Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	alpha-tocopherol omega-hydroxylase activity	CYP4F3 CYP4F12 CYP4F11	2.49e-06	5	127	3	GO:0052871
GeneOntologyMolecularFunction	leukotriene-B4 20-monooxygenase activity	CYP4F3 CYP4F12 CYP4F11	8.63e-06	7	127	3	GO:0050051
GeneOntologyMolecularFunction	alkane 1-monooxygenase activity	CYP4F3 CYP4F12 CYP4F11	8.63e-06	7	127	3	GO:0018685
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE4B PDE4D PDE8A PDE9A	1.04e-05	22	127	4	GO:0004115
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE4B PDE4D PDE8A PDE9A	1.50e-05	24	127	4	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE4B PDE4D PDE8A PDE9A	1.78e-05	25	127	4	GO:0004114
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE4B PDE4D PDE8A PDE9A	2.45e-05	27	127	4	GO:0004112
GeneOntologyMolecularFunction	arachidonate omega-hydroxylase activity	CYP4F3 CYP4F12 CYP4F11	2.92e-05	10	127	3	GO:0052869
GeneOntologyMolecularFunction	fatty acid omega-hydroxylase activity	CYP4F3 CYP4F12 CYP4F11	2.92e-05	10	127	3	GO:0120250
GeneOntologyMolecularFunction	long-chain fatty acid omega-hydroxylase activity	CYP4F3 CYP4F12 CYP4F11	2.92e-05	10	127	3	GO:0102033
GeneOntologyMolecularFunction	protein-tyrosine sulfotransferase activity	TPST2 TPST1	4.01e-05	2	127	2	GO:0008476
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen	CYP4F3 CYP4F12 CYP4F11	6.86e-05	13	127	3	GO:0016713
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PDE4B PDE4D PDE8A PDE9A PLCG1	3.88e-04	97	127	5	GO:0008081
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP4F3 CYP4F12 CYP4F11	4.61e-04	24	127	3	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP4F3 CYP4F12 CYP4F11	6.57e-04	27	127	3	GO:0008391
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	CACNA1B CACNA1E	1.40e-03	9	127	2	GO:0099511
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	CACNA1B CACNA1E	1.40e-03	9	127	2	GO:0099626
GeneOntologyMolecularFunction	aromatase activity	CYP4F3 CYP4F12 CYP4F11	1.42e-03	35	127	3	GO:0070330
GeneOntologyMolecularFunction	tubulin binding	PDE4B STRBP DAG1 SYBU DCTN1 CCT5 MTUS1 TRAPPC14 MX1	1.68e-03	428	127	9	GO:0015631
GeneOntologyBiologicalProcess	long-chain fatty acid catabolic process	LIPE CYP4F3 CYP4F12 CYP4F11	5.93e-07	12	124	4	GO:0042758
GeneOntologyBiologicalProcess	cyclic nucleotide catabolic process	PDE4B PDE4D PDE8A PDE9A	1.19e-06	14	124	4	GO:0009214
GeneOntologyBiologicalProcess	leukotriene B4 catabolic process	CYP4F3 CYP4F12 CYP4F11	4.19e-06	6	124	3	GO:0036101
GeneOntologyBiologicalProcess	leukotriene B4 metabolic process	CYP4F3 CYP4F12 CYP4F11	7.29e-06	7	124	3	GO:0036102
GeneOntologyBiologicalProcess	leukotriene catabolic process	CYP4F3 CYP4F12 CYP4F11	1.16e-05	8	124	3	GO:0036100
GeneOntologyBiologicalProcess	protein sulfation	CHST5 TPST2 TPST1	1.16e-05	8	124	3	GO:0006477
GeneOntologyBiologicalProcess	cAMP catabolic process	PDE4B PDE4D PDE8A	1.74e-05	9	124	3	GO:0006198
GeneOntologyBiologicalProcess	icosanoid catabolic process	CYP4F3 CYP4F12 CYP4F11	3.38e-05	11	124	3	GO:1901523
GeneOntologyBiologicalProcess	regulation of system process	CACNA1B CACNA1E TSHZ3 PDE4B PDE4D PDE9A AVPR2 DAG1 RYR2 SLC25A12 KCNJ3 SCN5A MFN2 BAIAP2 RIMS2	3.52e-05	734	124	15	GO:0044057
GeneOntologyBiologicalProcess	peptidyl-tyrosine sulfation	TPST2 TPST1	3.59e-05	2	124	2	GO:0006478
GeneOntologyBiologicalProcess	negative regulation of relaxation of cardiac muscle	PDE4B PDE4D	3.59e-05	2	124	2	GO:1901898
GeneOntologyBiologicalProcess	actin filament-based movement	PDE4B PDE4D WAS RYR2 MYO5C KCNJ3 SCN5A	3.93e-05	153	124	7	GO:0030048
GeneOntologyBiologicalProcess	cellular response to epinephrine stimulus	PDE4B PDE4D RYR2	7.35e-05	14	124	3	GO:0071872
GeneOntologyBiologicalProcess	leukotriene metabolic process	PLA2G4A CYP4F3 CYP4F12 CYP4F11	1.06e-04	41	124	4	GO:0006691
GeneOntologyBiologicalProcess	menaquinone catabolic process	CYP4F12 CYP4F11	1.07e-04	3	124	2	GO:0042361
GeneOntologyBiologicalProcess	regulation of cardiac muscle cell contraction	PDE4B PDE4D RYR2 SCN5A	1.28e-04	43	124	4	GO:0086004
GeneOntologyBiologicalProcess	response to epinephrine	PDE4B PDE4D RYR2	1.36e-04	17	124	3	GO:0071871
GeneOntologyBiologicalProcess	cyclic purine nucleotide metabolic process	PDE4B PDE4D PDE8A PDE9A	1.40e-04	44	124	4	GO:0052652
GeneOntologyBiologicalProcess	organelle fusion	CACNA1B USP30 HUWE1 MFN2 PLA2G4A RIMS2 VCPIP1	1.53e-04	190	124	7	GO:0048284
GeneOntologyBiologicalProcess	cyclic nucleotide metabolic process	PDE4B PDE4D PDE8A PDE9A	1.53e-04	45	124	4	GO:0009187
GeneOntologyBiologicalProcess	cellular catabolic process	HYAL4 USP30 LRSAM1 HUWE1 EPX ABCA7 SESN1 EPG5 BLMH AGXT2 VPS13D LIPE MFN2 PLA2G4A CYP4F3 CYP4F12 PLCG1 CYP4F11 ULK2	1.73e-04	1253	124	19	GO:0044248
GeneOntologyBiologicalProcess	atrial cardiac muscle cell to AV node cell communication	RYR2 KCNJ3 SCN5A	1.92e-04	19	124	3	GO:0086066
GeneOntologyBiologicalProcess	atrial cardiac muscle cell to AV node cell signaling	RYR2 KCNJ3 SCN5A	1.92e-04	19	124	3	GO:0086026
GeneOntologyBiologicalProcess	atrial cardiac muscle cell action potential	RYR2 KCNJ3 SCN5A	1.92e-04	19	124	3	GO:0086014
GeneOntologyBiologicalProcess	menaquinone metabolic process	CYP4F12 CYP4F11	2.13e-04	4	124	2	GO:0009233
GeneOntologyBiologicalProcess	phylloquinone metabolic process	CYP4F12 CYP4F11	2.13e-04	4	124	2	GO:0042374
GeneOntologyBiologicalProcess	phylloquinone catabolic process	CYP4F12 CYP4F11	2.13e-04	4	124	2	GO:0042376
GeneOntologyBiologicalProcess	vitamin K catabolic process	CYP4F12 CYP4F11	2.13e-04	4	124	2	GO:0042377
GeneOntologyBiologicalProcess	positive regulation of vesicle fusion	CACNA1B PLA2G4A RIMS2	2.24e-04	20	124	3	GO:0031340
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	PDE4B PDE4D RYR2 KCNJ3 SCN5A	2.47e-04	93	124	5	GO:0086003
GeneOntologyBiologicalProcess	regulation of actin filament-based movement	PDE4B PDE4D RYR2 SCN5A	2.90e-04	53	124	4	GO:1903115
GeneOntologyBiologicalProcess	fatty acid derivative catabolic process	CYP4F3 CYP4F12 CYP4F11	3.00e-04	22	124	3	GO:1901569
GeneOntologyBiologicalProcess	cell communication involved in cardiac conduction	PDE4D RYR2 KCNJ3 SCN5A	4.39e-04	59	124	4	GO:0086065
GeneOntologyBiologicalProcess	cAMP metabolic process	PDE4B PDE4D PDE8A	4.43e-04	25	124	3	GO:0046058
GeneOntologyBiologicalProcess	Purkinje myocyte to ventricular cardiac muscle cell communication	RYR2 SCN5A	5.29e-04	6	124	2	GO:0086068
GeneOntologyBiologicalProcess	prostaglandin catabolic process	CYP4F12 CYP4F11	5.29e-04	6	124	2	GO:1905344
GeneOntologyBiologicalProcess	Purkinje myocyte to ventricular cardiac muscle cell signaling	RYR2 SCN5A	5.29e-04	6	124	2	GO:0086029
GeneOntologyBiologicalProcess	prostanoid catabolic process	CYP4F12 CYP4F11	5.29e-04	6	124	2	GO:0062232
GeneOntologyBiologicalProcess	sulfation	CHST5 TPST2 TPST1	5.58e-04	27	124	3	GO:0051923
GeneOntologyBiologicalProcess	heart process	CACNA1B CACNA1E PDE4B PDE4D RYR2 KCNJ3 SCN5A AKAP13	5.68e-04	309	124	8	GO:0003015
GeneOntologyBiologicalProcess	autophagy of mitochondrion	USP30 HUWE1 VPS13D MFN2 ULK2	6.30e-04	114	124	5	GO:0000422
GeneOntologyBiologicalProcess	regulation of calcium-dependent activation of synaptic vesicle fusion	CACNA1B RIMS2	7.38e-04	7	124	2	GO:0150037
GeneOntologyBiologicalProcess	establishment of mitotic sister chromatid cohesion	STAG1 STAG2	7.38e-04	7	124	2	GO:0034087
