Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of neurotransmitter secretion	NLGN1 SLC4A8 BGLAP	2.16e-05	25	45	3	GO:0001956
GeneOntologyBiologicalProcess	auditory receptor cell stereocilium organization	TRIOBP STRC STRCP1	2.44e-05	26	45	3	GO:0060088
GeneOntologyBiologicalProcess	auditory receptor cell morphogenesis	TRIOBP STRC STRCP1	4.18e-05	31	45	3	GO:0002093
GeneOntologyBiologicalProcess	positive regulation of neurotransmitter transport	NLGN1 SLC4A8 BGLAP	4.60e-05	32	45	3	GO:0051590
GeneOntologyBiologicalProcess	positive regulation of synaptic vesicle exocytosis	NLGN1 SLC4A8	4.63e-05	5	45	2	GO:2000302
GeneOntologyBiologicalProcess	auditory receptor cell development	TRIOBP STRC STRCP1	9.06e-05	40	45	3	GO:0060117
GeneOntologyBiologicalProcess	inner ear receptor cell stereocilium organization	TRIOBP STRC STRCP1	2.11e-04	53	45	3	GO:0060122
GeneOntologyBiologicalProcess	protein localization to lysosome	GPR137B SZT2 RTN4	3.04e-04	60	45	3	GO:0061462
GeneOntologyBiologicalProcess	epidermal cell differentiation	PTCH2 TRIOBP STRC STRCP1 TMEM79	3.72e-04	284	45	5	GO:0009913
GeneOntologyBiologicalProcess	glutamate receptor clustering	GRIP2 NLGN1	4.17e-04	14	45	2	GO:0097688
GeneOntologyBiologicalProcess	AMPA glutamate receptor clustering	GRIP2 NLGN1	4.17e-04	14	45	2	GO:0097113
GeneOntologyBiologicalProcess	inner ear auditory receptor cell differentiation	TRIOBP STRC STRCP1	4.22e-04	67	45	3	GO:0042491
GeneOntologyCellularComponent	actin-based cell projection	TRIOBP NLGN1 STRC ADGRA2 STRCP1	3.52e-04	278	46	5	GO:0098858
GeneOntologyCellularComponent	kinocilium	STRC STRCP1	4.24e-04	14	46	2	GO:0060091
GeneOntologyCellularComponent	9+2 non-motile cilium	STRC STRCP1	4.24e-04	14	46	2	GO:0097732
GeneOntologyCellularComponent	stereocilium	TRIOBP STRC STRCP1	4.72e-04	69	46	3	GO:0032420
GeneOntologyCellularComponent	stereocilium bundle	TRIOBP STRC STRCP1	7.01e-04	79	46	3	GO:0032421
GeneOntologyCellularComponent	stereocilium tip	STRC STRCP1	1.06e-03	22	46	2	GO:0032426
Domain	Carboxylesterase_B_CS	CES4A NLGN1	4.55e-04	13	46	2	IPR019819
Domain	COesterase	CES4A NLGN1	5.30e-04	14	46	2	PF00135
Domain	CARBOXYLESTERASE_B_2	CES4A NLGN1	5.30e-04	14	46	2	PS00941
Domain	CarbesteraseB	CES4A NLGN1	5.30e-04	14	46	2	IPR002018
Domain	PH	TRIOBP ARHGEF18 PHETA1 ARHGEF1 DGKK	5.87e-04	278	46	5	SM00233
Domain	PH_DOMAIN	TRIOBP ARHGEF18 PHETA1 ARHGEF1 DGKK	5.96e-04	279	46	5	PS50003
Domain	PH_domain	TRIOBP ARHGEF18 PHETA1 ARHGEF1 DGKK	6.06e-04	280	46	5	IPR001849
Domain	PH	TRIOBP ARHGEF18 PHETA1 DGKK	2.40e-03	229	46	4	PF00169
Domain	-	TRIOBP ARHGEF18 PHETA1 ARHGEF1 DGKK	2.65e-03	391	46	5	2.30.29.30
Domain	FHA_dom	FHAD1 RASIP1	3.54e-03	36	46	2	IPR000253
Domain	-	FHAD1 RASIP1	3.54e-03	36	46	2	2.60.200.20
