Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

HSPG2 EFEMP2 EFHB F12 EYS THBS3 FBLN2 FBN1 CELSR3 CELSR2 PLCH2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

5.27e-077499616GO:0005509
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

EFEMP2 FBLN2 FBN1

2.30e-0512963GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

EFEMP2 FBLN2 FBN1

3.77e-0514963GO:0097493
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF384 ZNF142 ZNF366 ZNF689 ZNF316 ZFP57 SIM1 ZNF784 ZBTB7B ZNF835 CRY1 BCL6B GFI1B ZNF605 ZNF296 ZNF358 TBXT ZNF574 ZNF513

5.67e-0514599619GO:0000977
GeneOntologyMolecularFunctionsulfuric ester hydrolase activity

SGSH STS ARSD

6.97e-0517963GO:0008484
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZNF384 ZNF366 ZNF689 ZNF316 ZNF784 ZBTB7B ZNF835 CRY1 BCL6B GFI1B ZNF605 ZNF296 ZNF358 TBXT NOTCH1 ZNF574 ZNF513

1.07e-0412719617GO:0000987
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZNF384 ZNF366 ZNF689 ZNF316 ZNF784 ZBTB7B ZNF835 CRY1 BCL6B GFI1B ZNF605 ZNF296 ZNF358 TBXT ZNF574 ZNF513

2.74e-0412449616GO:0000978
GeneOntologyMolecularFunctionextracellular matrix structural constituent

HSPG2 EFEMP2 THBS3 FBLN2 FBN1 FBN3

2.95e-04188966GO:0005201
GeneOntologyMolecularFunctionheparin binding

HBEGF EFEMP2 ADA2 BMP4 THBS3 FBN1

3.31e-04192966GO:0008201
GeneOntologyMolecularFunctionmRNA 3'-UTR AU-rich region binding

ZFP36 ZFP36L1 ZFP36L2

3.59e-0429963GO:0035925
GeneOntologyMolecularFunctionsulfur compound binding

HBEGF EFEMP2 ADA2 BMP4 THBS3 FBN1 LRP1

9.46e-04323967GO:1901681
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF384 ZNF142 ZNF689 ZNF316 ZFP57 SIM1 ZNF784 ZBTB7B BCL6B GFI1B ZNF605 ZNF358 TBXT NOTCH1 ZNF574 ZNF513

1.09e-0314129616GO:0000981
GeneOntologyMolecularFunctionBMP receptor binding

BMP2 BMP4

1.72e-0313962GO:0070700
GeneOntologyMolecularFunctionco-receptor binding

BMP2 BMP4

1.72e-0313962GO:0039706
GeneOntologyMolecularFunctionglycosaminoglycan binding

HBEGF EFEMP2 ADA2 BMP4 THBS3 FBN1

1.87e-03268966GO:0005539
GeneOntologyMolecularFunctionarylsulfatase activity

STS ARSD

2.00e-0314962GO:0004065
GeneOntologyBiologicalProcesscellular response to transforming growth factor beta stimulus

DAND5 VASN USP9Y ZYX BMP2 FBN1 ZFP36L1 ZFP36L2 LRP1 LTBP3

3.10e-063369410GO:0071560
GeneOntologyBiologicalProcessresponse to transforming growth factor beta

DAND5 VASN USP9Y ZYX BMP2 FBN1 ZFP36L1 ZFP36L2 LRP1 LTBP3

3.72e-063439410GO:0071559
GeneOntologyBiologicalProcessregulation of epidermal cell differentiation

ZFP36 BMP4 ZFP36L1 PTCH2 NOTCH1

1.01e-0563945GO:0045604
GeneOntologyBiologicalProcessregulation of epidermis development

ZFP36 BMP4 ZFP36L1 PTCH2 NOTCH1

1.81e-0571945GO:0045682
GeneOntologyBiologicalProcesspositive regulation of smooth muscle cell-matrix adhesion

PCSK5 EFEMP2

2.05e-052942GO:1905609
GeneOntologyBiologicalProcessbone morphogenesis

HSPG2 BMP4 THBS3 TBXT LTBP3 GNAS

2.21e-05124946GO:0060349
GeneOntologyBiologicalProcessbone development

HSPG2 BMP2 BMP4 THBS3 FBN1 TBXT LTBP3 GNAS

2.79e-05264948GO:0060348
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

DAND5 VASN USP9Y ZYX ZFP36 EPN2 BMP2 BMP4 FBN1 ZFP36L1 ZFP36L2 LRP1 LTBP3 NOTCH1

2.98e-058509414GO:0071363
GeneOntologyBiologicalProcesscellular response to corticosteroid stimulus

ZFP36 BMP4 ZFP36L1 ZFP36L2 SCNN1D

3.44e-0581945GO:0071384
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

DAND5 VASN USP9Y ZYX BMP2 BMP4 FBN1 LRP1 LTBP3 NOTCH1

3.55e-054459410GO:0141091
GeneOntologyBiologicalProcesstransforming growth factor beta receptor signaling pathway

DAND5 VASN USP9Y ZYX BMP2 FBN1 LRP1 LTBP3

3.83e-05276948GO:0007179
GeneOntologyBiologicalProcessresponse to growth factor

DAND5 VASN USP9Y ZYX ZFP36 EPN2 BMP2 BMP4 FBN1 ZFP36L1 ZFP36L2 LRP1 LTBP3 NOTCH1

4.51e-058839414GO:0070848
GeneOntologyBiologicalProcesspositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

ZFP36 ZFP36L1 ZFP36L2

4.92e-0516943GO:1900153
GeneOntologyBiologicalProcesspositive regulation of intracellular mRNA localization

ZFP36 ZFP36L1

6.15e-053942GO:1904582
GeneOntologyBiologicalProcessluteolysis

CASP2 NOTCH1

6.15e-053942GO:0001554
GeneOntologyBiologicalProcessartery morphogenesis

EFEMP2 BMP4 LRP1 NOTCH1 NOTCH3

6.35e-0592945GO:0048844
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

DAND5 VASN USP9Y ZYX BMP2 BMP4 FBN1 LRP1 LTBP3 NOTCH1

6.92e-054829410GO:0007178
GeneOntologyBiologicalProcess3'-UTR-mediated mRNA destabilization

ZFP36 ZFP36L1 ZFP36L2

8.42e-0519943GO:0061158
GeneOntologyBiologicalProcessmulticellular organismal reproductive process

DNHD1 SPATA31A3 SPATA31A7 ZFP57 SPATA31C2 CASP2 USP9Y SPATA31C1 SPATA31A5 BPY2 BMP4 SPATA31A1 ZNF296 TBXT GNAS NOTCH1

9.17e-0511949416GO:0048609
GeneOntologyBiologicalProcesscellular response to steroid hormone stimulus

ZNF366 ZFP36 CRY1 BMP4 ZFP36L1 ZFP36L2 SCNN1D

1.12e-04239947GO:0071383
GeneOntologyBiologicalProcessregulation of fat cell differentiation

ZBTB7B ZFP36 BMP2 FBN1 ZFP36L1 ZFP36L2

1.20e-04168946GO:0045598
GeneOntologyBiologicalProcessgamete generation

DNHD1 SPATA31A3 SPATA31A7 ZFP57 SPATA31C2 USP9Y SPATA31C1 SPATA31A5 BPY2 BMP4 SPATA31A1 ZNF296 GNAS NOTCH1

1.40e-049829414GO:0007276
GeneOntologyBiologicalProcesstube development

PCSK5 HSPG2 HBEGF EFEMP2 SIM1 EPN2 FZD6 BMP2 BMP4 FBN1 ZFP36L1 ZNF358 LRP1 TBXT LTBP3 NOTCH1 NOTCH3

1.81e-0414029417GO:0035295
GeneOntologyBiologicalProcessappendage morphogenesis

PCSK5 FZD6 BMP4 ZNF358 GNAS NOTCH1

2.03e-04185946GO:0035107
GeneOntologyBiologicalProcesslimb morphogenesis

PCSK5 FZD6 BMP4 ZNF358 GNAS NOTCH1

2.03e-04185946GO:0035108
GeneOntologyBiologicalProcesssequestering of BMP in extracellular matrix

DAND5 FBN1

2.04e-045942GO:0035582
GeneOntologyBiologicalProcessregulation of smooth muscle cell-matrix adhesion

PCSK5 EFEMP2

2.04e-045942GO:2000097
GeneOntologyBiologicalProcessregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

ZFP36 ZFP36L1 ZFP36L2

2.48e-0427943GO:1900151
GeneOntologyBiologicalProcessp38MAPK cascade

ZFP36 BMP2 BMP4 ZFP36L1

2.49e-0467944GO:0038066
GeneOntologyBiologicalProcesscellular response to glucocorticoid stimulus

ZFP36 BMP4 ZFP36L1 ZFP36L2

2.64e-0468944GO:0071385
GeneOntologyBiologicalProcesssexual reproduction

DNHD1 SPATA31A3 SPATA31A7 ZFP57 SPATA31C2 USP9Y SPATA31C1 SPATA31A5 BPY2 BMP4 SPATA31A1 ZNF296 ANAPC1 TBXT GNAS NOTCH1

2.70e-0413129416GO:0019953
GeneOntologyBiologicalProcesspositive regulation of epidermal cell differentiation

BMP4 PTCH2 NOTCH1

2.76e-0428943GO:0045606
GeneOntologyBiologicalProcessBMP signaling pathway

DAND5 USP9Y BMP2 BMP4 FBN1 NOTCH1

2.85e-04197946GO:0030509
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

DAND5 VASN HBEGF USP9Y ZBTB7B RNF126 ZYX GFRA3 EPN2 BMP2 BMP4 FBN1 LRP1 LTBP3 NOTCH1

2.92e-0411869415GO:0007167
GeneOntologyBiologicalProcessglomerulus vasculature morphogenesis

BMP4 NOTCH3

3.05e-046942GO:0072103
GeneOntologyBiologicalProcessglomerular capillary formation

BMP4 NOTCH3

3.05e-046942GO:0072104
GeneOntologyBiologicalProcesscardiac jelly development

BMP2 BMP4

3.05e-046942GO:1905072
GeneOntologyBiologicalProcessepidermal cell fate specification

PTCH2 NOTCH1

3.05e-046942GO:0009957
GeneOntologyBiologicalProcessregulation of intracellular mRNA localization

ZFP36 ZFP36L1

3.05e-046942GO:1904580
GeneOntologyBiologicalProcessneural tube development

FZD6 BMP4 ZFP36L1 ZNF358 TBXT NOTCH1

3.26e-04202946GO:0021915
GeneOntologyBiologicalProcessglomerulus vasculature development

BMP4 NOTCH1 NOTCH3

3.40e-0430943GO:0072012
GeneOntologyBiologicalProcessartery development

EFEMP2 BMP4 LRP1 NOTCH1 NOTCH3

3.58e-04133945GO:0060840
GeneOntologyBiologicalProcesscardiac septum development

PCSK5 DAND5 BMP4 LRP1 NOTCH1

3.71e-04134945GO:0003279
GeneOntologyBiologicalProcesskidney vasculature development

BMP4 NOTCH1 NOTCH3

3.76e-0431943GO:0061440
GeneOntologyBiologicalProcessrenal system vasculature development

BMP4 NOTCH1 NOTCH3

3.76e-0431943GO:0061437
GeneOntologyBiologicalProcessnegative regulation of developmental process

