Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled acetylcholine receptor activity	CHRM1 CHRM3 CHRM4	1.30e-07	7	32	3	GO:0016907
GeneOntologyMolecularFunction	G protein-coupled neurotransmitter receptor activity	CHRM1 CHRM3 CHRM4	1.06e-06	13	32	3	GO:0099528
GeneOntologyMolecularFunction	G protein-coupled serotonin receptor activity	CHRM1 CHRM3 CHRM4	5.64e-06	22	32	3	GO:0004993
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRM1 CHRM3 CHRM4	6.48e-06	23	32	3	GO:0015464
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	CHRM1 CHRM3 CHRM4	3.82e-05	41	32	3	GO:0008227
GeneOntologyMolecularFunction	choline transmembrane transporter activity	SLC22A2 SLC44A3	6.92e-05	8	32	2	GO:0015220
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	CHRM1 CHRM3 CHRM4	2.33e-04	75	32	3	GO:0098960
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC6A6 SLC22A2 SLC44A3	3.15e-04	83	32	3	GO:0015101
GeneOntologyMolecularFunction	G protein-coupled receptor activity	CALCR ADGRA2 CHRM1 CHRM3 CHRM4 MRGPRE GPR85	4.15e-04	884	32	7	GO:0004930
GeneOntologyMolecularFunction	neurotransmitter receptor activity	CHRM1 CHRM3 CHRM4	5.44e-04	100	32	3	GO:0030594
GeneOntologyMolecularFunction	phosphatidylinositol phospholipase C activity	CHRM1 CHRM3	7.89e-04	26	32	2	GO:0004435
GeneOntologyMolecularFunction	phospholipase activity	PITPNM3 CHRM1 CHRM3	7.97e-04	114	32	3	GO:0004620
GeneOntologyMolecularFunction	phospholipase C activity	CHRM1 CHRM3	9.83e-04	29	32	2	GO:0004629
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	MRC1 CALCR ADGRA2 CHRM1 CHRM3 CHRM4 MRGPRE GPR85	1.06e-03	1353	32	8	GO:0004888
GeneOntologyMolecularFunction	lipase activity	PITPNM3 CHRM1 CHRM3	1.38e-03	138	32	3	GO:0016298
GeneOntologyMolecularFunction	immunoglobulin binding	AMBP MS4A1	1.52e-03	36	32	2	GO:0019865
GeneOntologyMolecularFunction	sulfur compound transmembrane transporter activity	SLC6A6 SLC22A2	4.29e-03	61	32	2	GO:1901682
GeneOntologyMolecularFunction	serine-type peptidase activity	CTRC TMPRSS15 ACE	4.36e-03	207	32	3	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	CTRC TMPRSS15 ACE	4.66e-03	212	32	3	GO:0017171
GeneOntologyMolecularFunction	organic acid binding	AMBP SLC6A6 CYP4A22	7.68e-03	254	32	3	GO:0043177
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	CHRM1 CHRM3 CHRM4	1.89e-07	8	32	3	GO:0007197
GeneOntologyBiologicalProcess	G protein-coupled serotonin receptor signaling pathway	CHRM1 CHRM3 CHRM4	5.88e-06	23	32	3	GO:0098664
GeneOntologyBiologicalProcess	G protein-coupled acetylcholine receptor signaling pathway	CHRM1 CHRM3 CHRM4	7.62e-06	25	32	3	GO:0007213
GeneOntologyBiologicalProcess	acetylcholine receptor signaling pathway	CHRM1 CHRM3 CHRM4	6.72e-05	51	32	3	GO:0095500
GeneOntologyBiologicalProcess	cellular response to acetylcholine	CHRM1 CHRM3 CHRM4	7.54e-05	53	32	3	GO:1905145
GeneOntologyBiologicalProcess	response to acetylcholine	CHRM1 CHRM3 CHRM4	8.89e-05	56	32	3	GO:1905144
GeneOntologyBiologicalProcess	choline transport	SLC22A2 SLC44A3	1.04e-04	10	32	2	GO:0015871
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	CHRM1 CHRM3 CHRM4	1.15e-04	61	32	3	GO:0007187
GeneOntologyBiologicalProcess	regulation of calcium ion import	TRPV2 MS4A1 ACE	1.15e-04	61	32	3	GO:0090279
GeneOntologyBiologicalProcess	postsynaptic signal transduction	CHRM1 CHRM3 CHRM4	1.66e-04	69	32	3	GO:0098926
GeneOntologyBiologicalProcess	vascular process in circulatory system	SLC6A6 ACE CHRM3 LEP SLC22A2	1.74e-04	344	32	5	GO:0003018
GeneOntologyBiologicalProcess	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	CHRM1 CHRM3	1.80e-04	13	32	2	GO:0007207
GeneOntologyBiologicalProcess	icosanoid transport	ACE LEP SLC22A2	1.96e-04	73	32	3	GO:0071715
GeneOntologyBiologicalProcess	cellular response to mineralocorticoid stimulus	ACE NPAS4	2.10e-04	14	32	2	GO:0071389
GeneOntologyBiologicalProcess	cellular response to oxygen-containing compound	AMBP MRC1 KDM6B ACE CHRM1 CHRM3 CHRM4 LEP NPAS4	2.61e-04	1450	32	9	GO:1901701
GeneOntologyBiologicalProcess	saliva secretion	CHRM1 CHRM3	3.13e-04	17	32	2	GO:0046541
GeneOntologyBiologicalProcess	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	CHRM1 CHRM3 CHRM4	3.18e-04	86	32	3	GO:0007193
GeneOntologyBiologicalProcess	import across plasma membrane	TRPV2 SLC6A6 MS4A1 SLC22A2	4.24e-04	230	32	4	GO:0098739
GeneOntologyBiologicalProcess	calcium ion import	TRPV2 MS4A1 ACE	4.67e-04	98	32	3	GO:0070509
GeneOntologyBiologicalProcess	regulation of vasoconstriction	ACE CHRM3 LEP	4.67e-04	98	32	3	GO:0019229
GeneOntologyBiologicalProcess	positive regulation of cold-induced thermogenesis	TRPV2 KDM6B LEP	5.25e-04	102	32	3	GO:0120162
GeneOntologyBiologicalProcess	negative regulation of D-glucose import	ACE LEP	6.84e-04	25	32	2	GO:0046325
GeneOntologyBiologicalProcess	positive regulation of monoatomic ion transport	TRPV2 MS4A1 CHRM1 LEP	7.32e-04	266	32	4	GO:0043270
GeneOntologyBiologicalProcess	vasoconstriction	ACE CHRM3 LEP	8.63e-04	121	32	3	GO:0042310
GeneOntologyBiologicalProcess	body fluid secretion	CHRM1 CHRM3 SLC22A2	8.63e-04	121	32	3	GO:0007589
GeneOntologyBiologicalProcess	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	CALCR CHRM1 CHRM3 CHRM4	9.59e-04	286	32	4	GO:0007188
GeneOntologyBiologicalProcess	digestive system process	CHRM1 CHRM3 LEP	9.70e-04	126	32	3	GO:0022600
GeneOntologyBiologicalProcess	negative regulation of D-glucose transmembrane transport	ACE LEP	9.87e-04	30	32	2	GO:0010829
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	CALCR ACE ADGRA2 CHRM1 CHRM3 CHRM4 MRGPRE GPR85	1.04e-03	1395	32	8	GO:0007186
GeneOntologyBiologicalProcess	fatty acid transport	ACE LEP SLC22A2	1.11e-03	132	32	3	GO:0015908
GeneOntologyBiologicalProcess	prostaglandin transport	LEP SLC22A2	1.27e-03	34	32	2	GO:0015732
GeneOntologyBiologicalProcess	positive regulation of calcium ion import	TRPV2 MS4A1	1.27e-03	34	32	2	GO:0090280
GeneOntologyBiologicalProcess	lipid biosynthetic process	PITPNM3 ACER3 HACD3 LEP DHCR7 SLC44A3	1.39e-03	813	32	6	GO:0008610
GeneOntologyBiologicalProcess	organic cation transport	SLC6A6 SLC22A2 SLC44A3	1.45e-03	145	32	3	GO:0015695
GeneOntologyBiologicalProcess	regulation of cold-induced thermogenesis	TRPV2 KDM6B LEP	1.66e-03	152	32	3	GO:0120161