GeneOntologyBiologicalProcess	negative regulation of relaxation of muscle	PDE4B PDE4D	7.38e-04	7	124	2	GO:1901078
GeneOntologyBiologicalProcess	arachidonate metabolic process	PLA2G4A CYP4F3 CYP4F12 CYP4F11	7.53e-04	68	124	4	GO:0019369
GeneOntologyBiologicalProcess	regulation of heart contraction	CACNA1B CACNA1E PDE4B PDE4D RYR2 KCNJ3 SCN5A	7.80e-04	249	124	7	GO:0008016
GeneOntologyBiologicalProcess	regulation of blood circulation	CACNA1B CACNA1E PDE4B PDE4D AVPR2 RYR2 KCNJ3 SCN5A	8.05e-04	326	124	8	GO:1903522
GeneOntologyCellularComponent	perinuclear region of cytoplasm	PDE4B PDE4D PDE8A PDE9A AVPR2 NDFIP2 EPG5 STK16 ASL CEP250 CPEB4 SCN5A PLA2G4A COBL AKAP13 HEATR5B MX1	5.10e-05	934	127	17	GO:0048471
GeneOntologyCellularComponent	calcium channel complex	CACNA1B CACNA1E PDE4B PDE4D RYR2	8.25e-05	73	127	5	GO:0034704
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1B CACNA1E PDE4B PDE4D	1.74e-04	46	127	4	GO:0005891
GeneOntologyCellularComponent	ruffle	PDE9A ABCA7 APPL2 COBL PLCG1 BAIAP2 MTSS2	2.68e-04	206	127	7	GO:0001726
GeneOntologyCellularComponent	supramolecular fiber	PDE4B PDE4D WAS DAG1 SYBU DCTN1 TUBG1 RYR2 DNAH1 CCT5 MTUS1 SCN5A COBL AKAP13 BAIAP2 MYO18B MX1 PCNT	2.77e-04	1179	127	18	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	PDE4B PDE4D WAS DAG1 SYBU DCTN1 TUBG1 RYR2 DNAH1 CCT5 MTUS1 SCN5A COBL AKAP13 BAIAP2 MYO18B MX1 PCNT	3.00e-04	1187	127	18	GO:0099081
GeneOntologyCellularComponent	ruffle membrane	PDE9A ABCA7 APPL2 PLCG1 MTSS2	5.17e-04	108	127	5	GO:0032587
GeneOntologyCellularComponent	cation channel complex	CACNA1B CACNA1E PDE4B PDE4D RYR2 KCNJ3 SCN5A	5.92e-04	235	127	7	GO:0034703
GeneOntologyCellularComponent	mitotic cohesin complex	STAG1 STAG2	7.54e-04	7	127	2	GO:0030892
GeneOntologyCellularComponent	cell leading edge	PDE9A DAG1 DCTN1 ABCA7 TUBG1 APPL2 COBL PLCG1 BAIAP2 MTSS2	9.66e-04	500	127	10	GO:0031252
Domain	PDEase	PDE4B PDE4D PDE8A PDE9A	7.53e-06	19	128	4	IPR023088
Domain	PDEase_I	PDE4B PDE4D PDE8A PDE9A	1.15e-05	21	128	4	PF00233
Domain	PDEASE_I	PDE4B PDE4D PDE8A PDE9A	1.15e-05	21	128	4	PS00126
Domain	PDEase_CS	PDE4B PDE4D PDE8A PDE9A	1.15e-05	21	128	4	IPR023174
Domain	-	PDE4B PDE4D PDE8A PDE9A	1.40e-05	22	128	4	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE4B PDE4D PDE8A PDE9A	1.68e-05	23	128	4	IPR002073
Domain	HD/PDEase_dom	PDE4B PDE4D PDE8A PDE9A	2.01e-05	24	128	4	IPR003607
Domain	HDc	PDE4B PDE4D PDE8A PDE9A	2.01e-05	24	128	4	SM00471
Domain	TPST	TPST2 TPST1	4.66e-05	2	128	2	IPR026634
Domain	DUF4599	SPATA31D4 SPATA31D1 SPATA31D3	6.61e-05	12	128	3	PF15371
Domain	DUF4599	SPATA31D4 SPATA31D1 SPATA31D3	6.61e-05	12	128	3	IPR027970
Domain	ARM-type_fold	STAG1 MROH2A USP24 HUWE1 TEX10 NOM1 PRKDC HEATR5B STAG2 GPRASP2	1.16e-04	339	128	10	IPR016024
Domain	Histatin/statherin	HTN1 HTN3	1.39e-04	3	128	2	IPR030773
Domain	SCD	STAG1 STAG2	2.77e-04	4	128	2	PS51425
Domain	SCD	STAG1 STAG2	2.77e-04	4	128	2	IPR020839
Domain	STAG	STAG1 STAG2	2.77e-04	4	128	2	PF08514
Domain	CEBP_ZZ	CPEB3 CPEB4	2.77e-04	4	128	2	PF16366
Domain	RRM_7	CPEB3 CPEB4	2.77e-04	4	128	2	PF16367
Domain	CEBP_ZZ	CPEB3 CPEB4	2.77e-04	4	128	2	IPR032296
Domain	STAG	STAG1 STAG2	2.77e-04	4	128	2	IPR013721
Domain	IMD	BAIAP2 MTSS2	4.60e-04	5	128	2	PS51338
Domain	ARM-like	STAG1 MROH2A HUWE1 TEX10 PRKDC HEATR5B STAG2 GPRASP2	5.52e-04	270	128	8	IPR011989
Domain	WH2	WAS COBL MTSS2	5.73e-04	24	128	3	PS51082
Domain	IMD	BAIAP2 MTSS2	6.87e-04	6	128	2	PF08397
Domain	Ca_chan_IQ	CACNA1B CACNA1E	9.57e-04	7	128	2	SM01062
Domain	Ca_chan_IQ	CACNA1B CACNA1E	9.57e-04	7	128	2	PF08763
Domain	VDCC_a1su_IQ	CACNA1B CACNA1E	9.57e-04	7	128	2	IPR014873
Domain	GPHH	CACNA1B CACNA1E	9.57e-04	7	128	2	PF16905
Domain	GPHH_dom	CACNA1B CACNA1E	9.57e-04	7	128	2	IPR031649
Domain	HEAT_REPEAT	MROH2A TEX10 PRKDC HEATR5B	1.36e-03	70	128	4	PS50077
Domain	Sulfotransfer_1	CHST5 TPST2 TPST1	1.90e-03	36	128	3	PF00685
Domain	Sulfotransferase_dom	CHST5 TPST2 TPST1	1.90e-03	36	128	3	IPR000863
Domain	VDCCAlpha1	CACNA1B CACNA1E	2.02e-03	10	128	2	IPR002077
Domain	UBA	USP24 HUWE1 VPS13D	3.39e-03	44	128	3	IPR015940
Domain	I-BAR_dom	BAIAP2 MTSS2	3.46e-03	13	128	2	IPR013606
Domain	Cyt_P450_E_grp-I	CYP4F3 CYP4F12 CYP4F11	3.62e-03	45	128	3	IPR002401
Domain	G_DYNAMIN_dom	MFN2 MX1	4.02e-03	14	128	2	IPR030381
Domain	G_DYNAMIN_2	MFN2 MX1	4.02e-03	14	128	2	PS51718
Domain	WH2	WAS COBL	4.02e-03	14	128	2	SM00246
Domain	UBA	USP24 HUWE1 VPS13D	4.09e-03	47	128	3	PS50030
Domain	Dynamin_GTPase	MFN2 MX1	4.62e-03	15	128	2	IPR001401
Domain	Dynamin_SF	MFN2 MX1	4.62e-03	15	128	2	IPR022812
Domain	Dynamin_N	MFN2 MX1	4.62e-03	15	128	2	PF00350
Domain	WH2	WAS COBL	5.25e-03	16	128	2	PF02205
Domain	Cyt_P450_CS	CYP4F3 CYP4F12 CYP4F11	5.74e-03	53	128	3	IPR017972
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1B CACNA1E RYR2	4.41e-05	11	93	3	M47958
Pathway	REACTOME_EICOSANOIDS	CYP4F3 CYP4F12 CYP4F11	5.86e-05	12	93	3	M27129
Pathway	REACTOME_EICOSANOIDS	CYP4F3 CYP4F12 CYP4F11	5.86e-05	12	93	3	MM14845
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYCLOOXYGENASES_COX	PLA2G4A CYP4F3 CYP4F12 CYP4F11	6.27e-05	33	93	4	MM15918
Pathway	WP_EICOSANOID_METABOLISM_VIA_CYTOCHROME_P450_MONOOXYGENASES	CYP4F3 CYP4F12 CYP4F11	9.60e-05	14	93	3	MM15842
Pathway	REACTOME_AURKA_ACTIVATION_BY_TPX2	DCTN1 TUBG1 CEP250 PLK4 PCNT	1.11e-04	72	93	5	M27749
Pathway	REACTOME_FATTY_ACIDS	CYP4F3 CYP4F12 CYP4F11	1.19e-04	15	93	3	M27126
Pathway	REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES	DCTN1 TUBG1 CEP250 PLK4 PCNT	1.93e-04	81	93	5	M748
Pathway	REACTOME_MISCELLANEOUS_SUBSTRATES	CYP4F3 CYP4F12 CYP4F11	2.11e-04	18	93	3	MM14843
Pathway	REACTOME_FATTY_ACIDS	CYP4F3 CYP4F12 CYP4F11	2.11e-04	18	93	3	MM14841
Pathway	REACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION	DCTN1 TUBG1 CEP250 PLK4 PCNT	2.70e-04	87	93	5	M27194
Pathway	WP_G_PROTEIN_SIGNALING_PATHWAYS	PDE4B PDE4D PDE8A KCNJ3 AKAP13	3.17e-04	90	93	5	MM15882
Pathway	WP_G_PROTEIN_SIGNALING	PDE4B PDE4D PDE8A KCNJ3 AKAP13	3.33e-04	91	93	5	M39426
Pathway	REACTOME_MITOTIC_PROMETAPHASE	STAG1 DCTN1 TUBG1 CEP250 PLK4 STAG2 PCNT	3.97e-04	204	93	7	M4217
Pathway	REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES	DCTN1 TUBG1 CEP250 PLK4 PCNT	4.07e-04	95	93	5	M6729
Pathway	REACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE	DCTN1 TUBG1 CEP250 PLK4 PCNT	4.48e-04	97	93	5	M27478
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	PDE4B PDE4D PDE8A PDE9A	4.68e-04	55	93	4	M39763
Pathway	REACTOME_SYNTHESIS_OF_LEUKOTRIENES_LT_AND_EOXINS_EX	CYP4F3 CYP4F12 CYP4F11	5.75e-04	25	93	3	MM14858
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	PLA2G4A CYP4F3 CYP4F12 CYP4F11	6.95e-04	61	93	4	MM14861
Pathway	KEGG_MEDICUS_REFERENCE_ESTABLISHMENT_OF_COHESION	STAG1 STAG2	8.85e-04	7	93	2	M47869
Pathway	REACTOME_DEFECTIVE_FACTOR_VIII_CAUSES_HEMOPHILIA_A	TPST2 TPST1	8.85e-04	7	93	2	M39000
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TPST2 RHBDF2 LRRK1 HUWE1 DCTN1 ABCA7 TUBG1 FAM20C POMGNT2 PCNX4 SCN5A MFN2 COBL AKAP13 PLCG1 PRKDC ULK2 PRRC2B PCNT	2.81e-08	1105	129	19	35748872
Pubmed	Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.	PDE4B PDE4D PDE8A PDE9A	1.76e-07	14	129	4	25852085
Pubmed	Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.	CYP4F3 CYP4F12 CYP4F11	1.99e-07	4	129	3	18065749
