Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	PH_dom-like	LDLRAP1 RANBP2 FRMPD4 RASGRF2 EPB41L4B DOCK11 FRMPD1 ECT2L ARHGEF25 ARHGEF16 PTK2B GRK3 AGAP9 PLCH1 DCP1A PLCE1	2.92e-08	426	126	16	IPR011993
Domain	-	LDLRAP1 RANBP2 RASGRF2 EPB41L4B DOCK11 ECT2L ARHGEF25 ARHGEF16 GRK3 AGAP9 PLCH1 DCP1A PLCE1	2.45e-06	391	126	13	2.30.29.30
Domain	ARM-type_fold	STK36 CAND1 ARMC3 DOCK11 LRRK2 APOB IPO9 MROH1 ARID2 AP3B2	1.02e-04	339	126	10	IPR016024
Domain	LRR_1	LRRK2 CPN2 TLR2 SLITRK5 KDM2A LRRC8B LGR6 LRRD1	1.21e-04	219	126	8	PF00560
Domain	Vitellinogen_superhlx	CAND1 APOB	1.35e-04	3	126	2	IPR011030
Domain	LRR_8	LRRK2 CPN2 TLR2 SLITRK5 LRRC8B LGR6 LRRD1	1.61e-04	171	126	7	PF13855
Domain	LRR_TYP	LRRK2 CPN2 TLR2 SLITRK5 LRRC8B LGR6 LRRD1	2.00e-04	177	126	7	SM00369
Domain	Leu-rich_rpt_typical-subtyp	LRRK2 CPN2 TLR2 SLITRK5 LRRC8B LGR6 LRRD1	2.00e-04	177	126	7	IPR003591
Domain	FERM_M	FRMPD4 EPB41L4B FRMPD1 PTK2B	2.59e-04	46	126	4	PF00373
Domain	-	FRMPD4 EPB41L4B FRMPD1 PTK2B	3.31e-04	49	126	4	1.20.80.10
Domain	FERM_central	FRMPD4 EPB41L4B FRMPD1 PTK2B	3.31e-04	49	126	4	IPR019748
Domain	FERM_domain	FRMPD4 EPB41L4B FRMPD1 PTK2B	3.31e-04	49	126	4	IPR000299
Domain	FERM/acyl-CoA-bd_prot_3-hlx	FRMPD4 EPB41L4B FRMPD1 PTK2B	3.58e-04	50	126	4	IPR014352
Domain	FERM_1	FRMPD4 EPB41L4B FRMPD1 PTK2B	3.58e-04	50	126	4	PS00660
Domain	FERM_2	FRMPD4 EPB41L4B FRMPD1 PTK2B	3.58e-04	50	126	4	PS00661
Domain	FERM_3	FRMPD4 EPB41L4B FRMPD1 PTK2B	3.58e-04	50	126	4	PS50057
Domain	Band_41_domain	FRMPD4 EPB41L4B FRMPD1 PTK2B	3.58e-04	50	126	4	IPR019749
Domain	B41	FRMPD4 EPB41L4B FRMPD1 PTK2B	3.58e-04	50	126	4	SM00295
Domain	LRR	LRRK2 CPN2 TLR2 SLITRK5 LRRC8B LGR6 LRRD1	4.32e-04	201	126	7	PS51450
Domain	VWA_2	INTS6L PSMD4	4.46e-04	5	126	2	PF13519
Domain	ARM-like	STK36 CAND1 ARMC3 LRRK2 IPO9 MROH1 ARID2 AP3B2	4.97e-04	270	126	8	IPR011989
Domain	Leu-rich_rpt	LRRK2 CPN2 TLR2 SLITRK5 KDM2A LRRC8B LGR6 LRRD1	5.09e-04	271	126	8	IPR001611
Domain	Haem_d1	EML6 KMT2A	6.65e-04	6	126	2	IPR011048
Domain	Ser/Thr_kinase_AS	STK36 STK17A LRRK2 MAP3K12 CDK10 CHUK STK11 MAST4 GRK3	7.13e-04	357	126	9	IPR008271
Domain	S_TKc	STK36 STK17A LRRK2 MAP3K12 CDK10 CHUK STK11 MAST4 GRK3	7.42e-04	359	126	9	SM00220
Domain	-	STK36 CAND1 ARMC3 LRRK2 IPO9 MROH1 AP3B2	7.79e-04	222	126	7	1.25.10.10
Domain	PROTEIN_KINASE_ST	STK36 STK17A LRRK2 MAP3K12 CDK10 CHUK STK11 MAST4 GRK3	7.87e-04	362	126	9	PS00108
Domain	DH_1	RASGRF2 ECT2L ARHGEF25 ARHGEF16	8.65e-04	63	126	4	PS00741
Domain	EGF_LAM_2	LAMB4 STAB2 LAMC3	1.07e-03	30	126	3	PS50027
Domain	EGF_LAM_1	LAMB4 STAB2 LAMC3	1.07e-03	30	126	3	PS01248
Domain	PROTEIN_KINASE_ATP	STK36 STK17A LRRK2 MAP3K12 CDK10 CHUK PTK2B STK11 MAST4 GRK3	1.11e-03	459	126	10	PS00107
Domain	Kinase-like_dom	STK36 STK17A LRRK2 ARHGAP35 MAP3K12 CDK10 CHUK PTK2B STK11 MAST4 GRK3	1.12e-03	542	126	11	IPR011009
Domain	RhoGEF	RASGRF2 ECT2L ARHGEF25 ARHGEF16	1.15e-03	68	126	4	SM00325
Domain	RhoGEF	RASGRF2 ECT2L ARHGEF25 ARHGEF16	1.28e-03	70	126	4	PF00621
Domain	DH_2	RASGRF2 ECT2L ARHGEF25 ARHGEF16	1.28e-03	70	126	4	PS50010
Domain	-	RASGRF2 ECT2L ARHGEF25 ARHGEF16	1.35e-03	71	126	4	1.20.900.10
Domain	DH-domain	RASGRF2 ECT2L ARHGEF25 ARHGEF16	1.35e-03	71	126	4	IPR000219
Domain	-	LRRK2 CPN2 TLR2 SLITRK5 KDM2A LRRC8B LGR6 LRRD1	1.52e-03	321	126	8	3.80.10.10
Domain	-	INTS6L PSMD4 VIT MDN1	1.58e-03	74	126	4	3.40.50.410
Domain	EGF_Lam	LAMB4 STAB2 LAMC3	1.68e-03	35	126	3	SM00180
Domain	L_dom-like	LRRK2 CPN2 TLR2 SLITRK5 KDM2A LRRC8B LGR6 LRRD1	1.74e-03	328	126	8	IPR032675
Domain	Prot_kinase_dom	STK36 STK17A LRRK2 MAP3K12 CDK10 CHUK PTK2B STK11 MAST4 GRK3	1.77e-03	489	126	10	IPR000719
Domain	PROTEIN_KINASE_DOM	STK36 STK17A LRRK2 MAP3K12 CDK10 CHUK PTK2B STK11 MAST4 GRK3	1.88e-03	493	126	10	PS50011
Domain	Laminin_EGF	LAMB4 STAB2 LAMC3	2.13e-03	38	126	3	IPR002049
Domain	VWFA	INTS6L PSMD4 VIT MDN1	2.30e-03	82	126	4	PS50234
Domain	ZF_CXXC	KMT2A KDM2A	2.39e-03	11	126	2	PS51058
Domain	Znf_CXXC	KMT2A KDM2A	2.39e-03	11	126	2	IPR002857
Domain	zf-CXXC	KMT2A KDM2A	2.39e-03	11	126	2	PF02008
Domain	VWA	INTS6L PSMD4 VIT MDN1	2.51e-03	84	126	4	SM00327
Domain	PH	RASGRF2 DOCK11 ARHGEF25 ARHGEF16 GRK3 AGAP9 PLCH1	2.81e-03	278	126	7	SM00233
Domain	PH_DOMAIN	RASGRF2 DOCK11 ARHGEF25 ARHGEF16 GRK3 AGAP9 PLCH1	2.87e-03	279	126	7	PS50003
Domain	PH_domain	RASGRF2 DOCK11 ARHGEF25 ARHGEF16 GRK3 AGAP9 PLCH1	2.93e-03	280	126	7	IPR001849
Domain	PHD	KDM5D KMT2A KDM2A RAI1	3.10e-03	89	126	4	SM00249
Domain	Znf_PHD	KDM5D KMT2A KDM2A RAI1	3.36e-03	91	126	4	IPR001965
Domain	ZF_PHD_2	KDM5D KMT2A KDM2A RAI1	3.92e-03	95	126	4	PS50016
Domain	ZF_PHD_1	KDM5D KMT2A KDM2A RAI1	4.07e-03	96	126	4	PS01359
Domain	HEAT	STK36 CAND1 MROH1	4.16e-03	48	126	3	PF02985
Domain	Protein_kinase_ATP_BS	STK36 STK17A LRRK2 CDK10 CHUK PTK2B STK11 GRK3	4.20e-03	379	126	8	IPR017441
Domain	Pkinase	STK36 STK17A LRRK2 CDK10 CHUK STK11 MAST4 GRK3	4.34e-03	381	126	8	PF00069
Domain	-	KDM5D ARID2	4.48e-03	15	126	2	1.10.150.60
Domain	BRIGHT	KDM5D ARID2	4.48e-03	15	126	2	SM00501
Domain	EF-hand_like	PLCH1 PLCE1	4.48e-03	15	126	2	PF09279
Domain	ARID_dom	KDM5D ARID2	4.48e-03	15	126	2	IPR001606
Domain	ARID	KDM5D ARID2	4.48e-03	15	126	2	PS51011
Domain	PI-PLC-Y	PLCH1 PLCE1	4.48e-03	15	126	2	PF00387
Domain	PLCYc	PLCH1 PLCE1	4.48e-03	15	126	2	SM00149
Domain	PLipase_C_Pinositol-sp_Y	PLCH1 PLCE1	4.48e-03	15	126	2	IPR001711
Domain	PIPLC_Y_DOMAIN	PLCH1 PLCE1	4.48e-03	15	126	2	PS50008
Domain	ARID	KDM5D ARID2	4.48e-03	15	126	2	PF01388
Domain	PI-PLC_fam	PLCH1 PLCE1	4.48e-03	15	126	2	IPR001192
Domain	PLC_EF-hand-like	PLCH1 PLCE1	4.48e-03	15	126	2	IPR015359
Domain	VWF_A	INTS6L PSMD4 VIT MDN1	4.54e-03	99	126	4	IPR002035
Domain	Laminin_N	LAMB4 LAMC3	5.09e-03	16	126	2	IPR008211
Domain	LamNT	LAMB4 LAMC3	5.09e-03	16	126	2	SM00136
Domain	LAMININ_NTER	LAMB4 LAMC3	5.09e-03	16	126	2	PS51117
Domain	Laminin_N	LAMB4 LAMC3	5.09e-03	16	126	2	PF00055
Domain	LRRNT	CPN2 SLITRK5 LGR6	5.49e-03	53	126	3	PF01462
Domain	MFS	SLC17A3 SVOPL SLC22A16 SLC17A1	6.17e-03	108	126	4	PS50850
Domain	PI-PLC-X	PLCH1 PLCE1	6.44e-03	18	126	2	PF00388
Domain	PLCXc	PLCH1 PLCE1	6.44e-03	18	126	2	SM00148
Pubmed	Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset.	BTN3A2 BTN3A1 BTN3A3	4.99e-08	3	129	3	22767497