HSPG2 VASN ZBTB7B ZFP36 EPN2 BMP2 BMP4 FBN1 ZNF296 ZFP36L1 ZFP36L2 LTBP3 GNAS NOTCH1 NOTCH3

3.94e-0412209415GO:0051093
GeneOntologyBiologicalProcessendocardial cushion formation

BMP2 BMP4 NOTCH1

4.13e-0432943GO:0003272
GeneOntologyBiologicalProcesscardiac chamber development

PCSK5 DAND5 BMP2 BMP4 LRP1 NOTCH1

4.22e-04212946GO:0003205
GeneOntologyBiologicalProcessnegative regulation of transforming growth factor beta receptor signaling pathway

DAND5 VASN BMP2 FBN1 LRP1

4.25e-04138945GO:0030512
GeneOntologyBiologicalProcessrenal system vasculature morphogenesis

BMP4 NOTCH3

4.25e-047942GO:0061438
GeneOntologyBiologicalProcesskidney vasculature morphogenesis

BMP4 NOTCH3

4.25e-047942GO:0061439
GeneOntologyBiologicalProcessDNA replication, synthesis of primer

POLRMT PRIM2

4.25e-047942GO:0006269
GeneOntologyBiologicalProcesspositive regulation of odontoblast differentiation

BMP2 BMP4

4.25e-047942GO:1901331
GeneOntologyBiologicalProcesssmooth muscle cell-matrix adhesion

PCSK5 EFEMP2

4.25e-047942GO:0061302
GeneOntologyBiologicalProcessnuclear-transcribed mRNA catabolic process, deadenylation-independent decay

ZFP36 ZFP36L1

4.25e-047942GO:0031086
GeneOntologyBiologicalProcessdevelopmental process involved in reproduction

DNHD1 SPATA31A3 SPATA31A7 ZFP57 SPATA31C2 CASP2 USP9Y SPATA31C1 SPATA31A5 BPY2 BMP4 SPATA31A1 ZNF296 GNAS NOTCH1

4.48e-0412359415GO:0003006
GeneOntologyBiologicalProcesspositive regulation of epidermis development

BMP4 PTCH2 NOTCH1

4.53e-0433943GO:0045684
GeneOntologyBiologicalProcessnegative regulation of stem cell differentiation

ZFP36 ZFP36L2 NOTCH1

4.53e-0433943GO:2000737
GeneOntologyBiologicalProcessresponse to BMP

DAND5 USP9Y BMP2 BMP4 FBN1 NOTCH1

4.54e-04215946GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

DAND5 USP9Y BMP2 BMP4 FBN1 NOTCH1

4.54e-04215946GO:0071773
GeneOntologyBiologicalProcesscellular response to hormone stimulus

ZNF366 ZBTB7B ZFP36 CRY1 BMP4 FBN1 ZFP36L1 ZFP36L2 SCNN1D GNAS NOTCH1

4.68e-047279411GO:0032870
GeneOntologyBiologicalProcessendochondral bone morphogenesis

HSPG2 BMP4 THBS3 GNAS

4.68e-0479944GO:0060350
GeneOntologyBiologicalProcesspositive regulation of fat cell differentiation

ZBTB7B ZFP36 BMP2 ZFP36L1

4.68e-0479944GO:0045600
GeneOntologyBiologicalProcessregulation of epithelial cell differentiation

ZFP36 BMP2 BMP4 ZFP36L1 PTCH2 NOTCH1

4.77e-04217946GO:0030856
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

DAND5 VASN BMP2 FBN1 LRP1 NOTCH1

4.89e-04218946GO:0090101
GeneOntologyBiologicalProcesspositive regulation of epithelial cell differentiation

BMP2 BMP4 PTCH2 NOTCH1

5.39e-0482944GO:0030858
GeneOntologyBiologicalProcessembryonic hindlimb morphogenesis

BMP4 GNAS NOTCH1

5.40e-0435943GO:0035116
GeneOntologyBiologicalProcesslimb development

PCSK5 FZD6 BMP4 ZNF358 GNAS NOTCH1

5.64e-04224946GO:0060173
GeneOntologyBiologicalProcessappendage development

PCSK5 FZD6 BMP4 ZNF358 GNAS NOTCH1

5.64e-04224946GO:0048736
GeneOntologyBiologicalProcesscoronary vasculature development

PCSK5 BMP4 LRP1 NOTCH1

5.65e-0483944GO:0060976
GeneOntologyBiologicalProcessheart induction

BMP2 BMP4

5.65e-048942GO:0003129
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

DAND5 FBN1

5.65e-048942GO:0071694
GeneOntologyBiologicalProcesspositive regulation of neuroepithelial cell differentiation

BMP2 BMP4

5.65e-048942GO:1902913
GeneOntologyBiologicalProcesspositive regulation of mesenchymal stem cell proliferation

BMP4 LTBP3

5.65e-048942GO:1902462
GeneOntologyBiologicalProcessspermatogenesis

DNHD1 SPATA31A3 SPATA31A7 SPATA31C2 USP9Y SPATA31C1 SPATA31A5 BPY2 SPATA31A1 ZNF296 NOTCH1

5.67e-047449411GO:0007283
GeneOntologyBiologicalProcessembryonic limb morphogenesis

FZD6 BMP4 ZNF358 GNAS NOTCH1

5.84e-04148945GO:0030326
GeneOntologyBiologicalProcessembryonic appendage morphogenesis

FZD6 BMP4 ZNF358 GNAS NOTCH1

5.84e-04148945GO:0035113
GeneOntologyBiologicalProcessembryonic skeletal system development

PCSK5 HSPG2 BMP4 TBXT GNAS

5.84e-04148945GO:0048706
GeneOntologyBiologicalProcessheart formation

BMP2 BMP4 NOTCH1

5.87e-0436943GO:0060914
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

DAND5 VASN EPN2 BMP2 BMP4 FBN1 LRP1 NOTCH1

5.90e-04412948GO:0090287
GeneOntologyBiologicalProcessregulation of extracellular matrix organization

EFEMP2 BMP2 LRP1 NOTCH1

5.91e-0484944GO:1903053
GeneOntologyBiologicalProcessmale gamete generation

DNHD1 SPATA31A3 SPATA31A7 SPATA31C2 USP9Y SPATA31C1 SPATA31A5 BPY2 SPATA31A1 ZNF296 NOTCH1

6.91e-047629411GO:0048232
GeneOntologyBiologicalProcessregulation of keratinocyte apoptotic process

ZFP36 ZFP36L1

7.25e-049942GO:1902172
GeneOntologyBiologicalProcessregulation of heart morphogenesis

BMP2 BMP4

7.25e-049942GO:2000826
GeneOntologyBiologicalProcesskeratinocyte apoptotic process

ZFP36 ZFP36L1

7.25e-049942GO:0097283
GeneOntologyBiologicalProcessameloblast differentiation

BMP2 BMP4

7.25e-049942GO:0036305
GeneOntologyBiologicalProcessregulation of postsynaptic neurotransmitter receptor internalization

SUSD4 LRP1 RNF216

7.44e-0439943GO:0099149
GeneOntologyBiologicalProcesscardiac epithelial to mesenchymal transition

BMP2 BMP4 NOTCH1

8.01e-0440943GO:0060317
GeneOntologyBiologicalProcessregulation of keratinocyte differentiation

ZFP36 ZFP36L1 NOTCH1

8.01e-0440943GO:0045616
GeneOntologyBiologicalProcesschordate embryonic development

PCSK5 HSPG2 HBEGF EPN2 FZD6 BMP2 BMP4 ZFP36L1 ZNF358 TBXT GNAS NOTCH1

8.33e-049069412GO:0043009
GeneOntologyBiologicalProcessaorta morphogenesis

EFEMP2 LRP1 NOTCH1

8.62e-0441943GO:0035909
GeneOntologyBiologicalProcesscartilage development

HSPG2 BMP2 BMP4 THBS3 LTBP3 GNAS

8.62e-04243946GO:0051216
GeneOntologyBiologicalProcessmuscle tissue morphogenesis

EFEMP2 BMP2 BMP4 NOTCH1

8.66e-0493944GO:0060415
GeneOntologyBiologicalProcesscellular response to granulocyte macrophage colony-stimulating factor stimulus

ZFP36 ZFP36L2

9.03e-0410942GO:0097011
GeneOntologyBiologicalProcesspericyte cell differentiation

BMP4 NOTCH1

9.03e-0410942GO:1904238
GeneOntologyBiologicalProcessregulation of extracellular matrix constituent secretion

BMP2 NOTCH1

9.03e-0410942GO:0003330
GeneOntologyBiologicalProcesscardiac atrium development

DAND5 BMP2 NOTCH1

9.25e-0442943GO:0003230
GeneOntologyBiologicalProcessanterior/posterior pattern specification

PCSK5 BMP2 BMP4 CELSR2 TBXT NOTCH1

9.38e-04247946GO:0009952
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

ZNF366 ZFP57 ZBTB7B ZFP36 CRY1 BCL6B GFI1B BMP2 BMP4 ZNF296 TBXT NOTCH1 NOTCH3

9.59e-0410539413GO:0000122
GeneOntologyBiologicalProcessconnective tissue development

HSPG2 BMP2 BMP4 THBS3 LTBP3 GNAS NOTCH1

9.82e-04343947GO:0061448
GeneOntologyCellularComponentmicrofibril

EFEMP2 FBN1 FBN3

2.68e-0513973GO:0001527
GeneOntologyCellularComponentextracellular matrix

HSPG2 VASN EFEMP2 F12 EYS THBS3 FBLN2 FBN1 FCGBP LTBP3 FBN3

2.30e-046569711GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

HSPG2 VASN EFEMP2 F12 EYS THBS3 FBLN2 FBN1 FCGBP LTBP3 FBN3

2.36e-046589711GO:0030312
GeneOntologyCellularComponentacrosomal vesicle

SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5 SPATA31A1 NOTCH1

4.00e-04206976GO:0001669
HumanPhenoAbnormal 5th metacarpal morphology

BMP2 FBN1 LTBP3 GNAS

1.75e-0522384HP:0010013
HumanPhenoAzoospermia

DNHD1 HSPG2 SGSH EFEMP2 SIM1 USP9Y BPY2 PIGQ BMP2 BMP4 EYS FBN1 STS ANAPC1 PTCH2 GNAS POMK NOTCH1 NOTCH3 ZNF513

5.36e-0511573820HP:0000027
HumanPhenoFifth metacarpal with ulnar notch

FBN1 LTBP3

5.42e-052382HP:0005900
HumanPhenoAbnormal spermatogenesis

DNHD1 HSPG2 SGSH EFEMP2 SIM1 USP9Y BPY2 PIGQ BMP2 BMP4 EYS FBN1 STS ANAPC1 PTCH2 GNAS POMK NOTCH1 NOTCH3 ZNF513

8.21e-0511903820HP:0008669
HumanPhenoFull cheeks

HSPG2 SIM1 PIGQ BMP2 FBN1 LTBP3 GNAS

1.02e-04151387HP:0000293
HumanPhenoProtrusio acetabuli

HSPG2 BMP4 FBN1

1.04e-0413383HP:0003179
HumanPhenoAbnormal testis morphology

DNHD1 HSPG2 SGSH EFEMP2 SIM1 USP9Y PIGQ BMP2 BMP4 EYS FBN1 STS ANAPC1 PTCH2 GNAS POMK NOTCH1 NOTCH3 ZNF513

1.42e-0411293819HP:0000035
HumanPhenoNon-obstructive azoospermia

DNHD1 HSPG2 SGSH EFEMP2 SIM1 USP9Y PIGQ BMP2 BMP4 EYS FBN1 STS ANAPC1 PTCH2 GNAS POMK NOTCH1 NOTCH3 ZNF513

1.48e-0411323819HP:0011961
HumanPhenoAbnormal male internal genitalia morphology

DNHD1 HSPG2 SGSH EFEMP2 SIM1 USP9Y BPY2 PIGQ BMP2 BMP4 EYS FBN1 STS ANAPC1 PTCH2 GNAS POMK NOTCH1 NOTCH3 ZNF513

1.57e-0412433820HP:0000022
HumanPhenoAbnormal cheek morphology

HSPG2 EFEMP2 SIM1 PIGQ BMP2 FBN1 LRP1 LTBP3 GNAS

1.69e-04282389HP:0004426
HumanPhenoFunctional abnormality of male internal genitalia