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	GAPVD1 CCDC50 PARD3B DCTN1 AGO1 CCT5 MTUS1 KIAA1217 CEP250 COBL BAIAP2 PLEKHA7 PRRC2B PCNT VCPIP1	6.92e-07	853	129	15	28718761
Pubmed	The cytochrome P450 4 (CYP4) family.	CYP4F3 CYP4F12 CYP4F11	9.89e-07	6	129	3	9068972
Pubmed	The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis.	TUBG1 PLK4 PCNT	9.89e-07	6	129	3	18207742
Pubmed	Rebuilding essential active zone functions within a synapse.	CACNA1B CACNA1E RIMS2	1.73e-06	7	129	3	35176221
Pubmed	The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion.	DCTN1 TUBG1 CEP250 PLK4 PCNT	2.13e-06	56	129	5	11076968
Pubmed	Overview of PDEs and their regulation.	PDE4B PDE4D PDE8A PDE9A	2.15e-06	25	129	4	17307970
Pubmed	The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.	DCTN1 TUBG1 CEP250 PLK4 PCNT	2.33e-06	57	129	5	16462731
Pubmed	Centrosome-related genes, genetic variation, and risk of breast cancer.	MCM2 DCTN1 TUBG1 CEP250 PLK4 PCNT	2.33e-06	102	129	6	20508983
Pubmed	Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.	DCTN1 TUBG1 CEP250 PLK4 PCNT	2.54e-06	58	129	5	12852856
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PDE4D PDE9A RHBDF2 PARD3B HUWE1 SESN1 DNAH1 PLEKHG4B PCNX4 KCNJ3 KIAA1217 TOX3 COBL AKAP13 PLCG1 BAIAP2 CYP4F11 STAG2 PCNT	2.59e-06	1489	129	19	28611215
Pubmed	Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.	DCTN1 TUBG1 CEP250 PLK4 PCNT	3.27e-06	61	129	5	7790358
Pubmed	Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.	DCTN1 TUBG1 CEP250 PLK4 PCNT	4.84e-06	66	129	5	12221128
Pubmed	Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.	PDE4B PDE4D PCNT	1.07e-05	12	129	3	19251251
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	GAPVD1 LEMD3 USP24 DAG1 NDFIP2 HUWE1 TEX10 TUBG1 SLC25A12 PRKDC HEATR5B STAG2 GPRASP2 VCPIP1	1.13e-05	942	129	14	31073040
Pubmed	STAG Mutations in Cancer.	STAG1 STAG2	1.37e-05	2	129	2	31421907
Pubmed	Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study.	PDE4B PDE4D	1.37e-05	2	129	2	31324945
Pubmed	Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells.	STAG1 STAG2	1.37e-05	2	129	2	32778134
Pubmed	Physical parameters of hydroxyapatite adsorption and effect on candidacidal activity of histatins.	HTN1 HTN3	1.37e-05	2	129	2	12711380
Pubmed	Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation.	RYR2 SCN5A	1.37e-05	2	129	2	23723061
Pubmed	Overexpression of phosphodiesterase-4 subtypes involved in surgery-induced neuroinflammation and cognitive dysfunction in mice.	PDE4B PDE4D	1.37e-05	2	129	2	28235598
Pubmed	Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance.	CACNA1B CACNA1E	1.37e-05	2	129	2	15610184
Pubmed	Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway.	WAS PLCG1	1.37e-05	2	129	2	25758716
Pubmed	Nuclear import and export signals of human cohesins SA1/STAG1 and SA2/STAG2 expressed in Saccharomyces cerevisiae.	STAG1 STAG2	1.37e-05	2	129	2	22715410
Pubmed	Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1.	STAG1 STAG2	1.37e-05	2	129	2	28430577
Pubmed	Structural relationship between human salivary histatins.	HTN1 HTN3	1.37e-05	2	129	2	2303595
Pubmed	Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody.	TPST2 TPST1	1.37e-05	2	129	2	17046811
Pubmed	Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.	STAG1 STAG2	1.37e-05	2	129	2	24324008
Pubmed	Salivary gland hypofunction in tyrosylprotein sulfotransferase-2 knockout mice is due to primary hypothyroidism.	TPST2 TPST1	1.37e-05	2	129	2	23951251
Pubmed	Shear stress mediates tyrosylprotein sulfotransferase isoform shift in human endothelial cells.	TPST2 TPST1	1.37e-05	2	129	2	12056800
Pubmed	Localization of the genes for histatins to human chromosome 4q13 and tissue distribution of the mRNAs.	HTN1 HTN3	1.37e-05	2	129	2	2773933
Pubmed	PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.	PDE4B PDE4D	1.37e-05	2	129	2	21288894
Pubmed	Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2.	TPST2 TPST1	1.37e-05	2	129	2	18672380
Pubmed	Tyrosylprotein sulfotransferase-2 expression is required for sulfation of RNase 9 and Mfge8 in vivo.	TPST2 TPST1	1.37e-05	2	129	2	19047058
Pubmed	Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4.	PDE4B PDE4D	1.37e-05	2	129	2	29123207
Pubmed	GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine epitopes reactive with CTD110.6 antibody.	DAG1 POMGNT2	1.37e-05	2	129	2	24041696
Pubmed	Tyrosine sulfation is a trans-Golgi-specific protein modification.	TPST2 TPST1	1.37e-05	2	129	2	3121635
Pubmed	Lack of protein-tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy.	TPST2 TPST1	1.37e-05	2	129	2	21039965
Pubmed	Purkinje Cells as Sources of Arrhythmias in Long QT Syndrome Type 3.	RYR2 SCN5A	1.37e-05	2	129	2	26289036
Pubmed	STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells.	STAG1 STAG2	1.37e-05	2	129	2	34648034
Pubmed	Rapid purification and characterization of histatins (histidine-rich polypeptides) from human whole saliva.	HTN1 HTN3	1.37e-05	2	129	2	2372245
Pubmed	Differential developmental deficits in retinal function in the absence of either protein tyrosine sulfotransferase-1 or -2.	TPST2 TPST1	1.37e-05	2	129	2	22745813
Pubmed	Expression and physiological function of CYP4F subfamily in human eosinophils.	CYP4F3 CYP4F12	1.37e-05	2	129	2	17980168
Pubmed	Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells.	HTN1 HTN3	1.37e-05	2	129	2	32225006
Pubmed	Histatins, a family of salivary histidine-rich proteins, are encoded by at least two loci (HIS1 and HIS2).	HTN1 HTN3	1.37e-05	2	129	2	2719677
Pubmed	Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay.	HTN1 HTN3	1.37e-05	2	129	2	18650243
Pubmed	Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer.	STAG1 STAG2	1.37e-05	2	129	2	29649003
Pubmed	Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.	HTN1 HTN3	1.37e-05	2	129	2	3286634
Pubmed	Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment.	TPST2 TPST1	1.37e-05	2	129	2	16859706
Pubmed	Cohesin subunits, STAG1 and STAG2, and cohesin regulatory factor, PDS5b, in oral squamous cells carcinomas.	STAG1 STAG2	1.37e-05	2	129	2	27341316
Pubmed	Genetic analysis in post-mortem samples with micro-ischemic alterations.	RYR2 SCN5A	1.37e-05	2	129	2	28086167
Pubmed	Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.	STAG1 STAG2	1.37e-05	2	129	2	28691904
Pubmed	Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.	PDE4B PDE4D	1.37e-05	2	129	2	15003452
Pubmed	Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1.	TPST2 TPST1	1.37e-05	2	129	2	28821720
Pubmed	Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.	STAG1 STAG2	1.37e-05	2	129	2	22415365
Pubmed	PDE4D plays a critical role in the control of airway smooth muscle contraction.	PDE4B PDE4D	1.37e-05	2	129	2	14519662
Pubmed	Nucleotide sequence analysis of the human salivary protein genes HIS1 and HIS2, and evolution of the STATH/HIS gene family.	HTN1 HTN3	1.37e-05	2	129	2	8336540
Pubmed	Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans.	TPST2 TPST1	1.37e-05	2	129	2	9733778
Pubmed	Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).	PDE4B PDE4D	1.37e-05	2	129	2	17700644
Pubmed	Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.	CYP4F3 CYP4F11	1.37e-05	2	129	2	15364545
Pubmed	Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells.	STAG1 STAG2	1.37e-05	2	129	2	19822671
Pubmed	PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.	PDE4B PDE4D	1.37e-05	2	129	2	17088426
