Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	heparan sulfate 6-O-sulfotransferase activity	HS6ST2 HS6ST1	6.01e-05	3	90	2	GO:0017095
GeneOntologyMolecularFunction	apolipoprotein binding	LRP1 LRP4 LRP6	9.55e-05	20	90	3	GO:0034185
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRNA6 HRH4 CHRNB4	1.47e-04	23	90	3	GO:0015464
GeneOntologyMolecularFunction	coreceptor activity	LRP1 LRP4 LRP6 LRP5	3.14e-04	72	90	4	GO:0015026
GeneOntologyMolecularFunction	translation termination factor activity	MTRF1 GSPT1	4.16e-04	7	90	2	GO:0008079
GeneOntologyMolecularFunction	translation release factor activity	MTRF1 GSPT1	4.16e-04	7	90	2	GO:0003747
GeneOntologyBiologicalProcess	regulation of mitophagy	VPS13C AMBRA1 HTT FBXW7	2.14e-05	38	89	4	GO:1901524
GeneOntologyBiologicalProcess	cellular response to oxygen-containing compound	MPV17 MRC1 CHRNA6 MLXIPL PTPRF FFAR2 GLP1R LRP1 LRP6 LRP5 HRH4 PRPF8 STAT1 KMO CHRNB4 RYR3 HTT STAT5B	3.97e-05	1450	89	18	GO:1901701
GeneOntologyBiologicalProcess	regulation of autophagy of mitochondrion	VPS13C AMBRA1 HTT FBXW7	4.22e-05	45	89	4	GO:1903146
GeneOntologyBiologicalProcess	neuronal stem cell division	FUT9 ULK4	5.51e-05	3	89	2	GO:0036445
Domain	Ldl_recept_b	LRP1 LRP4 LRP6 LRP5	4.44e-07	14	88	4	PF00058
Domain	LDLRB	LRP1 LRP4 LRP6 LRP5	4.44e-07	14	88	4	PS51120
Domain	LY	LRP1 LRP4 LRP6 LRP5	6.04e-07	15	88	4	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP4 LRP6 LRP5	6.04e-07	15	88	4	IPR000033
Domain	LDLR_class-A_CS	LRP1 LRP4 LRP6 LRP5 CFI	1.20e-06	40	88	5	IPR023415
Domain	Ldl_recept_a	LRP1 LRP4 LRP6 LRP5 CFI	2.18e-06	45	88	5	PF00057
Domain	-	LRP1 LRP4 LRP6 LRP5 CFI	2.44e-06	46	88	5	4.10.400.10
Domain	LDLRA_1	LRP1 LRP4 LRP6 LRP5 CFI	3.02e-06	48	88	5	PS01209
Domain	LDLRA_2	LRP1 LRP4 LRP6 LRP5 CFI	3.35e-06	49	88	5	PS50068
Domain	LDrepeatLR_classA_rpt	LRP1 LRP4 LRP6 LRP5 CFI	3.35e-06	49	88	5	IPR002172
Domain	LDLa	LRP1 LRP4 LRP6 LRP5 CFI	3.35e-06	49	88	5	SM00192
Domain	LRP5/6	LRP6 LRP5	2.19e-05	2	88	2	IPR017049
Domain	-	LRP1 LRP4 LRP6 LRP5	3.34e-05	39	88	4	2.120.10.30
Domain	6-blade_b-propeller_TolB-like	LRP1 LRP4 LRP6 LRP5	6.45e-05	46	88	4	IPR011042
Domain	Heparan_SO4-6-sulfoTrfase	HS6ST2 HS6ST1	6.56e-05	3	88	2	IPR010635
Domain	PTPc_motif	MTMR7 PTPRF MTMR1 PTPRU	1.72e-04	59	88	4	SM00404
Domain	Tyr_Pase_cat	MTMR7 PTPRF MTMR1 PTPRU	1.72e-04	59	88	4	IPR003595
Domain	EGF_1	HGFAC HYAL3 LRP1 LRP4 LRP6 LRP5 USH2A	2.02e-04	255	88	7	PS00022
Domain	EGF	HGFAC LRP1 LRP4 LRP6 LRP5	3.23e-04	126	88	5	PF00008
Domain	Tyr_Pase_AS	MTMR7 PTPRF MTMR1 PTPRU	3.91e-04	73	88	4	IPR016130
Domain	STAT_TF_prot_interaction	STAT1 STAT5B	4.54e-04	7	88	2	IPR013799
Domain	STAT_TF_DNA-bd_sub	STAT1 STAT5B	4.54e-04	7	88	2	IPR012345
Domain	STAT	STAT1 STAT5B	4.54e-04	7	88	2	IPR001217
Domain	STAT_TF_coiled-coil	STAT1 STAT5B	4.54e-04	7	88	2	IPR015988
Domain	-	STAT1 STAT5B	4.54e-04	7	88	2	2.60.40.630
Domain	STAT_int	STAT1 STAT5B	4.54e-04	7	88	2	SM00964
Domain	STAT_TF_DNA-bd	STAT1 STAT5B	4.54e-04	7	88	2	IPR013801
Domain	STAT_bind	STAT1 STAT5B	4.54e-04	7	88	2	PF02864
Domain	STAT_int	STAT1 STAT5B	4.54e-04	7	88	2	PF02865
Domain	-	STAT1 STAT5B	4.54e-04	7	88	2	1.10.532.10
Domain	STAT_alpha	STAT1 STAT5B	4.54e-04	7	88	2	PF01017
Domain	-	STAT1 STAT5B	4.54e-04	7	88	2	1.20.1050.20
Domain	IQ	IQCF5 RASGRF2 ASPM MYO1B	5.81e-04	81	88	4	SM00015
Domain	STAT_TF_alpha	STAT1 STAT5B	6.03e-04	8	88	2	IPR013800
Domain	TYR_PHOSPHATASE_1	MTMR7 PTPRF MTMR1 PTPRU	7.28e-04	86	88	4	PS00383
Domain	TYR_PHOSPHATASE_2	MTMR7 PTPRF MTMR1 PTPRU	7.60e-04	87	88	4	PS50056
Domain	TYR_PHOSPHATASE_dom	MTMR7 PTPRF MTMR1 PTPRU	7.60e-04	87	88	4	IPR000387
Domain	EGF_3	HGFAC HYAL3 LRP1 LRP4 LRP6 LRP5	8.54e-04	235	88	6	PS50026
Domain	EGF	HGFAC HYAL3 LRP1 LRP4 LRP6 LRP5	8.54e-04	235	88	6	SM00181
Domain	IQ_motif_EF-hand-BS	IQCF5 RASGRF2 ASPM MYO1B	8.63e-04	90	88	4	IPR000048
Domain	-	MTMR7 PTPRF MTMR1 PTPRU	9.37e-04	92	88	4	3.90.190.10
Domain	IQ	IQCF5 RASGRF2 ASPM MYO1B	9.76e-04	93	88	4	PS50096
Domain	WD40_repeat_CS	EML5 AMBRA1 EIPR1 LYST FBXW7	1.07e-03	164	88	5	IPR019775
Domain	EGF-like_dom	HGFAC HYAL3 LRP1 LRP4 LRP6 LRP5	1.15e-03	249	88	6	IPR000742
Domain	PNT	FLI1 ERG	1.17e-03	11	88	2	PS51433
Domain	Pointed_dom	FLI1 ERG	1.17e-03	11	88	2	IPR003118
Domain	SAM_PNT	FLI1 ERG	1.17e-03	11	88	2	PF02198
Domain	SAM_PNT	FLI1 ERG	1.17e-03	11	88	2	SM00251
Domain	Prot-tyrosine_phosphatase-like	MTMR7 PTPRF MTMR1 PTPRU	1.23e-03	99	88	4	IPR029021
Domain	Sulfotransfer_2	HS6ST2 HS6ST1	1.40e-03	12	88	2	PF03567
Domain	Sulfotransferase	HS6ST2 HS6ST1	1.40e-03	12	88	2	IPR005331
Domain	Quinoprot_gluc/sorb_DH	EML5 LRP1	1.40e-03	12	88	2	IPR011041
Domain	EGF-like_CS	HGFAC HYAL3 LRP1 LRP4 LRP6 LRP5	1.46e-03	261	88	6	IPR013032
Domain	EGF_2	HGFAC HYAL3 LRP1 LRP4 LRP6 LRP5	1.58e-03	265	88	6	PS01186
Domain	-	MRC1 HGFAC	1.66e-03	13	88	2	2.10.10.10
Domain	FN_type2_col-bd	MRC1 HGFAC	1.93e-03	14	88	2	IPR000562
Domain	FN2_2	MRC1 HGFAC	1.93e-03	14	88	2	PS51092
Domain	Myotubularin-like_Pase_dom	MTMR7 MTMR1	1.93e-03	14	88	2	IPR010569
Domain	PPASE_MYOTUBULARIN	MTMR7 MTMR1	1.93e-03	14	88	2	PS51339
Domain	Myotubularin_fam	MTMR7 MTMR1	1.93e-03	14	88	2	IPR030564
Domain	Myotub-related	MTMR7 MTMR1	1.93e-03	14	88	2	PF06602
Domain	fn2	MRC1 HGFAC	1.93e-03	14	88	2	PF00040
Domain	FN2_1	MRC1 HGFAC	1.93e-03	14	88	2	PS00023
Domain	FN2	MRC1 HGFAC	1.93e-03	14	88	2	SM00059
Domain	p53-like_TF_DNA-bd	FUT9 STAT1 STAT5B	2.00e-03	53	88	3	IPR008967
Domain	Nicotinic_acetylcholine_rcpt	CHRNA6 CHRNB4	2.52e-03	16	88	2	IPR002394
Domain	PH_dom-like	MTMR7 CMIP RASGRF2 MTMR1 MYO1B TEC LYST	3.97e-03	426	88	7	IPR011993
Domain	HEAT_REPEAT	ATR ULK4 HTT	4.41e-03	70	88	3	PS50077
Domain	IQ	IQCF5 ASPM MYO1B	4.59e-03	71	88	3	PF00612
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4	LRP4 LRP6 LRP5	3.44e-05	14	66	3	M47834
Pathway	REACTOME_SIGNALING_BY_SCF_KIT	PTPRU TEC STAT1 STAT5B	4.71e-05	43	66	4	M508
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	EPN3 MRC1 CROT LRP1 LRP4 LRP6 LRP5 ACAD10 CFI	6.64e-05	381	66	9	M48063
