Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncoumarin 7-hydroxylase activity

CYP2A6 CYP2A7 CYP2A13

1.63e-0731103GO:0008389
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

1.81e-07241105GO:0008392
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

3.39e-07271105GO:0008391
GeneOntologyMolecularFunctionaromatase activity

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

1.32e-06351105GO:0070330
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

7.28e-06491105GO:0016712
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP2A6 CYP2A7 CYP2A13 CYP2B6

3.56e-05341104GO:0008395
GeneOntologyMolecularFunctionmonooxygenase activity

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

4.39e-041151105GO:0004497
GeneOntologyBiologicalProcessepoxygenase P450 pathway

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

9.21e-08221095GO:0019373
GeneOntologyBiologicalProcesslong-chain fatty acid metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11 ACSL4 ACSBG1 ABCD1

3.11e-071241098GO:0001676
GeneOntologyBiologicalProcessphenylpropanoid metabolic process

CYP2A6 CYP2A7 CYP2A13

1.68e-05101093GO:0009698
GeneOntologyBiologicalProcesscoumarin metabolic process

CYP2A6 CYP2A7 CYP2A13

1.68e-05101093GO:0009804
GeneOntologyBiologicalProcessolfactory nerve formation

PLXNA3 PLXNA1

2.77e-0521092GO:0021628
GeneOntologyBiologicalProcessarachidonate metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

3.01e-05681095GO:0019369
GeneOntologyBiologicalProcessintracellular distribution of mitochondria

OGT LRRK2 CLUH

3.05e-05121093GO:0048312
GeneOntologyBiologicalProcessolefinic compound metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CEL CYP4A11 ABCD1

4.83e-051801097GO:0120254
GeneOntologyBiologicalProcessunsaturated fatty acid metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11 ABCD1

6.10e-051281096GO:0033559
GeneOntologyBiologicalProcessfatty-acyl-CoA metabolic process

ACSL4 ACSBG1 ABCD1 FAR1

7.08e-05421094GO:0035337
GeneOntologyBiologicalProcessfatty acid derivative metabolic process

CYP4A11 ACSL4 ACSBG1 ABCD1 FAR1

7.42e-05821095GO:1901568
GeneOntologyBiologicalProcessolfactory nerve morphogenesis

PLXNA3 PLXNA1

8.27e-0531092GO:0021627
GeneOntologyBiologicalProcessganglioside biosynthetic process

ST6GALNAC1 ST3GAL3 B4GALT6

1.11e-04181093GO:0001574
GeneOntologyBiologicalProcessfatty acid metabolic process

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11 ACSL4 PER2 ACSBG1 SLC22A13 ABCD1

1.67e-0446110910GO:0006631
DomainCyt_P450_E_grp-I_CYP2A-like

CYP2A6 CYP2A7 CYP2A13

7.92e-0741103IPR008067
DomainCyt_P450_E_grp-I

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

6.55e-06451105IPR002401
DomainCyt_P450_CS

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

1.48e-05531105IPR017972
DomainCYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

2.12e-05571105PS00086
Domain-

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

2.31e-055811051.10.630.10
Domainp450

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

2.31e-05581105PF00067
DomainCyt_P450

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

2.73e-05601105IPR001128
DomainTPR-like_helical_dom

OGT NAA15 WFS1 SNX20 COPB2 TMTC3 CLUH CRTAP

7.14e-052331108IPR011990
Domain-

OGT NAA15 WFS1 SNX20 TMTC3 CLUH CRTAP

2.25e-0420711071.25.40.10
DomainABC_TM1F

ABCC3 ABCB5 ABCD1

5.85e-04281103PS50929
DomainABC1_TM_dom

ABCC3 ABCB5 ABCD1

5.85e-04281103IPR011527
DomainSWIM

ZSWIM5 ZSWIM4

7.08e-0471102PF04434
DomainPlexin_cytopl

PLXNA3 PLXNA1

1.20e-0391102PF08337
DomainPlexin_cytoplasmic_RasGAP_dom

PLXNA3 PLXNA1

1.20e-0391102IPR013548
DomainPlexin

PLXNA3 PLXNA1

1.20e-0391102IPR031148
DomainZnf_SWIM

ZSWIM5 ZSWIM4

1.20e-0391102IPR007527
DomainZF_SWIM

ZSWIM5 ZSWIM4

1.20e-0391102PS50966
DomainPH

NIBAN2 MPRIP BTK PLCL2 PRKD1 PLCG1 SOS2

1.30e-032781107SM00233
DomainPH_DOMAIN

NIBAN2 MPRIP BTK PLCL2 PRKD1 PLCG1 SOS2

1.32e-032791107PS50003
DomainPH_domain

NIBAN2 MPRIP BTK PLCL2 PRKD1 PLCG1 SOS2

1.35e-032801107IPR001849
DomainABC_transporter_CS

ABCC3 ABCB5 ABCD1

1.93e-03421103IPR017871
DomainOTU

OTUD6B OTUD4

2.57e-03131102PF02338
DomainABC_tran

ABCC3 ABCB5 ABCD1

2.84e-03481103PF00005
DomainABC_TRANSPORTER_2

ABCC3 ABCB5 ABCD1

2.84e-03481103PS50893
DomainABC_TRANSPORTER_1

ABCC3 ABCB5 ABCD1

3.01e-03491103PS00211
DomainABC_transporter-like

ABCC3 ABCB5 ABCD1

3.19e-03501103IPR003439
DomainOTU

OTUD6B OTUD4

3.43e-03151102PS50802
DomainPLipase_C_Pinositol-sp_Y

PLCL2 PLCG1

3.43e-03151102IPR001711
DomainEF-hand_like

PLCL2 PLCG1

3.43e-03151102PF09279
DomainPIPLC_Y_DOMAIN

PLCL2 PLCG1

3.43e-03151102PS50008
DomainPI-PLC_fam

PLCL2 PLCG1

3.43e-03151102IPR001192
DomainPLC_EF-hand-like

PLCL2 PLCG1

3.43e-03151102IPR015359
DomainPI-PLC-Y

PLCL2 PLCG1

3.43e-03151102PF00387
DomainPLCYc

PLCL2 PLCG1

3.43e-03151102SM00149
DomainOTU_dom

OTUD6B OTUD4

3.43e-03151102IPR003323
DomainTPR_8

OGT NAA15 TMTC3

3.76e-03531103PF13181
DomainActin_CS

POTEF ACTG2

3.91e-03161102IPR004001
DomainACTINS_2

POTEF ACTG2

4.41e-03171102PS00432
DomainPept_M10A_stromelysin-type

MMP28 MMP17

4.95e-03181102IPR016293
DomainPI-PLC-X

PLCL2 PLCG1

4.95e-03181102PF00388
DomainActin/actin-like_CS

POTEF ACTG2

4.95e-03181102IPR020902
DomainPLCXc

PLCL2 PLCG1

4.95e-03181102SM00148
DomainPIPLC_X_DOMAIN

PLCL2 PLCG1

5.51e-03191102PS50007
DomainPLipase_C_PInositol-sp_X_dom

PLCL2 PLCG1

5.51e-03191102IPR000909
DomainACTINS_ACT_LIKE

POTEF ACTG2

5.51e-03191102PS01132
PathwayREACTOME_FATTY_ACIDS

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

6.79e-0818885MM14841
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A7 CYP2A13 CYP2B6

4.52e-0711884M27130
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A7 CYP2A13 CYP2B6

