Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	5-methylcytosine dioxygenase activity	TET1 TET3	1.26e-04	3	130	2	GO:0070579
GeneOntologyMolecularFunction	oxoglutarate dehydrogenase (succinyl-transferring) activity	OGDH OGDHL	2.50e-04	4	130	2	GO:0004591
GeneOntologyMolecularFunction	electron-transferring-flavoprotein dehydrogenase activity	ETFDH AIFM1	2.50e-04	4	130	2	GO:0004174
Domain	2-oxogl_dehyd_N	OGDH OGDHL	4.59e-05	2	127	2	IPR032106
Domain	2-oxogl_dehyd_N	OGDH OGDHL	4.59e-05	2	127	2	PF16078
Domain	Ankyrin_rpt	CDKN2D INHBC ANKMY1 MIB2 PSMD10 ANKHD1 TRANK1 ANKAR PPP1R16A	7.70e-05	262	127	9	IPR002110
Domain	2oxoglutarate_DH_E1	OGDH OGDHL	1.37e-04	3	127	2	IPR011603
Domain	KGD_C	OGDH OGDHL	1.37e-04	3	127	2	IPR031717
Domain	OxoGdeHyase_C	OGDH OGDHL	1.37e-04	3	127	2	PF16870
Domain	ANK	CDKN2D ANKMY1 MIB2 PSMD10 ANKHD1 TRANK1 ANKAR PPP1R16A	3.22e-04	251	127	8	SM00248
Domain	ANK_REPEAT	CDKN2D ANKMY1 MIB2 PSMD10 ANKHD1 TRANK1 ANKAR PPP1R16A	3.40e-04	253	127	8	PS50088
Domain	Ankyrin_rpt-contain_dom	CDKN2D ANKMY1 MIB2 PSMD10 ANKHD1 TRANK1 ANKAR PPP1R16A	3.49e-04	254	127	8	IPR020683
Domain	ANK_REP_REGION	CDKN2D ANKMY1 MIB2 PSMD10 ANKHD1 TRANK1 ANKAR PPP1R16A	3.49e-04	254	127	8	PS50297
Domain	NEUZ	NEURL1 NEURL4	4.53e-04	5	127	2	SM00588
Domain	Anaphylatoxin_comp_syst	C4A C4B	4.53e-04	5	127	2	IPR018081
Domain	NHR	NEURL1 NEURL4	4.53e-04	5	127	2	PS51065
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	4.53e-04	5	127	2	IPR001840
Domain	NHR_dom	NEURL1 NEURL4	4.53e-04	5	127	2	IPR006573
Domain	Neuralized	NEURL1 NEURL4	4.53e-04	5	127	2	PF07177
Domain	E1_dh	OGDH OGDHL	6.76e-04	6	127	2	PF00676
Domain	DH_E1	OGDH OGDHL	6.76e-04	6	127	2	IPR001017
Domain	ANATO	C4A C4B	9.42e-04	7	127	2	SM00104
Domain	ANAPHYLATOXIN_2	C4A C4B	9.42e-04	7	127	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	9.42e-04	7	127	2	PS01177
Domain	ANATO	C4A C4B	9.42e-04	7	127	2	PF01821
Domain	Anaphylatoxin/fibulin	C4A C4B	9.42e-04	7	127	2	IPR000020
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	1.25e-03	8	127	2	IPR019565
Domain	Transketolase-like_Pyr-bd	OGDH OGDHL	1.25e-03	8	127	2	IPR005475
Domain	Transket_pyr	OGDH OGDHL	1.25e-03	8	127	2	SM00861
Domain	Transket_pyr	OGDH OGDHL	1.25e-03	8	127	2	PF02779
Domain	Thiol-ester_cl	C4A C4B	1.25e-03	8	127	2	PF10569
Domain	MacrogloblnA2_CS	C4A C4B	1.25e-03	8	127	2	IPR019742
Domain	-	CDKN2D ANKMY1 MIB2 PSMD10 TRANK1 ANKAR PPP1R16A	1.55e-03	248	127	7	1.25.40.20
Domain	Sialidases	RELN SORCS1	1.60e-03	9	127	2	IPR011040
Domain	MIP_CS	AQP2 AQP3	1.99e-03	10	127	2	IPR022357
Domain	A2M	C4A C4B	1.99e-03	10	127	2	PF00207
Domain	A2M_N_2	C4A C4B	1.99e-03	10	127	2	IPR011625
Domain	A2M_comp	C4A C4B	1.99e-03	10	127	2	IPR011626
Domain	A2M_recep	C4A C4B	1.99e-03	10	127	2	PF07677
Domain	A2M_comp	C4A C4B	1.99e-03	10	127	2	PF07678
Domain	A2M_N	C4A C4B	1.99e-03	10	127	2	PF01835
Domain	A2M_N	C4A C4B	1.99e-03	10	127	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.99e-03	10	127	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.99e-03	10	127	2	PS00477
Domain	A2M_N_2	C4A C4B	1.99e-03	10	127	2	PF07703
Domain	Macroglobln_a2	C4A C4B	1.99e-03	10	127	2	IPR001599