Pubmed	Common variants on chromosome 6p22.1 are associated with schizophrenia.	SLC17A3 BTN3A2 BTN3A1 SLC17A1	5.84e-08	11	129	4	19571809
Pubmed	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	STK17A NCOA4 TRIP11 MAP3K12 STAT3 TG PAX8	9.19e-08	99	129	7	19730683
Pubmed	Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2.	BTN3A2 BTN3A1 BTN3A3	1.99e-07	4	129	3	39142074
Pubmed	Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology.	BTN3A2 BTN3A1 BTN3A3	4.96e-07	5	129	3	29339503
Pubmed	A 1.1-Mb transcript map of the hereditary hemochromatosis locus.	SLC17A3 BTN3A2 BTN3A1 BTN3A3	5.31e-07	18	129	4	9149941
Pubmed	The cluster of BTN genes in the extended major histocompatibility complex.	BTN3A2 BTN3A1 BTN3A3	1.73e-06	7	129	3	11170752
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FOXJ2 RANBP2 IQGAP2 FRMPD1 PSMD8 NR3C1 STAT3 CHUK IARS2 ZC3H11A MDN1 KDM2A CDC25A DCP1A	3.90e-06	857	129	14	25609649
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RANBP2 ARMC3 IQGAP2 RBBP8 EML6 PSMD8 APOB TMEM43 DNTTIP2 CHUK STK11 MDN1 KMT2A PLCH1 USPL1 POLQ RAI1 ZNF292	6.61e-06	1442	129	18	35575683
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	LDLRAP1 CAND1 NELFA PSMD4 EDC4 PAPSS2 MTFMT ZC3H11A IPO9 COQ4 SGPL1 ARID2 KMT2A KDM2A CDC25A RBM18 ZNF292	8.74e-06	1327	129	17	32694731
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	RANBP2 CAND1 PSMD4 EDC4 NR3C1 ARHGAP35 TRIP11 DNTTIP2 STAT3 IARS2 ZC3H11A ARID2 KMT2A DCP1A	1.03e-05	934	129	14	33916271
Pubmed	The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome.	NR3C1 STAT3	1.37e-05	2	129	2	22633955
Pubmed	Hepatic ABCA1 deficiency is associated with delayed apolipoprotein B secretory trafficking and augmented VLDL triglyceride secretion.	ABCA1 APOB	1.37e-05	2	129	2	28694219
Pubmed	Knockdown of PLCε inhibits inflammatory cytokine release via STAT3 phosphorylation in human bladder cancer cells.	STAT3 PLCE1	1.37e-05	2	129	2	26156799
Pubmed	Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells.	TERT STAT3	1.37e-05	2	129	2	24386318
Pubmed	[Leptin promotes the expression of hTERT via STAT3 in breast cancer cells].	TERT STAT3	1.37e-05	2	129	2	23158658
Pubmed	KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway.	TERT KMT2A	1.37e-05	2	129	2	28726783
Pubmed	Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway.	STAT3 STK11	1.37e-05	2	129	2	23526220
Pubmed	SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans.	SLC17A3 SLC17A1	1.37e-05	2	129	2	39134528
Pubmed	[Effect of transfection of LKB1 on biological behavior of human lung adenocarcinoma cells].	STAT3 STK11	1.37e-05	2	129	2	19068194
Pubmed	Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation.	PSMD4 PSMD8	1.37e-05	2	129	2	22906049
Pubmed	STAT3 and GR Cooperate to Drive Gene Expression and Growth of Basal-Like Triple-Negative Breast Cancer.	NR3C1 STAT3	1.37e-05	2	129	2	32816914
Pubmed	Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway.	STAT3 MVP	1.37e-05	2	129	2	31092229
Pubmed	Downregulation of LKB1 suppresses Stat3 activity to promote the proliferation of esophageal carcinoma cells.	STAT3 STK11	1.37e-05	2	129	2	24676538
Pubmed	PAX8 expression and TERT promoter mutations in the nested variant of urothelial carcinoma: a clinicopathologic study with immunohistochemical and molecular correlates.	TERT PAX8	1.37e-05	2	129	2	31932679
Pubmed	STAT3 acts as a co-activator of glucocorticoid receptor signaling.	NR3C1 STAT3	1.37e-05	2	129	2	9388192
Pubmed	Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression.	NR3C1 ARHGAP35	1.37e-05	2	129	2	1894621
Pubmed	VGLL4 interacts with STAT3 to function as a tumor suppressor in triple-negative breast cancer.	STAT3 VGLL4	1.37e-05	2	129	2	31748508
Pubmed	Differential role for CD277 as a co-regulator of the immune signal in T and NK cells.	BTN3A2 BTN3A1	1.37e-05	2	129	2	21918970
Pubmed	STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway.	STAT3 STK11	1.37e-05	2	129	2	37573301
Pubmed	The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.	BTN3A2 BTN3A1	1.37e-05	2	129	2	22846996
Pubmed	Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium.	ABCA1 APOB	1.37e-05	2	129	2	30076206
Pubmed	Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.	STAT3 STK11	1.37e-05	2	129	2	28581518
Pubmed	Glucocorticoid receptor regulates ATP-binding cassette transporter-A1 expression and apolipoprotein-mediated cholesterol efflux from macrophages.	ABCA1 NR3C1	1.37e-05	2	129	2	16254209
Pubmed	TLR2 stimulates ABCA1 expression via PKC-η and PLD2 pathway.	ABCA1 TLR2	1.37e-05	2	129	2	23261454
Pubmed	CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.	BTN3A2 BTN3A1	1.37e-05	2	129	2	21113407
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DOCK11 EDC4 ARHGEF16 TRIP11 STAT3 PTK2B IPO9 MDN1 MAST4 KMT2A AKAP11 PLCH1 DCP1A	2.01e-05	861	129	13	36931259
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	ABCA1 APOB NR3C1 ARHGAP35 STAT3 CHUK PAX8 RAI1	3.48e-05	331	129	8	20634891
Pubmed	SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma.	FAM220A STAT3	4.09e-05	3	129	2	23917203
Pubmed	MiR-21 modulates hTERT through a STAT3-dependent manner on glioblastoma cell growth.	TERT STAT3	4.09e-05	3	129	2	22709411
Pubmed	The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells.	STAT3 STK11	4.09e-05	3	129	2	24913037
Pubmed	Proline-rich tyrosine kinase 2 via enhancing signal transducer and activator of transcription 3-dependent cJun expression mediates retinal neovascularization.	STAT3 PTK2B	4.09e-05	3	129	2	27210483
Pubmed	Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206+ macrophagesIL-10 activation.	STAT3 TLR2	4.09e-05	3	129	2	36398889
Pubmed	The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor.	ABCA1 STAT3	4.09e-05	3	129	2	19783654
Pubmed	A human microprotein that interacts with the mRNA decapping complex.	EDC4 DCP1A	4.09e-05	3	129	2	27918561
Pubmed	The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas.	CHUK STK11	4.09e-05	3	129	2	23597566
Pubmed	The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6.	EDC4 DCP1A	4.09e-05	3	129	2	25970328
Pubmed	TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.	CDC25A ESPL1	4.09e-05	3	129	2	33282948
