Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionMHC class II protein complex binding

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.62e-0527433GO:0023026
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC25A38 SLC9B1 CACNA1I SLC9A2 SLC11A2 GJE1 CLCN2 SLC7A7 SLC18A3 SLC22A3 SLC25A13

2.92e-0511804311GO:0022857
GeneOntologyMolecularFunctionorganic cation transmembrane transporter activity

SLC25A38 SLC7A7 SLC18A3 SLC22A3

3.03e-0583434GO:0015101
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC9B1 SLC9A2 SLC11A2 SLC18A3 SLC22A3 SLC25A13

3.88e-05296436GO:0015291
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC9B1 SLC9A2 SLC11A2 SLC18A3 SLC22A3 SLC25A13

4.26e-05301436GO:0022853
GeneOntologyMolecularFunctionproton transmembrane transporter activity

SLC9B1 SLC9A2 SLC11A2 SLC18A3 SLC25A13

5.05e-05188435GO:0015078
GeneOntologyMolecularFunctiontransporter activity

SLC25A38 SLC9B1 CACNA1I SLC9A2 SLC11A2 GJE1 CLCN2 SLC7A7 SLC18A3 SLC22A3 SLC25A13

6.56e-0512894311GO:0005215
GeneOntologyMolecularFunctionMHC protein complex binding

HLA-DRB1 HLA-DRB3 HLA-DRB4

9.37e-0541433GO:0023023
GeneOntologyMolecularFunctionpeptide antigen binding

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.60e-0449433GO:0042605
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC9B1 CACNA1I SLC9A2 SLC11A2 CLCN2 SLC18A3 SLC22A3 SLC25A13

1.85e-04758438GO:0015318
GeneOntologyMolecularFunctionretromer complex binding

SORT1 SLC11A2

2.02e-0410432GO:1905394
GeneOntologyMolecularFunctionantiporter activity

SLC9B1 SLC9A2 SLC18A3 SLC25A13

2.19e-04138434GO:0015297
GeneOntologyMolecularFunctionMHC class II receptor activity

HLA-DRB1 HLA-DRB3

2.46e-0411432GO:0032395
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC9B1 CACNA1I SLC9A2 SLC11A2 CLCN2 SLC18A3 SLC22A3 SLC25A13

2.52e-04793438GO:0015075
GeneOntologyMolecularFunctionmonoamine transmembrane transporter activity

SLC18A3 SLC22A3

2.95e-0412432GO:0008504
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

SLC9B1 CACNA1I SLC9A2 SLC11A2 SLC18A3 SLC22A3 SLC25A13

3.51e-04627437GO:0022890
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SLC25A38 SLC7A7 SLC25A13

4.80e-0471433GO:0015179
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC9B1 CACNA1I SLC9A2 SLC22A3

4.94e-04171434GO:0015081
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC9B1 CACNA1I SLC9A2 SLC11A2 SLC18A3 SLC22A3 SLC25A13

4.95e-04664437GO:0008324
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC9B1 SLC9A2 SLC11A2 SLC18A3 SLC22A3 SLC25A13

5.19e-04477436GO:0022804
GeneOntologyMolecularFunctionsodium:proton antiporter activity

SLC9B1 SLC9A2

5.33e-0416432GO:0015385
GeneOntologyMolecularFunctionneurotransmitter transmembrane transporter activity

SLC18A3 SLC22A3

9.27e-0421432GO:0005326
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC25A38 SLC7A7 SLC25A13

1.50e-03105433GO:0015171
GeneOntologyMolecularFunctionmetal cation:proton antiporter activity

SLC9B1 SLC9A2

1.54e-0327432GO:0051139
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

SORT1 LIFR SMO TPRA1 RXFP1 CYSLTR1 HLA-DRB1 HLA-DRB3 RXFP2

2.03e-031353439GO:0004888
GeneOntologyMolecularFunctionG protein-coupled peptide receptor activity

RXFP1 CYSLTR1 RXFP2

2.93e-03133433GO:0008528
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

SLC9B1 CACNA1I SLC9A2 SLC11A2 SLC22A3

3.11e-03465435GO:0046873
GeneOntologyMolecularFunctionpeptide receptor activity

RXFP1 CYSLTR1 RXFP2

3.39e-03140433GO:0001653
GeneOntologyMolecularFunctionneutral L-amino acid transmembrane transporter activity

SLC25A38 SLC25A13

3.52e-0341432GO:0015175
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC25A38 SLC7A7 SLC22A3 SLC25A13

3.57e-03293434GO:0008514
GeneOntologyMolecularFunctionmetal cation:monoatomic cation antiporter activity

SLC9B1 SLC9A2

3.87e-0343432GO:0140828
GeneOntologyMolecularFunctionimmune receptor activity

LIFR HLA-DRB1 HLA-DRB3

5.37e-03165433GO:0140375
GeneOntologyMolecularFunctionantigen binding

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.91e-03190433GO:0003823
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC25A38 SLC7A7 SLC25A13

9.99e-03207433GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC25A38 SLC7A7 SLC25A13

1.01e-02208433GO:0005342
GeneOntologyBiologicalProcessMHC class II protein complex assembly

HLA-DRB1 HLA-DRB3 HLA-DRB4

4.97e-0616443GO:0002399
GeneOntologyBiologicalProcesspeptide antigen assembly with MHC class II protein complex

HLA-DRB1 HLA-DRB3 HLA-DRB4

4.97e-0616443GO:0002503
GeneOntologyBiologicalProcessMHC protein complex assembly

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.17e-0521443GO:0002396
GeneOntologyBiologicalProcesspeptide antigen assembly with MHC protein complex

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.17e-0521443GO:0002501
GeneOntologyBiologicalProcessmyeloid dendritic cell antigen processing and presentation

HLA-DRB1 HLA-DRB3

1.33e-053442GO:0002469
GeneOntologyBiologicalProcessproton transmembrane transport

SLC9B1 SLC9A2 SLC11A2 SLC18A3 SLC25A13

3.00e-05170445GO:1902600
GeneOntologyBiologicalProcessantigen processing and presentation of exogenous peptide antigen via MHC class II

HLA-DRB1 HLA-DRB3 HLA-DRB4

4.30e-0532443GO:0019886
GeneOntologyBiologicalProcessantigen processing and presentation of peptide antigen via MHC class II

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.16e-0536443GO:0002495
GeneOntologyBiologicalProcessantigen processing and presentation of peptide or polysaccharide antigen via MHC class II

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.25e-0538443GO:0002504
GeneOntologyBiologicalProcesspositive regulation of T cell mediated immune response to tumor cell

HLA-DRB1 HLA-DRB3

9.28e-057442GO:0002842
GeneOntologyBiologicalProcessdetection of biotic stimulus

SMO HLA-DRB1 NLRP3

1.29e-0446443GO:0009595
GeneOntologyBiologicalProcessantigen processing and presentation of exogenous peptide antigen

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.46e-0448443GO:0002478
GeneOntologyBiologicalProcessorganic cation transport

SLC25A38 SLC7A7 SLC18A3 SLC22A3

2.56e-04145444GO:0015695
GeneOntologyBiologicalProcesspositive regulation of CD4-positive, alpha-beta T cell activation

HLA-DRB1 NLRP3 HLA-DRB3

2.57e-0458443GO:2000516
GeneOntologyBiologicalProcessantigen processing and presentation of exogenous antigen

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.57e-0458443GO:0019884
GeneOntologyBiologicalProcessneutral amino acid transport

SLC25A38 SLC7A7 SLC25A13

2.85e-0460443GO:0015804
GeneOntologyBiologicalProcesspositive regulation of cell activation

