Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	DAGKc	SPHK2 DGKK AGK	4.32e-05	14	94	3	SM00046
Domain	Diacylglycerol_kinase_cat_dom	SPHK2 DGKK AGK	5.38e-05	15	94	3	IPR001206
Domain	DAGK_cat	SPHK2 DGKK AGK	5.38e-05	15	94	3	PF00781
Domain	DAGK	SPHK2 DGKK AGK	5.38e-05	15	94	3	PS50146
Domain	SH3_2	SHANK1 SRMS MYO15B CASKIN2 FCHSD1	7.32e-05	86	94	5	IPR011511
Domain	SH3_2	SHANK1 SRMS MYO15B CASKIN2 FCHSD1	7.32e-05	86	94	5	PF07653
Domain	NAD/diacylglycerol_kinase	SPHK2 DGKK AGK	7.98e-05	17	94	3	IPR016064
Domain	FAM47	FAM47A FAM47C	1.49e-04	4	94	2	PF14642
Domain	FAM47	FAM47A FAM47C	1.49e-04	4	94	2	IPR032743
Domain	PH	PHLDB3 CNKSR1 DOK7 TRIOBP ARHGEF40 DGKK PSD4	5.10e-04	278	94	7	SM00233
Domain	PH_DOMAIN	PHLDB3 CNKSR1 DOK7 TRIOBP ARHGEF40 DGKK PSD4	5.21e-04	279	94	7	PS50003
Domain	PH_domain	PHLDB3 CNKSR1 DOK7 TRIOBP ARHGEF40 DGKK PSD4	5.32e-04	280	94	7	IPR001849
Domain	-	PHLDB3 CNKSR1 DOK7 APBB1 TRIOBP ARHGEF40 DGKK PSD4	7.97e-04	391	94	8	2.30.29.30
Domain	PH_dom-like	PHLDB3 CNKSR1 DOK7 APBB1 TRIOBP ARHGEF40 DGKK PSD4	1.38e-03	426	94	8	IPR011993
Domain	-	SEMA4F STXBP5L WDR76 EML3 BOP1 CFAP44 SON	1.46e-03	333	94	7	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEMA4F STXBP5L WDR76 EML3 BOP1 CFAP44 SON	1.51e-03	335	94	7	IPR015943
Domain	WW	SMURF1 APBB1 TCERG1	1.71e-03	47	94	3	PF00397
Domain	WW	SMURF1 APBB1 TCERG1	1.81e-03	48	94	3	SM00456
Domain	WW_DOMAIN_2	SMURF1 APBB1 TCERG1	2.16e-03	51	94	3	PS50020
Domain	WW_DOMAIN_1	SMURF1 APBB1 TCERG1	2.16e-03	51	94	3	PS01159
Domain	WW_dom	SMURF1 APBB1 TCERG1	2.28e-03	52	94	3	IPR001202
Domain	Ion_trans_dom	MCOLN1 KCNC2 KCND2 CACNA1G	2.63e-03	114	94	4	IPR005821
Domain	Ion_trans	MCOLN1 KCNC2 KCND2 CACNA1G	2.63e-03	114	94	4	PF00520
Domain	Post-SET_dom	SETD1B KMT2D	2.87e-03	16	94	2	IPR003616
Domain	PostSET	SETD1B KMT2D	2.87e-03	16	94	2	SM00508
Domain	POST_SET	SETD1B KMT2D	2.87e-03	16	94	2	PS50868
Domain	Channel_four-helix_dom	KCNC2 KCND2 CACNA1G	2.97e-03	57	94	3	IPR027359
Domain	-	KCNC2 KCND2 CACNA1G	2.97e-03	57	94	3	1.20.120.350
Domain	WD40_repeat_dom	STXBP5L WDR76 EML3 BOP1 CFAP44 SON	3.89e-03	297	94	6	IPR017986
Domain	SH3	SHANK1 SRMS MYO15B CASKIN2 FCHSD1	4.71e-03	216	94	5	SM00326
Domain	SH3	SHANK1 SRMS MYO15B CASKIN2 FCHSD1	4.71e-03	216	94	5	PS50002
Domain	SAM_1	SHANK1 CNKSR1 CASKIN2	4.88e-03	68	94	3	PF00536
Domain	DS_RBD	ADAD1 SON	4.95e-03	21	94	2	PS50137
Domain	SH3_domain	SHANK1 SRMS MYO15B CASKIN2 FCHSD1	5.09e-03	220	94	5	IPR001452
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PHLDB3 SEMA4F SPHK2 SETD1B CDK12 PFAS RNF40 ANKLE1 PPP6R1 DYSF EML3 CIC JUND TNRC18 ARHGEF40 KMT2D MAP1S SYNJ1 EIF4G1 SLC45A1	4.47e-11	1105	100	20	35748872
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	SETD1B PFAS TNIP1 RNF40 TACC2 PPP6R1 CIC TCERG1 SYNJ1 ATF7IP KDM2B BSN CFAP44 SLX4	1.56e-09	588	100	14	38580884
