Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentlate endosome lumen

PGA4 GAPDH PGA5 PGA3

2.59e-07111134GO:0031906
GeneOntologyCellularComponentmultivesicular body lumen

PGA4 PGA5 PGA3

5.30e-0671133GO:0097486
GeneOntologyCellularComponentendosome lumen

PGA4 GAPDH PGA5 PGA3

8.49e-05431134GO:0031904
DomainAspartic_peptidase_N

PGA4 PGA5 PGA3

7.42e-0671133IPR012848
DomainA1_Propeptide

PGA4 PGA5 PGA3

7.42e-0671133PF07966
DomainMacrogloblnA2_thiol-ester-bond

A2M CD109 A2ML1

1.18e-0581133IPR019565
DomainThiol-ester_cl

A2M CD109 A2ML1

1.18e-0581133PF10569
DomainMacrogloblnA2_CS

A2M CD109 A2ML1

1.18e-0581133IPR019742
DomainA2M_N_2

A2M CD109 A2ML1

1.18e-0581133SM01359
Domain-

A2M CD109 A2ML1

1.18e-05811332.60.40.690
DomainA2M_recep

A2M CD109 A2ML1

1.18e-0581133SM01361
DomainA2M

A2M CD109 A2ML1

1.18e-0581133SM01360
DomainBEACH

WDR81 LYST LRBA

1.76e-0591133PS50197
DomainBeach

WDR81 LYST LRBA

1.76e-0591133PF02138
Domain-

WDR81 LYST LRBA

1.76e-05911331.10.1540.10
DomainBeach

WDR81 LYST LRBA

1.76e-0591133SM01026
DomainBEACH_dom

WDR81 LYST LRBA

1.76e-0591133IPR000409
DomainAspartic_peptidase_A1

PGA4 PGA5 PGA3

2.51e-05101133IPR001461
DomainA2M

A2M CD109 A2ML1

2.51e-05101133PF00207
DomainA2M_N_2

A2M CD109 A2ML1

2.51e-05101133IPR011625
DomainA2M_comp

A2M CD109 A2ML1

2.51e-05101133IPR011626
DomainA2M_recep

A2M CD109 A2ML1

2.51e-05101133PF07677
DomainA2M_comp

A2M CD109 A2ML1

2.51e-05101133PF07678
DomainA2M_N

A2M CD109 A2ML1

2.51e-05101133PF01835
DomainA2M_N

A2M CD109 A2ML1

2.51e-05101133IPR002890
DomainA-macroglobulin_rcpt-bd

A2M CD109 A2ML1

2.51e-05101133IPR009048
DomainPEPTIDASE_A1

PGA4 PGA5 PGA3

2.51e-05101133IPR033121
DomainALPHA_2_MACROGLOBULIN

A2M CD109 A2ML1

2.51e-05101133PS00477
DomainA2M_N_2

A2M CD109 A2ML1

2.51e-05101133PF07703
DomainAsp

PGA4 PGA5 PGA3

2.51e-05101133PF00026
DomainPEPTIDASE_A1

PGA4 PGA5 PGA3

2.51e-05101133PS51767
DomainMacroglobln_a2

A2M CD109 A2ML1

2.51e-05101133IPR001599
Domain-

PGA4 PGA5 PGA3

4.56e-051211332.40.70.10
Domain-

A2M CD109 A2ML1

4.56e-051211331.50.10.20
DomainASP_PROTEASE

PGA4 PGA5 PGA3

4.56e-05121133PS00141
DomainAspartic_peptidase_AS

PGA4 PGA5 PGA3

5.90e-05131133IPR001969
DomainBromodomain

ZMYND8 PBRM1 BRDT TAF1

8.00e-05381134PF00439
DomainBROMODOMAIN_2

ZMYND8 PBRM1 BRDT TAF1

1.08e-04411134PS50014
DomainBromodomain

ZMYND8 PBRM1 BRDT TAF1

1.19e-04421134IPR001487
DomainBROMO

ZMYND8 PBRM1 BRDT TAF1

1.19e-04421134SM00297
Domain-

ZMYND8 PBRM1 BRDT TAF1

1.19e-044211341.20.920.10
DomainPeptidase_aspartic_dom

PGA4 PGA5 PGA3

1.38e-04171133IPR021109
DomainTerpenoid_cyclase/PrenylTrfase

A2M CD109 A2ML1

1.65e-04181133IPR008930
DomainEFG_IV

GFM2 EFTUD2

2.16e-0441132SM00889
DomainEFG_IV

GFM2 EFTUD2

2.16e-0441132PF03764
DomainTransl_elong_EFG/EF2_IV

GFM2 EFTUD2

2.16e-0441132IPR005517
DomainEFG_II

GFM2 EFTUD2

3.59e-0451132PF14492
DomainVWA

VWA8 COL6A5 INTS6 CLCA2

3.66e-04561134PF00092
DomainBromodomain_CS

PBRM1 BRDT TAF1

5.07e-04261133IPR018359
DomainEFG_C

GFM2 EFTUD2

5.36e-0461132PF00679
DomainPH_BEACH

LYST LRBA

5.36e-0461132PF14844
DomainEFG_III-V

GFM2 EFTUD2

5.36e-0461132IPR009022
DomainEFG_C

GFM2 EFTUD2

5.36e-0461132SM00838
Domain-

GFM2 EFTUD2

7.47e-04711323.30.70.240
DomainEFG_V

GFM2 EFTUD2

7.47e-0471132IPR000640
DomainAcyl-CoA-binding_protein

MYO10 ACBD4

9.92e-0481132IPR000582
DomainPH-BEACH_dom

LYST LRBA

9.92e-0481132IPR023362
Domain-

LYST LRBA

9.92e-04811322.30.29.40
DomainPH_BEACH

LYST LRBA

9.92e-0481132PS51783
DomainARM-type_fold

DOCK3 CEP104 ARFGEF2 LYST PIK3R4 LRBA STKLD1 SYMPK

1.06e-033391138IPR016024
DomainBROMODOMAIN_1

PBRM1 BRDT TAF1

1.44e-03371133PS00633
DomainVWFA

VWA8 COL6A5 INTS6 CLCA2

1.55e-03821134PS50234
DomainVWA

VWA8 COL6A5 INTS6 CLCA2

1.69e-03841134SM00327
DomainG_TR_1

GFM2 EFTUD2

2.71e-03131132PS00301
DomainHEAT

CEP104 PIK3R4 SYMPK

3.06e-03481133PF02985
DomainVWF_A

VWA8 COL6A5 INTS6 CLCA2

3.08e-03991134IPR002035
DomainC2_dom

RPGRIP1 PLCD4 PTEN C2CD3 PLCG1

3.22e-031641135IPR000008
Domain-

MYO10 PTPN14 ACBD4

3.24e-034911331.20.80.10
DomainFERM/acyl-CoA-bd_prot_3-hlx

MYO10 PTPN14 ACBD4

3.44e-03501133IPR014352
DomainEF-hand_like

PLCD4 PLCG1

3.62e-03151132PF09279
DomainPI-PLC-Y

PLCD4 PLCG1

3.62e-03151132PF00387
DomainPLCYc

PLCD4 PLCG1

3.62e-03151132SM00149
DomainPLipase_C_Pinositol-sp_Y

PLCD4 PLCG1

3.62e-03151132IPR001711
DomainPIPLC_Y_DOMAIN

PLCD4 PLCG1

3.62e-03151132PS50008
DomainPI-PLC_fam

PLCD4 PLCG1

3.62e-03151132IPR001192
DomainPLC_EF-hand-like

PLCD4 PLCG1

3.62e-03151132IPR015359
DomainPH_dom-like

MYO10 PLCD4 LYST TIAM2 PTPN14 PHLPP1 PLCG1 LRBA

4.37e-034261138IPR011993
DomainWD40

AHI1 WDR81 DYNC2I1 LYST PIK3R4 LRBA

4.93e-032591136PF00400
DomainEFTu-like_2

GFM2 EFTUD2

5.21e-03181132IPR004161
DomainPI-PLC-X

PLCD4 PLCG1

5.21e-03181132PF00388
DomainPLCXc

PLCD4 PLCG1

5.21e-03181132SM00148
DomainGTP_EFTU_D2

GFM2 EFTUD2

5.21e-03181132PF03144
DomainG_TR_2

GFM2 EFTUD2

5.21e-03181132PS51722
DomainHEAT

CEP104 PIK3R4 SYMPK

5.23e-03581133IPR000357
DomainKinase-like_dom

FLT1 STK38 WDR81 MAPKAPK5 RYK SGK2 PIK3R4 LTK STKLD1

5.65e-035421139IPR011009
DomainTF_GTP-bd_dom

GFM2 EFTUD2

5.80e-03191132IPR000795
DomainPIPLC_X_DOMAIN

PLCD4 PLCG1

5.80e-03191132PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCD4 PLCG1

5.80e-03191132IPR000909
DomainWD40

AHI1 WDR81 DYNC2I1 LYST PIK3R4 LRBA

5.81e-032681136SM00320
DomainARM-like

CEP104 ARFGEF2 PIK3R4 LRBA STKLD1 SYMPK

6.02e-032701136IPR011989
PathwayWP_GASTRIC_ACID_PRODUCTION

PGA4 PGA5 PGA3

3.61e-0511873M39726
Pubmed

The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.