Domain	PH_dom-like	TRIOBP ARHGEF18 PHETA1 ARHGEF1 DGKK	3.83e-03	426	46	5	IPR011993
Domain	SMAD_FHA_domain	FHAD1 RASIP1	7.28e-03	52	46	2	IPR008984
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	1.87e-06	2	48	2	34910522
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	1.87e-06	2	48	2	11687802
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	5.59e-06	3	48	2	30801007
Pubmed	CCAAT/enhancer-binding protein delta activates the Runx2-mediated transcription of mouse osteocalcin II promoter.	CEBPD BGLAP	5.59e-06	3	48	2	16720721
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	1.12e-05	4	48	2	18849963
Pubmed	Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho.	MAP3K10 ARHGEF1	1.12e-05	4	48	2	15753034
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	1.86e-05	5	48	2	24920589
Pubmed	A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.	SLC4A8 STRC STRCP1	2.01e-05	38	48	3	38346162
Pubmed	Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS.	ARHGEF1 RTN4	3.90e-05	7	48	2	12951563
Pubmed	The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI.	ARHGEF1 RTN4	5.19e-05	8	48	2	12692556
Pubmed	Roles of glial p75NTR in axonal regeneration.	ARHGEF1 RTN4	5.19e-05	8	48	2	17335080
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	5.19e-05	8	48	2	21165971
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	1.02e-04	11	48	2	31776257
Pubmed	Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.	PTCH2 BGLAP	1.02e-04	11	48	2	10465785
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	1.02e-04	11	48	2	31448880
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	BOP1 PHETA1 ZNF579 SNAPC4 WIZ CHRNA4 ARHGEF1 RTN4	1.39e-04	1124	48	8	21900206
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	2.50e-04	17	48	2	20856818
Pubmed	Pinin modulates expression of an intestinal homeobox gene, Cdx2, and plays an essential role for small intestinal morphogenesis.	PTCH2 CDX1	3.49e-04	20	48	2	20637749
Pubmed	Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature.	XIRP1 GRIP2	4.63e-04	23	48	2	23117660
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZNF579 SNAPC4 WIZ SZT2 ADGRA2 TMEM94 SPEG	7.57e-04	1105	48	7	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TRIOBP BOP1 SZT2 ADGRA2 RTN4	7.98e-04	529	48	5	14621295
Cytoband	15q15.3	STRC STRCP1	3.16e-04	25	48	2	15q15.3
Cytoband	1q22	BGLAP TMEM79	1.65e-03	57	48	2	1q22
Cytoband	1p36.21	FHAD1 PRDM2	2.01e-03	63	48	2	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	BGLAP TMEM79	2.54e-03	71	48	2	chr1q22
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIOBP ARHGEF18 PHETA1	5.18e-03	206	31	3	682
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF18 ARHGEF1	5.70e-03	66	31	2	722