RAG1 SMO HLA-DRB1 NLRP3 HLA-DRB3 HLA-DRB4

3.60e-04449446GO:0050867
GeneOntologyBiologicalProcesspositive regulation of T cell activation

RAG1 HLA-DRB1 NLRP3 HLA-DRB3 HLA-DRB4

3.68e-04290445GO:0050870
GeneOntologyBiologicalProcessserotonin uptake

SLC18A3 SLC22A3

3.98e-0414442GO:0051610
GeneOntologyBiologicalProcessregulation of T cell mediated immune response to tumor cell

HLA-DRB1 HLA-DRB3

3.98e-0414442GO:0002840
GeneOntologyBiologicalProcesspositive regulation of T cell mediated immunity

HLA-DRB1 NLRP3 HLA-DRB3

5.28e-0474443GO:0002711
GeneOntologyBiologicalProcesspositive regulation of leukocyte cell-cell adhesion

RAG1 HLA-DRB1 NLRP3 HLA-DRB3 HLA-DRB4

5.52e-04317445GO:1903039
GeneOntologyBiologicalProcessantigen processing and presentation of peptide antigen

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.71e-0476443GO:0048002
GeneOntologyBiologicalProcessendosomal transport

SORT1 SNX31 TMEM50A RGP1 VTI1B

5.76e-04320445GO:0016197
GeneOntologyBiologicalProcessT cell mediated immune response to tumor cell

HLA-DRB1 HLA-DRB3

5.93e-0417442GO:0002424
GeneOntologyBiologicalProcessnon-motile cilium assembly

IFT140 TMEM216 CC2D2B

6.16e-0478443GO:1905515
GeneOntologyBiologicalProcessvacuolar transport

SORT1 TMEM50A VPS33B VTI1B

6.69e-04187444GO:0007034
GeneOntologyBiologicalProcessL-alpha-amino acid transmembrane transport

SLC25A38 SLC7A7 SLC25A13

8.47e-0487443GO:1902475
GeneOntologyBiologicalProcesspositive regulation of alpha-beta T cell activation

HLA-DRB1 NLRP3 HLA-DRB3

9.05e-0489443GO:0046635
GeneOntologyBiologicalProcessdendritic cell antigen processing and presentation

HLA-DRB1 HLA-DRB3

9.10e-0421442GO:0002468
GeneOntologyBiologicalProcessGolgi to vacuole transport

SORT1 VTI1B

1.00e-0322442GO:0006896
GeneOntologyBiologicalProcessregulation of cell activation

RAG1 SMO VPS33B HLA-DRB1 NLRP3 HLA-DRB3 HLA-DRB4

1.01e-03756447GO:0050865
GeneOntologyBiologicalProcessregulation of intracellular pH

SLC9B1 SLC9A2 DMXL1

1.06e-0394443GO:0051453
GeneOntologyCellularComponentlate endosome membrane

SLC11A2 VPS33B HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

1.95e-06179446GO:0031902
GeneOntologyCellularComponentMHC class II protein complex

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.80e-0617443GO:0042613
GeneOntologyCellularComponentlate endosome

SMO SLC11A2 VPS33B HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

7.53e-06348447GO:0005770
GeneOntologyCellularComponentcoated vesicle

SORT1 VPS33B SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

9.39e-06360447GO:0030135
GeneOntologyCellularComponentclathrin-coated vesicle

SORT1 VPS33B SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4

9.81e-06237446GO:0030136
GeneOntologyCellularComponentER to Golgi transport vesicle membrane

HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

9.89e-0664444GO:0012507
GeneOntologyCellularComponentMHC protein complex

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.19e-0526443GO:0042611
GeneOntologyCellularComponentclathrin-coated endocytic vesicle membrane

SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4

2.29e-0579444GO:0030669
GeneOntologyCellularComponentautolysosome membrane

HLA-DRB1 HLA-DRB3

2.59e-054442GO:0120281
GeneOntologyCellularComponentlysosomal membrane

SORT1 SLC11A2 VPS33B HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

4.65e-05462447GO:0005765
GeneOntologyCellularComponentlytic vacuole membrane

SORT1 SLC11A2 VPS33B HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

4.65e-05462447GO:0098852
GeneOntologyCellularComponentlumenal side of endoplasmic reticulum membrane

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.43e-0535443GO:0098553
GeneOntologyCellularComponentclathrin-coated endocytic vesicle

SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4

6.01e-05101444GO:0045334
GeneOntologyCellularComponentendocytic vesicle membrane

SMO SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4

8.06e-05212445GO:0030666
GeneOntologyCellularComponentvacuolar membrane

SORT1 SLC11A2 VPS33B HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

8.34e-05507447GO:0005774
GeneOntologyCellularComponentCOPII-coated ER to Golgi transport vesicle

HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

8.38e-05110444GO:0030134
GeneOntologyCellularComponentcoated vesicle membrane

SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

8.61e-05215445GO:0030662
GeneOntologyCellularComponenttrans-Golgi network membrane

RGP1 HLA-DRB1 HLA-DRB3 HLA-DRB4

8.99e-05112444GO:0032588
GeneOntologyCellularComponenttransport vesicle

SORT1 VPS33B SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

9.65e-05519447GO:0030133
GeneOntologyCellularComponentlumenal side of membrane

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.41e-0448443GO:0098576
GeneOntologyCellularComponentendosome membrane

SORT1 SLC11A2 VPS33B HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

2.41e-04602447GO:0010008
GeneOntologyCellularComponentclathrin-coated vesicle membrane

SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4

2.56e-04147444GO:0030665
GeneOntologyCellularComponentGolgi apparatus subcompartment

SORT1 SLC11A2 RGP1 HLA-DRB1 HLA-DRB3 HLA-DRB4

3.12e-04443446GO:0098791
GeneOntologyCellularComponenttransport vesicle membrane

SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

3.63e-04293445GO:0030658
GeneOntologyCellularComponenttrans-Golgi network

SLC11A2 RGP1 HLA-DRB1 HLA-DRB3 HLA-DRB4

4.43e-04306445GO:0005802
GeneOntologyCellularComponentendosome

SORT1 SNX31 SMO SLC11A2 VPS33B HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

6.15e-041167449GO:0005768
GeneOntologyCellularComponentautolysosome

HLA-DRB1 HLA-DRB3

6.48e-0418442GO:0044754
GeneOntologyCellularComponentciliary transition zone

IFT140 TMEM216 CC2D2B

6.62e-0481443GO:0035869
GeneOntologyCellularComponentmembrane protein complex

CACNA1I CATSPERE GJE1 CLCN2 VPS33B SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

9.06e-0414984410GO:0098796
GeneOntologyCellularComponentplasma membrane protein complex

CACNA1I CATSPERE GJE1 SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4

1.17e-03785447GO:0098797
GeneOntologyCellularComponentendocytic vesicle

SMO SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4

1.23e-03384445GO:0030139
GeneOntologyCellularComponentsecondary lysosome

HLA-DRB1 HLA-DRB3

1.36e-0326442GO:0005767
GeneOntologyCellularComponentcytoplasmic vesicle membrane

SORT1 SMO SLC11A2 VPS33B SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

1.38e-031307449GO:0030659
GeneOntologyCellularComponentlysosome

SORT1 SLC11A2 VPS33B HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

1.41e-03811447GO:0005764
GeneOntologyCellularComponentlytic vacuole

SORT1 SLC11A2 VPS33B HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

1.41e-03811447GO:0000323
GeneOntologyCellularComponentvesicle membrane

SORT1 SMO SLC11A2 VPS33B SLC18A3 HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