DNHD1 HSPG2 SGSH EFEMP2 SIM1 USP9Y BPY2 PIGQ BMP2 BMP4 EYS FBN1 STS ANAPC1 PTCH2 GNAS POMK NOTCH1 NOTCH3 ZNF513

2.13e-0412693820HP:0000025
MousePhenoabnormal heart development

HSPG2 DAND5 HBEGF PIGQ BMP2 BMP4 ZFP36L1 TBXT ADGRL2 NOTCH1

1.01e-053726710MP:0000267
MousePhenoabnormal artery morphology

PCSK5 HSPG2 HBEGF EFEMP2 BMP4 FBN1 ZFP36L1 TBXT NOTCH1 NOTCH3

4.29e-054406710MP:0002191
DomainEGF

PCSK5 HGFAC HSPG2 VASN HBEGF EFEMP2 F12 EYS THBS3 FBLN2 FBN1 FCGBP CELSR3 CELSR2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

4.76e-182359319SM00181
DomainEGF-like_dom

PCSK5 HGFAC HSPG2 VASN HBEGF EFEMP2 F12 EYS THBS3 FBLN2 FBN1 FCGBP CELSR3 CELSR2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

1.41e-172499319IPR000742
DomainEGF_CA

HSPG2 EFEMP2 F12 EYS THBS3 FBLN2 FBN1 CELSR3 CELSR2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

1.15e-151229314SM00179
DomainEGF-like_Ca-bd_dom

HSPG2 EFEMP2 F12 EYS THBS3 FBLN2 FBN1 CELSR3 CELSR2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

1.45e-151249314IPR001881
DomainEGF_3

HGFAC HSPG2 VASN HBEGF EFEMP2 F12 EYS THBS3 FBLN2 FBN1 CELSR3 CELSR2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

2.05e-152359317PS50026
DomainEGF_1

HGFAC HSPG2 VASN HBEGF EFEMP2 F12 EYS THBS3 FBLN2 FBN1 CELSR3 CELSR2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

7.98e-152559317PS00022
DomainEGF-like_CS

HGFAC HSPG2 VASN HBEGF EFEMP2 F12 EYS THBS3 FBLN2 FBN1 CELSR3 CELSR2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

1.17e-142619317IPR013032
DomainEGF_2

HGFAC HSPG2 VASN HBEGF EFEMP2 F12 EYS THBS3 FBLN2 FBN1 CELSR3 CELSR2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

1.51e-142659317PS01186
DomainGrowth_fac_rcpt_

PCSK5 HSPG2 EFEMP2 EYS THBS3 FBLN2 FBN1 CELSR2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

8.48e-131569313IPR009030
DomainEGF

HGFAC HSPG2 VASN HBEGF F12 EYS CELSR3 CELSR2 LRP1 FBN3 NOTCH1 NOTCH3

1.37e-121269312PF00008
DomainASX_HYDROXYL

EFEMP2 EYS FBLN2 FBN1 CELSR3 CELSR2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

2.50e-121009311PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

EFEMP2 EYS FBLN2 FBN1 CELSR3 CELSR2 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

4.79e-121069311IPR000152
DomainEGF_Ca-bd_CS

EFEMP2 EYS THBS3 FBLN2 FBN1 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

5.03e-11979310IPR018097
DomainEGF_CA

EFEMP2 EYS THBS3 FBLN2 FBN1 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

6.18e-11999310PS01187
DomainEGF_CA

EFEMP2 THBS3 FBLN2 FBN1 LRP1 LTBP3 FBN3 NOTCH1 NOTCH3

4.25e-1086939PF07645
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31C2 SPATA31C1 SPATA31A5

2.12e-0912935PF15371
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31C2 SPATA31C1 SPATA31A5

2.12e-0912935IPR027970
DomaincEGF

EFEMP2 FBLN2 FBN1 LRP1 LTBP3 FBN3

2.75e-0926936IPR026823
DomaincEGF

EFEMP2 FBLN2 FBN1 LRP1 LTBP3 FBN3

2.75e-0926936PF12662
DomainhEGF

EYS CELSR2 LTBP3 FBN3 NOTCH1 NOTCH3

4.46e-0928936PF12661
Domain-

ZNF384 ZNF142 ZNF366 ZNF689 ZNF316 ZFP57 ZNF784 ZBTB7B ZNF835 BCL6B GFI1B ZNF605 ZNF296 ZNF358 ZNF574 ZNF513

2.19e-0767993163.30.160.60
Domainzf-C2H2

ZNF384 ZNF142 ZNF366 ZNF689 ZNF316 ZFP57 ZNF784 ZBTB7B ZNF835 BCL6B GFI1B ZNF605 ZNF296 ZNF358 ZNF574 ZNF513

2.89e-076939316PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF384 ZNF142 ZNF366 ZNF689 ZNF316 ZFP57 ZNF784 ZBTB7B ZNF835 BCL6B GFI1B ZNF605 ZNF296 ZNF358 ZNF574 ZNF513