Pathway	WP_WNTBETACATENIN_SIGNALING_INHIBITORS_IN_CURRENT_AND_PAST_CLINICAL_TRIALS	LRP6 LRP5	2.14e-04	5	66	2	M48304
Pathway	WP_EPO_RECEPTOR_SIGNALING	PTPRU STAT1 STAT5B	2.36e-04	26	66	3	M39687
Pathway	WP_EPO_RECEPTOR_SIGNALING	PTPRU STAT1 STAT5B	2.36e-04	26	66	3	MM15896
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_AUTOPHAGY_VESICLE_NUCLEATION	AMBRA1 HTT	3.20e-04	6	66	2	M47681
Pathway	WP_KIT_RECEPTOR_SIGNALING_PATHWAY	PTPRU TEC STAT1 STAT5B	3.36e-04	71	66	4	MM15947
Pathway	KEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY	STAT1 STAT5B	4.47e-04	7	66	2	M47430
Pathway	PID_EPO_PATHWAY	TEC STAT1 STAT5B	4.84e-04	33	66	3	M233
Pathway	REACTOME_SIGNALING_BY_RNF43_MUTANTS	LRP6 LRP5	5.94e-04	8	66	2	M27433
Pathway	REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS	LRP6 LRP5	5.94e-04	8	66	2	MM14976
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA6 CHRNB4	7.61e-04	9	66	2	M27597
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA6 CHRNB4	7.61e-04	9	66	2	MM15313
Pathway	REACTOME_INTERLEUKIN_9_SIGNALING	STAT1 STAT5B	7.61e-04	9	66	2	M27861
Pathway	BIOCARTA_IL22BP_PATHWAY	STAT1 STAT5B	7.61e-04	9	66	2	MM1419
Pathway	BIOCARTA_IL22BP_PATHWAY	STAT1 STAT5B	7.61e-04	9	66	2	M8066
Pathway	REACTOME_INTERLEUKIN_21_SIGNALING	STAT1 STAT5B	9.48e-04	10	66	2	M27898
Pathway	PID_TCPTP_PATHWAY	ATR STAT1 STAT5B	9.88e-04	42	66	3	M91
Pathway	REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	CHRNA6 CHRNB4	1.16e-03	11	66	2	M883
Pubmed	Shh Plays an Inhibitory Role in Cusp Patterning by Regulation of Sostdc1.	LRP4 SOSTDC1 LRP6 LRP5	4.79e-11	4	93	4	30325689
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP1 LRP4 LRP6 LRP5	1.56e-08	11	93	4	24639464
Pubmed	Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.	LRP4 LRP6 LRP5	7.39e-08	4	93	3	21471202
Pubmed	Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.	SOSTDC1 LRP6 LRP5	7.39e-08	4	93	3	17002572
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP1 LRP4 LRP6 LRP5	2.77e-07	21	93	4	21337463
Pubmed	Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.	LRP4 LRP6 LRP5	3.68e-07	6	93	3	37091972
Pubmed	RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.	LRP4 LRP6 LRP5	6.43e-07	7	93	3	34847079
Pubmed	SOSTDC1-producing follicular helper T cells promote regulatory follicular T cell differentiation.	SOSTDC1 LRP6 LRP5	1.03e-06	8	93	3	32820125
Pubmed	Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.	LRP4 SOSTDC1 LRP6 LRP5	2.09e-06	34	93	4	23293290
Pubmed	ERG and FLI1 protein expression in epithelioid sarcoma.	FLI1 ERG	7.07e-06	2	93	2	24072183
Pubmed	Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.	LRP6 LRP5	7.07e-06	2	93	2	21887268
Pubmed	Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum.	CHRNA6 CHRNB4	7.07e-06	2	93	2	12150770
Pubmed	PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors.	LRP6 LRP5	7.07e-06	2	93	2	33136328
Pubmed	Synergistic Role of Endothelial ERG and FLI1 in Mediating Pulmonary Vascular Homeostasis.	FLI1 ERG	7.07e-06	2	93	2	28248553
Pubmed	LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.	LRP6 LRP5	7.07e-06	2	93	2	15084453
Pubmed	Elucidation of molecular impediments in the α6 subunit for in vitro expression of functional α6β4* nicotinic acetylcholine receptors.	CHRNA6 CHRNB4	7.07e-06	2	93	2	24085295
Pubmed	Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.	LRP6 LRP5	7.07e-06	2	93	2	33164872
Pubmed	LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.	LRP6 LRP5	7.07e-06	2	93	2	25902418
Pubmed	The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis.	FLI1 ERG	7.07e-06	2	93	2	10704859
Pubmed	Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.	FLI1 ERG	7.07e-06	2	93	2	30500808
Pubmed	Transdifferentiation of erythroblasts to megakaryocytes using FLI1 and ERG transcription factors.	FLI1 ERG	7.07e-06	2	93	2	26063314
Pubmed	Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections.	LRP1 ULK4	7.07e-06	2	93	2	27569546
Pubmed	The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.	LRP6 LRP5	7.07e-06	2	93	2	30474181
Pubmed	In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.	LRP6 LRP5	7.07e-06	2	93	2	36552732
Pubmed	Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes.	LRP6 LRP5	7.07e-06	2	93	2	25783012
Pubmed	Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.	FLI1 ERG	7.07e-06	2	93	2	33275876
Pubmed	Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.	LRP6 LRP5	7.07e-06	2	93	2	19147944
Pubmed	Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.	LRP6 LRP5	7.07e-06	2	93	2	15537447
Pubmed	LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.	LRP6 LRP5	7.07e-06	2	93	2	17335347
Pubmed	ERG and FLI1 are useful immunohistochemical markers in phosphaturic mesenchymal tumors.	FLI1 ERG	7.07e-06	2	93	2	26122367
Pubmed	The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.	LRP6 LRP5	7.07e-06	2	93	2	19503830
Pubmed	LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.	LRP6 LRP5	7.07e-06	2	93	2	37202775
Pubmed	Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.	LRP6 LRP5	7.07e-06	2	93	2	20926594
Pubmed	Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men.	LRP6 LRP5	7.07e-06	2	93	2	16355283
Pubmed	A polymorphism at the microRNA binding site in the 3' untranslated region of C14orf101 is associated with non-Hodgkin lymphoma overall survival.	TMEM260 RYR3	7.07e-06	2	93	2	24831772
Pubmed	Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.	LRP6 LRP5	7.07e-06	2	93	2	28425175
Pubmed	Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.	LRP6 LRP5	7.07e-06	2	93	2	18350154
Pubmed	Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk.	LRP1 LRP6	7.07e-06	2	93	2	26031789
Pubmed	Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).	LRP6 LRP5	7.07e-06	2	93	2	33118644
Pubmed	Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.	LRP6 LRP5	7.07e-06	2	93	2	18493104