Pubmed	Effects of ablation of N- and R-type Ca(2+) channels on pain transmission.	CACNA1B CACNA1E	1.37e-05	2	129	2	12074836
Pubmed	Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency.	TPST2 TPST1	1.37e-05	2	129	2	18243191
Pubmed	STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.	STAG1 STAG2	1.37e-05	2	129	2	32467316
Pubmed	Specialized functions of cohesins STAG1 and STAG2 in 3D genome architecture.	STAG1 STAG2	1.37e-05	2	129	2	32294612
Pubmed	Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation.	STAG1 STAG2	1.37e-05	2	129	2	31495782
Pubmed	Fyn Regulates Binding Partners of Cyclic-AMP Dependent Protein Kinase A.	SLC25A12 CCT5 AKAP13 PRKDC PCNT	1.41e-05	82	129	5	30274258
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1E TRAF3 PDE4B WDR7 HUWE1 TEX10 DCTN1 AGO1 KIAA1217 MFN2 BAIAP2 PRRC2B MTSS2 PCNT	1.45e-05	963	129	14	28671696
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	GAPVD1 PARD3B VPS13D MTUS1 KIAA1217 COBL AKAP13 BAIAP2 TRAPPC14 PLEKHA7 PLK4 MTSS2 VCPIP1	2.01e-05	861	129	13	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WDR7 SNX19 EPG5 MFN2 COBL ULK2 PRRC2B PCNT VCPIP1	2.24e-05	407	129	9	12693553
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CACNA1E STAG1 STRBP MRPL53 CCDC50 REL EPX TEX10 DCTN1 RYR2 CCDC27 SLC25A12 PRKDC RIMS2 STAG2 PRRC2B PCNT	2.53e-05	1442	129	17	35575683
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TSHZ3 GAPVD1 USP24 HUWE1 DCTN1 GPRASP2 PCNT VCPIP1 NPAT	2.76e-05	418	129	9	34709266
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	GAPVD1 PDE4D LRSAM1 USP24 UBA2 ISOC1 MCM2 HUWE1 TUBG1 BLMH APPL2 CCT5 ASL PLA2G4A PLCG1 PRKDC VCPIP1	2.83e-05	1455	129	17	22863883
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	LEMD3 DAG1 MCM2 PARD3B APPL2 KIAA1217 COBL PLEKHA7 MTSS2	2.92e-05	421	129	9	36976175
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	USP30 LEMD3 MRPL53 SYBU HUWE1 SNX19 POLR3A VPS13D SLC25A12 CCT5 NOM1 KIAA1217 TOX3 MFN2 PRRC2B PCNT VCPIP1	4.01e-05	1496	129	17	32877691
Pubmed	Characterization of the interaction between the cohesin subunits Rad21 and SA1/2.	STAG1 STAG2	4.09e-05	3	129	2	23874961
Pubmed	Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.	PDE4D RYR2	4.09e-05	3	129	2	16213210
Pubmed	The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).	PDE4B PDE4D	4.09e-05	3	129	2	24555506
Pubmed	The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.	CACNA1B CACNA1E	4.09e-05	3	129	2	38996073
Pubmed	IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions.	BAIAP2 MTSS2	4.09e-05	3	129	2	18215522
Pubmed	[Novel MFN2, BSCL2 and LRSAM1 variants in a cohort of Chinese patients with Charcot-Marie-Tooth disease].	LRSAM1 MFN2	4.09e-05	3	129	2	35922214
Pubmed	Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis.	HUWE1 MFN2	4.09e-05	3	129	2	22748923
Pubmed	CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion.	CPEB3 CPEB4	4.09e-05	3	129	2	20937770
Pubmed	Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.	PDE4B PDE4D	4.09e-05	3	129	2	17404263
Pubmed	Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.	PDE4B PDE4D	4.09e-05	3	129	2	16034090
Pubmed	Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease.	VPS13D MFN2	4.09e-05	3	129	2	34019822
Pubmed	Enhanced expression, native purification, and characterization of CCR5, a principal HIV-1 coreceptor.	TPST2 TPST1	4.09e-05	3	129	2	10497246
Pubmed	Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma.	HTN1 HTN3	4.09e-05	3	129	2	35489730
Pubmed	Protein expression profiles in murine ventricles modeling catecholaminergic polymorphic ventricular tachycardia: effects of genotype and sex.	RYR2 SCN5A	4.09e-05	3	129	2	32713021
Pubmed	Single-molecule imaging reveals a direct role of CTCF's zinc fingers in SA interaction and cluster-dependent RNA recruitment.	STAG1 STAG2	4.09e-05	3	129	2	38742641
Pubmed	Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications.	STAG1 STAG2	4.09e-05	3	129	2	24335498
Pubmed	Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis.	PARD3B PLA2G4A	4.09e-05	3	129	2	18471798
Pubmed	CPEB2, a novel putative translational regulator in mouse haploid germ cells.	CPEB3 CPEB4	4.09e-05	3	129	2	12672660
Pubmed	CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA.	CPEB3 CPEB4	4.09e-05	3	129	2	17024188
Pubmed	Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.	PDE4B PDE4D	4.09e-05	3	129	2	15585880
Pubmed	Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.	PDE4B PDE4D	4.09e-05	3	129	2	10213096
Pubmed	Protein kinase C delta (PKCdelta) interacts with microtubule organizing center (MTOC)-associated proteins and participates in meiotic spindle organization.	TUBG1 PCNT	4.09e-05	3	129	2	18602096
Interaction	NINL interactions	LRSAM1 HUWE1 DCTN1 TUBG1 DNAH1 MTUS1 KIAA1217 CEP250 COBL PRKDC PLEKHA7 PRRC2B PCNT VCPIP1	9.89e-07	458	125	14	int:NINL
Interaction	YWHAH interactions	GAPVD1 RHBDF2 ISOC1 MCM2 PARD3B HUWE1 DCTN1 TUBG1 VPS13D MTUS1 KIAA1217 SHCBP1 COBL AKAP13 BAIAP2 TRAPPC14 RIMS2 PLEKHA7 PLK4 MTSS2 PCNT VCPIP1	1.06e-06	1102	125	22	int:YWHAH
Cytoband	9q21.32	SPATA31D4 SPATA31D1 SPATA31D3	2.03e-05	19	129	3	9q21.32
Cytoband	9q33.3	GAPVD1 STRBP LRSAM1	1.57e-04	37	129	3	9q33.3
GeneFamily	Phosphodiesterases	PDE4B PDE4D PDE8A PDE9A	4.50e-06	24	85	4	681
GeneFamily	Histatins and statherin	HTN1 HTN3	6.53e-05	3	85	2	971
GeneFamily	I-BAR domain containing	BAIAP2 MTSS2	2.16e-04	5	85	2	1287
GeneFamily	Cohesin complex	STAG1 STAG2	6.00e-04	8	85	2	1060
GeneFamily	Cytochrome P450 family 4	CYP4F3 CYP4F12 CYP4F11	6.40e-04	36	85	3	1003
GeneFamily	Sulfotransferases, membrane bound	CHST5 TPST2 TPST1	6.94e-04	37	85	3	763
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4B APPL2 AKAP13 PLCG1 PLEKHA7	2.87e-03	206	85	5	682
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLA2G4A PLCG1	3.55e-03	19	85	2	832
GeneFamily	EF-hand domain containing	CACNA1B CACNA1E RYR2 SLC25A12 PLCG1	3.73e-03	219	85	5	863
CoexpressionAtlas	ratio_StemCell_vs_induced-Ectoderm_top-relative-expression-ranked_1000_k-means-cluster#2	TSHZ3 RYR2 ZFYVE28 FAM20C SCN5A MYO18B MX1	1.94e-05	140	125	7	ratio_SC_vs_ECTO_1000_K2
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D PDE9A STAG1 CPEB3 PARD3B KCNJ3 KIAA1217 PLEKHA7	7.77e-08	189	128	8	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 PDE4D DPY19L2 FAM20C KCNJ3 SHCBP1 TOX3 VWA5B1	7.77e-08	189	128	8	532aaf02b364c5c4f58a2021c7c21d86df3875c9
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HYAL4 PDE4D MYO5C CT62 MTUS1 KIAA1217 TOX3	5.33e-07	166	128	7	c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5C PLEKHG4B MTUS1 KIAA1217 COBL BAIAP2 PLEKHA7	1.06e-06	184	128	7	42ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	PDE4D MYO5C PLEKHG4B MTUS1 KIAA1217 TOX3 PLEKHA7	1.10e-06	185	128	7	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	CACNA1E DPY19L2 RYR2 KCNJ3 CPEB4 SCN5A MYO18B	1.23e-06	188	128	7	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	PDE4D DPY19L2 RYR2 KIAA1217 CPEB4 AKAP13 MYO18B	1.27e-06	189	128	7	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	CACNA1E DPY19L2 RYR2 KCNJ3 CPEB4 SCN5A MYO18B	1.36e-06	191	128	7	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 PDE4D DPY19L2 PDE9A KCNJ3 SHCBP1 TOX3	1.36e-06	191	128	7	96b78b4e819ea6052334bfcbc7abbf35897df885
