Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	AIM2 inflammasome complex	CASP1 CARD16	2.14e-05	4	40	2	GO:0097169
GeneOntologyCellularComponent	IPAF inflammasome complex	CASP1 CARD16	2.14e-05	4	40	2	GO:0072557
GeneOntologyCellularComponent	protease inhibitor complex	CASP1 CARD16	9.92e-05	8	40	2	GO:0097179
GeneOntologyCellularComponent	NLRP3 inflammasome complex	CASP1 CARD16	9.92e-05	8	40	2	GO:0072559
GeneOntologyCellularComponent	peptidase inhibitor complex	CASP1 CARD16	1.94e-04	11	40	2	GO:1904090
GeneOntologyCellularComponent	canonical inflammasome complex	CASP1 CARD16	5.36e-04	18	40	2	GO:0061702
GeneOntologyCellularComponent	myosin filament	MYOM2 MYH13	1.04e-03	25	40	2	GO:0032982
Domain	CARD	CASP1 CARD16	5.01e-04	16	39	2	SM00114
Domain	CARD	CASP1 CARD16	1.55e-03	28	39	2	PF00619
Domain	CARD	CASP1 CARD16	1.90e-03	31	39	2	IPR001315
Domain	SNF2_N	ERCC6 RAD54L	2.03e-03	32	39	2	PF00176
Domain	SNF2_N	ERCC6 RAD54L	2.03e-03	32	39	2	IPR000330
Domain	CARD	CASP1 CARD16	2.15e-03	33	39	2	PS50209
Pubmed	Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing.	CASP1 CARD16	7.73e-06	4	40	2	11432859
Pubmed	Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins.	CASP1 CARD16	1.29e-05	5	40	2	11536016
Pubmed	Meiotic functions of RAD18.	RAD18 RAD54L	1.93e-05	6	40	2	21807948
Pubmed	INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation.	CASP1 CARD16	1.93e-05	6	40	2	15383541
Pubmed	Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.	ERCC6 RAD54L	3.60e-05	8	40	2	9607915
Pubmed	Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.	CASP1 CARD16	4.62e-05	9	40	2	16920334
Pubmed	CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.	CASP1 CARD16	5.77e-05	10	40	2	11821383
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DIP2A NWD2 PLXNB2	1.40e-04	87	40	3	12465718
Pubmed	A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells.	CASP1 CARD16	1.53e-04	16	40	2	37225719
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	NWD2 GMEB2 SERINC1	2.30e-04	103	40	3	10574462
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	DIP2A MYOM2 ERCC6 MYH13 COPS7A	2.54e-04	497	40	5	36774506
Pubmed	Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney.	ALDH1A2 PLXNB2	3.21e-04	23	40	2	21035938
Pubmed	Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.	ERCC6 RAD54L	5.87e-04	31	40	2	20813000
Pubmed	Amino acid transport across mammalian intestinal and renal epithelia.	SLC7A9 SLC38A2	5.87e-04	31	40	2	18195088
Pubmed	Common genetic variants in candidate genes and risk of familial lymphoid malignancies.	CASP1 ERCC6 RAD54L	6.26e-04	145	40	3	19573080