Pubmed	Functional proteomics mapping of a human signaling pathway.	CNKSR1 CPXM2 CDK12 TOM1 SMURF1 TNIP1 KMT2D PELP1 ATF7IP GORASP1 EIF4G1 SON	1.40e-07	591	100	12	15231748
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ATF5 PTPN22 CCDC141 CIC PRR14 TNRC18 MAP1S BSN SON	4.38e-06	430	100	9	35044719
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	SHANK1 RETREG2 SEPTIN5 STXBP5L APBB1 TRIOBP MRPS35 TACC2 PPP6R1 TNRC18 MAP1S SYNJ1 KCND2 BSN	4.85e-06	1139	100	14	36417873
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ZBTB2 TNIP1 PPP6R1 CIC JUND KMT2D LIN37 TCERG1 PELP1 EIF4G1 FOXH1 FOXJ1	6.70e-06	857	100	12	25609649
Pubmed	Differential regulation of action potential firing in adult murine thalamocortical neurons by Kv3.2, Kv1, and SK potassium and N-type calcium channels.	KCNC2 CACNA1G	8.18e-06	2	100	2	17761775
Pubmed	An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability.	SETD1B KDM2B	8.18e-06	2	100	2	27106595
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SETD1B PPP6R1 KCND2 ZFHX2 SON	1.30e-05	104	100	5	10470851
Pubmed	Human transcription factor protein interaction networks.	MRPS35 TNIP1 PPP6R1 CIC JUND KMT2D LIN37 TCERG1 ATF7IP DGKK EIF4G1 AGK KDM2B PRKCSH SLX4	1.42e-05	1429	100	15	35140242
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	MICAL1 RETREG2 SEPTIN5 APBB1 PPP6R1 MAP3K12 CIC PRR14 GORASP1 EIF4G1 BOP1 PRKCSH MAP4K2	2.06e-05	1124	100	13	21900206
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TNIP1 RNF40 PPP6R1 CIC KMT2D SYNJ1 ATF7IP KDM2B	2.89e-05	418	100	8	34709266
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	CEP290 TOM1 MRPS35 PFAS CIC NCCRP1 TNRC18 SYNJ1 CASKIN2 OTOG	3.04e-05	689	100	10	36543142
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	ATF5 CCDC141 ATF7IP	3.41e-05	22	100	3	12812986
Pubmed	Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.	TNIP1 PTPN22	4.89e-05	4	100	2	23055271
Pubmed	IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ.	SHANK1 BSN	8.14e-05	5	100	2	21940441
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	CDK12 CIC KMT2D KDM2B	9.93e-05	83	100	4	28794006
Pubmed	ATF4 interacts with Abro1/KIAA0157 scaffold protein and participates in a cytoprotective pathway.	ATF5 JUND	1.22e-04	6	100	2	22974638
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CDK12 TRIOBP RNF40 CASKIN2 KDM2B BOP1 CACNA1G BSN	1.49e-04	529	100	8	14621295
Pubmed	A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter.	TICAM1 TNIP1	1.70e-04	7	100	2	15474016
Pubmed	Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea.	SHANK1 BSN	2.27e-04	8	100	2	23217150
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	SETD1B KMT2D	2.27e-04	8	100	2	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	SETD1B KMT2D	2.27e-04	8	100	2	22266653