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZXDC ARHGEF19 PDE2A EPPK1 SZT2 TMEM94 BICRA MTG2 GRK6 POMGNT1 MIB2 ANKHD1 FAAP100 ADAMTS7 ZNF341 NBEAL2 INTS11 NLRC5 OGDHL PPP1R16A	6.50e-09	1105	131	20	35748872
Pubmed	Complement component 4 variations may influence psychopathology risk in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.	CYP21A2 C4A C4B	5.22e-08	3	131	3	30465166
Pubmed	Complement 4 phenotypes and genotypes in Brazilian patients with classical 21-hydroxylase deficiency.	CYP21A2 C4A C4B	5.22e-08	3	131	3	19137635
Pubmed	Great genotypic and phenotypic diversities associated with copy-number variations of complement C4 and RP-C4-CYP21-TNX (RCCX) modules: a comparison of Asian-Indian and European American populations.	CYP21A2 C4A C4B	2.08e-07	4	131	3	19135723
Pubmed	Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp.	CYP21A2 C4A C4B	2.08e-07	4	131	3	3856857
Pubmed	Sequence of the gene for murine complement component C4.	CYP21A2 C4A C4B	2.08e-07	4	131	3	2777798
Pubmed	Two steroid 21-hydroxylase genes are located in the murine S region.	CYP21A2 C4A C4B	2.08e-07	4	131	3	6095106
Pubmed	The generation of thymus-independent germinal centers depends on CD40 but not on CD154, the T cell-derived CD40-ligand.	CD40LG C4A C4B	5.19e-07	5	131	3	16783845
Pubmed	A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis.	ICAM1 C4A C4B	5.19e-07	5	131	3	9382884
Pubmed	Mapping and sequencing analysis of the rat MHC.	CYP21A2 C4A C4B	5.19e-07	5	131	3	2652811
Pubmed	CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.	DCAF1 TET1 TET3	5.19e-07	5	131	3	25557551
Pubmed	Molecular map of the murine S region.	CYP21A2 C4A C4B	5.19e-07	5	131	3	6316336
Pubmed	Androgen-dependent hereditary mouse keratoconus: linkage to an MHC region.	CYP21A2 C4A C4B	1.04e-06	6	131	3	11773012
Pubmed	Molecular genetics of the human MHC complement gene cluster.	CYP21A2 C4A C4B	2.88e-06	8	131	3	10072631
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	EPPK1 RBL1 FKBP9 BOLA1 OGDH COG8 NOP9 CS C4A TOMM40 NEURL4	5.99e-06	533	131	11	25544563
Pubmed	Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.	ICAM1 AQP2 TET1 TET3	7.23e-06	33	131	4	36522157
Pubmed	Organizations and gene duplications of the human and mouse MHC complement gene clusters.	CYP21A2 C4A C4B	8.43e-06	11	131	3	10686478
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.41e-05	2	131	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.41e-05	2	131	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.41e-05	2	131	2	15998580
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.41e-05	2	131	2	19062096
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.41e-05	2	131	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.41e-05	2	131	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.41e-05	2	131	2	17645767
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.41e-05	2	131	2	12207352
Pubmed	Rhubarb tannins extract inhibits the expression of aquaporins 2 and 3 in magnesium sulphate-induced diarrhoea model.	AQP2 AQP3	1.41e-05	2	131	2	25215286
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.41e-05	2	131	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.41e-05	2	131	2	22387014
