Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-25 ERVK-9

1.05e-0937265GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-25 ERVK-9

1.21e-0938265GO:0070001
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-8 ERVK-6

8.90e-0511262GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-8 ERVK-6

1.47e-0414262GO:0003964
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-25 ERVK-9

2.05e-04430265GO:0004175
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-8 ERVK-6

3.37e-0421262GO:0035613
GeneOntologyMolecularFunctionzinc ion binding

ERVK-8 ERVK-6 ERVK-19 ERVK-9 HERC2 CREBBP

8.29e-04891266GO:0008270
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-8 ERVK-6

1.06e-0337262GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-8 ERVK-6

1.11e-0338262GO:0034061
GeneOntologyMolecularFunctionpeptidase activity

ERVK-8 ERVK-6 ERVK-19 ERVK-25 ERVK-9

1.38e-03654265GO:0008233
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-8 ERVK-6

1.63e-0346262GO:0016893
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-8 ERVK-6 ERVK-19 ERVK-9 HERC2 CREBBP

3.62e-031189266GO:0046914
GeneOntologyMolecularFunctioncatalytic activity, acting on DNA

ERVK-8 ERVK-6 RSF1

4.64e-03262263GO:0140097
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-8 ERVK-6

4.72e-0379262GO:0004521
GeneOntologyMolecularFunctionstructural molecule activity

ERVK-8 ERVK-6 ERVK-19 ERVK-25 ERVK-9

5.26e-03891265GO:0005198
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

ERVK-8 ERVK-6 LATS1 PFKM WNK2

6.53e-03938265GO:0016772
GeneOntologyBiologicalProcesscell-cell fusion

ERVK-8 ERVK-6 ERVK-19 ERVK-9

3.75e-0685264GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

ERVK-8 ERVK-6 ERVK-19 ERVK-9

3.75e-0685264GO:0000768
GeneOntologyBiologicalProcesssyncytium formation

ERVK-8 ERVK-6 ERVK-19 ERVK-9

4.50e-0689264GO:0006949
GeneOntologyBiologicalProcessviral process

ERVK-8 ERVK-6 ERVK-19 ERVK-9 CREBBP RSF1

1.97e-05464266GO:0016032
GeneOntologyBiologicalProcessDNA integration

ERVK-8 ERVK-6

1.18e-0413262GO:0015074
HumanPhenoProminent nasal septum

ATP6V1B2 CREBBP

1.27e-053112HP:0005322
HumanPhenoPolyhydramnios

SMG9 ATP6V1B2 HERC2 PRMT7 SLC16A2 CREBBP

1.79e-05312116HP:0001561
DomainZF_ZZ_2

HERC2 CREBBP

2.00e-0418222PS50135
DomainZF_ZZ_1

HERC2 CREBBP

2.00e-0418222PS01357
DomainZZ

HERC2 CREBBP

2.00e-0418222PF00569
DomainZnf_ZZ

HERC2 CREBBP

2.24e-0419222IPR000433
DomainZnF_ZZ

HERC2 CREBBP

2.24e-0419222SM00291
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-8 ERVK-6 ERVK-19 ERVK-9

1.92e-101229414557543
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-19 ERVK-9

1.04e-08629315063128
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-8 ERVK-6 ERVK-19 ERVK-25 ERVK-9

1.46e-089429521542922
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

6.71e-0722929060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

6.71e-0722929460924
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

2.01e-06329210516026
Pubmed

Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.

ERVK-6 ERVK-9

2.01e-0632929971820
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-19

4.02e-0642927983737
Pubmed

Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.

ATP6V1B2 CREBBP

4.02e-06429225713363
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-19

6.70e-06529212629516
Pubmed

Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway.

LATS1 CREBBP

6.70e-06529235349706
Pubmed

LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein.

LATS1 CREBBP

1.00e-05629233945069
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-19

3.01e-051029212970426
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-25 ERVK-9

1.02e-041829218664271
Pubmed

Identification of an imprinted gene cluster in the X-inactivation center.

SLC16A2 NEXMIF

1.40e-042129223940725
Pubmed

Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth.

CHCHD2 ATP6V1B2 CHCHD2P9

3.82e-0417029336470425
Pubmed

Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex targets ATXN1 to trigger NF-κB-dependent inflammation response.

DIAPH1 PRMT7 CREBBP

3.88e-0417129336629882
Pubmed

A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells.

ATXN2L RSF1

3.93e-043529229104064
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

DIAPH1 ATXN2L ATP6V1B2 LATS1 PFKM EIF4G2

4.91e-04124729627684187
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

ATXN2L PFKM WNK2 EIF4G2

5.13e-0445129436168627
Pubmed

Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.

CHCHD2 HERC2

5.39e-044129219343720
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

ATXN2L CREBBP NEXMIF

5.87e-0419729320811636
Pubmed

A human MAP kinase interactome.

