Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transcription coactivator activity	KAT6B CARM1 NCOA2 ARID1B MAML2 NR3C1	9.44e-07	303	23	6	GO:0003713
GeneOntologyMolecularFunction	transcription coregulator activity	KAT6B CARM1 NCOA2 PHF10 ARID1B MAML2 NR3C1	2.23e-06	562	23	7	GO:0003712
GeneOntologyMolecularFunction	chromatin binding	KAT6B NCOA2 PHF10 ZNF431 ARID1B NR3C1	1.48e-04	739	23	6	GO:0003682
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	KAT6B CARM1 NCOA2 PHF10 ARID1B MAML2 NR3C1	2.36e-04	1160	23	7	GO:0030674
GeneOntologyMolecularFunction	molecular adaptor activity	KAT6B CARM1 NCOA2 PHF10 ARID1B MAML2 NR3C1	6.11e-04	1356	23	7	GO:0060090
GeneOntologyMolecularFunction	histone acetyltransferase activity	KAT6B PHF10	1.56e-03	51	23	2	GO:0004402
GeneOntologyMolecularFunction	peptide-lysine-N-acetyltransferase activity	KAT6B PHF10	1.82e-03	55	23	2	GO:0061733
GeneOntologyMolecularFunction	peptide N-acetyltransferase activity	KAT6B PHF10	2.16e-03	60	23	2	GO:0034212
GeneOntologyMolecularFunction	histone modifying activity	KAT6B CARM1 PHF10	2.23e-03	229	23	3	GO:0140993
GeneOntologyMolecularFunction	nuclear receptor coactivator activity	CARM1 NCOA2	2.23e-03	61	23	2	GO:0030374
GeneOntologyMolecularFunction	N-acetyltransferase activity	KAT6B PHF10	3.61e-03	78	23	2	GO:0008080
GeneOntologyMolecularFunction	N-acyltransferase activity	KAT6B PHF10	6.10e-03	102	23	2	GO:0016410
GeneOntologyMolecularFunction	acetyltransferase activity	KAT6B PHF10	6.33e-03	104	23	2	GO:0016407
GeneOntologyBiologicalProcess	negative regulation of synaptic plasticity	UNC13C NR3C1	1.78e-05	6	23	2	GO:0031914
GeneOntologyBiologicalProcess	myosin filament assembly	TMOD1 RAP1GDS1	1.78e-05	6	23	2	GO:0031034
GeneOntologyBiologicalProcess	positive regulation of glucocorticoid receptor signaling pathway	NCOA2 NR3C1	1.78e-05	6	23	2	GO:2000324
GeneOntologyBiologicalProcess	dendrite development	CARM1 LZTS1 PTPRZ1 ARID1B NR3C1	2.90e-05	335	23	5	GO:0016358
GeneOntologyBiologicalProcess	myosin filament organization	TMOD1 RAP1GDS1	4.26e-05	9	23	2	GO:0031033
GeneOntologyBiologicalProcess	negative regulation of dendrite development	CARM1 PTPRZ1	7.80e-05	12	23	2	GO:2000171
GeneOntologyBiologicalProcess	regulation of glucocorticoid receptor signaling pathway	NCOA2 NR3C1	7.80e-05	12	23	2	GO:2000322
GeneOntologyBiologicalProcess	cellular response to hormone stimulus	CARM1 NCOA2 APPL1 ARID1B RAP1GDS1 NR3C1	1.13e-04	727	23	6	GO:0032870
GeneOntologyBiologicalProcess	regulation of intracellular steroid hormone receptor signaling pathway	CARM1 NCOA2 NR3C1	1.21e-04	87	23	3	GO:0033143
GeneOntologyBiologicalProcess	chromatin remodeling	KAT6B CARM1 PHF10 ARID1B TEX15 NR3C1	1.26e-04	741	23	6	GO:0006338
GeneOntologyBiologicalProcess	hormone-mediated signaling pathway	CARM1 NCOA2 APPL1 NR3C1	1.42e-04	244	23	4	GO:0009755
GeneOntologyBiologicalProcess	nuclear receptor-mediated glucocorticoid signaling pathway	NCOA2 NR3C1	1.60e-04	17	23	2	GO:0042921
GeneOntologyBiologicalProcess	positive regulation of intracellular steroid hormone receptor signaling pathway	NCOA2 NR3C1	1.80e-04	18	23	2	GO:0033145
GeneOntologyBiologicalProcess	nuclear receptor-mediated corticosteroid signaling pathway	NCOA2 NR3C1	1.80e-04	18	23	2	GO:0031958
GeneOntologyBiologicalProcess	chromatin organization	KAT6B CARM1 PHF10 ARID1B TEX15 NR3C1	3.53e-04	896	23	6	GO:0006325
GeneOntologyBiologicalProcess	nuclear receptor-mediated steroid hormone signaling pathway	CARM1 NCOA2 NR3C1	4.51e-04	136	23	3	GO:0030518
GeneOntologyBiologicalProcess	regulation of nucleotide-excision repair	PHF10 ARID1B	4.74e-04	29	23	2	GO:2000819
GeneOntologyBiologicalProcess	regulation of double-strand break repair	PHF10 ARID1B TEX15	5.55e-04	146	23	3	GO:2000779
GeneOntologyBiologicalProcess	regulation of dendrite development	CARM1 LZTS1 PTPRZ1	6.00e-04	150	23	3	GO:0050773
GeneOntologyBiologicalProcess	protein-DNA complex organization	KAT6B CARM1 PHF10 ARID1B TEX15 NR3C1	6.31e-04	999	23	6	GO:0071824
GeneOntologyBiologicalProcess	steroid hormone receptor signaling pathway	CARM1 NCOA2 NR3C1	6.60e-04	155	23	3	GO:0043401
GeneOntologyBiologicalProcess	cellular response to peptide hormone stimulus	NCOA2 APPL1 ARID1B RAP1GDS1	7.68e-04	381	23	4	GO:0071375
GeneOntologyBiologicalProcess	response to hormone	CARM1 NCOA2 APPL1 ARID1B RAP1GDS1 NR3C1	7.88e-04	1042	23	6	GO:0009725
GeneOntologyBiologicalProcess	cellular response to angiotensin	ARID1B RAP1GDS1	9.04e-04	40	23	2	GO:1904385