Pubmed	TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.	ERCC6 COPS7A	8.37e-04	37	40	2	29531219
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	SLC38A2 DIP2A PTPRA PLXNB2	9.12e-04	377	40	4	38117590
Pubmed	Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.	PRPSAP2 NWD2 CNMD	9.27e-04	166	40	3	19906978
Pubmed	Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.	DIP2A HMGXB3	1.03e-03	41	40	2	8724849
Pubmed	Cockayne syndrome group A and ferrochelatase finely tune ribosomal gene transcription and its response to UV irradiation.	ERCC6 COPS7A	1.08e-03	42	40	2	34581821
GeneFamily	WD repeat domain containing\|Caspase recruitment domain containing\|Apoptosome	CASP1 CARD16	1.12e-03	30	30	2	959
Drug	1rww	CASP1 CARD16	3.01e-06	2	40	2	CID005289080
Drug	Diphenyl Ether Sulfonamide 10	CASP1 CARD16	3.01e-06	2	40	2	CID009887536
Drug	Biphenyl Sulfonamide 1	CASP1 CARD16	3.01e-06	2	40	2	CID010449481
Drug	1rwx	CASP1 CARD16	3.01e-06	2	40	2	CID005289610
Drug	Diphenyl Ether Sulfonamide 2	CASP1 CARD16	3.01e-06	2	40	2	CID015888281
Drug	Diphenyl Ether Sulfonamide 9	CASP1 CARD16	3.01e-06	2	40	2	CID015888283
Drug	Diphenyl Ether Sulfonamide 5	CASP1 CARD16	3.01e-06	2	40	2	CID015888282
Drug	arylsulfonamide analogue 16	CASP1 CARD16	3.01e-06	2	40	2	CID015888284
Drug	Diphenyl Ether Sulfonamide 7	CASP1 CARD16	3.01e-06	2	40	2	CID015888286
Drug	arylsulfonamide analogue 11	CASP1 CARD16	3.01e-06	2	40	2	CID015888279
Drug	Diphenyl Ether Sulfonamide 12	CASP1 CARD16	3.01e-06	2	40	2	CID010070710
Drug	AC1NR9V6	CASP1 CARD16	3.01e-06	2	40	2	CID005287535
Drug	AAF-cmk	CASP1 CARD16	3.01e-06	2	40	2	CID006610326
Drug	Cyclo(lys-pro)	CASP1 CARD16	3.01e-06	2	40	2	CID000194922
Drug	AC1NRAF8	CASP1 CARD16	3.01e-06	2	40	2	CID005287849
Drug	Dabcyl-ice-edans	CASP1 CARD16	9.02e-06	3	40	2	CID005748518
Drug	AC1NBJ9O	CASP1 CARD16	9.02e-06	3	40	2	CID004468934
Drug	AC1ODTZD	CASP1 CARD16	1.80e-05	4	40	2	CID007020821
Drug	AC1NUKW9	CASP1 CARD16	1.80e-05	4	40	2	CID005481610
Drug	cinchomeronate	CASP1 CARD16	1.80e-05	4	40	2	CID000010273
Drug	Nefopam hydrochloride [23327-57-3]; Down 200; 13.8uM; HL60; HT_HG-U133A	DIP2A HMGXB3 GMEB2 CLCN6 DTX4	2.26e-05	195	40	5	2355_DN
Drug	hqc	CASP1 CARD16	3.00e-05	5	40	2	CID005288581
Drug	Oxeclosporin	CASP1 CARD16	3.00e-05	5	40	2	CID006436153
Drug	Ac-YVAD-pNA	CASP1 CARD16	3.00e-05	5	40	2	CID000004338
Drug	AC1N3S5K	CASP1 CARD16	3.00e-05	5	40	2	CID004117381
Drug	AC1O0UZ8	CASP1 CARD16 TES	4.06e-05	38	40	3	CID006102762
Drug	NSC524461	CASP1 CARD16 TES	5.90e-05	43	40	3	CID000352040