Pubmed	Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.	CDK12 RNF40 CIC LIN37 PELP1 ATF7IP PRKCSH	2.34e-04	425	100	7	24999758
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	ZBTB2 PELP1 ATF7IP SLX4	2.55e-04	106	100	4	19394292
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	SETD1B KMT2D	2.91e-04	9	100	2	22665483
Pubmed	Superresolution imaging of chemical synapses in the brain.	SHANK1 BSN	2.91e-04	9	100	2	21144999
Pubmed	FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis.	FSCB CABYR	2.91e-04	9	100	2	17855365
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SHANK1 CNKSR1 CEP290 APBB1 TRIOBP MRPS35 RNF40 MAP1S TCERG1 SYNJ1 EIF4G1 SLX4	3.23e-04	1285	100	12	35914814
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SEPTIN5 CDK12 TOM1 TRIOBP MRPS35 CIC TCERG1 CRACDL EIF4G1 KDM2B BOP1 PRR11 SON	3.61e-04	1497	100	13	31527615
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CDK12 APBB1 PFAS TACC2 PPP6R1 CIC TCERG1 SYNJ1 ATF7IP SON	3.64e-04	934	100	10	33916271
Pubmed	Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.	ZBTB2 SETD1B JUND KMT2D	3.97e-04	119	100	4	23508102
Pubmed	Synaptic vesicle trafficking and Parkinson's disease.	SEPTIN5 SYNJ1	4.43e-04	11	100	2	21563316
Pubmed	The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics.	TOM1 PPP6R1 ARHGEF40 SYNJ1	4.78e-04	125	100	4	29467281
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	RETREG2 TRIOBP MRPS35 TACC2 EML3 LIN37 MAP1S GORASP1 EIF4G1 PRKCSH SLX4	4.93e-04	1155	100	11	20360068
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CDK12 TRIOBP TNIP1 SYNJ1 CACNA1G	4.95e-04	225	100	5	12168954
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	SEPTIN5 STXBP5L MCOLN1 SYNJ1 KCND2 BSN	5.12e-04	347	100	6	17114649
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	CNKSR1 APBB1 MRPS35 CIC KMT2D AGK KDM2B BSN	5.20e-04	638	100	8	31182584
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	SETD1B KMT2D	5.30e-04	12	100	2	27563068
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZBTB2 CEP290 PFAS TNIP1 TNRC18 MYO15B SLX4	5.68e-04	493	100	7	15368895
Pubmed	New nomenclature for chromatin-modifying enzymes.	SETD1B KMT2D KDM2B	6.03e-04	57	100	3	18022353
Pubmed	Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.	CEP290 TACC2	6.25e-04	13	100	2	17920017
Pubmed	Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.	ADAD1 PTPN22 BSN	6.34e-04	58	100	3	17554300
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	CNKSR1 CDK12 TNIP1 TACC2 EIF4G1 BOP1 SON	6.39e-04	503	100	7	16964243
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	NCCRP1 KMT2D PELP1 EIF4G1	7.12e-04	139	100	4	25476789
Pubmed	A murine ATFa-associated factor with transcriptional repressing activity.	ATF5 ATF7IP	7.28e-04	14	100	2	10777215