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.41e-05	2	131	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.41e-05	2	131	2	23918728
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.41e-05	2	131	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.41e-05	2	131	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.41e-05	2	131	2	4216347
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.41e-05	2	131	2	6950384
Pubmed	Aquaporins contribute to diarrhoea caused by attaching and effacing bacterial pathogens.	AQP2 AQP3	1.41e-05	2	131	2	16889624
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.41e-05	2	131	2	8660986
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.41e-05	2	131	2	8428773
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.41e-05	2	131	2	24638111
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.41e-05	2	131	2	21345967
Pubmed	Complement component 4 copy number variation and CYP21A2 genotype associations in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.	CYP21A2 C4A	1.41e-05	2	131	2	22886582
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.41e-05	2	131	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	1.41e-05	2	131	2	2302180
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.41e-05	2	131	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.41e-05	2	131	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.41e-05	2	131	2	29080553
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.41e-05	2	131	2	6589636
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.41e-05	2	131	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.41e-05	2	131	2	17728371
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.41e-05	2	131	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.41e-05	2	131	2	6149581
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.41e-05	2	131	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.41e-05	2	131	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.41e-05	2	131	2	2387317
Pubmed	Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral cancer cells.	ICAM1 PTGER1	1.41e-05	2	131	2	20647315
Pubmed	C4B null alleles are not associated with genetic polymorphisms in the adjacent gene CYP21A2 in autism.	CYP21A2 C4B	1.41e-05	2	131	2	18179706
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.41e-05	2	131	2	16908004
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.41e-05	2	131	2	7365238
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.41e-05	2	131	2	7391573
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.41e-05	2	131	2	17971360
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	1.41e-05	2	131	2	29928053
Pubmed	Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation.	TET1 TET3	1.41e-05	2	131	2	26711116
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	1.41e-05	2	131	2	17971229
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	1.41e-05	2	131	2	6881182
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	1.41e-05	2	131	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	1.41e-05	2	131	2	21880985