6.75e-0712884MM14847
PathwayREACTOME_FATTY_ACIDS

CYP2A7 CYP2A13 CYP2B6 CYP4A11

1.84e-0615884M27126
PathwayREACTOME_XENOBIOTICS

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.15e-0523884M5372
PathwayREACTOME_XENOBIOTICS

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.62e-0525884MM14846
PathwayWP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY

ABCC3 CYP2A6 CYP2B6 CYP4A11

3.92e-0531884M39476
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

4.13e-0562885M39653
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

4.82e-0564885M5650
PathwayKEGG_RETINOL_METABOLISM

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

4.82e-0564885M9488
PathwayWP_VALPROIC_ACID_PATHWAY

CYP2A6 CYP2B6 HDAC1

4.97e-0512883M39371
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

5.60e-0566885MM14839
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS

CYP2A6 CYP2A13

3.81e-045882M47808
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

4.78e-04104885M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

5.00e-04105885MM14842
PathwayWP_NICOTINE_METABOLISM_IN_LIVER_CELLS

CYP2A6 CYP2B6

5.69e-046882M39600
Pubmed

Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

9.83e-11411141970547
Pubmed

Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

8.85e-1015111529968852
Pubmed

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.47e-09611147668294
Pubmed

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.47e-09611148587134
Pubmed

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

1.81e-0917111527197076
Pubmed

Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.

CYP2A6 CYP2A13 CYP2B6 CEL TGM1

3.39e-0919111512721789
Pubmed

Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

3.41e-097111414630516
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

KNTC1 MYO1C DDX60 ZNFX1 PRPF8 MPRIP NBAS TMTC3 HECTD1

1.91e-08202111933005030
Pubmed

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

CYP2A6 CYP2A7 CYP2A13

3.16e-083111331645370
Pubmed

Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.

CYP2A6 CYP2A13 CYP2B6

3.16e-08311133219345
Pubmed

A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.

CYP2A6 CYP2A7 CYP2A13

3.16e-08311138297477
Pubmed

Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.

CYP2A6 CYP2A7 CYP2A13

3.16e-08311138188299
Pubmed

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.

CYP2A6 CYP2A7 CYP2A13

3.16e-08311138250953
Pubmed

The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.

CYP2A6 CYP2A7 CYP2A13

3.16e-08311132703500
Pubmed

Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.

CYP2A6 CYP2A13 CYP2B6

3.16e-08311131973143
Pubmed

Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.

CYP2A6 CYP2A7 CYP2A13

3.16e-083111322217847
Pubmed

Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.

CYP2A6 CYP2A7 CYP2A13

3.16e-083111322890016
Pubmed

Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.

CYP2A6 CYP2A7 CYP2A13

3.16e-08311133346244
Pubmed

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.

CYP2A6 CYP2A7 CYP2A13

3.16e-08311132733794
Pubmed

Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.

CYP2A6 CYP2A7 CYP2A13

3.16e-08311138484736
Pubmed

Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.

CYP2A6 CYP2A7 CYP2A13

3.16e-08311131417950
Pubmed

Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.

CYP2A6 CYP2A7 CYP2A13

3.16e-083111324045421
Pubmed

Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.

CYP2A6 CYP2A7 CYP2A13

3.16e-083111332987105
Pubmed

Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.

CYP2A6 CYP2A7 CYP2A13

3.16e-08311132765478
Pubmed

Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.

CYP2A6 CYP2A7 CYP2A13

3.16e-08311132415518
Pubmed

Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.

CYP2A6 CYP2A7 CYP2A13

1.26e-074111310490589
Pubmed

Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5.

CYP2A6 CYP2A13 CYP2B6

1.26e-074111324494203
Pubmed

Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.

CYP2A6 CYP2A7 CYP2A13

1.26e-07411139408084
Pubmed

A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.

CYP2A6 CYP2A7 CYP2A13

1.26e-07411137565685
Pubmed

Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0.

MYO1C COPB2 FAM91A1 PRPF8 MPRIP WDR11 OTUD4

1.54e-07124111735516420
Pubmed

Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

2.97e-0744111512745259
Pubmed

Molecular genetics of the human cytochrome P450 monooxygenase superfamily.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

4.58e-072011149890157
Pubmed

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.

CYP2A6 CYP2A7 CYP2A13

1.10e-06711139630227
Pubmed

Resveratrol improves health and survival of mice on a high-calorie diet.

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.39e-0626111417086191
Pubmed

Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.

CYP2A6 CYP2A7 CYP2A13

2.62e-069111337838304
Pubmed

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.

ABCC3 CYP2A6 CYP2A13 CYP2B6 CYP4A11 TGM1 ABCD1

3.03e-06193111719343046
Pubmed

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

3.10e-0670111515128046
Pubmed

SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System.

SOX4 SOX11 PLXNA1

3.74e-0610111328215559
Pubmed

Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.

CYP2A6 CYP2A7

1.01e-052111212325023
Pubmed

Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.

CYP2A6 CYP2A13

1.01e-052111230876690
Pubmed

Differential expression of SOX4 and SOX11 in medulloblastoma.

SOX4 SOX11

1.01e-052111212125983
Pubmed

CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.

CYP2A6 CYP2A13

1.01e-052111221395539
Pubmed

Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.

CYP2A6 CYP2A13

1.01e-052111212162851
Pubmed

Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.

CYP2A6 CYP2A13

1.01e-05211121302041
Pubmed

Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.

CYP2A6 CYP2A13

1.01e-05211128395817
Pubmed

Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.

CYP2A6 CYP2A13

1.01e-052111225804444
Pubmed

SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.

SOX4 SOX11

1.01e-052111222378879
Pubmed

Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.

CYP2A6 CYP2A13

1.01e-05211121520280
Pubmed

Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism.

CYP2A6 CYP2B6

1.01e-052111218004205
Pubmed

Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.

CYP2A6 CYP2A13

1.01e-052111223917075
Pubmed

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.

CYP2A6 CYP2A7

1.01e-052111216636685
Pubmed

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.

CYP2A6 CYP2A13

1.01e-052111227902773
Pubmed

Bruton's tyrosine kinase (Btk) associates with protein kinase C mu.

BTK PRKD1

1.01e-052111210561498
Pubmed

Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin.

CYP2A6 CYP2B6

1.01e-052111228886044
Pubmed

Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase.

ACSBG1 ABCD1

1.01e-052111214516277
Pubmed

Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.

CYP2A6 CYP2A13

1.01e-052111230154104
Pubmed

Expression of CYP2A genes in human liver and extrahepatic tissues.

CYP2A7 CYP2A13

1.01e-052111210353262
Pubmed

CYP2B6 (c.516G-->T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients.

CYP2A6 CYP2B6

1.01e-052111219371316
Pubmed

Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.

CYP2A6 CYP2A13

1.01e-052111221418183
Pubmed

Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.

CYP2A6 CYP2A13

1.01e-052111219923441
Pubmed

Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.

CYP2A6 CYP2A13

1.01e-052111212499123
Pubmed

Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.

CYP2A6 CYP2A13

1.01e-052111222497566
Pubmed

The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.

CYP2A6 CYP2A13

1.01e-052111226363552
Pubmed

Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.

CYP2A6 CYP2A13

1.01e-05211122712571
Pubmed

Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants.

CYP2A6 CYP2B6

1.01e-052111228931220
Pubmed

Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.

CYP2A6 CYP2A13

1.01e-052111222696418
Pubmed

Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification.