Pubmed	Tristetraprolin-dependent post-transcriptional regulation of inflammatory cytokine mRNA expression by apolipoprotein A-I: role of ATP-binding membrane cassette transporter A1 and signal transducer and activator of transcription 3.	ABCA1 STAT3	4.09e-05	3	129	2	21339300
Pubmed	LGR5 expression is controled by IKKα in basal cell carcinoma through activating STAT3 signaling pathway.	STAT3 CHUK	4.09e-05	3	129	2	27049829
Pubmed	Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs.	STAT3 SGPL1	4.09e-05	3	129	2	25347472
Pubmed	Tumor suppressor LKB1 inhibits activation of signal transducer and activator of transcription 3 (STAT3) by thyroid oncogenic tyrosine kinase rearranged in transformation (RET)/papillary thyroid carcinoma (PTC).	STAT3 STK11	4.09e-05	3	129	2	17761947
Pubmed	Long-term persistent infection of HPV 16 E6 up-regulate SP1 and hTERT by inhibiting LKB1 in lung cancer cells.	TERT STK11	4.09e-05	3	129	2	28813465
Pubmed	PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma.	TERT PAX8	4.09e-05	3	129	2	18632625
Pubmed	Quantitative measurement of telomerase reverse transcriptase, thyroglobulin and thyroid transcription factor 1 mRNAs in anaplastic thyroid carcinoma tissues and cell lines.	TERT TG	4.09e-05	3	129	2	17671725
Pubmed	Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile.	ABCA1 STAT3	4.09e-05	3	129	2	18239666
Pubmed	Recently reported familial hypercholesterolemia-related mutations from cases in the Middle East and North Africa region.	ABCA1 APOB	4.09e-05	3	129	2	30694837
Pubmed	Trypanosoma cruzi, the causative agent of Chagas disease, modulates interleukin-6-induced STAT3 phosphorylation via gp130 cleavage in different host cells.	STAT3 TLR2	4.09e-05	3	129	2	23253440
Pubmed	Growth inhibition of KRAS‑ and EGFR‑mutant lung adenocarcinoma by cosuppression of STAT3 and the SRC/ARHGAP35 axis.	ARHGAP35 STAT3	4.09e-05	3	129	2	30015929
Pubmed	Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers.	CHUK TLR2	4.09e-05	3	129	2	20940109
Pubmed	RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays.	NR3C1 NCOA4	4.09e-05	3	129	2	10517667
Pubmed	ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3.	CAND1 STAT3	4.09e-05	3	129	2	38148115
Pubmed	FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop.	NR3C1 STK11	4.09e-05	3	129	2	22848740
Pubmed	A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties.	NELFA NR3C1	4.09e-05	3	129	2	24097989
Pubmed	Cell migration inducing hyaluronidase 1 (CEMIP) activates STAT3 pathway to facilitate cell proliferation and migration in breast cancer.	STAT3 CEMIP	4.09e-05	3	129	2	32757700
Pubmed	Hypercapnic duty cycle is an intermediate physiological phenotype linked to mouse chromosome 5.	GRK3 NOS1	4.09e-05	3	129	2	12794091
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	RANBP2 NELFA NR3C1 PIAS2 CTTNBP2NL DNTTIP2 STAT3 ZC3H11A DCP1A	4.41e-05	444	129	9	34795231
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	RANBP2 CAND1 EDC4 IARS2 IPO9 DCP1A	5.76e-05	179	129	6	36261009
Pubmed	Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.	PLCH1 PLCE1	8.15e-05	4	129	2	21041529
Pubmed	Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex.	BTN3A2 BTN3A1	8.15e-05	4	129	2	9382921
Pubmed	Phosphorylation of STAT3 mediates the induction of cyclooxygenase-2 by cortisol in the human amnion at parturition.	NR3C1 STAT3	8.15e-05	4	129	2	26508788
Pubmed	Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling.	STAT3 TLR2	8.15e-05	4	129	2	20600022
Pubmed	Serum amyloid A3 exacerbates cancer by enhancing the suppressive capacity of myeloid-derived suppressor cells via TLR2-dependent STAT3 activation.	STAT3 TLR2	8.15e-05	4	129	2	24659444
Pubmed	A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells.	ARHGAP35 PTK2B	8.15e-05	4	129	2	19435801
Pubmed	Effects of familial hypercholesterolemia-associated genes on the phenotype of premature myocardial infarction.	LDLRAP1 APOB	8.15e-05	4	129	2	30971288
Pubmed	A locus on mouse chromosome 2 is involved in susceptibility to congenital hypothyroidism and contains an essential gene expressed in thyroid.	TG PAX8	8.15e-05	4	129	2	20160132
Pubmed	Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation.	RANBP2 PIAS2	8.15e-05	4	129	2	16204249
Pubmed	A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression.	ABCA1 APOB	8.15e-05	4	129	2	21779326
Pubmed	Role of tyrosine phosphorylation in ligand-independent sequestration of CXCR4 in human primary monocytes-macrophages.	PTK2B GRK3	8.15e-05	4	129	2	11668182
Pubmed	Synergistic effects of BTN3A1, SHP2, CD274, and STAT3 gene polymorphisms on the risk of systemic lupus erythematosus: a multifactorial dimensional reduction analysis.	BTN3A1 STAT3	8.15e-05	4	129	2	37688767
Pubmed	Interleukin-27 inhibits foam cell formation by promoting macrophage ABCA1 expression through JAK2/STAT3 pathway.	ABCA1 STAT3	8.15e-05	4	129	2	25194807
Pubmed	VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex.	STK11 VGLL4	8.15e-05	4	129	2	24458094
Pubmed	Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation.	STAT3 PTK2B	8.15e-05	4	129	2	14963038
Pubmed	PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations.	TG PAX8	8.15e-05	4	129	2	15494458
Pubmed	Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus.	SLC17A3 SLC17A1	8.15e-05	4	129	2	12367519
Pubmed	TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation.	TG PAX8	8.15e-05	4	129	2	19010321
Pubmed	Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages.	ABCA1 STAT3	8.15e-05	4	129	2	26989082
Pubmed	TGF-beta-like transcriptional effects of thyroglobulin (Tg) in mouse mesangial cells.	TG PAX8	8.15e-05	4	129	2	17495424
Pubmed	Iodinated TG in Thyroid Follicular Lumen Regulates TTF-1 and PAX8 Expression via TSH/TSHR Signaling Pathway.	TG PAX8	8.15e-05	4	129	2	28322461
Pubmed	Minireview: thyrotropin receptor signaling in development and differentiation of the thyroid gland: insights from mouse models and human diseases.	TG PAX8	8.15e-05	4	129	2	15231702
Pubmed	Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation.	STAT3 CHUK	8.15e-05	4	129	2	16651533