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	1.41e-05	2	131	2	6978711
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	1.41e-05	2	131	2	35898513
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	1.41e-05	2	131	2	28873507
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	1.41e-05	2	131	2	276882
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	1.41e-05	2	131	2	6832377
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	1.41e-05	2	131	2	3794341
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	1.41e-05	2	131	2	22785613
Pubmed	Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35.	CTDSP1 SLC11A1	1.41e-05	2	131	2	10967134
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	1.41e-05	2	131	2	32691186
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	1.41e-05	2	131	2	8390682
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	1.41e-05	2	131	2	3902619
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	1.41e-05	2	131	2	7373044
Pubmed	Distribution of AQP2 and AQP3 water channels in human tissue microarrays.	AQP2 AQP3	1.41e-05	2	131	2	15703994
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	1.41e-05	2	131	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	1.41e-05	2	131	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	1.41e-05	2	131	2	16098595
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	1.41e-05	2	131	2	15787745
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	1.41e-05	2	131	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	1.41e-05	2	131	2	6559257
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	1.41e-05	2	131	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	1.41e-05	2	131	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	1.41e-05	2	131	2	12480675
Pubmed	Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy.	AQP2 LNPEP	1.41e-05	2	131	2	33252660
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	1.41e-05	2	131	2	26800705
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	1.41e-05	2	131	2	15390104
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	1.41e-05	2	131	2	1699796
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	1.41e-05	2	131	2	2997024
Pubmed	Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.	TET1 TET3	1.41e-05	2	131	2	26703470
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	1.41e-05	2	131	2	3624865
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	1.41e-05	2	131	2	21857912
Pubmed	Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2.	GLI2 CD40LG	1.41e-05	2	131	2	28461568
Pubmed	Hypoxia Drives Breast Tumor Malignancy through a TET-TNFα-p38-MAPK Signaling Axis.	TET1 TET3	1.41e-05	2	131	2	26294212
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	1.41e-05	2	131	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	1.41e-05	2	131	2	4514997
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	1.41e-05	2	131	2	5919331
GeneFamily	Ankyrin repeat domain containing	CDKN2D ANKMY1 MIB2 PSMD10 ANKHD1 TRANK1 ANKAR PPP1R16A	1.82e-05	242	85	8	403
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	AQP3 C4A C4B	6.94e-04	37	85	3	454