PGA4 PGA5 PGA3

3.43e-08311437926498
Pubmed

Crystal structure of human pepsinogen A.

PGA4 PGA5 PGA3

3.43e-08311439561228
Pubmed

The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.

PGA4 PGA5 PGA3

3.43e-083114321455714
Pubmed

Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.

PGA4 PGA5 PGA3

3.43e-083114319800305
Pubmed

Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.

PGA4 PGA5 PGA3

3.43e-083114324170207
Pubmed

Relationships between the human pepsinogen DNA and protein polymorphisms.

PGA4 PGA5 PGA3

3.43e-08311433014868
Pubmed

The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.

PGA4 PGA5 PGA3

3.43e-08311432799289
Pubmed

CRYSTALLINE PEPSIN : I. ISOLATION AND TESTS OF PURITY.

PGA4 PGA5 PGA3

3.43e-083114319872561
Pubmed

Human pepsinogen A (PGA): an informative gene complex located at 11q13.

PGA4 PGA5 PGA3

3.43e-08311431968039
Pubmed

Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.

PGA4 PGA5 PGA3

3.43e-08311438053437
Pubmed

Family and population studies on the human pepsinogen A multigene family.

PGA4 PGA5 PGA3

3.43e-08311432566575
Pubmed

Immunoblot technique to visualise serum pepsinogen A isozymogen patterns.

PGA4 PGA5 PGA3

3.43e-08311432229438
Pubmed

Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.

PGA4 PGA5 PGA3

3.43e-083114325314140
Pubmed

Validation of the pepsinogen test method for gastric cancer screening using a follow-up study.

PGA4 PGA5 PGA3

3.43e-083114319890696
Pubmed

Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.

PGA4 PGA5 PGA3

3.43e-08311438244094
Pubmed

Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.

PGA4 PGA5 PGA3

3.43e-083114321407214
Pubmed

Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A.

PGA4 PGA5 PGA3

3.43e-08311436774973
Pubmed

Primary structure of human pepsinogen gene.

PGA4 PGA5 PGA3

3.43e-08311436300126
Pubmed

Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.

PGA4 PGA5 PGA3

3.43e-083114322304859
Pubmed

Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.

PGA4 PGA5 PGA3

3.43e-083114324004680
Pubmed

Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole.

PGA4 PGA5 PGA3

3.43e-08311438038355
Pubmed

Human pepsinogen A isozymogen patterns in serum and gastric mucosa.

PGA4 PGA5 PGA3

3.43e-08311432227273
Pubmed

Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.

PGA4 PGA5 PGA3

3.43e-083114323034090
Pubmed

A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.

PGA4 PGA5 PGA3

3.43e-083114324125879
Pubmed

Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C.

PGA4 PGA5 PGA3

3.43e-08311438751234
Pubmed

Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen A.

PGA4 PGA5 PGA3

3.43e-08311433554488
Pubmed

Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study.

PGA4 PGA5 PGA3

3.43e-083114323521833
Pubmed

Close linkage of human chromosomal pepsinogen A genes.

PGA4 PGA5 PGA3

3.43e-08311433017318
Pubmed

Serum pepsinogen test for early detection of gastric cancer in a European country.

PGA4 PGA5 PGA3

3.43e-083114321989121
Pubmed

Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.

PGA4 PGA5 PGA3

3.43e-08311439855083
Pubmed

Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.

PGA4 PGA5 PGA3

3.43e-08311439797498
Pubmed

The glomerular sieving of pepsinogen A and C in man.

PGA4 PGA5 PGA3

3.43e-08311432478370
Pubmed

Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.

PGA4 PGA5 PGA3

3.43e-08311433815274
Pubmed

Pepsinogens: physiology, pharmacology pathophysiology and exercise.

PGA4 PGA5 PGA3

3.43e-083114310675278
Pubmed

Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.

PGA4 PGA5 PGA3

3.43e-08311433780036
Pubmed

Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.

PGA4 PGA5 PGA3

3.43e-08311432901984
Pubmed

Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.

PGA4 PGA5 PGA3

3.43e-08311433839486
Pubmed

Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.

PGA4 PGA5 PGA3

3.43e-08311433467902
Pubmed

The pepsinogens of human gastric mucosa.

PGA4 PGA5 PGA3

3.43e-08311434586732
Pubmed

Genomic structure and evolution of the human pepsinogen A multigene family.

PGA4 PGA5 PGA3

3.43e-08311432892778
Pubmed

The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.

PGA4 PGA5 PGA3

3.43e-083114324383519
Pubmed

Gene structures of pepsinogens A and C.

PGA4 PGA5 PGA3

3.43e-08311431455184
Pubmed

Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.

PGA4 PGA5 PGA3

3.43e-08311432831884
Pubmed

Localization of pepsinogen (A and C) and cellular differentiation of pepsinogen-synthesizing cells in the human gastric mucosa.

PGA4 PGA5 PGA3

3.43e-08311432032552
Pubmed

Analysis of the promoter of a human pepsinogen A gene.

PGA4 PGA5 PGA3

3.43e-08311431812762
Pubmed

O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.

PGA4 PGA5 PGA3

3.43e-08311437923573
Pubmed

Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping.

PGA4 PGA5 PGA3

3.43e-08311439061458
Pubmed

Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis.

PGA4 PGA5 PGA3

3.43e-083114312588289
Pubmed

Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.

PGA4 PGA5 PGA3

3.43e-083114323897256
Pubmed

An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse.

PGA4 PGA5 PGA3

3.43e-083114311566730
Pubmed

The effect of acute and chronic protein loading on urinary pepsinogen A excretion.

PGA4 PGA5 PGA3

3.43e-08311431956484
Pubmed

Transcription regulation of human and porcine pepsinogen A.

PGA4 PGA5 PGA3

3.43e-08311438540382
Pubmed

Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study.

PGA4 PGA5 PGA3

3.43e-083114322992016
Pubmed

The role of serum pepsinogen in the detection of gastric cancer.

PGA4 PGA5 PGA3

3.43e-083114320981206
Pubmed

Gastric chief cell-specific transcription of the pepsinogen A gene.

PGA4 PGA5 PGA3

3.43e-08311438504820
Pubmed

Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry.

PGA4 PGA5 PGA3

3.43e-083114321970995
Pubmed

Serum pepsinogens in gastric cancer screening.

PGA4 PGA5 PGA3

3.43e-083114320428942
Pubmed

The relationship of Helicobacter pylori colonization, the serum pepsinogen A level, and gastric resection.

PGA4 PGA5 PGA3

3.43e-08311439525001
Pubmed

Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.

PGA4 PGA5 PGA3

3.43e-08311437886402
Pubmed

Serum pepsinogen and gastric cancer screening.

PGA4 PGA5 PGA3

3.43e-083114317379991
Pubmed

Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.

PGA4 PGA5 PGA3

3.43e-083114321547904
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DOCK3 RIN3 VWA8 MYO10 MED14 ARFGEF2 RAPGEF1 MAPKAPK5 LYST TIAM2 CDK5R1 FAT1 C2CD3 PLCG1 LTK LRBA SYMPK

1.24e-0711051141735748872
Pubmed

Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes.

PGA4 PGA5 PGA3

1.37e-074114323047493
Pubmed

Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.

PGA4 PGA5 PGA3

1.37e-074114311915945
Pubmed

Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.

PGA4 PGA5 PGA3

1.37e-07411438322031
Pubmed

Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.

PGA4 PGA5 PGA3

1.37e-074114317136346
Pubmed

Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.

PGA4 PGA5 PGA3

1.37e-074114312698190
Pubmed

Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling.