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D DPY19L2 AVPR2 MTUS1 KCNJ3 SHCBP1 TOX3	1.41e-06	192	128	7	40f44ac4ab673ee6156abdd2074a60b9de3281ad
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	PDE4D PARD3B MYO5C MTUS1 KIAA1217 COBL PLEKHA7	1.41e-06	192	128	7	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	DPY19L2 RYR2 CPEB4 SCN5A COBL AKAP13 MYO18B	1.57e-06	195	128	7	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5C PLEKHG4B MTUS1 AKAP13 BAIAP2 PLEKHA7	1.84e-06	127	128	6	5b0adbcafad31a6759c9bdce2f7f9591a8edc450
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 PDE4D DPY19L2 SHCBP1 TOX3 VWA5B1	6.04e-06	156	128	6	a4b0e89255ea5d60198cb2b3e739981f9c9cf5c5
ToppCell	droplet-Fat-Bat-18m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAG1 MANEA APPL2 MTUS1 NOM1 PLCG1	1.16e-05	175	128	6	b4f01e7782cdd107d0817ef601891fd3a382bc35
ToppCell	droplet-Fat-Bat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAG1 MANEA APPL2 MTUS1 NOM1 PLCG1	1.16e-05	175	128	6	ef6f811d8e1839f405c3b41090ddf79be57a099f
ToppCell	droplet-Fat-Bat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAG1 MANEA APPL2 MTUS1 NOM1 PLCG1	1.16e-05	175	128	6	7f7598d46d10bff1cbea42f950bdde1aaa16e9a4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 PDE4D KCNJ3 SHCBP1 TOX3 VWA5B1	1.24e-05	177	128	6	f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCell	myeloid-Dendritic_cell-Plasmacytoid_dendritic_cell\|myeloid / Lineage, cell class and subclass	HYAL4 STRBP CCDC50 ARL5C COBL MMP15	1.28e-05	178	128	6	f75591988bbbeba073b66329a3437cb9b02f7648
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|356C / Donor, Lineage, Cell class and subclass (all cells)	USP30 TRAF3 MCF2L2 PLCG1 MTSS2 VCPIP1	1.28e-05	178	128	6	8b939659f713eea50a1a6e28b571f680ca0b4c12
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE9A FAM20C MTUS1 CNTN5 SCN5A TOX3	1.32e-05	179	128	6	3b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D DPY19L2 KCNJ3 SHCBP1 TOX3 MYO18B	1.50e-05	183	128	6	b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	USP30 TRAF3 MCF2L2 NDFIP2 MTSS2 VCPIP1	1.59e-05	185	128	6	e06a784a297f357f3f8e761c24fa70722048ab42
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPX RYR2 KCNJ3 SCN5A MYO18B PLEKHA7	1.64e-05	186	128	6	337f768cc43db2db96ba6495b076006b1a5b0331
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 PDE4D DPY19L2 KCNJ3 SHCBP1 TOX3	1.64e-05	186	128	6	08632045d499e61dd96ff29a5a9a208afe58dc58
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPX RYR2 KCNJ3 SCN5A MYO18B PLEKHA7	1.64e-05	186	128	6	e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5C PLEKHG4B MTUS1 COBL BAIAP2 PLEKHA7	1.69e-05	187	128	6	58d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D DPY19L2 KCNJ3 SHCBP1 TOX3 VWA5B1	1.69e-05	187	128	6	2d17408b3b5f09d135084fd7ccce98e6b5ca632b
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	PDE4D MYO5C MTUS1 KIAA1217 COBL PLEKHA7	1.75e-05	188	128	6	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 PDE4D DPY19L2 SHCBP1 TOX3 VWA5B1	1.75e-05	188	128	6	58ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	DPY19L2 SESN1 RYR2 CPEB4 SCN5A MYO18B	1.80e-05	189	128	6	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 PDE4D DPY19L2 SHCBP1 TOX3 VWA5B1	1.80e-05	189	128	6	a9864873b19ab3e60acf11f288fa7275badc2e42
ToppCell	PBMC-Mild-cDC_12\|Mild / Compartment, Disease Groups and Clusters	DPY19L2 MCM2 SPON1 SHCBP1 PRKDC PLK4	1.80e-05	189	128	6	946c95d2ecc36b241f58e8c4ad6455fe47c762fa
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 PDE4D AVPR2 KCNJ3 SHCBP1 TOX3	1.85e-05	190	128	6	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	COVID-19-Epithelial_cells-Airway_goblet\|COVID-19 / group, cell type (main and fine annotations)	MYO5C PLEKHG4B MTUS1 KIAA1217 TOX3 PLEKHA7	1.85e-05	190	128	6	51ca9ef4df3220487152fcf684147730637c7cc1
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	DPY19L2 RYR2 CPEB4 SCN5A AKAP13 MYO18B	1.85e-05	190	128	6	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D PDE8A STAG1 PARD3B AKAP13 PLEKHA7	1.97e-05	192	128	6	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PDE4D PDE8A STAG1 MCF2L2 AKAP13 PLEKHA7	2.03e-05	193	128	6	779276e775cb2492e8dd36436295a536084a6415
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D AGXT2 CPEB4 TOX3 COBL PLEKHA7	2.03e-05	193	128	6	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D AVPR2 MTUS1 KCNJ3 SHCBP1 TOX3	2.09e-05	194	128	6	4d6c9b016e3a0641954a8ea10c97d1cd76fadd9f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D KCNJ3 CPEB4 TOX3 COBL PLEKHA7	2.09e-05	194	128	6	5eaaa81f4b2535f983c424aaef00077089526a5c
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	DPY19L2 RYR2 KCNJ3 CPEB4 SCN5A MYO18B	2.09e-05	194	128	6	c3535f7cc0076653c72db582047cff053c322397
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	DPY19L2 RYR2 CPEB4 SCN5A COBL MYO18B	2.15e-05	195	128	6	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	STRBP PARD3B KCNJ3 CPEB4 COBL PLEKHA7	2.21e-05	196	128	6	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE9A PARD3B KCNJ3 CPEB4 COBL PLEKHA7	2.21e-05	196	128	6	eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	MYO5C LIPE MTUS1 PLA2G4A BAIAP2 MMP15	2.27e-05	197	128	6	1a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B STRBP SYBU RYR2 KCNJ3 RIMS2	2.34e-05	198	128	6	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1B STRBP RYR2 KCNJ3 CNTN5 RIMS2	2.34e-05	198	128	6	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Bronchial-NucSeq-Immune_Lymphocytic-B-B_plasma\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRAF3 PDE4B WDR64 MANEA LRRK1 CPEB4	2.34e-05	198	128	6	567fcf882c8612356946240843525b786f3c8dbe
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STRBP MYO5C MTUS1 KIAA1217 COBL PLEKHA7	2.41e-05	199	128	6	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	STRBP MYO5C KIAA1217 TOX3 COBL PLEKHA7	2.47e-05	200	128	6	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MYO5C KIAA1217 CPEB4 TOX3 COBL PLEKHA7	2.47e-05	200	128	6	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B MCM2 KCNJ3 NOM1 KIAA1217	6.04e-05	144	128	5	1b9e95e4f6e40042d3cf2f94c067f3a6b19428ea
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D MTUS1 KCNJ3 SHCBP1 TOX3	6.66e-05	147	128	5	64fa0753a3a79f492ef8acc6942bf90d379a983f
ToppCell	Lymphoid-Lymphoid-B_cells\|Lymphoid / shred on cell class and cell subclass (v4)	STRBP DAG1 CCDC50 REL ARL5C	7.33e-05	150	128	5	5ebf6b4b9b029422a4676ba09a6a9225bd25db47
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D DPY19L2 PCNX4 TOX3 VWA5B1	7.33e-05	150	128	5	87968ce885a4959616f0321f58517fe8029ba1b1
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPST1 PDE4D PLEKHG4B SHCBP1 TOX3	7.56e-05	151	128	5	10da94037225a71844281ddcb395072250a78094
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MRPL53 NDFIP2 POMGNT2 TRAPPC14 PCNT	9.65e-05	159	128	5	7c2f70a7cba880115ccd676fb6c5f18488a5b74f
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B WDR64 MROH2A RYR2 ARL5C	9.94e-05	160	128	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B WDR64 MROH2A RYR2 ARL5C	9.94e-05	160	128	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	PDE8A USP24 AGO1 MFN2 AKAP13	1.05e-04	162	128	5	810881210e015c788814e4fe8d7a24c929cf2621
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDE4B CCDC50 LRRK1 ARL5C GABRR3	1.05e-04	162	128	5	86a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP30 STAG1 USP24 CCDC50 AGXT2	1.12e-04	164	128	5	b895674ed2df87db8fbfb30b7e31620945588491