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	7.70e-04	9	85	2	1234
GeneFamily	Zinc fingers CXXC-type	TET1 TET3	1.40e-03	12	85	2	136
GeneFamily	Aquaporins	AQP2 AQP3	1.92e-03	14	85	2	305
GeneFamily	Cadherin related	FAT2 CDHR4	2.84e-03	17	85	2	24
GeneFamily	Carboxypeptidases	CPD CPXM1	4.33e-03	21	85	2	1321
GeneFamily	PRAME family	PRAMEF5 PRAMEF6	5.64e-03	24	85	2	686
ToppCell	3'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPPK1 PAQR4 CA13 NBEAL2 NLRC5 OGDHL NEURL4	5.98e-07	165	131	7	34fd00be2b28716c871ad9fb356de84a299a0c01
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	COL6A3 ADGRV1 ARMC2 NOP9 ADAMTS7 HYAL3 SLC10A6	7.31e-07	170	131	7	ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell	TCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma-3\|TCGA-Cervix / Sample_Type by Project: Shred V9	ZXDC FAT2 MAST4 JMJD7 LNPEP SLC10A6	1.66e-06	122	131	6	1ed865f0ecfe304fb86313ff51c04e9052357270
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-Cd34+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 TRABD2B DRAM1 FKBP9 CPXM1 C4B STEAP1	1.71e-06	193	131	7	316ebdf15f75d88c348f909b643fcd315364ca84
ToppCell	droplet-Fat-Scat-18m-Mesenchymal-mesenchymal_stem_cell_of_adipose\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 TRABD2B DRAM1 FKBP9 CPXM1 C4B STEAP1	1.71e-06	193	131	7	1afdd3f7d703f4204a2cbfe40e135ac7b09213f7
ToppCell	droplet-Fat-Scat-18m-Mesenchymal\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A3 TRABD2B DRAM1 FKBP9 CPXM1 C4B STEAP1	1.71e-06	193	131	7	8dc6db335678f3a5cfd36026ad811fed8d9cb4bc
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6-Excitatory_Neuron.Slc17a7.Bcl6-Ptgfr_(Postsubiculum)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	HIPK4 PCDHA1 TIMM8A LIPM C4A	1.06e-05	98	131	5	9865a9de11dea6db0b75dd04fee523cd2da44766
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ECHDC3 HYAL3 PCIF1 SLX4IP CPXM1 PPP1R16A	1.20e-05	172	131	6	da959c1abadafd79b7a0088a25eb8ef8efa3a0c2
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 INHBC AQP2 MAST4 ADAMTS7 NEURL1	1.33e-05	175	131	6	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	B_cells-ISG-high_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	RTCB SOBP TRANK1 SLC15A2 APCDD1L HERC5	1.71e-05	183	131	6	dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_1-Mesothelial\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SLITRK1 LIPM CPXM1 C4A C4B STEAP1	1.88e-05	186	131	6	7812ed80d2378aca9957ef22fc3c8fb7fb58434b
ToppCell	facs-Lung-24m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A3 ARHGEF19 TRABD2B SOBP AQP2 CPXM1	1.88e-05	186	131	6	827f2f2ddde315d1e5970dd56f906c555ec699af
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A3 FKBP9 SLC10A6 CPXM1 C4B PRKG2	2.05e-05	189	131	6	e76dc36a01d8ad7590b3acc4c46abfcb76857448
ToppCell	droplet-Lung-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL6A3 FKBP9 SLC10A6 CPXM1 C4B PRKG2	2.11e-05	190	131	6	0b7200897b2c389632c9b1ee37e272b811555dbc
Disease	oxoglutarate dehydrogenase deficiency (implicated_via_orthology)	OGDH OGDHL	1.75e-05	2	124	2	DOID:0081326 (implicated_via_orthology)