Pubmed	The impact of APOA5, APOB, APOC3 and ABCA1 gene polymorphisms on ischemic stroke: Evidence from a meta-analysis.	ABCA1 APOB	8.15e-05	4	129	2	28865324
Pubmed	Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.	ABCA1 APOB EDC4	8.36e-05	23	129	3	22399527
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	STK36 ARHGAP35 FAT2 IPO9 SGPL1 ARID2 SLITRK5 KDM2A PLCH1	9.80e-05	493	129	9	15368895
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	FRMPD4 LRRK2 APOB ARHGAP35 CTTNBP2NL CHUK AP3B2 CNGB3 USPL1	1.32e-04	513	129	9	25798074
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	EDC4 ARHGAP35 CTTNBP2NL MAST4 AKAP11 DCP1A	1.35e-04	209	129	6	36779422
Pubmed	Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway.	STAT3 SGPL1	1.36e-04	5	129	2	22606352
Pubmed	Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP.	FAM220A STAT3	1.36e-04	5	129	2	26026268
Pubmed	SPATC1L maintains the integrity of the sperm head-tail junction.	AKAP11 SPATC1L	1.36e-04	5	129	2	30026308
Pubmed	Monoubiquitination of RPN10 regulates substrate recruitment to the proteasome.	PSMD4 PSMD8	1.36e-04	5	129	2	20542005
GeneFamily	Butyrophilins\|V-set domain containing\|C2-set domain containing	BTN3A2 BTN3A1 BTN3A3	4.70e-05	15	87	3	458
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FRMPD4 EPB41L4B FRMPD1 PTK2B	9.73e-05	50	87	4	1293
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF2 ECT2L ARHGEF25 ARHGEF16	2.87e-04	66	87	4	722
GeneFamily	Zinc fingers CXXC-type	KMT2A KDM2A	1.46e-03	12	87	2	136
GeneFamily	Laminin subunits	LAMB4 LAMC3	1.46e-03	12	87	2	626
GeneFamily	AT-rich interaction domain containing	KDM5D ARID2	2.31e-03	15	87	2	418
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF2 DOCK11 ARHGEF16 GRK3 AGAP9	3.17e-03	206	87	5	682
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCH1 PLCE1	3.71e-03	19	87	2	832
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPB41L4B ECT2L TG CRYBB3 GRK3 PAX8 BCAM	5.17e-07	164	129	7	cdb8cd2d6b369189ea77e4946738e2816d502e03
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPB41L4B ECT2L TG CRYBB3 GRK3 PAX8 BCAM	5.17e-07	164	129	7	5dbfcdd450f652b16d97da53b528d4584b0eabcf
ToppCell	facs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPB41L4B ECT2L TG CRYBB3 GRK3 PAX8 BCAM	5.17e-07	164	129	7	f1423f4434af4af9c60c8a5b0b0abec4a7df9401
ToppCell	facs-Trachea-nan-18m-Epithelial-mucus_secreting_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPB41L4B ECT2L TG CRYBB3 GRK3 PAX8 BCAM	5.39e-07	165	129	7	7e7643834ed483aec04f513cca38d6367fda9ff8
ToppCell	facs-Thymus-Epithelium-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NKIRAS1 PAPSS2 GOLPH3L ARID2 TLR2 LRRD1	8.29e-07	110	129	6	3a641dced828ed97a8eea70d0a7b76f33630c9be
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 STAB2 FRMPD4 APOB PCDH11X PLCH1 PLCE1	1.12e-06	184	129	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 STAB2 FRMPD4 APOB PCDH11X PLCH1 PLCE1	1.12e-06	184	129	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	STK36 STAB2 FRMPD4 APOB PCDH11X PLCH1 PLCE1	1.12e-06	184	129	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	RA-08._Macrophage\|World / Chamber and Cluster_Paper	IQGAP2 MTSS1 PAPSS2 CTTNBP2NL TG PTK2B TLR2	1.54e-06	193	129	7	5fd22db1825d105709fcc0aa4955c99a117e3c82
ToppCell	RA-08._Macrophage\|RA / Chamber and Cluster_Paper	IQGAP2 DOCK11 MTSS1 PAPSS2 TG PTK2B TLR2	1.59e-06	194	129	7	ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GABRE RBBP8 MTSS1 CEMIP FAT2 LGR6 BCAM	1.89e-06	199	129	7	94a7867e800df352731796de8c24cba133c29622
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4\|Lung / Manually curated celltypes from each tissue	ARMC3 RASGRF2 ECT2L LAMC3 TERT PLCH1	7.84e-06	162	129	6	91cc14aec8d580cf97a1929bc1acb00fcbcdb57a
ToppCell	facs-Marrow-T-cells-3m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ECT2L CFAP20DC EXD2 AKAP11 POLQ FDXACB1	1.03e-05	170	129	6	d70aaa0f4e5034bb9f61b832b5f9123870936d3c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB4 RBBP8 LRRK2 PAPSS2 TLR2 NOS1	1.62e-05	184	129	6	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	facs-Trachea-nan-24m-Epithelial-mucus_secreting_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF16 TG PLPP2 PAX8 BCAM LRRD1	1.67e-05	185	129	6	e502ec54971f518d0cf1b619b745607a8ab5ddf3
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IQGAP2 RASGRF2 DOCK11 FRMPD1 PLCH1 PLCE1	1.94e-05	190	129	6	8c9c230a509afaeee50644153974a5642b01a2b8
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IQGAP2 RASGRF2 DOCK11 FRMPD1 CEMIP PLCE1	1.94e-05	190	129	6	e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	CDK10 IPO9 MDN1 KMT2A ESPL1 ZNF292	2.06e-05	192	129	6	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	wk_08-11-Hematologic-Meg-ery-Definitive_erythroblast\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ANKLE1 KDM5D NCOA4 PTK2B STK11 ASB7	2.12e-05	193	129	6	be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCell	COPD-Myeloid-Macrophage\|World / Disease state, Lineage and Cell class	ABCA1 LRRK2 PAPSS2 CTTNBP2NL PTK2B TLR2	2.18e-05	194	129	6	7d682408e9a6239a4e47befc9376e760cc3d133a
ToppCell	LA-08._Macrophage\|World / Chamber and Cluster_Paper	IQGAP2 DOCK11 MTSS1 PAPSS2 PTK2B TLR2	2.18e-05	194	129	6	c1805572bcc11b1cd29083329d7b5911489fb758
ToppCell	COVID_non-vent-Lymphocytic-T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	LDLRAP1 RASGRF2 BTN3A2 BTN3A1 MAST4 KMT2A	2.24e-05	195	129	6	4bdedd924564a260841a9153604026b57487c83d
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	ABCA1 MTSS1 LRRK2 PAPSS2 CTTNBP2NL GRK3	2.24e-05	195	129	6	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 KDM5D PAPSS2 TRIP11 GRK3 KMT2A	2.24e-05	195	129	6	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	COVID-19-Myeloid-Transitioning_MDM\|COVID-19 / group, cell type (main and fine annotations)	ABCA1 IQGAP2 PTK2B GRK3 SGPL1 TLR2	2.31e-05	196	129	6	4929cfed1f150c1fde4d79cb49895c2ea467a18f
ToppCell	distal-3-Epithelial-Basal\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HTR1F ARHGEF16 FAT2 PLPP2 SLITRK5 BCAM	2.38e-05	197	129	6	72ac9068cfd8f04c521a858d55eb8b5764de0282
ToppCell	cellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARHGEF16 CEMIP FAT2 PLPP2 LGR6 BCAM	2.44e-05	198	129	6	7063d74d79f53d5c59c853a2575f9d3ef12f19ea