Pubmed	Native α6β4* nicotinic receptors control exocytosis in human chromaffin cells of the adrenal gland.	CHRNA6 CHRNB4	7.07e-06	2	93	2	21917987
Pubmed	Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.	LRP6 LRP5	7.07e-06	2	93	2	30668923
Pubmed	Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.	LRP6 LRP5	7.07e-06	2	93	2	22433869
Pubmed	Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling.	HS6ST2 HS6ST1	7.07e-06	2	93	2	24563483
Pubmed	Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.	HS6ST2 HS6ST1	7.07e-06	2	93	2	12492399
Pubmed	Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.	LRP6 LRP5	7.07e-06	2	93	2	25802278
Pubmed	Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.	FLI1 ERG	7.07e-06	2	93	2	19666492
Pubmed	Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.	LRP6 LRP5	7.07e-06	2	93	2	33545636
Pubmed	HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.	HGFAC MLXIPL	7.07e-06	2	93	2	36413406
Pubmed	Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.	LRP6 LRP5	7.07e-06	2	93	2	12579474
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	RMDN3 MTMR7 TMEM186 GTF3C1 PTPRF LRP1 MRPS27 MTMR1 TMEM131L AMBRA1 PTPRU PRPF8	1.13e-05	974	93	12	28675297
Pubmed	Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning.	SOSTDC1 LRP6 LRP5	1.22e-05	17	93	3	20724449
Pubmed	Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.	FLI1 ERG STAT1	1.47e-05	18	93	3	20887958
Pubmed	Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis.	HYAL3 HAS3	2.12e-05	3	93	2	20849445
Pubmed	Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.	MRC1 ATR	2.12e-05	3	93	2	11715017
Pubmed	Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.	LRP6 LRP5	2.12e-05	3	93	2	24412065
Pubmed	Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.	LRP6 LRP5	2.12e-05	3	93	2	18524778
Pubmed	Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.	LRP6 LRP5	2.12e-05	3	93	2	25710911
Pubmed	A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors.	STAT1 STAT5B	2.12e-05	3	93	2	15010467
Pubmed	Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin.	LRP6 LRP5	2.12e-05	3	93	2	27803037
Pubmed	Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group.	FLI1 ERG	2.12e-05	3	93	2	20308669
Pubmed	Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial.	FLI1 ERG	2.12e-05	3	93	2	20308673
Pubmed	The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.	HS6ST2 HS6ST1	2.12e-05	3	93	2	10644753
Pubmed	Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.	LRP6 LRP5	2.12e-05	3	93	2	18406176
Pubmed	Lrp5 and Lrp6 play compensatory roles in mouse intestinal development.	LRP6 LRP5	2.12e-05	3	93	2	21866564
Pubmed	Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon.	LRP6 LRP5	2.12e-05	3	93	2	29602775
Pubmed	FLI1 and ERG protein degradation is regulated via Cathepsin B lysosomal pathway in human dermal microvascular endothelial cells.	FLI1 ERG	2.12e-05	3	93	2	32979864
Pubmed	LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children.	LRP6 LRP5	2.12e-05	3	93	2	18721193
Pubmed	tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells.	LRP6 LRP5	2.12e-05	3	93	2	23925701
Pubmed	ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells.	ASPM FBXW7	2.12e-05	3	93	2	38279565
Pubmed	The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.	LRP6 LRP5	2.12e-05	3	93	2	22589387
Pubmed	Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis.	HS6ST2 HS6ST1	2.12e-05	3	93	2	15499561
Pubmed	A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients.	FLI1 ERG	2.12e-05	3	93	2	20676125
Pubmed	The myotubularin family: from genetic disease to phosphoinositide metabolism.	MTMR7 MTMR1	2.12e-05	3	93	2	11275328
Pubmed	Wnt co-receptor LRP5/6 overexpression confers protection against hydrogen peroxide-induced neurotoxicity and reduces tau phosphorylation in SH-SY5Y cells.	LRP6 LRP5	2.12e-05	3	93	2	25959626
Pubmed	Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases.	HS6ST2 HS6ST1	2.12e-05	3	93	2	12611590
Pubmed	Next-generation sequencing to solve complex inherited retinal dystrophy: A case series of multiple genes contributing to disease in extended families.	PRPF8 USH2A	2.12e-05	3	93	2	28761320
Pubmed	Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.	LRP6 LRP5	2.12e-05	3	93	2	21397183
Pubmed	Wise regulates bone deposition through genetic interactions with Lrp5.	SOSTDC1 LRP5	2.12e-05	3	93	2	24789067
Pubmed	Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.	LRP6 LRP5	2.12e-05	3	93	2	22000856
Pubmed	Endoglin expression in the endothelium is regulated by Fli-1, Erg, and Elf-1 acting on the promoter and a -8-kb enhancer.	FLI1 ERG	2.12e-05	3	93	2	16484587
Pubmed	Molecular simulation analysis of the structure complex of C2 domains of DKK family members and β-propeller domains of LRP5/6: explaining why DKK3 does not bind to LRP5/6.	LRP6 LRP5	2.12e-05	3	93	2	24743782
Pubmed	Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway.	LRP6 LRP5	2.12e-05	3	93	2	33650028
Pubmed	Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory effects of heparin on the activities of various proteases in mast cells and the biosynthesis of 6-O-sulfated heparin.	HS6ST2 HS6ST1	2.12e-05	3	93	2	23223449
Pubmed	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.	LRP6 LRP5	2.12e-05	3	93	2	30664649
Pubmed	Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice.	STAT1 STAT5B	2.12e-05	3	93	2	10851049
Pubmed	Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation.	LRP6 LRP5	2.12e-05	3	93	2	22576936
Pubmed	Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease.	LRP6 LRP5	2.12e-05	3	93	2	25009587
Pubmed	A SMARCB1-deficient vulvar neoplasm with prominent myxoid stroma: report of a case showing ERG and FLI1 expression.	FLI1 ERG	2.12e-05	3	93	2	26261664
Pubmed	TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation.	LRP6 LRP5	2.12e-05	3	93	2	33065966
Pubmed	Overexpression of heparan sulfate 6-O-sulfotransferases in human embryonic kidney 293 cells results in increased N-acetylglucosaminyl 6-O-sulfation.	HS6ST2 HS6ST1	2.12e-05	3	93	2	16326709