GeneOntologyBiologicalProcess	regulation of G0 to G1 transition	PHF10 ARID1B	9.97e-04	42	23	2	GO:0070316
GeneOntologyBiologicalProcess	G0 to G1 transition	PHF10 ARID1B	1.09e-03	44	23	2	GO:0045023
GeneOntologyBiologicalProcess	response to angiotensin	ARID1B RAP1GDS1	1.41e-03	50	23	2	GO:1990776
GeneOntologyBiologicalProcess	nuclear receptor-mediated signaling pathway	CARM1 NCOA2 NR3C1	1.42e-03	202	23	3	GO:0141193
GeneOntologyBiologicalProcess	chromosome segregation	PHF10 ARID1B TEX15 NR3C1	1.61e-03	465	23	4	GO:0007059
GeneOntologyBiologicalProcess	positive regulation of myoblast differentiation	PHF10 ARID1B	1.64e-03	54	23	2	GO:0045663
GeneOntologyBiologicalProcess	regulation of G1/S transition of mitotic cell cycle	PHF10 APPL1 ARID1B	1.65e-03	213	23	3	GO:2000045
GeneOntologyCellularComponent	npBAF complex	PHF10 ARID1B	1.05e-04	14	23	2	GO:0071564
GeneOntologyCellularComponent	dendritic spine	NCOA2 LZTS1 PTPRZ1 NR3C1	1.30e-04	242	23	4	GO:0043197
GeneOntologyCellularComponent	neuron spine	NCOA2 LZTS1 PTPRZ1 NR3C1	1.41e-04	247	23	4	GO:0044309
GeneOntologyCellularComponent	SWI/SNF complex	PHF10 ARID1B	4.94e-04	30	23	2	GO:0016514
MousePheno	decreased dentate gyrus size	ADCY3 ARID1B	4.36e-05	8	18	2	MP:0012460
Domain	PHD	KAT6B PHF10	3.81e-03	75	23	2	PF00628
Domain	Znf_PHD-finger	KAT6B PHF10	4.22e-03	79	23	2	IPR019787
Domain	ARM-like	ARID1B RAP1GDS1 PPP6R3	4.27e-03	270	23	3	IPR011989
Domain	PHD	KAT6B PHF10	5.32e-03	89	23	2	SM00249
Domain	Znf_PHD	KAT6B PHF10	5.56e-03	91	23	2	IPR001965
Domain	ZF_PHD_2	KAT6B PHF10	6.04e-03	95	23	2	PS50016
Domain	ZF_PHD_1	KAT6B PHF10	6.17e-03	96	23	2	PS01359
Domain	Znf_FYVE_PHD	KAT6B PHF10	1.40e-02	147	23	2	IPR011011
Pathway	PID_AR_TF_PATHWAY	CARM1 NCOA2 NR3C1	4.66e-05	53	19	3	M151
Pathway	PID_AR_PATHWAY	CARM1 NCOA2 APPL1	7.11e-05	61	19	3	M58
Pathway	REACTOME_CIRCADIAN_CLOCK	CARM1 NCOA2 NR3C1	1.07e-04	70	19	3	M938
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	CARM1 NCOA2	2.60e-04	18	19	2	MM15034
Pathway	REACTOME_RORA_ACTIVATES_GENE_EXPRESSION	CARM1 NCOA2	2.60e-04	18	19	2	M26942
Pathway	REACTOME_CHROMATIN_MODIFYING_ENZYMES	KAT6B CARM1 NCOA2 ARID1B	4.18e-04	272	19	4	M29619
Pathway	REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_GENE_EXPRESSION	CARM1 NCOA2	5.92e-04	27	19	2	M26943
Pathway	KEGG_MEDICUS_REFERENCE_ADRB3_UCP1_SIGNALING_PATHWAY	ADCY3 ARID1B	9.97e-04	35	19	2	M47969
Pubmed	Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes.	NCOA2 NR3C1	4.18e-07	2	23	2	23159735
Pubmed	Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations.	NCOA2 NR3C1	4.18e-07	2	23	2	23132854
Pubmed	A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance.	NCOA2 NR3C1	4.18e-07	2	23	2	17635946
Pubmed	A novel mutation of the hGR gene causing Chrousos syndrome.	NCOA2 NR3C1	4.18e-07	2	23	2	26031419
Pubmed	A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: the importance of the C terminus of hGR LBD in conferring transactivational activity.	NCOA2 NR3C1	4.18e-07	2	23	2	15769988
Pubmed	Requirement for multiple domains of the protein arginine methyltransferase CARM1 in its transcriptional coactivator function.	CARM1 NCOA2	4.18e-07	2	23	2	12351636
Pubmed	Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.	NCOA2 NR3C1	4.18e-07	2	23	2	12151000
Pubmed	CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators.	CARM1 NCOA2	1.25e-06	3	23	2	14690606
Pubmed	Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1.	NCOA2 NR3C1	1.25e-06	3	23	2	15557560
Pubmed	The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression.	NCOA2 NR3C1	1.25e-06	3	23	2	16362036
Pubmed	The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2.	CARM1 NCOA2	1.25e-06	3	23	2	11713257
Pubmed	Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells.	NCOA2 NR3C1	1.25e-06	3	23	2	19805480
Pubmed	SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1.	CARM1 NCOA2	1.25e-06	3	23	2	14500758
Pubmed	Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase.	CARM1 NCOA2	1.25e-06	3	23	2	17882261
Pubmed	Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities.	CARM1 NCOA2	2.51e-06	4	23	2	11997499
Pubmed	GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression.	NCOA2 NR3C1	2.51e-06	4	23	2	19074285
Pubmed	Genetic association of a polymorphism of the cAMP-responsive element binding protein-binding protein with steroid-induced osteonecrosis after kidney transplantation.	NCOA2 NR3C1	2.51e-06	4	23	2	17704997
Pubmed	Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death.	CARM1 NCOA2	2.51e-06	4	23	2	26267537