1.51e-031325449GO:0012506
GeneOntologyCellularComponentvacuole

SORT1 SLC11A2 VPS33B HLA-DRB1 HLA-DRB3 HLA-DRB4 VTI1B

2.76e-03913447GO:0005773
GeneOntologyCellularComponenttrans-Golgi network transport vesicle

SORT1 SLC18A3

3.21e-0340442GO:0030140
GeneOntologyCellularComponentearly endosome

SORT1 SNX31 SLC11A2 VPS33B VTI1B

3.28e-03481445GO:0005769
GeneOntologyCellularComponentsperm principal piece

SLC9B1 CATSPERE

3.87e-0344442GO:0097228
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1I CATSPERE

4.23e-0346442GO:0005891
GeneOntologyCellularComponentglial cell projection

CLCN2 TMEM50A

4.41e-0347442GO:0097386
GeneOntologyCellularComponentciliary tip

IFT140 SMO

4.59e-0348442GO:0097542
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

SORT1 G6PC1 GRAMD4 HLA-DRB1 SLC22A3 HLA-DRB3 HLA-DRB4 VTI1B

5.90e-031327448GO:0042175
GeneOntologyCellularComponentneuronal cell body

SORT1 SMO CLCN2 TMEM50A SLC22A3 VTI1B

7.71e-03835446GO:0043025
GeneOntologyCellularComponentbasal part of cell

SLC11A2 CLCN2 SLC7A7 SLC22A3

8.08e-03378444GO:0045178
GeneOntologyCellularComponentearly endosome membrane

SLC11A2 VPS33B VTI1B

1.00e-02212443GO:0031901
GeneOntologyCellularComponentcalcium channel complex

CACNA1I CATSPERE

1.04e-0273442GO:0034704
GeneOntologyCellularComponentcilium

SLC9B1 IFT140 SMO CATSPERE TMEM216 CC2D2B

1.08e-02898446GO:0005929
GeneOntologyCellularComponentrecycling endosome

SLC11A2 VPS33B VTI1B

1.14e-02222443GO:0055037
GeneOntologyCellularComponentclathrin-coated pit

SORT1 SLC18A3

1.23e-0280442GO:0005905
GeneOntologyCellularComponentcell body

SORT1 SMO CLCN2 TMEM50A SLC22A3 VTI1B

1.27e-02929446GO:0044297
HumanPhenoAbnormal liver parenchyma morphology

VPS33B HLA-DRB1 SLC25A13

1.11e-0512203HP:0030146
HumanPhenoSleep terror

SMO SLC25A13

4.38e-053202HP:0030765
HumanPhenoAbnormal hepatocyte morphology

VPS33B SLC25A13

4.38e-053202HP:0034713
HumanPhenoNREM parasomnia

SMO HLA-DRB1 SLC25A13

5.66e-0520203HP:0025235
HumanPhenoAbnormal renal cortex morphology

RAG1 IFT140 SLC7A7 VPS33B G6PC1 HLA-DRB1 NLRP3

1.37e-04320207HP:0011035
HumanPhenoAbnormal circulating serine concentration

SLC7A7 SLC25A13

1.45e-045202HP:0012278
HumanPhenoElevated plasma citrulline

SLC7A7 SLC25A13

1.45e-045202HP:0011966
HumanPhenoAbnormal glomerular filtration rate

IFT140 SLC7A7 G6PC1

1.77e-0429203HP:0012212
HumanPhenoDecreased glomerular filtration rate

IFT140 SLC7A7 G6PC1

1.77e-0429203HP:0012213
MousePhenoabnormal spinal cord morphology

SORT1 LIFR SMO CLCN2 RGP1 FBXO45 SLC18A3

3.13e-06278337MP:0000955
DomainMHC_II_b_N

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.88e-078423PD000328
DomainMHC_II_beta

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.80e-079423PF00969
DomainMHC_II_b_N

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.80e-079423IPR000353
DomainMHC_II_beta

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.80e-079423SM00921
DomainMHC_II_a/b_N

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.78e-0614423IPR014745
Domain-

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.78e-06144233.10.320.10
DomainRelaxin_rcpt

RXFP1 RXFP2

4.94e-062422IPR008112
DomainMHC_I/II-like_Ag-recog

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.44e-0538423IPR011162
DomainC1-set

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.42e-0454423PF07654
DomainIGc1

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.70e-0456423SM00407
DomainIg_C1-set

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.99e-0458423IPR003597
DomainIg/MHC_CS

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.99e-0458423IPR003006
DomainIG_MHC

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.31e-0460423PS00290
DomainNa_H_Exchanger

SLC9B1 SLC9A2

4.42e-0414422PF00999
DomainCation/H_exchanger

SLC9B1 SLC9A2

4.42e-0414422IPR006153
DomainLDLR_class-A_CS

RXFP1 RXFP2

3.65e-0340422IPR023415
DomainLdl_recept_a

RXFP1 RXFP2

4.60e-0345422PF00057
Domain-

RXFP1 RXFP2

4.80e-03464224.10.400.10
DomainLDLRA_1

RXFP1 RXFP2

5.22e-0348422PS01209
DomainLDrepeatLR_classA_rpt

RXFP1 RXFP2

5.43e-0349422IPR002172
DomainLDLa

RXFP1 RXFP2

5.43e-0349422SM00192
DomainLDLRA_2

RXFP1 RXFP2

5.43e-0349422PS50068
DomainSOLCAR

SLC25A38 SLC25A13

6.33e-0353422PS50920
DomainMito_carr

SLC25A38 SLC25A13

6.33e-0353422PF00153
Domain-

SLC25A38 SLC25A13

6.33e-03534221.50.40.10
DomainMt_carrier_dom

SLC25A38 SLC25A13

6.33e-0353422IPR023395
DomainMitochondrial_sb/sol_carrier

SLC25A38 SLC25A13

6.33e-0353422IPR018108
DomainMFS

SLC18A3 SLC22A3

1.30e-0277422IPR011701
DomainMFS_1

SLC18A3 SLC22A3

1.30e-0277422PF07690
PathwayBIOCARTA_BBCELL_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.28e-0611353M22030
PathwayBIOCARTA_EOSINOPHILS_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.28e-0611353M22048
PathwayBIOCARTA_IL5_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.94e-0613353M18928
PathwayBIOCARTA_MHC_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.01e-0614353M22023
PathwayBIOCARTA_BLYMPHOCYTE_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.01e-0614353M1473
PathwayBIOCARTA_TCRA_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.01e-0614353M10765
PathwayKEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_NFY_MEDIATED_TRANSCRIPTION

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.25e-0615353M47588
PathwayKEGG_MEDICUS_REFERENCE_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_II_MOLECULES

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.25e-0615353M47604
PathwayBIOCARTA_ASBCELL_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.25e-0615353M7298
PathwayBIOCARTA_CSK_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.09e-0522353M6327
PathwayBIOCARTA_CTLA4_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.09e-0522353M1467
PathwayBIOCARTA_TH1TH2_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.40e-0523353M6705
PathwayREACTOME_PD_1_SIGNALING

HLA-DRB1 HLA-DRB3 HLA-DRB4

4.40e-0528353M18810
PathwayBIOCARTA_INFLAM_PATHWAY

HLA-DRB1 HLA-DRB3 HLA-DRB4

4.90e-0529353M6910
PathwayKEGG_ASTHMA

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.44e-0530353M13950
PathwayKEGG_ALLOGRAFT_REJECTION

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.03e-0437353M18615
PathwayREACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.21e-0439353M16523
PathwayKEGG_GRAFT_VERSUS_HOST_DISEASE