GeneOntologyBiologicalProcess	alcohol biosynthetic process	ACER3 LEP DHCR7	1.73e-03	154	32	3	GO:0046165
GeneOntologyBiologicalProcess	cold-induced thermogenesis	TRPV2 KDM6B LEP	1.79e-03	156	32	3	GO:0106106
GeneOntologyBiologicalProcess	regulation of monoatomic ion transport	TRPV2 MS4A1 ACE CHRM1 LEP	1.81e-03	577	32	5	GO:0043269
GeneOntologyBiologicalProcess	digestion	CHRM1 CHRM3 LEP	1.93e-03	160	32	3	GO:0007586
GeneOntologyBiologicalProcess	response to glucocorticoid	CALCR ACE NPAS4	1.93e-03	160	32	3	GO:0051384
GeneOntologyBiologicalProcess	response to mineralocorticoid	ACE NPAS4	2.02e-03	43	32	2	GO:0051385
GeneOntologyCellularComponent	cholinergic synapse	CHRM1 SLC22A2	4.83e-04	22	31	2	GO:0098981
GeneOntologyCellularComponent	presynaptic membrane	CHRM1 CHRM3 CHRM4 SLC22A2	7.16e-04	277	31	4	GO:0042734
GeneOntologyCellularComponent	cell surface	TRPV2 AMBP MRC1 PROM1 MS4A1 ACE ADGRA2	1.00e-03	1111	31	7	GO:0009986
GeneOntologyCellularComponent	microvillus membrane	SLC6A6 PROM1	1.45e-03	38	31	2	GO:0031528
GeneOntologyCellularComponent	brush border	PROM1 TMPRSS15 ACE	1.46e-03	152	31	3	GO:0005903
GeneOntologyCellularComponent	synaptic membrane	SLC6A6 CHRM1 CHRM3 CHRM4 SLC22A2	1.55e-03	583	31	5	GO:0097060
GeneOntologyCellularComponent	postsynaptic density membrane	CHRM1 CHRM3 CHRM4	1.60e-03	157	31	3	GO:0098839
GeneOntologyCellularComponent	basal plasma membrane	SLC6A6 ACE CHRM3 SLC22A2	1.77e-03	354	31	4	GO:0009925
GeneOntologyCellularComponent	basal part of cell	SLC6A6 ACE CHRM3 SLC22A2	2.25e-03	378	31	4	GO:0045178
GeneOntologyCellularComponent	postsynaptic membrane	SLC6A6 CHRM1 CHRM3 CHRM4	2.89e-03	405	31	4	GO:0045211
GeneOntologyCellularComponent	postsynaptic specialization membrane	CHRM1 CHRM3 CHRM4	3.23e-03	201	31	3	GO:0099634
GeneOntologyCellularComponent	axon terminus	CHRM1 CHRM3 CHRM4	3.65e-03	210	31	3	GO:0043679
GeneOntologyCellularComponent	distal axon	TRPV2 CHRM1 CHRM3 CHRM4	3.73e-03	435	31	4	GO:0150034
GeneOntologyCellularComponent	cluster of actin-based cell projections	PROM1 TMPRSS15 ACE	4.32e-03	223	31	3	GO:0098862
GeneOntologyCellularComponent	neuron projection terminus	CHRM1 CHRM3 CHRM4	4.88e-03	233	31	3	GO:0044306
GeneOntologyCellularComponent	apical plasma membrane	SLC6A6 PROM1 SLC22A2 CYP4A22	5.56e-03	487	31	4	GO:0016324
GeneOntologyCellularComponent	actin-based cell projection	SLC6A6 PROM1 ADGRA2	7.94e-03	278	31	3	GO:0098858
Domain	Musac_Ach_rcpt	CHRM1 CHRM3 CHRM4	3.73e-08	5	30	3	IPR000995
Domain	HRM	CALCR ADGRA2	9.19e-04	28	30	2	PF02793
Domain	GPCR_2_secretin-like_CS	CALCR ADGRA2	1.36e-03	34	30	2	IPR017983
Domain	G_PROTEIN_RECEP_F2_1	CALCR ADGRA2	1.87e-03	40	30	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	CALCR ADGRA2	1.87e-03	40	30	2	PS50227
Domain	GPCR_2_extracellular_dom	CALCR ADGRA2	1.87e-03	40	30	2	IPR001879
Domain	G_PROTEIN_RECEP_F2_2	CALCR ADGRA2	2.91e-03	50	30	2	PS00650
Domain	7tm_2	CALCR ADGRA2	2.91e-03	50	30	2	PF00002
Domain	GPCR_Rhodpsn_7TM	CHRM1 CHRM3 CHRM4 MRGPRE GPR85	3.96e-03	670	30	5	IPR017452
Domain	7tm_1	CHRM1 CHRM3 CHRM4 MRGPRE GPR85	4.14e-03	677	30	5	PF00001
Domain	GPCR_2-like	CALCR ADGRA2	4.17e-03	60	30	2	IPR017981
Domain	GPCR_2_secretin-like	CALCR ADGRA2	4.17e-03	60	30	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	CALCR ADGRA2	4.30e-03	61	30	2	PS50261
Domain	G_PROTEIN_RECEP_F1_1	CHRM1 CHRM3 CHRM4 MRGPRE GPR85	4.35e-03	685	30	5	PS00237
Domain	G_PROTEIN_RECEP_F1_2	CHRM1 CHRM3 CHRM4 MRGPRE GPR85	4.52e-03	691	30	5	PS50262
Domain	GPCR_Rhodpsn	CHRM1 CHRM3 CHRM4 MRGPRE GPR85	4.54e-03	692	30	5	IPR000276
Domain	TRYPSIN_SER	CTRC TMPRSS15	9.15e-03	90	30	2	IPR033116
Domain	TRYPSIN_HIS	CTRC TMPRSS15	1.18e-02	103	30	2	IPR018114
Domain	TRYPSIN_SER	CTRC TMPRSS15	1.25e-02	106	30	2	PS00135
Domain	TRYPSIN_HIS	CTRC TMPRSS15	1.27e-02	107	30	2	PS00134
Domain	7TM_GPCR_Srsx	CHRM3 CHRM4	1.39e-02	112	30	2	SM01381
Domain	Peptidase_S1A	CTRC TMPRSS15	1.41e-02	113	30	2	IPR001314
Domain	TRYPSIN_DOM	CTRC TMPRSS15	1.46e-02	115	30	2	PS50240
Domain	Tryp_SPc	CTRC TMPRSS15	1.51e-02	117	30	2	SM00020
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM1 CHRM3 CHRM4	7.81e-08	5	29	3	M27300
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM1 CHRM3 CHRM4	7.81e-08	5	29	3	MM15006
Pathway	WP_MONOAMINE_GPCRS	CHRM1 CHRM3 CHRM4	3.38e-05	31	29	3	MM15871
Pathway	WP_MONOAMINE_GPCRS	CHRM1 CHRM3 CHRM4	4.10e-05	33	29	3	M39585
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	CHRM1 CHRM3 CHRM4	8.51e-05	42	29	3	M5868
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	CHRM1 CHRM3 CHRM4	8.51e-05	42	29	3	MM14971
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	CALCR CHRM1 CHRM3 CHRM4 LEP	2.09e-04	272	29	5	M13380
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC6A6 SLC22A2 SLC44A3	4.97e-04	76	29	3	MM15072
Pathway	REACTOME_TRANSPORT_OF_BILE_SALTS_AND_ORGANIC_ACIDS_METAL_IONS_AND_AMINE_COMPOUNDS	SLC6A6 SLC22A2 SLC44A3	6.67e-04	84	29	3	M27334
Pathway	REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS	SLC6A6 SLC22A2	6.84e-04	19	29	2	MM15107
Pathway	REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS	SLC6A6 SLC22A2	6.84e-04	19	29	2	M27362
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	CHRM1 CHRM3	7.59e-04	20	29	2	M47688
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	CHRM1 CHRM3	8.38e-04	21	29	2	M47689
Pathway	REACTOME_METABOLISM_OF_LIPIDS	PITPNM3 ACER3 HACD3 DHCR7 SLC44A3 CYP4A22	1.41e-03	620	29	6	MM15193
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	CHRM1 CHRM3 CHRM4 GPR85	1.87e-03	260	29	4	M39397
Pathway	WP_GPCRS_NONODORANT	CALCR CHRM1 CHRM3 CHRM4	2.03e-03	266	29	4	MM15843
Pathway	WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION	KDM6B CHRM1	2.47e-03	36	29	2	M39831
Pubmed	Mapping of five subtype genes for muscarinic acetylcholine receptor to mouse chromosomes.	MS4A1 CHRM1 CHRM3 CHRM4	1.39e-09	17	32	4	10549128
Pubmed	Muscarinic receptor subtypes. Physiology and clinical implications.	CHRM1 CHRM3 CHRM4	2.83e-09	4	32	3	2674717
Pubmed	Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes.	CHRM1 CHRM3 CHRM4	2.83e-09	4	32	3	2739737
Pubmed	Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors.	CHRM1 CHRM3 CHRM4	2.83e-09	4	32	3	9603968
Pubmed	Identification of a family of muscarinic acetylcholine receptor genes.	CHRM1 CHRM3 CHRM4	2.83e-09	4	32	3	3037705