Pubmed	A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.	CPXM2 BSN	9.57e-04	16	100	2	25082827
Pubmed	H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.	SETD1B KMT2D	9.57e-04	16	100	2	24368734
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	CDK12 APBB1 MAP1S TCERG1	1.04e-03	154	100	4	16055720
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CDK12 APBB1 TNIP1 KMT2D TCERG1 SYNJ1 KDM2B	1.06e-03	549	100	7	38280479
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	RNF40 CIC TNRC18 KMT2D KDM2B	1.09e-03	268	100	5	33640491
Pubmed	From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map.	C21orf58 SON	1.22e-03	18	100	2	11707072
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	GORASP1 PRKCSH	1.22e-03	18	100	2	31666509
Pubmed	Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.	SHANK1 SYNJ1	1.22e-03	18	100	2	27984743
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	CEP290 RNF40 WDR76 CIC JUND KMT2D LIN37 TCERG1 PELP1 KDM2B SON	1.25e-03	1294	100	11	30804502
Pubmed	EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.	EML3 MAP1S	1.36e-03	19	100	2	18445686
Pubmed	ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.	CIC MMP3	1.36e-03	19	100	2	22014525
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	MRPS35 PPP6R1 JUND TNRC18 PELP1	1.36e-03	282	100	5	23667531
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	SETD1B KMT2D	1.50e-03	20	100	2	29785026
Pubmed	Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.	ABHD17A SEMA4F RETREG2 MRPS35 RNF40 SLC16A11	1.55e-03	430	100	6	16303743
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	CDK12 TACC2 TCERG1 PELP1 EIF4G1 AGK BOP1 SON	1.58e-03	759	100	8	35915203
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2D KDM2B	1.66e-03	21	100	2	27626377
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	CDK12 CIC TCERG1 PELP1 ATF7IP EIF4G1 FOXH1 SLX4 SON	1.74e-03	954	100	9	36373674
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CDK12 CIC JUND KMT2D MAP1S EIF4G1 KDM2B SON	1.79e-03	774	100	8	15302935
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	PFAS RNF40 EIF4G1 PRKCSH	1.81e-03	179	100	4	36261009
Pubmed	Structural basis for activity regulation of MLL family methyltransferases.	SETD1B KMT2D	1.82e-03	22	100	2	26886794
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHANK1 SEPTIN5 TRIOBP PPP6R1 PELP1 SYNJ1 ATF7IP EIF4G1 BSN	1.85e-03	963	100	9	28671696
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	TNRC18 KMT2D	1.99e-03	23	100	2	9225980
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CIC SYNJ1 KCND2	2.05e-03	87	100	3	12465718
Pubmed	Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.	ADAD1 PTPN22	2.35e-03	25	100	2	21829393
Pubmed	Holoprosencephaly Overview	KMT2D FOXH1	2.35e-03	25	100	2	20301702