Disease	Graves' disease (is_implicated_in)	ICAM1 CD40LG C4A C4B	2.18e-05	39	124	4	DOID:12361 (is_implicated_in)
Disease	phospholipids:total lipids ratio	INHBC ETFDH ADH4 CEACAM19 PCIF1 NLRC5 TOMM40	5.10e-05	227	124	7	EFO_0020946
Disease	neutrophil measurement	CDKN2D EPPK1 ICAM1 FAT2 HYAL3 SLC23A2	1.06e-04	177	124	6	EFO_0803548
Disease	triglycerides to total lipids in large HDL percentage	INHBC ETFDH PCIF1 NLRC5	1.21e-04	60	124	4	EFO_0022330
Disease	sexual dimorphism measurement	EPPK1 DRAM1 RBL1 ETFDH CTDSP1 CPD ARMC2 TRANK1 ZNF341 GLI2 PCIF1 NLRC5 TOMM40 PRKG2	2.34e-04	1106	124	14	EFO_0021796
Disease	Treacher Collins syndrome (implicated_via_orthology)	EFTUD2 POLR1B	2.60e-04	6	124	2	DOID:2908 (implicated_via_orthology)
Disease	cystatin C measurement	ERBB4 DCDC1 CYP21A2 GRK6 ADGRV1 PTGER1 SLX4IP TOMM40	3.08e-04	402	124	8	EFO_0004617
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	CYP21A2 ETFDH OGDH NPC1L1 PCIF1	3.65e-04	144	124	5	EFO_0004611, EFO_0020943
Disease	cholesteryl esters to total lipids in very large HDL percentage	CEACAM19 PCIF1 NLRC5	4.67e-04	36	124	3	EFO_0022257
Disease	chronic kidney disease	COL6A3 DCDC1 INHBC CYP21A2 ETFDH TET3	4.89e-04	235	124	6	EFO_0003884
Disease	nephrogenic diabetes insipidus (implicated_via_orthology)	AQP2 AQP3	7.71e-04	10	124	2	DOID:12387 (implicated_via_orthology)
Disease	allergic disease	DCAF1 PLB1 PRXL2B AQP2 PHYH SLC15A2	7.96e-04	258	124	6	MONDO_0005271
Disease	free cholesterol to total lipids in small HDL percentage	ETFDH PCIF1 TOMM40	1.30e-03	51	124	3	EFO_0022285
Disease	pre-eclampsia (implicated_via_orthology)	ICAM1 CD40LG	1.33e-03	13	124	2	DOID:10591 (implicated_via_orthology)
Disease	white matter microstructure measurement	EPPK1 DCDC1 DRAM1 PCDHA1 ANKHD1 EFTUD2 MAST4	1.34e-03	390	124	7	EFO_0005674
Disease	cholesterol in small VLDL measurement	CEACAM19 PCIF1 TOMM40	1.46e-03	53	124	3	EFO_0022228
Disease	cholesterol to total lipids in large HDL percentage	ETFDH CEACAM19 PCIF1	1.62e-03	55	124	3	EFO_0022234
Disease	triglycerides to total lipids in medium HDL percentage	INHBC PCIF1 NLRC5	1.71e-03	56	124	3	EFO_0022333
Disease	sleep duration, high density lipoprotein cholesterol measurement	TMEM94 PCIF1 NLRC5 TOMM40	1.73e-03	121	124	4	EFO_0004612, EFO_0005271
Disease	pyroglutamine measurement	RELN CYP21A2 SORCS1	1.89e-03	58	124	3	EFO_0005408
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	INHBC ETFDH ADH4 PCIF1 NLRC5 TOMM40	1.93e-03	307	124	6	EFO_0004612, EFO_0020946
Disease	Malignant neoplasm of skin	ERBB4 AQP3 GLI2	1.98e-03	59	124	3	C0007114
Disease	cholesteryl esters to total lipids in large HDL percentage	INHBC ETFDH PCIF1	1.98e-03	59	124	3	EFO_0022248
Disease	Skin Neoplasms	ERBB4 AQP3 GLI2	1.98e-03	59	124	3	C0037286
Disease	Disorder of eye	ADGRV1 TIMM8A PHYH ROM1 SNRNP200	2.06e-03	212	124	5	C0015397
Disease	cholesterol to total lipids in medium HDL percentage	INHBC PCIF1 NLRC5	2.08e-03	60	124	3	EFO_0022237
Disease	cholesteryl ester measurement, high density lipoprotein cholesterol measurement	INHBC CYP21A2 ETFDH ADH4 PCIF1 NLRC5	2.10e-03	312	124	6	EFO_0004612, EFO_0010351