PCNA HDAC1

1.01e-052111211929879
Pubmed

O-GlcNAcylation of histone deacetylases 1 in hepatocellular carcinoma promotes cancer progression.

OGT HDAC1

1.01e-052111227060025
Pubmed

Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.

CYP2A6 CYP2A13

1.01e-052111230222954
Pubmed

Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.

CYP2A6 CYP2A13

1.01e-05211127543189
Pubmed

Characterization and regulation of sex-specific mouse steroid hydroxylase genes.

CYP2A6 CYP2A13

1.01e-05211122372744
Pubmed

Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.

MIER1 HDAC1

1.01e-052111212482978
Pubmed

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

CYP2A6 CYP2A7

1.01e-05211122322567
Pubmed

Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.

CYP2A6 CYP2A13

1.01e-052111221473878
Pubmed

The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.

CYP2A6 CYP2A13

1.01e-05211127581481
Pubmed

Expression and alternative splicing of the cytochrome P-450 CYP2A7.

CYP2A6 CYP2A7

1.01e-05211127864805
Pubmed

Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.

CYP2A6 CYP2A13

1.01e-052111228298240
Pubmed

Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.

CYP2A6 CYP2A13

1.01e-05211126309775
Pubmed

Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase.

BTK GNAQ

1.01e-05211129770463
Pubmed

Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.

CYP2A6 CYP2A13

1.01e-052111222262919
Pubmed

Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.

CYP2A6 CYP2A13

1.01e-052111225635819
Pubmed

Genetic variation between mice in their metabolism of coumarin and its derivatives.

CYP2A6 CYP2A13

1.01e-0521112566237
Pubmed

Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.

CYP2A6 CYP2A13

1.01e-05211128611142
Pubmed

Human Neuropeptide S Receptor Is Activated via a Gαq Protein-biased Signaling Cascade by a Human Neuropeptide S Analog Lacking the C-terminal 10 Residues.

NPSR1 GNAQ

1.01e-052111226865629
Pubmed

Coumarin toxicity in different strains of mice.

CYP2A6 CYP2A13

1.01e-0521112665441
Pubmed

Determinants of the rate of nicotine metabolism and effects on smoking behavior.

CYP2A6 CYP2B6

1.01e-052111217015050
Pubmed

Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.

CYP2A6 CYP2A13

1.01e-052111224104196
Pubmed

The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells.

SOX4 SOX11

1.01e-052111223318640
Pubmed

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

MYO1C LRRK2 ACTG2 MPRIP

1.10e-0543111420876399
Pubmed

Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.

CYP2A6 CYP2A13 CYP2B6

1.12e-0514111319290787
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

SOX4 PLXNA3 ABCC3 KMT5C MTG2 MPRIP LATS2 PER2 PLCG1 ABCD1 MMP17 HECTD1 MED12 PLXNA1

1.18e-0511051111435748872
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

ABCC3 NIBAN2 MIER1 CCNY TGM1 LATS2 PTPRJ GNAQ VPS51 PLXNA1

1.49e-055691111030639242
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

KNTC1 OGT NAA15 NCKAP1 POLR2B COPB2 NIBAN2 DPP9 OTUD6B PLCG1 HECTD1 CLUH ELP4 PCNA HDAC1 CRTAP

1.56e-0514551111622863883
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

PLXNA3 RHOJ POLR2B ACSL4 TGM1 CKS2 LATS2 DPP9 MMP17 PLXNA1 HDAC1

2.28e-057301111134857952
Pubmed

Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex.

SOX4 SOX11 CCNY

2.95e-0519111334431536
Pubmed

Histone deacetylase 1 regulates the malignancy of oral cancer cells via miR-154-5p/PCNA axis.

PCNA HDAC1

3.02e-053111232549181
Pubmed

Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.

CYP2A6 CYP2A13

3.02e-053111218068688
Pubmed

CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.

CYP2A6 CYP2A7

3.02e-053111211960914
Pubmed

SOX4, SOX11 and PAX6 mRNA expression was identified as a (prognostic) marker for the aggressiveness of neuroendocrine tumors of the lung by using next-generation expression analysis (NanoString).

SOX4 SOX11

3.02e-053111225804118
Pubmed

Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.

CYP2A6 CYP2A13

3.02e-05311127849402
InteractionCYP2A7 interactions

CYP2A6 CYP2A7 CYP2A13

1.46e-0731073int:CYP2A7
InteractionLRRC31 interactions

KNTC1 MYO1C DDX60 ZNFX1 PRPF8 MPRIP NBAS TMTC3 HECTD1

1.48e-062051079int:LRRC31
GeneFamilyCytochrome P450 family 2

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.03e-05358441001
GeneFamilyZinc fingers SWIM-type|Mitogen-activated protein kinase kinase kinases

ZSWIM5 ZSWIM4

7.52e-04984290
GeneFamilyPlexins

PLXNA3 PLXNA1

7.52e-049842683
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

MPRIP BTK PRKD1 PLCG1 SOS2

2.73e-03206845682
GeneFamilyOTU domain containing

OTUD6B OTUD4

2.77e-0317842669
GeneFamilyBeta 4-glycosyltransferases

B4GALT6 CHSY3

2.77e-0317842425
GeneFamilySRY-boxes

SOX4 SOX11

3.46e-0319842757
GeneFamilyPhospholipases|C2 domain containing phospholipases

PLCL2 PLCG1

3.46e-0319842832
GeneFamilySialyltransferases

ST6GALNAC1 ST3GAL3

3.84e-0320842438
GeneFamilyEndogenous ligands|Matrix metallopeptidases

MMP28 MMP17

5.51e-0324842891
GeneFamilyAcyl-CoA synthetase family

ACSL4 ACSBG1

6.45e-032684240
CoexpressionWENG_POR_DOSAGE

CYP2A6 CYP2A7 CYP2A13 CYP2B6

6.88e-06301084MM1199
CoexpressionRHODES_CANCER_META_SIGNATURE

SOX4 OGT COPB2 CKS2 HDAC1

7.34e-06651085M1345
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX11 STAB2 RHOJ WFS1 TMOD2 CHSY3 MMP17

5.03e-071901117876bd2eb9ed2624cb23bdcf6b989e4fa34d099e3
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX11 STAB2 RHOJ WFS1 TMOD2 CHSY3 MMP17

5.03e-071901117be9f36127028f52ca5fc1b32ba15a6c26aad69ac
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SOX11 STAB2 RHOJ WFS1 TMOD2 CHSY3 MMP17

5.03e-07190111709a8855901c3c9332dbaab3e40166485b696d0f1
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ST6GALNAC1 CYP2A6 CYP2A7 CYP2A13 CYP2B6 NCKAP1

4.97e-06174111642f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCellControl-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

SOX4 ABCC3 CYP2A6 CYP2A7 CYP2A13 CYP2B6

7.05e-0618511166814b3c94c7558443c038a227b5c8563d2cfeac4
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TENT5A ST3GAL3 CHN2 ITGAV IL1RAPL1 ACSL4

7.27e-061861116de55471dd5c842026b409cfebf67fe32f079a011
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ST6GALNAC1 CYP2A6 CYP2A7 CYP2A13 CYP2B6 MSLN

8.98e-061931116605fc2a25ed6846fb283b2918cfed98df6039d6b
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TENT5A CHN2 IL1RAPL1 ACSL4 CKS2 BTK

8.98e-061931116c17e87c042ef095ac99fdd6facf3bc2886924dc4
ToppCellGoblet|World / shred by cell class for turbinate