Pubmed	Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal.	KCNC2 KCND2	2.54e-03	26	100	2	7905852
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	SETD1B RNF40 NCCRP1 TCERG1 SYNJ1 BOP1	2.54e-03	475	100	6	31040226
Pubmed	Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons.	ATF5 STXBP5L	2.74e-03	27	100	2	23090999
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	CDK12 PFAS PPP6R1 ARHGEF40 TCERG1 CASKIN2 GORASP1	2.76e-03	650	100	7	38777146
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EML3 TCERG1 PELP1 ATF7IP EIF4G1	2.76e-03	332	100	5	32786267
Interaction	TOP3B interactions	PHLDB3 SEMA4F SPHK2 SETD1B CDK12 PFAS RNF40 ANKLE1 PPP6R1 DYSF EML3 CIC JUND TNRC18 ARHGEF40 KMT2D MAP1S PELP1 SYNJ1 EIF4G1 SLC45A1	5.33e-06	1470	97	21	int:TOP3B
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	SHANK1 NPHS1 PHLDB3 SPHK2 ATF5 ERFL PPP6R1 CIC NCCRP1 LIN37	2.81e-04	1192	100	10	chr19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ABHD17A C19orf67 TICAM1 ANKLE1 MCOLN1 JUND MAP1S PRKCSH	3.64e-04	797	100	8	chr19p13
Cytoband	19q13.2	SPHK2 ERFL CIC NCCRP1	4.71e-04	164	100	4	19q13.2
Cytoband	17q25.1	MYO15B CASKIN2 FOXJ1	7.56e-04	81	100	3	17q25.1
GeneFamily	Ferlin family	DYSF FER1L4	1.89e-04	6	65	2	828
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	C21orf58 WDR76 FSCB MAP1S DLK2 MAP4K2	5.69e-06	198	100	6	d5e125f0c4f41b47d567568d0838adcca7655f6d
ToppCell	Striatum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Striatum / BrainAtlas - Mouse McCarroll V32	SHANK1 VWC2 KCNC2 CACNA1G FCHSD1	1.26e-05	133	100	5	d5326a6ccada5ae6d3e8f7d4a858c90050e23c5b
ToppCell	Control-Endothelial-Epi-like\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABHD17A ZBTB2 PPP6R1 WDR76 ARHGEF40	2.80e-05	157	100	5	4d02c50d5d1b892ea241e98724386d8a5a156a46
ToppCell	Control-Endothelial-Epi-like-Alv_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABHD17A ZBTB2 PPP6R1 WDR76 ARHGEF40	2.80e-05	157	100	5	2c369660c752c0fb3bd798a561d3359e2f9aa983
ToppCell	356C-Myeloid-Dendritic-cDC_activated\|356C / Donor, Lineage, Cell class and subclass (all cells)	MICAL1 NPIPB7 NCCRP1 KDM2B NUB1	3.76e-05	167	100	5	43a9375fdbafd7450c553e4620e21537e08639dd
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHANK1 NPHS1 COL7A1 CCDC141 NCCRP1	4.45e-05	173	100	5	c62e3ffed55bbb00dcaef6da0aab8446f3f55085
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHANK1 NPHS1 COL7A1 CCDC141 NCCRP1	4.45e-05	173	100	5	f612d4ea9ab8dcde475f4118bca3e49be786e7fa
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHANK1 NPHS1 COL7A1 CCDC141 NCCRP1	4.57e-05	174	100	5	165e14cad57e90aa247dcecfaa3c2e8ff2a470ad
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHANK1 NPHS1 COL7A1 CCDC141 NCCRP1	4.57e-05	174	100	5	4289dfc7613db4bb3d706b9b65d06e84c0c53558