Pubmed	Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes.	CARM1 NCOA2	4.18e-06	5	23	2	18511550
Pubmed	Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle.	NCOA2 NR3C1	4.18e-06	5	23	2	23950223
Pubmed	GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors.	NCOA2 NR3C1	4.18e-06	5	23	2	8643509
Pubmed	Regulation of transcription by a protein methyltransferase.	CARM1 NCOA2	4.18e-06	5	23	2	10381882
Pubmed	Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly.	CARM1 NCOA2	6.26e-06	6	23	2	16923966
Pubmed	Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination.	CARM1 NCOA2	6.26e-06	6	23	2	15731352
Pubmed	Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex.	NCOA2 NR3C1	8.77e-06	7	23	2	9590696
Pubmed	An additional region of coactivator GRIP1 required for interaction with the hormone-binding domains of a subset of nuclear receptors.	NCOA2 NR3C1	8.77e-06	7	23	2	9920895
Pubmed	Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities.	CARM1 NCOA2	1.17e-05	8	23	2	11050077
Pubmed	Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.	ARID1B MAML2	1.50e-05	9	23	2	19176441
Pubmed	Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity.	CARM1 NCOA2	1.50e-05	9	23	2	14966289
Pubmed	Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1.	CARM1 NCOA2	1.50e-05	9	23	2	16344550
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	NCOA2 ARID1B NR3C1	1.86e-05	78	23	3	28611094
Pubmed	The Hippocampal Response to Acute Corticosterone Elevation Is Altered in a Mouse Model for Angelman Syndrome.	NCOA2 NR3C1	2.29e-05	11	23	2	36613751
Pubmed	Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex.	NCOA2 NR3C1	2.29e-05	11	23	2	11704662
Pubmed	Separation and Quantification of Some Alkaloids from Fumaria parviflora by Capillary Isotachophoresis1.	PHF10 ARID1B	3.25e-05	13	23	2	17340523
Pubmed	Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140.	NCOA2 NR3C1	3.25e-05	13	23	2	11266503
Pubmed	The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes.	PHF10 ARID1B	5.66e-05	17	23	2	11078522
Pubmed	Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort.	CARM1 NCOA2	5.66e-05	17	23	2	19183483
Pubmed	BAF complexes facilitate decatenation of DNA by topoisomerase IIα.	PHF10 ARID1B	6.36e-05	18	23	2	23698369
Pubmed	Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.	PHF10 ARID1B	7.10e-05	19	23	2	12110891
Pubmed	Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction.	PHF10 ARID1B	7.10e-05	19	23	2	16932743
Pubmed	Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix.	PHF10 NR3C1	7.89e-05	20	23	2	9128241
Pubmed	A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.	PHF10 ADCY3	9.59e-05	22	23	2	21980299
Pubmed	Diversity and specialization of mammalian SWI/SNF complexes.	PHF10 ARID1B	1.05e-04	23	23	2	8804307
Pubmed	FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.	PHF10 ARID1B	1.05e-04	23	23	2	30962207
Pubmed	CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.	CARM1 NR3C1	1.14e-04	24	23	2	20530543
Pubmed	Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.	TMOD1 NR3C1	1.14e-04	24	23	2	36109497
Pubmed	The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.	PHF10 ARID1B	1.14e-04	24	23	2	12215535
Pubmed	SWI/SNF chromatin remodeling and cancer.	PHF10 ARID1B	1.14e-04	24	23	2	11790558
Pubmed	Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.	PHF10 ARID1B	1.14e-04	24	23	2	10078207
Pubmed	Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF.	PHF10 ARID1B	1.35e-04	26	23	2	10778858
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	KAT6B PHF10 ARID1B	1.50e-04	157	23	3	30186101
Pubmed	REST repression of neuronal genes requires components of the hSWI.SNF complex.	PHF10 ARID1B	1.56e-04	28	23	2	12192000
Pubmed	Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.	CARM1 NCOA2	1.56e-04	28	23	2	24880616
Pubmed	Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.	OLFM4 ADCY3	1.56e-04	28	23	2	24861553
Pubmed	An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.	PHF10 ARID1B	1.68e-04	29	23	2	19279220
Pubmed	Mammalian SWI/SNF collaborates with a polycomb-associated protein to regulate male germline transcription in the mouse.	PHF10 ARID1B	1.80e-04	30	23	2	31043422
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	CARM1 NCOA2 ARID1B RAP1GDS1	2.14e-04	457	23	4	32344865
Pubmed	The core SWI/SNF catalytic subunit Brg1 regulates nephron progenitor cell proliferation and differentiation.	PHF10 ARID1B	2.46e-04	35	23	2	32504627