ST6GALNAC1 CYP2A6 CYP2A13 CYP2B6 ABCD1 MSLN

9.25e-06194111603b62e7cff5e7a6e7bd7d9dda273c74bf9c1f42e
ToppCellTracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SNX20 POTEF CKS2 SLC46A3 CD226 PCNA

9.80e-061961116b71d711be5609115b00a57700885aca608920896
ToppCellcritical-Epithelial-Secretory|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

ST6GALNAC1 SOX4 CYP2B6 NCKAP1 PER2 MSLN

9.80e-0619611167da687eb983a54c28ee990424cc52e01caf5f4aa
ToppCelldistal-1-Epithelial-Club|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ST6GALNAC1 SOX4 CYP2A6 CYP2A7 CYP2A13 NIBAN2

1.07e-0519911168f0a72a95d0310ef2324c6975495c294b5a47cc8
ToppCelldistal-3-Epithelial-Club|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ST6GALNAC1 SOX4 CYP2A6 TENT5A NIBAN2 MSLN

1.07e-0519911161a0c3506df2438f5be40a8ea72effe5f8ebd35c4
ToppCelldistal-Epithelial-Club|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ST6GALNAC1 SOX4 CYP2A6 CYP2A7 NIBAN2 MSLN

1.07e-051991116c63ccce1285352927fd8c4f7374ec5fff8d70cec
ToppCelldistal-Epithelial-Club-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ST6GALNAC1 SOX4 CYP2A6 CYP2A7 CYP2A13 NIBAN2

1.07e-051991116685cefbe6ff5db8b578e50b5849524ac2f347d0c
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Mast_cell-Mast_cell|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SOX4 IL1RAPL1 ACSL4 CKS2 BTK ZSWIM4

1.10e-052001116a338b2b94901e4614ef78e82f580b67891f7c849
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Mast_cell|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SOX4 IL1RAPL1 ACSL4 CKS2 BTK ZSWIM4

1.10e-05200111621de2cf284c8d2aa464f3d403f0e292e1f654e0a
ToppCellpdx-Tumor_cells-T9|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SOX4 POLR2B TMOD2 ZNFX1 LATS2

3.06e-0514411150b94d978262a826c9254145aa98c6c30240243f9
ToppCelldroplet-Lung-nan-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENT5A LRRC58 CKS2 SLC46A3 PTPRJ

4.08e-0515311156dcab3d50ab50051955204dc4e4a64c1ca855bcd
ToppCelldroplet-Lung-nan-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENT5A LRRC58 CKS2 SLC46A3 PTPRJ

4.08e-051531115f6ef14d949107c08cb3690e26ec91e194cb43518
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENT5A MIER1 PTPRJ PLCL2 FAR1

4.48e-051561115d72c2f5f72d269e29033f8728d924e0d4c8772c7
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D122|Adult / Lineage, Cell type, age group and donor

ST6GALNAC1 CYP2B6 MMP28 LRRK2 ST3GAL3

4.62e-05157111531d1bd9138c60e8485664ec4144f987226e3eef9
ToppCelldroplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SNX20 TENT5A CKS2 SLC46A3 PTPRJ

5.52e-051631115f6c8db5963ee1f8e0c2996f1aeecd58c00e9b099
ToppCelldroplet-Lung-3m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SNX20 TENT5A CKS2 SLC46A3 PTPRJ

5.68e-051641115ea2897942ad72fba900c7ab354d6a9e203bf0e4a
ToppCellClub_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

ST6GALNAC1 SOX4 CYP2A6 CYP2A13 GLB1L3

6.19e-051671115dbdaaeb3bd9139cb008d9fe24ec031fc5628f136
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLXNA3 ST3GAL3 ADAM32 ACSL4 ZSWIM4

6.37e-05168111555f328353119cbdc521c782ebb8d163876f4186d
ToppCellControl-Lymphoid-ILC_B|Lymphoid / Disease state, Lineage and Cell class

SOX4 SOX11 RNF113B LATS2 GNAQ

6.37e-051681115d7118d39253ed9790908b850088ebfc5a86f4065
ToppCellfacs-Lung-nan-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAN2A1 MMP28 OTUD6B PRKD1 ZSWIM4

6.73e-0517011158e1f757ed62218c0fb6525f49d142dd2cd29acf9
ToppCellfacs-Lung-nan-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAN2A1 MMP28 OTUD6B PRKD1 ZSWIM4

6.73e-05170111567d7e1da3ebd2d14cb2e67799e94d655027ed5c4
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SNX20 AGPAT1 CHN2 SLC46A3 CD226

6.92e-0517111151018d7bd378ce20bee56a77d5851b3538c55098c
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GALNAC1 CYP2A7 CYP2A13 CYP2B6 MSLN

6.92e-05171111525c1979e972c959e1ce4c57804f976f53a247ad7
ToppCellfacs|World / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NCKAP1 RHOJ ACSL4 PLCG1 GNAQ

6.92e-051711115bb71e816dde44fda6af0ad98d979be9f8740fda6
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GALNAC1 CYP2A7 CYP2A13 CYP2B6 MSLN

6.92e-051711115fe27bf581c75ef33c2848878e51ed16b275a4c8e
ToppCellfacs-Lung-EPCAM-18m-Myeloid-Myeloid_Dendritic_Type_1|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX20 TENT5A CHN2 B4GALT6 SLC46A3

6.92e-0517111157c4362eeacbe52d7f4fdf93c841d7b59526328c1
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)-DC1_L.1.2.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SNX20 AGPAT1 CHN2 SLC46A3 CD226

6.92e-0517111156bda333bb751d7835a04f21ac959eea79f2516aa
ToppCellfacs|World / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCKAP1 RHOJ ACSL4 PLCG1 GNAQ

6.92e-0517111155bcb96ed7fc15548f2dc9cf47482f890640cb39c
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SNX20 AGPAT1 CHN2 SLC46A3 CD226

6.92e-051711115173bb5318fdbaef6e695b6f9e3e0ff4a5432a1a4
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MMP28 LRRK2 SLC46A3 CD226 CHSY3

7.31e-05173111570c0c13febd28b395fb3171ec8d7fbbc6c9d4eb7
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

STAB2 SLC46A3 BTK MMP17 PLXNA1

7.31e-05173111520f7dfe7d92a3dbec9da9a1f3185aa10cb8f0a3c
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

EXO5 B4GALT6 CHSY3 PLXNA1 ELP4

7.31e-0517311157e2149205e119cec4f5099c83c85d1e13470137a
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CYP2A6 CYP2A7 CYP2B6 NIBAN2 CHSY3

8.37e-051781115f5ed4a6e3eb8056b1be1fb311021710c95bdf888
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAN2A1 TMOD2 ITGAV IL1RAPL1 MSLN

8.59e-051791115adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

CYP2A6 CYP2A7 CYP2B6 LRRK2 NIBAN2

9.05e-051811115c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STAB2 RHOJ WFS1 CHSY3 MMP17

9.29e-05182111541b070085edba7a58b81c20aa4942d06f745acf8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STAB2 RHOJ WFS1 CHSY3 MMP17

9.29e-0518211155e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STAB2 RHOJ WFS1 CHSY3 MMP17

9.29e-051821115b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

STAB2 RHOJ WFS1 TMOD2 CHSY3

9.29e-05182111553c267ee327e116dbd89d5927ed3bdf78d25ee62
ToppCellPCW_10-12-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SNX20 LRRK2 CHN2 SLC46A3 CD226