2.94e-076949316IPR013087
DomainZINC_FINGER_C2H2_2

ZNF384 ZNF142 ZNF366 ZNF689 ZNF316 ZFP57 ZNF784 ZBTB7B ZNF835 BCL6B GFI1B ZNF605 ZNF296 ZNF358 ZNF574 ZNF513

1.27e-067759316PS50157
DomainZINC_FINGER_C2H2_1

ZNF384 ZNF142 ZNF366 ZNF689 ZNF316 ZFP57 ZNF784 ZBTB7B ZNF835 BCL6B GFI1B ZNF605 ZNF296 ZNF358 ZNF574 ZNF513

1.31e-067779316PS00028
DomainZnf_C2H2-like

ZNF384 ZNF142 ZNF366 ZNF689 ZNF316 ZFP57 ZNF784 ZBTB7B ZNF835 BCL6B GFI1B ZNF605 ZNF296 ZNF358 ZNF574 ZNF513

1.80e-067969316IPR015880
DomainZnf_C2H2

ZNF384 ZNF142 ZNF366 ZNF689 ZNF316 ZFP57 ZNF784 ZBTB7B ZNF835 BCL6B GFI1B ZNF605 ZNF296 ZNF358 ZNF574 ZNF513

2.08e-068059316IPR007087
DomainZnF_C2H2

ZNF384 ZNF142 ZNF366 ZNF689 ZNF316 ZFP57 ZNF784 ZBTB7B ZNF835 BCL6B GFI1B ZNF605 ZNF296 ZNF358 ZNF574 ZNF513

2.18e-068089316SM00355
DomainTB

FBN1 LTBP3 FBN3

4.12e-067933PF00683
Domain-

FBN1 LTBP3 FBN3

6.57e-0689333.90.290.10
DomainTB

FBN1 LTBP3 FBN3

9.82e-069933PS51364
DomainTB_dom

FBN1 LTBP3 FBN3

9.82e-069933IPR017878
DomainLaminin_G

HSPG2 EYS THBS3 CELSR3 CELSR2

1.02e-0558935IPR001791
DomainGAIN_dom_N

CELSR3 CELSR2 ADGRL2

1.92e-0511933IPR032471
DomainGAIN

CELSR3 CELSR2 ADGRL2

1.92e-0511933PF16489
DomainTis11B_N

ZFP36L1 ZFP36L2

2.45e-052932PF04553
DomainTis11B_N

ZFP36L1 ZFP36L2

2.45e-052932IPR007635
DomainCoagulation_fac_XIIa/HGFA

HGFAC F12

2.45e-052932IPR014394
DomainLAM_G_DOMAIN

HSPG2 EYS CELSR3 CELSR2

3.74e-0538934PS50025
DomainLaminin_G_2

HSPG2 EYS CELSR3 CELSR2

4.59e-0540934PF02210
DomainSulfatase_CS

SGSH STS ARSD

6.39e-0516933IPR024607
DomainLamG

HSPG2 EYS CELSR3 CELSR2

6.71e-0544934SM00282
DomainDUF3454

NOTCH1 NOTCH3

7.33e-053932PF11936
DomainDUF3454_notch

NOTCH1 NOTCH3

7.33e-053932IPR024600
DomainDUF3454

NOTCH1 NOTCH3

7.33e-053932SM01334
DomainFBN

FBN1 FBN3

7.33e-053932IPR011398
DomainSULFATASE_1

SGSH STS ARSD

7.73e-0517933PS00523
DomainSULFATASE_2

SGSH STS ARSD

7.73e-0517933PS00149
DomainSulfatase

SGSH STS ARSD

9.24e-0518933PF00884
DomainSulfatase_N

SGSH STS ARSD

9.24e-0518933IPR000917
DomainZnF_C3H1

ZC3H14 ZFP36 ZFP36L1 ZFP36L2

9.48e-0548934SM00356
Domain-

HSPG2 EYS THBS3 CELSR3 CELSR2

1.12e-04959352.60.120.200
DomainFN1_2

HGFAC F12

1.46e-044932PS51091
DomainNotch

NOTCH1 NOTCH3

1.46e-044932IPR008297
DomainNODP

NOTCH1 NOTCH3

1.46e-044932PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH3

1.46e-044932IPR011656
DomainNotch_NOD_dom

NOTCH1 NOTCH3

1.46e-044932IPR010660
DomainNOD

NOTCH1 NOTCH3

1.46e-044932PF06816
Domainfn1

HGFAC F12

1.46e-044932PF00039
DomainFibronectin_type1

HGFAC F12

1.46e-044932IPR000083
DomainFN1

HGFAC F12

1.46e-044932SM00058
DomainNOD

NOTCH1 NOTCH3

1.46e-044932SM01338
DomainNODP

NOTCH1 NOTCH3

1.46e-044932SM01339
DomainFN1_1

HGFAC F12

1.46e-044932PS01253
DomainZnf_CCCH

ZC3H14 ZFP36 ZFP36L1 ZFP36L2

1.99e-0458934IPR000571
DomainZF_C3H1

ZC3H14 ZFP36 ZFP36L1 ZFP36L2

1.99e-0458934PS50103
DomainGPCR_2_secretin-like

FZD6 CELSR3 CELSR2 ADGRL2

2.27e-0460934IPR000832
DomainGPCR_2-like

FZD6 CELSR3 CELSR2 ADGRL2

2.27e-0460934IPR017981
DomainG_PROTEIN_RECEP_F2_4

FZD6 CELSR3 CELSR2 ADGRL2

2.42e-0461934PS50261
DomainLNR

NOTCH1 NOTCH3

2.43e-045932PS50258
DomainHormR

CELSR3 CELSR2 ADGRL2

2.54e-0425933SM00008
DomainHRM

CELSR3 CELSR2 ADGRL2

3.58e-0428933PF02793
DomainEGF_LAM_2

HSPG2 CELSR3 CELSR2

4.40e-0430933PS50027
DomainEGF_LAM_1

HSPG2 CELSR3 CELSR2

4.40e-0430933PS01248
DomainAlkaline_phosphatase_core

SGSH STS ARSD

4.86e-0431933IPR017850
DomainAlkaline_Pase-like_a/b/a

SGSH STS ARSD

4.86e-0431933IPR017849
Domain-

SGSH STS ARSD

4.86e-04319333.40.720.10
DomainNotch_dom

NOTCH1 NOTCH3

5.07e-047932IPR000800
DomainNotch

NOTCH1 NOTCH3

5.07e-047932PF00066
DomainNL

NOTCH1 NOTCH3

5.07e-047932SM00004
DomainGPS

CELSR3 CELSR2 ADGRL2

6.40e-0434933SM00303
DomainGPS

CELSR3 CELSR2 ADGRL2

6.97e-0435933PF01825
DomainLaminin_EGF

HSPG2 CELSR3 CELSR2

6.97e-0435933PF00053
DomainEGF_Lam

HSPG2 CELSR3 CELSR2

6.97e-0435933SM00180
DomainGPS

CELSR3 CELSR2 ADGRL2

7.58e-0436933PS50221
DomainGPS

CELSR3 CELSR2 ADGRL2

8.21e-0437933IPR000203
DomainLaminin_EGF

HSPG2 CELSR3 CELSR2

8.89e-0438933IPR002049
Domainzf-C2H2_6

ZNF384 ZNF366 ZNF316 GFI1B ZNF605 ZNF358 ZNF574

9.78e-04314937PF13912
DomainG_PROTEIN_RECEP_F2_1

CELSR3 CELSR2 ADGRL2

1.03e-0340933PS00649
DomainGPCR_2_extracellular_dom

CELSR3 CELSR2 ADGRL2

1.03e-0340933IPR001879
Domain-

ZFP36 ZFP36L1 ZFP36L2

1.03e-03409334.10.1000.10
DomainG_PROTEIN_RECEP_F2_3

CELSR3 CELSR2 ADGRL2

1.03e-0340933PS50227
DomainLaminin_G_1

HSPG2 EYS

1.31e-0311932PF00054
Domain-

HGFAC F12

1.85e-03139322.10.10.10
Domainzf-CCCH

ZFP36 ZFP36L1 ZFP36L2

1.87e-0349933PF00642
DomainG_PROTEIN_RECEP_F2_2

CELSR3 CELSR2 ADGRL2

1.98e-0350933PS00650
Domain7tm_2

CELSR3 CELSR2 ADGRL2

1.98e-0350933PF00002
DomainFN_type2_col-bd

HGFAC F12

2.15e-0314932IPR000562
DomainFN2_2

HGFAC F12

2.15e-0314932PS51092
DomainIBR

CUL9 RNF216

2.15e-0314932SM00647
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

EFEMP2 BMP2 BMP4 FBLN2 FBN1 LTBP3 FBN3

3.65e-1037677M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

EFEMP2 BMP2 BMP4 FBLN2 FBN1 LTBP3 FBN3

1.32e-0944677M26969
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

EFEMP2 BMP2 BMP4 FBLN2 FBN1 LTBP3

7.54e-0932676MM14854
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

EFEMP2 BMP2 BMP4 FBLN2 FBN1 LTBP3

2.65e-0839676MM14601
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

HSPG2 EFEMP2 BMP2 BMP4 FBLN2 FBN1 LTBP3 FBN3

8.40e-05300678M610
PathwayKEGG_BASAL_CELL_CARCINOMA

FZD6 BMP2 BMP4 PTCH2

1.32e-0455674M17807
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH1 NOTCH3

2.20e-045672M27411
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH3

2.20e-045672MM14733
PathwayWP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES

FZD6 BMP2 BMP4 NOTCH1 NOTCH3

2.41e-04118675M39852
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH1 NOTCH3

3.30e-046672M27068
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY

BMP2 BMP4 PTCH2

3.43e-0429673M47372
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY

BMP2 BMP4 PTCH2

3.43e-0429673M47377
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

NOTCH1 NOTCH3

4.60e-047672MM14734
PathwayWP_CLOCKCONTROLLED_AUTOPHAGY_IN_BONE_METABOLISM

CRY1 BMP2 BMP4 NOTCH1

5.62e-0480674M45523
PathwayKEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA

FBN1 LTBP3

6.12e-048672M47850
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5 SPATA31A1

9.59e-13698520850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5 SPATA31A1

9.59e-13698525930072
Pubmed

Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism.

HBEGF ZFP36 ZFP36L1 ZFP36L2

2.96e-10598426952984
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

PCSK5 HSPG2 EFEMP2 ITPRID2 FBN1 LRP1 LTBP3 NOTCH1

1.68e-0911898821078624
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A3 SPATA31A7 SPATA31C1 SPATA31A5 SPATA31A1

6.53e-092498532212159
Pubmed

The roles of TTP and BRF proteins in regulated mRNA decay.

ZFP36 ZFP36L1 ZFP36L2

2.17e-08398321278925
Pubmed

Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins.

ZFP36 ZFP36L1 ZFP36L2

2.17e-08398315814898
Pubmed

The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat.

ZFP36 ZFP36L1 ZFP36L2

2.17e-0839831996120
Pubmed

Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins.

ZFP36 ZFP36L1 ZFP36L2

2.17e-08398314604009
Pubmed

ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.

ZFP36 ZFP36L1 ZFP36L2

2.17e-08398334333017
Pubmed

Functional analysis of ZFP36 proteins in keratinocytes.

ZFP36 ZFP36L1 ZFP36L2

2.17e-08398327182009
Pubmed

The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses.

ZFP36 ZFP36L1 ZFP36L2

2.17e-08398336269839
Pubmed

Synergistic roles of tristetraprolin family members in myeloid cells in the control of inflammation.

ZFP36 ZFP36L1 ZFP36L2

8.66e-08498337903626
Pubmed

ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production.

ZFP36 ZFP36L1 ZFP36L2

8.66e-08498320166898
Pubmed

Tooth morphogenesis and the differentiation of ameloblasts.

BMP2 BMP4 NOTCH1

8.66e-0849839189614
Pubmed

Multiple tristetraprolin sequence domains required to induce apoptosis and modulate responses to TNFalpha through distinct pathways.

ZFP36 ZFP36L1 ZFP36L2

8.66e-08498312082611
Pubmed

Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling.

ZFP36 ZFP36L1 ZFP36L2

8.66e-08498311796723
Pubmed

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.

ZFP36 ZFP36L1 ZFP36L2

8.66e-08498325106868
Pubmed

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.

ZFP36 ZFP36L1 ZFP36L2

2.16e-07598322701344
Pubmed

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

BMP2 BMP4 TBXT

2.16e-0759837657163
Pubmed

Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b.

ZFP36 ZFP36L1 ZFP36L2

2.16e-07598315467755
Pubmed

Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins.

ZFP36 ZFP36L1 ZFP36L2

2.16e-07598338157296
Pubmed

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.

ZFP36 ZFP36L1 ZFP36L2

2.16e-07598324733888
Pubmed

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.

SIM1 BMP2 BMP4 TBXT

2.22e-07199849585504
Pubmed

Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1.

ZFP36 ZFP36L1 ZFP36L2

4.31e-07698328394372
Pubmed

Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation.

BMP4 NOTCH1 NOTCH3

4.31e-0769839882480
Pubmed

Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites.

EFEMP2 FBLN2 FBN1

4.31e-07698319349279
Pubmed

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice.

BMP2 BMP4 NOTCH1

7.53e-0779839531541
Pubmed

Murine cerberus homologue mCer-1: a candidate anterior patterning molecule.

BMP2 BMP4 TBXT

7.53e-0779839501024
Pubmed

Targeting of bone morphogenetic protein growth factor complexes to fibrillin.

BMP2 BMP4 FBN1

1.20e-06898318339631
Pubmed

The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis.

BMP2 BMP4 PTCH2

1.80e-06998317397822
Pubmed

SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.

PCSK5 BMP2 BMP4

1.80e-0699838698813
Pubmed

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.

BMP2 BMP4 NOTCH1 NOTCH3

2.58e-063498421311046
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

ZFP57 FZD6 BMP2 BMP4 ZNF296 PTCH2 TBXT NOTCH1 NOTCH3

3.30e-0642498921731673
Pubmed

Myocardial β-Catenin-BMP2 signaling promotes mesenchymal cell proliferation during endocardial cushion formation.

HBEGF BMP2 BMP4 NOTCH1

4.06e-063898430201295
Pubmed

Protein interactome reveals converging molecular pathways among autism disorders.

ZNF384 EFEMP2 ITPRID2 FBLN2 FBN1 GEMIN8 HAGH LTBP3 NOTCH1 NOTCH3

4.26e-06560981021653829
Pubmed

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

HSPG2 EFEMP2 THBS3 FBLN2 FBN1

4.66e-068698528327460
Pubmed

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.

BMP2 BMP4 PTCH2

4.69e-061298311389830
Pubmed

Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.

HSPG2 BMP4 TBXT

4.69e-061298322072575
Pubmed

Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development.

BMP4 NOTCH1 NOTCH3

4.69e-061298332147304
Pubmed

RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects.

BMP2 BMP4 NOTCH1

4.69e-061298330061196
Pubmed

Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb.

FZD6 BMP2 BMP4

6.08e-061398312923052
Pubmed

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice.

BMP2 BMP4 LRP1

6.08e-061398316207730
Pubmed

Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa.

BMP4 NOTCH1 NOTCH3

6.08e-061398321632926
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

HSPG2 VASN SGSH FZD6 THBS3 FBN1 STS CELSR3 CELSR2 LRP1 LTBP3 POMK NOTCH1 NOTCH3

6.95e-061201981435696571
Pubmed

Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.

FZD6 CELSR3 CELSR2

7.72e-061498339225402
Pubmed

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.

BMP2 BMP4 NOTCH1

7.72e-061498319084512
Pubmed

NOX2 Is Critical to Endocardial to Mesenchymal Transition and Heart Development.

BMP2 BMP4 NOTCH1

7.72e-061498332655758
Pubmed

Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis.

BMP2 BMP4 NOTCH1

7.72e-061498320123092
Pubmed

Proprotein convertase 5/6a is associated with bone morphogenetic protein-2-induced squamous cell differentiation.

PCSK5 BMP2

7.86e-06298225350918
Pubmed

Confocal laser scanning analysis of the association of fibulin-2 with fibrillin-1 and fibronectin define different stages of skin regeneration.

FBLN2 FBN1

7.86e-0629829886271
Pubmed

Phenotype characterization and sequence analysis of BMP2 and BMP4 variants in two Mexican families with oligodontia.

BMP2 BMP4

7.86e-06298223079991
Pubmed

Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome.

FBN1 LTBP3

7.86e-06298226494287
Pubmed

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.

ZFP36L1 ZFP36L2

7.86e-06298220622884
Pubmed

Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell.

ZFP36 ZFP36L1

7.86e-06298236385275
Pubmed

Polymorphisms in BMP2/BMP4, with estimates of mean lung dose, predict radiation pneumonitis among patients receiving definitive radiotherapy for non-small cell lung cancer.

BMP2 BMP4

7.86e-06298228574846
Pubmed

BMP2/BMP4 colorectal cancer susceptibility loci in northern and southern European populations.