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	STK17A ARHGEF16 CEMIP FAT2 LGR6 BCAM	2.44e-05	198	129	6	fc00cb25cdc6c31b7f9d397bc9f9a8f4e9708003
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	RBBP8 MTSS1 CEMIP FAT2 LGR6 BCAM	2.44e-05	198	129	6	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	distal-Epithelial-Basal-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	HTR1F ARHGEF16 FAT2 PLPP2 SLITRK5 BCAM	2.44e-05	198	129	6	dda0bf3a48f738df590ce23b891d82be19e10d66
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Basal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF16 TG FAT2 PLPP2 SLITRK5 BCAM	2.51e-05	199	129	6	e9c47f565a0a7737ecff68569d668aeb707ae5a6
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_3-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	STK17A ARHGEF16 FAT2 PLPP2 LGR6 BCAM	2.59e-05	200	129	6	41705bbba40eb5ddca0b223191aac1bce00163b8
ToppCell	Parenchyma_COVID-19-Epithelial-TX-Basal_3\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	STK17A ARHGEF16 FAT2 PLPP2 LGR6 BCAM	2.59e-05	200	129	6	53e04399d0308b40ae99fbfaa4ff62bf061822d8
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	LDLRAP1 RASGRF2 BTN3A2 ZC3H11A MDN1 MAST4	2.59e-05	200	129	6	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_basal-Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RBBP8 ARHGEF16 CEMIP FAT2 LGR6 BCAM	2.59e-05	200	129	6	9da214f756a03516eaafde00289b90f69623b9f3
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_3\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	STK17A ARHGEF16 FAT2 PLPP2 LGR6 BCAM	2.59e-05	200	129	6	cc8df398532c9324fd3e171000b1ea5c208cd691
ToppCell	Biopsy_Other_PF-Epithelial-Basal\|Biopsy_Other_PF / Sample group, Lineage and Cell type	ARHGEF16 CEMIP FAT2 PLPP2 LGR6 BCAM	2.59e-05	200	129	6	7098ae4b0ea8ba607519eaed8577c577530fc2a1
ToppCell	Bronchial-10x5prime-Epithelial-Epi_airway_basal-Basal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF16 CEMIP FAT2 PLPP2 LGR6 BCAM	2.59e-05	200	129	6	0594ca7bc313b73e1dc800cf058f8f798b0284cb
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a6.Nell1_(Neuron.Slc17a6.Nell1)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CPN2 ARHGEF16 FAT2 LGR6	4.83e-05	69	129	4	11e6747ed4a45acee210c48ba670bfe0375fb19b
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a6.Nell1_(Neuron.Slc17a6.Nell1)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CPN2 ARHGEF16 FAT2 LGR6	4.83e-05	69	129	4	96564b46008a6e5220b6596cbbe0a24e9b5955ee
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DOCK11 EDC4 CHUK IPO9 SLC22A16	6.06e-05	143	129	5	8f897278f9ccc82ae35e4f30c5f930b2a3eb509d
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IQGAP2 LAMC3 PAPSS2 CREB3L1 TG	9.43e-05	157	129	5	1e3a4a7193d95f09d71c2dfe704b8e626c6d9624
ToppCell	LV-11._Adipocyte\|World / Chamber and Cluster_Paper	GABRE TRARG1 DOCK11 GRK3 LRRC8B	1.23e-04	166	129	5	7e5852891714465c6228c9f955fd511ec79d0e02
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	INTS6L ZC3H11A MDN1 GRK3 HPF1	1.26e-04	167	129	5	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	HTR1F SVOPL TG SLC22A16 ESPL1	1.26e-04	167	129	5	315cde87eed2b42a1b9b068fae94caa10ec64c70
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB4 FRMPD4 FAT2 LGR6 BCAM	1.37e-04	170	129	5	0cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LAMB4 FRMPD4 FAT2 LGR6 BCAM	1.37e-04	170	129	5	2d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_dendritic-CD1c-positive_myeloid_dendritic_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	ABCA1 MTSS1 PAPSS2 CTTNBP2NL TLR2	1.37e-04	170	129	5	cc66ac6846c58be9493eb270644ee3ce0f86cfea
ToppCell	343B-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HTR1F SVOPL TG SLC22A16 ESPL1	1.41e-04	171	129	5	4ccd88cf812dd8bfdc55159c6f504e9c84e4f4fc
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial-endothelial_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 ARMC3 RASGRF2 TRARG1 SPATC1L	1.49e-04	173	129	5	a2c1ef3f4d7e9f68fc77ee7c42a4727bdea5da94
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 ARMC3 RASGRF2 TRARG1 SPATC1L	1.49e-04	173	129	5	4830136f1f1976e00ac9af9062a531ac42533041
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 ARMC3 RASGRF2 TRARG1 SPATC1L	1.49e-04	173	129	5	0b79e2a4fd19d524c24b69a6b524ffc6affdabe5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARMC3 DOCK11 EML6 LRRK2 PAX8	1.57e-04	175	129	5	284fdc7a9d303636a637041846850d19d114861a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRE HTR1F PCDH11X BCAM PLCH1	1.57e-04	175	129	5	d4827b4dfad07f11cbdd47fbed287af1afb9b1b8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 MTSS1 EML6 LRRK2 PAX8	1.61e-04	176	129	5	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK11 PLCH1 ESPL1 NOS1 PLCE1	1.65e-04	177	129	5	2b675840b7d2bb536c2c600936733bd9e97e7120
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HTR1F STK17A SVOPL SLITRK5 BCAM	1.65e-04	177	129	5	8c6d8a1c469346e66f9095d86b4615f8fc611362
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	BTN3A2 BTN3A1 BTN3A3 ZC3H11A LGR6	1.65e-04	177	129	5	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	BTN3A2 BTN3A1 BTN3A3 ZC3H11A LGR6	1.65e-04	177	129	5	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	BTN3A2 BTN3A1 BTN3A3 ZC3H11A LGR6	1.65e-04	177	129	5	d5aeda113afaa2425874394610344570c9078478
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 EML6 LRRK2 PAX8 BCAM	1.70e-04	178	129	5	c20f050344a2e120e685e2a7fe36c6dfc1dc37b6
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCA1 PAPSS2 MAST4 CNGB3 AKAP11	1.70e-04	178	129	5	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____fenestrated_capillary_endothelial\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 TRARG1 LAMC3 CRYBB3 LRRD1	1.79e-04	180	129	5	79c5725f02e038d0187f4a1e1591f2492538aa57
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KDM5D BTN3A1 BTN3A3 KMT2A LGR6	1.83e-04	181	129	5	986c036e656f24fe374807e2711cec9e3c83c892
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	IQGAP2 RBBP8 PIAS2 CREB3L1 PLCH1	1.83e-04	181	129	5	8fcc9e77fee7c248df26b6c59b10e672242e2084