9.78e-051841115315bb14e848d8e8e4533122047df6f9b89b89d99
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TENT5A CHN2 ITGAV IL1RAPL1 ACSL4

1.00e-0418511153fafb1d36c5f98a29d20a5ce5192c83d6f603514
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TENT5A CHN2 IL1RAPL1 ACSL4 BTK

1.03e-041861115f690e26b2ed024bd8ede494b8e9a00976fdc9734
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TENT5A CHN2 IL1RAPL1 ACSL4 BTK

1.05e-041871115bdcef4f3e093c3646b639a189bbe93d6f4c40f3c
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TENT5A CHN2 IL1RAPL1 ACSL4 BTK

1.05e-04187111509348f1e8bbbca8dca885461937b9b1dd248b034
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TENT5A CHN2 IL1RAPL1 ACSL4 BTK

1.05e-0418711150f7a42c55997e34a0d20e492e16b03e91e965335
ToppCell5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TENT5A CHN2 IL1RAPL1 ACSL4 BTK

1.05e-041871115064730fa72f8637c3db3fc34d2e363d2b9a38f1d
ToppCellfacs-Spleen-nan-3m-Lymphocytic-B_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO1C LRRK2 LRRC58 PTPRJ BTK

1.05e-0418711153ca3954f45f167e98a230f2847f0582d74fcd32e
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

ST6GALNAC1 CYP2A6 CYP2A7 CYP2B6 CHSY3

1.16e-04191111523776c7302cead3881b39127398f3b3e0d27885e
ToppCellIPF-Epithelial-Club|World / Disease state, Lineage and Cell class

CYP2A6 CYP2A7 CYP2B6 NCKAP1 MSLN

1.16e-0419111153c88a6f1d74bb3b9173cd0ea3a63c6d9570e3954
ToppCellNS-critical-d_16-33-Epithelial-Secretory-diff|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ST6GALNAC1 CYP2A7 CYP2A13 CYP2B6 MSLN

1.19e-04192111502b11233b4da2d85b96498b3c6e22e3a31b3d049
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TENT5A CHN2 IL1RAPL1 ACSL4 BTK

1.19e-04192111560a02e0ccdc8c7af9bc875b248467304fe0d24a4
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TENT5A CHN2 IL1RAPL1 ACSL4 BTK

1.19e-041921115b223fca73e16668f69a78cf4457e349d01792540
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TENT5A CHN2 IL1RAPL1 ACSL4 BTK

1.19e-041921115b5615a780b0ba24a8e554fac9238d3f0bcba52bc
ToppCell3'-Parenchyma_lung-Immune_Myeloid_mast|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TENT5A CHN2 IL1RAPL1 ACSL4 BTK

1.19e-0419211155532ea1bc012eb9303197b87e90bc39619b5ee2a
ToppCellcontrol-Lymphoid-CTL|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

OGT CHN2 PTPRJ CD226 PLCG1

1.22e-04193111589d407a88b5956559a589425b89b3eb8dc78e1dd
ToppCellmyeloid-CD34+_Myeloblast|World / Lineage and Cell class

SOX4 TENT5A B4GALT6 CKS2 PCNA

1.25e-041941115426d5cf04e21fec2fb6ea51abd85441b2dc5c94f
ToppCelldroplet-Limb_Muscle-MUSCLE|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SOX11 LRRC58 MIER1 PER2 HECTD1

1.25e-041941115e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SOX4 CYP2A6 TENT5A NIBAN2 MSLN

1.25e-041941115db06ae2dba45640da329a4d0d94973ac9dda7729
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SOX4 CYP2A6 TENT5A NIBAN2 MSLN

1.25e-041941115d3f5cd6c40354bfe86348bb0e82697a939759625
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GALNAC1 SOX4 CYP2A6 CYP2A7 CYP2B6

1.25e-0419411150cd4363627acd419e00d6d32f6dce10430aa6487
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SOX4 CYP2A6 TENT5A NIBAN2 MSLN

1.25e-041941115d4f4036b650a27312283fa8851f3975595cc2d3f
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-epithelial_cell_of_lung|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SOX4 CYP2A6 TENT5A NIBAN2 MSLN

1.25e-0419411154974c208e6ee37a51cd95a61d48b26c5de416992
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ST6GALNAC1 SOX4 CYP2A6 CYP2A7 CYP2B6

1.25e-041941115a58841b34efe673671a9a059238e044a7254b279
ToppCell10x5'v1-week_17-19-Endothelial-stroma-sinusoidal_EC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

STAB2 NCKAP1 RHOJ CHSY3 FBXO39

1.28e-04195111522a481927147ec4ae9d59e6af7c87df0e9cb51e4
ToppCellnormal_Lung-Epithelial_cells-Club|normal_Lung / Location, Cell class and cell subclass

ST6GALNAC1 SOX4 CYP2A6 CYP2A7 CYP2A13

1.28e-041951115b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCellEpithelial_cells-Club_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

ST6GALNAC1 SOX4 ABCC3 CYP2A6 CYP2A7

1.28e-041951115b758676abfc4e6930b696d270ecc0ea461b87a54
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ST6GALNAC1 CYP2A6 CYP2A7 CYP2B6 CHSY3

1.28e-041951115dccc32fcf772e2504de7f663ef0a5bd8e23e92fc
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Club|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ST6GALNAC1 SOX4 CYP2A6 CYP2A7 CYP2B6

1.28e-041951115b9e8f405f6d837bb39b615836d3e2df349737c0e
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ST6GALNAC1 SOX4 CYP2A13 PER2 MSLN

1.28e-0419511156095bb237d7bc75cbaeaeb492f6948f3c3fa4848
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Club|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ST6GALNAC1 CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.31e-0419611154e4c632db73b1340d80bf40a7657cb4821084d3c
ToppCellCOPD-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

SOX4 ABCC3 CYP2B6 MPRIP ZSWIM4

1.31e-041961115af96fb94886e9395f3e2cd0a293af29229d017fe
ToppCellAT1_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

MYO1C WFS1 TGM1 PLXNA1 MSLN

1.35e-04197111580d81be244c94c435accb643449b4ce6a3462c7f
ToppCell3'_v3-GI_small-bowel-Mast-Mast_cells|GI_small-bowel / Manually curated celltypes from each tissue

SOX4 TENT5A IL1RAPL1 ACSL4 BTK

1.38e-041981115920d2e6603a06c2e8dcb6be127202d222c662bca
ToppCell367C-Epithelial_cells-Epithelial-E_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LRRK2 NIBAN2 ACSL4 CKS2 MSLN

1.38e-04198111585215015bb86ada0e871c413a4ecdc903a3785ca
ToppCelldistal-Epithelial-Club-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ST6GALNAC1 SOX4 CYP2A6 TENT5A MSLN

1.38e-041981115e56a5ffadfa4d1e34d34aec43eaf560cd80286e1
ToppCellnormal_Lung-Epithelial_cells-Club|Epithelial_cells / Location, Cell class and cell subclass

SOX4 ABCC3 CYP2A6 CYP2A7 CYP2A13

1.38e-041981115a9d0109ca05eb3e9c588f9677ec471dd5c092a75
ToppCellBiopsy_Control_(H.)-Epithelial-SCGB3A2+_SCGB1A1+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