ToppCell	E18.5-samps-Mesenchymal-Pericyte-pericyte_C\|E18.5-samps / Age Group, Lineage, Cell class and subclass	XIRP1 GRIP2 SLC4A8 ADAMTSL3 DGKK	6.07e-07	151	48	5	3f2abaa42876ce7a71d934ff16abe0cab0991a05
Drug	Pyrantel tartrate [33401-94-4]; Down 200; 11.2uM; HL60; HG-U133A	TRIOBP RITA1 SNAPC4 ADGRA2 TMEM94 ARHGEF1	2.68e-06	192	47	6	1413_DN
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	2.27e-06	2	45	2	DOID:0110471 (implicated_via_orthology)
Disease	Anorectal Malformations	CDX1 NLGN1	1.80e-03	41	45	2	C3495676
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	TRIOBP STRC	2.77e-03	51	45	2	cv:CN043650
Disease	response to simvastatin, total cholesterol change measurement, response to fenofibrate	TRIOBP NLGN1	2.77e-03	51	45	2	EFO_0007806, GO_1901557, GO_1903491
Disease	Nonsyndromic genetic hearing loss	TRIOBP STRC	6.03e-03	76	45	2	cv:C5680182
Disease	Antihypertensive use measurement	ARHGEF18 NLGN1 KLF13	7.70e-03	265	45	3	EFO_0009927

Protein segments in the cluster

Peptide	Gene	Start	Entry
AFVPPEEPPLQPARW	BOP1	501	Q14137
APRFWPEPEGEPPAT	CHRNA4	381	P43681
GPAPPWLPSPIGEEE	BEST2	491	Q8NFU1
EPEEPPGWRELVPPD	ARHGEF1	391	Q92888
DPRPRDWRGPPNSPD	ARHGEF18	936	Q6ZSZ5
VEPAPAPPTAWGAPF	CDX1	51	P47902
WRAPPPQEGDPALPT	ADGRA2	866	Q96PE1
PPAAWDPPPAEREAV	RASIP1	881	Q5U651
PAAEPEPAWEEAPPE	CDRT15	101	Q96T59
DGEQPAESPEPPPPW	DGKK	16	Q5KSL6
PAEPSPGARAPWEPT	MAP3K10	641	Q02779
GSPPEPLFPNDWDPL	LMTK3	546	Q96Q04
PLFPNDWDPLDPGVP	LMTK3	551	Q96Q04
PGPAEPLDDWGPLFR	CDH24	791	Q86UP0
PGWFLDSPDRPWNPP	PDCD1	21	Q15116
RWPEAPPPPADVLGD	PDCD7	121	Q8N8D1
LGILRFAPPEPPEPW	CES4A	61	Q5XG92
FAPPEPPEPWKGIRD	CES4A	66	Q5XG92
GERRFQPPEPPSPWS	NLGN1	91	Q8N2Q7
WLGAPVPYPDPLEPR	BGLAP	56	P02818
ENPPPVSFPWMRGPA	FHAD1	96	B1AJZ9
PWPAEPAPFYEPGRA	CEBPD	16	P49716
PEETWVPEPSGPLRP	DENND4B	26	O75064
APPSPAWSEPEPEAG	KLF13	116	Q9Y2Y9
DDWEPPTSPAPGPAR	GRIP2	851	Q9C0E4
WREPPPPYPCIETGD	NTAQ1	156	Q96HA8
PPPGPWSLPRAEGEA	CDC37L1	6	Q7L3B6
TPAPAWEPQPEPDER	PRDM2	241	Q13029
SAPGPMETPPWDPAR	GPR137B	11	O60478
AAPPVAPERQPSWDP	RTN4	96	Q9NQC3
PGWQPDEPVVPRPFL	SZT2	66	Q5T011
WSTEATFRPGPEPPP	PHETA1	191	Q8N4B1
GAYIHPAPDEPPWSP	PTCH2	1171	Q9Y6C5
PLTVPFPPTWAEDPG	WIZ	846	O95785
LPPGEWDPSIRIEPP	SLC4A8	396	Q2Y0W8
EAHRAFPPPSTPPWE	TEX45	81	Q8NA69
WEPPEARAPSATPRP	PM20D2	91	Q8IYS1
PEGLPPVPLTPDIFW	STRC	456	Q7RTU9
AEPPHPWSPEKRPEG	TRIOBP	1371	Q9H2D6
RPTPPDFDPPWVEKA	RITA1	46	Q96K30
LSPPEEFPEPGETWP	SPEG	831	Q15772
RGDWPGEAPKPPEPY	TMEM94	486	Q12767
APFPDPPGWRDIEPE	TMEM79	86	Q9BSE2
PPGWRDIEPEPPESE	TMEM79	91	Q9BSE2
DASLDPEAPWPPAPR	TNFSF9	6	P41273
VPAGFWGPVEADRPP	ZNF843	121	Q8N446
PEAEPPWSGRLPAFG	SNAPC4	1196	Q5SXM2
PEGLPPVPLTPDIFW	STRCP1	456	A6NGW2
DAAPARPPAGEPRFW	ZNF579	371	Q8NAF0
WEPPADPSPVPASEG	XIRP1	946	Q702N8
PPPEPPTESAWERGL	ZC3H18	291	Q86VM9
DPTGEPPPQEPFWEP	ADAMTSL3	1416	P82987