Pubmed	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.	MPV17 GRHL1 HS6ST1 IMP4 THSD7B EIPR1 HTT ALPG	2.53e-05	442	93	8	15815621
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	EPN3 GDPD5 PTPRF LRP4 LRP5 AMBRA1 ULK4 HAS3 LARS2 LYST HTT IGSF3	3.89e-05	1105	93	12	35748872
Pubmed	Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.	RMDN3 CROT ETFDH NIPSNAP3A ACAD10 LARS2 KMO	3.91e-05	343	93	7	28130547
Pubmed	The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway.	LRP4 LRP6	4.23e-05	4	93	2	20093106
Pubmed	Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin.	LRP6 LRP5	4.23e-05	4	93	2	26772978
Pubmed	Differential effects of STAT proteins on growth hormone-mediated IGF-I gene expression.	STAT1 STAT5B	4.23e-05	4	93	2	25205818
Pubmed	Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.	LRP6 LRP5	4.23e-05	4	93	2	29176883
Pubmed	Stem domains of heparan sulfate 6-O-sulfotransferase are required for Golgi localization, oligomer formation and enzyme activity.	HS6ST2 HS6ST1	4.23e-05	4	93	2	15226404
Pubmed	The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.	FLI1 ERG	4.23e-05	4	93	2	18500345
Cytoband	2q21	HS6ST1 CDRT15P3	3.64e-04	14	93	2	2q21
Cytoband	Ensembl 112 genes in cytogenetic band chr4p11	CWH43 TEC	6.79e-04	19	93	2	chr4p11
Cytoband	4q31.3	TMEM131L FBXW7	1.82e-03	31	93	2	4q31.3
GeneFamily	Low density lipoprotein receptors	LRP1 LRP4 LRP6 LRP5	8.19e-08	13	61	4	634
GeneFamily	Sulfotransferases, membrane bound	HS6ST2 HS6ST1 GAL3ST4	2.62e-04	37	61	3	763
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTMR7 MTMR1	1.14e-03	15	61	2	903
GeneFamily	Cholinergic receptors nicotinic subunits	CHRNA6 CHRNB4	1.30e-03	16	61	2	173
GeneFamily	WD repeat domain containing	EML5 AMBRA1 EIPR1 LYST FBXW7	1.89e-03	262	61	5	362
GeneFamily	Protein tyrosine phosphatases, receptor type	PTPRF PTPRU	2.26e-03	21	61	2	813
GeneFamily	ETS transcription factor family	FLI1 ERG	4.00e-03	28	61	2	534
GeneFamily	SH2 domain containing	TEC STAT1 STAT5B	4.82e-03	101	61	3	741
GeneFamily	Phosphoinositide phosphatases	MTMR7 MTMR1	5.20e-03	32	61	2	1079
Coexpression	CHANG_IMMORTALIZED_BY_HPV31_DN	LRP1 PTPRU LYST CTSV STAT1	1.90e-06	60	89	5	M12051
Coexpression	GSE22282_HYPOXIA_VS_NORMOXIA_MYELOID_DC_DN	FLI1 CROT ATP8A1 LRP6 HRH4 RYR3 STAT5B	5.33e-06	199	89	7	M8065
Coexpression	DELYS_THYROID_CANCER_UP	MPV17 MRC1 PTPRF LRP4 PTPRU CFI STAT1 TIPARP IGSF3	2.07e-05	445	89	9	M3645
Coexpression	GSE2706_LPS_VS_R848_AND_LPS_2H_STIM_DC_DN	HGFAC TAS2R13 EML5 DNAH17 KMO CHRNB4	3.61e-05	181	89	6	M4724
Coexpression	GALE_APL_WITH_FLT3_MUTATED_UP	ATR MTMR1 MYO1B LARS2	4.90e-05	59	89	4	M3845
Coexpression	GSE6259_BCELL_VS_CD8_TCELL_UP	MTRF1 HS6ST1 TMEM131L LRP5 HAS3 TIPARP	5.16e-05	193	89	6	M6735
Coexpression	GSE3337_CTRL_VS_4H_IFNG_IN_CD8POS_DC_DN	RMDN3 FLI1 IMP4 MTMR1 STAT1 GSPT1	6.29e-05	200	89	6	M5099
Coexpression	GSE13522_CTRL_VS_T_CRUZI_Y_STRAIN_INF_SKIN_IFNAR_KO_UP	TMEM186 FFAR2 TEC LYST CTSV KMO	6.29e-05	200	89	6	M2929
CoexpressionAtlas	dev gonad_e12.5_F_DevVasOvary_Flk_top-relative-expression-ranked_100	KLHL6 MRC1 FLI1 ERG ASB4	3.41e-05	92	85	5	gudmap_dev gonad_e12.5_F_gudmap_devVasOvary_Flk_100
CoexpressionAtlas	dev gonad_e11.5_M_ReproVasc_Flk_top-relative-expression-ranked_100	KLHL6 MRC1 FLI1 ERG ASB4	3.60e-05	93	85	5	gudmap_dev gonad_e11.5_M_ReproVasc_Flk_100
CoexpressionAtlas	dev gonad_e11.5_F_ReproVasc_Flk_top-relative-expression-ranked_100	KLHL6 MRC1 FLI1 ERG ASB4	4.19e-05	96	85	5	gudmap_dev gonad_e11.5_F_ReproVasc_Flk_100
CoexpressionAtlas	dev gonad_e13.5_F_DevVascOvary_Flk_k-means-cluster#2_top-relative-expression-ranked_100	KLHL6 FLI1 ERG ASB4	5.59e-05	52	85	4	gudmap_dev gonad_e13.5_F_gudmap_devVascOvary_Flk_k2_100
CoexpressionAtlas	dev gonad_e13.5_F_DevVascOvary_Flk_k-means-cluster#2_top-relative-expression-ranked_200	KLHL6 MRC1 FLI1 ERG ASB4	8.03e-05	110	85	5	gudmap_dev gonad_e13.5_F_gudmap_devVascOvary_Flk_k2_200
CoexpressionAtlas	dev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#2_top-relative-expression-ranked_1000	KLHL6 MRC1 FLI1 ASB4	1.12e-04	62	85	4	gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k2_1000
CoexpressionAtlas	DevelopingKidney_e15.5_Podocyte cells_emap-27915_top-relative-expression-ranked_1000	KLHL6 MRC1 FLI1 MLXIPL GRHL1 ATP8A1 ERG THSD7A GAL3ST4 PTPRU HAS3 RYR3	1.20e-04	836	85	12	gudmap_developingKidney_e15.5_Podocyte cells_1000
CoexpressionAtlas	dev gonad_e13.5_M_DevVasTestis_Flk_k-means-cluster#2_top-relative-expression-ranked_200	KLHL6 MRC1 FLI1 ERG ASB4	1.36e-04	123	85	5	gudmap_dev gonad_e13.5_M_gudmap_devVasTestis_Flk_k2_200
CoexpressionAtlas	dev gonad_e13.5_M_DevVasTestis_Flk_k-means-cluster#4_top-relative-expression-ranked_500	KLHL6 MRC1 FLI1 ERG MYO1B ASB4 TEC	1.38e-04	282	85	7	gudmap_dev gonad_e13.5_M_gudmap_devVasTestis_Flk_k4_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000	ATP8A1 EML5 VPS13C GLP1R ETFDH ASPM FUT9 LRP4 MTMR1 SOSTDC1 PTPRU LARS2 FBXW7	1.39e-04	983	85	13	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
CoexpressionAtlas	dev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#3_top-relative-expression-ranked_500	KLHL6 FLI1 ASB4	1.89e-04	28	85	3	gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k3_500
CoexpressionAtlas	DevelopingKidney_e15.5_Podocyte cells_emap-27915_top-relative-expression-ranked_500	KLHL6 MRC1 FLI1 ERG THSD7A GAL3ST4 HAS3 RYR3	2.58e-04	415	85	8	gudmap_developingKidney_e15.5_Podocyte cells_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_2500_k-means-cluster#5	ATP8A1 EML5 THSD7A VPS13C ETFDH ASPM FUT9 LRP4 PTPRU FBXW7	2.81e-04	654	85	10	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_2500_K5
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GDPD5 CHRNA6 GLT6D1 MTMR7 DNAH17 LRP4	9.03e-07	155	93	6	51f6447945389649d99dcf7603b396195c631ead
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	GDPD5 CHRNA6 GLT6D1 MTMR7 DNAH17 LRP4	9.03e-07	155	93	6	23dc71cab28094ca0ac4d2baf4e24871ed107781