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	CARM1 APPL1 RAP1GDS1 CRTAP PPP6R3 NR3C1	2.90e-04	1455	23	6	22863883
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KAT6B ARID1B MAML2 PPP6R3	3.72e-04	529	23	4	14621295
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	CRTAP PPP6R3 NR3C1	4.88e-04	235	23	3	28378594
Pubmed	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	CARM1 NCOA2 NR3C1	5.84e-04	250	23	3	18660489
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	PHF10 APPL1 RAP1GDS1 PPP6R3	6.13e-04	604	23	4	38803224
Pubmed	New nomenclature for chromatin-modifying enzymes.	KAT6B NCOA2	6.53e-04	57	23	2	18022353
Interaction	SMARCE1 interactions	CARM1 NCOA2 PHF10 ARID1B NR3C1	1.54e-05	287	23	5	int:SMARCE1
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	KAT6B NCOA2	1.26e-04	17	18	2	486
GeneFamily	PHD finger proteins	KAT6B PHF10	3.56e-03	90	18	2	88
ToppCell	nucseq\|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NCOA2 ARID1B MAML2 PPP6R3	2.73e-06	193	23	4	779276e775cb2492e8dd36436295a536084a6415
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	NCOA2 ARID1B MAML2 PPP6R3	3.08e-06	199	23	4	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PHF10 ADCY3 TEX15	4.58e-05	136	23	3	a2063abe2d7c3277bfbe1514c8c66363cf04b248
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PHF10 ADCY3 TEX15	4.68e-05	137	23	3	8e2fa2ef8becace96a68bb85c002329110902fbb
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TMOD1 LZTS1 ADCY3	6.88e-05	156	23	3	6365b69ede98bc866e996bc52736b00401aacf6f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TMOD1 LZTS1 ADCY3	7.01e-05	157	23	3	bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCell	Endothelial-B-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	OLFM4 MMRN1 TMOD1	8.57e-05	168	23	3	4977c3837fbb1f36c89fddd5764e37290ac25ad8
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_LINC00507_CTXN3\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LZTS1 MAML2 TEX15	1.00e-04	177	23	3	96d639407f79669f3990138793d157b94273581c
ToppCell	COVID-19-kidney-vSMC/Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	TMOD1 LZTS1 ADCY3	1.03e-04	179	23	3	111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCell	RA-07._Pericyte\|RA / Chamber and Cluster_Paper	LZTS1 ADCY3 MAML2	1.07e-04	181	23	3	8dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCell	RA-07._Pericyte\|World / Chamber and Cluster_Paper	LZTS1 ADCY3 MAML2	1.09e-04	182	23	3	2075efeae633550fb2eb026d0dfd741c8252482e
ToppCell	LA-07._Pericyte\|World / Chamber and Cluster_Paper	LZTS1 ADCY3 MAML2	1.10e-04	183	23	3	e3835db4795362b0442d5893baf2a78efcc20428
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TMOD1 LZTS1 ADCY3	1.12e-04	184	23	3	102b6f621a5b551e622f97b12d787c080b052a72
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TMOD1 LZTS1 ADCY3	1.12e-04	184	23	3	689a8af81a79a4bb3123cfa01958c953eab5de98
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	LZTS1 ADCY3 MAML2	1.12e-04	184	23	3	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TMOD1 LZTS1 ADCY3	1.12e-04	184	23	3	327ff3ac8d2fecdd5d242bdc34f0dfdb1c59a68b
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	LZTS1 ADCY3 MAML2	1.14e-04	185	23	3	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	LV-07._Pericyte\|LV / Chamber and Cluster_Paper	LZTS1 ADCY3 MAML2	1.14e-04	185	23	3	acb38eba871ec72f2a8136a33b87d33b8c85465d
ToppCell	RV-07._Pericyte\|RV / Chamber and Cluster_Paper	LZTS1 ADCY3 MAML2	1.16e-04	186	23	3	c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCell	normal_Lung-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	PHF10 UBQLNL ARID1B	1.18e-04	187	23	3	a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCell	RV-07._Pericyte\|World / Chamber and Cluster_Paper	LZTS1 ADCY3 MAML2	1.18e-04	187	23	3	dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCell	normal_Lung-Myeloid_cells-pDCs\|normal_Lung / Location, Cell class and cell subclass	PHF10 UBQLNL ARID1B	1.18e-04	187	23	3	d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MMRN1 TMOD1 UNC13C	1.21e-04	189	23	3	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 LZTS1 ADCY3	1.21e-04	189	23	3	fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCell	renal_medulla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	NCOA2 ARID1B MAML2	1.21e-04	189	23	3	830d9cd0dd706bce22eb2416f07b2c31c870a05a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 LZTS1 ADCY3	1.23e-04	190	23	3	5681c211baeed4af82a2bbc13420f6a7b487581c