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.40e-0441353M13519
PathwayKEGG_TYPE_I_DIABETES_MELLITUS

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.62e-0443353M12617
PathwayREACTOME_RELAXIN_RECEPTORS

RXFP1 RXFP2

1.66e-048352M27371
PathwayKEGG_INTESTINAL_IMMUNE_NETWORK_FOR_IGA_PRODUCTION

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.25e-0448353M615
PathwayREACTOME_RELAXIN_RECEPTORS

RXFP1 RXFP2

2.66e-0410352MM15111
PathwayKEGG_AUTOIMMUNE_THYROID_DISEASE

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.85e-0452353M13103
PathwayKEGG_VIRAL_MYOCARDITIS

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.85e-0470353M12294
PathwayKEGG_LEISHMANIA_INFECTION

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.44e-0472353M3126
PathwayREACTOME_COSTIMULATION_BY_THE_CD28_FAMILY

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.05e-0474353M17386
PathwayKEGG_HEMATOPOIETIC_CELL_LINEAGE

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.29e-0387353M6856
PathwayKEGG_ANTIGEN_PROCESSING_AND_PRESENTATION

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.33e-0388353M16004
PathwayWP_BARDETBIEDL_SYNDROME

IFT140 SMO TMEM216

1.33e-0388353M45557
PathwayREACTOME_INTERFERON_GAMMA_SIGNALING

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.81e-0398353M965
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC9A2 SLC11A2 SLC7A7 SLC22A3

2.75e-03238354MM15076
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC9A2 SLC11A2 SLC7A7 SLC22A3

3.24e-03249354M5988
PathwayREACTOME_TCR_SIGNALING

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.54e-03124353M15381
PathwayREACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.70e-03126353M705
Pubmed

HLA-DR genotypes influence age at disease onset in children and juveniles with type 1 diabetes mellitus.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-09344320371654
Pubmed

Association of HLA-DR3 and HLA-DR4 with sinonasal polyposis in Mexican Mestizos.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-09344316815190
Pubmed

Binding domain regulation of MHC class II molecule assembly, trafficking, fate, and function.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-0934438775462
Pubmed

A male-specific increase in the HLA-DRB4 (DR53) frequency in high-risk and relapsed childhood ALL.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-09344312008082
Pubmed

Allelic variation in the DR subregion of the human major histocompatibility complex.

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.55e-0944433476943
Pubmed

HLA class II alleles in systemic sclerosis patients with anti-RNA polymerase I/III antibody: associations with subunit reactivities.

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.55e-09444314677183
Pubmed

Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link.

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.55e-09444319922436
Pubmed

Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes.

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.55e-09444326740600
Pubmed

Association of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB1*1501-DQB1*0602--positive subjects.

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.55e-09444317002906
Pubmed

HLA-DRB alleles and systemic lupus erythematosus in Jamaicans.

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.55e-09444312144077
Pubmed

Associations of human leukocyte antigen DRB with resistance or susceptibility to HIV-1 infection in the Pumwani Sex Worker Cohort.

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.55e-09444318520346
Pubmed

HLA DR B1*04, *07-restricted epitopes on Keratin 17 for autoreactive T cells in psoriasis.

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.55e-09444315795121
Pubmed

Antinuclear antibodies and HLA class II alleles in Jamaican patients with systemic lupus erythematosus.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544317910142
Pubmed

Major histocompatibility complex class II molecules promote human immunodeficiency virus type 1 assembly and budding to late endosomal/multivesicular body compartments.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544316973583
Pubmed

Genetic variability in HIV-1 gp120 affects interactions with HLA molecules and T cell receptor.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-0854431970352
Pubmed

Cross-reactive cytotoxic T lymphocytes induced by V3 loop synthetic peptides from different strains of human immunodeficiency virus type 1.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-0854437645219
Pubmed

A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestry.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544312392858
Pubmed

Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544315908298
Pubmed

HLA-DQ8 and the HLA-DQ8-DR4 haplotype are positively associated with the hevein-specific IgE immune response in health care workers with latex allergy.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544312209103
Pubmed

HLA-DQA is associated with abdominal aortic aneurysms in the Belgian population.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544317182961
Pubmed

HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544317763415
Pubmed

NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544311782380
Pubmed

Expansion of monocytic myeloid-derived suppressor cells dampens T cell function in HIV-1-seropositive individuals.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544323152536
Pubmed

HLA-DR-restricted peptides identified in the Nef protein can induce HIV type 1-specific IL-2/IFN-gamma-secreting CD4+ and CD4+ /CD8+ T cells in humans after lipopeptide vaccination.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544317411376
Pubmed

Productive human immunodeficiency virus type 1 assembly takes place at the plasma membrane.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544317507489
Pubmed

Competition of HLA-DR and a beta 2 domain peptide for HIV envelope glycoprotein gp120 binding to CD4.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-0854437734415
Pubmed

Visual hallucinations and HLA class II antigens in cortical dementia.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544320606439
Pubmed

HLA-DR and DQB1 gene polymorphism in the North-western Colombian population.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544312144632
Pubmed

HIV-1 gag polyprotein rescues HLA-DR intracellular transport in a human CD4+ cell line.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.89e-08544312202216
Pubmed

Frequency of concurrent autoimmune disorders in patients with autoimmune hepatitis: effect of age, gender, and genetic background.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.77e-08644318223493
Pubmed

Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.77e-08644319233472
Pubmed

Association of immune responses to mycobacterium tuberculosis peptide antigens with host genetic factors.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.77e-08644317153701
Pubmed

MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.77e-08644318305173
Pubmed

HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.77e-08644315902698
Pubmed

Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.77e-0864433372263
Pubmed

HLA risk markers for chronic myelogenous leukemia in Eastern Canada.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.77e-08644319235017
Pubmed

A comparison of molecular HLA-DR and DQ allele profiles forming DR51-, DR52-, and DR53-related haplotypes in five ethnic Thai populations from mainland southeast Asia.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.77e-08644311082517
Pubmed

Complete coding sequences and haplotypic associations of HLA-B*0707, -B*1524, -B*4405, -B*4802, -DRB1*0409, -DRB1*0411, -DRB1*1115, -DRB1*1305, and the novel allele -DRB1*0709. Group-specific amplification of cDNA from DRB1 alleles associated to DRB3 and DRB4.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.77e-08644315896200
Pubmed

HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.77e-08644311997714
Pubmed

HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.77e-08644314508706
Pubmed

Anti-cofactor autoantibodies in systemic lupus erythematosus: prevalence, clinical and HLA class II associations.

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.59e-08744318569076
Pubmed

The HIV core protein p24 inhibits interferon-gamma-induced increase of HLA-DR and cytochrome b heavy chain mRNA levels in the human monocyte-like cell line THP1.

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.59e-0874431905983
Pubmed

Human macrophages accumulate HIV-1 particles in MHC II compartments.

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.59e-08744312230470
Pubmed

[Human leukocyte antigen genes to genetic predisposition in diffuse panbronchiolitis].

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.59e-08744318846964
Pubmed

The impact of anti-HY responses on outcome in current and subsequent pregnancies of patients with recurrent pregnancy losses.

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.59e-08744320307907
Pubmed

Association of HY-restricting HLA class II alleles with pregnancy outcome in patients with recurrent miscarriage subsequent to a firstborn boy.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.05e-07844319223392
Pubmed

Correlation between HLA and pityriasis rosea susceptibility in Brazilian blacks.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.05e-07844316405603
Pubmed

HLA-A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP).