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_prolif\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LEMD3 FAM20C SPON1 MFN2 PCNT	1.32e-04	170	128	5	b1a16600754e0c12f7d39c9221f1b03135833f16
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E MROH2A AGXT2 FAM20C CYP4F3	1.36e-04	171	128	5	f5014e3c387fe3118944af392abe10d6b9b0abab
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KIAA1217 SCN5A MYO18B TRAPPC14	1.38e-04	91	128	4	b0658e020f80e56fab9d2aa07e321d9b33d7af2c
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE9A FAM20C CNTN5 SCN5A TOX3	1.43e-04	173	128	5	61907116a1460bc157ba73b5edd108db7dd5de4b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 DPY19L2 PCNX4 TOX3 VWA5B1	1.43e-04	173	128	5	0bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E AGXT2 FAM20C CYP4F3 BAIAP2	1.43e-04	173	128	5	8888434641ea554a9b62c436e87920378eef29cd
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1E CHST5 CYP4F3 CYP4F12 RIMS2	1.47e-04	174	128	5	3503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell	Healthy/Control-Plasmablast\|Healthy/Control / Disease group and Cell class	NDFIP2 MCM2 MANEA SHCBP1 PLEKHA7	1.47e-04	174	128	5	97d19ef3240a1f648c6befaabb9ce45ad469cbce
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1B CACNA1E SYBU RIMS2 VWA5B1	1.51e-04	175	128	5	8362a46f5804333baa84cd56d450bc147f372a7e
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CACNA1B CACNA1E SYBU RIMS2 VWA5B1	1.51e-04	175	128	5	8b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE9A FAM20C MTUS1 SCN5A TOX3	1.55e-04	176	128	5	95d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MTUS1 SPON1 KIAA1217 COBL AKAP13	1.59e-04	177	128	5	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HYAL4 DPY19L2 PCNX4 TOX3 VWA5B1	1.59e-04	177	128	5	8e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5C MTUS1 PLA2G4A BAIAP2 PLEKHA7	1.68e-04	179	128	5	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK1 POLR3A FAM20C MX1 INKA1	1.72e-04	180	128	5	be10fe5bf7c3a671c42704ce7dd8226ab6896794
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRK1 POLR3A FAM20C MX1 INKA1	1.72e-04	180	128	5	3b747a517ce75ef2ff09011c037dad7b01ed3e03
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPST2 DPY19L2 USP24 CPEB4 TOX3	1.77e-04	181	128	5	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell	Healthy/Control-pDC\|World / Disease group and Cell class	WDR64 CCDC50 ARL5C PLEKHG4B MMP15	1.81e-04	182	128	5	97e0eee10905f2cf2bebb09e474629fc224f4397
ToppCell	Healthy_donor-MAIT\|Healthy_donor / disease group, cell group and cell class (v2)	PDE4B PDE4D DPY19L2 SESN1 KIAA1217	1.81e-04	182	128	5	ac7c83464487ecde3df6804a99551307bd768f21
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D DPY19L2 KCNJ3 SHCBP1 TOX3	1.81e-04	182	128	5	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D DPY19L2 KCNJ3 SHCBP1 TOX3	1.86e-04	183	128	5	d340ab5a77e8d819a1dfb4ca3e9a4b9bc988923c
ToppCell	COVID-19-B_cells\|COVID-19 / group, cell type (main and fine annotations)	STRBP MANEA LRRK1 SHCBP1 CPEB4	1.86e-04	183	128	5	2c016bb59f131a0e821853b085289a3583f0a729
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1E TPST1 A3GALT2 CPEB3 SPON1	1.91e-04	184	128	5	42cadfdb5d29a50bd7e901ddd14d42b39e8474f0
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	DPY19L2 RYR2 CPEB4 AKAP13 MYO18B	1.91e-04	184	128	5	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PDE4D MYO5C MTUS1 KIAA1217 TOX3	1.96e-04	185	128	5	98b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCell	15-Trachea-Epithelial-Multiciliated_precursor\|Trachea / Age, Tissue, Lineage and Cell class	DPY19L2 STRBP TUBG1 MYO5C PLK4	1.96e-04	185	128	5	9a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE4D STRBP RYR2 KCNJ3 RIMS2	1.96e-04	185	128	5	cdd75abdaa1ecedfd2e636203b83a6ac1782f0c3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE4D PLEKHG4B SHCBP1 TOX3 MYO18B	1.96e-04	185	128	5	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	droplet-Marrow-nan-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WAS CCDC50 REL ARL5C STAG2	1.96e-04	185	128	5	7adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCell	IIF-Lymphocyte-B-B_naive\|IIF / Disease, Lineage and Cell Type	PDE4B STRBP REL SESN1 SPON1	1.96e-04	185	128	5	dec48908addfc71f32f5ce0ce73f2926e476f60b
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PDE4D STRBP MYO5C MTUS1 KIAA1217	2.01e-04	186	128	5	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5C PLEKHG4B MTUS1 COBL PLEKHA7	2.01e-04	186	128	5	4e94158db52df41d71e67b02b9895a358eebee0f
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5C PLEKHG4B COBL BAIAP2 PLEKHA7	2.01e-04	186	128	5	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	IPF-Lymphoid-B_Plasma\|Lymphoid / Disease state, Lineage and Cell class	MANEA LRRK1 SHCBP1 CPEB4 PLK4	2.01e-04	186	128	5	f9c21daf905d0bb0e0e769ca4bb069ea4b1ba25b
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CACNA1E AGXT2 FAM20C CYP4F3 PLEKHA7	2.01e-04	186	128	5	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	STAG1 PARD3B REL VPS13D NPAT	2.01e-04	186	128	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5C MTUS1 PLA2G4A BAIAP2 PLEKHA7	2.01e-04	186	128	5	e83718fabb057100835d3357df407f283d23fe16
Drug	felodipine	CACNA1B CACNA1E PDE4B PDE4D PDE8A PDE9A RYR2 CYP4F3 CYP4F12 CYP4F11	4.15e-08	169	128	10	CID000003333
Drug	CI-930	PDE4B PDE4D PDE8A PDE9A	4.31e-06	20	128	4	CID003021728
Drug	9-beta-D-arabinofuranosylguanine	CACNA1B CACNA1E PDE4B PDE4D WAS PDE8A PDE9A DAG1 REL TUBG1 BLMH APPL2 KCNJ3 MFN2 PLCG1 BAIAP2 MX1	5.15e-06	843	128	17	CID000000765
Drug	AA-2379	PDE4B PDE4D PDE8A PDE9A	5.30e-06	21	128	4	CID000128390
Drug	HWA 153	PDE4B PDE4D PDE8A PDE9A	6.45e-06	22	128	4	CID000162797
Drug	papaverine	CACNA1B CACNA1E PDE4B PDE4D PDE8A PDE9A RYR2 PLCG1	7.06e-06	176	128	8	CID000004680
Drug	griseolic acid	PDE4B PDE4D PDE8A PDE9A	7.77e-06	23	128	4	CID000127607
Drug	atherosperminine	PDE4B PDE4D PDE8A PDE9A	7.77e-06	23	128	4	CID000096918
Drug	desethyl KBT-3022	PDE4B PDE4D PDE8A PDE9A	1.29e-05	26	128	4	CID000127736
Drug	T-440	PDE4B PDE4D PDE8A PDE9A	1.29e-05	26	128	4	CID000177965
Drug	Ro 15-2041	PDE4B PDE4D PDE8A PDE9A	1.29e-05	26	128	4	CID000132434
Drug	Sulfadiazine [68-35-9]; Down 200; 16uM; MCF7; HT_HG-U133A	RYR2 VPS13D PCNX4 KCNJ3 CEP250 AKAP13 PLCG1 PRRC2B	1.55e-05	196	128	8	5523_DN
Drug	Ketoprofen [22071-15-4]; Up 200; 15.8uM; PC3; HT_HG-U133A	PDE4D LRRK1 HUWE1 STK16 MTUS1 SCN5A PLCG1 RIMS2	1.55e-05	196	128	8	3729_UP
Drug	Streptomycin sulfate [3810-74-0]; Up 200; 2.8uM; MCF7; HT_HG-U133A	PDE4D DAG1 ABCA7 RYR2 SPON1 CEP250 TOX3 PLK4	1.61e-05	197	128	8	3195_UP
Drug	Midecamycin [35457-80-8]; Down 200; 5uM; PC3; HG-U133A	VPS13D MFN2 PRKDC ULK2 PLK4 STAG2 PRRC2B MX1	1.67e-05	198	128	8	1943_DN
Drug	Tubocurarine chloride pentahydrate (+) [6989-98-6]; Down 200; 5.2uM; HL60; HG-U133A	TRAF3 USP24 VPS13D SLC50A1 PCNX4 PLA2G4A AKAP13 PLK4	1.73e-05	199	128	8	1738_DN
Drug	NVP ABE171	PDE4B PDE4D EPX	2.02e-05	10	128	3	ctd:C451724
Drug	Tussiglaucin	PDE4B PDE4D EPX	2.02e-05	10	128	3	CID000010145
Drug	imidazole-4-carboxamide	PDE4B PDE4D PDE8A PDE9A	3.03e-05	32	128	4	CID000152917
Drug	V11294 Analogue 5f	PDE4B PDE4D	3.14e-05	2	128	2	CID011214587