ST6GALNAC1 SOX4 CYP2A6 CYP2A7 CYP2A13

1.38e-041981115a3d4b6e4259ded2193d94d2ff6d48cf67214fc35
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Club|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ST6GALNAC1 SOX4 CYP2A6 CYP2A13 CYP2B6

1.38e-0419811155d57acbe0d245f8bd217eeea07af060092898fbd
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Club|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ST6GALNAC1 SOX4 CYP2A6 CYP2B6 CHSY3

1.38e-0419811151408e02e053ad3406229bfe8189da03be6366e81
ToppCellcritical-Epithelial-FOXN4+|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

SOX4 USP13 CKS2 PCNA MSLN

1.38e-0419811156b160b3d6a2c1b1641c2c7dcec1a7ef38411fec9
ToppCellBiopsy_Other_PF-Immune-Mast_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

CHN2 IL1RAPL1 ACSL4 NBAS BTK

1.38e-0419811159f015553598d4c6774b2f9759e8c0f0f93e51c67
ToppCellBiopsy_Control_(H.)-Epithelial-SCGB3A2+|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

ST6GALNAC1 SOX4 CYP2A6 CYP2B6 MSLN

1.38e-0419811151fe51f4beca0eef4ff117e6edaa646e35c0f9629
ToppCell3'_v3-GI_small-bowel-Mast|GI_small-bowel / Manually curated celltypes from each tissue

SOX4 TENT5A IL1RAPL1 ACSL4 BTK

1.38e-041981115807e3ed34739eca159dd0970f884b073e588c649
ToppCellEpithelial_cells-AT1-AT2_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

SOX4 ABCC3 MYO1C WFS1 PLXNA1

1.38e-041981115fbc46b20bcd44f2083170aacbc6f5dd00fba685c
ToppCell367C-Epithelial_cells-Epithelial-E_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LRRK2 NIBAN2 ACSL4 CKS2 MSLN

1.38e-04198111538349e42a3f1fb700ff6dfd89c4bf5ff97f1a3e9
ToppCell10x3'2.3-week_14-16-Endothelial|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

STAB2 NCKAP1 RHOJ WFS1 FBXO39

1.41e-04199111541f046646fff65b7e51b63d3204f76ef32054781
ToppCellproximal-Epithelial-Club|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX4 CYP2A6 TENT5A NIBAN2 MSLN

1.41e-04199111599d23c0373f1ae5267bb3e51c5c88c8f52559ae4
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Transitional_AT2|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CYP2A6 CYP2A7 CYP2B6 NIBAN2 MSLN

1.41e-041991115b44d74895846e2ac144438b73e0ca91e3949c16c
ToppCell(7)_Epithelial_cells-(7)_Epithelial-I_(AT1)|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

ABCC3 MYO1C WFS1 DDX60 PLXNA1

1.41e-0419911155a002d49a8b84c158f7b4d7a3e78e6a937757bb7
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Transitional_AT2-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CYP2A6 CYP2A7 CYP2B6 NIBAN2 MSLN

1.41e-0419911154b374a5de82b4614d3d8a00202ea6cb8f1fd8104
ToppCellBiopsy_IPF-Epithelial-Transitional_AT2|Biopsy_IPF / Sample group, Lineage and Cell type

MYO1C MMP28 LRRK2 NIBAN2 MSLN

1.41e-04199111583ff8b7e472d1212324c05cc719b746d19e5e23b
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Club|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

ST6GALNAC1 CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.41e-0419911152b17694cffbec28a2c8f165dfcff6bab94aa0f4c
Drug2'-methoxyacetophenone

CYP2A6 CYP2A7 CYP2A13

1.13e-0731113CID000068481
Drugd 6-20

CYP2A6 CYP2A13 CYP2B6 ABCB5

3.70e-07131114CID000161569
Drug7-benzyloxyquinoline

CYP2A6 CYP2B6 CYP4A11 ABCB5

1.55e-06181114CID003035604
DrugD 703

CYP2A6 CYP2A13 CYP2B6 ABCB5

1.55e-06181114CID000054088
Drugdebrisoquine

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11 LRRK2

1.79e-06751116CID000002965
DrugD 617

CYP2A6 CYP2A13 CYP2B6 ABCB5

1.96e-06191114CID000093168
Drugchloral hydrate

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11 CHN2 MSLN

3.31e-061291117CID000002707
Drug19-HETE

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

4.04e-06491115CID006439528
Drug14(15)-EpETrE

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11 GNAQ

4.90e-06891116CID000001431
Drugnicotine glucuronide

ABCC3 CYP2A6 ABCB5

6.20e-0681113CID003035848
Drugtienilic acid

ABCC3 CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

6.33e-06931116CID000038409
DrugBP-9,10-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

8.61e-06271114CID000037456
DrugBrn 4136738

CYP2A6 CYP2A7 CYP2A13 CYP2B6

8.61e-06271114CID000050331
DrugC14845

CYP2A6 CYP2A7 CYP2A13 CYP2B6

8.61e-06271114CID011954064
DrugAC1L1KIN

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11 ABCB5

9.63e-061001116CID000005516
Drugnorverapamil

CYP2A6 CYP2A13 CYP2B6 ABCB5

1.00e-05281114CID000104972
Drug9-OH-BaP-4,5-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.00e-05281114CID000115064
DrugMenthol

ABCC3 CYP2A6 CYP2A13 CYP2B6

1.00e-05281114ctd:D008610
Drug5-OH-VPA

CYP2A6 CYP2B6 CYP4A11

1.32e-05101113CID000135243
Drug4-OH-VPA

CYP2A6 CYP2B6 CYP4A11

1.32e-05101113CID000134466
Drug19-hydroxytestosterone

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.33e-05301114CID000150968
Drug11-H-14,15-EETA

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.33e-05301114CID011954058
Drugchlorzoxazone

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

1.41e-05631115CID000002733
DrugBP-7,8-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.73e-05321114CID000037455
DrugD-702

CYP2A6 CYP2A13 CYP2B6

1.81e-05111113CID000054077
Drugpiperonyl butoxide

ABCC3 CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.91e-05671115CID000005794
Drugpropoxyphene

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

1.91e-05671115CID000010100
Drugrifampicin

ABCC3 CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11 ABCB5 POLR2B TGM1

1.94e-053061119CID005381226
Drug5,6-epoxyeicosatrienoic acid

CYP2A6 CYP2A7 CYP2A13 CYP2B6 GNAQ

2.05e-05681115CID000001778
Drug8(9)-EET

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

2.21e-05691115CID000001901
Drug12(13)-EpOME

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.22e-05341114CID000001416
DrugTCEO

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.22e-05341114CID000028167
DrugAC1O5XSP

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.22e-05341114CID006442739
Drugpropargyl ether

CYP2A6 CYP2A13

2.36e-0521112ctd:C531209
Drugverbenone

CYP2A6 CYP2B6

2.36e-0521112ctd:C052875
DrugHempa

CYP2A6 CYP2A13

2.36e-0521112ctd:D006492
Drugnicotine imine

CYP2A6 CYP2A13

2.36e-0521112ctd:C034629
Drugalpha-nicotyrine

CYP2A6 CYP2A13

2.36e-0521112ctd:C008615
DrugN-nitrosoguvacoline

CYP2A6 CYP2A13

2.36e-0521112ctd:C036676
Drug1h1q

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

2.37e-05701115CID000001540
DrugAC1L1CJI

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.49e-05351114CID000001929
Drugcarteolol