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.05e-07844312296785
Pubmed

Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.05e-07844317106278
Pubmed

Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.05e-07844323729440
Pubmed

Fusion of ubiquitin to HIV gag impairs human monocyte-derived dendritic cell maturation and reduces ability to induce gag T cell responses.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.58e-07944324505475
Pubmed

Major histocompatibility complex class-II molecules promote targeting of human immunodeficiency virus type 1 virions in late endosomes by enhancing internalization of nascent particles from the plasma membrane.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.58e-07944323170932
Pubmed

Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.25e-071044315784911
Pubmed

Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.25e-071044312956878
Pubmed

HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6.

HLA-DRB1 HLA-DRB3 HLA-DRB4

2.25e-07104438450224
Pubmed

Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.10e-071144321085635
Pubmed

Intracellular overexpression of HIV-1 Nef impairs differentiation and maturation of monocytic precursors towards dendritic cells.

HLA-DRB1 HLA-DRB3 HLA-DRB4

3.10e-071144322808111
Pubmed

HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4.

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.81e-07144437512597
Pubmed

HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56(dim) and CD56(bright) NK cell subsets.

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.81e-071444317431094
Pubmed

Interaction of CD4 with HLA class II antigens and HIV gp120.

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.81e-07144431869305
Pubmed

Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein.

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.50e-071544322860026
Pubmed

The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway.

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.50e-07154439079699
Pubmed

HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes.

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.50e-07154438376762
Pubmed

Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help.

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.50e-07154438168144
Pubmed

Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC.

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.50e-07154437602119
Pubmed

HIV-gp120 can block CD4-class II MHC-mediated adhesion.

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.50e-07154431967269
Pubmed

AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications.

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.50e-07154433489470
Pubmed

Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging.

HLA-DRB1 HLA-DRB3 HLA-DRB4

8.50e-071544310729169
Pubmed

Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.05e-06164432846691
Pubmed

Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.05e-06164432543930
Pubmed

Human immunodeficiency virus type 1 Vpu protein interacts with CD74 and modulates major histocompatibility complex class II presentation.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.05e-061644317959659
Pubmed

Tat protein induces self-perpetuating permissivity for productive HIV-1 infection.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.05e-06164439223324
Pubmed

Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.05e-06164431978941
Pubmed

Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.27e-061744325240755
Pubmed

HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.52e-061844319620308
Pubmed

Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.52e-061844311118314
Pubmed

Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.52e-061844310661406
Pubmed

Two distinct subtypes of the HLA-DRw12 haplotypes in the Japanese population detected by nucleotide sequence analysis and oligonucleotide genotyping.

HLA-DRB1 HLA-DRB4

1.56e-0624422592019
Pubmed

Paediatric celiac patients carrying the HLA-DR7-DQ2 and HLA-DR3-DQ2 haplotypes display small clinical differences.

HLA-DRB1 HLA-DRB3

1.56e-06244224628273
Pubmed

Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic.

HLA-DRB1 HLA-DRB4

1.56e-0624423596674
Pubmed

Mutations and selection in the generation of class II histocompatibility antigen polymorphism.

HLA-DRB1 HLA-DRB3

1.56e-0624426589154
Pubmed

DRB1*03 diversity and DRB3 associations in five major population groups in the United States.

HLA-DRB1 HLA-DRB3

1.56e-06244211872240
Pubmed

Structural organization of the DR subregion of the human major histocompatibility complex.

HLA-DRB1 HLA-DRB4

1.56e-0624423860851
Pubmed

A cellular and functional split in the DRw8 haplotype is due to a single amino acid replacement (DR beta ser 57- asp 57).

HLA-DRB1 HLA-DRB3

1.56e-0624422497068
Pubmed

HLA-DR4 as a risk allele for autism acting in mothers of probands possibly during pregnancy.

HLA-DRB1 HLA-DRB4

1.56e-06244219487610
Pubmed

Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice.

RXFP1 RXFP2

1.56e-06244222028476
Pubmed

HLA-DR association in papillary thyroid carcinoma.

HLA-DRB1 HLA-DRB4

1.56e-06244220164547
Pubmed

The conundrum of HLA-DRB1*14:01/*14:54 and HLA-DRB3*02:01/*02:02 mismatches in unrelated hematopoietic SCT.

HLA-DRB1 HLA-DRB3

1.56e-06244220972469
Pubmed

Identification of a novel HLA-DRB1 allele (HLA-DRB1*111902*).

HLA-DRB1 HLA-DRB4

1.56e-06244215982264
Pubmed

Development of a new HLA-DRB real-time PCR typing method.

HLA-DRB1 HLA-DRB3

1.56e-06244215620466
Pubmed

Sequence and evolution of HLA-DR7- and -DRw53-associated beta-chain genes.

HLA-DRB3 HLA-DRB4

1.56e-0624423110774
Pubmed

The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2.

RXFP1 RXFP2

1.56e-06244222973049
Pubmed

Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study.

HLA-DRB1 HLA-DRB4

1.56e-06244215140072
Pubmed

Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles.

HLA-DRB1 HLA-DRB3

1.56e-06244216320316
Pubmed

Description of two new HLA-DRB alleles (DRB1*0310 and DRB3*01012) found in a Spanish infant.

HLA-DRB1 HLA-DRB3

1.56e-0624429234492
Pubmed

T cell receptors recognizing type II collagen in HLA-DR-transgenic mice characterized by highly restricted V beta usage.

HLA-DRB1 HLA-DRB4

1.56e-06244215188377
Pubmed

Tracking antigen-specific T-cells during clinical tolerance induction in humans.

HLA-DRB1 HLA-DRB3

1.56e-06244220543955
Pubmed

Resolving the unconventional mechanisms underlying RXFP1 and RXFP2 receptor function.

RXFP1 RXFP2

1.56e-06244219416161
Pubmed

Modeling the primary hormone-binding site of RXFP1 and RXFP2.

RXFP1 RXFP2

1.56e-06244219416162
Pubmed

Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis.

HLA-DRB1 HLA-DRB3

1.56e-06244216200610
Cytoband11q13.1

PCNX3 TMEM216

1.77e-036345211q13.1
Cytoband6p21.3

HLA-DRB1 HLA-DRB3 HLA-DRB4

1.91e-032504536p21.3
GeneFamilySolute carriers

SLC25A38 SLC9B1 SLC9A2 SLC11A2 SLC7A7 SLC18A3 SLC22A3 SLC25A13

5.34e-07395348752
GeneFamilyRelaxin family peptide receptors

RXFP1 RXFP2

2.05e-054342217
GeneFamilyC1-set domain containing

HLA-DRB1 HLA-DRB3 HLA-DRB4

6.63e-0542343591
GeneFamilyHistocompatibility complex|C1-set domain containing

HLA-DRB1 HLA-DRB3 HLA-DRB4

7.63e-0544343588
CoexpressionSOBOLEV_PBMC_PANDEMRIX_AGE_18_64YO_1DY_UP

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.75e-0621443M41167
CoexpressionGSE22501_PERIPHERAL_BLOOD_VS_CORD_BLOOD_TREG_DN

EEF2 TTC39A SLC11A2 CLCN2 G6PC1

2.05e-05199445M8367
CoexpressionPARENT_MTOR_SIGNALING_UP

SLC25A38 IFT140 EEF2 SLC11A2 RGP1 HLA-DRB1 HLA-DRB4

4.09e-05567447M16909
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

EEF2 B3GNTL1 SLC7A7 RGP1 NLRP3

5.53e-07166435063d68f2ffb40770cb4601fa1cb6426ae26f7a37
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Junb_(Microglia)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

EEF2 B3GNTL1 SLC7A7 RGP1 NLRP3

5.53e-07166435417cfb207da08fa1a0fd5f2a13c8786628667a8e
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI2(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Junb_(Microglia)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