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	EML5 PTPRF LRP6 MYO1B CFI IGSF3	1.17e-06	162	93	6	2259e9536147e9cdee772e3a30ba7d104573262c
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	EML5 PTPRF LRP6 MYO1B CFI IGSF3	1.35e-06	166	93	6	89e2b8453180983533faccb4275867861876d7ee
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CROT P2RX6 ETFDH MYO1B LARS2 KMO	1.66e-06	172	93	6	feaaf8ca7983d04a59ed0a7b3fb0e6d4b3a055f2
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CROT P2RX6 ETFDH MYO1B LARS2 KMO	1.66e-06	172	93	6	9adfb4a65669cc536343616637058d0a4728013f
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CROT P2RX6 ETFDH MYO1B LARS2 KMO	1.66e-06	172	93	6	8aed9c113f27d00401c272a3684495a4bc75bd0f
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	FLI1 CMIP ATP8A1 ERG THSD7A RASGRF2	2.69e-06	187	93	6	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	FLI1 CMIP ERG THSD7A RASGRF2 LYST	2.94e-06	190	93	6	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CWH43 THSD7A PTPRF HS6ST1 MYO1B STAT1	3.13e-06	192	93	6	d5ec4cdb15620a5abfc83577353501186c2bc86a
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CWH43 THSD7A PTPRF HS6ST1 MYO1B STAT1	3.22e-06	193	93	6	5da60321bcf761913eb30779b6d8b1e933c5e51e
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-LBH\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC CHRNA6 THSD7A GLP1R KMO RYR3	3.96e-06	200	93	6	0ff2607c58bc929e203f407ecf3605e0b21bfa90
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-LBH-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HGFAC CHRNA6 THSD7A GLP1R KMO RYR3	3.96e-06	200	93	6	de23a5d22d94935802b5b84a9e029b3f62c57028
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_SOX11\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 GLP1R FBXL21P KMO	2.16e-05	160	93	5	4cc34f40b56da39fbd26592fbdb4c07e7318d306
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLI1 GDPD5 ATP8A1 ERG CFI	2.16e-05	160	93	5	33050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCell	droplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ERG ATR RASGRF2 TMEM131L FBXL21P	2.50e-05	165	93	5	c39f0479955c4e23921f7a450d3bc251a002200f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-2_VIP_RPL41P3\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A GLP1R KMO	2.88e-05	170	93	5	31e3f57673c99f4d8ef30faa9c40e5f7f5bf6460
ToppCell	severe-Myeloid-Eosinophils\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	GDPD5 THSD7A P2RX6 HRH4 TEC	2.88e-05	170	93	5	863f0266d5837cdbc3e09a3fe6a99dd3e6261674
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A KMO RYR3	2.88e-05	170	93	5	36dbbdb13f69307afd2122ff051b2980850c1f00
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 GRHL1 MTMR7 FFAR2 ASPM	2.97e-05	171	93	5	845f312f8cbe29d820da25f0e6d75deb382bbfd8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-2_VIP_RPL41P3\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A TMEM131L KMO	2.97e-05	171	93	5	f6047dee2be0b09ad4d48f97369111bc92e89b35
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-5_VIP_KCNJ2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC THSD7A THSD7B KMO IGSF3	3.22e-05	174	93	5	fdadac1eaab2c4a67e4832f0901df22e893add6a
ToppCell	10x5'-blood-Mast-Mast_cells\|blood / Manually curated celltypes from each tissue	GDPD5 ERG THSD7A HRH4 RYR3	3.22e-05	174	93	5	a5838821bba2be790d32331ff529d466e9974268
ToppCell	10x5'-blood-Mast\|blood / Manually curated celltypes from each tissue	GDPD5 ERG THSD7A HRH4 RYR3	3.22e-05	174	93	5	3a8a253213b207e3ff56f94a74996b8d9ad47aa1
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Non-keratinizing_Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	CROT CMIP LRP1 HAS3 IGSF3	3.31e-05	175	93	5	0cc215109d9915af47e4d0a120ce2e46910715fa
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHRNA6 THSD7A MYO1B THSD7B KMO	3.69e-05	179	93	5	c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	3.69e-05	179	93	5	97ba67a856680f24846244c0b92c886cc0e79537
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KLHL6 FLI1 PTX4 TEC LYST	3.79e-05	180	93	5	ca2a35bfb67347e47f511589a3d0f763e6664634
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KLHL6 FLI1 PTX4 TEC LYST	3.79e-05	180	93	5	4e9e8cde2919610c4ac0025b1c9819808048bc1d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CHRNA6 THSD7A THSD7B KMO RYR3	3.79e-05	180	93	5	b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KLHL6 FLI1 PTX4 TEC LYST	3.79e-05	180	93	5	466381bf93c3da6a2a241daadb68e9aad2964eae
ToppCell	severe-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	GDPD5 THSD7A P2RX6 HRH4 TEC	3.79e-05	180	93	5	ac03812b1409435c55d323a7516deeac82bd3509
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	3.99e-05	182	93	5	7dc61e901428cea04f00ebb0939a44d21a6145c6
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	3.99e-05	182	93	5	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CWH43 HS6ST1 ULK4 MYO1B MARCHF11	3.99e-05	182	93	5	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KLHL6 MRC1 RMDN3 LRP1 CHRNB4	4.10e-05	183	93	5	103c4c4595d8daa677679fd2fa1e99cd398e56dd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CROT THSD7A HS6ST1 MYO1B ASB4	4.10e-05	183	93	5	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	4.10e-05	183	93	5	e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	4.32e-05	185	93	5	16e9ccea0e3b95d90dc48ef74206c805681dac0b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	4.32e-05	185	93	5	027020754dbf71b0034791f9a34ae795e3b85f81
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GRHL1 ATP8A1 THSD7A HS6ST2 LRP6	4.32e-05	185	93	5	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	4.32e-05	185	93	5	487fa382232564f075960899d50afa0edae5d258
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	4.32e-05	185	93	5	08fad1e3c3cc5f1c3eb6629a49c094b628e75a92