Drug	rupintrivir	CASP1 CARD16	6.28e-05	7	40	2	CID006440352
Drug	Isatin analog 1	CASP1 CARD16	6.28e-05	7	40	2	CID000515950
Drug	F1-G	CASP1 CARD16	6.28e-05	7	40	2	CID006852193
Drug	Inhibitor 47c	CASP1 CARD16	6.28e-05	7	40	2	CID005327301
Drug	Inhibitor 66b	CASP1 CARD16	6.28e-05	7	40	2	CID005327309
Drug	catalpol	CASP1 CARD16	6.28e-05	7	40	2	CID000091520
Drug	Lysylproline	CASP1 CARD16 TES	8.22e-05	48	40	3	CID000171204
Drug	AC1N0FHX	CASP1 CARD16	8.37e-05	8	40	2	CID003916227
Drug	bestatin methyl ester	CASP1 CARD16	8.37e-05	8	40	2	CID009927170
Drug	Ac-wehd-cho	CASP1 CARD16	8.37e-05	8	40	2	CID005311140
Drug	hydrochalcone	CASP1 CARD16	8.37e-05	8	40	2	CID000064802
Drug	Isatin Sulfonamide 26	CASP1 CARD16	8.37e-05	8	40	2	CID009800285
Drug	M-IBDET	CASP1 CARD16	8.37e-05	8	40	2	CID005464042
Drug	denitro-nipradilol	CASP1 CARD16	8.37e-05	8	40	2	CID000135168
Drug	Isatin analog 2	CASP1 CARD16	8.37e-05	8	40	2	CID010826725
Drug	irofulven	CASP1 CARD16 ERCC6	9.87e-05	51	40	3	CID000148189
Drug	thiazepine	CASP1 CARD16	1.08e-04	9	40	2	CID012444276
Drug	Isatin Sulfonamide 29	CASP1 CARD16	1.08e-04	9	40	2	CID009821545
Drug	CpMn	CASP1 CARD16	1.08e-04	9	40	2	CID000146199
Drug	Ho Chi	CASP1 CARD16	1.08e-04	9	40	2	CID000128142
Drug	caprolactam	CASP1 CARD16	1.08e-04	9	40	2	CID000007768
Drug	Inhibitor 69b	CASP1 CARD16	1.08e-04	9	40	2	CID005327310
Drug	inhibitor 59	CASP1 CARD16	1.08e-04	9	40	2	CID005327305
Drug	Inhibitor 66a	CASP1 CARD16	1.08e-04	9	40	2	CID005327308
Drug	Inhibitor 64b	CASP1 CARD16	1.08e-04	9	40	2	CID005327307
Drug	AC1NS22C	CASP1 CARD16	1.08e-04	9	40	2	CID005327306
Drug	SA981	CASP1 CARD16	1.08e-04	9	40	2	CID000054805
Drug	DB07744	CASP1 CARD16 MYOM2	1.24e-04	55	40	3	CID011840941
Drug	CGP 31362	CASP1 CARD16	1.34e-04	10	40	2	CID006540671
Drug	dioxamate	CASP1 CARD16 MYOM2	1.60e-04	60	40	3	CID000045285
Drug	R x A	CASP1 CARD16	1.64e-04	11	40	2	CID000010640
Drug	merbarone	CASP1 CARD16	1.64e-04	11	40	2	CID004990817
Drug	progoitrin	CASP1 CARD16	1.96e-04	12	40	2	CID000656566
Drug	INCA-6	CASP1 CARD16	1.96e-04	12	40	2	CID000230748
Drug	Amrubicin [inn]	CASP1 CARD16	1.96e-04	12	40	2	CID000178149
Drug	tetraketide	CASP1 CARD16	2.32e-04	13	40	2	CID006475274
Drug	4-(methylthio)-3-butenyl isothiocyanate	CASP1 CARD16	2.32e-04	13	40	2	CID000103500
Drug	alpha-methylene-gamma-butyrolactone	CASP1 CARD16	2.32e-04	13	40	2	CID000068352
Drug	4-ethyl-2,3-dioxopiperazine	CASP1 CARD16	2.32e-04	13	40	2	CID000108812
Drug	leucinal	CASP1 CARD16	2.32e-04	13	40	2	CID000133915
Drug	theasinensin A	CASP1 CARD16	2.70e-04	14	40	2	CID000442543
Drug	DC 703	CASP1 CARD16	2.70e-04	14	40	2	CID000108134