EEF2 B3GNTL1 SLC7A7 RGP1 NLRP3

5.53e-07166435f28d07715e6b00ca2a0df39273c5f569744be5a8
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Myeloid|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 SLC7A7 CYSLTR1 NLRP3

2.53e-0517743456fe389ffab73e3bc64f837b152d5907e3517a91
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Myeloid-microglial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 SLC7A7 CYSLTR1 NLRP3

2.53e-05177434201b0a8e6402a18aff0bb7c14f2bdd34fdf0db32
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Myeloid-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 SLC7A7 CYSLTR1 NLRP3

2.53e-051774342a63288d09efd217b277aeecf957811a095f56e7
ToppCell18-Distal-Immune-Hematopoietic,_Macrophage|Distal / Age, Tissue, Lineage and Cell class

SLC7A7 CYSLTR1 HLA-DRB1 NLRP3

3.48e-05192434e54577183b09599a3b2bdd532a18ea8f4a6e3524
ToppCellwk_08-11-Hematologic-Myeloid-CX3CR1+_Mac|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SLC7A7 CYSLTR1 HLA-DRB1 NLRP3

3.55e-05193434afc20433b5abc9b430751a2aa8d93b0fd136a888
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SLC7A7 CYSLTR1 HLA-DRB1 NLRP3

3.70e-05195434e8fb552f9ab77b656c27abc66af523b56cd9f9ad
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_monocytic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SLC7A7 CYSLTR1 HLA-DRB1 NLRP3

3.77e-05196434b904f3a6d6a93e149f5a1b34b6adad5c7894754d
ToppCellwk_08-11-Hematologic|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SLC7A7 CYSLTR1 HLA-DRB1 NLRP3

4.00e-05199434edc9afd7be8543cb93a2bb874a14aad0417dfa92
ToppCellsevere-Myeloid-CD14_Monocytes_1|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

EEF2 SLC7A7 HLA-DRB1 NLRP3

4.00e-05199434ce07b7c1edfc6e2136dafcf041361b66a52271d3
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SORT1 COL6A3 SLC7A7 HLA-DRB1

4.08e-05200434efdbd1273b07d9fe957380e347b5b6b45db0a271
ToppCellTracheal-10x5prime-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SORT1 COL6A3 SLC7A7 HLA-DRB1

4.08e-052004349ca86928fceaa1fefd0f9ffcfa5cc0a210ee5792
ToppCellwk_08-11-Hematologic-Myeloid|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SLC7A7 CYSLTR1 HLA-DRB1 NLRP3

4.08e-05200434148e09e27e4a563bdd1fbe9a593cd938885cbb1b
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Ngfr_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SNX31 RXFP1 SLC18A3

6.83e-05824331ed7d7f70f00d6e280cd59c54e710bb724c8b50b
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Ngfr_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SNX31 RXFP1 SLC18A3

6.83e-0582433a5d3c5b7012d8ca7418670242d22aad3ed8c5191
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

SNX31 RXFP1 SLC18A3

6.83e-0582433cefd8c6f60ef27fb8823faddca1cf8bbd636f474
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_1|Thalamus / BrainAtlas - Mouse McCarroll V32

SLC9B1 SLC9A2 G6PC1

1.59e-041094334e4a884b8979f4ff8b232c1581ea78884dda29ed
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Prdm8|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SNX31 TTC39A GJE1

2.16e-041214332ae870f822488799cd0ad85e7f72af64e33a867f
ToppCellASK440-Endothelial-Endothelium|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq

LIFR RXFP1 HLA-DRB1

2.22e-041224332f76ec3b527e9528fbb006599a96e8bbdf9e0e62
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Stem_cells-neuroepithelial-like_cells|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

SLC9B1 ANKEF1 DNMT3B

2.50e-041274339071cd0953c8bb6746dc9cd13d153e3d6ef40b08
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia)-|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

COL6A3 CYSLTR1 NLRP3

3.99e-04149433406a5ccfedbf43543f0346ff7ef3ce1d15c38f29
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

COL6A3 CYSLTR1 NLRP3

3.99e-0414943334a3075af794052763fc7c4135f3031f89da5caa
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

COL6A3 CYSLTR1 NLRP3

3.99e-04149433be698ecce34ddbdf57d08082b71268934675e74e
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA-MI1(C1qb)-Tmem119-MICROGLIA_Microglia.C1qb.Tmem119-Fos_(Microglia)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

COL6A3 CYSLTR1 NLRP3

3.99e-04149433183c77cc8f23b8406e7241a066cb684470002a3b
ToppCellNS-moderate-d_0-4-Myeloid-Monocyte-derived_DC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SLC7A7 HLA-DRB1 VTI1B

4.23e-04152433ce944f7c1444fd0cb793db183b96818e37342b24
ToppCellfacs-BAT-Fat-24m-Lymphocytic-NK_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX31 PCNX3 VPS33B

4.47e-04155433550e7e7e52829244ead829e5be010bfdc71e2ba5
ToppCell10x5'v1-week_12-13-Myeloid_DC-DC-DC2|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

SLC9A2 RXFP1 HLA-DRB1

4.56e-0415643303f3c5ffb27758fe63797143fcc938f9e8a4e10d
ToppCellfacs-Spleen-nan-3m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORT1 SNX31 NLRP3

4.56e-04156433f532ef4e92ac7661b1a8a4f2e98d80ce8d4e3655
ToppCellfacs-Spleen-nan-3m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORT1 SNX31 NLRP3

4.56e-04156433da4f35353a84d919e683554932f110e29568df33
ToppCellfacs-Spleen-nan-3m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SORT1 SNX31 NLRP3

4.56e-04156433f1e25ff85c5f2f8555f9fb5ae5daed7ddb418fd1
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-lymphocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39A CYSLTR1 NLRP3

4.91e-041604335c28121916a12dbc22ef2421040bdc9148a40b78
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage_2|368C / Donor, Lineage, Cell class and subclass (all cells)

SORT1 SLC7A7 HLA-DRB1

4.91e-04160433ac3f56f8ab8efd11c4b4868a828db05c23ac762f
ToppCelldroplet-Kidney-nan-3m-Lymphocytic-CD45|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39A CYSLTR1 NLRP3

4.91e-04160433b7093678987575f2f99d648821d31b4a37075aca
ToppCellfacs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX31 IFT140 CLCN2

5.09e-0416243314e9f8aaba308619eb9da90796c336e76cedac1f
ToppCellfacs-Marrow-KLS-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX31 IFT140 CLCN2

5.09e-04162433860ebf2390b4ad86475ad54717cbefcf61cd3b2a
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD8_low_T|T/NK_cells / Location, Cell class and cell subclass

RAG1 B3GNTL1 HLA-DRB1

5.27e-0416443392fb94492fc2b683e9d50a9db6f01d23c194b0e4
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC9B1 CACNA1I DNMT3B

5.46e-0416643326f3d5e5e30b63b09b89cda23c423d12d887631f
ToppCellAdult-Mesenchymal-myofibroblast_cell|Adult / Lineage, Cell type, age group and donor

COL6A3 SMO TMEM216

5.56e-04167433d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|390C / Donor, Lineage, Cell class and subclass (all cells)

FBXO45 HLA-DRB1 DNMT3B

5.75e-04169433cfc9ff103d13a2d5eacc457e800f53fdd29f7738
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

HLA-DRB1 NLRP3 CC2D2B

5.75e-04169433a0681317867e31319210a23e56660a53f4529efe
ToppCellwk_08-11-Hematologic_Lymphocytic-B-Late_pro-B|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RAG1 CYSLTR1 HLA-DRB1