PGA4 PGA5 ATP4B PGA3

3.23e-0718114436057966
Pubmed

Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis.

PGA4 PGA5 PGA3

3.41e-075114322066020
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

FLT1 ENPP2 SMCHD1 LYST INTS6 FAT1 DPH5 CLCA2 PRCP A2ML1 TAF1

2.15e-065521141110737800
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

VWA8 ZMYND8 YY1 INTS10 SNIP1 SETDB1 INTS6 FAT1 PTPN14 PBRM1 BRDT CBY2 TAF1 LTK ILVBL

3.85e-0611161141531753913
Pubmed

Multiple roles of epithelial heparan sulfate in stomach morphogenesis.

PGA4 PGA5 ATP4B PGA3

5.30e-0635114429700203
Pubmed

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.

PGA4 PGA5 ATP4B PGA3

1.01e-0541114423676500
Pubmed

Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo.

SERHL2 SERHL

1.07e-052114211352564
Pubmed

Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.

PGA4 PGA5

1.07e-05211422714789
Pubmed

Activation of human pepsinogens.

PGA4 PGA5

1.07e-05211423197840
Pubmed

Intracellular redox status controls membrane localization of pro- and anti-migratory signaling molecules.

BCAR1 PTEN

1.07e-052114224494199
Pubmed

Enhanced response to pulmonary Streptococcus pneumoniae infection is associated with primary ciliary dyskinesia in mice lacking Pcdp1 and Spef2.

SPEF2 CFAP221

1.07e-052114224360193
Pubmed

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.

PTEN PHLPP1

1.07e-052114221840483
Pubmed

Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G.

RAPGEF1 BCAR1

1.07e-05211429748234
Pubmed

The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma.

FLT1 PLCG1

1.07e-05211429299537
Pubmed

Crystal structure of human pepsin and its complex with pepstatin.

PGA4 PGA5

1.07e-05211427663352
Pubmed

Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression.

ENPP2 PLCG1

1.07e-052114220231358
Pubmed

Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.

PGA4 PGA5

1.07e-05211422415509
Pubmed

Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers.

FLT1 PLCG1

1.07e-052114211312102
Pubmed

YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization.

PTEN YY1

1.07e-052114232334006
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

IARS1 SMCHD1 ZMYND8 EFTUD2 SETDB1 PBRM1 TAF1 SYMPK

1.45e-05332114832786267
Pubmed

An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.

SMCHD1 SETDB1 PBRM1

2.70e-0518114324025402
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

A2M ABCA1 SMCHD1 ZMYND8 MED14 WDR81 EFTUD2 PBRM1

2.74e-05363114814691545
Pubmed

IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling.

PTEN MAPKAPK5

3.19e-053114222279049
Pubmed

PTEN and PHLPP crosstalk in cancer cells and in TGFβ-activated stem cells.

PTEN PHLPP1

3.19e-053114232294598
Pubmed

Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis.

MMP1 ALOX15

3.19e-053114219296842
Pubmed

Genetic interaction between central pair apparatus genes CFAP221, CFAP54, and SPEF2 in mouse models of primary ciliary dyskinesia.

SPEF2 CFAP221

3.19e-053114232704025
Pubmed

PTEN inhibits replicative senescence-induced MMP-1 expression by regulating NOX4-mediated ROS in human dermal fibroblasts.

PTEN MMP1

3.19e-053114228557373
Pubmed

Acacetin inhibits expression of matrix metalloproteinases via a MAPK-dependent mechanism in fibroblast-like synoviocytes.

GAPDH MMP1

3.19e-053114225856795
Pubmed

Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.

CLCA2 LY75

3.19e-053114225557950
Pubmed

Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma.

MYO10 PTEN

3.19e-053114233299973
Pubmed

alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis.

A2M A2ML1

3.19e-053114210487856
Pubmed

Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.

BCAR1 PTEN

3.19e-05311429927060
Pubmed

PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma.

PTEN YY1

3.19e-053114219483472
InteractionUCN3 interactions

FAT4 VWA8 CD109 FAT1

7.64e-06231134int:UCN3
Cytoband10q23.3

PTEN TNKS2

1.27e-047114210q23.3
Cytoband3q22.1

TOPBP1 COL6A5 PIK3R4

1.60e-044211433q22.1
CytobandEnsembl 112 genes in cytogenetic band chr3q22

TOPBP1 COL6A5 RYK PIK3R4

3.71e-041351144chr3q22
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

A2M CD109 A2ML1

4.79e-0697131234
GeneFamilyWD repeat domain containing|BEACH domain containing

WDR81 LYST LRBA

4.79e-0697131230
GeneFamilyReceptor Tyrosine Kinases|CD molecules

FLT1 RYK LTK

5.17e-0440713321
GeneFamilyWD repeat domain containing

AHI1 WDR81 DYNC2I1 LYST PIK3R4 LRBA

5.70e-04262716362
GeneFamilyIntegrator complex

INTS10 INTS6

1.54e-03157121366
GeneFamilyCadherin related

FAT4 FAT1

1.99e-031771224
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCD4 PLCG1

2.49e-0319712832
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

MYO10 SMCHD1 MARCHF6 ZMYND8 TOPBP1 SOCS6 PTEN YY1 RYK PIK3R4 SETDB1 FAT1 C2CD3 PHLPP1

1.94e-0585611314M4500
CoexpressionRIGGI_EWING_SARCOMA_PROGENITOR_UP

A2M FAT4 NPY1R MYO10 PCGF5 CLDN1 CLCA2 CSRNP3 FRZB MMP1

2.02e-0543711310M15981
CoexpressionGSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_UP

PUS3 VWA8 ENPP2 INTS6 PRCP LRBA DOP1A

2.64e-052001137M8042
CoexpressionGSE27786_CD8_TCELL_VS_NKTCELL_UP

ZFAT SMCHD1 STK38 BCAR1 RYK DPH5 PLCG1

2.64e-052001137M4839
CoexpressionGSE40666_NAIVE_VS_EFFECTOR_CD8_TCELL_WITH_IFNA_STIM_90MIN_UP

MYO10 STK38 TRMO TIAM2 ACBD4 PDE5A PDCD10

2.64e-052001137M9208
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_top-relative-expression-ranked_1000

FAT4 ABCA1 SGMS2 IQGAP2 ENPP2 CD109 MED14 ARFGEF2 PTEN TIAM2 CDK5R1 C2CD3 CSRNP3 FRZB TNKS2 LY75

2.79e-0676911216gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_1000

FAT4 ABCA1 IQGAP2 MYO10 MED14 ARFGEF2 SOCS6 RUFY2 SETDB1 CDK5R1 C2CD3 CLCA2 CSRNP3 FRZB PDE5A TNKS2

5.06e-0680611216DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_1000
CoexpressionAtlasDevelopingKidney_e15.5_Medullary collecting duct_emap-28063_k-means-cluster#4_top-relative-expression-ranked_1000

AHI1 IQGAP2 VWA8 MYO10 MED14 ARFGEF2 RUFY2 C2CD3 TNKS2

1.02e-052611129gudmap_developingKidney_e15.5_Medullary collecting duct_1000_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#5_top-relative-expression-ranked_500

ABCA1 IQGAP2 MYO10 ARFGEF2 CDK5R1 C2CD3 TNKS2

1.42e-051491127gudmap_developingLowerUrinaryTract_e14.5_ urethra_500_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000

ABCA1 IQGAP2 MED14 ARFGEF2 PTEN CDK5R1 C2CD3 TNKS2

1.53e-052091128gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000

ABCA1 IQGAP2 MYO10 MED14 ARFGEF2 SOCS6 RUFY2 SETDB1 C2CD3 TNKS2

2.61e-0536911210DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_500

FAT4 ABCA1 IQGAP2 MYO10 ARFGEF2 CDK5R1 C2CD3 CLCA2 PDE5A TNKS2

5.96e-0540711210gudmap_developingLowerUrinaryTract_e14.5_ urethra_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_500

FAT4 ABCA1 IQGAP2 ARFGEF2 SETDB1 CLCA2 CSRNP3 FRZB PDE5A TNKS2

6.09e-0540811210DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_2500_k-means-cluster#3

ABCA1 AHI1 MYO10 MARCHF6 MED14 WDR81 CEMIP2 FAT1 C2CD3 CSRNP3 PHLPP1 DHX32 TTLL1 ELK4 MGAT5B

7.06e-0589311215Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_2500_K3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000