Drug	V11294 Analogue 5t	PDE4B PDE4D	3.14e-05	2	128	2	CID011226695
Drug	V11294 Analogue 5e	PDE4B PDE4D	3.14e-05	2	128	2	CID011443441
Drug	V11294 Analogue 5n	PDE4B PDE4D	3.14e-05	2	128	2	CID011238279
Drug	aristolactam AII	CACNA1B CACNA1E	3.14e-05	2	128	2	CID000148657
Drug	alkosin	CACNA1B CACNA1E	3.14e-05	2	128	2	CID005488638
Drug	V11294 Analogue 5p	PDE4B PDE4D	3.14e-05	2	128	2	CID011478659
Drug	V11294 Analogue 5o	PDE4B PDE4D	3.14e-05	2	128	2	CID011249748
Drug	V11294 Analogue 5c	PDE4B PDE4D	3.14e-05	2	128	2	CID011179896
Drug	V11294 Analogue 5b	PDE4B PDE4D	3.14e-05	2	128	2	CID011443760
Drug	Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid	PDE4B PDE4D	3.14e-05	2	128	2	DB03849
Drug	T-2585.HCl	PDE4B PDE4D	3.14e-05	2	128	2	CID006918355
Drug	V11294 Analogue 5m	PDE4B PDE4D	3.14e-05	2	128	2	CID011477773
Drug	V11294 Analogue 8a	PDE4B PDE4D	3.14e-05	2	128	2	CID011442865
Drug	V11294 Analogue 5q	PDE4B PDE4D	3.14e-05	2	128	2	CID011318772
Drug	V11294 Analogue 5h	PDE4B PDE4D	3.14e-05	2	128	2	CID011306698
Drug	3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester	PDE4B PDE4D	3.14e-05	2	128	2	DB01959
Drug	4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone	PDE4B PDE4D	3.14e-05	2	128	2	DB01954
Drug	M 98	PDE4B PDE4D	3.14e-05	2	128	2	CID006420180
Drug	V11294 Analogue 5i	PDE4B PDE4D	3.14e-05	2	128	2	CID011376249
Drug	norcepharadione B	CACNA1B CACNA1E	3.14e-05	2	128	2	CID000189168
Drug	V11294 Analogue 5d	PDE4B PDE4D	3.14e-05	2	128	2	CID011283750
Drug	3-cyclopentyloxy-4-methoxybenzoic acid	PDE4B PDE4D	3.14e-05	2	128	2	CID002779323
Drug	V11294 Analogue 5v	PDE4B PDE4D	3.14e-05	2	128	2	CID011375325
Drug	3-cyclopentyloxy-4-methoxybenzaldehyde	PDE4B PDE4D	3.14e-05	2	128	2	CID002735893
Drug	Np-V	PDE4B PDE4D	3.14e-05	2	128	2	CID009999276
Drug	piperolactam A	CACNA1B CACNA1E	3.14e-05	2	128	2	CID003081016
Drug	(S)-Rolipram	PDE4B PDE4D	3.14e-05	2	128	2	DB03606
Drug	1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester	PDE4B PDE4D	3.14e-05	2	128	2	ctd:C554440
Drug	V11294 Analogue 5r	PDE4B PDE4D	3.14e-05	2	128	2	CID011168555
Drug	V11294 Analogue 5j	PDE4B PDE4D	3.14e-05	2	128	2	CID011433797
Drug	V11294 Analogue 5a	PDE4B PDE4D	3.14e-05	2	128	2	CID011386897
Drug	V11294 Analogue 5k	PDE4B PDE4D	3.14e-05	2	128	2	CID011456440
Drug	(R)-Rolipram	PDE4B PDE4D	3.14e-05	2	128	2	DB04149
Drug	dyphylline	PDE4B PDE4D PDE8A PDE9A	3.44e-05	33	128	4	CID000003182
Drug	scalaradial	PDE4B PDE4D REL PLA2G4A	3.44e-05	33	128	4	CID000119491
Drug	PD-V	STAG1 ASL STAG2	3.68e-05	12	128	3	CID000444615
Drug	AH 21-132	PDE4B PDE4D PDE8A PDE9A	5.45e-05	37	128	4	CID003035793
Drug	1, 3-diallylurea	CACNA1E DAG1 HUWE1 PLK4 MX1	6.13e-05	74	128	5	CID000074537
Drug	halothane	CACNA1B CACNA1E RYR2 LIPE KCNJ3 CYP4F3 CYP4F12 PLCG1 CYP4F11	7.30e-05	314	128	9	CID000003562
Drug	6-trans-leukotriene B4	PDE4B PDE4D EPX PLA2G4A CYP4F3 CYP4F12 PLCG1 CYP4F11	7.99e-05	247	128	8	CID000000169
Drug	caffeine	CACNA1B CACNA1E PDE4B PDE4D PDE8A PDE9A RYR2 LIPE CYP4F3 CYP4F12 PLCG1 CYP4F11	8.03e-05	562	128	12	CID000002519
Drug	CDP840	PDE4B PDE4D EPX	9.21e-05	16	128	3	CID000127928
Drug	Bleomycin acid	REL BLMH	9.37e-05	3	128	2	CID000002410
Drug	BW A78U	PDE4B PDE4D	9.37e-05	3	128	2	CID000127779
Drug	4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid	PDE4B PDE4D	9.37e-05	3	128	2	DB08299
Drug	Org 4428	PDE4B PDE4D	9.37e-05	3	128	2	CID000166560
Drug	1-Pyrrolidinebutanenitrile	PDE4B PDE4D	9.37e-05	3	128	2	CID000118838
Drug	Triflupromazine hydrochloride [1098-60-8]; Down 200; 10.2uM; MCF7; HT_HG-U133A	TRAF3 WAS RHBDF2 DAG1 VPS13D SLC25A12 BAIAP2	1.09e-04	192	128	7	7466_DN
Drug	8 mm x	PDE4B PDE4D REL	1.11e-04	17	128	3	CID000155806
Drug	Org 9935	PDE4B PDE4D EPX	1.11e-04	17	128	3	CID000131100
Drug	(+,-)-Synephrine [94-07-5]; Up 200; 24uM; MCF7; HT_HG-U133A	PDE4D PDE9A CPEB3 KCNJ3 CNTN5 CYP4F11 RPA4	1.12e-04	193	128	7	3578_UP
Drug	Dioxybenzone [131-53-3]; Up 200; 16.4uM; MCF7; HT_HG-U133A	HYAL4 CHST5 PDE4D NDP CEP250 RIMS2 CYP4F11	1.16e-04	194	128	7	5699_UP
Drug	Fusaric acid [536-69-6]; Up 200; 22.4uM; HL60; HT_HG-U133A	VPS13D MTUS1 CEP250 PLCG1 TRAPPC14 PLK4 MX1	1.16e-04	194	128	7	1308_UP
Drug	diosmetin	UGT1A4 BLMH CYP4F3 CYP4F12 CYP4F11	1.19e-04	85	128	5	CID005281612
Drug	valinomycin; Down 200; 0.1uM; PC3; HT_HG-U133A	MANEA NDP MTUS1 MFN2 COBL TRAPPC14 RPA4	1.20e-04	195	128	7	5911_DN
Drug	cilostazol	PDE4B PDE4D PDE8A PDE9A SCN5A	1.26e-04	86	128	5	CID000002754
Drug	Minaprine dihydrochloride [25953-17-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	DCTN1 STK16 MFN2 PLCG1 BAIAP2 TRAPPC14 MMP15	1.28e-04	197	128	7	4814_DN
Drug	Tiabendazole [148-79-8]; Up 200; 19.8uM; HL60; HT_HG-U133A	CHST5 LRRK1 HUWE1 SPON1 TRAPPC14 RIMS2 GPRIN2	1.32e-04	198	128	7	2479_UP
Drug	Trapidil [15421-84-8]; Up 200; 19.4uM; MCF7; HT_HG-U133A	WAS RYR2 VPS13D CNTN5 COBL GPRIN2 VCPIP1	1.32e-04	198	128	7	7475_UP
Drug	nordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A_EA	TPST2 TRAF3 USP24 DCTN1 AGO1 PCNX4 SHCBP1	1.32e-04	198	128	7	1061_DN
Drug	Cinnarizine [298-57-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	TPST2 SNX19 MTUS1 COBL TRAPPC14 MMP15 PRRC2B	1.32e-04	198	128	7	7174_DN
Drug	Cilomilast	PDE4B PDE4D EPX	1.33e-04	18	128	3	ctd:C433247
Drug	Methacholine chloride [62-51-1]; Down 200; 20.4uM; PC3; HT_HG-U133A	WAS RYR2 STK16 MTUS1 COBL AKAP13 ULK2	1.36e-04	199	128	7	5773_DN
Drug	Reserpine [50-55-5]; Down 200; 6.6uM; MCF7; HT_HG-U133A	USP24 VPS13D KCNJ3 CEP250 CYP4F12 BAIAP2 NPAT	1.36e-04	199	128	7	3341_DN
Drug	Benoxinate hydrochloride [5987-82-6]; Up 200; 11.6uM; MCF7; HT_HG-U133A	PDE4D WAS ABCA7 CYP4F12 PLCG1 MX1 GPRIN2	1.36e-04	199	128	7	4115_UP
Drug	(cis-) Nanophine [5072-45-7]; Down 200; 26.8uM; PC3; HT_HG-U133A	TPST2 NDP LRRK1 ABCA7 BAIAP2 TRAPPC14 ULK2	1.36e-04	199	128	7	4543_DN
Drug	Chlorthalidone [77-36-1]; Up 200; 11.8uM; PC3; HT_HG-U133A	WAS MANEA SESN1 BAIAP2 TRAPPC14 PLK4 VCPIP1	1.40e-04	200	128	7	7152_UP
Drug	AC1Q646P	PDE4B PDE4D PDE8A PDE9A	1.41e-04	47	128	4	CID000005673
Drug	Piclamilast	PDE4B PDE4D	1.87e-04	4	128	2	DB01791
Drug	AC 110	CACNA1B CACNA1E	1.87e-04	4	128	2	CID000022860
Drug	5-diazouracil	BLMH MX1	1.87e-04	4	128	2	CID000024327
Drug	silibinin	PDE4B PDE4D PDE8A PDE9A REL UGT1A4 AGXT2 PRKDC	2.14e-04	285	128	8	CID000005213
Drug	AC1L4NPY	STAG1 STAG2	3.10e-04	5	128	2	CID000160495
Drug	D-22888	PDE4B PDE4D	3.10e-04	5	128	2	CID000197714
Drug	almagel	CACNA1B CACNA1E	3.10e-04	5	128	2	CID003080942
Drug	Ibudilast	PDE4B PDE4D	3.10e-04	5	128	2	DB05266
Drug	Sa-6	STAG1 STAG2	3.10e-04	5	128	2	CID000056560
Drug	1,7-naphthyridine	PDE4B PDE4D	3.10e-04	5	128	2	CID000009209
Disease	Arrhythmogenic Right Ventricular Dysplasia	RYR2 SCN5A	4.74e-05	3	118	2	C0349788
Disease	familial hemiplegic migraine 1 (implicated_via_orthology)	CACNA1B CACNA1E	4.74e-05	3	118	2	DOID:0111181 (implicated_via_orthology)
Disease	migraine (implicated_via_orthology)	CACNA1B CACNA1E	9.46e-05	4	118	2	DOID:6364 (implicated_via_orthology)
Disease	protein-tyrosine sulfotransferase 1 measurement	TPST1 ASL	9.46e-05	4	118	2	EFO_0801970
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	TRAF3 PDE4B STAG1 PARD3B TEX10 SNX19 BAIAP2 MMP15	1.12e-04	364	118	8	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	body fat percentage	TRAF3 PDE4B STAG1 PARD3B TEX10 SNX19 BAIAP2 MMP15 PRRC2B	1.56e-04	488	118	9	EFO_0007800