5.85e-04170433ad69ebfda452e19eedc453e1d07dacb844d64e47
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RAG1 RXFP1 CLCN2

5.95e-041714332a34685f7d83d1cf9a88d304173cbca868c5f9fd
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

HLA-DRB1 NLRP3 CC2D2B

6.06e-04172433ac20766d1fd43eab8c3ff5e7418a6b38bebf0bd5
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

HLA-DRB1 NLRP3 CC2D2B

6.06e-041724333fd1bc4a8ced0bf9e26ca4ce6d83b5b97bbc2556
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC25A38 IFT140 ANKEF1

6.06e-041724338a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

FBXO45 HLA-DRB1 DNMT3B

6.16e-04173433b9dee61973559e8c2fef3f2dafd43475b386befb
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

SORT1 SLC7A7 CYSLTR1

6.16e-0417343342c911ed16fabdabef063830e8407192d8bde950
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR CYSLTR1 CC2D2B

6.16e-04173433b57d14e2c2368304cb903562d06ce8228f53857c
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 SLC11A2 SLC7A7

6.26e-041744334cdf2eedc28d88d18241ee390092426fdf849e79
ToppCellfacs-Marrow-B-cells-18m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 SLC11A2 SLC7A7

6.26e-04174433268be5e7d2a18b866770b7cdb966c3958c7e6534
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D231|Adult / Lineage, Cell type, age group and donor

LIFR RXFP1 CC2D2B

6.26e-041744332dd647c4fdf99fd1f7b838efef01baf2cbc3446d
ToppCell11.5-Distal-Immune-Hematopoietic,_B_Cells|Distal / Age, Tissue, Lineage and Cell class

RAG1 CYSLTR1 HLA-DRB1

6.37e-04175433d8ca8fbe5309dab293c335b32f1b138edfdd0b07
ToppCell3'_v3-GI_small-bowel-Myeloid_Mac-Macrophage|GI_small-bowel / Manually curated celltypes from each tissue

SORT1 SLC7A7 HLA-DRB1

6.47e-041764334be270f6bb7da4070f972aca403109751646d155
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FBXO45 HLA-DRB1 DNMT3B

6.47e-04176433437cfc5e06416bb0fc76d1f9dc106f74e279e880
ToppCelldroplet-Marrow-BM-30m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A38 IFT140 SLC11A2

6.58e-04177433d1af0cb4b1fb03f04cff5add85e29be8fb8f4dcb
ToppCelldroplet-Marrow-BM-30m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A38 IFT140 SLC11A2

6.58e-04177433650095a17e1a39caea74a6e89646565b9332af5d
ToppCellPosterior_cortex-Hematopoietic|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SLC7A7 CYSLTR1 NLRP3

6.69e-04178433ea9e4f461dda34c0ebc707d7dbefc7a49ce5bb55
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39A SLC18A3 CYSLTR1

6.69e-041784338c5e9fab7b55a654ccaabf2c4d02397399d94616
ToppCell3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-cDC2|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CYSLTR1 HLA-DRB1 NLRP3

6.69e-041784338184a2b9872f7ca12a9823535de485e841aeffb1
ToppCellPosterior_cortex-Hematopoietic-MICROGLIA|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SLC7A7 CYSLTR1 NLRP3

6.80e-041794335122fc794509492afde4af8b1b76d51e3070ef05
ToppCelldroplet-Marrow-BM-1m-Hematologic-hematopoietic_precursor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SMO SLC22A3 DNMT3B

6.91e-04180433ff34195bb7325e61fbf823c103c5e6115d8f1248
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

LIFR RXFP1 CC2D2B

6.91e-0418043327e8bbee388e64dd79d70b160b76d45b1f398006
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR CLCN2 CYSLTR1

7.02e-04181433d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

RAG1 CYSLTR1 HLA-DRB1

7.02e-0418143351e4d6bfdbf414d8e30aee2e6f7492f4f7f54373
ToppCell11.5-Airway-Immune-Hematopoietic,_B_Cells|Airway / Age, Tissue, Lineage and Cell class

RAG1 CYSLTR1 HLA-DRB1

7.02e-04181433727344d7b2953568b7b3463398c7d56878cf2c2b
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR CLCN2 CYSLTR1

7.02e-04181433e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 RXFP1 RXFP2

7.13e-0418243344764676ed3f51ba171ce63f669390392fa50a43
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 RXFP1 RXFP2

7.13e-04182433d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LIFR DNMT3B CC2D2B

7.25e-0418343352af3c943116073c8ddd207b664342960b88929b
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Monocytic-Nonclassical_Monocyte|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC7A7 HLA-DRB1 SLC25A13

7.25e-041834334cc0961a67de76b8d756cd9ffcaa98e3fe3c3a69
ToppCellPBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SORT1 SLC7A7 NLRP3

7.25e-04183433fcb0f755382d88fb207fc2322cd224c09c6e2ea6
ToppCellControl-Endothelial_cells-Pulmonary_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

LIFR RXFP1 CC2D2B

7.25e-0418343346be9f96755c7b65aeac061d95d15abeb6466034
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_pre-Lymphocytic-T|lymph-node_spleen / Manually curated celltypes from each tissue

TPRA1 B3GNTL1 DNMT3B

7.25e-041834336c55fd737ed31f5b1aa41dc4dba7240521c19022
ToppCellPBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SORT1 SLC7A7 NLRP3

7.25e-041834334763df29c888d47c22076803b054f06b4cc29368
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EEF2 SLC7A7 G6PC1

7.36e-041844332b83c7a808e97abf836f53aa3243543c8f6762fb
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Lymphocytic-T_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A3 SLC25A13 DNMT3B

7.36e-04184433185b49630da61cbf45c0926d1b992943296d2a54
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_prolif-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

GRAMD4 CYSLTR1 CC2D2B

7.48e-0418543330b7a738d91f4292d5572a50c352563e8529b8da
ToppCelldroplet-Thymus|droplet / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 SMO EEF2

7.48e-0418543383a78d17ad59503a694c1250082c4d8ae74d63e1
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_B-im_B_cell_(15)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

RAG1 CYSLTR1 HLA-DRB1

7.48e-041854338fc357ee041bfd588986730a52ea2021b5f88941
ToppCelldroplet-Marrow-nan-18m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A38 IFT140 CLCN2

7.48e-04185433a45756f91b62cf0fac3582786e5868deb8fd8435
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-nan|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAG1 EEF2 TMEM50A

7.48e-041854337acc071ea75442817db4d98bd3ed3fff6f0a9d46
ToppCellmetastatic_Brain-Myeloid_cells-Alveolar_Mac|metastatic_Brain / Location, Cell class and cell subclass

SLC7A7 HLA-DRB1 NLRP3

7.60e-041864339270e04c61b743874424a5935537b62e7d89c461
ToppCellwk_08-11-Hematologic-Myeloid-Cycling_DC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

SLC7A7 HLA-DRB1 NLRP3

7.60e-04186433de1f0bc5dbf6dc0e716f5ebbf2bbcfe249811c54
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC9A2 RXFP1 SLC22A3

7.60e-04186433337f768cc43db2db96ba6495b076006b1a5b0331
ToppCellPCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

CYSLTR1 HLA-DRB1 NLRP3

7.60e-041864336575ec6a626cdea169ffd185d47828dfaa29475d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

B3GNTL1 HLA-DRB1 NLRP3

7.60e-04186433305f1726b8b5add32f1c29c74991ff34f42e0da7
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC9A2 RXFP1 SLC22A3

7.60e-04186433e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TTC39A GRAMD4 SLC22A3