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	4.32e-05	185	93	5	cefd81adb480c027545a5c78dcd05669783717f4
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	4.32e-05	185	93	5	bdfa8c284bbc5e85c806327fbb7778cf16242a38
ToppCell	droplet-Fat-Scat-21m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPN3 GRHL1 CWH43 PTPRF FUT9	4.43e-05	186	93	5	59710cff3f6f7c318ee2524b44c1a909f312c25e
ToppCell	droplet-Fat-Scat-21m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPN3 GRHL1 CWH43 PTPRF FUT9	4.43e-05	186	93	5	de88fafac51049ec1920695844d8ce8057940272
ToppCell	droplet-Fat-Scat-21m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPN3 GRHL1 CWH43 PTPRF FUT9	4.43e-05	186	93	5	7ff73ab8fed5da779ee9c7bd2e14a8363edb7509
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	4.54e-05	187	93	5	ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	MLXIPL CMIP RASGRF2 THSD7B LYST	4.54e-05	187	93	5	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	wk_15-18-Hematologic_Lymphocytic-B-small_pre-B-II_cell\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	KLHL6 FLI1 ATP8A1 TMEM131L KMO	4.66e-05	188	93	5	56d78b5a86a71b2e752db379f4a46dc4c623b553
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	FLI1 CMIP ERG THSD7A RASGRF2	4.78e-05	189	93	5	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ATP8A1 PTPRF MYO1B HAS3 CFI	4.78e-05	189	93	5	2d32f09efa982ae458568f6b1cd06bb5078d42a3
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ATP8A1 PTPRF HS6ST2 FUT9 HAS3	4.90e-05	190	93	5	625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	FLI1 ERG THSD7A RASGRF2 MYO1B	4.90e-05	190	93	5	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp4_Mab21l1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	THSD7A SOSTDC1 THSD7B IGSF3	4.91e-05	96	93	4	78f19fee755061b4144b1beebb60f4e8bc4dbf0d
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	5.02e-05	191	93	5	764c3a8829ae1253a0790744138266e81fc075ec
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|lung / Disease (COVID-19 only), tissue and cell type	KLHL6 MRC1 RMDN3 LRP1 KMO	5.02e-05	191	93	5	dab953682b8c9ed680a799161f837f792a7e4f33
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	FLI1 CMIP ERG THSD7A PTPRF	5.15e-05	192	93	5	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	COVID-19-lung-Macrophage_PPARGhi_CD5Lhi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KLHL6 MRC1 RMDN3 LRP1 KMO	5.15e-05	192	93	5	bcfb9c005166bc0b4f8ee2dfc0c1540e8bf0e1ff
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 THSD7A THSD7B KMO	5.15e-05	192	93	5	3abee376c37c3646da33ac381aa63d50a01607a6
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD7A PTPRF HS6ST1 MYO1B STAT1	5.15e-05	192	93	5	9e031bf93eb8757fdd0cc22f01b44e48f85532d5
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	THSD7A PTPRF HS6ST1 MYO1B STAT1	5.15e-05	192	93	5	3d777d07878269b87ec7e1f06489cae7c989d633
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MTMR7 EML5 PTPRF FUT9 HAS3	5.15e-05	192	93	5	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	RV-10._Endothelium_II\|RV / Chamber and Cluster_Paper	FLI1 CMIP ERG THSD7A RASGRF2	5.28e-05	193	93	5	01c2df9206f1527c578e808978e58196c35e72f5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FLI1 ERG THSD7A RASGRF2 RYR3	5.28e-05	193	93	5	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	5'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HGFAC ERG THSD7A LYST RYR3	5.28e-05	193	93	5	c0973a2c97deb7176c2f617c8760a55f7edc9839
ToppCell	RV-10._Endothelium_II\|World / Chamber and Cluster_Paper	FLI1 CMIP ERG THSD7A RASGRF2	5.28e-05	193	93	5	2531266bc57339d4e2b22a88817008e32b8c1598
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial1_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	FLI1 GDPD5 ERG FUT9 THSD7B	5.41e-05	194	93	5	32ba2cf9b8726bc3c6e9dc24b54d22ff188bb12b
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLI1 GDPD5 ATP8A1 ERG CFI	5.41e-05	194	93	5	23f2a627226aaed468c55adc42ab22e051dfe7fe
ToppCell	Immune-alveolar_macrophage_(MARCO_positive)\|World / Lineage, Cell type, age group and donor	KLHL6 MRC1 RMDN3 LRP1 KMO	5.54e-05	195	93	5	f92114ef995e690a3bedc62c89c5fd6773d0d9f7
ToppCell	facs-Aorta-Heart-3m-Endothelial-aorta_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLHL6 MRC1 CMIP ERG PTPRU	5.54e-05	195	93	5	3969b8d5fcec8ef1831531a781f7bbcebab5a4ba
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	MRC1 FLI1 ERG THSD7A THSD7B	5.68e-05	196	93	5	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	AT2_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	PTPRF HS6ST2 MYO1B HAS3 CFI	5.82e-05	197	93	5	5e0d222872a25bb9e9069d3dffda2844bb69874a
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KLHL6 MRC1 RMDN3 LRP1 KMO	5.96e-05	198	93	5	e125eb8aa57c172e5518874da1bd25998292f5e2
ToppCell	Sigmoid-B_cell-B_cell_IgG_Plasma\|B_cell / Region, Cell class and subclass	CWH43 HRH4 RYR3 TIPARP FBXW7	5.96e-05	198	93	5	305d7ae9b070ac7211638a5282374c02bf13af40
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KLHL6 MRC1 RMDN3 LRP1 KMO	5.96e-05	198	93	5	0baeb8e2c199ff10bb5c829c523546af3c9227c1
ToppCell	Parenchymal-NucSeq-Immune_Myeloid\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KLHL6 MRC1 FLI1 LRP1 KMO	6.10e-05	199	93	5	7ee2805fd9143eba11bf6832267b62189683608b
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-BAGE2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CHRNA6 THSD7A THSD7B KMO RYR3	6.25e-05	200	93	5	26f07d271e984f375145e4c10528fba44a5811e1
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	ATP8A1 EML5 PTPRF VPS13C PTPRU	6.25e-05	200	93	5	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	Neuronal-Inhibitory-iA-iA_1(SST_PAX6)-SST-BAGE2-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CHRNA6 THSD7A THSD7B KMO RYR3	6.25e-05	200	93	5	c3637827ceba16b0d7956c280dd2ddbc8b1ba55e
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	THSD7A GLP1R THSD7B IGSF3	1.33e-04	124	93	4	36dfc702a570e1a1a6dde09f38badf9023ea7287