Disease	total cholesterol measurement, high density lipoprotein cholesterol measurement	INHBC CYP21A2 ETFDH ADH4 PCIF1 NLRC5	2.20e-03	315	124	6	EFO_0004574, EFO_0004612
Disease	muscular dystrophy (is_implicated_in)	COL6A3 POMGNT1	2.29e-03	17	124	2	DOID:9884 (is_implicated_in)
Disease	Huntington Disease	RELN AIFM1	2.29e-03	17	124	2	C0020179
Disease	systemic lupus erythematosus (is_implicated_in)	SLC11A1 C4A C4B	2.29e-03	62	124	3	DOID:9074 (is_implicated_in)
Disease	phospholipid measurement, high density lipoprotein cholesterol measurement	INHBC CYP21A2 ETFDH ADH4 PCIF1 NLRC5	2.41e-03	321	124	6	EFO_0004612, EFO_0004639
Disease	glycine measurement	ERBB4 CYP21A2 GRK6 ADGRV1	2.71e-03	137	124	4	EFO_0009767
Disease	lipid measurement, high density lipoprotein cholesterol measurement	INHBC CYP21A2 ETFDH ADH4 PCIF1 NLRC5	2.77e-03	330	124	6	EFO_0004529, EFO_0004612
Disease	body mass index, high density lipoprotein cholesterol measurement	INHBC TOMM40	2.86e-03	19	124	2	EFO_0004340, EFO_0004612
Disease	inflammatory bowel disease (is_implicated_in)	ICAM1 SLC11A1	2.86e-03	19	124	2	DOID:0050589 (is_implicated_in)
Disease	triglyceride measurement, body mass index	INHBC TOMM40	2.86e-03	19	124	2	EFO_0004340, EFO_0004530
Disease	HIV-1 infection, Susceptibility to viral and mycobacterial infections	BICRA PRKG2	3.49e-03	21	124	2	EFO_0000180, Orphanet_391311
Disease	triglycerides to total lipids in small HDL percentage	INHBC PCIF1 NLRC5	3.50e-03	72	124	3	EFO_0022336
Disease	non-small cell lung carcinoma	MIER2 CYP21A2 AQP3	3.92e-03	75	124	3	EFO_0003060

Protein segments in the cluster

Peptide	Gene	Start	Entry
QHARTPLIAAGVIGG	ERBB4	646	Q15303
LPAGVLREGAVQFLH	DCANP1	76	Q8TF63
GAVAGAALLHEITPA	AQP2	96	P41181
QSIHLGGVFELQPGA	CD40LG	221	P29965
VHLGVPLSVGVQLQD	C4B	31	P0C0L5
LAFPVIVGHEAAGIV	ADH4	61	P08319
DLPHIENGGVAVLTG	AIFM1	216	O95831
ALLEAAGPSHVAINA	AKAP10	61	O43572
LANIAIHPGVGPVLA	ARMC2	611	Q8NEN0
TPASGIAHILLIGQD	ADGRV1	3511	Q8WXG9
VLVLLGAHTAPAAGE	APCDD1L	11	Q8NCL9
LGIADAVIAVDGINH	CPXM1	636	Q96SM3
AHEPDGLAVLGVFLQ	CA13	136	Q8N1Q1
ELGGPVHALAIQART	BOLA1	96	Q9Y3E2
NVPDGTGALPIHLAV	CDKN2D	101	P55273
QGAILVHSDLVLGPF	CDHR4	601	A6H8M9
AALDIVHPVRVDAGG	ADAMTS7	41	Q9UKP4
HFAAVLLDGGPLVGI	OR7A2P	201	Q8NGA2
QGIPGHVFLLQLLHG	ARHGEF19	661	Q8IW93
VHALVEAGGIPSLIN	ANKAR	776	Q7Z5J8
LAVPVVHDGGALLAF	DRAM1	116	Q8N682
NISGVFHPNGLEVII	DCAF1	1261	Q9Y4B6
DGQIISHAAPQLVLG	DCDC1	1171	M0R2J8
PVLEAVLAQGHPGVV	NOP9	391	Q86U38
VLAQGHPGVVIALVG	NOP9	396	Q86U38
LVGQAEPESVLLVHG	INTS11	401	Q5TA45
GEHLGASAEPLAILQ	HIPK4	526	Q8NE63
RPVVLLQHGLVGGAS	LIPM	91	Q5VYY2
VALPGGEHAENAVQI	LRRTM1	411	Q86UE6
VAVGHLEVPAELAGL	MYO15A	1996	Q9UKN7
FVLDVLEGRAQHPGV	JMJD7	111	P0C870
LQHLHGVPQGALLED	INHBC	76	P55103
NILADALGPGVVGIH	APH1A	136	Q96BI3
LDAVIGFNGHVPTGL	CFAP52	16	Q8N1V2
GTVIIPNLQGAHLDE	CYP21A2	381	P08686
GEPISAQEALLHGLL	ECHDC3	206	Q96DC8
FGSLAALVVHVEPAL	FAT2	236	Q9NYQ8
IHLASLQPAEAVAGV	FAT2	3666	Q9NYQ8
SEGLILQLVGDAVHP	ISOC2	161	Q96AB3
LGVQAARLLAAHDVP	OGDHL	11	Q9ULD0
EIRIPADQGIAGHVA	PDE2A	456	O00408
LATDLAGHVIPGALV	PTGER1	81	P34995
AHSGAPLLVEENGAI	CTDSP1	56	Q9GZU7
GHVNIGAIQEPLAFI	COG8	541	Q96MW5
GQIAIVAPEALLAGH	LNPEP	241	Q9UIQ6
CGHPELLQAVGIVGA	SLC11A1	236	P49279
AAAAVAAQGVPQHLL	GLI2	41	P10070