BMP2 BMP4

7.86e-06298223161572
Pubmed

Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9.

CELSR3 CELSR2

7.86e-06298210790539
Pubmed

BMP2 and BMP4 variations and risk of non-syndromic cleft lip and palate.

BMP2 BMP4

7.86e-06298227591802
Pubmed

A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3.

NOTCH1 NOTCH3

7.86e-06298221191019
Pubmed

Association of bone morphogenetic proteins with otosclerosis.

BMP2 BMP4

7.86e-06298218021008
Pubmed

Cloning of rat type I receptor cDNA for bone morphogenetic protein-2 and bone morphogenetic protein-4, and the localization compared with that of the ligands.

BMP2 BMP4

7.86e-0629828896987
Pubmed

Fibrillin-1 and fibulin-2 interact and are colocalized in some tissues.

FBLN2 FBN1

7.86e-0629828702639
Pubmed

Exome sequencing identified new mutations in a Marfan syndrome family.

FBN1 LRP1

7.86e-06298224484584
Pubmed

BMP-2 induced Dspp transcription is mediated by Dlx3/Osx signaling pathway in odontoblasts.

BMP2 BMP4

7.86e-06298228883412
Pubmed

Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA.

ZFP36 ZFP36L1

7.86e-06298210751406
Pubmed

BMP-2 vs. BMP-4 expression and activity in glucocorticoid-arrested MC3T3-E1 osteoblasts: Smad signaling, not alkaline phosphatase activity, predicts rescue of mineralization.

BMP2 BMP4

7.86e-06298219021035
Pubmed

Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.

CASP2 ZYX

7.86e-06298214727142
Pubmed

Distinct roles for Notch1 and Notch3 in human adipose-derived stem/stromal cell adipogenesis.

NOTCH1 NOTCH3

7.86e-06298233021719
Pubmed

Lack of effect of bone morphogenetic protein 2 and 4 gene polymorphisms on bone density in postmenopausal Turkish women.

BMP2 BMP4

7.86e-06298221128211
Pubmed

Genetic variation in bone morphogenetic proteins family members (BMPs 2 and 4) and hypertension risk in middle-aged men: The TAMRISK study.

BMP2 BMP4

7.86e-06298229390526
Pubmed

Bone morphogenetic protein-2 antagonizes bone morphogenetic protein-4 induced cardiomyocyte hypertrophy and apoptosis.

BMP2 BMP4

7.86e-06298224648278
Pubmed

Absence of LTBP-3 attenuates the aneurysmal phenotype but not spinal effects on the aorta in Marfan syndrome.

FBN1 LTBP3

7.86e-06298230306291
Pubmed

ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner.

ZFP36L1 ZFP36L2

7.86e-06298229426877
Pubmed

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development.

BMP2 BMP4

7.86e-0629828413626
Pubmed

Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis.

NOTCH1 NOTCH3

7.86e-06298221768299
Pubmed

Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway.

NOTCH1 NOTCH3

7.86e-06298225700162
Pubmed

Evidence of Notch pathway activation in the ectatic ducts of chronic pancreatitis.

NOTCH1 NOTCH3

7.86e-06298218069660
Pubmed

Establishment of Immortalized BMP2/4 Double Knock-Out Osteoblastic Cells Is Essential for Study of Osteoblast Growth, Differentiation, and Osteogenesis.

BMP2 BMP4

7.86e-06298226595646
Pubmed

Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells.

VASN NOTCH1

7.86e-06298229198941
Pubmed

Microfibrils at basement membrane zones interact with perlecan via fibrillin-1.

HSPG2 FBN1

7.86e-06298215657057
Pubmed

Divergent and Compensatory Effects of BMP2 and BMP4 on the VSMC Phenotype and BMP4's Role in Thoracic Aortic Aneurysm Development.

BMP2 BMP4

7.86e-06298238727271
Pubmed

Cross-talk between fibroblast growth factor and bone morphogenetic proteins regulates gap junction-mediated intercellular communication in lens cells.

BMP2 BMP4

7.86e-06298218400943
Pubmed

Notch1 and Notch3 coordinate for pericyte-induced stabilization of vasculature.

NOTCH1 NOTCH3

7.86e-06298234878922
Pubmed

Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest.

BMP2 NOTCH1

7.86e-06298227146698
Pubmed

Epithelial Bone Morphogenic Protein 2 and 4 Are Indispensable for Tooth Development.

BMP2 BMP4

7.86e-06298234483952
Pubmed

Rare variants in BMP2 and BMP4 found in otosclerosis patients reduce Smad signaling.

BMP2 BMP4

7.86e-06298224492129
Pubmed

LTBP3 Pathogenic Variants Predispose Individuals to Thoracic Aortic Aneurysms and Dissections.

FBN1 LTBP3

7.86e-06298229625025
Pubmed

Notch 1 impairs osteoblastic cell differentiation.

BMP2 NOTCH1

7.86e-06298212960086
Pubmed

Enhanced Notch3 signaling contributes to pulmonary emphysema in a Murine Model of Marfan syndrome.

FBN1 NOTCH3

7.86e-06298232616814
Pubmed

Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment.

PCSK5 BMP2

7.86e-06298220555025
Pubmed

Comparative immunolocalisation of fibrillin-1 and perlecan in the human foetal, and HS-deficient hspg2 exon 3 null mutant mouse intervertebral disc.

HSPG2 FBN1

7.86e-06298223104139
Pubmed

Bone morphogenetic proteins 2 and 4 are selectively expressed by late outgrowth endothelial progenitor cells and promote neoangiogenesis.

BMP2 BMP4

7.86e-06298218818419
Pubmed

Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling.

BMP2 BMP4

7.86e-06298218628975
Pubmed

Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.

FBN1 FBN3

7.86e-06298215221638
Pubmed

Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression.

BMP2 BMP4

7.86e-06298227146352
Pubmed

Inhibition of BMP2 and BMP4 Represses Barrett's Esophagus While Enhancing the Regeneration of Squamous Epithelium in Preclinical Models.

BMP2 BMP4

7.86e-06298236706916
Pubmed

Titanium With Nanotopography Induces Osteoblast Differentiation by Regulating Endogenous Bone Morphogenetic Protein Expression and Signaling Pathway.

BMP2 BMP4

7.86e-06298226681207
Pubmed

The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance.

NOTCH1 NOTCH3

7.86e-06298226634853
Pubmed

Characterization of DeltaN-Zfp36l2 mutant associated with arrest of early embryonic development and female infertility.

ZFP36L1 ZFP36L2

7.86e-06298222367205
InteractionFBLN2 interactions

HSPG2 ZNF142 ZNF316 FBLN2 FBN1 ZNF358

5.96e-0766936int:FBLN2
InteractionTGFB2 interactions

VASN CUL9 BMP2 LTBP3

5.88e-0626934int:TGFB2
InteractionPRG2 interactions

PCSK5 HSPG2 SGSH BMP4 CELSR2 LTBP3 POMK NOTCH1 NOTCH3

6.79e-06285939int:PRG2
InteractionFBXO2 interactions

PCSK5 HSPG2 VASN SGSH BMP4 FBN1 CELSR3 POMK NOTCH1 NOTCH3

2.00e-054119310int:FBXO2
InteractionCACNA1A interactions

PCSK5 HSPG2 EFEMP2 LRP1 LTBP3 NOTCH1

2.26e-05123936int:CACNA1A
InteractionNOTCH2 interactions

ZNF142 VASN ZNF689 ZNF316 POLRMT ZYX ZNF358 NOTCH1 NOTCH3 ZNF574

2.55e-054239310int:NOTCH2
InteractionCACNG5 interactions

ZNF142 ZNF316 POLRMT ZNF574

3.78e-0541934int:CACNG5
InteractionHOXA1 interactions

PCSK5 VASN EFEMP2 FBLN2 GUCD1 FBN1 LTBP3 NOTCH1 NOTCH3

3.95e-05356939int:HOXA1
CytobandEnsembl 112 genes in cytogenetic band chr9q12

SPATA31A7 SPATA31A5

1.25e-048982chr9q12
Cytoband9p13.1

SPATA31A3 SPATA31A1

1.21e-03249829p13.1
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZNF784 LGI4 ZFP36 ZNF835 FCGBP ZNF296 KIR3DL3 ZNF574

4.06e-031192988chr19q13
Cytoband7p22.1

ZNF316 RNF216

4.58e-03479827p22.1
Cytoband12q24.33

ZNF605 NOC4L

4.77e-034898212q24.33
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF384 ZNF142 ZNF366 ZNF689 ZNF316 ZFP57 ZNF784 ZBTB7B ZNF835 BCL6B GFI1B ZNF605 ZNF296 ZNF358 ZNF574 ZNF513

4.34e-09718661628
GeneFamilySulfatases

SGSH STS ARSD

3.65e-0518663410
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR3 CELSR2

3.93e-053662913
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR3 CELSR2

3.93e-0536621189
GeneFamilyFibulins

EFEMP2 FBLN2

3.62e-048662556
GeneFamilyBone morphogenetic proteins|Astacins

BMP2 BMP4

7.07e-0411662455
GeneFamilyRing finger proteins

RNF126 ZFP36 ZFP36L1 ZFP36L2 RNF216

3.29e-0327566558
CoexpressionNABA_ECM_GLYCOPROTEINS

EFEMP2 LGI4 EYS THBS3 FBLN2 FBN1 LTBP3 FBN3

6.40e-07196968M3008
CoexpressionNABA_CORE_MATRISOME

HSPG2 EFEMP2 LGI4 EYS THBS3 FBLN2 FBN1 LTBP3 FBN3

7.90e-07275969M5884
CoexpressionNABA_MATRISOME

PCSK5 HGFAC HSPG2 HBEGF EFEMP2 LGI4 F12 BMP2 BMP4 EYS THBS3 FBLN2 FBN1 LTBP3 FBN3

4.72e-0610269615M5889
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HENDO

HSPG2 ZNF366 HBEGF ITPRID2 ZYX ZFP36 FZD6 BCL6B BMP4 FBLN2 ZFP36L1 ZFP36L2 ADGRL2

2.13e-058889613M39049
CoexpressionESC_V6.5_UP_EARLY.V1_DN

HBEGF BMP4 FBLN2 ZFP36L1 TBXT LTBP3

3.08e-05163966M2769
CoexpressionAMIT_DELAYED_EARLY_GENES

ZFP36 ZFP36L1 ZFP36L2

3.73e-0518963M10550
CoexpressionNABA_CORE_MATRISOME

HSPG2 EFEMP2 LGI4 THBS3 FBLN2 FBN1 LTBP3

6.22e-05270967MM17057
CoexpressionNABA_ECM_GLYCOPROTEINS

EFEMP2 LGI4 THBS3 FBLN2 FBN1 LTBP3

7.45e-05191966MM17059
CoexpressionNABA_MATRISOME

PCSK5 HGFAC HSPG2 HBEGF EFEMP2 LGI4 F12 BMP2 BMP4 THBS3 FBLN2 FBN1 LTBP3

7.83e-0510089613MM17056
CoexpressionAIZARANI_LIVER_C21_STELLATE_CELLS_1

ZFP36 BMP2 FBLN2 FBN1 ZFP36L1 LRP1

8.12e-05194966M39122
CoexpressionHE_LIM_SUN_FETAL_LUNG_C3_ARTERIAL_ENDOTHELIAL_CELL