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Car10\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	HGFAC THSD7A THSD7B IGSF3	1.41e-04	126	93	4	61e599678680e5aa86291c2b347b2995014591ea
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Ptgfr\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ERG HAS3 MARCHF11 RYR3	1.46e-04	127	93	4	fb58f4b4d3722f4b9a2e4946c0244c5b70dd883b
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Undifferentiated_Pleomorphic_Sarcoma-4\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	GRHL1 HS6ST2 DNAH17 C3orf20	1.64e-04	131	93	4	2ccf679b5035b7b9cdb9a9a660cad90288592187
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CHRNA6 GLT6D1 ASPM CTSV	1.79e-04	134	93	4	e0f3ca643c206929203d80095663a5eac98ac088
ToppCell	COVID-19-kidney-Technical/muscle_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	ERG THSD7B USH2A CDH12	2.06e-04	139	93	4	64c35411bbe67acb5010dadc4b0b1be0f8b17737
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Igfbp6_Pltp\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	THSD7A GLP1R THSD7B IGSF3	2.06e-04	139	93	4	9e9f29f92dbe65b26cc78b3a1c00778c6a701f5b
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CHRNA6 ERG MARCHF11 RYR3	2.12e-04	140	93	4	7cc891d676555609add6fc7880735d948a2ad801
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CWH43 THSD7A HS6ST1 EIPR1	2.12e-04	140	93	4	e64f6aa57bc069cfe970089bd1c298433bfaf771
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_low-phase\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HS6ST2 ASPM THSD7B PTPRU	2.36e-04	144	93	4	f6061dd965a2b2fe6ad864f8aecc06d2e74881ce
ToppCell	droplet-Liver-hepatocytes-3m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CROT PTPRF MYO1B CFI	2.55e-04	147	93	4	00619115b9a1ec2b967c2992043b41974ece63c4
ToppCell	356C-Myeloid-Mast_cell\|356C / Donor, Lineage, Cell class and subclass (all cells)	ERG HS6ST1 LRP4 HRH4	2.62e-04	148	93	4	1668d8a9e680da335362744f36b05446c499347e
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FUT9 THSD7B USH2A CDH12	2.62e-04	148	93	4	d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCell	356C-Myeloid-Mast_cell-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ERG HS6ST1 LRP4 HRH4	2.62e-04	148	93	4	18511ba10765eda937c5a710626361f7e6b9b321
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	THSD7A SOSTDC1 RYR3 IGSF3	2.68e-04	149	93	4	10ffd0051fb027bbebc662ca602c80d89bbf99c6
ToppCell	Control-PLT_4\|World / Disease Group and Platelet Clusters	ERG ATR TEC TIPARP	3.04e-04	154	93	4	a2a03c5e6759c45aeeedf1e68ecb5a0112ef9a20
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 LINC02902 FBXL21P	3.12e-04	155	93	4	523a821963d2aecb67da7133a9a4b3bc33309b58
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MRC1 MTMR7 FFAR2 LRP1	3.35e-04	158	93	4	6811dc4f101dfa9a9cc13d949760d43aa522bf3b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_VIP_SOX11\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HGFAC CHRNA6 GLP1R FBXL21P	3.43e-04	159	93	4	255094ca07b09c68c00f45f2490fe775b25efbba
Drug	AC1L1KOK	LRP1 HRH4 TEC LARS2	2.96e-06	25	92	4	CID000005588
Disease	total lipids in very large HDL measurement	HGFAC MLXIPL CMIP ETFDH	5.27e-05	66	91	4	EFO_0022312
Disease	Extra-osseous Ewing's sarcoma	FLI1 ERG	5.62e-05	4	91	2	C0279980
Disease	tyrosine-protein kinase TEC measurement	TEC TEC	5.62e-05	4	91	2	EFO_0020830
Disease	cholesterol in very large HDL measurement	HGFAC MLXIPL CMIP ETFDH	6.28e-05	69	91	4	EFO_0022229
Disease	hepatocyte growth factor activator measurement	HGFAC HTT	1.96e-04	7	91	2	EFO_0008152
Disease	Ewings sarcoma	FLI1 ERG	2.60e-04	8	91	2	C0553580
Disease	R-6-hydroxywarfarin to R-warfarin ratio measurement	FLI1 DNAH17 ULK4 CDH12	3.31e-04	106	91	4	EFO_0803333
Disease	centronuclear myopathy X-linked (implicated_via_orthology)	MTMR7 MTMR1	3.34e-04	9	91	2	DOID:0111225 (implicated_via_orthology)
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	STAT1 STAT5B FBXW7	5.95e-04	53	91	3	C1961099
Disease	cholesterol to total lipids in large HDL percentage	MLXIPL CMIP ETFDH	6.63e-04	55	91	3	EFO_0022234
Disease	triglycerides in large VLDL measurement	HGFAC MLXIPL CMIP	6.99e-04	56	91	3	EFO_0022178
Disease	triglycerides in very large VLDL measurement	HGFAC MLXIPL CMIP	6.99e-04	56	91	3	EFO_0022325
Disease	triglycerides in VLDL measurement	HGFAC MLXIPL CMIP	8.14e-04	59	91	3	EFO_0022326
Disease	cholesteryl esters to total lipids in large HDL percentage	MLXIPL CMIP ETFDH	8.14e-04	59	91	3	EFO_0022248
Disease	triglycerides to total lipids in large HDL percentage	MLXIPL CMIP ETFDH	8.55e-04	60	91	3	EFO_0022330
Disease	free cholesterol to total lipids in medium HDL percentage	MLXIPL CMIP ETFDH	8.55e-04	60	91	3	EFO_0022282
Disease	triglycerides in small VLDL measurement	HGFAC MLXIPL CMIP	8.97e-04	61	91	3	EFO_0022145
Disease	triglycerides in small HDL measurement	HGFAC MLXIPL CMIP	9.41e-04	62	91	3	EFO_0022158
Disease	phospholipids in large VLDL measurement	HGFAC MLXIPL CMIP	9.41e-04	62	91	3	EFO_0022169
Disease	triglycerides to total lipids in very large HDL percentage	HGFAC MLXIPL CMIP	9.41e-04	62	91	3	EFO_0022339
Disease	total lipids in very large VLDL measurement	HGFAC MLXIPL CMIP	9.41e-04	62	91	3	EFO_0022313
Disease	phospholipids in very large VLDL measurement	HGFAC MLXIPL CMIP	9.41e-04	62	91	3	EFO_0022299
Disease	phosphoenolpyruvic acid measurement	CMIP CDH12	9.62e-04	15	91	2	EFO_0010522
Disease	glycerate measurement	THSD7B RYR3	9.62e-04	15	91	2	EFO_0021029
Disease	free cholesterol to total lipids in medium LDL percentage	HGFAC MLXIPL CMIP	9.86e-04	63	91	3	EFO_0022283
Disease	phospholipids in chylomicrons and extremely large VLDL measurement	HGFAC MLXIPL CMIP	9.86e-04	63	91	3	EFO_0022292
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	HGFAC MLXIPL CMIP ETFDH	1.05e-03	144	91	4	EFO_0004611, EFO_0020943