GVAPDGANVHLIVRE	FAAP100	756	Q0VG06
PHGILILGQEQDTLG	NPTXR	416	O95502
PGNHIFVLAEGRLEV	PRKG2	201	Q13237
AGVQHLATILPGLPE	NLRC5	1621	Q86WI3
LSVGSILQLHAGVVP	PAQR4	246	Q8N4S7
EQGEVLISLHIAGNP	RELN	51	P78509
AVSELVPRLVGAGHV	PCDHA1	576	Q9Y5I3
EHLAGVPLAQISAGE	HERC5	186	Q9UII4
LDITFHLLEPGQAVG	NPC1L1	216	Q9UHC9
RGNIPGSAVLVFDIH	FKBP9	346	O95302
GHHVAQLDPLGILDA	OGDH	141	Q02218
HLNEGEPLVALGLVV	ETFDH	311	Q16134
GLRHLPVVNAVGEIV	CLCN6	831	P51797
VLGQHDVISDPLGLN	PCIF1	76	Q9H4Z3
EFGVETLGPLVAQLH	GLT6D1	181	Q7Z4J2
LAGPLHGLANQEVLV	CS	296	O75390
GAAVRLHLELGQPAA	F8A1;	126	P23610
IEDGVPQHLVLVLGG	COL6A3	1536	P12111
FGVHLPLNALGIIAN	HYAL3	46	O43820
AGIHGNAPVGTELLL	CPD	991	O75976
LLAPGVHNIIAIADG	CPD	1251	O75976
LHIAAALPGEEGVQI	ANKMY1	586	Q9P2S6
HLPTNAGILAATIIG	CEACAM19	151	Q7Z692
GDLITHINGEPVHGL	MAST4	1191	O15021
VALGVIAGGIRHIPD	ME3	496	Q16798
GLFPVSEAQVHLALG	ICAM1	241	P05362
VAQSGPALGEALPHV	DNAAF5	591	Q86Y56
GIVPEANDGHLATLL	ENPP7	396	Q6UWV6
RISDLGLAVHVPEGQ	GRK6	326	P43250
QILAAAAPHTGGQLI	BICRA	496	Q9NZM4
GALPILGGQVVHTVL	SLC15A2	131	Q16348
GVGSGHLNIPLILEE	SALL2	171	Q9Y467
LHLHVNGVDQGVAVP	NEURL4	1256	Q96JN8
VHLGVPLSVGVQLQD	C4A	31	P0C0L4
LEVGDNHLVFVAPGA	LINGO4	161	Q6UY18
LIGIGDVNPFLAAHP	MIER2	511	Q8N344
GHTEIVEFLLQLGVP	PSMD10	51	O75832
EHPGRLVVEVALGNA	MIB2	431	Q96AX9
QIVLGHLGRPSAGAV	PHYH	11	O14832
LDQHGVRLVGVGPEA	PRXL2B	61	Q8TBF2
NVAALPGIVHRSIGL	RTCB	71	Q9Y3I0
GQILIADLRGHEGPV	SEC13	46	P55735
SLHGLDINQEPIIFG	SYDE2	801	Q5VT97
LLVHGVGQAGPEITD	SZT2	2161	Q5T011
VLIGGNHLITAGVPR	ARHGAP11A	386	Q6P4F7
APENEGRLVHIIGAL	TMEM43	81	Q9BTV4
AGLGADVALLQLEPH	PRSS29P	156	A6NIE9
AGALAPAHISGLVLE	PKNOX1	416	P55347
PLHGVANDAGEITLI	RBL1	721	P28749
DVVALFGLRGIQHTP	POMGNT1	346	Q8WZA1
PIFHLALGSEGQIVV	NBEAL2	2601	Q6ZNJ1
LEAQIATGGIIDPVH	EPPK1	1681	P58107
HAAGALGLPDLVAVL	EPPK1	3211	P58107
QHAAGALGLPDLVAV	EPPK1	4811	P58107
GQVPLVELLVAHGAD	PPP1R16A	276	Q96I34
HLQIAVADIPGIIRG	MTG2	271	Q9H4K7
GNGVVIHLPGLFEEA	ADSS2	96	P30520
HALRPADIQVVAALG	PLB1	731	Q6P1J6
GNFAVLVDLHILPQG	SLX4IP	11	Q5VYV7
LPGVIAAIVQLHNGT	STEAP1	131	Q9UHE8
AVQGAIQILPLGSGH	TET1	461	Q8NFU7
FLDANIGGVAIAPAH	TET1	2001	Q8NFU7
IGGVAIAPAHGSVLI	TET1	2006	Q8NFU7
IAITGHDQGLLVQEP	ANKHD1	966	Q8IWZ3
PLILAATAGHVGVVE	ANKHD1	1091	Q8IWZ3
ILIAGQVSGAHLNPA	AQP3	71	Q92482
VQAVILGDNITGHLP	CLEC4F	71	Q8N1N0
VLDGLDALLTQGVHP	PRAMEF6	81	Q5VXH4
VPFILLGDIQEPGHA	WFDC6	11	Q9BQY6
VVPGHAEGLGSNLAL	ZNF341	816	Q9BYN7
LVLLEVPHGGAAAEA	ZXDC	76	Q2QGD7
GPLHSGDILGLVVNA	NEURL1	391	O76050
NNGLHEIVPGAFLGL	SLITRK1	91	Q96PX8
VLPQAALAAGAVALG	ROM1	61	Q03395
PIHAINRGIFVEGLS	SLC23A2	411	Q9UGH3
DGHLVNLPVSLLVEG	TMEM94	171	Q12767
ILRQAGLEVDHTPAG	TRABD2B	341	A6NFA1
LQGPQDGVIDLTVGH	SOBP	646	A7XYQ1
AIIDGANITLPHGAL	UBTD2	91	Q8WUN7
VLDGLDALLTQGVHP	PRAMEF5	81	Q5TYX0
PVGLEVHGNLELVFT	SLC10A6	21	Q3KNW5
VAEHGARFQIPLLGA	TIGIT	131	Q495A1
LSPGAGAQQLEVVHL	nan	66	A8MTW9
IGGVAVAPAHGSILI	TET3	1651	O43151
AVPVGAAHLLVPGLQ	IGSF9	561	Q9P2J2
GNPDVLVGSGILVAH	TOMM40	206	O96008
VHLIGGENGPVLEVI	SNRNP200	1456	O75643
VRAELQGHLGPVTAV	WDR27	156	A2RRH5
HAQVGLGALQLVPDD	TRANK1	746	O15050
ILDAVVAQEPLHRGG	EFTUD2	791	Q15029
HEGLGLAVQAIPPFE	POLR1B	51	Q9H9Y6
EATGVPGQHILVAVL	SORCS1	1011	Q8WY21
GLGAVDPQLQHFIEV	TIMM8A	11	O60220
GPGIVHLLQEAAEGA	MYT1	191	Q01538