FAT4 ABCA1 AHI1 IQGAP2 VWA8 MYO10 ARFGEF2 SETDB1 CDK5R1 C2CD3 CLCA2 FRZB PDE5A TNKS2

8.81e-0580611214gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlasDevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_k-means-cluster#3_top-relative-expression-ranked_500

AHI1 VWA8 MYO10 MED14 ARFGEF2 C2CD3 TNKS2

9.60e-052011127gudmap_developingKidney_e15.5_500_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000

FAT4 ABCA1 SGMS2 AHI1 IQGAP2 ARFGEF2 SOCS6 PTEN RYR2 RUFY2 SETDB1 CLCA2 CSRNP3 TNKS2

1.03e-0481811214DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500

ABCA1 IQGAP2 MYO10 RYR2 C2CD3 PDE5A TNKS2

1.22e-042091127gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#5_top-relative-expression-ranked_1000

AHI1 MYO10 MED14 ARFGEF2 C2CD3 TNKS2

1.25e-041461126gudmap_developingKidney_e15.5_Cap mesenchyme_1000_k5
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#4_top-relative-expression-ranked_1000

AHI1 IQGAP2 VWA8 MYO10 MED14 ARFGEF2 RUFY2 C2CD3 TNKS2

1.69e-043751129gudmap_developingKidney_e15.5_cortic collect duct_1000_k4
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#1_top-relative-expression-ranked_200

AHI1 ARFGEF2 TNKS2

2.04e-04221123gudmap_developingKidney_e15.5_Cap mesenchyme_200_k1
CoexpressionAtlasDevelopingKidney_e15.5_cortic collect duct_emap-28132_k-means-cluster#4_top-relative-expression-ranked_500

AHI1 VWA8 MED14 ARFGEF2 C2CD3 TNKS2

2.28e-041631126gudmap_developingKidney_e15.5_cortic collect duct_500_k4
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_top-relative-expression-ranked_1000

AHI1 PUS3 MYO10 TOM1L1 MED14 ARFGEF2 RYK INTS10 CDK5R1 C2CD3 FRZB TNKS2 LY75

2.36e-0477911213gudmap_developingKidney_e15.5_Cap mesenchyme_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_1000

ABCA1 AHI1 IQGAP2 MYO10 ARFGEF2 SETDB1 C2CD3 TNKS2

2.52e-043121128gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k2
CoexpressionAtlasDevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_500

AHI1 VWA8 MYO10 MED14 ARFGEF2 SGK2 C2CD3 PTPN14 TNKS2

2.82e-044021129gudmap_developingKidney_e15.5_anlage of loop of Henle_500
CoexpressionAtlasDevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_1000

AHI1 IQGAP2 VWA8 MYO10 ENPP2 MED14 ARFGEF2 RYK SGK2 RUFY2 C2CD3 PTPN14 TNKS2

2.88e-0479511213gudmap_developingKidney_e15.5_anlage of loop of Henle_1000
CoexpressionAtlasalpha beta T cells, T.4Nve.PP, TCR+ CD4+ CD44low CD62Lhigh, Peyer's Patch, avg-2

MYO10 STK38 DPH5 ELK4 PLCG1 TNKS2 LY75 DOP1A

3.45e-043271128GSM538380_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#2_top-relative-expression-ranked_1000

ABCA1 AHI1 IQGAP2 SOCS6 RYR2 RUFY2 SETDB1 TNKS2

3.66e-043301128DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k2_1000
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#2_top-relative-expression-ranked_200

CYP1B1 FAT4 IQGAP2 CLDN1 CSRNP3

3.76e-041161125gudmap_developingKidney_e15.5_Peripheral blastema_200_k2
CoexpressionAtlasdev gonad_e13.5_M_DevVasTestis_Flk_top-relative-expression-ranked_200

FLT1 ABCA1 IQGAP2 CLCA2 AEBP1 PRCP

3.77e-041791126gudmap_dev gonad_e13.5_M_gudmap_devVasTestis_Flk_200
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000

FAT4 ABCA1 AHI1 IQGAP2 MYO10 MED14 RYR2 CDK5R1 C2CD3 CLCA2 FRZB PDE5A TNKS2

3.78e-0481811213gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Central Eminence_top-relative-expression-ranked_1000_k-means-cluster#3

ABCA1 MARCHF6 WDR81 CEMIP2 CSRNP3 PHLPP1 TTLL1 MGAT5B

4.38e-043391128Facebase_RNAseq_e10.5_Neural Epithelium Overlying Central Eminence_1000_K3
CoexpressionAtlasDevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_1000

AHI1 IQGAP2 MYO10 MED14 PTEN RUFY2 C2CD3 TNKS2

4.38e-043391128gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k5
CoexpressionAtlasdev gonad_e13.5_F_MeioticGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_1000

DOCK3 LYST INTS6 HACE1 LRBA DOP1A

4.76e-041871126gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_k3_1000
CoexpressionAtlasDevelopingKidney_e15.5_S-shaped body_emap-27855_k-means-cluster#3_top-relative-expression-ranked_500

AHI1 ARFGEF2 C2CD3 TNKS2

6.35e-04741124gudmap_developingKidney_e15.5_S-shaped body_500_k3
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D175|Adult / Lineage, Cell type, age group and donor

A2M MYO10 ENPP2 COL6A5 RYR2 AEBP1 PDE5A

5.41e-071871147e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FAT4 FLT1 ENPP2 CD109 RAPGEF1 RYR2

6.93e-071941147a429d22c8c9d0fd3bfa9f877a6364cecad68db30
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M CYP1B1 FLT1 CD109 LYST PTPN14 PRCP

7.17e-07195114781a98ebb0d43f416f9a8bba580531dc0cfea8f74
ToppCellParenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

A2M FAT4 COL6A5 RYR2 AEBP1 FRZB PDE5A

8.50e-072001147aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

A2M FAT4 COL6A5 RYR2 AEBP1 FRZB PDE5A

8.50e-072001147a510deaada669e690329183e18df02870bd204b3
ToppCellLung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

A2M FAT4 COL6A5 RYR2 AEBP1 FRZB PDE5A

8.50e-072001147dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 MYO10 SMCHD1 YY1 LYST ELK4

6.60e-06178114601dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

A2M ZFAT EFTUD2 PLCG1 PDCD10 SYMPK

7.03e-06180114681d60f0fa9e3b5bfcec85139a0a49e9130145f0e
ToppCell3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M CYP1B1 FLT1 ENPP2 CD109 PTPN14

8.22e-061851146fa94c4a1660967f211ba095606cd0aa37d38e17a
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M MYO10 PTEN RYR2 FAT1 PDE5A

8.48e-061861146888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCelldroplet-Heart-nan-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 MYO10 LYST CEMIP2 PTPN14 ELK4

8.48e-0618611460ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell3'-Adult-Appendix-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M CYP1B1 FLT1 ENPP2 CD109 PTPN14

8.74e-06187114637d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCell3'-Adult-Appendix-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M CYP1B1 FLT1 ENPP2 CD109 PTPN14

8.74e-061871146ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCellControl-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

FLT1 MYO10 CD109 RAPGEF1 CEMIP2 FAT1

9.57e-0619011467f3f419fffe02934b6f27b697f7a6401072491ed
ToppCellCOVID-19-lung-Vein_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FAT4 FLT1 CD109 LYST CEMIP2 PRCP

9.57e-0619011461caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|kidney / Disease (COVID-19 only), tissue and cell type

A2M FAT4 FLT1 ENPP2 CD109 RAPGEF1

9.57e-0619011461519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

A2M SMCHD1 ARFGEF2 LYST CEMIP2 LRBA

9.86e-0619111469454f642c3621370fa23640b631301346b300950
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FLT1 RIN3 ENPP2 CD109 RAPGEF1

1.02e-0519211463259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT4 FLT1 ENPP2 SPEF2 CD109 PRCP

1.05e-051931146e09387af84d2a0a526e54d4793e6e06c6739db53
ToppCellLPS-antiTNF-Endothelial-Endothelial-Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT4 FLT1 ENPP2 SPEF2 CD109 PRCP

1.05e-0519311466e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT4 FLT1 ENPP2 SPEF2 CD109 PRCP

1.05e-051931146af5108260783e69a7d67896c5bf64f862525926d
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT4 FLT1 SPEF2 CD109 CEMIP2 LTK

1.08e-05194114668004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FLT1 RIN3 ENPP2 CD109 RAPGEF1