ToppCell	COVID-19-kidney-vSMC/Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	TMOD1 LZTS1 ADCY3	1.25e-04	191	23	3	fad8eaa536001b911d05ae2b12150c2398cc6f88
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KAT6B MMRN1 UNC13C	1.33e-04	195	23	3	d70b49f6b9c6c4422adb2936c837a1af7569fb0a
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	NCOA2 ARID1B MAML2	1.35e-04	196	23	3	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TMOD1 LZTS1 ADCY3	1.37e-04	197	23	3	cfb3dc4b401800e33c82cfc3baee69dbbd16ac8c
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	NCOA2 ARID1B MAML2	1.39e-04	198	23	3	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	KAT6B LZTS1 PTPRZ1	1.39e-04	198	23	3	6d12ecaa9532c134d9c4562534dcb59a6420b4d3
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	KAT6B LZTS1 PTPRZ1	1.39e-04	198	23	3	7943e4f67c3d6efb5c8b00aa0ff3cfe7be10c48d
ToppCell	Thalamus\|World / BrainAtlas - Mouse McCarroll V32	UNC13C TEX15	1.61e-03	116	23	2	5ddfb2dd5459ff6d7ae38163a38eae64fda283b7
ToppCell	Globus_pallidus\|World / BrainAtlas - Mouse McCarroll V32	UNC13C PPP6R3	1.89e-03	126	23	2	44b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Mme_Fam114a1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	OLFM4 UNC13C	2.11e-03	133	23	2	fc319644868078ea0f88a71d55f5e858c6848b50
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	APPL1 MAML2	2.17e-03	135	23	2	b128596653a5e3b64ed7f657bbfeda35438e2e48
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRZ1 UNC13C	2.23e-03	137	23	2	4dcb15de821439011df1bb0bbd7682d674bd725d
ToppCell	facs-Marrow-B-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRZ1 UNC13C	2.23e-03	137	23	2	c05ceeb7b483324604cb3f647d2da2b3786071b1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_atypical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	2.60e-03	148	23	2	b7b5521162effc1024e7c399f690cd86d0b2f750
ToppCell	COVID-19-kidney-Technical/muscle\|kidney / Disease (COVID-19 only), tissue and cell type	TEX15 LRRC74A	2.60e-03	148	23	2	0dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor\|bone_marrow / Manually curated celltypes from each tissue	MMRN1 UNC13C	2.63e-03	149	23	2	078e1e5765e476ba85c23fb8f6892b6698cbcbdb
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	2.67e-03	150	23	2	8645b9c7f9511ed6cc9afe04440c2873a3094150
ToppCell	Basal_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	PTPRZ1 UNC13C	2.74e-03	152	23	2	72499e4d2b374ef5f1621c89d94727ecf4bd4d5d
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OLFM4 UNC13C	2.77e-03	153	23	2	3b1b0cc8e9dd2b1484649789330713282ee44414
ToppCell	CV-Healthy-3\|Healthy / Virus stimulation, Condition and Cluster	PHF10 ADCY3	2.81e-03	154	23	2	26bf81a86700db7e65c2384ffe94ed4253ea4047
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	2.81e-03	154	23	2	d76fd51a4587decbfe1dde1c8a9b880c5fa18e4a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	2.81e-03	154	23	2	b6e982e341c6cfb6ff80a318078fcb10c36d182f
ToppCell	COVID_non-vent-Myeloid-Monocytic-SC_&_Eosinophil\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	MMRN1 TMOD1	2.95e-03	158	23	2	0d4fe87fc7901dd5f9c004e91708a03cafdb4ad9
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-basal_intermediate_\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	PTPRZ1 LRRC74A	2.95e-03	158	23	2	98712ed7e8e65e8c5ff9318cf0e0a04e271a055d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	2.99e-03	159	23	2	5ca96db4281abb5f646150ccf36adc66ab201c78
ToppCell	ICU-SEP-Lymphocyte-T_NK-CD4_TEM\|ICU-SEP / Disease, Lineage and Cell Type	LZTS1 UBQLNL	3.06e-03	161	23	2	ae6c9afc3c928124993686a82d37d23138322bc1
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.10e-03	162	23	2	f1851a173d3bcca2981d934161ec85d1cc0af5a2
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.10e-03	162	23	2	c7114e24cb5525abb9780ca3d35dbcc4eabd4b64
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.10e-03	162	23	2	5d902bb31e691aea9749617cc88303c2448f24b8
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	OLFM4 CARM1	3.10e-03	162	23	2	f0a92c92c3a6cf9fa11fb279a584e7f328cb7d43
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY3 RAP1GDS1	3.14e-03	163	23	2	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRZ1 MAML2	3.14e-03	163	23	2	f6847f47a8856c0d4136c1af317432d45eccfde9
ToppCell	5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRZ1 MAML2	3.14e-03	163	23	2	a1fbefe53523a9879a4d4b493071059798b5f917
