB5R3	1.88e-04	379	29	5	int:ATP5PO
Interaction	GRM2 interactions	RPL21 EIF2AK2 ZNF768 CANX CYB5R3	1.92e-04	381	29	5	int:GRM2
Interaction	TMX4 interactions	CSK HPN CANX	2.04e-04	80	29	3	int:TMX4
Interaction	TTC13 interactions	CALR3 CSK CANX	2.04e-04	80	29	3	int:TTC13
Interaction	IL17RD interactions	CSK TOP3B	2.08e-04	15	29	2	int:IL17RD
Interaction	PCYOX1 interactions	CALR3 CANX CYB5R3	2.28e-04	83	29	3	int:PCYOX1
Interaction	A4GALT interactions	TOP3B CANX	2.37e-04	16	29	2	int:A4GALT
Interaction	STK32C interactions	LIMK2 TOP3B CANX	2.62e-04	87	29	3	int:STK32C
Interaction	RGS16 interactions	CSK TOP3B	2.68e-04	17	29	2	int:RGS16
Interaction	DNAH9 interactions	DNAH9 CANX	2.68e-04	17	29	2	int:DNAH9
Cytoband	10q25.3	PNLIPRP2 PNLIPRP3	1.66e-04	29	30	2	10q25.3
Cytoband	2q11.2	SEMA4C COA5	1.03e-03	72	30	2	2q11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr10q25	PNLIPRP2 PNLIPRP3	3.34e-03	131	30	2	chr10q25
Cytoband	Ensembl 112 genes in cytogenetic band chr2q11	SEMA4C COA5	4.51e-03	153	30	2	chr2q11
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	CBLC KLK4 ZNF772 HPN	7.24e-03	1192	30	4	chr19q13
GeneFamily	Lipases\|Arylacetamide deacetylase family	PNLIPRP2 PNLIPRP3	3.22e-04	22	22	2	464
GeneFamily	Proteases, serine	KLK4 HPN	2.64e-03	63	22	2	738
Coexpression	GSE36888_UNTREATED_VS_IL2_TREATED_STAT5_AB_KNOCKIN_TCELL_17H_UP	LIMK2 KREMEN1 FIGNL1 SEMA4C GABRA6	2.01e-06	191	29	5	M8742
Coexpression	GSE10325_BCELL_VS_LUPUS_BCELL_UP	TOP3B ZNF768 HPN SEMA4C	5.98e-05	194	29	4	M3094
Coexpression	GSE17721_0.5H_VS_8H_GARDIQUIMOD_BMDC_DN	BOC KREMEN1 PDPK1 COA5	6.60e-05	199	29	4	M4142
Disease	ovarian cancer (is_marker_for)	HDAC3 KLK4	1.90e-03	68	28	2	DOID:2394 (is_marker_for)
Disease	sleep duration, low density lipoprotein cholesterol measurement	BOC CBLC	3.38e-03	91	28	2	EFO_0004611, EFO_0005271
Disease	prostate cancer (is_implicated_in)	KLK4 PDPK1	5.51e-03	117	28	2	DOID:10283 (is_implicated_in)
Disease	macrophage inflammatory protein 1b measurement	TOPAZ1 TOP3B	7.37e-03	136	28	2	EFO_0008219
Disease	Schizophrenia	HDAC3 KREMEN1 TOP3B GABRA6	9.21e-03	883	28	4	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGKYCGHMYQLTKAP	CBLC	141	Q9ULV8
QKMDCGGGYIKVFPA	CALR3	101	Q96L12
KGYKMDAPDGCPPAV	CSK	401	P41240
DTHPKFPAGGKMSQY	CYB5R3	116	P00387
YHPSMFCAGGGHDQK	KLK4	186	Q9Y5K2
MQCKPYGAGPTEPAH	FIGNL1	356	Q6PIW4
KFGYPTPHGGCQKMD	LCNL1	36	Q6ZST4
CGHLDFYPNGGKHMP	PNLIPRP3	236	Q17RR3
FYPNGGKHMPGCEDL	PNLIPRP3	241	Q17RR3
MFGACYKQPLKPSGS	HHLA3	1	Q9XRX5
GPFMVAGEFKYHPEC	LIMK2	81	P53671
MPGNLGCYKDHGNPP	KREMEN1	116	Q96MU8
VNFPMDGHACPLKFG	GABRA6	161	Q16445
PDVGNFHYGAGHPMK	HDAC3	11	O15379
QIKPKMFCAGYPEGG	HPN	331	P05981
GYPGMKPQQHCPGEL	BOC	946	Q9BWV1
HGPEGFHYKCKMGQK	EIF2AK2	126	P19525
DKTPYTIMFGPDKCG	CANX	181	P27824
KNPHFQGPYTSMGKD	LAS2	166	Q8IYD9
YCHFANGIGEPKYMP	DNAH9	2756	Q9NYC9
EGCPKMGHYADQFKG	PNLIPRP2	321	P54317
KGKEYFPGDQVMSPC	OTOG	951	Q6ZRI0
LYSPVAGQMGKHCGK	FER1L6	741	Q2WGJ9
CKPEMGLPYQGHDSG	SOX17	371	Q9H6I2
GCEEMEGYGPLKAHP	PDPK1	326	O15530
KGKCPYDPAKGHAGL	SEMA4C	156	Q9C0C4
MPKYYEDKPQGGACA	COA5	1	Q86WW8
CYNHPPFRDMKKGMG	TOP3B	691	O95985
GQKPYKCPHCGKAFG	ZNF768	341	Q9H5H4
GTVQKGMPHKCYHGK	RPL21	46	P46778
ENNLPYKPDGGCMHV	TOPAZ1	241	Q8N9V7
MGQKGHKDSLYPCGG	TTC39A	1	Q5SRH9
HPGQKPYMCVLCGKQ	ZNF772	166	Q68DY9