1.11e-0519511466bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCellfacs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AHI1 ENPP2 BCAR1 NIPAL3 FRZB PDE5A

1.11e-051951146bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCellBasal_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

CD109 CLDN1 FAT1 PTPN14 CLCA2 MMP1

1.14e-0519611463b66f3a79b3f2ebacb4ad646f179e505ab38d6f0
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

CYP1B1 ABCA1 MYO10 DYNC2I1 COL6A5 RYR2

1.18e-051971146fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M FAT4 RYR2 INTS6 AEBP1 PDE5A

1.18e-05197114694a9603cbd3516fbcce871909693b88f20d41713
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M CYP1B1 FLT1 CD109 LYST PRCP

1.18e-0519711460542badae77d2f606c13cfaf361319495c354351
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M COL6A5 RYR2 AEBP1 FRZB PDE5A

1.18e-05197114613896ec65ccda0b928c91d41112dc01b480036b7
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M CYP1B1 FLT1 CD109 LYST PRCP

1.18e-051971146a6a64581699cfcb9607b288976fa3b09648725b7
ToppCellnormal_Lung-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

A2M MYO10 ENPP2 COL6A5 FRZB PDE5A

1.21e-051981146e0e47cf65774191981840b22905b2094b95abe0f
ToppCellcellseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

A2M CYP1B1 FLT1 CD109 LYST PRCP

1.25e-05199114668412bc39639edc4045437d62548f7101b9f1989
ToppCellBronchus_Control_(B.)-Stromal-TX-Smooth_muscle-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

A2M NPY1R RYR2 AEBP1 FRZB PDE5A

1.25e-0519911462c5ad62919c64ea0242e0984bb9932d2d975f4e3
ToppCellcellseq-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

A2M COL6A5 RYR2 AEBP1 FRZB PDE5A

1.25e-05199114666a79732caf2f04c09b4d9832377aa01ca477677
ToppCellBronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

A2M CYP1B1 FAT4 FLT1 ENPP2 PTPN14

1.25e-0519911466a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

DOCK3 AHI1 CLDN1 RYR2 FAT1 PDE5A

1.28e-052001146c5e051f1aac8dda376c342a9932785a23450e073
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FAT4 FLT1 ENPP2 SPEF2 CD109 PRCP

1.28e-052001146a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellmedial-Endothelial-Vein-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M CYP1B1 FLT1 CEMIP2 PRCP MMP1

1.28e-0520011463f689029f5bc7db0af50a405f1e252aeec529077
ToppCellBronchial-10x5prime-Stromal-Fibroblastic-Fibro_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

A2M COL6A5 RYR2 AEBP1 FRZB PDE5A

1.28e-052001146cb31cfcfa8e6d6cc610c4c22e97bc009dd8a9e7c
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

FAT4 FLT1 ENPP2 SPEF2 CD109 PRCP

1.28e-052001146b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

CYP1B1 ABCA1 MYO10 COL6A5 RYR2 CEMIP2

1.28e-052001146a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellmedial-Endothelial-Vein|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M CYP1B1 FLT1 CEMIP2 PRCP MMP1

1.28e-0520011461163e5f6dfb304c94bf8885629350454f4b6bee8
ToppCellmedial-2-Endothelial-Vein|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M CYP1B1 FLT1 CEMIP2 PRCP MMP1

1.28e-05200114649da4e3ff10262a492c2cf566a7f2e35e418bfda
ToppCell3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

SMCHD1 CEMIP2 PLCG1 LRBA FOXI1

2.55e-051351145ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCellNS-critical-d_0-4-Myeloid-pDC|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ZFAT AGPAT5 ACBD4 AEBP1 CBY2

3.47e-0514411450fde5cd82df9b90aefde19275cff6c2ec3c9d5cb
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

AHI1 ZFAT OVOS2 AEBP1 LTK

5.09e-05156114519472ef1642c2ad333aa3ce3675a25c6ab1d4556
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L2/3_IT-L2/3_IT_VISp_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DUSP18 ENPP2 TOM1L1 TIAM2 PTPN14

5.09e-0515611452cd007b423c2395c5ce331902e7f27c805755eb3
ToppCell356C-Fibroblasts-Fibroblast-G-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

A2M MYO10 PLCD4 COL6A5 RYR2

5.74e-0516011450293b244c063a62819690bf22bbc2681f8d15252
ToppCell356C-Fibroblasts-Fibroblast-G|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

A2M MYO10 PLCD4 COL6A5 RYR2

5.74e-0516011453eaae86fa08f7651021316f8e5811bf48055591e
ToppCellfacs-Kidney-nan-24m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBPL2 CYP1B1 FAT1 AEBP1 MGAT5B

6.64e-0516511454cdd80580d5638fd649280ba3893251c2f898f3f
ToppCellfacs-Kidney-nan-24m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBPL2 CYP1B1 FAT1 AEBP1 MGAT5B

6.64e-051651145c746bb22ef52d7f7fa6ee9c37ae6bbe0ccce718e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FAT4 FLT1 ENPP2 RYR2

6.83e-051661145ec719368295133da2f7ff587c5329ed6db1dd56d
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SERHL2 CD109 COL6A5 RYR2 UBA7

7.23e-051681145c66a61d3ec711796313a2c6d2dc39aedbfc20afd
ToppCell368C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

SERHL2 CD109 COL6A5 RYR2 UBA7

7.23e-05168114583b4f817d95daa15ae60668e789f97d8a3b2e6dd
ToppCelldroplet-Marrow-nan-3m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZFAT RAPGEF1 RUFY2 HACE1 STKLD1

7.43e-0516911455f5bec13208f4c3b6eacbba180c8a6402743b76e
ToppCell367C-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

ZFAT AGPAT5 AEBP1 LTK STKLD1

7.64e-051701145fbb7019c6fba87326702b51f6819ea1af5f3a9b7
ToppCelldroplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP1B1 CLCA2 AEBP1 CFAP221 ALOX15

8.53e-051741145a0ccda8fd6f55251cdeff24cf66e72e4a31d2104
ToppCellsevere_influenza-pDC|severe_influenza / disease group, cell group and cell class (v2)

SERHL2 ZFAT AEBP1 LTK ALOX15

8.53e-051741145d8d2ded5812ed3b3db4109585714a6513c13326a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CYP1B1 NPY1R AEBP1 FRZB

8.53e-05174114595464817adef5ad2038bbf542f315756b7ad862e
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AHI1 TOM1L1 WDR81 INTS6 ILVBL

8.76e-051751145bb898796662b97f7459b7dda7cecf6a9bde8b055
ToppCellT_cells-Tph_and_Tfh|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

FLT1 AHI1 CD109 LYST PTPN14

9.00e-05176114556c055488e34605d32562571a2fee621b47c9441
ToppCellCF-Lymphoid-pDC|CF / Disease state, Lineage and Cell class

ZFAT AGPAT5 ENPP2 AEBP1 LTK

9.00e-051761145dd1e529a9e413bcaab43584afbe059e1464ffb53
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPEF2 COL6A5 CFAP221 PDE5A FOXI1

9.24e-051771145e8bb4f8ecd5e283efec966b9fc2040a6152d5551
ToppCell356C-Fibroblasts-Fibroblast-G|356C / Donor, Lineage, Cell class and subclass (all cells)

A2M PLCD4 COL6A5 RYR2 FRZB

9.24e-0517711458220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell356C-Fibroblasts-Fibroblast-G-|356C / Donor, Lineage, Cell class and subclass (all cells)

A2M PLCD4 COL6A5 RYR2 FRZB

9.24e-0517711457617270f49cd6b7ba66db72d20560cee985012b2
ToppCellmyeloid-Dendritic_cell-Plasmacytoid_dendritic_cell|myeloid / Lineage, cell class and subclass

AHI1 ZFAT ENPP2 AEBP1 LTK

9.49e-051781145f75591988bbbeba073b66329a3437cb9b02f7648
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

FLT1 ZMYND8 ARFGEF2 AEBP1 LY75

9.49e-051781145edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M NPY1R PTEN PGA5 AEBP1

9.49e-051781145d4ecb84e9b1f4ec49c519321156aa10f9bd34cce
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CYP1B1 NPY1R AEBP1 FRZB

9.75e-051791145b70509288aaf4457afd350f6c45784521337ce0d
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 FLT1 MYO10 RYK CEMIP2

1.03e-0418111454df7972f88117108698efd06b124b232f8588981
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