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DYSF CABYR UBTD1 CASKIN2 MAP4K2	5.09e-05	178	100	5	60263c0bb9de3a57ba2ba543262a2ace0066fd85
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL7A1 CPXM2 PMEPA1 CACNA1G MMP3	5.51e-05	181	100	5	3462aa1c08fbaf613b6278ab2c7a5a0940bf537d
ToppCell	PND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COL7A1 CPXM2 PMEPA1 CACNA1G MMP3	5.51e-05	181	100	5	6730e249cac55ae892cc567d9211615882f3dab4
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 APBB1 JUND FER1L4 DLK2	5.80e-05	183	100	5	bc24145855bf4d027a8058bf92bc796c10f241bb
ToppCell	droplet-Lung-LUNG-30m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNKSR1 C21orf58 SLC16A11 CFAP44 FOXJ1	5.80e-05	183	100	5	3991830726d05cf19606d540de04093985b7bdeb
ToppCell	droplet-Lung-LUNG-30m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNKSR1 C21orf58 SLC16A11 CFAP44 FOXJ1	5.80e-05	183	100	5	cc844f54c7564bf432b179ca63bc7c4b9b8cfdd9
ToppCell	facs-Marrow-T_cells-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPHS1 APBB1 JUND FER1L4 DLK2	5.80e-05	183	100	5	4c325ee6da070513097a11445ec95b0415ffd8a2
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-Lymphoid_DC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL7A1 NCCRP1 KDM2B ZFHX2 NUB1	6.11e-05	185	100	5	48de4d9fad55077732bf64eca4919103ecbc1512
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CPXM2 CRACDL SLAIN1 SLC16A11 FOXJ1	6.59e-05	188	100	5	3cfba3addcc9058f4ec31ad96261f79988f551a0
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell-Epi-Ciliated\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CNKSR1 APBB1 CABYR CFAP44 FOXJ1	7.28e-05	192	100	5	a22952b885c8a7704a4a9602fa03e4f2c786bf75
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-ciliated_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CNKSR1 APBB1 CABYR CFAP44 FOXJ1	7.28e-05	192	100	5	dcf2d0c2e8868104c4dba410456207f0d947029a
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP5L KCNC2 CRACDL DLK2 BSN	7.46e-05	193	100	5	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP5L KCNC2 CRACDL DLK2 BSN	7.46e-05	193	100	5	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STXBP5L KCNC2 CRACDL DLK2 BSN	7.46e-05	193	100	5	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CNKSR1 DLK2 SLC16A11 CFAP44 FOXJ1	7.83e-05	195	100	5	ed052c6d3dc104b02e34b645abfdee477af050c6
ToppCell	distal-2-Endothelial-Lymphatic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CPXM2 CCDC141 UBTD1 DLK2 SLC16A11	7.83e-05	195	100	5	8e0f67a67af3bc0b16f48a621f74540f136383b7
ToppCell	390C-Endothelial_cells-Endothelial-A_(Artery)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	CPXM2 TRIOBP DYSF CASKIN2 CRACDL	8.42e-05	198	100	5	f83956c4b13b5d0a0c6e3d9f580dbf99649ef175