ToppCell	5'-Airway_Nasal_SMG-Epithelial\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRZ1 MAML2	3.14e-03	163	23	2	454a5e87e2f9f66e38cc5aa1b433c47b54c9be42
ToppCell	5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRZ1 MAML2	3.14e-03	163	23	2	be6cc44df9a2b10dce1a353717c279c3558f8fec
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY3 RAP1GDS1	3.14e-03	163	23	2	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	5'-Airway_Nasal_SMG\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRZ1 MAML2	3.14e-03	163	23	2	d8450bf9c6d2ec5dd1472952c9e65f82f995337a
ToppCell	5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTPRZ1 MAML2	3.14e-03	163	23	2	d9bd9d90cfa4e85d5ea51f8f3ee14a700571f508
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TMOD1 LZTS1	3.14e-03	163	23	2	8f24cef152f5965727bbeee116bd26c75cbba82a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.18e-03	164	23	2	43630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MMRN1 TMOD1	3.18e-03	164	23	2	1a1795969673232191425dde84ab24ee6a98143f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.18e-03	164	23	2	46208f18325976c89f572f6627aea0582142b92d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.18e-03	164	23	2	108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MMRN1 TMOD1	3.18e-03	164	23	2	8f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.18e-03	164	23	2	f6a961fa2002da7d9679f32af99e1314c0593ef9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MMRN1 TMOD1	3.18e-03	164	23	2	a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCell	Endothelial-B-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	MMRN1 TMOD1	3.22e-03	165	23	2	b6893882472aeb0d18e26f47eaec9d53688afcde
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRZ1 UNC13C	3.22e-03	165	23	2	dc570154baed59ed109e5369589448e075ba66a9
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.22e-03	165	23	2	9de841c1c95967c562720feba930246debc626fd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.22e-03	165	23	2	cd8de98af8a1a8a6c81d71fae807cc07f319f4c9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.22e-03	165	23	2	4f83ac71efc57be3668d8db1e62bad05dc6a5e2b
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.22e-03	165	23	2	cdc94a640ec01c6892521bcd6f0ee0a66ff23866
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.22e-03	165	23	2	a612a7d3a5415ecacc3df8fbff0ce498f982aad0
ToppCell	356C-Fibroblasts-Fibroblast-D-\|356C / Donor, Lineage, Cell class and subclass (all cells)	MMRN1 TMOD1	3.25e-03	166	23	2	7c2eee0a4f45795a956acf936b85bdb35f1b1624
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|356C / Donor, Lineage, Cell class and subclass (all cells)	MAML2 PPP6R3	3.25e-03	166	23	2	c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCell	356C-Fibroblasts-Fibroblast-D\|356C / Donor, Lineage, Cell class and subclass (all cells)	MMRN1 TMOD1	3.25e-03	166	23	2	7286a37b2827f3747469ffd0d76cbe81116db7ee
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_Erythro-Mega\|bone_marrow / Manually curated celltypes from each tissue	MMRN1 TEX15	3.25e-03	166	23	2	a853005a5587d42daecdf2e23a93109919021a4f
ToppCell	Basal_cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	PTPRZ1 UNC13C	3.25e-03	166	23	2	aea2ae12e4746149ebc6da063ef694381c098f80
ToppCell	Endothelial-B-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	MMRN1 TMOD1	3.29e-03	167	23	2	6a03d16165e0b003092c39972928981abd4a75aa
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADCY3 NR3C1	3.29e-03	167	23	2	4b6853efefea5178280ba7c31facda0fbd1cc469
ToppCell	facs-Lung-EPCAM-24m-Endothelial-Lymphatic_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARM1 MMRN1	3.29e-03	167	23	2	961e722442d786ab15d1e490941d2be265a9057a
ToppCell	facs-Lung-EPCAM-24m-Endothelial-endothelial_cell_of_lymphatic_vessel\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CARM1 MMRN1	3.29e-03	167	23	2	3760efc35d4e7e9c2da1a20f9795ddea397e2206
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.29e-03	167	23	2	7cb1b11e8e24a10115e46ffbb74889e672a7a026
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.29e-03	167	23	2	bb53a478b5d821d6d82c15bc4ed075b67682457c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LZTS1 ADCY3	3.29e-03	167	23	2	e228b8373ffd4436e6b944e26d0fadf3ac289b21
ToppCell	(3)_MNP-(3)_DC_plasmacytoid\|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)	UBQLNL NR3C1	3.33e-03	168	23	2	13c160ea1a19b47d2e7e2dae818c8dcde4e3e377
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TMOD1 TEX15	3.33e-03	168	23	2	4b2d29a7843bf45922038c093ca7ec0600756adc