A2M MYO10 COL6A5 RYR2 PDE5A

1.03e-0418111459ede19228ba5c0668a9c06c915510b95585216ef
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAT4 FLT1 MYO10 RYK CEMIP2

1.03e-041811145cbb530566893281289026bfd93adf721decd4ca3
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M CYP1B1 FLT1 LYST PRCP

1.05e-041821145d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCelldroplet-Marrow-nan-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IQGAP2 SMCHD1 TOPBP1 SOCS6 LYST

1.05e-041821145bc8d621be57f76d718d9b0f11e023b0f4dcb668d
ToppCell390C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|390C / Donor, Lineage, Cell class and subclass (all cells)

A2M CYP1B1 GAPDH AEBP1 MMP1

1.08e-04183114528e1fc6498aaf8f42c4d6d4fa54ffff4c546d0d1
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

AHI1 ZFAT ENPP2 AEBP1 LTK

1.08e-0418311453b123571e10c132227aff65648b4b3c6acb4bd00
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

AHI1 ZFAT ENPP2 AEBP1 LTK

1.08e-041831145df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCell390C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|390C / Donor, Lineage, Cell class and subclass (all cells)

A2M CYP1B1 GAPDH AEBP1 MMP1

1.08e-041831145667d9107af17fd076ceff6b2cbcb78f892fd62d2
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

CYP1B1 FAT4 ABCA1 PTEN CSRNP3

1.11e-04184114567164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ABCA1 GAPDH CD109 RAPGEF1 PTEN

1.11e-041841145a902109b04a94770f5f6db5ddc372049f2921d38
ToppCell(7)_MNP-(7)_DC_plasmacytoid|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)

SERHL2 AHI1 ZFAT AEBP1 LTK

1.14e-0418511459f67f652488e17075a372e2a2e1100f6d0af6d7d
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D231|Adult / Lineage, Cell type, age group and donor

FLT1 CD109 CEMIP2 LTK MGAT5B

1.14e-04185114507f9f38f0739d7c830641723a38385550ac1ac92
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CYP1B1 NPY1R AEBP1 FRZB

1.14e-041851145e1fbec55b71f604189eb2431768fadbaa0453a83
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M CYP1B1 NPY1R AEBP1 FRZB

1.14e-0418511459d933cd5ebc8368fd37aa83113d2dfa6938ff72d
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c5-WDR74|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CYP1B1 FLT1 SGMS2 CD109 SOCS6

1.14e-04185114568edb1bb03ed221d49e583123ca4de14252d7bc5
ToppCell343B-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

A2M FLT1 CD109 CEMIP2 LTK

1.17e-041861145dae6a98963c78bf7518ebab8dc02f173c3b0f7f7
ToppCellControl-Endothelial-Endothelial-Vein|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FLT1 RIN3 SPEF2 LYST PRCP

1.17e-04186114592092f11ecce22c14f244e42c499af0822977e6f
ToppCell343B-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

A2M FLT1 CD109 CEMIP2 LTK

1.17e-041861145080e56113b89138277a2bd2eabddfa6cd1a18b61
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

A2M FAT4 FLT1 ENPP2 RAPGEF1

1.20e-04187114540ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellhuman_hepatoblastoma-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

ABCA1 IQGAP2 TOM1L1 LYST LRBA

1.20e-041871145f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M CYP1B1 FLT1 PRCP MGAT5B

1.20e-041871145d6765854154557794815514c0aa355bc74b8523e
ToppCellCOVID-19_Severe-pDC-|COVID-19_Severe / Disease condition and Cell class

AHI1 ZFAT ENPP2 AEBP1 LTK

1.23e-0418811459fd1116e31a05554850b8ed3c005ea660dfbd51c
ToppCelldroplet-Lung-nan-18m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPY1R CD109 RYR2 FAT1 PDE5A

1.23e-04188114561f010c165826b434ca3d27553d4c9e13d2c0c51
ToppCelldroplet-Lung-nan-18m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPY1R CD109 RYR2 FAT1 PDE5A

1.23e-0418811457553ef7de3575af4cf34704b405b551c1af8eb83
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic_-_developing-thymocyte|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

AGPAT5 ENPP2 ZMYND8 CLDN1 PLCG1

1.23e-041881145bcfc426b60d8e5a23a2360bfb68b32868fec9fbf
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DOCK3 CLDN1 RYR2 AEBP1 PDE5A

1.23e-041881145293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCellCOVID-19_Mild-pDC|COVID-19_Mild / Disease condition and Cell class

AHI1 ZFAT ENPP2 AEBP1 LTK

1.23e-04188114562d33d2990d4a2d32bd0863147e47f656df1966e
ToppCellCOVID-19_Mild-pDC-|COVID-19_Mild / Disease condition and Cell class

AHI1 ZFAT ENPP2 AEBP1 LTK

1.23e-041881145a75c2cf2f8dae343c13aaa66b637658b935ed10a
ToppCellCOVID-19_Severe-pDC|COVID-19_Severe / Disease condition and Cell class

AHI1 ZFAT ENPP2 AEBP1 LTK

1.23e-041881145475008f45673b42b75ef231c2df91f8b9adc9201
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M NPY1R PTEN AEBP1 FRZB

1.26e-04189114571397e993a77d70b2eeede240bdfc7660b558987
DrugGlimepiride [93479-97-1]; Up 200; 8.2uM; MCF7; HT_HG-U133A

ABCA1 AHI1 ENPP2 SMCHD1 SOCS6 SGK2 PLCG1 DOP1A FOXI1 SYMPK

6.42e-08199114104973_UP
Druggenistein

CYP1B1 FLT1 IQGAP2 GAPDH ENPP2 TOM1L1 MED14 PLCD4 BCAR1 PTEN RYK CLDN1 RYR2 PIK3R4 CLCA2 IL22 PLCG1 MMP1 LRBA

2.75e-06111711419CID005280961
Drug0198306-0000 [212631-61-3]; Up 200; 10uM; PC3; HT_HG-U133A

RIN3 AHI1 MED14 TRMO LYST SGK2 ELK4 SYMPK

6.85e-0619711487069_UP
DrugOndansetron Hydrochloride [103639-04-9]; Down 200; 12.2uM; PC3; HT_HG-U133A

SERHL2 CYP1B1 RIN3 SOCS6 SETDB1 CDK5R1 CSRNP3 SYMPK

6.85e-0619711485796_DN
DrugAminohippuric acid [61-78-9]; Down 200; 20.6uM; PC3; HT_HG-U133A

ABCA1 AHI1 VWA8 TRMO CEMIP2 CDK5R1 PHLPP1 TNKS2

7.11e-0619811486294_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

NPY1R VWA8 ZMYND8 SOCS6 SETDB1 ELK4 ILVBL

2.90e-0517511476736_DN
DrugPCA 4248

BCAR1 MMP1 ALOX15

3.37e-05131143CID000004698
Drugaspirin, USP; Down 200; 100uM; HL60; HT_HG-U133A

CYP1B1 RIN3 AHI1 SOCS6 YY1 LYST PLCG1

5.23e-0519211476164_DN
DrugMetampicillin sodium salt [6489-61-8]; Up 200; 10.4uM; PC3; HT_HG-U133A

FAT4 TRMO SOCS6 RYK PTPN14 ELK4 DOP1A

5.23e-0519211472123_UP
Drugphthalazine

FLT1 LYST PDE5A

5.32e-05151143CID000009207
DrugAsiaticoside [16830-15-2]; Down 200; 4.2uM; MCF7; HT_HG-U133A

CEP104 ZMYND8 RYR2 ELK4 TAF1 TNKS2 SYMPK

5.77e-0519511473504_DN
DrugDiphemanil methylsulfate [62-97-5]; Up 200; 10.2uM; PC3; HT_HG-U133A

SOCS6 RYR2 UBA7 PBRM1 FRZB PDE5A PLCG1

5.95e-0519611474591_UP
DrugDrofenine hydrochloride [548-66-3]; Up 200; 11.4uM; PC3; HT_HG-U133A

SERHL2 FAT4 VWA8 TRMO YY1 LYST CLDN1

5.95e-0519611477129_UP
DrugAmphotericin B [1397-89-3]; Down 200; 4.4uM; MCF7; HT_HG-U133A

AHI1 LYST RYK RYR2 PHLPP1 TTLL1 SYMPK

5.95e-0519611475404_DN
DrugFluocinonide [356-12-7]; Down 200; 8uM; MCF7; HT_HG-U133A