7.60e-04186433b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCelldroplet-Marrow-nan-21m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A38 IFT140 SLC11A2

7.60e-041864336e6998f5ccb1b2628048a21e8d3053e020569aba
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

LIFR RXFP1 CC2D2B

7.72e-04187433e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Lymphocytic|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A3 SLC25A13 DNMT3B

7.72e-04187433e53471c3e146a6f54788d81ecc469aba55b051bb
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Lymphocytic-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC22A3 SLC25A13 DNMT3B

7.72e-041874333d7d51fbadb20dc884d0b3c0d61b80f022b19d09
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_macrophage|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

COL6A3 SLC7A7 HLA-DRB1

7.84e-041884332e268d8091e25d50bf05f26517d3ceb583801fd4
ToppCelldroplet-Marrow-BM-30m-Hematologic-erythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A38 IFT140 SLC11A2

7.84e-04188433f1a9d8ea174a4bef0fae8188e3bd96b7ac1a39bb
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD163+CD14+_DCs|metastatic_Lymph_Node / Location, Cell class and cell subclass

SLC7A7 HLA-DRB1 NLRP3

7.84e-041884335d12afb483d028ca02b3b4215131f6128e8bcd48
ToppCell10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

COL6A3 SLC7A7 HLA-DRB1

7.84e-0418843359d5c7b147af118442adadf708ce2d1422b1e9aa
ToppCellPCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_migrating_dendritic_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CYSLTR1 HLA-DRB1 NLRP3

7.84e-041884338fc15c8b78fdd1a578e34325011bc5a87a8aab31
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

LIFR RXFP1 CC2D2B

7.84e-04188433d582b76fc2faac526c9bf97503041129e1a6a211
Diseaseaspirin-induced respiratory disease (is_implicated_in)

HLA-DRB1 HLA-DRB3 HLA-DRB4

5.06e-0711443DOID:0080822 (is_implicated_in)
Diseasechylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

HLA-DRB1 SLC22A3 RXFP2

1.79e-0534443EFO_0008317, EFO_0008596, EFO_0020947
DiseaseDrug Allergy

CYSLTR1 HLA-DRB1 NLRP3

1.96e-0535443C0013182
Diseaseextranodal nasal NK/T cell lymphoma

HLA-DRB1 HLA-DRB3

3.25e-056442MONDO_0019472
Diseaseurticaria (is_implicated_in)

HLA-DRB1 NLRP3

6.05e-058442DOID:1555 (is_implicated_in)
Diseaseglaucoma (is_implicated_in)

EEF2 HLA-DRB1

9.71e-0510442DOID:1686 (is_implicated_in)
DiseaseCakut

LIFR VPS33B

1.68e-0413442C1968949
Diseaseautoimmune thrombocytopenic purpura (is_implicated_in)

HLA-DRB1 DNMT3B

2.25e-0415442DOID:8924 (is_implicated_in)
Diseaseallergic disease (is_implicated_in)

CYSLTR1 HLA-DRB1

2.25e-0415442DOID:1205 (is_implicated_in)
DiseaseHodgkins lymphoma

CACNA1I SLC18A3 HLA-DRB1

2.52e-0482443EFO_0000183
Diseasehepatitis B virus infection

HLA-DRB1 HLA-DRB3

3.66e-0419442EFO_0004197
DiseaseArthrogryposis

VPS33B SLC18A3

4.48e-0421442C0003886
DiseasePolydactyly

IFT140 SMO TMEM216

7.15e-04117443C0152427
DiseaseMalignant neoplasm of breast

EEF2 SLC9A2 CATSPERE SLC7A7 G6PC1 ANKEF1 DNMT3B

9.79e-041074447C0006142
Diseasesystemic lupus erythematosus

COL6A3 SMO PCNX3 HIBCH HLA-DRB1 HLA-DRB3

1.14e-03799446MONDO_0007915
Diseasesystolic blood pressure, body mass index

TPRA1 SLC22A3

1.18e-0334442EFO_0004340, EFO_0006335

Protein segments in the cluster

PeptideGeneStartEntry
YIKSFRGFIRLGGIV

CATSPERE

306

Q5SY80
RKGLYEGTGRLFFEF

DNMT3B

661

Q9UBC3
LVGLAVGLYAGIKFF

GRAMD4

356

Q6IC98
VGLYAGIKFFLIDFI

GRAMD4

361

Q6IC98
AKGGFFDILKLLFAY

ANKEF1

226

Q9NU02
NFFLYFGKKALVLLG

CC2D2B

1191

Q6DHV5
LISGGRKGFTYVFDL

DMXL1

2901

Q9Y485
FALFKRVVFGLGRLG

C17orf113

561

A0A1B0GUU1
GILRTFKFIFRGTGY

RAG1

696

P15918
RLQGKLGYFLALTGF

HIBCH

186

Q6NVY1
FLYGLHALFKGDFRI

PCNX3

1606

Q9H6A9
KYGLRKLEAFFGFLI

SLC11A2

201

P49281
FLGAGLFIYFRNQKG

HLA-DRB3

241

P79483
GYEFLGVAFRGLPKV

FBXO45

246

P0C2W1
LFSFAIGFYLLLKGL

G6PC1

216

P35575
FFIIFGILGVQLFKG

CACNA1I

1316

Q9P0X4
GYFFVVLGIGRKVNI

COL6A3

2766

P12111
LFFGSIRIFFLGVLG

GJE1

26

A6NN92
IRIFFLGVLGFAVYG

GJE1

31

A6NN92
FLGAGLFIYFRNQKG

HLA-DRB1

241

P01911
FLGTGLFIYFRNQKG

HLA-DRB4

241

P13762
DKGRFYAFGRVFSGL

EEF2

406

P13639
RLGIIGGNLYIDFFI

SLC22A3

371

O75751
GFYTKGRALDLLAGF

IFT140

1271

Q96RY7
ELRGFLRGYLFYFGK

LIFR

751

P42702
GKFEKGYLIFVVRFL

NLRP3

566

Q96P20
VKIYSFGLGGRFLFA

SORT1

301

Q99523
FGGILYEFAGKRVPF

SLC18A3

231

Q16572
FFGGLVFKFGRTEDL

TMEM50A

141

O95807
GKVGTFGIFKSVYRL

RGP1

221

Q92546
VYLFFVGIFDIKYRG

RXFP2

466

Q8WXD0
LIFKDYGLRGFFQGG

SLC25A38

261

Q96DW6
LLGYFGLFLIRFGKE

SNX31

156

Q8N9S9
LLFFYEHLRKGGGVI

B3GNTL1

206

Q67FW5
LSVVRDLGFFGIYKG

SLC25A13

471

Q9UJS0
VGFFGNGFVLYVLIK

CYSLTR1

36

Q9Y271
SGFGGALFVYLNRKI

CLCN2

331

P51788
YVAFLRGFFGSEPKI

TPRA1

276

Q86W33
FKDQFIIAYGGLRGA

SLC9A2

426

Q9UBY0
YILEAFGGFLAFIRL

SLC7A7

106

Q9UM01
IYLFVIGGFDLKFRG

RXFP1

456

Q9HBX9
FGLFIIFYSAIIGGK

SLC9B1

96

Q4ZJI4
RLGIFGFLAFGFVLI

SMO

451

Q99835
YLGIEVIRLFFGTKG

TMEM216

66

Q9P0N5
YPKGAIFLFFAGRIE

TTC39A

311

Q5SRH9
ELAILGGLVYYKFFR

VTI1B

216

Q9UEU0
FLGREKGYRFIFLTT

VPS33B

586

Q9H267