Pubmed	Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling.	CHRM1 CHRM3 CHRM4	2.83e-09	4	32	3	15147302
Pubmed	Ciliary activity in the oviduct of cycling, pregnant, and muscarinic receptor knockout mice.	CHRM1 CHRM3 CHRM4	2.83e-09	4	32	3	22302687
Pubmed	Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.	CHRM1 CHRM3 CHRM4	2.83e-09	4	32	3	3443095
Pubmed	M(1)/M(3) and M(2)/M(4) muscarinic receptor double-knockout mice present distinct respiratory phenotypes.	CHRM1 CHRM3 CHRM4	2.83e-09	4	32	3	18206430
Pubmed	Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	20940295
Pubmed	Muscarinic acetylcholine receptor subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	26084221
Pubmed	Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knockout mice.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	15919709
Pubmed	Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	12675128
Pubmed	Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	15913791
Pubmed	Muscarinic acetylcholine receptor subtypes: localization and structure/function.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	8248499
Pubmed	The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	30914695
Pubmed	Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	15661360
Pubmed	Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	24695732
Pubmed	Muscarinic receptors in the prenatal mouse embryo. Comparison of M35-immunohistochemistry with [3H]quinuclidinyl benzylate autoradiography.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	7648406
Pubmed	Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	15574798
Pubmed	Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	11306684
Pubmed	Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activity.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	20197056
Pubmed	Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	12151512
Pubmed	Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells via negative feedback.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	29401598
Pubmed	Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	19213795
Pubmed	The role of muscarinic receptor subtypes in acetylcholine release from urinary bladder obtained from muscarinic receptor knockout mouse.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	18755247
Pubmed	Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	20463237
Pubmed	Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses.	CHRM1 CHRM3 CHRM4	7.07e-09	5	32	3	19940190
Pubmed	Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling.	CHRM1 CHRM3 CHRM4	1.41e-08	6	32	3	31914675
Pubmed	A parasympathetic neurotransmitter induces myoepithelial cell differentiation during salivary gland development.	CHRM1 CHRM3 CHRM4	2.47e-08	7	32	3	35427599
Pubmed	Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.	CHRM1 CHRM3 CHRM4	8.45e-08	10	32	3	10336173
Pubmed	No evidence for association between 19 cholinergic genes and bipolar disorder.	CHRM1 CHRM3 CHRM4	6.79e-07	19	32	3	17373692
Pubmed	Cell type-specific dependence of muscarinic signalling in mouse hippocampal stratum oriens interneurones.	CHRM1 CHRM3	8.20e-07	2	32	2	16322052
Pubmed	Ventilatory pattern and chemosensitivity in M1 and M3 muscarinic receptor knockout mice.	CHRM1 CHRM3	8.20e-07	2	32	2	15122990
Pubmed	Muscarinic cholinoceptor activation by pilocarpine triggers apoptosis in human skin fibroblast cells.	CHRM1 CHRM3	8.20e-07	2	32	2	19927300
Pubmed	M1 receptor-mediated nitric oxide-dependent relaxation unmasked in stomach fundus from M3 receptor knockout mice.	CHRM1 CHRM3	8.20e-07	2	32	2	12538821
Pubmed	M1 muscarinic receptor signaling in mouse hippocampus and cortex.	CHRM1 CHRM3	8.20e-07	2	32	2	12106668
Pubmed	Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization through M3 and M4 muscarinic receptors.	CHRM3 CHRM4	8.20e-07	2	32	2	15263021
Pubmed	CD20-related signaling pathway is differently activated in normal and dystrophic circulating CD133(+) stem cells.	PROM1 MS4A1	8.20e-07	2	32	2	19153665
Pubmed	Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.	CHRM1 CHRM4	8.20e-07	2	32	2	26958838
Pubmed	Distinct pathways of ERK activation by the muscarinic agonists pilocarpine and carbachol in a human salivary cell line.	CHRM1 CHRM3	8.20e-07	2	32	2	18385290
Pubmed	Changes in Membrane Cholesterol Differentially Influence Preferential and Non-preferential Signaling of the M1 and M3 Muscarinic Acetylcholine Receptors.	CHRM1 CHRM3	8.20e-07	2	32	2	24821386
Pubmed	Cholinergic modulation amplifies the intrinsic oscillatory properties of CA1 hippocampal cholecystokinin-positive interneurons.	CHRM1 CHRM3	8.20e-07	2	32	2	21115639
Pubmed	Muscarinic Receptors Expression in the Peripheral Blood Cells Differentiate Dementia with Lewy Bodies from Alzheimer's Disease.	CHRM1 CHRM4	8.20e-07	2	32	2	34806612
Pubmed	Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and double-knockout mice.	CHRM1 CHRM3	8.20e-07	2	32	2	15266016
Pubmed	Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus.	CHRM1 CHRM3	8.20e-07	2	32	2	16319319
Pubmed	Epithelial muscarinic M1 receptors contribute to carbachol-induced ion secretion in mouse colon.	CHRM1 CHRM3	8.20e-07	2	32	2	16405887
Pubmed	Evidence that anti-muscarinic antibodies in Sjögren's syndrome recognise both M3R and M1R.	CHRM1 CHRM3	8.20e-07	2	32	2	18249005
Pubmed	Effects of chronic stress on depressive-like behaviors and JMJD3 expression in the prefrontal cortex and hippocampus of C57BL/6 and ob/ob mice.	KDM6B LEP	8.20e-07	2	32	2	33340793
Pubmed	M1 is a major subtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells.	CHRM1 CHRM3	8.20e-07	2	32	2	23242454
Pubmed	Muscarinic acetylcholine receptor activation blocks long-term potentiation at cerebellar parallel fiber-Purkinje cell synapses via cannabinoid signaling.	CHRM1 CHRM3	8.20e-07	2	32	2	23776234
Pubmed	Long-Term-But Not Short-Term-Plasticity at the Mossy Fiber-CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice.	CHRM1 CHRM3	8.20e-07	2	32	2	37508553
Pubmed	Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of Nippostrongylus brasiliensis through induction of TH2 cytokines.	CHRM1 CHRM3	8.20e-07	2	32	2	27173511
Pubmed	Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus.	CHRM1 CHRM3	8.20e-07	2	32	2	12859343