Drug	MAHMA NONOate	CASP1 CARD16	2.70e-04	14	40	2	CID000188926
Drug	glucoiberin	CASP1 CARD16	2.70e-04	14	40	2	CID000656542
Drug	picolinamide	CASP1 CARD16	2.70e-04	14	40	2	CID000015070
Drug	alpha-angelicalactone	CASP1 CARD16	2.70e-04	14	40	2	CID000011559
Drug	Aapfcmk	CASP1 CARD16	3.11e-04	15	40	2	CID005487540
Drug	HCT1026	CASP1 CARD16	3.11e-04	15	40	2	CID000119387
Drug	Ac-YVAD-Amc	CASP1 CARD16	3.11e-04	15	40	2	CID000004337
Drug	AC1L2R2J	CASP1 CARD16	3.11e-04	15	40	2	CID000101552
Drug	Ambroxol hydrochloride [23828-92-4]; Down 200; 9.6uM; HL60; HG-U133A	RPUSD2 PTPRA PLXNB2 ZDHHC3	3.53e-04	192	40	4	1623_DN
Drug	pyrone	CASP1 CARD16	3.56e-04	16	40	2	CID000068154
Drug	Glutepar	CASP1 CARD16	3.56e-04	16	40	2	CID000020317
Drug	MKT-077	CASP1 CARD16	3.56e-04	16	40	2	CID006444403
Drug	AC1O60T9	CASP1 CARD16	3.56e-04	16	40	2	CID006444404
Drug	ConQuest	CASP1 CARD16	3.56e-04	16	40	2	CID000165708
Drug	caspase-1 inhibitor VI	CASP1 CARD16	3.56e-04	16	40	2	CID000644196
Drug	Methoxy-8-psoralen [298-81-7]; Up 200; 18.6uM; MCF7; HT_HG-U133A	SLC7A9 CASP1 CLCN6 ZFX	3.67e-04	194	40	4	3302_UP
Drug	Ivermectin [70288-86-7]; Down 200; 4.6uM; PC3; HT_HG-U133A	CASP1 RPUSD2 DIP2A ZFX	3.82e-04	196	40	4	2051_DN
Drug	Oxprenolol hydrochloride [6452-73-9]; Up 200; 13.2uM; MCF7; HT_HG-U133A	SLC7A9 ALDH1A2 CNMD ZFX	3.82e-04	196	40	4	7225_UP
Drug	estradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A_EA	DIP2A HMGXB3 CLCN6 ZFX	3.82e-04	196	40	4	1021_DN
Drug	Levodopa [59-92-7]; Down 200; 20.2uM; PC3; HG-U133A	TES GMEB2 PLXNB2 RAD54L	3.82e-04	196	40	4	1892_DN
Drug	Austricine [10180-88-8]; Down 200; 14.2uM; MCF7; HT_HG-U133A	CASP1 TES RAD54L ZFX	3.89e-04	197	40	4	2812_DN
Drug	Myosmine [532-12-7]; Down 200; 27.4uM; MCF7; HT_HG-U133A	SLC7A9 CASP1 PTPRA CLCN6	3.89e-04	197	40	4	6055_DN
Drug	2-propylpentanoic acid; Down 200; 1000uM; ssMCF7; HG-U133A	GMEB2 CLCN6 RAD54L ZFX	3.89e-04	197	40	4	497_DN
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; HL60; HG-U133A	CASP1 DIP2A PTPRA ZDHHC3	3.89e-04	197	40	4	2011_DN
Drug	Dyclonine hydrochloride [536-43-6]; Up 200; 12.2uM; PC3; HT_HG-U133A	CASP1 PPCDC PTPRA DTX4	3.97e-04	198	40	4	7261_UP
Drug	iloprost; Up 200; 1uM; MCF7; HG-U133A	PRPSAP2 RPUSD2 PTPRA KDM5A	3.97e-04	198	40	4	488_UP
Drug	Cyclizine hydrochloride [303-25-3]; Down 200; 13.2uM; HL60; HG-U133A	HMGXB3 CLCN6 KDM5A RAD54L	3.97e-04	198	40	4	1731_DN
Drug	Dorzolamide hydrochloride [130693-82-2]; Down 200; 11uM; MCF7; HT_HG-U133A	HMGXB3 PTPRA GMEB2 ZFX	3.97e-04	198	40	4	6259_DN
Drug	Myosmine [532-12-7]; Down 200; 27.4uM; MCF7; HT_HG-U133A	CASP1 ERCC6 CLCN6 KDM5A	3.97e-04	198	40	4	4759_DN