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

2.71e-05721115CID000002583
Drug15-H-11,12-EETA

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.79e-05361114CID011954042
DrugAC1L3NGJ

CYP2A6 CYP2A7 CYP2A13 CYP2B6

2.79e-05361114CID000092121
Drug7-hydroxyquinoline

CYP2A6 CYP2B6 CYP4A11

3.11e-05131113CID000011378
DrugPhIP-HCl

ABCC3 CYP2A6 CYP2A13 CYP2B6 ABCB5 PCNA

3.13e-051231116CID000001530
Drughexobarbital

CYP2A6 CYP2A7 CYP2A13 CYP2B6 NAA15 CYP4A11

3.75e-051271116CID000003608
Drug11,14,15-THET

CYP2A6 CYP2A7 CYP2A13 CYP2B6

3.86e-05391114CID006439531
Drug7-BFC

CYP2A6 CYP2B6 CYP4A11

3.95e-05141113CID000848780
DrugN-nitrosomethylaniline

CYP2A6 CYP2A7 CYP2A13

3.95e-05141113CID000011957
Drugtrimipramine

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

4.52e-05801115CID000005584
Drugfurafylline

KNTC1 CYP2A6 CYP2B6 CYP4A11

4.71e-05411114CID000003433
DrugAC1L7SPV

CYP2A6 CYP2B6 CYP4A11

4.92e-05151113CID000366354
DrugN'-nitrosonornicotine

CYP2A6 CYP2A13 PCNA

4.92e-05151113ctd:C008655
DrugTolbutamide [64-77-7]; Down 200; 14.8uM; MCF7; HT_HG-U133A

SOX4 ABCC3 STAB2 PER2 PLCG1 MMP17 SOS2

5.19e-0519711173886_DN
Drug11,12,15-trihydroxyeicosatrienoic acid

CYP2A6 CYP2A7 CYP2A13 CYP2B6

5.19e-05421114CID006439610
Drugdelavirdine

KNTC1 ABCC3 CYP2B6 ABCB5

5.19e-05421114CID000005625
Drugaminoglutethimide

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11 CD226

5.74e-051371116CID000002145
Drugdiosmetin

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

6.05e-05851115CID005281612
Drugpolybrominated biphenyl

CYP2A6 CYP2A7 CYP2A13 CYP2B6

6.25e-05441114CID000042948
Drugnaphthalene-1,2-dihydrodiol

CYP2A6 CYP2A7 CYP2A13 CYP2B6

6.83e-05451114CID000000362
Drug5-hydroxyvalproate

CYP2A6 CYP2B6

7.04e-0531112ctd:C091208
Drug4-hydroxyvalproate

CYP2A6 CYP2B6

7.04e-0531112ctd:C091207
Drug2-propyl-4-pentenoic acid

CYP2A6 CYP2B6

7.04e-0531112ctd:C045022
Drug2-hydroxysebacate

ABCD1 MED12

7.04e-0531112CID000128458
Drughexafluoron

CYP2A6 CYP2B6

7.04e-0531112ctd:C058039
Drugmephenytoin

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

7.14e-05881115CID000004060
DrugDMP 266

ABCC3 CYP2A6 CYP2B6 ABCB5

8.12e-05471114CID000003203
DrugC14802

CYP2A6 CYP2A7 CYP2A13 CYP2B6

8.12e-05471114CID011954053
DrugAC1L1R04

KNTC1 CYP2A6 CYP2B6 CYP4A11

8.12e-05471114CID000008439
Drugparathion

CYP2A6 CYP2A7 CYP2A13 CYP2B6 PCNA

8.38e-05911115CID000000991
Drugnitro-L

CYP2A6 CYP2A7 CYP2A13 CYP2B6

8.82e-05481114CID000006849
DrugC14800

CYP2A6 CYP2A7 CYP2A13 CYP2B6

8.82e-05481114CID011954051
DrugEthylnitrosourea

NCKAP1 POMT1 CRYGB GNAQ HECTD1 MED12 PCNA HDAC1

9.15e-052911118ctd:D005038
DrugAC1L1BEQ

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

9.29e-05931115CID000001407
Druglansoprazole

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

9.29e-05931115CID000003883
Drugbromobenzene-3,4-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

9.57e-05491114CID000108121
DrugMicotil

CYP2A6 CYP2B6 CYP4A11 TMOD2 LATS2 CD226

1.02e-041521116CID000017675
Drugbromobenzene-2,3-oxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.04e-04501114CID003036760
Drugxanthate

CYP2B6 RHOJ ACSBG1 PLCG1

1.04e-04501114CID000008823
Drug6-hydroxymelatonin

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.04e-04501114CID000001864
Drug1,1-dichloroethylene epoxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.04e-04501114CID000119521
Drugnaphthalene epoxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.12e-04511114CID000108063
Drugmepivacaine

CYP2A6 CYP2A7 CYP2A13 PRKD1

1.12e-04511114CID000004062
Drugbromobenzene

ABCC3 CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.13e-04971115CID000007961
Drugpropafenone

CYP2A6 CYP2A13 CYP2B6 CYP4A11 ABCB5

1.19e-04981115CID000004932
DrugPCB 77

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

1.19e-04981115CID000036187
DrugN-desmethyl-tamoxifen-hydrochloride

CYP2A6 CYP2B6 ABCB5 PRKD1

1.21e-04521114CID000035887
Drugolivacine

CYP2A6 CYP2B6 ABCB5

1.21e-04201113CID005281407
Drug9-hydroxybenzo(a)pyrene

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.30e-04531114CID000028598
DrugSparteinum

CYP2A6 CYP2A7 CYP2A13 CYP2B6 CYP4A11

1.37e-041011115CID000003966
Drugdichloroacetaldehyde

CYP2A6 CYP2A7 CYP2A13 CYP2B6

1.40e-04541114CID000006576
Drugtaxinine K

ABCB5 BTK

1.40e-0441112CID005321708
Drug5-hydroxycoumarin

CYP2A6 CYP2B6

1.40e-0441112CID005318179
Drugestragole

CYP2A6 PCNA

1.40e-0441112ctd:C007633
DrugN'-nitrosoanatabine

CYP2A6 CYP2A13

1.40e-0441112ctd:C032978
Drugchlorfluazuron

CYP2A6 CYP2B6

1.40e-0441112ctd:C057223
DrugNMPA

CYP2A6 CYP2A13

1.40e-0441112CID000132101
Drugcarbon monoxide

CYP2A6 CYP2A7 CYP2A13 CYP2B6 RHOJ CYP4A11 PER2

1.48e-042331117CID000000281
Drugphenacetin

CYP2A6 CYP2A13 CYP2B6 CYP4A11

1.51e-04551114CID000004754
Diseasenicotine metabolite ratio

CYP2A6 CYP2A7 CYP2B6

9.96e-06121073EFO_0007794
DiseaseAnorectal Malformations

SOX4 INTU MPRIP MED12

1.49e-05411074C3495676
DiseaseCobblestone Lissencephaly

POMT1 TMTC3

3.90e-0531072C0431376
Diseasecaffeine metabolite measurement

CYP2A6 CYP2A7 CYP2B6

4.31e-05191073EFO_0007872
DiseaseMental Retardation, X-Linked 1

IL1RAPL1 ACSL4 MED12

2.13e-04321073C2931498
Diseaseadrenoleukodystrophy (implicated_via_orthology)