Pubmed	Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency.	CHRM3 LEP	8.20e-07	2	32	2	17084710
Pubmed	Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia.	CHRM1 CHRM4	8.20e-07	2	32	2	12476323
Pubmed	Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.	CHRM1 CHRM3	8.20e-07	2	32	2	30157420
Pubmed	Cultured neurons from mouse brain reproduce the muscarinic receptor profile of their tissue of origin.	CHRM3 CHRM4	8.20e-07	2	32	2	7874308
Pubmed	Jmjd3-Mediated H3K27me3 Dynamics Orchestrate Brown Fat Development and Regulate White Fat Plasticity.	KDM6B LEP	8.20e-07	2	32	2	26625958
Pubmed	A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).	CHRM1 CHRM3 CHRM4	9.30e-07	21	32	3	15452121
Pubmed	Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells.	CHRM1 CHRM3	2.46e-06	3	32	2	17463038
Pubmed	Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.	CHRM1 CHRM3	2.46e-06	3	32	2	12713643
Pubmed	Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells.	CHRM1 CHRM3	2.46e-06	3	32	2	18272392
Pubmed	Assignment of muscarinic receptor subtypes mediating G-protein modulation of Ca(2+) channels by using knockout mice.	CHRM1 CHRM4	2.46e-06	3	32	2	10485923
Pubmed	Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.	CHRM1 CHRM3	2.46e-06	3	32	2	16956767
Pubmed	Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia.	CHRM1 CHRM3	2.46e-06	3	32	2	24694019
Pubmed	Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice.	CHRM1 CHRM3	2.46e-06	3	32	2	14645675
Pubmed	Effects of muscarinic receptor antagonists on cocaine discrimination in wild-type mice and in muscarinic receptor M1, M2, and M4 receptor knockout mice.	CHRM1 CHRM4	2.46e-06	3	32	2	28442355
Pubmed	Muscarinic receptor knockout mice: role of muscarinic acetylcholine receptors M(2), M(3), and M(4) in carbamylcholine-induced gallbladder contractility.	CHRM3 CHRM4	2.46e-06	3	32	2	11961069
Pubmed	Localization of muscarinic receptors M1R, M2R and M3R in the human colon.	CHRM1 CHRM3	2.46e-06	3	32	2	20146726
Pubmed	CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients.	CHRM1 CHRM3	2.46e-06	3	32	2	24430298
Pubmed	M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice.	CHRM1 CHRM3	2.46e-06	3	32	2	15146045
Pubmed	Exploring the endocannabinoidome in genetically obese (ob/ob) and diabetic (db/db) mice: Links with inflammation and gut microbiota.	TRPV2 LEP	2.46e-06	3	32	2	34606993
Pubmed	Muscarinic M₃ receptors contribute to allergen-induced airway remodeling in mice.	CHRM1 CHRM3	2.46e-06	3	32	2	24156289
Pubmed	M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: Findings obtained with muscarinic-receptor knockout mouse.	CHRM3 CHRM4	2.46e-06	3	32	2	17008557
Pubmed	Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors.	CHRM1 CHRM3	2.46e-06	3	32	2	15933222
Pubmed	Association of genome variations in the renin-angiotensin system with physical performance.	ACE LEP	2.46e-06	3	32	2	23176367
Pubmed	Proliferative actions of muscarinic receptors expressed in macrophages derived from normal and tumor bearing mice.	CHRM1 CHRM3	2.46e-06	3	32	2	18078830
Pubmed	Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling.	CHRM1 CHRM3	2.46e-06	3	32	2	15280370
Pubmed	Association of the Cholinergic Muscarinic M2 Receptor with Autonomic Nervous System Activity in Patients with Schizophrenia on High-Dose Antipsychotics.	CHRM1 CHRM3	2.46e-06	3	32	2	27923235
Pubmed	Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.	CHRM1 CHRM3	2.46e-06	3	32	2	1905013
Pubmed	Intact coupling of M1 receptors and preserved M2 and M4 receptors in the cortex in progressive supranuclear palsy: contrast with other dementias.	CHRM1 CHRM4	2.46e-06	3	32	2	18282687
Pubmed	Paradoxical sleep in mice lacking M3 and M2/M4 muscarinic receptors.	CHRM3 CHRM4	2.46e-06	3	32	2	16110248
Pubmed	Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.	CHRM3 CHRM4	2.46e-06	3	32	2	3272174
Pubmed	Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene.	CHRM1 CHRM3	2.46e-06	3	32	2	2848036
Pubmed	Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice.	CHRM3 CHRM4	2.46e-06	3	32	2	17878406
Pubmed	Quantitative analysis of muscarinic acetylcholine receptor homo- and heterodimerization in live cells: regulation of receptor down-regulation by heterodimerization.	CHRM1 CHRM3	2.46e-06	3	32	2	16368694
Pubmed	M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons.	CHRM1 CHRM3	2.46e-06	3	32	2	19657040
Pubmed	M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes.	CHRM1 CHRM3	2.46e-06	3	32	2	17192665
Pubmed	Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice.	CHRM1 CHRM3	2.46e-06	3	32	2	23397297
Pubmed	M(2) and M(3) muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice.	CHRM1 CHRM3	2.46e-06	3	32	2	15965495
Pubmed	Distinct mixtures of muscarinic receptor subtypes mediate inhibition of noradrenaline release in different mouse peripheral tissues, as studied with receptor knockout mice.	CHRM3 CHRM4	2.46e-06	3	32	2	15965496
Pubmed	Cholinergically stimulated gastric acid secretion is mediated by M(3) and M(5) but not M(1) muscarinic acetylcholine receptors in mice.	CHRM1 CHRM3	2.46e-06	3	32	2	15691866
Pubmed	Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice.	CHRM1 CHRM3	2.46e-06	3	32	2	21335473
Pubmed	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	ACE CHRM1 CHRM3 CHRM4	4.21e-06	118	32	4	19156168
Pubmed	Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.	CHRM1 CHRM3	4.92e-06	4	32	2	8063729
Pubmed	Identification and characterization of muscarinic acetylcholine receptor subtypes expressed in human skin melanocytes.	CHRM1 CHRM4	4.92e-06	4	32	2	11855742
Pubmed	Blockade of M4 muscarinic receptors on striatal cholinergic interneurons normalizes striatal dopamine release in a mouse model of TOR1A dystonia.	CHRM1 CHRM4	4.92e-06	4	32	2	35314320
Pubmed	Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats.	LEP CYP4A22	4.92e-06	4	32	2	10049703
Pubmed	Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis.	CHRM1 CHRM3	4.92e-06	4	32	2	32205868
Interaction	GPRASP1 interactions	CALCR CHRM1 CHRM3 CHRM4	2.86e-06	67	30	4	int:GPRASP1
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	MS4A18 MS4A1 CHRM1	1.78e-03	345	32	3	chr11q12
Cytoband	11q13	CHRM1 NPAS4	3.09e-03	118	32	2	11q13