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-OPC_related\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	ZNF431 MAML2	3.37e-03	169	23	2	29db25e7c5f31d98a08a35d7ec5ade203242bc50
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-OPC_related-Oligodendrocyte/OPC\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	ZNF431 MAML2	3.37e-03	169	23	2	b1611e61f635f8f9b87250e026ad30999cbee041
ToppCell	AT1-AT2_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	OLFM4 ZNF431	3.37e-03	169	23	2	815474855a70498a74e52f6583113c63b7267a0c
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KAT6B MAML2	3.37e-03	169	23	2	6614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KAT6B RAP1GDS1	3.37e-03	169	23	2	8caf7996796a2e2716e3855de855c903d6126bf2
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KAT6B MAML2	3.37e-03	169	23	2	665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MMRN1 TMOD1	3.41e-03	170	23	2	dcc64b73134e89ae37990d4878813b86ce91dae9
Drug	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	CARM1 NCOA2 APPL1 NR3C1	3.31e-05	185	23	4	ctd:C045037
Drug	Debrisoquin sulfate [581-88-4]; Up 200; 9uM; MCF7; HT_HG-U133A	KAT6B CARM1 TMOD1 NR3C1	4.15e-05	196	23	4	5288_UP
Drug	rottlerin; Down 200; 10uM; MCF7; HT_HG-U133A_EA	KAT6B APPL1 PPP6R3 NR3C1	4.32e-05	198	23	4	914_DN
Drug	4,4'-bisphenol F	NCOA2 ADCY3 NR3C1	6.03e-05	76	23	3	ctd:C008745
Drug	corticoid	NCOA2 NR3C1	6.40e-05	12	23	2	CID000066249
Drug	dexamethasone oxetanone	NCOA2 NR3C1	6.40e-05	12	23	2	CID000063042
Drug	C11998	NCOA2 NR3C1	1.02e-04	15	23	2	CID005282036
Drug	dexamethasone 21-mesylate	NCOA2 NR3C1	1.16e-04	16	23	2	CID000063041
Drug	AC1L9FY1	CARM1 NCOA2 ADCY3	1.41e-04	101	23	3	CID000444218
Drug	methylparaben	NCOA2 NR3C1	2.03e-04	21	23	2	ctd:C015358
Drug	1-alpha-25-dihydroxycholecalciferol	KAT6B CARM1 TMOD1 LZTS1 PTPRZ1 NR3C1	2.24e-04	909	23	6	CID000002524
Drug	AC1L2E0P	KAT6B CARM1 NCOA2 NR3C1	2.34e-04	307	23	4	CID000019390
Drug	NSC325316	NCOA2 NR3C1	2.44e-04	23	23	2	CID000331608
Drug	AC1L1CGL	NCOA2 APPL1	3.37e-04	27	23	2	CID000001889
Drug	SM-10906	KAT6B ADCY3	3.37e-04	27	23	2	CID006442261
Drug	PeCDD	CARM1 APPL1	3.37e-04	27	23	2	CID000038439
Drug	androstenol	NCOA2 NR3C1	3.37e-04	27	23	2	CID000101989
Drug	AC1NBTRA	OLFM4 ADCY3	4.75e-04	32	23	2	CID004473609
Drug	paracrystals	KAT6B ADCY3 CRTAP	5.54e-04	161	23	3	CID000004685
Drug	Cyproterone Acetate	NCOA2 NR3C1	5.69e-04	35	23	2	ctd:D017373
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	KAT6B NCOA2 ADCY3	6.71e-04	172	23	3	3428_DN
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A	KAT6B NCOA2 ADCY3	7.18e-04	176	23	3	7499_DN
Drug	propylparaben	NCOA2 NR3C1	7.44e-04	40	23	2	ctd:C006068
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A	KAT6B NCOA2 NR3C1	7.78e-04	181	23	3	3643_DN
Drug	Azaguanine-8 [134-58-7]; Down 200; 26.2uM; PC3; HT_HG-U133A	KAT6B NCOA2 APPL1	7.78e-04	181	23	3	1791_DN
Drug	platinum	OLFM4 TMOD1 ADCY3	8.04e-04	183	23	3	CID000023939
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	KAT6B NCOA2 LHPP	8.55e-04	187	23	3	6671_DN
Drug	7 alpha, 17 alpha-dimethyl-19-nortestosterone	NCOA2 NR3C1	9.00e-04	44	23	2	CID000019454
Drug	Clotrimazole [23593-75-1]; Down 200; 11.6uM; MCF7; HT_HG-U133A	KAT6B NCOA2 NR3C1	9.23e-04	192	23	3	6207_DN
Drug	Iohexol [66108-95-0]; Down 200; 4.8uM; MCF7; HT_HG-U133A	KAT6B NCOA2 TMOD1	9.37e-04	193	23	3	3322_DN
Drug	Chelidonine monohydrate (+) [476-32-4]; Down 200; 10.8uM; MCF7; HT_HG-U133A	NCOA2 ADCY3 RAP1GDS1	9.51e-04	194	23	3	2779_DN
Drug	Propoxycaine hydrochloride [550-83-4]; Down 200; 12uM; MCF7; HT_HG-U133A	NCOA2 TMOD1 NR3C1	9.66e-04	195	23	3	6803_DN
Drug	Suloctidil [54063-56-8]; Down 200; 11.8uM; MCF7; HT_HG-U133A	TMOD1 ADCY3 NR3C1	9.66e-04	195	23	3	5021_DN
Drug	Meclozine dihydrochloride [1104-22-9]; Down 200; 8.6uM; PC3; HT_HG-U133A	NCOA2 ADCY3 NR3C1	9.66e-04	195	23	3	4646_DN
Drug	Danazol [17230-88-5]; Down 200; 11.8uM; MCF7; HT_HG-U133A	APPL1 PPP6R3 NR3C1	9.66e-04	195	23	3	5315_DN
Drug	Pirenperone [ 75444-65-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A	NCOA2 TMOD1 NR3C1	9.80e-04	196	23	3	5639_DN
Drug	Mevalonic-D, L acid lactone [674-26-0]; Down 200; 30.8uM; HL60; HT_HG-U133A	KAT6B NCOA2 PPP6R3	9.80e-04	196	23	3	2718_DN
Drug	Gemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A	NCOA2 TMOD1 NR3C1	9.80e-04	196	23	3	5488_UP
Drug	Pivampicillin [33817-20-8]; Up 200; 8.6uM; MCF7; HT_HG-U133A	APPL1 TEX15 NR3C1	9.80e-04	196	23	3	3506_UP