Disease	Global developmental delay	CACNA1B CACNA1E AGO1 SLC25A12 STAG2	2.01e-04	133	118	5	C0557874
Disease	response to dolutegravir	TRAF3 UGT1A4 CNTN5	2.34e-04	30	118	3	EFO_0600017
Disease	inclusion body myositis (is_implicated_in)	DAG1 TUBG1	2.35e-04	6	118	2	DOID:3429 (is_implicated_in)
Disease	risk-taking behaviour	CACNA1E GAPVD1 PDE4B STAG1 A3GALT2 PARD3B RYR2 LHX9 KCNJ3 CPEB4 MTSS2	2.54e-04	764	118	11	EFO_0008579
Disease	hereditary ataxia (implicated_via_orthology)	CACNA1B CACNA1E	3.29e-04	7	118	2	DOID:0050951 (implicated_via_orthology)
Disease	attention deficit hyperactivity disorder, substance abuse, antisocial behaviour measurement	TSHZ3 GAPVD1 TRAF3 PDE4B RYR2 POMGNT2 KCNJ3 CPEB4 PRKDC BAIAP2 PRRC2B	3.78e-04	801	118	11	EFO_0003888, EFO_0007052, MONDO_0002491
Disease	amyloid-beta measurement	PDE4D SESN1 NOM1 KIAA1217 CNTN5 PRKDC PLEKHA7	5.79e-04	355	118	7	EFO_0005194
Disease	progression free survival, response to carboplatin, methylcobalamin deficiency type cblE, ovarian serous carcinoma	PDE4B PDE4D MYO18B	6.39e-04	42	118	3	EFO_0004920, EFO_1001516, GO_0097328, MONDO_0009354
Disease	Tachycardia, Ventricular	RYR2 SCN5A	8.52e-04	11	118	2	C0042514
Disease	insomnia, bilirubin measurement	MROH2A UGT1A4	8.52e-04	11	118	2	EFO_0004570, EFO_0004698
Disease	Long QT Syndrome	RYR2 SCN5A	8.52e-04	11	118	2	C0023976
Disease	QRS-T angle	RYR2 SCN5A MYO18B MMP15	8.82e-04	106	118	4	EFO_0020097
Disease	salicylurate measurement	RYR2 CCT5	1.20e-03	13	118	2	EFO_0010532
Disease	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2K	DAG1 POMGNT2	1.40e-03	14	118	2	C1836373
Disease	alpha-Dystroglycanopathies	DAG1 POMGNT2	1.40e-03	14	118	2	C2936406
Disease	Fukuyama Type Congenital Muscular Dystrophy	DAG1 POMGNT2	1.40e-03	14	118	2	C0410174
Disease	Muscle eye brain disease	DAG1 POMGNT2	1.40e-03	14	118	2	C0457133
Disease	Muscular Dystrophy-Dystroglycanopathy (Congenital with Brain and Eye Anomalies) Type A, 1	DAG1 POMGNT2	1.40e-03	14	118	2	C4284790
Disease	Walker-Warburg congenital muscular dystrophy	DAG1 POMGNT2	1.61e-03	15	118	2	C0265221
Disease	infant head circumference	STRBP PLCG1	1.61e-03	15	118	2	EFO_0004577
Disease	Cardiomyopathies	AVPR2 RYR2 EPG5 SCN5A	1.87e-03	130	118	4	C0878544
Disease	Inborn Errors of Metabolism	AGXT2 PLA2G4A	2.07e-03	17	118	2	C0025521
Disease	cortical thickness change measurement	CCDC50 PARD3B	2.33e-03	18	118	2	EFO_0021501
Disease	Microcephaly	TUBG1 PLK4 STAG2	2.48e-03	67	118	3	C0025958
Disease	Brugada syndrome	SCN5A MYO18B	2.59e-03	19	118	2	MONDO_0015263
Disease	exercise test	RYR2 CNTN5	2.87e-03	20	118	2	EFO_0004328
Disease	systemising measurement	TSHZ3 FATE1	3.17e-03	21	118	2	EFO_0010221
Disease	Seckel syndrome	PLK4 PCNT	3.48e-03	22	118	2	C0265202
Disease	glioma	FAM20C CYP4F12	3.48e-03	22	118	2	EFO_0005543
Disease	Malignant neoplasm of breast	ADAT3 AVPR2 STRBP MCF2L2 MANEA EPG5 LIPE CCT5 ASL TOX3 PLA2G4A	3.90e-03	1074	118	11	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
LMVRDGRASVHSMIS	TPST1	181	O60507
SEANELAMLMARAHS	AGXT2	171	Q9BYV1
STQERAAMQSHMERA	ADAT3	166	Q96EY9
DMDSQTRHMALSSLF	EPG5	2256	Q9HCE0
DSMRMVEISHFLTLS	ARL5C	131	A6NH57
MTVHFTSTLMALIRT	CACNA1E	1801	Q15878
MEVAQANRHMSLLTA	DCTN1	576	Q14203
MKEAVSTPSRMAHRD	CCDC50	156	Q8IVM0
SVQALDVAMRHLASM	AGO1	156	Q9UL18
NAASDAEMNHRSSMR	AKAP13	1571	Q12802
DMTVHFTSTLMALIR	CACNA1B	1786	Q00975
VVREGRSVMLTSHSM	ABCA7	1971	Q8IZY2
HSSMSSSMARALVLL	CCDC27	56	Q2M243
SSADLMIRNILLMHA	CNTN5	631	O94779
SRMVHRAGDEMSSLL	ZFYVE28	346	Q9HCC9
HMNSMSHLRLRTGLT	LEMD3	891	Q9Y2U8
HIESMIRMAEAHARI	MCM2	766	P49736
NSVNMAAHTLMILSR	NPAT	1326	Q14207
KSNHEAMETLRRSMS	PARD3B	561	Q8TEW8
MDMHSARLDSFLSQL	INKA1	1	Q96EL1
HIVADATSSRSMMDR	ISOC1	231	Q96CN7
RMDKHMAISRQLSTE	MTUS1	1191	Q9ULD2
DTMLRHLRATDAMKN	LRRK1	1286	Q38SD2
HVRTLEMLSLDASAM	LRSAM1	171	Q6UWE0
ASLCMTHLSRMAEDL	ASL	246	P04424
PSRHMSTMRSAQILA	MMP15	66	P51511
ATRSRSRTNMLMDLH	GAPVD1	481	Q14C86
LHRMRSFSEVELHNM	DAG1	211	Q14118
RSMLSTEDLLMSHTR	MCF2L2	231	Q86YR7
STHLRLLVMFIMSAG	PCNX4	286	Q63HM2
SASEMVMRARDSVYH	LHX9	141	Q9NQ69
SALTRMCMRHRSIET	MTSS2	76	Q765P7
AMHTLFMREHNRLAT	EPX	386	P11678
KRMLNRELTHLSEMS	PDE4B	251	Q07343
MLNRELTHLSEMSRS	PDE4D	311	Q08499
RRHSSMARIHSMTIE	PDE8A	376	O60658
MITLILATDMARHAE	PDE9A	416	O76083
VVRLVSNASMLVSMH	POMGNT2	331	Q8NAT1
HLSSLEREMTFRTEM	DPY19L2	136	Q6NUT2
TREHAMEALLNTSTM	HUWE1	1331	Q7Z6Z7
VAEISSHMRESFLMS	PCNT	1231	O95613
THMRQMRSASIGVLA	MANEA	171	Q5SRI9
AVRLIMDSLHMAARE	MFN2	371	O95140
NTISRMDRHRVMDDH	RIMS2	1056	Q9UQ26
KVRNMSESMAAAHRT	NDFIP2	316	Q9NV92
FMDAMSHICRISRTL	DNAH1	2561	Q9P2D7
RSFIHDTTMENIMLR	GABRR3	151	A8MPY1
HLSDLIRMAFMAATD	HEATR5B	1291	Q9P2D3
LHSLENSLMDMIRTD	CPEB3	346	Q8NE35
LHMMVFTDALHRERS	DELEC1	26	Q9P2X7
DSSHRILDVMDMTIF	FAM20C	436	Q8IXL6
SARLDMFEHISLMTL	CYP4F11	186	Q9HBI6
SSRLDMFEHISLMTL	CYP4F12	186	Q9HCS2
MELHETMASLQSRLR	CEP250	1316	Q9BV73
RSVLNGSHAMMDLLV	COBL	76	O75128
RVHESMRISTMTSHD	HYAL4	281	Q2M3T9
DVSMARMRTLHAALG	A3GALT2	171	U3KPV4
RMTESHLMVTSQSLR	APPL2	531	Q8NEU8
ERLTFGESLMTHAMT	BLMH	361	Q13867
ALMLSMTGADSHAKR	HTN3	11	P15516
FDMHSLESSLIDIMR	CPEB4	381	Q17RY0
SARLDMFEHISLMTL	CYP4F3	186	Q08477
HLVIAEMMELGSRSR	FATE1	31	Q969F0
HSSEDMSKMVSRRNV	CT62	81	P0C5K7
AMQRSHSDLVRSTQM	GPRIN2	116	O60269
IDMSNVTLSRDLHAM	RYR2	2826	Q92736
ALMISMISADSHEKR	HTN1	11	P15515
SRLIHNMDLRTMTQS	LIPE	296	Q05469
HRMIMALVSDSALFN	PLA2G4A	466	P47712
FARTMLHSLMGRLQS	MROH2A	1186	A6NES4
SRDSSTEAHRRAMKM	TAS2R42	221	Q7RTR8
SVDRTRHLMSFLTMM	SPON1	306	Q9HCB6
MRGAHLTALEMLTAF	MRPL53	76	Q96EL3
AMHKDVDTSMLRRAI	SESN1	391	Q9Y6P5
HSSALRQLLNSMMTV	STK16	261	O75716
SSRVRTSFLENMIHM	GPRASP2	651	Q96D09
VKNSSHVDRRSMPSM	PLEKHA7	621	Q6IQ23
SIDRRHVMLLSDLMT	POLR3A	1281	O14802
MNHLSLTRGLSRTSM	SCN5A	506	Q14524
AIHMSLLEMRRSVAE	KIAA1217	641	Q5T5P2
SHIMAAKAVANTMRT	CCT5	36	P48643
AMDFVTSAANLRMHI	UBA2	351	Q9UBT2
RSFHERSSNMLSMEN	SPATA31D4	751	Q6ZUB0
MRSIRSFANDDRHVM	STRBP	1	Q96SI9
HSRKDMNDTLTSALM	NOM1	391	Q5C9Z4
ITHVVSSTMMAGLLR	SHCBP1	331	Q8NEM2
MERCHSAEMLSVSKR	PLK4	396	O00444
MSLSRSEEMHRLTEN	BAIAP2	1	Q9UQB8
ASRLTRHRSAVMESM	CENPBD1P	76	B2RD01
RHRSAVMESMEQLLS	CENPBD1P	81	B2RD01
DFSDIMVTIRSHMLT	SLC25A12	181	O75746
SAATLHMAVRDLMRS	CHST5	106	Q9GZS9
MVRDGRASVHSMITR	TPST2	181	O60704
RSFHERSSNMLSMEN	SPATA31D3	751	P0C874
MLSVHDIRLADMDLR	TRAF3	391	Q13114
TVNAHMMLDKARRDT	RPA4	161	Q13156
LMMANHTSISSLFER	TUBG1	376	P23258
SHLMRSGSVMERRAI	TRAPPC14	526	Q8WVR3
RHTSTLAAMKLMTAL	STAG2	216	Q8N3U4
SLLQSMEMAHSGSLR	SYBU	371	Q9NX95
VGSSRLRHIMAEMIA	PLEKHG4B	801	Q96PX9
DLRSNSERDLETHMM	SPATA31D1	796	Q6ZQQ2
GLSDLRHMRMTRSVD	SLC50A1	26	Q9BRV3
MHVMQKRSRAIHSSD	WAS	471	P42768
ASLTRAQAEHMLMRV	PLCG1	671	P19174
HPKSSDTLAMDMRVR	PRRC2B	761	Q5JSZ5
SSSLAAMLIGILHMR	TEX10	646	Q9NXF1
RAFRHTSTLAAMKLM	STAG1	216	Q8WVM7
RDLRQLHQMSSSSMS	REL	531	Q04864
SLIMRSIVHMTDAAR	TOX3	151	O15405
EMVSSIQASMDRHLR	VCPIP1	1111	Q96JH7
ELRRRMSVMDSHAVA	SNX19	141	Q92543
ERMHISRFTGLSMTT	TSHZ3	931	Q63HK5
VSMAHSRSATRFSMV	MYO18B	706	Q8IUG5
MRKHVLAASFSMLSL	NDP	1	Q00604
FRHLLSSDQMMDSIL	PRKDC	531	P78527
REHTDTLRHLNVMLM	ULK2	821	Q8IYT8
HAVTRATKMLTATAM	USP24	891	Q9UPU5
MLSSRAEAAMTAADR	USP30	1	Q70CQ3
LMTLASGSMVFILHR	VN1R3	196	Q9BXE9
KRMSVAHMSLQAAAA	RHBDF2	236	Q6PJF5
AMTRRSLAALKNMAH	WDR7	631	Q9Y4E6
SSYMILAMTLDRHRA	AVPR2	126	P30518
IDRSSSMSGISMHRV	VWA5B1	366	Q5TIE3
HAVHLRMSTRDRNMA	WDR64	606	B1ANS9
SRSMAIMNNVSLALH	UGT1A4	111	P22310
ELQEAMARSMESRSH	VPS13D	221	Q5THJ4
SINLVSHSMMAFDTR	VPS13D	2331	Q5THJ4
AETLMFSEHAVISMR	KCNJ3	191	P48549
DMLHTVTDMVRLAFT	MX1	471	P20591
SIRHEVTRLTSENMM	MYO5C	1196	Q9NQX4