PCSK5 HBEGF ZBTB7B ADA2 FZD6 FBLN2 FBN1

8.91e-05286967M45746
CoexpressionGSE2405_0H_VS_24H_A_PHAGOCYTOPHILUM_STIM_NEUTROPHIL_DN

BMP2 PRIM2 LRP1 RNF216 HAGH NOTCH3

9.60e-05200966M6193
CoexpressionTHAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN

ZNF142 ADA2 RNF126 ZYX ZFP36 PIGQ ZNF296 ZFP36L2 PLCH2 RNF216 NOTCH1 ZNF513

1.16e-049059612M40865
ToppCellfacs-Trachea-nan-3m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 HSPG2 VASN THBS3 FBLN2 FBN1 LRP1 LTBP3

1.26e-081989780dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 HSPG2 VASN EFEMP2 THBS3 FBN1 LRP1 LTBP3

1.26e-081989781b90d632e59c3c47b936e829cceeb0334f05f34f
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

PCSK5 ZFP36 BCL6B ZFP36L1 ZFP36L2 PTCH2 LTBP3

1.86e-07188977c90669b51e1902fe7726555290c91c92a911df83
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 VASN LGI4 THBS3 FBLN2 FBN1 LTBP3

1.86e-07188977bba6b273bd47dd0e27fde914e9e6fc9d76fd5176
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VASN BMP2 THBS3 FBLN2 FBN1 MRGPRG LRP1

1.93e-071899770a8b827bba1efd885ad6c06929251c741dc3a541
ToppCell(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells|(0)_Normal/No_Treatment / Stress and Cell class

VASN EFEMP2 BMP4 FBN1 ZFP36L1 LRP1 NOTCH3

2.15e-071929777a2ad0bdae647b88e799e62767605f2f3c5a426f
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 VASN EFEMP2 THBS3 FBLN2 FBN1 LRP1

2.22e-07193977428b1a3ad87dff7f65de5161d40f102572a9341b
ToppCellMesenchymal_cells|World / Lineage and Cell class

HSPG2 VASN EFEMP2 BMP4 FBLN2 FBN1 LRP1

2.38e-07195977380eb436baa371f7aa2dc0c4a594afb173b5a25b
ToppCellfacs-Trachea|facs / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 VASN BMP2 THBS3 FBLN2 FBN1 LRP1

2.47e-071969778209f2b0f7efebaaf81d642d18a1aee8a9a8dcf6
ToppCellfacs-Trachea|facs / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 VASN BMP2 THBS3 FBLN2 FBN1 LRP1

2.47e-0719697734020d6553309daa269dff05de0a8567211ea4d2
ToppCell10x3'2.3-week_14-16-Mesenchymal_adipo-stroma-adipo-CAR|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PCSK5 VASN EFEMP2 FBN1 ZFP36L1 ADGRL2 NOTCH3

2.64e-07198977a8c21f4db6730d0aa05b61fbe72bf9f7571a9015
ToppCell10x3'2.3-week_14-16-Mesenchymal_adipo-stroma|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PCSK5 VASN EFEMP2 FBN1 ZFP36L1 ADGRL2 NOTCH3

2.64e-071989778b68fc887e5ad0a59ea4d93dfd1edda67030f142
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 HSPG2 VASN EFEMP2 THBS3 FBN1 LTBP3

2.64e-07198977b086af292a508a156266c2d899ba1caf820bf61c
ToppCell10x3'2.3-week_14-16-Mesenchymal_adipo|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PCSK5 VASN EFEMP2 FBN1 ZFP36L1 ADGRL2 NOTCH3

2.64e-071989774739b2e4ab141c66772e61686b45614a1839483e
ToppCellfacs-Trachea-nan-3m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 VASN EFEMP2 BMP2 FBN1 LRP1 LTBP3

2.73e-0719997767f78c070c56e44fba36542041bf7fa1c291807c
ToppCellfacs-Trachea-nan-3m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 VASN EFEMP2 BMP2 FBN1 LRP1 LTBP3

2.73e-071999771ae244b563f85c1ee8d22698f478c842a4d9c7f5
ToppCellsevere_COVID-19-cDC|World / disease group, cell group and cell class (v2)

ZNF366 CRIP3 BMP2 FBLN2 FBN1 ZNF296

1.20e-061569760a7e18ed8e13261c405eb6b9a183e99d8e1aac37
ToppCellAdult-Immune-enucleated_erythrocyte-D231|Adult / Lineage, Cell type, age group and donor

HGFAC BMP2 ZNF296 ZNF358 PLCH2 NOTCH1

2.50e-0617797615ee303fb6caea1fd645c3b777666196ce500a1c
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

PCSK5 HSPG2 ZNF366 BCL6B FBLN2 FBN1

2.67e-061799761ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 ITPRID2 BMP2 BMP4 FBLN2 FBN1

2.94e-06182976c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 ITPRID2 BMP2 BMP4 FBLN2 FBN1

2.94e-06182976d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PIGQ BMP4 FBLN2 ZNF358 HAGH NOTCH1

3.23e-0618597687151ab95530e70d61328b336518df58db584acb
ToppCell(1)_Control_(PBS)-(2)_LEPR+_perivascular_cells_and_VE-Cad+_vascular_cells_(mixed)|World / Stress and Cell class

VASN EFEMP2 ZFP36 ZFP36L1 LRP1 NOTCH3

3.23e-06185976b8cd94cf18308b514fc61557550225794ffd2860
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LGI4 THBS3 FBLN2 FBN1 MRGPRG PTCH2

3.43e-06187976fa8f221b4c2df61eadaa9c77e4cf45848b00330b
ToppCellEndothelial-Endothelial-E|Endothelial / shred on cell class and cell subclass (v4)

HSPG2 ITPRID2 BMP4 FBLN2 FBN1 LTBP3

3.54e-061889762777eb7689b271c199021fe7d9db88ccebff14de
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VASN BMP2 THBS3 FBLN2 FBN1 LRP1

3.54e-061889762cfa41c64eccb28b5e22f0f91bbc921b75713245
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 EFEMP2 THBS3 FBLN2 FBN1 LRP1

3.65e-06189976bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCelldroplet-Limb_Muscle-nan-21m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VASN BMP2 THBS3 FBLN2 FBN1 LRP1

3.65e-0618997656f43e00d81cf3cdf0c39f8d7120f5beab72e258
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 HSPG2 ITPRID2 FZD6 FBLN2 FBN1

3.65e-06189976b028466fcd36fdeceec752e55a24286a1cd62ae4
ToppCellLPS-IL1RA-Endothelial-Endothelial-Artery|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 HSPG2 ITPRID2 FZD6 FBLN2 FBN1

3.76e-06190976aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell(1)_Control_(PBS)-(3)_LEPR+_perivascular_cells|World / Stress and Cell class

EFEMP2 BMP4 FBN1 ZFP36L1 LRP1 NOTCH3

3.76e-06190976ec0ab31266583a0966ac7615d5c0fabb7b7e66e8
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 EFEMP2 THBS3 FBLN2 FBN1 LRP1

3.76e-06190976f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 EFEMP2 THBS3 FBLN2 FBN1 LRP1

3.76e-06190976c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 EFEMP2 THBS3 FBLN2 FBN1 LRP1

3.76e-0619097647077579496c5340e99f61499427a3a36b566da3
ToppCelldroplet-Mammary_Gland-nan-21m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 ZFP36 FBLN2 FBN1 ZFP36L1 LRP1

3.88e-061919768022059e434fd411dc539819f969bd4f94861281
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 EFEMP2 THBS3 FBLN2 FBN1 LRP1

3.88e-06191976a57cf0519d749febc0b69fe0b098b7ba53d63258
ToppCelldroplet-Mammary_Gland-nan-18m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 EFEMP2 THBS3 FBLN2 FBN1 LRP1

3.88e-0619197619c67a812b8ce97472d316acd15aeefe8736000d
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 HSPG2 ITPRID2 FZD6 FBLN2 FBN1

3.88e-061919764b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VASN EFEMP2 BMP2 FBLN2 FBN1 LRP1

3.88e-061919761b26056df078674f37a6c06f6256b30cfcec21a7
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 THBS3 FBLN2 FBN1 LRP1 LTBP3

4.00e-06192976a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 EFEMP2 THBS3 FBLN2 FBN1 LRP1

4.00e-061929767b48df661f61ce494bf6f0b9a74b0422e29c24bf
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 THBS3 FBLN2 FBN1 LRP1 LTBP3

4.00e-06192976eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VASN EFEMP2 THBS3 FBLN2 FBN1 LRP1

4.00e-06192976fc940f91ff8e051631dbf25e6e8d73cf8337eccb
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VASN EFEMP2 THBS3 FBLN2 FBN1 LRP1

4.00e-06192976beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 THBS3 FBLN2 FBN1 LRP1 LTBP3

4.00e-0619297632acd89617934016cd135d2cc797e8e79ae1b37f
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VASN EFEMP2 THBS3 FBLN2 FBN1 LRP1

4.00e-061929767a2e79490e4f7058bb76b46c45b5df9f729e3146
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 THBS3 FBLN2 FBN1 LRP1 LTBP3

4.00e-06192976011634a24b0c61d9b463fe755502edbc5cd70b7a
ToppCellfacs-Trachea-24m-Mesenchymal|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VASN EFEMP2 THBS3 FBLN2 FBN1 LRP1

4.00e-06192976e8af6ad1ae99cae13a82d0d8d7f38af9b777f0ba
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 VASN EFEMP2 THBS3 FBN1 LRP1

4.12e-06193976eff718664fe0aaf89050efd9cc7b6dfb1df46666
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VASN EFEMP2 THBS3 FBLN2 FBN1 LRP1

4.12e-0619397625248b8e65d558b1a96a87c93e3e5b4c0ba168fe
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VASN EFEMP2 THBS3 FBLN2 FBN1 LRP1

4.12e-06193976f1f1097204e07a7bed416425b8256942038a734f
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 EFEMP2 FBLN2 FBN1 LRP1 LTBP3

4.12e-0619397645b5cab4dfeb0ed3b13631db5963740a792b810f
ToppCellfacs-BAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 VASN EFEMP2 THBS3 FBN1 LTBP3

4.24e-06194976da45811ba07d746e7cba7ed78882b5d98ac7397d
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PCSK5 BMP2 LRP1 LTBP3 GNAS ADGRL2

4.24e-0619497608fad7591c20568de797cf8e206de2d0b1d78aab
ToppCellfacs-BAT-Fat-3m-Mesenchymal|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 VASN EFEMP2 THBS3 FBN1 LTBP3

4.24e-0619497676b8512fd92014b3ecc42b0a20d6d1df074cba2c
ToppCellfacs-BAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 VASN EFEMP2 THBS3 FBN1 LTBP3

4.24e-06194976ef0fa9daecd3bf43c6cf56345928cacdbee19779
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 HSPG2 EFEMP2 THBS3 FBN1 LTBP3

4.37e-0619597669a29d03e664b72f32d41876510c62345c3aed31
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VASN EFEMP2 THBS3 FBLN2 FBN1 LRP1

4.37e-06195976773728703bc8969bff0e1de58fe3e1631add0a0a
ToppCellfacs-GAT-Fat-3m-Mesenchymal|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 HSPG2 EFEMP2 THBS3 FBN1 LTBP3

4.37e-061959761cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCellfacs-Trachea-18m-Mesenchymal|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VASN EFEMP2 THBS3 FBLN2 FBN1 LRP1