Disease	diastolic blood pressure, systolic blood pressure	MRC1 HGFAC LIG3 CMIP ERG LRP1 ULK4 FBXW7	1.10e-03	670	91	8	EFO_0006335, EFO_0006336
Disease	phospholipids in very large HDL measurement	HGFAC MLXIPL ETFDH	1.13e-03	66	91	3	EFO_0022298
Disease	total lipids in large VLDL	HGFAC MLXIPL CMIP	1.18e-03	67	91	3	EFO_0022175
Disease	Abdominal Aortic Aneurysm	ERG LRP1 CHRNB4	1.23e-03	68	91	3	EFO_0004214
Disease	triglycerides to phosphoglycerides ratio	HGFAC MLXIPL CMIP	1.23e-03	68	91	3	EFO_0022327
Disease	free cholesterol in large VLDL measurement	HGFAC MLXIPL CMIP	1.23e-03	68	91	3	EFO_0022265
Disease	triglycerides to total lipids in very small VLDL percentage	HGFAC MLXIPL CMIP	1.28e-03	69	91	3	EFO_0022341
Disease	very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio	HGFAC MLXIPL CMIP LRP4 HTT	1.37e-03	264	91	5	EFO_0008317, EFO_0020944
Disease	cholesteryl esters to total lipids in very small VLDL percentage	HGFAC MLXIPL CMIP	1.39e-03	71	91	3	EFO_0022259
Disease	Malignant neoplasm of endometrium	ATR FBXW7	1.39e-03	18	91	2	C0007103
Disease	Carcinoma in situ of endometrium	ATR FBXW7	1.39e-03	18	91	2	C0346191
Disease	Alcoholic Intoxication, Chronic	RASGRF2 THSD7B CDH12 CHRNB4 TIPARP	1.47e-03	268	91	5	C0001973
Disease	cystathionine measurement	TEC TEC	1.55e-03	19	91	2	EFO_0010474
Disease	total lipids in large HDL	MLXIPL CMIP ETFDH	1.57e-03	74	91	3	EFO_0022189
Disease	free cholesterol to total lipids in large LDL percentage	HGFAC MLXIPL CMIP	1.57e-03	74	91	3	EFO_0022280
Disease	polymyositis	THSD7A LRP5	1.72e-03	20	91	2	EFO_0003063
Disease	free cholesterol in large HDL measurement	MLXIPL CMIP ETFDH	1.89e-03	79	91	3	EFO_0022157
Disease	high density lipoprotein particle size measurement	HGFAC MLXIPL CMIP ETFDH	1.93e-03	170	91	4	EFO_0008592
Disease	cholesterol in large HDL measurement	MLXIPL CMIP ETFDH	1.96e-03	80	91	3	EFO_0021900
Disease	insular cortex volume measurement	THSD7A VPS13C	2.28e-03	23	91	2	EFO_0010309
Disease	cigarettes per day measurement	CHRNA6 MLXIPL THSD7A AMBRA1 THSD7B CHRNB4	2.38e-03	438	91	6	EFO_0006525
Disease	Charcot-Marie-Tooth disease (implicated_via_orthology)	MTMR7 MTMR1	2.48e-03	24	91	2	DOID:10595 (implicated_via_orthology)
Disease	breast cancer (implicated_via_orthology)	ATR STAT1	2.69e-03	25	91	2	DOID:1612 (implicated_via_orthology)
Disease	colon adenocarcinoma (is_implicated_in)	STAT1 STAT5B	2.91e-03	26	91	2	DOID:234 (is_implicated_in)
Disease	total cholesterol measurement, high density lipoprotein cholesterol measurement	RMDN3 HGFAC MLXIPL CMIP ETFDH	2.95e-03	315	91	5	EFO_0004574, EFO_0004612

Protein segments in the cluster

Peptide	Gene	Start	Entry
LKQEWTDYRLTWNSS	CHRNB4	81	P30926
KTHRYQIWTTVVDWI	CFI	386	P05156
DTKWYQWKATHRRLY	CTSV	26	O60911
VVNAYEHIRWNTKWR	ASB4	341	Q9Y574
KWRKLHRDQEYEVTW	APOBEC3G	76	Q9HC16
WRRLNDSGKNWRHVY	EPN3	61	Q9H201
TDHVRQWLEWAVKEY	ERG	136	P11308
HCSQSWAQWKLWRQR	CDRT15P3	111	P0DPF6
SYLRDQWFHSLQWKK	CMIP	146	Q8IY22
RLQWVWRTAFLKHTQ	ACAD10	11	Q6JQN1
VASNIANTTYRLQWW	AMBRA1	851	Q9C0C7
KRYLWATVTIQRHWR	ASPM	1391	Q8IZT6
SAIWNRRHSGKDWYL	ATP8A1	316	Q9Y2Q0
LSHLELWVNYYVRWN	MTMR1	591	Q13613
TEYGALNRVHVLWWN	NIPSNAP3A	186	Q9UFN0
VEWRWHPYTNTARKR	IMP4	271	Q96G21
YHWQIKRTTTQKWQS	TIPARP	266	Q7Z3E1
WQVRHCWHQVTRTRF	C22orf46	51	C9J442
YHQRKSPWWRSIAVV	FFAR2	246	O15552
WIQIEYLNIGRWRHK	KLHL6	401	Q8WZ60
KIQERTYSLWAHLWK	MTMR7	451	Q9Y216
TYSLWAHLWKNRADY	MTMR7	456	Q9Y216
SLWETVQKWREYRRQ	GLP1R	31	P43220
VYWTDWRTNTLAKAN	LRP1	1491	Q07954
WVVSNWNPEHARVKY	FUT9	191	Q9Y231
YWTDWQTRSIHACNK	LRP5	251	O75197
WNSWYHLRTLRRQAN	LINC00312	46	Q9Y6C7
YWTDWQRRSIERVHK	LRP6	546	O75581
YWTDWSRRSIERANK	LRP6	846	O75581
RWKRYQRSHDDTTPW	GDPD5	26	Q8WTR4
KHHWRDVRQFSQWSE	LIG3	26	P49916
DWALYVHFNRSLWAR	GAL3ST4	366	Q96RP7
KWCATTHNYDRDRAW	HGFAC	131	Q04756
LNAVRIIQVYWRWHS	IQCF5	91	A8MTL0
IIQVYWRWHSCHSRV	IQCF5	96	A8MTL0
KTLEEHSHWVWNVRY	EIPR1	266	Q53HC9
KNRETWYLSWALDTN	GSPT1	116	P15170
YLSEWRHVQRGATWK	HS6ST1	191	O60243
TQWFLQKHISQDREW	PKD1L2	71	Q7Z442
WAEVHAVSLQTYKLW	PTPRU	331	Q92729
WLAKHQGARYVWNRT	ALPG	256	P10696
NSWVWKELYSVRNIR	ETFDH	441	Q16134
ETNLWLRHIWNDYKL	CHRNA6	81	Q15825
WRTAVYNWALQSSHE	ATR	651	Q13535
LLVNHTDYRWWAEVQ	HTT	1841	P42858
VAELWRKNYNNTWTR	IGSF3	646	O75054
WKYWHSRQHTAKQRC	GRHL1	321	Q9NZI5
IRYHEAVQRWHWQKK	KMO	406	O15229
FTWQAQLRHRWDEEK	DNAH17	1781	Q9UFH2
VAQLHAWWYFRNTKN	GLT6D1	191	Q7Z4J2
QGYVVHKWSWTSRTE	C3orf20	456	Q8ND61
WKSAYIRQHRIDTNW	FBXW7	351	Q969H0
EHVRQWLEWAIKEYS	FLI1	136	Q01543
RRRAYQAASWAWAQQ	HYAL3	141	O43820
SHWLSWARCKVLYIN	LINC02902	106	Q6ZTY9
HKRWWQLRDNAVEIF	LYST	3076	Q99698
YRVFKRWRAVNLHWD	MARCHF11	306	A6NNE9
YLSEWRHVQRGATWK	HS6ST2	331	Q96MM7
RSHFQRVKRGWVWNQ	CDH12	46	P55289
LNQQTRWSKSYFREW	HAS3	351	O00219
VTNVRWSHDYQWVIS	EML5	566	Q05BV3
STRRAYWKEWAKRNH	FAM166A	301	Q6J272
SITLWHNLNYWQLLR	CROT	126	Q9UKG9
EKSYNFRTATHWWEQ	P2RX6	291	O15547
IWTSTQGRYWLHVDR	PTX4	366	Q96A99
KWTEYRVWVRAHTDV	PTPRF	676	P10586
LTDNQYTWTDKWRVR	MRC1	1161	P22897
RWNEVFHISDLWRKF	FBXL21P	71	Q9UKT6
VQAVTWWSGSHLQRY	CWH43	106	Q9H720
NIYWSLWKRDHLSRC	HRH4	196	Q9H3N8
NWTIHTWIRQCLKYD	MRPS27	106	Q92552
HIKDWLDRYERNTTW	TAS2R13	151	Q9NYV9
EDLNRWHNIYSGTQW	USH2A	2871	O75445
RWCYQVSHLSWLEKK	RMDN3	371	Q96TC7
RQYLAQWLEKQDWEH	STAT1	31	P42224
QSYRWKTHKWRRCQL	THSD7A	831	Q9UPZ6
GLWSIWYRNHFDRSV	TMEM131L	406	A2VDJ0
YTLQTRKDVEKWWHQ	LARS2	51	Q15031
YLILEKNDVHWWRAR	TEC	206	P42680
KNDVHWWRARDKYGN	TEC	211	P42680
VETLWKTFWRYNLSQ	RFX1	631	P22670
ASRWHEKWFALYQNV	RASGRF2	36	O14827
RHYLSQWIESQAWDS	STAT5B	31	P51692
VAVIWNSYLSWKAHR	MPV17	161	P39210
DYVRTRTLHNWKFWV	MLXIPL	756	Q9NP71
NWSRRYCHQDTKMLW	MTRF1	56	O75570
TTKWEWLVNQHRDSY	SF3B5	26	Q9BWJ5
RYVKAKADWWTNTAH	PRPF8	741	Q6P2Q9
KADWWTNTAHYNRER	PRPF8	746	Q6P2Q9
HNVWAKDRIKQGWTY	RYR3	991	Q15413
RVAHLNFWGWRQDTY	TMEM186	141	Q96B77
LHTNGRRWWKYAIDS	VPS13C	366	Q709C8
RRWWKYAIDSVLEVH	VPS13C	371	Q709C8
KYWSRRSSQEWRCVN	SOSTDC1	121	Q6X4U4
YHYTWKASLWNNNER	THSD7B	1431	Q9C0I4
HLKRNWIWTSYIINQ	GTF3C1	1126	Q12789
YLNHARWTWGDQTTL	TMEM260	241	Q9NX78
QKRLTWTRLLQHSFW	ULK4	266	Q96C45
YWTDWQTRSIHRADK	LRP4	1266	O75096
ARNKHAIAVIWAYWL	MYO1B	806	O43795