Cytoband	Ensembl 112 genes in cytogenetic band chr11q13	ACER3 NPAS4 DHCR7	3.85e-03	454	32	3	chr11q13
GeneFamily	Cholinergic receptors muscarinic	CHRM1 CHRM3 CHRM4	2.33e-08	5	25	3	180
GeneFamily	CD molecules\|Membrane spanning 4-domains	MS4A18 MS4A1	2.77e-04	18	25	2	958
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	MRC1 PROM1 MS4A1 ACE	1.95e-03	394	25	4	471
GeneFamily	G protein-coupled receptors, Class A orphans	MRGPRE GPR85	5.17e-03	78	25	2	262
GeneFamily	Solute carriers	SLC6A6 SLC22A2 SLC44A3	1.67e-02	395	25	3	752
Coexpression	BRIDEAU_IMPRINTED_GENES	CALCR DHCR7 SLC22A2	6.86e-05	65	32	3	M2491
Coexpression	BRIDEAU_IMPRINTED_GENES	CALCR DHCR7 SLC22A2	8.56e-05	70	32	3	MM954
Coexpression	GSE21033_CTRL_VS_POLYIC_STIM_DC_1H_DN	CTRC KDM6B CHRM4 DHCR7	9.62e-05	198	32	4	M7716
Coexpression	GSE22527_ANTI_CD3_INVIVO_VS_UNTREATED_MOUSE_TREG_UP	CTRC AMBP ACE CHRM4	9.81e-05	199	32	4	M7710
Coexpression	GSE21379_WT_VS_SAP_KO_TFH_CD4_TCELL_UP	MRC1 PROM1 ADGRA2 GNS	1.00e-04	200	32	4	M7501
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PITPNM3 SLC6A6 ADGRA2 CHRM3	5.52e-06	163	32	4	1feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCell	COPD-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	TRPV2 MRC1 ACER3 CHRM3	8.90e-06	184	32	4	7fd0b227c3750ffb80e41e92c60fcce46656be14
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC6A6 MRC1 ACER3 CHRM3	9.69e-06	188	32	4	d7a9fb5b021e127b8d927658a55a71098d513b5c
ToppCell	Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	TRPV2 MRC1 ACER3 GNS	9.89e-06	189	32	4	c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	TRPV2 MRC1 ACER3 ACE	1.01e-05	190	32	4	6514f00d222eef08c282face7f177259bca62f0e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A6 PROM1 SLC22A2 SLC44A3	1.03e-05	191	32	4	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	Lung_Parenchyma-Control\|Lung_Parenchyma / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TRPV2 MRC1 KDM6B ACER3	1.24e-05	200	32	4	2cb0fba2477d885b62850e473b4b637a5af531a9
ToppCell	Cerebellum-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nrgn_(Inferior_colliculus)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	CHRM1 CHRM3 NPAS4	1.05e-04	128	32	3	9a800beca5cfc7b41f5eed500d45064cfa61c5de
ToppCell	Cerebellum-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nrgn_(Inferior_colliculus)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	CHRM1 CHRM3 NPAS4	1.05e-04	128	32	3	920ede29f3de68e4d08644a1da53849e0c0973fb
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CTRC CALCR MS4A1	1.07e-04	129	32	3	cbeeaa554da971ba2e4c4b82c85a1d070a45abb8
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PROM1 CALCR LEP	1.65e-04	149	32	3	aedbae2dffa1e880e5c6a146b6d5a135e7f54308
ToppCell	5'-Adult-Appendix-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PROM1 CALCR GPR85	1.85e-04	155	32	3	5fabe24a784f0be46040ffc886eabd8d5ce78121
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 GNS GPR85	1.96e-04	158	32	3	6811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCell	Posterior_cortex\|World / BrainAtlas - Mouse McCarroll V32	CHRM1 CHRM3 NPAS4	1.99e-04	159	32	3	18e9fe2efbe0bca7c3990f3b12b6f549e2c1263a
ToppCell	facs-Spleen-nan-3m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ACER3 ACE	2.07e-04	161	32	3	45591addc765760db6029ac19e80573373d1d917
ToppCell	facs-Spleen-nan-3m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ACER3 ACE	2.07e-04	161	32	3	8741b91a62c9a8ce377ef6533d323b65beb93c63
ToppCell	facs-Spleen-nan-3m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ACER3 ACE	2.07e-04	161	32	3	9cf1dcf0e7ca9e35c46c094a6b78f98d1f6b9276
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 GNS GPR85	2.10e-04	162	32	3	d712bc31840ad1523e3dbf884acbb428a8995001
ToppCell	10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PROM1 ACE CHRM3	2.14e-04	163	32	3	edca1d1a345109dbdeb7ee5464faefab1993fdb2
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A6 PROM1 SLC22A2	2.18e-04	164	32	3	382e42701779d12a7948690b3be72d06dd75c8b4
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ACER3 ACE	2.22e-04	165	32	3	11227bff52eed30b80937fdb1968d0b8e6d30365
ToppCell	C_02\|World / shred on cell type and cluster	MS4A18 TMPRSS15 ACE	2.22e-04	165	32	3	a456c2c9ffe8dc91e17cac84ba87b88e016f8e6d
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRC1 ACER3 ACE	2.22e-04	165	32	3	036f9749048e5e50769cc3210339bf4da469215d
ToppCell	droplet-Spleen-nan-18m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNM3 ACER3 ACE	2.26e-04	166	32	3	e841e62cb20235d6233f78f4155fb8c0ffb1ef1b
ToppCell	droplet-Spleen-nan-18m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNM3 ACER3 ACE	2.26e-04	166	32	3	3ca3ddb663644f0e7f70f9b75833bb54cd9191d3
ToppCell	droplet-Spleen-nan-18m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PITPNM3 ACER3 ACE	2.26e-04	166	32	3	f751cbd01d4978ded7755874ab60504f6291afd7
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KDM6B TBC1D8B GPR85	2.30e-04	167	32	3	6c2dade24a88af04b2c90a7e4f8dd7ccea9e94d1
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	KDM6B TBC1D8B GPR85	2.34e-04	168	32	3	d8f485f8459532a2cb0bef899e6569142cf75685
ToppCell	droplet-Spleen-nan-21m-Hematologic-proerythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER3 ACE LEP	2.43e-04	170	32	3	03cb4e508356f85372a588c8d1c6babf2a012683
ToppCell	droplet-Spleen-nan-21m-Hematologic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER3 ACE LEP	2.47e-04	171	32	3	9498c35b2a2c3a339dc8c5d49c8ec20d8ad52753
ToppCell	droplet-Spleen-nan-21m-Hematologic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACER3 ACE LEP	2.47e-04	171	32	3	db544252f98e073e5bb4bec4a110cd58e6434435
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRPV2 MRC1 GNS	2.51e-04	172	32	3	584af6537685cb459bf0fc298e6f46872016c116
ToppCell	Bronchial_Biopsy-Immune-Luminal_Macrophages\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	TRPV2 MRC1 CALCR	2.64e-04	175	32	3	1cf99de391552d4f8dbe2ed5b01fc3b8adca61b6
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMBP PROM1 CALCR	2.69e-04	176	32	3	fb718a6b07aa5d56600263280afa530bcb63db42
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-D_cells_(SST+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CTRC AMBP CALCR	2.69e-04	176	32	3	da5933eb253f13e70296a50a2bb00ad5c19a2d99