ToppCell	390C-Endothelial_cells-Endothelial-A_(Artery)\|390C / Donor, Lineage, Cell class and subclass (all cells)	CPXM2 TRIOBP DYSF CASKIN2 CRACDL	8.42e-05	198	100	5	5b5ccce5de82ea041465e656147cec3b8beb865b
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-4\|TCGA-Skin / Sample_Type by Project: Shred V9	TOM1 PPP6R1 MAP1S PELP1 PRKCSH	8.62e-05	199	100	5	bbda9060918797303984ca2b64e9bb73fdacd0c4
Disease	triglyceride measurement, coronary artery disease	SETD1B MAP4K2	6.39e-05	4	97	2	EFO_0001645, EFO_0004530
Disease	smoking cessation	CPXM2 CDK12 TOM1 CCDC141 PMEPA1 KCNC2 BSN	1.01e-04	325	97	7	EFO_0004319
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	DYSF FER1L4	2.22e-04	7	97	2	DOID:11724 (implicated_via_orthology)
Disease	crescentic glomerulonephritis (biomarker_via_orthology)	JUND MMP3	2.96e-04	8	97	2	DOID:13139 (biomarker_via_orthology)
Disease	spondylosis	DOK7 KCNC2 PSD4	3.11e-04	40	97	3	MONDO_0002253
Disease	serum albumin measurement	NPHS1 COL7A1 SEPTIN5 CDK12 DOK7 WDR76 DYSF BSN	7.57e-04	592	97	8	EFO_0004535
Disease	Malignant neoplasm of breast	MICAL1 COL7A1 TICAM1 TNIP1 TACC2 DYSF MCOLN1 FSCB CIC KMT2D MMP3	8.06e-04	1074	97	11	C0006142
Disease	ulcerative colitis	ADAD1 CPXM2 TOM1 SMURF1 TNRC18 BSN	8.51e-04	335	97	6	EFO_0000729
Disease	response to peritoneal dialysis, peritoneal solute transfer rate	KCNC2 KDM2B	1.09e-03	15	97	2	EFO_0600089, EFO_0600090
Disease	1-Methylhistidine measurement	CDK12 KCND2	1.41e-03	17	97	2	EFO_0021543
Disease	congenital heart disease (implicated_via_orthology)	RNF40 KMT2D SON	1.54e-03	69	97	3	DOID:1682 (implicated_via_orthology)
Disease	psoriasis	SPHK2 TNIP1 AGK SLC45A1 SON	2.11e-03	273	97	5	EFO_0000676
Disease	systemic scleroderma (is_implicated_in)	PTPN22 MMP3	2.82e-03	24	97	2	DOID:418 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
LEPEPEPEPPLLCTS	BOP1	26	Q14137
PGPDAPPLTPETLQT	ERFL	156	A0A1W2PQ73
TPLPEPGTSELRDPL	RNF40	136	O75150
EVPSALPGPTAPTLP	B4GALT2	81	O60909
PPSPTTEGPSLQPDL	AKAP2	776	Q9Y2D5
GPTERPPNEPEETPV	AGK	256	Q53H12
LPPELPGGDLSPPDS	CDK12	671	Q9NYV4
VATLSEPVPPPGPEL	ARHGEF40	1101	Q8TER5
ADPGPPSLPVPLETV	ANKLE1	186	Q8NAG6
PEATYSLVPEPEPGP	ABHD17A	31	Q96GS6
DEPEPRILETSGPPP	ADAD1	166	Q96M93
PFPPAPEGLTAPEIE	CABYR	471	O75952
EDLSSPPGLPEPLES	APBB1	171	O00213
EEPLPEIFIPSTPSP	CFAP44	736	Q96MT7
GTLPQPSPTPPDLEA	ATF5	86	Q9Y2D1
EPELETFSPPLPAGP	CPXM2	51	Q8N436
DEIPPPLPVRTPESF	PTPN22	611	Q9Y2R2
PPPPPSDDLTLLESS	MCOLN1	201	Q9GZU1
PAEEPLSSPPGTLPP	MAP4K2	416	Q12851
GSLPPELPLSPEDSL	NUB1	531	Q9Y5A7
SPEEGTPPPLVPECD	PHLDB3	6	Q6NSJ2
EPPETGVSHLRPEPP	FAM47C	441	Q5HY64
EPPETGVSHLRPEPP	FAM47C	621	Q5HY64
PSGEPEDQLPTEPPS	NPHS1	1041	O60500
LTPEVAPELAPEPTP	DGKK	141	Q5KSL6
ASPPATPPPETGELL	SLC16A11	436	Q8NCK7
TGSEPPLSPPERLPI	KCNC2	546	Q96PR1
EAPGPLPSLPLEPSL	LRP10	636	Q7Z4F1
ERECSPSSPLPPLPE	LIN37	131	Q96GY3
PSSPLPPLPEDEEGS	LIN37	136	Q96GY3
ESLEPPSPFELLEPP	MAP1S	216	Q66K74