LATS1 HERC2 CREBBP WNK2

6.78e-0448629420936779
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DIAPH1 HERC2 PFKM CREBBP RSF1 EIF4G2

7.54e-04135329629467282
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

PLPPR3 LATS1 AGAP9

7.87e-0421829333378226
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

HERC2 CREBBP

5.12e-051811291
GeneFamilyX-linked mental retardation|Angiotensin receptors

SLC16A2 NEXMIF

4.56e-0453112103
Diseasefrontotemporal dementia and/or amyotrophic lateral sclerosis-2 (implicated_via_orthology)

CHCHD2 CHCHD2P9

1.74e-063232DOID:0060214 (implicated_via_orthology)
Diseasespinal muscular atrophy, Jokela type (implicated_via_orthology)

CHCHD2 CHCHD2P9

1.74e-063232DOID:0081356 (implicated_via_orthology)
DiseaseParkinson's disease 22 (implicated_via_orthology)

CHCHD2 CHCHD2P9

1.74e-063232DOID:0080504 (implicated_via_orthology)
DiseaseLymphoma, Large-Cell, Follicular

ATP6V1B2 CREBBP

6.06e-0515232C0079745
DiseaseLymphoma, Small Cleaved-Cell, Follicular

ATP6V1B2 CREBBP

6.06e-0515232C0079765
DiseaseLymphoma, Mixed-Cell, Follicular

ATP6V1B2 CREBBP

6.06e-0515232C0079758
DiseaseLymphoma, Follicular, Grade 2

ATP6V1B2 CREBBP

6.06e-0515232C1956132
DiseaseLymphoma, Follicular, Grade 3

ATP6V1B2 CREBBP

6.06e-0515232C1956131
DiseaseLymphoma, Follicular, Grade 1

ATP6V1B2 CREBBP

6.06e-0515232C1956130
DiseaseLymphoma, Follicular

ATP6V1B2 CREBBP

1.09e-0420232C0024301
DiseaseParkinson's disease (implicated_via_orthology)

CHCHD2 CHCHD2P9 EIF4G2

2.42e-04157233DOID:14330 (implicated_via_orthology)
Diseasehandedness

ATXN2L RSF1

3.08e-03106232EFO_0009902
Diseaseskin pigmentation measurement

HERC2 CHCHD2P9

5.08e-03137232EFO_0007009
DiseaseHereditary hearing loss and deafness

DIAPH1 SUCLA2

5.75e-03146232cv:C0236038

Protein segments in the cluster

PeptideGeneStartEntry
MVVSLPMPAGAAAAN

ERVK-19

86

O71037
MVVSLPMPAGAAVAN

ERVK-8

86

Q902F8
MVVSLPMPAGAAAAN

ERVK-9

86

Q9UKH3
RMAGAPMAAAVQPAE

AGAP9

181

Q5VTM2
SMQAQAAVAGPRMPS

CREBBP

2041

Q92793
RAMDPAVPNMMIDAA

DIAPH1

246

O60610
MAAMDTGQRADPSNP

CCDC197

1

Q8NCU1
SAAAPRQPGLMAQMA

CHCHD2

46

Q9Y6H1
PMMQAAAAAGPPLVA

ATXN2L

766

Q8WWM7
MAPIAFELVGPMQAS

SLC16A2

431

P36021
AMMKNSVVRGPPAAG

PACRG

46

Q96M98
MAAAAARPINASMKP

LATS1

151

O95835
DAVVGALMPAAMIAP

HERC2

3411

O95714
AEAARSMARMPGPVP

EID2B

51

Q96D98
MNVGAPAAGMNAAVR

PFKM

406

P08237
MAAAVPKRMRGPAQA

KCT2

1

Q8NC54
VFIPAPMAQGMRSDF

EIF4G2

336

P78344
SAAAPRQPGLMAQMA

CHCHD2P9

46

Q5T1J5
MVVSLPMPAGAAAAN

ERVK-25

86

P61570
MVVSLPMPAGAAAAN

ERVK-6

86

Q69384
PGAMVMPQAASLHAV

PRMT7

506

Q9NVM4
MVVSLPMPAGAAAAN

HERVK_113

86

Q902F9
MATAAAAAAVMAPPG

RSF1

1

Q96T23
APFPAASMDAGMRRT

POM121L1P

351

Q3SYA9
MALRAMRGIVNGAAP

ATP6V1B2

1

P21281
APFAIMEPAGMSALN

NEXMIF

121

Q5QGS0
NRGMGTAAPAAMDPV

SMG9

151

Q9H0W8
AQAFMMAHPEPEGAV

SPATA25

181

Q9BR10
MGFPPNIVESAAENM

SUCLA2

226

Q9P2R7
MMAEKSGAAVANPPR

PLPPR3

521

Q6T4P5
EARAMTAPRAGVGMP

WNK2

2206

Q9Y3S1