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.6.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPV2 MRC1 ACE	2.73e-04	177	32	3	929cd8f530ce001623735da53b7278d02522e2b5
ToppCell	(5)_Glands_mucous\|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	PROM1 CHRM1 CHRM3	2.78e-04	178	32	3	f0f19b0d78f2cc5df4d4c321a953a6e447d5114a
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MRC1 TBC1D8B GNS	2.82e-04	179	32	3	06d412fc096d88de168969466ce422f0ab5553b2
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMBP PROM1 CALCR	2.82e-04	179	32	3	f2e8fc975c30992611630197b79daaeef7c4211d
ToppCell	(5)_Epithelial_cells-(5)_Glands_mucous\|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)	PROM1 CHRM1 CHRM3	2.87e-04	180	32	3	a4118adaf4b09e2ca01b662ed60e7bbf32a24d58
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRPV2 MRC1 GNS	2.87e-04	180	32	3	cc31d2cd06161300b91b17a67bb432b75f0d719b
ToppCell	droplet-Lung-LUNG-30m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 MRC1 GNS	2.91e-04	181	32	3	8fcdab61fad2efd324d2b27c58f5a594f1dc15de
ToppCell	5'-GW_trimst-1-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMBP DHCR7 SLC44A3	2.91e-04	181	32	3	c7a220891567c7539ad5a9ac9db375f0de08ea00
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRPV2 MRC1 GNS	2.96e-04	182	32	3	94d061b7b5ebbfc564c644bc8b2d52341927145d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 PROM1 KDM6B	2.96e-04	182	32	3	ef65b095f4240d61cfd4a59aec19d72d324dba1d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 PROM1 KDM6B	2.96e-04	182	32	3	97a805783a1f2b055c21307db250e3688674eff3
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPV2 MRC1 GNS	2.96e-04	182	32	3	3dec003bad0f3716cf8163861a9d4302a7d6df8c
ToppCell	droplet-Thymus-nan-18m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP PROM1 ADGRA2	2.96e-04	182	32	3	f6717e97e87513384149800c9fd8dea821ab9393
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 MRC1 GNS	2.96e-04	182	32	3	be48ce85991bceeff938ba080e6bf9cc62176b05
ToppCell	droplet-Thymus-nan-18m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP PROM1 ADGRA2	2.96e-04	182	32	3	c33b0d532822186a1e8e645500347972468718c0
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AMBP PROM1 SLC44A3	3.01e-04	183	32	3	2df1611c8acccb2a6f233d3d68bd9df2381a7278
ToppCell	droplet-Lung-nan-3m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 MRC1 GNS	3.01e-04	183	32	3	ec3c05b9ce1e0fbb720e0dea41f1e28fd3fd878f
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRPV2 MRC1 GNS	3.06e-04	184	32	3	8e5fc2bdd3071e782aa8c56b8a39f8ea8f03f623
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC6A6 GNS LEP	3.06e-04	184	32	3	e343dd7777a29048e3f12a939f7f782b8b7b4fea
ToppCell	droplet-Lung-nan-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 MRC1 GNS	3.06e-04	184	32	3	3261d767d5e3d9e9fbac22ad73ca14e44beed89c
ToppCell	facs-Bladder-nan-18m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PROM1 KDM6B NPAS4	3.11e-04	185	32	3	3e00879466e626aa8604efecfc4678d64f54dbfc
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 MRC1 GNS	3.11e-04	185	32	3	afbb88325e4a81c15ac1d0a004e3e1f4ba2ee87b
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 MRC1 GNS	3.11e-04	185	32	3	775b72319ef6acffd2c9a74293b9c1bccea33f42
ToppCell	Control-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	TRPV2 ACER3 CHRM3	3.11e-04	185	32	3	85cb81759589a26d83676cffbf2bc37399683c10
ToppCell	facs-Bladder-nan-18m-Epithelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PROM1 KDM6B NPAS4	3.11e-04	185	32	3	3dc5812c961ff209f197ff4cbfb90009c0537550
ToppCell	droplet-Bladder-Unstain-18m-Endothelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPV2 PROM1 ACE	3.16e-04	186	32	3	e3a14f3ccadbf3211822c67b8956ee01f563307a
ToppCell	droplet-Lung-nan-21m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 MRC1 GNS	3.16e-04	186	32	3	8f77e552e613b6e124443c7f6ef5c1316a5ff8db
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	TRPV2 MRC1 ACE	3.16e-04	186	32	3	ddfadd43efeac3b3e6b7062590cc2b8f2f2db2ab
ToppCell	droplet-Lung-nan-21m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 MRC1 GNS	3.16e-04	186	32	3	f1aa0c58336d23bcbe52a59e7af954d20085bdb6
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_immature-Tip-like-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ACE ADGRA2 GPR85	3.16e-04	186	32	3	a906020a8df6fcca474b278f746c553b177a56b4
ToppCell	21-Trachea-Epithelial-Goblet-like_secretory\|Trachea / Age, Tissue, Lineage and Cell class	PROM1 ACE CHRM3	3.16e-04	186	32	3	f8cddad28896f0edf10a8645fa49a011b22b120d
ToppCell	(8)_CD34_progenitor\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PROM1 MS4A1 CHRM3	3.16e-04	186	32	3	e69a986b8618effd61875fda528a2e44aab11868
ToppCell	(8)_CD34_progenitor\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PROM1 MS4A1 CHRM3	3.16e-04	186	32	3	943c604a7cd873faf510096d094100512ba2d6bc
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|lymph-node_spleen / Manually curated celltypes from each tissue	TBC1D8B ADGRA2 GNS	3.21e-04	187	32	3	3c10b8501226c69d71bcd99dc1c064a3c2154f87
ToppCell	SMG-Goblet\|World / shred by cell class for bronchial biopsy	PROM1 TBC1D8B CHRM3	3.21e-04	187	32	3	5178118bdec91495253c88f58fd908cf831de7ef
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ACE CHRM1 CHRM3	3.26e-04	188	32	3	366a2d59b9c81d8a7659749f9c07efa46b49a39a
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 PROM1 GNS	3.31e-04	189	32	3	98f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 MRC1 GNS	3.31e-04	189	32	3	287e59104687fe1665232c52993889f0f2c97f17
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HACD3 ADGRA2 SLC22A2	3.31e-04	189	32	3	8e583ec4df0f5b79ce5211cc99ecd8616d180bde
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC6A6 MRC1 GNS	3.31e-04	189	32	3	b2542b6fcf7bc10d29158d42b03182a939ff135a
ToppCell	droplet-Lung-LUNG-1m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 MRC1 GNS	3.31e-04	189	32	3	6d24414ac6bd4f03f7a5ad3a6eba51d549a7b112
ToppCell	droplet-Heart-HEART-1m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A6 MS4A18 PROM1	3.31e-04	189	32	3	4225bbff4037eecc93a12abad3a38dd04b1e22be