A2M RIN3 CDK5R1 ACBD4 ELK4 TNKS2 SYMPK

6.15e-0519711473933_DN
DrugLomefloxacin hydrochloride [98079-52-8]; Down 200; 10.4uM; PC3; HT_HG-U133A

AHI1 VWA8 YY1 SGK2 CSRNP3 IL22 SYMPK

6.15e-0519711473723_DN
DrugGabexate mesilate [56974-61-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A

CYP1B1 NPY1R YY1 RYK CLDN1 IL22 ELK4

6.35e-0519811474804_UP
DrugKetotifen fumarate [34580-14-8]; Up 200; 9.4uM; PC3; HT_HG-U133A

ABCA1 AHI1 TRMO YY1 RYR2 SETDB1 ELK4

6.55e-0519911475842_UP
DrugTerbutaline hemisulfate [23031-32-5]; Up 200; 7.2uM; MCF7; HT_HG-U133A

RIN3 MED14 ARFGEF2 UBA7 TTLL1 ELK4 FOXI1

6.55e-0519911476240_UP
DrugTrimethylcolchicinic acid [3482-37-9]; Down 200; 11.6uM; MCF7; HT_HG-U133A

CEP104 NPY1R ZMYND8 MED14 PLCG1 TNKS2 SYMPK

6.55e-0519911472802_DN
DrugCefuroxime sodium salt [56238-63-2]; Down 200; 9uM; PC3; HT_HG-U133A

SOCS6 RYR2 SETDB1 CDK5R1 CSRNP3 PLCG1 SYMPK

6.55e-0519911475787_DN
DrugN6,2-O-dibutyryladenosine 3,5-cyclic monophosphate sodium salt; Down 200; 2uM; MCF7; HT_HG-U133A_EA

AHI1 VWA8 MED14 ARFGEF2 SETDB1 ELK4 DOP1A

6.55e-051991147959_DN
DiseaseMalignant neoplasm of breast

CYP1B1 FLT1 CD109 MED14 ARFGEF2 BCAR1 PTEN CLDN1 PIK3R4 PTPN14 PBRM1 CLCA2 DHX32 MMP1 LRBA DOP1A

2.39e-06107411016C0006142
Diseaseobstructive lung disease (is_implicated_in)

A2M MMP1

1.38e-0521102DOID:2320 (is_implicated_in)
Diseasediabetic retinopathy (biomarker_via_orthology)

FLT1 GAPDH PTEN CLDN1

2.42e-05451104DOID:8947 (biomarker_via_orthology)
Diseasecerebral cavernous malformation (is_marker_for)

FLT1 PTEN

4.12e-0531102DOID:0060669 (is_marker_for)
DiseaseHeterotopia, Periventricular, Autosomal Recessive

FAT4 ARFGEF2

4.12e-0531102C1842563
DiseaseJOUBERT SYNDROME 17

CEP104 AHI1

1.37e-0451102C3553264
Diseaselung non-small cell carcinoma (is_implicated_in)

PTEN FAT1 PBRM1 FRZB PLCG1

1.78e-041391105DOID:3908 (is_implicated_in)
Diseasebrain disease (implicated_via_orthology)

PTEN TIAM2

2.05e-0461102DOID:936 (implicated_via_orthology)
Diseaseliver cirrhosis (biomarker_via_orthology)

FLT1 CLDN1 MMP1

2.77e-04341103DOID:5082 (biomarker_via_orthology)
Diseasenicotine withdrawal symptom count

SGMS2 SMCHD1 SERHL

3.02e-04351103EFO_0009263
DiseaseHepatocellular Adenoma

A2M PTEN

4.87e-0491102C0206669
DiseaseSpastic Paraplegia

LYST HACE1

4.87e-0491102C0037772
DiseaseColorectal Neoplasms

CYP1B1 ABCA1 GAPDH CD109 FAT1 MMP1

6.14e-042771106C0009404
Diseasehepatocellular carcinoma (biomarker_via_orthology)

A2M ABCA1 PTEN CLDN1

7.27e-041081104DOID:684 (biomarker_via_orthology)
DiseaseDuctal Carcinoma

BCAR1 PTEN

7.41e-04111102C1176475
Diseasecysteine-glutathione disulfide measurement

IARS1 SERHL

7.41e-04111102EFO_0021001
DiseaseLong QT Syndrome

PTEN RYR2

7.41e-04111102C0023976
DiseasePolydactyly

AHI1 DYNC2I1 PTEN C2CD3

9.81e-041171104C0152427
Diseasemembranous glomerulonephritis (biomarker_via_orthology)

A2M ABCA1

1.22e-03141102DOID:10976 (biomarker_via_orthology)
DiseaseSaldino-Noonan Syndrome

DYNC2I1 C2CD3

1.22e-03141102C0036069
DiseaseNeoplasm Metastasis

FLT1 ENPP2 PTEN PDE5A MMP1

1.34e-032171105C0027627
Diseaseinfant head circumference

ARFGEF2 PLCG1

1.40e-03151102EFO_0004577
DiseaseAtherosclerosis

ABCA1 MMP1 ALOX15

1.41e-03591103C0004153
DiseaseAtherogenesis

ABCA1 MMP1 ALOX15

1.41e-03591103C1563937
DiseaseAlzheimer's disease (is_implicated_in)

A2M ABCA1 GAPDH CDK5R1

1.53e-031321104DOID:10652 (is_implicated_in)
Diseaseproliferative diabetic retinopathy (is_marker_for)

FLT1 ENPP2

1.60e-03161102DOID:13207 (is_marker_for)
Diseasemyocardial infarction (implicated_via_orthology)

CYP1B1 PDE5A MMP1

1.94e-03661103DOID:5844 (implicated_via_orthology)
DiseaseHemangiosarcoma

FLT1 PLCG1

2.03e-03181102C0018923
Diseasebasophil count, eosinophil count

DOCK3 RIN3 SPEF2 PTEN ALOX15

2.13e-032411105EFO_0004842, EFO_0005090
Diseaseprimary ciliary dyskinesia (implicated_via_orthology)

SPEF2 TTLL1

2.26e-03191102DOID:9562 (implicated_via_orthology)
Diseaseemphysema pattern measurement

RIN3 VWA8

2.26e-03191102EFO_0005850
Diseaseintrahepatic cholangiocarcinoma (is_marker_for)

PTEN PBRM1

2.26e-03191102DOID:4928 (is_marker_for)
Diseasemelanoma

CYP1B1 FAT4 FLT1 PTEN SETDB1

2.41e-032481105C0025202
Diseasesphingomyelin 16:0 measurement

ABCA1 SPEF2

2.50e-03201102EFO_0010391
Diseaseasthma, endometriosis

PTEN EFTUD2 SYMPK

2.70e-03741103EFO_0001065, MONDO_0004979
DiseaseJoubert syndrome 1

CEP104 AHI1

2.76e-03211102C4551568
Diseasebone density, lean body mass

RIN3 CSRNP3

2.76e-03211102EFO_0003923, EFO_0004995
Diseaselevel of Phosphatidylcholine (18:1_20:4) in blood serum

ABCA1 PGA5

2.76e-03211102OBA_2045104
DiseaseLEOPARD Syndrome

PTEN A2ML1

3.03e-03221102C0175704
DiseaseLung Neoplasms

A2M CYP1B1 PTEN CLCA2 MMP1

3.20e-032651105C0024121
DiseaseMalignant neoplasm of lung

A2M CYP1B1 PTEN CLCA2 MMP1

3.25e-032661105C0242379
Diseaseprimary open angle glaucoma (is_implicated_in)