EEAVPTPPLPSSERP	FOXH1	201	O75593
LPPSAEESPSEEPPA	FSCB	351	Q5H9T9
PTDLPAPSAPDLTEP	PRKCSH	286	P14314
ELPPDLLPEPSAGLP	FER1L4	736	A9Z1Z3
VPDVPSFGESPPLSP	JUND	246	P17535
SLYGPPPDSPETPLV	MMP3	261	P08254
LEGSLGEPTPLPPPT	BSN	521	Q9UPA5
SLPSPAAPEAPELPE	NCCRP1	46	Q6ZVX7
PTPPVTTPEGDDRPE	KCND2	601	Q9NZV8
PPDPGLAITPEPTTE	LRRC37B	446	Q96QE4
ETPSTEVPPDPEPGV	MICAL1	666	Q8TDZ2
PPECLLTPLPPSVDD	NPIPB7	266	O75200
EDPILAPSGTPPPTI	PELP1	736	Q8IZL8
PFPTAIPEGDTTPPE	CRACDL	401	Q6NV74
LSSVSGPSPEPPPLD	CASKIN2	876	Q8WXE0
ALPPGPTPEDSPSLE	GORASP1	231	Q9BQQ3
LPPTISLSDGEEPPP	PMEPA1	146	Q969W9
PPLPLPEDPGTLSAE	MYO15B	1196	Q96JP2
ELLGPPGPPELSDPE	FCHSD1	606	Q86WN1
PPISPPPDSLPLDDG	KDM2B	1046	Q8NHM5
PDDISLPPLPGSPES	CCDC141	1211	Q6ZP82
ITIDPPESQGPRTPP	CACNA1G	2311	O43497
EEATGSIPDPSLPLP	CEP290	1436	O15078
PELPPTGILPTASPS	C21orf58	176	P58505
LPLDPGETPPPDALE	C19orf67	11	A6NJJ6
PRPPSTLLPTPEEQG	FOXJ1	286	Q92949
PSPSPVLEPGSEPNL	EIF4G1	266	Q04637
SSDPIPGEPVPVEPI	ATF7IP	206	Q6VMQ6
SEIPLDPPPSEVIPG	MAP3K12	796	Q12852
PEPPETGVSHLSPEP	FAM47A	201	Q5JRC9
EPPETGVSHLRPEPP	FAM47A	226	Q5JRC9
PATVVPTGPELPVSP	COL7A1	496	Q02388
LEELPSGPPPETLSL	EML3	236	Q32P44
LPVPDPPTTVDTPLG	DLK2	251	Q6UY11
LPDPSPPGPSTVEER	DOK7	216	Q18PE1
PSPPVLPEEGPGDSL	SLC45A1	346	Q9Y2W3
PTPLEPSPTLPDLDV	DYSF	136	O75923
PPECLLTPLPPSVDD	NPIPB9	281	F8W1W9
LPPSQGLPTPSDEEP	OTOG	1481	Q6ZRI0
PVPTPSLPERTPGNE	MRPS35	31	P82673
PPSPSPEDERLPLAL	SEMA4F	716	O95754
ESPIPILPLPTPDAE	SEPTIN5	326	Q99719
LPPGTSPPVDPFTTL	SYNJ1	1546	O43426
PDPALELPSTPPPSS	PRR14	221	Q9BWN1
PESPATLEPPLPEDT	PSD4	281	Q8NDX1
VGSDPAPSPSILPPV	RETREG2	456	Q8NC44
APPSPPPTLLDEVEL	SLAIN1	156	Q8ND83
EDLVPPAGSPELSPP	SETD1B	1651	Q9UPS6
PGSLDPNTDPVPTLP	SRMS	31	Q9H3Y6
SILDEPGEPPSPSLT	TRIOBP	1786	Q9H2D6
EPSQPLPLPSEGSLE	SMURF1	351	Q9HCE7
IITPEPETSPPFPDL	STXBP5L	566	Q9Y2K9
RSPPLDSDPPIPIDD	SLX4	1411	Q8IY92
SLSVPGSEDIPPPPT	SHANK1	911	Q9Y566
PTAPESELEGQPTPP	CIC	1216	Q96RK0
DSASLGPEPLPIPPE	CNKSR1	341	Q969H4
ELLPPPSPSLGSFDP	TNIP1	71	Q15025
DEGPTELPPLESPLP	TNRC18	1166	O15417
IGPELAPTPEPPEEY	VWC2	131	Q2TAL6
TLPAPVGSPEDPSDP	ZFHX2	401	Q9C0A1
ASPDPLPEPPLASVE	ZFHX2	1096	Q9C0A1
GDAPLSPDPLLSSPP	SPHK2	461	Q9NRA0
PVTAPGTPALPPTEE	TCERG1	121	O14776
GPPEEPPRELESVPS	SOGA3	141	Q5TF21
PPILSGDTPIAPTPE	TOM1	201	O60784
PPSGEIASPPELPSS	TICAM1	256	Q8IUC6
PPPGLPEVAPDATST	TICAM1	271	Q8IUC6
APPTPLPTPVDLELE	PFAS	616	O15067
PAPPTGEVADTPLEP	TACC2	1681	O95359
TEEESLEPPEPPPSV	UBTD1	131	Q9HAC8
LSLGPPPDSSPETPI	PPP6R1	411	Q9UPN7
PPTLVADETPLLPPG	WDR76	236	Q9H967
VPPPPPGEETNLEAS	ZBTB2	211	Q8N680
PPPPSPERVGISSID	PRR11	36	Q96HE9
PVLELPGPSATPVPE	SON	401	P18583
STPVPELPGPPATAV	SON	421	P18583
PATAVPELPGPSVTP	SON	431	P18583
SRPLEESPLSPPPEE	KMT2D	486	O14686
PFSPLEESPLSPPEE	KMT2D	511	O14686
SEPGEPPLSPLPEEL	KMT2D	901	O14686
LPEELPLSPSGEPSL	KMT2D	911	O14686
ASPPTEPLVELPTEP	KMT2D	4926	O14686