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PROM1 SLC22A2 SLC44A3	3.31e-04	189	32	3	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	droplet-Heart-nan-3m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HACD3 ADGRA2 SLC22A2	3.31e-04	189	32	3	fb2253b8463d08b3d28e952a31a23dea2c2d986b
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MRC1 PROM1 GNS	3.31e-04	189	32	3	f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCell	Control-Myeloid-Macrophage_Alveolar\|Control / Disease state, Lineage and Cell class	TRPV2 ACER3 CHRM3	3.31e-04	189	32	3	937e876122bc4b94372a4104e9c1a9068c232018
ToppCell	IPF-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	TRPV2 ACER3 CHRM3	3.36e-04	190	32	3	2592765016f291565697265800a232b2edef3792
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC6A6 MRC1 GNS	3.36e-04	190	32	3	da58227565ad6a690828dd8554dd3670222f8582
ToppCell	IPF-Myeloid-Macrophage_Alveolar\|IPF / Disease state, Lineage and Cell class	TRPV2 MRC1 ACER3	3.36e-04	190	32	3	e539ebc0f4c5ee5dba86c614387be7d91338ad47
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ACE ADGRA2 CHRM3	3.36e-04	190	32	3	d0297d678498e346e56cf95fe9e3db7d3ad3b837
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRPV2 MRC1 ACER3	3.41e-04	191	32	3	723dc09607e791e9517a22c6482d6cd6b07ce1d6
ToppCell	Control-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	TRPV2 ACER3 CHRM3	3.41e-04	191	32	3	a7bb8aba9c59c037d995a77928cc7b4d5cbb82b9
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D175\|Adult / Lineage, Cell type, age group and donor	SLC6A6 MRC1 ACER3	3.46e-04	192	32	3	733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell	368C-Myeloid-Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TRPV2 MRC1 ACE	3.52e-04	193	32	3	c8883731567d0def96e4105dc34b995d1275ddf4
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	SLC6A6 MRC1 ACER3	3.52e-04	193	32	3	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ACE ADGRA2 GPR85	3.52e-04	193	32	3	3f8280ef849d95b2fcea5e6824b95a07febc96d0
ToppCell	IPF-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	TRPV2 MRC1 ACER3	3.52e-04	193	32	3	03a43b6d235fd47488a6a61efc311a34b232c0f4
ToppCell	normal_Lung\|World / Location, Cell class and cell subclass	TRPV2 MRC1 ACER3	3.57e-04	194	32	3	affae83d7f982d18117f5b95705f09809f304b0b
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ACE ADGRA2 GPR85	3.57e-04	194	32	3	ea5e1bc8d9e27cabfe1fb833ca47ec0893593b12
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC6A6 MRC1 ACER3	3.57e-04	194	32	3	69cf7c989ac355c459db13f9d4267b55adc3c174
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage\|367C / Donor, Lineage, Cell class and subclass (all cells)	TRPV2 MRC1 ACER3	3.57e-04	194	32	3	40c91ed945bd5990a0dbf2090d37a660b19aaab2
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ACE ADGRA2 GPR85	3.57e-04	194	32	3	cceb7c88492bb6cd531e1c2651638da1ddf30931
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC6A6 MRC1 ACER3	3.62e-04	195	32	3	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	LAM-Myeloid-Macrophage\|LAM / Condition, Lineage and Cell class	TRPV2 MRC1 ACER3	3.62e-04	195	32	3	85abe51e47b567e6edcadfbe8cf02c2f2f0bb133
ToppCell	Macrophages-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	MRC1 ACE GNS	3.62e-04	195	32	3	eb104f3bb08ab9eca31273c0523a5c90de1f30a9
Drug	Scopolamine Derivatives	CHRM1 CHRM3 CHRM4 SLC22A2	1.40e-11	5	31	4	ctd:D012602
Drug	(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride	CHRM1 CHRM3 CHRM4	2.29e-09	3	31	3	ctd:D008455
Drug	furtrethonium	CHRM1 CHRM3 CHRM4	9.13e-09	4	31	3	ctd:C028530
Drug	Hyoscyamine	CHRM1 CHRM3 CHRM4	9.13e-09	4	31	3	DB00424
Drug	Procyclidine	CHRM1 CHRM3 CHRM4	9.13e-09	4	31	3	DB00387
Drug	5-methylfurtrethonium	CHRM1 CHRM3 CHRM4	9.13e-09	4	31	3	ctd:C008446
Drug	WIN 62577	CHRM1 CHRM3 CHRM4	9.13e-09	4	31	3	ctd:C086110
Drug	WIN 51708	CHRM1 CHRM3 CHRM4	9.13e-09	4	31	3	ctd:C086111
Drug	Tropicamide	CHRM1 CHRM3 CHRM4	9.13e-09	4	31	3	DB00809
Drug	Atropine	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	DB00572
Drug	Fesoterodine	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	DB06702
Drug	Darifenacin	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	DB00496
Drug	Metixene	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	DB00340
Drug	Trihexyphenidyl	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	DB00376
Drug	Solifenacin	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	DB01591
Drug	5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	ctd:C568516
Drug	Pipecuronium	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	ctd:D017300
Drug	N-Methylscopolamine	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	ctd:D019832
Drug	Tolterodine	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	DB01036
Drug	Cryptenamine	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	DB00785
Drug	Homatropine Methylbromide	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	DB00725
Drug	Quinuclidinyl Benzilate	CHRM1 CHRM3 CHRM4	2.28e-08	5	31	3	ctd:D011813
Drug	Gallamine Triethiodide	CHRM1 CHRM3 CHRM4	4.56e-08	6	31	3	ctd:D005703
Drug	brucine N-oxide	CHRM1 CHRM3 CHRM4	4.56e-08	6	31	3	ctd:C083067
Drug	Brompheniramine	CHRM1 CHRM3 CHRM4	4.56e-08	6	31	3	DB00835
Drug	Benzquinamide	CHRM1 CHRM3 CHRM4	4.56e-08	6	31	3	DB00767
Drug	Scopolamine	CHRM1 CHRM3 CHRM4	4.56e-08	6	31	3	DB00747
Drug	Crotalid Venoms	CHRM1 CHRM3 CHRM4	4.56e-08	6	31	3	ctd:D003435
Drug	Tiotropium Bromide	CHRM1 CHRM3 CHRM4	7.97e-08	7	31	3	ctd:D000069447
Drug	AM 1241	CHRM1 CHRM3 CHRM4	1.27e-07	8	31	3	ctd:C439263
Drug	Maprotiline	CHRM1 CHRM3 CHRM4	1.27e-07	8	31	3	DB00934
Drug	Paroxetine	CHRM1 CHRM3 CHRM4	1.27e-07	8	31	3	DB00715
Drug	oxotremorine M	CHRM1 CHRM3 CHRM4	1.27e-07	8	31	3	ctd:C042743
Drug	Bethanechol	CHRM1 CHRM3 CHRM4	2.72e-07	10	31	3	ctd:D018723
Drug	Promethazine	CHRM1 CHRM3 CHRM4	2.72e-07	10	31	3	DB01069
Drug	Strychnine	CHRM3 CHRM4 SLC22A2	2.72e-07	10	31	3	ctd:D013331
Drug	Imipramine	CHRM1 CHRM3 CHRM4	3.74e-07	11	31	3	DB00458
Drug	Pancuronium	CHRM1 CHRM3 CHRM4	3.74e-07	11	31	3	ctd:D010197
Drug	rocuronium	CHRM1 CHRM3 CHRM4	3.74e-07	11	31	3	ctd:C061870
Drug	Nortriptyline	CHRM1 CHRM3 CHRM4	4.99e-07	12	31	3	DB00540
Drug	Chlorprothixene	CHRM1 CHRM3 CHRM4	4.99e-07	12	31	3	DB01239
Drug	Vecuronium Bromide	CHRM1 CHRM3 CHRM4	4.99e-07	12	31	3	ctd:D014673