CYP1B1 MMP1

3.31e-03231102DOID:1070 (is_implicated_in)
DiseaseDisease Exacerbation

FLT1 PTEN YY1 SYMPK

3.44e-031651104C0235874
DiseaseIntrahepatic Cholangiocarcinoma

PTEN PBRM1

3.60e-03241102C0345905
DiseaseExtrahepatic Cholangiocarcinoma

PTEN PBRM1

3.60e-03241102C3805278

Protein segments in the cluster

PeptideGeneStartEntry
YMGNEISYPLKPFLV

CDK5R1

236

Q15078
DMFGYFEPLYQVIPD

ACBD4

111

Q8NC06
LQLPDYYTIIKNPMD

BRDT

61

Q58F21
QYGQEVYDTPPMAVK

BCAR1

261

P56945
NVDYILPIMTQPYDF

AHI1

396

Q8N157
YPYDMARTPTQEQLL

AEBP1

771

Q8IUX7
MEFPSLDPNNNYIYV

FAT4

3986

Q6V0I7
QMPYPCYVDDIFLRV

ABCA1

621

O95477
MEDLVYNPEQVPRYY

A2ML1

421

A8K2U0
YPYLCEIMQFDLIPE

ARFGEF2

1736

Q9Y6D5
MLQFFYAYIQRIPVP

DOP1A

1901

Q5JWR5
PELFMQLVPQYYFSN

DHX32

686

Q7L7V1
VLMQTVDPYTPDYQD

ATP4B

61

P51164
NMVLFAPNIYVLDYL

A2M

976

P01023
CVNLFVMPYNYPVLL

INTS6

376

Q9UL03
RLLYDMFVNFPDQPV

INTS10

61

Q9NVR2
FEYQEPMPTAVLEKY

KIAA0895L

166

Q68EN5
QPLENYLDMEYFGTI

PGA5

66

P0DJD9
IYEPPRYMSVNQAAQ

DPH5

181

Q9H2P9
DNAPVFVNLPYYAVV

FAT1

2076

Q14517
LNQYLPNFYPLDMSE

FAT1

4486

Q14517
QPDYYEVVSQPIDLM

PBRM1

81

Q86U86
QSYPMVLQYRPRIDF

PCGF5

241

Q86SE9
IQGNLQLDYPIFYVM

NIPAL3

231

Q6P499
DQGDLMTPQFTPYYV

MAPKAPK5

176

Q8IW41
SLLDLPPVNEYDMYI

DYNC2I1

506

Q8WVS4
SLVPYTMTPEQFVDY

CSRNP3

466

Q8WYN3
YMPYPGRTNQEVLDF

LTK

721

P29376
AIMRTQVDPYLPYEY

MGAT5B

611

Q3V5L5
PLYAVMYPVFNELER

PDCD10

21

Q9BUL8
IEMLLITTNPYDYPF

MYH2

301

Q9UKX2
YAQYVKNTMEPLNIP

PDE5A

411

O76074
MFIPPSLIQLFDEYE

HACE1

766

Q8IYU2
YQPIAGLYEPATMEQ

MYO10

106

Q9HD67
LAMVDYPYASNFLQP

PRCP

286

P42785
IPEFYYLPEMFVNFN

LRBA

2361

P50851
MPYEYLRPSVVENSV

ALOX15

646

P16050
YNTTLPQFMPYEDGI

LY75

1391

O60449
PQFMPYEDGIYSVIQ

LY75

1396

O60449
PYNVMLYSDAPVSEL

MARCHF6

511

O60337
LVFNIQPAPGMVYDY

OVOS2

1406

Q6IE36
QPLENYLDMEYFGTI

PGA3

66

P0DJD8
PQYYIVVEMLEVPNK

MED14

546

O60244
LPFLIYQVMTDEPFQ

NPY1R

171

P25929
YPFNIEYQILASTML

OTOP1

271

Q7RTM1
YNPPRVQLSDEMFVF

CBY2

116

Q8NA61
MINFAPNIYILDYLT

CD109

926

Q6YHK3
MYRQHQASILEYLPP

CEP104

636

O60308
VELPVDVLYPYFMVQ

ILVBL

206

A1L0T0
PVPVIVNNFGMYYSL

KCNC1

431

P48547
DAQYPVVAVDSYMPV

C2CD3

921

Q4AC94
YAVTPIPDYVDVLQM

DOCK3

1421

Q8IZD9
QEFYDPMTPVNARYE

CLDN1

146

O95832
VYKFVSYPEILNMDP

ELK4

81

P28324
YLVYLPSQMFEPQKL

COL6A5

2231

A8TX70
PTFLQMCEPYFLYLE

C19orf67

126

A6NJJ6
FPQYQPVVMLEKGYT

CEMIP2

1031

Q9UHN6
MQYPVFPFILADYVS

LYST

3161

Q99698
VIQVPPEMRYTDYFV

MALSU1

111

Q96EH3
PNLPYVLAFLYEAMR

CYP1B1

376

Q16678
IGQEPPEMNLYYENF

FOXI1

21

Q12951
FYYMKQPLTTDPVDV

ZMYND8

66

Q9ULU4
LIPLLPQDFYYVAMD

SERHL2

51

Q9H4I8
TPYVDIDPFEMAAYL

RYK

541

P34925
DEPQLLYAIENKYMP

RYR2

1681

Q92736
EEVTRPNYPGIMYLQ

ENPP2

546

Q13822
EVILIVPFYDCYEPM

KYAT3

151

Q6YP21
TYIYPNIIAMGFPAE

PTEN

26

P60484
QPLENYLDMEYFGTI

PGA4

66

P0DJD7
PYGADDFLPVLMYVL

RIN3

781

Q8TB24
LAMSLDYDPLYVFNP

CFAP221

646

Q4G0U5
LIPLLPQDFYYVAMD

SERHL

51

Q9NQF3
KDPPQLDYTQMLLYF

SPEF2

1621

Q9C093
PDYIAPEVFMQTGYN

STK38

286

Q15208
KPQYSMAVEFPLVLY

PUS3

311

Q9BZE2
TMYLPSPEERNYEFL

GFM2

346

Q969S9
LYPFKNDEVLPVMYI

SNIP1

261

Q8TAD8
GPQPLYDFTSQYVME

RPGRIP1

671

Q96KN7
LQPPNYYEVMEFDPL

TOM1L1

436

O75674
SRTLEPYILPFMFYN

SMCHD1

1601

A6NHR9
LDSDYPPLQQFFVVM

RUFY2

36

Q8WXA3
LPPFYSQDVSQMYEN

SGK2

231

Q9HBY8
LPIYQDMTQPLNHYF

PLCD4

286

Q9BRC7
FYMRTNPFYPEVELN

MMP1

301

P03956
FVPDYYKVIVNPMDL

TAF1

1536

P21675
AQLPAVYPFAAAMYQ

IQGAP2

331

Q13576
VAINDPFIDLNYMVY

GAPDH

31

P04406
AYNQPEDLVYSQPEM

PTPN14

476

Q15678
QLMPYLVLDILQDYP

SLC5A8

321

Q8N695
PYTPFLTELMYQNLK

IARS1

771

P41252
EEVLFPQSDRFQPYM

IL22

101

Q9GZX6
YPDYIQIAMPTESRN

SGMS2

56

Q8NHU3
DFIEEYVTAYPNRPM

SETDB1

331

Q15047
PVMIYANVKQGFYPI

CLCA2

621

Q9UQC9
FPEIFYTFLQPYMAQ

PIK3R4

316

Q99570
IKPYIAEYDSPQNVM

TRMO

156

Q9BU70
EYAIQQTPYEQPMKS

ZFAT

246

Q9P243
IPAPYEYMQQQVYDE

TIAM2

866

Q8IVF5
QLLEDYSEPQPSMFY

RAPGEF1

556

Q13905
NYLIRYMPFAPAIQT

UBA7

891

P41226
PPLNVNEEYIIMGYE

FRZB

246

Q92765
PGEPMEKYQVLYQLN

STKLD1

21

Q8NE28
QIIGENSPPDYSEYM

YY1

241

P25490
FPSNYVEEMVNPVAL

PLCG1

841

P19174
QAYPEYLITYQIMRP

TNKS2

1146

Q9H2K2
YLPEAMPASFQAIYT

SYMPK

421

Q92797
QLDVYPVPNYLSYMD

PHLPP1

886

O60346
RLMEPYYFVEVQAPA

EFTUD2

826

Q15029
MYLVIFPEGTRYNPE

AGPAT5

166

Q9NUQ2
ADTLGYNIEPIMLYQ

VWA8

461

A3KMH1
APEYSTPEIYQIMLD

FLT1

1121

P17948
MLSEEPYIHANYQPV

TOPBP1

436

Q92547
MPQDYIQYTVPLDEG

SOCS6

216

O14544
IQYTVPLDEGMYPLE

SOCS6

221

O14544
ESPEMLYVVHPYVQF

WDR81

226

Q562E7
PVTYMLPADYNLFVE

TTLL1

111

O95922
FSPVVPYDMYILNAS

TBPL2

61

Q6SJ96
YEDIQYMQVPVADSP

DUSP18

61

Q8NEJ0