ToppCell	droplet-Lung-LUNG-30m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTSS1 NCOA4 SGPL1 TLR2 PNPLA7	1.83e-04	181	129	5	8fcdab61fad2efd324d2b27c58f5a594f1dc15de
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK11 FRMPD1 PLCH1 NOS1 PLCE1	1.88e-04	182	129	5	08aff7112c9dac0ef5540300516a604782b21169
ToppCell	facs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EPB41L4B SVOPL CEMIP LGR6 ESPL1	1.88e-04	182	129	5	a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MTSS1 NCOA4 SGPL1 TLR2 PNPLA7	1.88e-04	182	129	5	be48ce85991bceeff938ba080e6bf9cc62176b05
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK11 FRMPD1 PLCH1 NOS1 PLCE1	1.88e-04	182	129	5	a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HTR1F FRMPD4 STK17A SLITRK5 BCAM	1.93e-04	183	129	5	ec2af3402b51f11466d2a5783a6b33746b6a7fc9
ToppCell	COVID-19-kidney-PCT-S1\|kidney / Disease (COVID-19 only), tissue and cell type	DOCK11 LRRK2 MAST4 SLC17A1 PAX8	1.98e-04	184	129	5	51ed1ebfdef45149541917c66cbacad87072e51f
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGEF16 TG PLPP2 PAX8 BCAM	1.98e-04	184	129	5	61caaa31975e05c9a6512079c791fed5a9e2d39f
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGEF16 TG PLPP2 PAX8 BCAM	1.98e-04	184	129	5	03da0f0f89f1ca5a3ccca1e22972f3129464e68e
ToppCell	facs-Trachea-24m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGEF16 TG PLPP2 PAX8 BCAM	1.98e-04	184	129	5	9ed2a65a4ca0ebbbb89ace61027522f93369843d
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	ABCA1 HTR1F DOCK11 NR3C1 STAT3	1.98e-04	184	129	5	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 EML6 LRRK2 PAX8 BCAM	1.98e-04	184	129	5	da06ff24ee2b2cf4715fdfce43030b2da9e0aaf8
ToppCell	COVID-19-Endothelial_cells-Arterial_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	SLC17A3 RASGRF2 CTTNBP2NL MAST4 NOS1	1.98e-04	184	129	5	0f19494789f38ab1a420545e15e748ca7eb345c3
ToppCell	droplet-Lung-18m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l33-52\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	EML6 ANKLE1 CDC25A POLQ ESPL1	2.03e-04	185	129	5	47c69500877b851c0c9744f5e1ef2ee0bff99168
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	IQGAP2 EML6 PAPSS2 PAX8 PCDH11X	2.03e-04	185	129	5	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB4 LRRK2 PAPSS2 PLPP2 NOS1	2.03e-04	185	129	5	74b787e225d83efcb84e79c23499febe1a106622
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L4_RORB_CCDC168\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HTR1F LRRK2 PAPSS2 CEMIP PLCH1	2.03e-04	185	129	5	5a0340c25196453f19e424d346efbf66d2c53ac3
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DOCK11 FRMPD1 PLCH1 NOS1 PLCE1	2.03e-04	185	129	5	f4ac62009c0ad3346e71b809e17727303c4df153
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARMC3 DOCK11 EML6 LRRK2 PAX8	2.08e-04	186	129	5	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IQGAP2 RASGRF2 DOCK11 PLCH1 PLCE1	2.08e-04	186	129	5	6379609b7ace80683f5754b16aa77f11b43766ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC17A3 DOCK11 LRRK2 SLC17A1 PAX8	2.13e-04	187	129	5	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ABCA1 IQGAP2 RASGRF2 MTSS1 AGAP9	2.13e-04	187	129	5	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	Control-Endothelial_cells-Arterial_endothelial_cells\|Control / group, cell type (main and fine annotations)	SLC17A3 RASGRF2 PAPSS2 CTTNBP2NL NOS1	2.13e-04	187	129	5	81affaab3fe3e1daea45ada6445e906ddd33950e
ToppCell	COVID-19-lung-Artery_EC\|lung / Disease (COVID-19 only), tissue and cell type	SLC17A3 RASGRF2 CTTNBP2NL MAST4 NOS1	2.19e-04	188	129	5	eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCell	Control-Myeloid-Monocytes\|Control / group, cell type (main and fine annotations)	MTSS1 TG PTK2B GRK3 TLR2	2.24e-04	189	129	5	3335d16bd0ffa0c1ddd06d7da645299148130c3f
ToppCell	facs-Trachea-3m-Epithelial\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ARHGEF16 TG FAT2 PAX8 BCAM	2.24e-04	189	129	5	f8959cc2c14899c8dfeb1b5e51e187537df2f03e
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NCOA4 CTTNBP2NL SGPL1 TLR2 PNPLA7	2.24e-04	189	129	5	b2542b6fcf7bc10d29158d42b03182a939ff135a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMB4 LRRK2 PAPSS2 TLR2 NOS1	2.24e-04	189	129	5	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IQGAP2 RASGRF2 DOCK11 FRMPD1 CEMIP	2.24e-04	189	129	5	99a13b1b669b0cd36e3096632351d9ade25d1173
ToppCell	COVID-19-Heart-Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	IQGAP2 DOCK11 MTSS1 GRK3 TLR2	2.24e-04	189	129	5	2586f4088721c5debec86c2b211b739fd33713eb
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RASGRF2 DOCK11 PLCH1 NOS1 PLCE1	2.30e-04	190	129	5	d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RASGRF2 DOCK11 FRMPD1 PLCH1 PLCE1	2.30e-04	190	129	5	305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRK2 PAPSS2 CEMIP PTK2B MAST4	2.30e-04	190	129	5	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	LV-08._Macrophage\|World / Chamber and Cluster_Paper	IQGAP2 DOCK11 MTSS1 PTK2B TLR2	2.35e-04	191	129	5	e7a0bc46ba9ba772636a583f3387748418e18832
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	RANBP2 KDM2A AGAP9 USPL1 ZNF292	2.35e-04	191	129	5	1ecd9849d14d5ebf3daf610e83fb50820cafd3ed
Drug	h CBDCA	STK36 ABCA1 PSMD4 TERT MAP3K12	1.81e-06	37	126	5	CID000002568
Drug	2,4-di-tert-butylphenol	APOB ARHGEF16 CREB3L1	3.27e-06	6	126	3	CID000007311
Drug	SU11274	STAT3 PTK2B STK11 PAX8	1.42e-05	27	126	4	CID009549297
Drug	Delsoline [509-18-2]; Down 200; 8.6uM; PC3; HT_HG-U133A	STK17A PAPSS2 BTN3A1 IPO9 MAST4 SLITRK5 LRRC8B PLCE1	1.48e-05	198	126	8	5858_DN
Drug	Hexylcaine hydrochloride [532-76-3]; Up 200; 13.4uM; HL60; HT_HG-U133A	LAMB4 MTSS1 APOB ARHGAP35 PAPSS2 CREB3L1 STK11 PLCE1	1.48e-05	198	126	8	2708_UP
Drug	Butirosin disulfate salt [51022-98-1]; Up 200; 5.4uM; MCF7; HT_HG-U133A	LAMB4 HTR1F CPN2 NR3C1 BTN3A3 PAX8 TLR2 BCAM	1.54e-05	199	126	8	6080_UP
Drug	Edrophonium chloride [116-38-1]; Down 200; 19.8uM; PC3; HT_HG-U133A	LAMC3 ARHGAP35 ARHGEF16 MAST4 TLR2 CNGB3 CDC25A POLQ	1.54e-05	199	126	8	6655_DN
Disease	X-07765 measurement	SLC17A3 SLC17A1	1.87e-05	2	128	2	EFO_0021204