Drug	Desipramine	CHRM1 CHRM3 CHRM4	6.48e-07	13	31	3	DB01151
Drug	Promazine	CHRM1 CHRM3 CHRM4	8.23e-07	14	31	3	DB00420
Drug	methoctramine	CHRM1 CHRM3 CHRM4	8.23e-07	14	31	3	ctd:C054938
Drug	Propiomazine	CHRM1 CHRM3 CHRM4	8.23e-07	14	31	3	DB00777
Drug	Nicardipine	CHRM1 CHRM3 CHRM4	8.23e-07	14	31	3	DB00622
Drug	PGW5 compound	CHRM1 CHRM3 CHRM4	1.53e-06	17	31	3	ctd:C000593032
Drug	Isopropamide	CHRM3 CHRM4	1.79e-06	2	31	2	DB01625
Drug	Cevimeline	CHRM1 CHRM3	1.79e-06	2	31	2	DB00185
Drug	Mepenzolate	CHRM1 CHRM3	1.79e-06	2	31	2	DB04843
Drug	1-deoxyglucosamine	GNS LEP	1.79e-06	2	31	2	CID000169430
Drug	Amitriptyline	CHRM1 CHRM3 CHRM4	1.84e-06	18	31	3	DB00321
Drug	Methotrimeprazine	CHRM1 CHRM3 CHRM4	2.18e-06	19	31	3	DB01403
Drug	Doxepin	CHRM1 CHRM3 CHRM4	2.56e-06	20	31	3	DB01142
Drug	brucine	CHRM1 CHRM3 CHRM4	3.46e-06	22	31	3	ctd:C083806
Drug	Olanzapine	CHRM1 CHRM3 CHRM4	5.15e-06	25	31	3	DB00334
Drug	Ziprasidone	CHRM1 CHRM3 CHRM4	5.15e-06	25	31	3	DB00246
Drug	Aripiprazole	CHRM1 CHRM3 CHRM4	5.15e-06	25	31	3	DB01238
Drug	Anisotropine Methylbromide	CHRM1 CHRM3	5.38e-06	3	31	2	DB00517
Drug	Tridihexethyl	CHRM1 CHRM3	5.38e-06	3	31	2	DB00505
Drug	Methylscopolamine	CHRM1 CHRM3	5.38e-06	3	31	2	DB00462
Drug	Ipratropium bromide	CHRM1 CHRM3	5.38e-06	3	31	2	DB00332
Drug	Oxyphencyclimine	CHRM1 CHRM3	5.38e-06	3	31	2	DB00383
Drug	bromomethane;[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-propylpentanoate	CHRM1 CHRM3	5.38e-06	3	31	2	CID011954288
Drug	Tiotropium	CHRM1 CHRM3	5.38e-06	3	31	2	DB01409
Drug	Diphenidol	CHRM1 CHRM3	5.38e-06	3	31	2	DB01231
Drug	Pilocarpine	CHRM1 CHRM3	5.38e-06	3	31	2	DB01085
Drug	Oxybutynin	CHRM1 CHRM3	5.38e-06	3	31	2	DB01062
Drug	(1-(2,2-diphenyl-(1,3)dioxolan-4-yl)-ethyl)-dimethyl-amine	CHRM1 CHRM3	5.38e-06	3	31	2	ctd:C425227
Drug	oxyphencyclimine	CHRM1 CHRM3	5.38e-06	3	31	2	CID000004642
Drug	Clozapine	CHRM1 CHRM3 CHRM4	5.82e-06	26	31	3	DB00363
Drug	Quetiapine	CHRM1 CHRM3 CHRM4	5.82e-06	26	31	3	DB01224
Drug	M /T	AMBP ACE LEP	6.54e-06	27	31	3	CID000208657
Drug	Acetylcholine	CHRM1 CHRM3 CHRM4 LEP	6.92e-06	91	31	4	ctd:D000109
Drug	oxybutynin	CHRM1 CHRM3 LEP	7.32e-06	28	31	3	CID000004634
Drug	Atropine	CHRM1 CHRM3 CHRM4 SLC22A2	7.54e-06	93	31	4	ctd:D001285
Drug	Disopyramide	CHRM1 CHRM3	1.07e-05	4	31	2	DB00280
Drug	Botiacrine	CHRM1 CHRM3	1.07e-05	4	31	2	CID000071202
Drug	AC1L1J28	CTRC ADGRA2 GNS	1.21e-05	33	31	3	CID000004834
Drug	Sudan II	PROM1 MS4A1 LEP GPR85	1.63e-05	113	31	4	CID005354447
Drug	Succinylcholine	CHRM1 CHRM3	1.79e-05	5	31	2	DB00202
Drug	xanomeline	CHRM1 CHRM4	1.79e-05	5	31	2	ctd:C075257
Drug	eucatropine	CHRM1 CHRM3	1.79e-05	5	31	2	CID000007534
Drug	bexarotene	CTRC SLC6A6 MRC1 PROM1 DHCR7 CYP4A22	2.37e-05	437	31	6	ctd:C095105
Drug	Nsc34399	CHRM1 CHRM3	2.68e-05	6	31	2	CID000003622
Drug	Cyproheptadine	CHRM1 CHRM3	2.68e-05	6	31	2	DB00434
Drug	Dactil	CHRM1 CHRM3	2.68e-05	6	31	2	CID000004839
Drug	4-diphenylacetoxy-1,1-dimethylpiperidinium	CHRM1 CHRM3	2.68e-05	6	31	2	ctd:C042375
Drug	CHF-1024	AMBP ACE	2.68e-05	6	31	2	CID000038004
Drug	olanzapine	CHRM1 CHRM3 LEP GPR85	2.75e-05	129	31	4	CID000004585
Drug	cholesta-5,24-dien-3beta-ol	SLC6A6 DHCR7 GPR85	3.12e-05	45	31	3	CID000009401
Drug	promethazine	PROM1 CHRM1 CHRM3	3.33e-05	46	31	3	CID000004927
Drug	Tolterodine Tartrate	CHRM3 SLC22A2	3.75e-05	7	31	2	ctd:D000068737
Drug	Ym 21095	CTRC ACE	3.75e-05	7	31	2	CID000128978
Drug	Pilocarpine	SLC6A6 CHRM1 CHRM3 CHRM4 SLC22A2	3.86e-05	285	31	5	ctd:D010862
Drug	Hydrocarbons, Chlorinated	CHRM1 CHRM3 CHRM4	4.04e-05	49	31	3	ctd:D006843
Drug	zotepine	CHRM1 CHRM3 LEP	4.04e-05	49	31	3	CID000005736
Drug	X x 5	AMBP ACE	5.00e-05	8	31	2	CID000448281
Drug	cadralazine	CTRC ACE	5.00e-05	8	31	2	CID000002515
Disease	pyelonephritis (is_marker_for)	AMBP ACE	2.09e-05	7	30	2	DOID:11400 (is_marker_for)
Disease	Chronic schizophrenia	ACE LEP	3.58e-05	9	30	2	C0221765
Disease	chronic obstructive pulmonary disease (is_implicated_in)	ACE CHRM3 LEP	3.61e-05	63	30	3	DOID:3083 (is_implicated_in)
Disease	acute kidney failure (is_implicated_in)	AMBP SLC22A2	4.47e-05	10	30	2	DOID:3021 (is_implicated_in)
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	ACE CYP4A22	5.46e-05	11	30	2	DOID:0110861 (biomarker_via_orthology)
Disease	adult respiratory distress syndrome (is_implicated_in)	AMBP LEP	6.55e-05	12	30	2	DOID:11394 (is_implicated_in)
Disease	osteoporosis (implicated_via_orthology)	ACE LEP	1.69e-04	19	30	2	DOID:11476 (implicated_via_orthology)
Disease	asthma (is_marker_for)	AMBP CHRM3 LEP	2.84e-04	126	30	3	DOID:2841 (is_marker_for)
Disease	Endogenous Hyperinsulinism	MRC1 LEP	3.20e-04	26	30	2	C1257963
Disease	Exogenous Hyperinsulinism	MRC1 LEP	3.20e-04	26	30	2	C1257964
Disease	Compensatory Hyperinsulinemia	MRC1 LEP	3.20e-04	26	30	2	C1257965
Disease	acute kidney failure (implicated_via_orthology)	ACE SLC22A2	3.45e-04	27	30	2	DOID:3021 (implicated_via_orthology)
Disease	Hyperinsulinism	MRC1 LEP	3.72e-04	28	30	2	C0020459
Disease	Cone-Rod Dystrophy 2	PITPNM3 PROM1	3.99e-04	29	30	2	C3489532
Disease	osteoporosis (is_implicated_in)	CALCR LEP	4.56e-04	31	30	2	DOID:11476 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GYWPLGAVVCDLWLA	CHRM4	96	P08173
YGKWYNLAIGSTCPW	AMBP	41	P02760
WVYPWLRGLGYTSLG	ACER3	166	Q9NUN7
DWWYLRTKYQGICPP	ACE	491	P12821
YCWLVWRPSLGAFYI	ADGRA2	916	Q96PE1
WYYLLGWGFPLVPTT	CALCR	261	P30988
IPKTFWNLGYWLCYI	CHRM3	521	P20309
IYAPICVTVWYPLWG	MS4A1	76	P11836
LGWGDCVWLPYLYTL	DHCR7	306	Q9UBM7
WLRYTLWIPLYPLGC	HACD3	276	Q9P035
WPWVVGLYYGGRLLC	TMPRSS15	796	P98073
DYLTGSWWPILDDLY	KDM6B	1431	O15054
LCGFLWLWPYLFYVQ	LEP	6	P41159
LPFGIYWLSRNLLWY	MRGPRE	231	Q86SM8
WAWIYCLLYSEGPEG	NPAS4	291	Q8IUM7
KDYPCYVTGWGRLWT	CTRC	151	Q99895
CPYWIWGGKVRVQLY	CYP4A22	86	Q5TCH4
PETLWELGYWLCYVN	CHRM1	396	P11229
WLSGYPLWGGLSYIV	MS4A18	186	Q3C1V0
GLEHVPLGWSYWYAL	GNS	161	P15586
TLWGPYLVACYWRVF	GPR85	296	P60893
GLLFVCGVLWWLYYD	SLC44A3	251	Q8N4M1
FLLYYWCIPESPRWL	SLC22A2	276	O15244
GYWADRGCEWPLGYI	MRC1	471	P22897
YVYPNWAIGLGWSLA	SLC6A6	536	P31641
DSYWWLGGLVICSLL	PROM1	431	O43490
ELYWLCGFRSYWPLG	PRO0255	6	Q9UI72
SYWKGRVPCQGWLYL	TBC1D8B	166	Q0IIM8
LGGIYLLVGQLWYFW	TRPV2	441	Q9Y5S1
WWGSKRIDYALYCPD	PITPNM3	546	Q9BZ71
YVWSFWLLAPGRALY	TMEM208	121	Q9BTX3
VYILYGILWLTWSAC	TMEM87B	226	Q96K49
LGYVLYGECQEVLWW	TMEM42	116	Q69YG0