Drug	Ambotz208527-57-5	CASP1 CARD16	4.03e-04	17	40	2	CID010258704
Drug	di-u	CASP1 CARD16	4.03e-04	17	40	2	CID000008631
Disease	response to clopidogrel, response to acetylsalicylate, major adverse cardiovascular event measurement	MYOM2 ZDHHC3	5.78e-05	9	38	2	EFO_0020863, GO_1903492, GO_1903493
Disease	N6-acetyllysine measurement	SLC7A9 SLC38A2	7.22e-05	10	38	2	EFO_0800036
Disease	4-acetamidobutanoate measurement	ALDH1A2 PLXNB2	1.92e-04	16	38	2	EFO_0021003
Disease	level of Phosphatidylcholine (15:0_18:2) in blood serum	RAD18 ALDH1A2	2.44e-04	18	38	2	OBA_2045065
Disease	plasma betaine measurement	DCDC1 KDM5A	8.83e-04	34	38	2	EFO_0007787
Disease	serum metabolite measurement	SLC7A9 SLC38A2 CDC42BPG MYOM2 ALDH1A2 NWD2	1.22e-03	945	38	6	EFO_0005653
Disease	t-tau:beta-amyloid 1-42 ratio measurement	DIP2A ZDHHC3	3.29e-03	66	38	2	EFO_0007708
Disease	leucine measurement	ALDH1A2 DCDC1	4.01e-03	73	38	2	EFO_0009770
Disease	dilated cardiomyopathy (implicated_via_orthology)	PPCDC MYH13	4.79e-03	80	38	2	DOID:12930 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
VVTLAAKVKCIPYAV	COPS7A	101	Q9UBW8
KIAPALCCGNTVVIK	ALDH1A2	196	O94788
SLQCPTCKTIYGVKT	DTX4	461	Q9Y2E6
PVQVKTAYKCACVLR	ERCC6	721	Q03468
RKFVCPGINVKCVQY	GMEB2	106	Q9UKD1
GKQTPAFLKKCVCYI	NWD2	246	Q9ULI1
LKQVTKVDCPVCGVN	RAD18	196	Q9NS91
SKYLPVKIEQVVCCR	RAD54L	401	Q92698
CVAVKRQVLCYQLGP	CDC42BPG	1196	Q6DT37
KTRNEVCGYPVIVQK	DCDC1	1236	M0R2J8
TGGKIYKVCPHQVVC	HMGXB3	1056	Q12766
PCKVTKFGAQLQCVT	PLXNB2	936	O15031
CAITRKPGVYTKVCK	KLK11	256	Q9UBX7
KDGVCVCVYTPVGKA	NPEPPSL1	261	A6NEC2
EDYICINCAKKQGPV	KDM5A	1651	P29375
TGLLPKTKYVACVCV	LRIT1	486	Q9P2V4
KTKYVACVCVQGLVP	LRIT1	491	Q9P2V4
VKVVGIPGCQTCRYL	PRG2	96	P13727
EVKCYLNGVKVPGIV	CLCN6	161	P51797
VIPKGAQACQICITY	CASP1	61	P29466
VIRKGAPACQICITY	CARD17	61	Q5XLA6
YVGCKPPQIVVKCLA	SLC7A9	141	P82251
KCGNIVVYHVIVPCS	FAM72C	76	H0Y354
CVARAPPSCIKTYVK	DGKB	286	Q9Y6T7
CKTSCAKSIIGVIPY	PRPSAP2	96	O60256
ANVCVVKLEGTPYLC	DIP2A	726	Q14689
VIPKGAQACQICITY	CARD16	61	Q5EG05
KVKACNPQYAGAIVV	PTPRA	426	P18433
CKEPILVVSYKVGVC	RPUSD2	321	Q8IZ73
KPVCKPCYVKNHAVV	TES	346	Q9UGI8
YGAIKKLCCVQSPVP	PIWIL2	681	Q8TC59
KGVVPCNILVGYKAV	SERINC1	76	Q9NRX5
VIQELRKCCAQYPKG	CMC4	31	P56277
CYIKAQVKARIPEVG	CNMD	131	O75829
YVEIPCVAKKLVCGD	PPCDC	161	Q96CD2
GEKPYVCIICGKSFI	ZNF549	441	Q6P9A3
KPGQVVYKCPKCCSI	ZDHHC3	121	Q9NYG2
VICKKFQVPCPVEAA	SLC38A2	236	Q96QD8
LCCPRVKVGNEYVTK	MYH13	401	Q9UKX3
IIHTGVKPYICNVCS	ZFP69B	411	Q9UJL9
CKVDGTCPEVIKVYI	ZFX	241	P17010
VGYCITKPEVVCKLE	ZNF487	76	B1APH4
QCNDAPVKICKYPVT	MYOM2	431	P54296