Disease	4-allylphenol sulfate measurement	SLC17A3 SLC17A1	1.87e-05	2	128	2	EFO_0800958
Disease	X-17690 measurement	SLC17A3 SLC17A1	1.87e-05	2	128	2	EFO_0800788
Disease	X-12822 measurement	SLC17A3 SLC17A1	1.87e-05	2	128	2	EFO_0800730
Disease	X-21364 measurement	SLC17A3 SLC17A1	5.59e-05	3	128	2	EFO_0800811
Disease	X-12839 measurement	SLC17A3 SLC17A1	5.59e-05	3	128	2	EFO_0800731
Disease	Hypercholesterolemia, Familial	LDLRAP1 ABCA1 APOB	6.20e-05	18	128	3	C0020445
Disease	cholesterol to total lipids in large LDL percentage	ABCA1 APOB BTN3A2 BCAM	1.04e-04	56	128	4	EFO_0022235
Disease	X-23787 measurement	SLC17A3 SLC17A1	1.11e-04	4	128	2	EFO_0800866
Disease	transient cerebral ischemia (implicated_via_orthology)	TERT STAT3 KMT2A NOS1	1.75e-04	64	128	4	DOID:224 (implicated_via_orthology)
Disease	Alzheimer disease, high density lipoprotein cholesterol measurement	ABCA1 APOB BCAM	1.93e-04	26	128	3	EFO_0004612, MONDO_0004975
Disease	X-21829 measurement	SLC17A3 SLC17A1	2.77e-04	6	128	2	EFO_0800830
Disease	X-13866 measurement	SLC17A3 SLC17A1	2.77e-04	6	128	2	EFO_0800745
Disease	cervical cancer	TERT STAT3 STK11	4.32e-04	34	128	3	C4048328
Disease	Familial melanoma	TERT STK11	5.14e-04	8	128	2	cv:C1512419
Disease	Malignant melanoma of skin	TERT STK11	5.14e-04	8	128	2	cv:C0151779
Disease	Familial hypercholesterolemia	LDLRAP1 APOB	5.14e-04	8	128	2	cv:C0020445
Disease	Melanoma	TERT STK11	5.14e-04	8	128	2	cv:C0025202
Disease	Lymphoid leukemia	TERT KMT2A	5.14e-04	8	128	2	C0023448
Disease	Hypercholesterolemia	LDLRAP1 ABCA1 APOB	6.50e-04	39	128	3	C0020443
Disease	4-androsten-3beta,17beta-diol disulfate 2 measurement	SLC17A3 SLC17A1	6.59e-04	9	128	2	EFO_0021114
Disease	familial melanoma (is_implicated_in)	TERT STK11	6.59e-04	9	128	2	DOID:6846 (is_implicated_in)
Disease	Melancholia	NR3C1 TG NOS1	7.53e-04	41	128	3	C0025193
Disease	Depression, Neurotic	NR3C1 TG NOS1	7.53e-04	41	128	3	C0282126
Disease	Depressive Syndrome	NR3C1 TG NOS1	8.09e-04	42	128	3	C0086133
Disease	triple-negative breast cancer	ANKLE1 TERT	8.21e-04	10	128	2	EFO_0005537
Disease	decadienedioic acid (C10:2-DC) measurement	SLC17A3 SLC17A1	8.21e-04	10	128	2	EFO_0800598
Disease	serum metabolite measurement	LAMB4 SLC17A3 PKD1L1 LAMC3 APOB PAPSS2 CDK10 STAT3 CFAP20DC MROH1 SLC22A16 SLC17A1	8.60e-04	945	128	12	EFO_0005653
Disease	Pancreatic Neoplasm	RBBP8 TERT STAT3 STK11	9.60e-04	100	128	4	C0030297
Disease	Colorectal Carcinoma	ABCA1 RASGRF2 APOB STK11 PAX8 TLR2 PCDH11X KDM2A LGR6 ZNF292	9.98e-04	702	128	10	C0009402
Disease	Osteogenesis imperfecta type III (disorder)	WNT1 CREB3L1	1.00e-03	11	128	2	C0268362
Disease	beta thalassemia (is_marker_for)	APOB TERT	1.00e-03	11	128	2	DOID:12241 (is_marker_for)
Disease	androstenediol (3beta,17beta) monosulfate (2) measurement	SLC17A3 SLC17A1	1.00e-03	11	128	2	EFO_0800295
Disease	Malignant neoplasm of pancreas	RBBP8 TERT STAT3 STK11	1.03e-03	102	128	4	C0346647
Disease	Endogenous depression	NR3C1 TG NOS1	1.06e-03	46	128	3	C0011573
Disease	phenylacetylglutamine measurement	RBBP8 LRRC8B	1.20e-03	12	128	2	EFO_0021013
Disease	level of Ceramide (d42:2) in blood serum	APOB SGPL1	1.20e-03	12	128	2	OBA_2045186
Disease	Neurobehavioral Manifestations	NOS1 RAI1	1.20e-03	12	128	2	C0525041
Disease	Colorectal Neoplasms	ABCA1 PAX8 TLR2 KDM2A LGR6 ZNF292	1.35e-03	277	128	6	C0009404
Disease	Benign tumor of pancreas	RBBP8 STK11	1.41e-03	13	128	2	C0347284
Disease	methylcobalamin deficiency type cblE, response to antineoplastic agent	KMT2A LRRC8B	1.41e-03	13	128	2	GO_0097327, MONDO_0009354
Disease	Congenital Hypothyroidism	TG PAX8	1.41e-03	13	128	2	C0010308
Disease	Hyperlipoproteinemia Type IIb	ABCA1 APOB	1.41e-03	13	128	2	C1704417
Disease	free cholesterol in large LDL measurement	ABCA1 APOB BCAM	1.43e-03	51	128	3	EFO_0022176
Disease	response to tenofovir	SLC17A3 SLC17A1 CDC25A	1.43e-03	51	128	3	EFO_0009279
Disease	free cholesterol to total lipids in small HDL percentage	ABCA1 APOB BCAM	1.43e-03	51	128	3	EFO_0022285
Disease	total lipids in LDL measurement	ABCA1 APOB BCAM	1.51e-03	52	128	3	EFO_0022308
Disease	peripheral arterial disease, traffic air pollution measurement	ABCA1 EPB41L4B MTSS1 VIT PLPP2	1.61e-03	194	128	5	EFO_0004265, EFO_0007908
Disease	congenital hypothyroidism (implicated_via_orthology)	TG PAX8	1.64e-03	14	128	2	DOID:0050328 (implicated_via_orthology)
Disease	Carcinoma, Granular Cell	STAT3 STK11 KMT2A PLCE1	1.66e-03	116	128	4	C0205644
Disease	Adenocarcinoma, Tubular	STAT3 STK11 KMT2A PLCE1	1.66e-03	116	128	4	C0205645
Disease	Adenocarcinoma, Oxyphilic	STAT3 STK11 KMT2A PLCE1	1.66e-03	116	128	4	C0205642
Disease	Carcinoma, Cribriform	STAT3 STK11 KMT2A PLCE1	1.66e-03	116	128	4	C0205643
Disease	Adenocarcinoma, Basal Cell	STAT3 STK11 KMT2A PLCE1	1.66e-03	116	128	4	C0205641
Disease	Adenocarcinoma	STAT3 STK11 KMT2A PLCE1	1.66e-03	116	128	4	C0001418
Disease	prostate cancer (is_implicated_in)	STAT3 CHUK TLR2 CDC25A	1.72e-03	117	128	4	DOID:10283 (is_implicated_in)
Disease	phospholipids in medium HDL measurement	ABCA1 MYO1H APOB	1.77e-03	55	128	3	EFO_0022295
Disease	metabolic syndrome	ABCA1 APOB EDC4 KMT2A BCAM	1.84e-03	200	128	5	EFO_0000195
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	APOB BTN3A2 GOLPH3L BCAM	1.94e-03	121	128	4	EFO_0008595, EFO_0020943
Disease	total lipids in large LDL	ABCA1 APOB BCAM	1.97e-03	57	128	3	EFO_0022163
Disease	cholesterol in large LDL measurement	ABCA1 APOB BCAM	1.97e-03	57	128	3	EFO_0021901
Disease	total lipids in medium HDL measurement	ABCA1 MYO1H APOB	2.07e-03	58	128	3	EFO_0022310
Disease	free cholesterol in medium HDL measurement	ABCA1 MYO1H APOB	2.07e-03	58	128	3	EFO_0022267
Disease	Hyperlipoproteinemia Type IIa	ABCA1 APOB	2.15e-03	16	128	2	C0745103
Disease	colorectal mucinous adenocarcinoma	RASGRF2 SLC22A16	2.15e-03	16	128	2	EFO_0009361
Disease	X-21410 measurement	SLC17A3 SLC17A1	2.15e-03	16	128	2	EFO_0800813
Disease	amygdala volume change measurement	PKD1L1 SPATA31C1	2.15e-03	16	128	2	EFO_0021490
Disease	triglycerides to total lipids in small LDL percentage	APOB BTN3A2 BCAM	2.17e-03	59	128	3	EFO_0022337
Disease	free cholesterol in HDL measurement	ABCA1 MYO1H APOB	2.39e-03	61	128	3	EFO_0022264
Disease	phospholipids in HDL measurement	ABCA1 MYO1H APOB	2.39e-03	61	128	3	EFO_0022293