Drug	Amphotericin B [1397-89-3]; Up 200; 4.4uM; HL60; HT_HG-U133A	NCOA2 TMOD1 TEX15	9.80e-04	196	23	3	2441_UP
Drug	LY 294002; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	APPL1 ADCY3 PPP6R3	9.80e-04	196	23	3	1054_DN
Drug	Metolazone [17560-51-9]; Down 200; 11uM; HL60; HG-U133A	NCOA2 APPL1 NR3C1	9.94e-04	197	23	3	2014_DN
Drug	(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Down 200; 11uM; MCF7; HT_HG-U133A	NCOA2 LHPP NR3C1	9.94e-04	197	23	3	5009_DN
Drug	Paclitaxel [33069-62-4]; Down 200; 4.6uM; MCF7; HT_HG-U133A	NCOA2 ADCY3 NR3C1	9.94e-04	197	23	3	5320_DN
Drug	Cefotiam hydrochloride; Down 200; 7.2uM; MCF7; HT_HG-U133A	KAT6B TMOD1 NR3C1	9.94e-04	197	23	3	5361_DN
Drug	Nabumetone [42924-53-8]; Down 200; 17.6uM; MCF7; HT_HG-U133A	NCOA2 TMOD1 APPL1	9.94e-04	197	23	3	6487_DN
Drug	Isoxicam [34552-84-6]; Down 200; 12uM; MCF7; HT_HG-U133A	ADCY3 PPP6R3 NR3C1	1.01e-03	198	23	3	7028_DN
Drug	Reserpinic acid hydrochloride; Down 200; 9.2uM; MCF7; HT_HG-U133A	NCOA2 LHPP ADCY3	1.01e-03	198	23	3	7323_DN
Drug	Midecamycin [35457-80-8]; Down 200; 5uM; MCF7; HT_HG-U133A	LHPP RAP1GDS1 NR3C1	1.01e-03	198	23	3	5345_DN
Drug	Amyleine hydrochloride [532-59-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	NCOA2 ADCY3 NR3C1	1.01e-03	198	23	3	1491_DN
Drug	Pizotifen malate [5189-11-7]; Up 200; 9.4uM; MCF7; HT_HG-U133A	NCOA2 TEX15 NR3C1	1.01e-03	198	23	3	5491_UP
Drug	nordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A	KAT6B ADCY3 NR3C1	1.01e-03	198	23	3	6983_DN
Disease	alcohol use disorder (implicated_via_orthology)	PHF10 UNC13C ARID1B	4.57e-04	195	23	3	DOID:1574 (implicated_via_orthology)
Disease	multiple sclerosis symptom measurement	NCOA2 UNC13C	5.89e-04	46	23	2	EFO_0803536
Disease	multiple sclerosis	NCOA2 ADCY3 CRTAP NR3C1	1.06e-03	594	23	4	MONDO_0005301
Disease	methadone dose measurement	MAML2 TEX15	1.07e-03	62	23	2	EFO_0007907
Disease	Prostatic Neoplasms	NCOA2 TMOD1 LZTS1 NR3C1	1.21e-03	616	23	4	C0033578
Disease	Malignant neoplasm of prostate	NCOA2 TMOD1 LZTS1 NR3C1	1.21e-03	616	23	4	C0376358
Disease	urate measurement, bone density	KAT6B LZTS1 MAML2 CRTAP	1.24e-03	619	23	4	EFO_0003923, EFO_0004531
Disease	unipolar depression	OLFM4 NCOA2 APPL1 LHPP CRTAP	2.06e-03	1206	23	5	EFO_0003761
Disease	visual epilepsy (biomarker_via_orthology)	PTPRZ1 NR3C1	2.23e-03	90	23	2	DOID:11832 (biomarker_via_orthology)
Disease	susceptibility to pneumonia measurement	OLFM4 ADCY3	2.59e-03	97	23	2	EFO_0008410
Disease	status epilepticus (biomarker_via_orthology)	PTPRZ1 NR3C1	2.75e-03	100	23	2	DOID:1824 (biomarker_via_orthology)
Disease	response to vaccine	OLFM4 UNC13C	4.05e-03	122	23	2	EFO_0004645
Disease	waist circumference	ADCY3 UNC13C TEX15	4.35e-03	429	23	3	EFO_0004342
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Positive	KAT6B MAML2	4.66e-03	131	23	2	C4704862
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Negative	KAT6B MAML2	4.66e-03	131	23	2	C4552091
Disease	Juvenile arthritis	KAT6B MAML2	4.66e-03	131	23	2	C3495559
Disease	Juvenile psoriatic arthritis	KAT6B MAML2	4.66e-03	131	23	2	C3714758
Disease	insomnia measurement	OLFM4 MMRN1 TEX15	4.76e-03	443	23	3	EFO_0007876
Disease	severe acute respiratory syndrome, COVID-19	NCOA2 UNC13C MAML2	4.88e-03	447	23	3	EFO_0000694, MONDO_0100096
Disease	Juvenile-Onset Still Disease	KAT6B MAML2	4.94e-03	135	23	2	C0087031
Disease	lung non-small cell carcinoma (is_implicated_in)	NCOA2 ARID1B	5.22e-03	139	23	2	DOID:3908 (is_implicated_in)
Disease	attention function measurement	NCOA2 LZTS1	5.90e-03	148	23	2	EFO_0007636
Disease	nasopharyngeal neoplasm	OLFM4 ADCY3	6.13e-03	151	23	2	EFO_0004252

Protein segments in the cluster

Peptide	Gene	Start	Entry
MYNMQYSSQQQEMYN	ARID1B	1461	Q8NFD5
AYNVNSVNMNMNTLN	KAT6B	1976	Q8WYB5
QYQKQLQQSYVAMYQ	LZTS1	541	Q9Y250
NQSNFQKMYQMFNET	MMRN1	816	Q13201
TAISNYMNQLYQAMH	APPL1	31	Q9UKG1
QFYGYLSQQQNMMQD	CARM1	151	Q86X55
MLQENYYLQEMNISN	LRRC74A	156	Q0VAA2
MYHYDMNTASLSQQQ	NR3C1	331	P04150
SYQNMNNAFQVLMEL	LHPP	131	Q9H008
MLMDYLQNNFREQQY	PTPRZ1	276	P23471
YMNSQQSLLNQQLMG	MAML2	741	Q8IZL2
HYKEYSQMQQQNTQK	PHF10	176	Q8WUB8
QNDKVMQQNLVYYQY	CRTAP	326	O75718
MLMNYSNENDSLQAQ	RAP1GDS1	161	P52306
QKDQQQFNTMYMYRH	ADCY3	301	O60266
NNMYVNMYNTGNIAR	OLFM4	336	Q6UX06
GQQANTSMYSNNMNI	NCOA2	1376	Q15596
QQNLYMNVMLENYKN	ZNF431	56	Q8TF32
SNELYQNQNQLSMMY	UNC13C	746	Q8NB66
QNQNQLSMMYRSQSE	UNC13C	751	Q8NB66
GMHTLMSNQQYYQAL	TMOD1	136	P28289
GQNYADINDQMLNSM	UBQLNL	271	Q8IYU4
YFQMLQDNNMDNIFI	TEX15	2021	Q9BXT5
SLQQAFSDYQMQQMT	PPP6R3	541	Q5H9R7