4.37e-061959760d1876f6fdc1eafeb60d6fd7da5bce737d2b4a5a
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 HSPG2 EFEMP2 THBS3 FBN1 LTBP3

4.37e-061959769cef6f18664518060af7c192310dddce6d70345a
ToppCellfacs-SCAT-Fat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VASN EFEMP2 FBLN2 FBN1 MRGPRG LRP1

4.50e-0619697665f2f51e17f1869f3468813127b96d3048d8ad41
ToppCellfacs-SCAT-Fat-18m-Mesenchymal-mesenchymal_progenitor|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VASN EFEMP2 FBLN2 FBN1 MRGPRG LRP1

4.50e-06196976e4ed897900a6472738bc6be2fb4817192727225d
ToppCellfacs-SCAT-Fat-18m-Mesenchymal|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VASN EFEMP2 FBLN2 FBN1 MRGPRG LRP1

4.50e-061969762cd83176f2e8a9e6fa3c08cb33928a61e5fc43b6
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 THBS3 FBLN2 FBN1 LRP1 LTBP3

4.50e-06196976b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 THBS3 FBLN2 FBN1 LRP1 LTBP3

4.50e-06196976787c6cd92035e0b1108c2c086c42a229016e476b
ToppCell15-Airway-Mesenchymal-Mesenchyme_SERPINF1-high|Airway / Age, Tissue, Lineage and Cell class

EFEMP2 BMP4 FBLN2 FBN1 ZFP36L1 LRP1

4.77e-061989763d76393e72eed59b4dd16130ef5dd1d331ba5711
ToppCelldroplet-Trachea-nan-3m-Mesenchymal-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VASN EFEMP2 BMP2 FBN1 LRP1 LTBP3

4.77e-06198976d3a475be01657a03fcbb0ee0a246b1e90deacaa4
ToppCelldroplet-Trachea-3m-Mesenchymal|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VASN EFEMP2 BMP2 FBN1 LRP1 LTBP3

4.77e-061989761beed34f469aad07e8f674f0b668d6e1e916403c
ToppCelldroplet-Trachea-nan-3m-Mesenchymal|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VASN EFEMP2 BMP2 FBN1 LRP1 LTBP3

4.77e-06198976985022c1722ab7b67675ebe814022a439e715b5e
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 VASN EFEMP2 THBS3 LRP1 LTBP3

4.77e-06198976524305c5d7b1d53e86ec0af775efefa3e0955e47
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EFEMP2 ZFP36 FBLN2 FBN1 ZFP36L1 NOTCH3

4.91e-06199976c007cd51577e31553395ceaed70ad447e5854546
ToppCelldroplet-Trachea|droplet / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSPG2 VASN HBEGF BMP2 FBN1 LTBP3

4.91e-061999761c7d30765ddb2291967da5d15664c6238c680c1d
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

EFEMP2 ZYX BMP4 FBN1 ZFP36L1 LRP1

4.91e-0619997630d3e8c0681ec11f86dd38c5f48d21187a1b4f90
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

EFEMP2 ZYX BMP4 FBN1 ZFP36L1 LRP1

4.91e-06199976e1849505b92820a219c5a2c35492bdd55579fb48
ToppCelldroplet-Trachea|droplet / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HSPG2 VASN HBEGF BMP2 FBN1 LTBP3

4.91e-06199976b9038a1ccf3ef3123e2e39afbe6213c363437443
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

EFEMP2 ZYX BMP4 FBN1 ZFP36L1 LRP1

5.05e-06200976ab4fda0cc95cb8f80ea9f28745013f3248def820
ToppCell15-Airway|15 / Age, Tissue, Lineage and Cell class

VASN EFEMP2 ZFP36 FBLN2 FBN1 ZFP36L2

5.05e-06200976ba4b8d5becf81351901c2ecac74ffa28e29586f3
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Artery|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PCSK5 ITPRID2 FZD6 FBLN2 FBN1 GNAS

5.05e-0620097677ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell3'-Adult-LargeIntestine-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VASN EFEMP2 BMP4 FBLN2 FBN1 LRP1

5.05e-0620097687177c973e722ac7d9ee503b9cfacd84fc67865d
ToppCell3'-Adult-LargeIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VASN EFEMP2 BMP4 FBLN2 FBN1 LRP1

5.05e-06200976cbf6a6c3db88bac37bd084a3a914b12b3af524eb
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_adventitial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK5 VASN EFEMP2 FBLN2 FBN1 LRP1

5.05e-0620097674ad0ae592252060ee294d7483327d765a6ba1dd
ToppCellLPS_only-Endothelial-Endothelial-Artery|LPS_only / Treatment groups by lineage, cell group, cell type

PCSK5 ITPRID2 FZD6 FBLN2 FBN1 GNAS

5.05e-06200976b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCellTracheal-10x5prime-Stromal-Fibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK5 VASN EFEMP2 FBLN2 FBN1 LRP1

5.05e-062009767ba292c30d915e66ebc8026fa76492cedf64700e
ToppCellTracheal-10x5prime-Stromal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PCSK5 VASN EFEMP2 FBLN2 FBN1 LRP1

5.05e-06200976920e6036c0a9c0089d0d898673daf9dd9d7279fc
ToppCellsevere_COVID-19-cDC|severe_COVID-19 / disease group, cell group and cell class (v2)

ZNF366 CRIP3 BMP2 FBLN2 ZNF296

2.41e-05157975ec1978e07e2214048d015d8bb793c1d9991f6e37
ToppCell10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor|lymph-node_spleen / Manually curated celltypes from each tissue

LGI4 FZD6 GFI1B FBN1 ADGRL2

3.06e-051659757b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 ITPRID2 FZD6 FBLN2 NOTCH1

3.15e-051669757a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 ITPRID2 FZD6 FBLN2 NOTCH1

3.15e-05166975bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

VASN EFEMP2 BMP2 SCNN1D NOTCH3

3.25e-05167975f4943fb5001475ddab82a0273bcbb3fa68fdd7bd
ToppCell3'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HBEGF FCGBP ZNF296 ZFP36L2 PTCH2

3.34e-051689752163e6774eb7a3d010422e4d59be5e45b4158329
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

HBEGF PARS2 PLCH2 SCNN1D OSBPL10

3.84e-0517397542c911ed16fabdabef063830e8407192d8bde950
ToppCellBasal-basal-3|World / Class top

HBEGF FMO6P ZFP36 ZNF296 ZFP36L1

4.06e-05175975a0d7ced5204a9efbbb91ac99410a088f8ed2df0f
ToppCell(0)_Normal/No_Treatment-(3)_LEPR+_perivascular_cells|World / Stress and Cell class

EFEMP2 FBN1 ZFP36L1 LRP1 NOTCH3

4.17e-05176975ce2c32b5ce0da848eb4da35ce4d215cdf74d9113
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PCSK5 HSPG2 EFEMP2 BCL6B FBLN2

4.52e-05179975d2db9e70b780643f1e004c41a70464d0abe26088
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HSPG2 HBEGF LGI4 GFRA3 FBLN2

4.64e-05180975b294f9db1e2ff51c94cde64fae4c2b057c0030a1
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PCSK5 ITPRID2 FZD6 FBLN2 NOTCH1

4.76e-051819754d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCellControl-Myeloid-DC1|Control / Condition, Lineage and Cell class

HSPG2 ZNF366 CRIP3 FZD6 ZNF296

4.76e-051819755a2a1f017ad23baed9972c68b4a46f4c618ef21a
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Mature_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 HSPG2 BCL6B EYS FBLN2

4.76e-051819750ba91575fe8851788cebc4cf5a6d76680bf586c5
ToppCelldroplet-Limb_Muscle-nan-21m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VASN BMP2 FBLN2 MRGPRG LRP1

4.89e-05182975a51cbdb8d6528a82044be838c70c492fc6370891
Drugpyrachlostrobin

HSPG2 VASN HBEGF EFEMP2 ITPRID2 ZBTB7B ZFP36 FZD6 BMP4 FBLN2 FBN1 ZFP36L2 LTBP3 NOTCH1 NOTCH3

9.74e-078119315ctd:C513428
Drug1-anilino-4-methyl-2-methylthio-4-phenylimidazolin-5-one

HSPG2 VASN HBEGF ITPRID2 ZBTB7B ZYX FBN1 ZFP36L2 NOTCH1 NOTCH3

2.98e-063739310ctd:C540355
Drugnordihydroguaiaretic acid; Up 200; 1uM; MCF7; HT_HG-U133A

CASP2 BMP2 STS ARSD ZNF358 TBXT GNAS

1.60e-051969375583_UP
DrugDesipramine hydrochloride [58-28-6]; Down 200; 13.2uM; MCF7; HT_HG-U133A

HSPG2 CASP2 THBS3 STS ZFP36L2 RNF216 ZNF574

1.65e-051979373212_DN
DrugCarbachol [51-83-2]; Down 200; 21.8uM; PC3; HT_HG-U133A

HSPG2 SGSH EFEMP2 ZFP36L2 ZNF358 LRP1 NOTCH3

1.70e-051989376742_DN
DrugICI 182,780; Down 200; 0.01uM; PC3; HT_HG-U133A

HSPG2 ZNF142 CASP2 EPN2 THBS3 NOTCH3 ZNF574

1.70e-051989371238_DN
DiseaseMarfan syndrome (implicated_via_orthology)

BMP2 BMP4 FBN1

3.46e-0610923DOID:14323 (implicated_via_orthology)
Diseaseaortic aneurysm (is_implicated_in)

EFEMP2 FBN1

2.88e-053922DOID:3627 (is_implicated_in)
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN3

2.88e-053922DOID:65 (implicated_via_orthology)
DiseaseGeleophysic dysplasia

FBN1 LTBP3

9.56e-055922C3489726
DiseaseAcromicric Dysplasia

FBN1 LTBP3

9.56e-055922C0265287
Diseaseparathyroid hormone-related protein measurement

ADA2 F12

1.43e-046922EFO_0020622
Diseaserenal overload-type gout

SPATA31C2 SPATA31C1

1.43e-046922EFO_0021525
Diseaseotosclerosis (is_implicated_in)

BMP2 BMP4

1.43e-046922DOID:12185 (is_implicated_in)
Diseasebody surface area

PCSK5 SPATA31C2 SIM1 SPATA31C1 GFRA3 FBLN2 FBN1 LTBP3 GNAS

1.82e-04643929EFO_0022196
DiseaseSacral agenesis

PCSK5 TBXT

2.00e-047922C0344490
Diseaseadenocarcinoma (implicated_via_orthology)

NOTCH1 NOTCH3

2.00e-047922DOID:299 (implicated_via_orthology)
Diseasecentral nervous system cancer (implicated_via_orthology)

NOTCH1 NOTCH3

2.00e-047922DOID:3620 (implicated_via_orthology)
Diseaselow density lipoprotein cholesterol measurement, alcohol consumption measurement

PCSK5 HGFAC SIM1 CELSR2

2.66e-0499924EFO_0004611, EFO_0007878
Diseaseeosinophil cationic protein measurement

SPATA31C2 SPATA31C1

2.66e-048922EFO_0010913
Diseasecreatinine measurement

HGFAC SIM1 CRIP3 F12 BMP4 THBS3 CELSR3 CELSR2 ZFP36L2 GNAS ADGRL2

2.70e-049959211EFO_0004518
Diseaselow density lipoprotein cholesterol measurement, alcohol drinking

PCSK5 HGFAC SIM1 CELSR2

2.98e-04102924EFO_0004329, EFO_0004611
Diseaselongitudinal alcohol consumption measurement