Disease	choline measurement	ABCA1 MYO1H APOB PLCH1	2.52e-03	130	128	4	EFO_0010116
Disease	total lipids in HDL measurement	ABCA1 MYO1H APOB	2.62e-03	63	128	3	EFO_0022307
Disease	sinusitis (is_marker_for)	NR3C1 TLR2	2.73e-03	18	128	2	DOID:0050127 (is_marker_for)
Disease	serum hepcidin measurement	EML6 AKAP11	2.73e-03	18	128	2	EFO_0004504
Disease	Pancreatic carcinoma	RBBP8 STK11	3.04e-03	19	128	2	C0235974
Disease	Usual Interstitial Pneumonia	TERT STAT3	3.04e-03	19	128	2	C4721509
Disease	Hamman-Rich Disease	TERT STAT3	3.04e-03	19	128	2	C4721508
Disease	mitochondrial DNA measurement	ANKLE1 TERT CDK10 PTK2B STK11 RAI1	3.15e-03	328	128	6	EFO_0006312
Disease	lipid measurement, high density lipoprotein cholesterol measurement	ABCA1 SLC17A3 MYO1H APOB BCAM RAI1	3.24e-03	330	128	6	EFO_0004529, EFO_0004612
Disease	Familial Idiopathic Pulmonary Fibrosis	TERT STAT3	3.37e-03	20	128	2	C4721952
Disease	estrogen-receptor negative breast cancer	ANKLE1 TERT LGR6	3.68e-03	71	128	3	EFO_1000650
Disease	Osteogenesis imperfecta	WNT1 CREB3L1	3.71e-03	21	128	2	cv:C0029434
Disease	Idiopathic Pulmonary Fibrosis	TERT STAT3	3.71e-03	21	128	2	C1800706
Disease	phospholipids in large HDL measurement	ABCA1 MYO1H APOB	3.97e-03	73	128	3	EFO_0022190
Disease	depressive disorder (implicated_via_orthology)	NR3C1 NOS1	4.07e-03	22	128	2	DOID:1596 (implicated_via_orthology)
Disease	lung disease (is_implicated_in)	NR3C1 TLR2	4.07e-03	22	128	2	DOID:850 (is_implicated_in)
Disease	total lipids in large HDL	ABCA1 MYO1H APOB	4.13e-03	74	128	3	EFO_0022189

Protein segments in the cluster

Peptide	Gene	Start	Entry
RSLLISTKDGLSPQE	TDRD5	16	Q8NAT2
LSKPELLTLFSILEG	CTTNBP2NL	6	Q9P2B4
TFSPELKSLLEGLLQ	GRK3	416	P35626
TSGPLLLTEEEKRTL	CREB3L1	256	Q96BA8
LSLSKNQLTTLPEGI	CPN2	366	P22792
IKSLLSQLESLDLPG	CCDC116	276	Q8IYX3
VTLLSNSKPLGSEAI	AGAP9	136	Q5VTM2
LTLLTTLLEGPGDKT	ARHGEF25	121	Q86VW2
LPVSTVSDLELLKGL	ANKLE1	356	Q8NAG6
LSDKGTTPLQLAIIR	ASB7	146	Q9H672
LLGLEKTASISIADP	BTN3A3	226	O00478
IKSGLDLNTSLSPSL	RBBP8	336	Q99708
LLGLEKTASISIADP	BTN3A1	226	O00481
PSKILVSLTLSGLAL	HTR1F	21	P30939
LKSTSDGLQITLGLL	FAM220A	231	Q7Z4H9
PEDTGTLELLNALTK	ABCA1	1396	O95477
IVLSTESPAALKLGT	ARHGEF16	71	Q5VV41
QPASGESSLIKQLLL	ARID2	1051	Q68CP9
EELTASLVGLPKSLT	AKAP11	1471	Q9UKA4
LTSLETLPKRSNISG	ECT2L	246	Q008S8
TTLLELGAVEPLTKL	ARMC3	61	Q5W041
GTSLPSVDLLQKLRL	DCP1A	386	Q9NPI6
LLVKSGTLLPSDRDS	CEMIP	631	Q8WUJ3
LEGLTLTDSTLVPSL	AP3B2	836	Q13367
KLPENLLSDLSLQSL	RAI1	421	Q7Z5J4
SNSESLLGLLTSDKP	RANBP2	1061	P49792
KTLPLENASILSEGS	RBM18	6	Q96H35
LLNSTLDDGKATLTP	PAX8	266	Q06710
EELTLSPKLQLDGSL	EDC4	651	Q6P2E9
EPSILITITDGNKLT	INTS6L	121	Q5JSJ4
EKPSDSLSASLGLQL	HPF1	66	Q9NWY4
PSLKSLVATGNLLDL	LDLRAP1	201	Q5SW96
AETLPSLSITKLDLQ	PAPSS2	241	O95340
KIATILGSLPSSALI	SLC17A3	291	O00476
PLLKLSCSDTLINEL	OR1S1	196	Q8NH92
LLALETQGSSSPVLK	KIAA0100	391	Q14667
ISLDLTGNLISSLPK	LRRD1	306	A4D1F6
TGNLISSLPKEIREL	LRRD1	311	A4D1F6
LSSPISKFLNGLEIL	MDN1	3766	Q9NU22
ILKSFPDTGSLNLEL	NELFA	96	Q9H3P2
FPDLKGTTSLEILTL	LGR6	321	Q9HBX8
KLDLTDNQLTTLPLA	LGR6	426	Q9HBX8
LKESQILSLLSDIGS	CHUK	116	O15111
SLAPAGQSLTKIETL	MESP2	111	Q0VG99
TLIEPFTLLASKLSQ	NKIRAS1	156	Q9NYS0
SDLELLSSLLPQLTG	KDM5D	1356	Q9BY66
LTTVKALTLIAGSPL	CAND1	626	Q86VP6
KTLPRTLLDILADGT	EXD2	146	Q9NVH0
IGSKVLQLILSDPDS	FAT2	3441	Q9NYQ8
LPSSSEQVILDLKGS	MTSS1	236	O43312
KESSPKLVELLLNSG	LRRK2	751	Q5S007
LLSSVPKDGLKSQEL	NR3C1	671	P04150
GKLPEASRILNTILS	GABRE	66	P78334
PQLTLRATIEKLGSA	FOXJ2	16	Q9P0K8
DLNLSLIPNKSLTTA	PCDH11X	46	Q9BZA7
LERKPSLSLTLTLGE	PLPP2	261	O43688
LSSLLPVLGVAKQDT	MROH1	166	Q8NDA8
LLQSLGLKSTLITDG	MVP	821	Q14764
AIGPTLLLTSDNIKR	PNPLA7	756	Q6ZV29
VTDLLPSLQKLSLDN	LRRC8B	556	Q6P9F7
LTTLTPDTGRILSKL	PIPSL	546	A2A3N6
LKEIEPVLSLLTSGS	NOS1	206	P29475
GSLTLKPEDSTVLLF	NCOA4	126	Q13772
GRTLADLTLLDSPIK	APOB	2011	P04114
VGNTLLLTRLEKDSP	ESPL1	1721	Q14674
LSGIIKRQPVSLDLS	KDM2A	946	Q9Y2K7
EPKLTGLSEISLRLV	DOCK11	1786	Q5JSL3
KDGIPISSLREITLL	CDK10	76	Q15131
ALGLLAPLRETKSTN	FRMPD1	901	Q5SYB0
AQRSLLTLSGPETLK	FRMPD4	626	Q14CM0
PTSAGKTLVAELLIL	POLQ	116	O75417
PSLTDSLLEKVGSIQ	CRYBB3	46	P26998
VLLKSDSPTGDVLLD	GOLPH3L	106	Q9H4A5
STSTLDLGKLQSLPE	COQ4	106	Q9Y3A0
LISVLKNLPESLSNG	MTFMT	216	Q96DP5
LLGLEKTASISIADP	BTN3A2	226	P78410
TESLLPKLDAALSGV	MAP3K12	511	Q12852
DIALLSGPQASKTEL	MAST4	1806	O15021
LKEALVDTLTGILSP	IPO9	21	Q96P70
SLAPSLLDRNKTGLL	TMEM167A	26	Q8TBQ9
RIKTPSGLLINSELE	KMT2A	311	Q03164
DLLTILDTLTSKGNL	LAMB4	1341	A4D0S4
LSTSSKGLLLEDNPS	EML6	946	Q6ZMW3
TLRKLIGSVDDLLPS	PTK2B	916	Q14289
KGILDSLLTQTLPES	FDXACB1	416	Q9BRP7
LSEGKVLSLPLNSSA	BCAM	366	P50895
LTTLTPDTGRILSKL	PSMD4	61	P55036
SLSLTLENKEGPLRS	EPB41L4B	521	Q9H329
LSDSLQLPLLEKTSN	PKD1L1	2806	Q8TDX9
LSLASSPKGTIENIL	CDC25A	316	P30304
PRTLEGLSDLSTIKS	PIAS2	66	O75928
IDLVLSTSTIPKLLG	OR52M1	71	Q8NGK5
IIGALRTSKLLSDPN	TMEM43	91	Q9BTV4
QLVPFSTKSGDTLLL	TMEM43	271	Q9BTV4
LPSSSAGISKELIDL	PLCE1	511	Q9P212
SLTSPLNSKIGALDL	RASGRF2	746	O14827
KLSELLSLDLQGPVS	SLC22A16	321	Q86VW1
DKVLNSIISSLDLLP	IQGAP2	1056	Q13576
LIASTLTGLILKQDP	SLC17A1	411	Q14916
KLASLIDGSSPVSIL	IARS2	281	Q9NSE4
NLLLTTGGTLKISDL	STK11	181	Q15831
EKVSSLSLIQLAGPS	SPATA31C1	681	P0DKV0
LPLTLILVNKRGDTS	ARHGAP35	696	Q9NRY4
LLSPLQDSLVDKTLL	SPATC1L	136	Q9H0A9
SEKLSLLSLGNQSLP	STK36	1276	Q9NRP7
NILLTSESPLGDIKI	STK17A	191	Q9UEE5
TEPVTILSLRKLSLG	SVOPL	6	Q8N434
ILSLRKLSLGTAEPQ	SVOPL	11	Q8N434
RALGPKLLSSSNELV	ROBO4	696	Q8WZ75
LPSQGLSSSAVLEKL	SGPL1	116	O95470
PSELTQLTLESLLGK	CFAP20DC	421	Q6ZVT6
SDLLKTLPTTVQLAL	CNGB3	496	Q9NQW8
SLGLEQPLALTKNSL	VGLL4	126	Q14135
LLKLTSSSIDPGLSI	DNTTIP2	556	Q5QJE6
RSSTSEGLLLKIDPL	MRPL1	296	Q9BYD6
LGSKSLNNLISPDLE	USPL1	81	Q5W0Q7
TSLPVSGVLDQLKSL	SLITRK5	541	O94991
SIEQLTTLAEKLLGP	STAT3	521	P40763
LSTKQGEEPLVRLSL	ZC3H11A	266	O75152
LTKTVLPLNIDSGSD	ZNF292	1246	O60281
DTRLSGLEAPSLQKL	TLE7	391	A0A1W2PR48
SLGLVPKEELSTQSL	VIT	266	Q6UXI7
LGSKLLITASQDPLQ	STAB2	2401	Q8WWQ8
NLLGALSLPVSETAK	PLCH1	976	Q4KWH8
LGKLDIISPQLSSAS	TRIP11	1306	Q15643
LLTDSKSLQLVLEPS	WNT1	46	P04628
IKGLSLERLPNSIAS	TTC7A	171	Q9ULT0
LNLSKTLSGPLDLEQ	TRARG1	41	Q8IXB3
LVLLELNFLPTTGTK	PSMD8	121	P48556
IPSGLTEAVKSLDLS	TLR2	46	O60603
LREDLLSLQEPGSKT	TG	2751	P01266
TQLSRKLPGTTLTAL	TERT	1101	O14746
SPGSLQRKLSLLEQE	LAMC3	1521	Q9Y6N6
NSLSSLLETLISKEP	MYO1H	576	Q8N1T3