SPATA31C2 SPATA31C1

3.41e-049922EFO_0007645
DiseaseBone Diseases

BMP2 LTBP3

4.26e-0410922C0005940
Diseaseaortic aneurysm

FBN1 LRP1

4.26e-0410922EFO_0001666
Diseasetooth agenesis (is_implicated_in)

BMP2 BMP4

4.26e-0410922DOID:0050591 (is_implicated_in)
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

EFEMP2 FBN1 NOTCH1

6.14e-0453923C4707243
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

BMP2 BMP4

7.33e-0413922DOID:0050787 (implicated_via_orthology)
DiseaseCardiotoxicity

HBEGF BMP2

7.33e-0413922C0876994
DiseaseMigraine Disorders

LRP1 NOTCH3

7.33e-0413922C0149931
Diseaseegg allergy measurement, parental genotype effect measurement

SPATA31C2 SPATA31C1

7.33e-0413922EFO_0005939, EFO_0007018
DiseaseGlobal developmental delay

ZNF142 LGI4 PIGQ BMP4

8.11e-04133924C0557874
Diseaseintraocular pressure measurement

PCSK5 ZNF366 FBN1 ZFP36L2 ANAPC1 PTCH2 LTBP3

1.08e-03509927EFO_0004695
DiseaseSpermatogenic Failure, Nonobstructive, Y-Linked

USP9Y BPY2

1.12e-0316922C1839071
DiseaseSpermatogenic failure, Y-linked, 2

USP9Y BPY2

1.12e-0316922cv:C1839071
Diseaseamygdala volume change measurement

SPATA31C2 SPATA31C1

1.12e-0316922EFO_0021490
DiseaseSPERMATOGENIC FAILURE, Y-LINKED, 2

USP9Y BPY2

1.12e-0316922415000
Diseasefibrinogen measurement, coronary artery disease

HGFAC CELSR2 ZFP36L1 PRIM2

1.40e-03154924EFO_0001645, EFO_0004623
DiseaseColorectal Carcinoma

GFI1B BMP2 BMP4 FBLN2 ZFP36L2 LRP1 C12orf76 GNAS

1.59e-03702928C0009402
Diseasehydrocephalus (implicated_via_orthology)

CELSR2 POMK

1.59e-0319922DOID:10908 (implicated_via_orthology)
Diseaseprostate carcinoma (is_marker_for)

BMP2 BMP4

2.33e-0323922DOID:10286 (is_marker_for)
Diseaseunipolar depression, neuroticism measurement

ZNF366 EYS

2.54e-0324922EFO_0003761, EFO_0007660
DiseaseCarcinoma, Pancreatic Ductal

NOTCH1 NOTCH3

2.54e-0324922C0887833
Diseaseblood urea nitrogen measurement

SIM1 MRPS30 BMP4 THBS3 GNAS ADGRL2

2.94e-03452926EFO_0004741
Diseaseresponse to perphenazine

MRPS30 ADGRL2

2.98e-0326922GO_0097334
Diseasebrain cancer (implicated_via_orthology)

NOTCH1 NOTCH3

2.98e-0326922DOID:1319 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
HYTTPQFHPEGAGAC

ARSD

481

P51689
DGGSCPAHYPVHECV

ANKRD13C

106

Q8N6S4
HSYCCGGLPTESPHS

ADGRL2

1101

O95490
CHCKENHYRPPGSPT

CELSR2

1906

Q9HCU4
RCFPHVHAVSFRSCP

DNHD1

1386

Q96M86
FQCECPPGYHLSEHT

FBN3

1586

Q75N90
GAFTCRCPPGFTQHH

FBN3

2466

Q75N90
RCPPGFTQHHQACFD

FBN3

2471

Q75N90
HAFYCHGECPFPLAD

BMP2

321

P12643
YCHGDCPFPLADHLN

BMP4

336

P12644
QRGPCPDGHFYLEHS

HSPG2

501

P98160
CALYPHFPAHSTDNR

ANAPC1

1586

Q9H1A4
RNHLCFGHCSSLYIP

DAND5

121

Q8N907
SYICHCPPSFHGPTC

NOTCH1

161

P46531
TFTCLCRPGYTGHHC

NOTCH1

586

P46531
HCSRGATCISLPHGY

EYS

2661

Q5T1H1
NASCHPAFPVEYSHA

IRF1-AS1

51

Q8N8D9
YPCSSSHFRRSGQHP

GEMIN8

86

Q9NWZ8
YHGSPEASLCPQHRT

EPN2

196

O95208
IHSDTRPYPCQFCGK

GFI1B

241

Q5VTD9
PCHTSGHICYFVSKP

HAGH

156

Q16775
YCACRSGFHTVPGQP

LRP1

3806

Q07954
YAAGHTVHLPPCRAC

FBLN2

146

P98095
NTRICVSSCPPGHYH

PCSK5

666

Q92824
SCPRGFYADSRHCVP

PCSK5

1356

Q92824
TPAHAGTYRCCSSHP

KIR3DL3

86

Q8N743
SHPCAHEPCSHGICY

NOTCH3

696

Q9UM47
CSGHHVYPNLPTDSF

FMO6P

146

O60774
PQSYHCSCPRAFTGK

HGFAC

181

Q04756
FASPFGCPYSHRHAT

ITPRID2

881

P28290
LPFCGPHEINHFFCE

OR2A5

166

Q96R48
SDLFPACYQGCRPRH

MRGPRG

106

Q86SM5
PSQGDYHGCPFRHSD

PRIM2

376

P49643
SDHCRQYHIPCPYQA

FZD6

451

O60353
PSGHHCFCRTPDYQG

GUCD1

171

Q96NT3
GEKPYHCDPCGLHFR

BCL6B

436

Q8N143
AYGEACSGPHCQRHV

GFRA3

181

O60609
DFCPFQCPAHSHYEL

FCGBP

2331

Q9Y6R7
FQCPAHSHYELCGDS

FCGBP

3536

Q9Y6R7
RPDFCPLQCPAHSHY

FCGBP

4731

Q9Y6R7
ACNPGYHSTPDRLFC

FBN1

1181

P35555
HCYCPVGFGRRTDPN

CRY1

411

Q16526
ASGDGRHYCYPHFTC

GNAS

351

P63092
RNVTYRPHCHICFTP

ADA2

126

Q9NZK5
EHNGRPYCHKPCYGA

CRIP3

46

Q6Q6R5
DYSCHCNPGYRSHPQ

LTBP3

596

Q9NS15
CNPGYRSHPQHRYCV

LTBP3

601

Q9NS15
SFHRCSVYGVPTPHF

EFHB

441

Q8N7U6
NCSFPEAHYPASCGH

CUL9

2191

Q8IWT3
PHHLVYCDFPTNITC

DCAF8L1

381

A6NGE4
ELRAPSCICHPGYHG

HBEGF

126

Q99075
CRHLPGAPHGYTCDC

CELSR3

1996

Q9NYQ7
EPGRFSCHCPQGYQL

EFEMP2

261

O95967
HPLPAGAEYCSSARH

SCNN1D

576

P51172
DFRGRTYPCPPHFNH

POLRMT

801

O00411
YHSCCNRLGELLGHP

NOC4L

96

Q9BVI4
CSTLCRHLYLFPGHP

CASP2

436

P42575
TVTGEPCHFPFQYHR

F12

41

P00748
PCCYGHTQFHLLPDK

MRPS30

291

Q9NP92
LSGYVPCRFHHCAPR

PARS2

21

Q7L3T8
RAGQDHYSHPCPRFS

BPY2

11

O14599
QAPVCGFPCNHRHPF

SPATA31C2

1086

B4DYI2
CRDGPGFYPHQSLHA

LGI4

346

Q8N135
LPHGTHAFHAACPFC

PELI2

386

Q9HAT8
AYVGRPCLHPDDLHC

PTCH2

246

Q9Y6C5
TLLCAPEHGRPCYHT

PIGQ

596

Q9BRB3
APVCGFPCNHRHLFY

SPATA31A7

1241

Q8IWB4
MAEASPHPGRYFCHC

RNF126

1

Q9BV68
PHPGRYFCHCCSVEI

RNF126

6

Q9BV68
VCFCFGSYVTHHDPP

STS

486

P08842
PGAEPAAHCYCGHQF

SELENOO

131

Q9BVL4
HPTVSPNCFGSHRQY

SIM1

691

P81133
QKYSEHFSIHCCPPF

MOBP

16

Q13875
SINGYDHFCQHPRSP

RNF216

706

Q9NWF9
RQSTVDPTHCPYGHF

POMK

46

Q9H5K3
FQAPVCGFPCNHRHP

SPATA31C1

1091

P0DKV0
CGFPCNHRHPFYSDH

SPATA31C1

1096

P0DKV0
AFHDPHRCGHSQPQY

SGSH

176

P51688
HRCGHSQPQYGTFCE

SGSH

181

P51688
EQVSHHPPISCFYCE

OSBPL10

531

Q9BXB5
ACPPSFYGRNCEHDV

TDGF1

96

P13385
FQHPAGDCHPYGILC

C12orf76

106

Q8N812
APVCGFPCNHRHLFY

SPATA31A3

1241

Q5VYP0
ACSLCPFATHYPNHL

ZNF513

361

Q8N8E2
FCPYGPRCHFIHNAE

ZFP36L1

166

Q07352
IHTGDRPYKCAHPGC

ZNF384

366

Q8TF68
HTGERPYSCPHCPAR

ZBTB7B

396

O15156
PYSCPHCPARFLHSY

ZBTB7B

401

O15156
AHLTEPPNYCFHCSK

ZFP57

321

Q9NU63
APVCGFPCNHRHLFY

SPATA31A1

1241

Q5TZJ5
APVCGFPCNHRHLFY

SPATA31A5

1241

Q5VU36
FDPNCCFSIYHGSHR

PLCH2

116

O75038
YPCPDCGKAFRQSTH

ZNF574

766

Q6ZN55
HGDFVCHPRPCERYN

SUSD4

251

Q5VX71
CPYGSRCHFIHNPSE

ZFP36

156

P26651
SCVYIHPDSPNFGAH

TBXT

121

O15178
PHCKFHIYNGTRPCE

USP9Y

181

O00507
FHEQRSHCSPNPCFR

THBS3

271

P49746
HHLACLCPEGFTGLY

VASN

426

Q6EMK4
HQCPSCGRRFAYPSL

ZNF689

261

Q96CS4
HTGERPYPCSHCGRS

ZNF316

451

A6NFI3
PHNCRVCGRGFAYPS

ZNF366

336

Q8N895
HCVPDYHKQYAPRCS

ZYX

491

Q15942
PYPCHDCGKRFSNRS

ZNF835

361

Q9Y2P0
QPPLHCPFCDFTCRH

ZNF142

1421

P52746
CPYGPRCHFIHNADE

ZFP36L2

206

P47974
DECAYHHPISPCKAF

ZC3H14

611

Q6PJT7
YHPKHCRFNTQCTRP

ZC3H14

696

Q6PJT7
RAHTGEKPYPCSHCG

ZNF605

301

Q86T29
ACPPSFYGRNCEHDV

TDGF1P3

96

P51864
GSTRFECPHCHVPFG

ZNF296

441

Q8WUU4
HTGERPYACPHCSKA

ZNF358

341

Q9NW07
CGHSCPGPASLRAHY

ZNF784

106

Q8NCA9