ACSBG1 ABCD1

2.70e-0471072DOID:10588 (implicated_via_orthology)
DiseaseMalignant neoplasm of salivary gland

SOX4 SOX11 PRKD1

5.89e-04451073C0220636
DiseaseSalivary Gland Neoplasms

SOX4 SOX11 PRKD1

6.69e-04471073C0036095
DiseaseTOBACCO ADDICTION, SUSCEPTIBILITY TO (finding)

CYP2A6 CYP2B6

8.40e-04121072C1861063
DiseaseCarcinoma, Granular Cell

CYP2A6 PRKD1 PCNA MSLN

8.57e-041161074C0205644
DiseaseAdenocarcinoma, Tubular

CYP2A6 PRKD1 PCNA MSLN

8.57e-041161074C0205645
DiseaseAdenocarcinoma, Oxyphilic

CYP2A6 PRKD1 PCNA MSLN

8.57e-041161074C0205642
DiseaseCarcinoma, Cribriform

CYP2A6 PRKD1 PCNA MSLN

8.57e-041161074C0205643
DiseaseAdenocarcinoma, Basal Cell

CYP2A6 PRKD1 PCNA MSLN

8.57e-041161074C0205641
DiseaseAdenocarcinoma

CYP2A6 PRKD1 PCNA MSLN

8.57e-041161074C0001418
DiseaseCoffin-Siris syndrome

SOX4 SOX11

9.90e-04131072C0265338
DiseaseOsteogenesis Imperfecta

TENT5A CRTAP

9.90e-04131072C0029434
Diseasemosquito bite reaction itch intensity measurement, mosquito bite reaction size measurement

CEL CHN2 IL1RAPL1 CHSY3 GNAQ PTPN20

1.27e-033281076EFO_0008377, EFO_0008378
Diseaseresponse to platinum based chemotherapy, magnesium measurement

OTUD4 PRKD1

1.33e-03151072EFO_0004647, EFO_0004845
Diseasepancreatic ductal carcinoma (is_marker_for)

MEN1 MSLN HDAC1

1.43e-03611073DOID:3587 (is_marker_for)
DiseaseHETE measurement

FAM91A1 NBAS CD226

1.50e-03621073EFO_0801166
Diseasepancreatic ductal carcinoma (is_implicated_in)

MEN1 MSLN

1.51e-03161072DOID:3587 (is_implicated_in)
Diseasebreast carcinoma (is_marker_for)

SOX4 PLCG1 HDAC1

1.80e-03661073DOID:3459 (is_marker_for)
DiseaseAdrenocortical carcinoma

MEN1 MED12

1.92e-03181072C0206686
DiseaseNonorganic psychosis

ST6GALNAC1 CYP2B6 MED12

2.04e-03691073C0349204
Diseasecolorectal cancer (is_marker_for)

LATS2 BTK PLCG1 HDAC1

2.60e-031571074DOID:9256 (is_marker_for)
DiseaseOsteogenesis imperfecta

TENT5A CRTAP

2.62e-03211072cv:C0029434
DiseaseMalignant tumor of colon

RHOJ ACTG2 PTPRJ PCNA

2.72e-031591074C0007102
DiseaseColorectal Neoplasms

ABCC3 CYP2A6 ABCB5 CD226 PRKD1

3.43e-032771075C0009404

Protein segments in the cluster

PeptideGeneStartEntry
SKLMPYYLFHRSRGV

nan

71

Q6ZS49
LRNHYLKDIERMYGG

ACSL4

696

O60488
SPLILYYLKMHELAG

FAM227B

391

Q96M60
TLRYGFLLMLKYPHV

CYP2B6

306

P20813
FLLMLKYPHVAERVY

CYP2B6

311

P20813
RYGFLLLMKHPEVEA

CYP2A6

311

P11509
LYRPHLASEKVYTIM

BTK

616

Q06187
HLDRTMYLLGYIPKD

COPB2

556

P35606
HAELMAKRGLYYSLV

ABCB5

606

Q2M3G0
HYDILKPYVGLMADS

CYP4A11

151

Q02928
IYEGYALPHAIMRLD

ACTG2

166

P63267
LNLRPHDIAYLLIYM

ADAM32

266

Q8TC27
AIYYHIKNRDPDGRM

CCNY

126

Q8ND76
KVPLAGLEYPMLHYV

CEL

291

P19835
DATPMDAYLRKLGLY

OTUD4

21

Q01804
IRAMDTLKIPYKYEH

GNAQ

91

P50148
MAIYGYRHPLEEKDL

ABCC3

226

O15438
GEYMEKLSRLAYHPL

NIBAN2

386

Q96TA1
LLYDLGHLERYPMAL

MEN1

271

O00255
ARMFYHRPKYALLDE

ABCD1

616

P33897
GLDILSPMERFHLKY

EXO5

66

Q9H790
SPMERFHLKYLYVTD

EXO5

71

Q9H790
PDYLMKILTEHGYRF

POTEF

886

A5A3E0
DVYGIVYDLRMHRPL

PTPRJ

1266

Q12913
RLHSPMYYLLRGLSV

OR1B1

56

Q8NGR6
GLIYLDSRLHTPMYV

OR2A12

46

Q8NGT7
GMYDKILLFRHDPTS

PRKD1

96

Q15139
LYEHGLLRYALDEMP

MPRIP

76

Q6WCQ1
SHKAPAFLYDIYLRM

FAR1

356

Q8WVX9
FLGLMPYYKDHLERI

KCTD7

156

Q96MP8
YDGMEHLIYGEPRKL

MAGEA10

256

P43363
SLYLMLDRGHLDYPR

MAN2A1

21

Q16706
SLSIDRYHAIVYPMK

NPSR1

141

Q6W5P4
GLYRKMEIYRPHKAN

HDAC1

46

Q13547
LVLDPYLGFRTHKMN

KMT5C

21

Q86Y97
AALEYISKMGYLDPR

LATS2

131

Q9NRM7
TYMPYLHKALLRRGI

GLB1L3

236

Q8NCI6
ELLKYSRDHLMLYPY

FAM91A1

66

Q658Y4
QYMGHYLIRDERKDP

DDX60

741

Q8IY21
YHPFRMTPYLVKVRD

PER2

286

O15055
IADMGHLKYYLAPKI

PCNA

241

P12004
HRGSALPLAIKYMFD

PLXNA1

1706

Q9UIW2
HRGSALPLAIKYMFD

PLXNA3

1681

P51805
LEILPDMLEKHYGYK

IL1RAPL1

431

Q9NZN1
PMYYFLKHLSLLDLC

OR14J1

56

Q9UGF5
LGLMAYDRYVAISHP

OR2V2

116

Q96R30
GRYLEHLEVKFMNPY

FBXO39

86

Q8N4B4
GLRYLHSAMIIYRDL

LRRK2

1981

Q5S007
SGILHKLDPYDYEMI

KNTC1

1516

P50748
MAAFGILSYEHRPLK

MED12

1

Q93074
HLGYLFLKMSPEDIR

MSLN

371

Q13421
DRYLAIAKPLHYVTM

OR4D6

121

Q8NGJ1
MKYFDRLHPGDLITV

NBAS

1881

A2RRP1
RLLYMKEKPLTYEHG

RHOJ

146

Q9H4E5
SLPHRLSAAKMVYYL

NAA15

761

Q9BXJ9
VDFCGKYRLPLMHYL

LRRC58

316

Q96CX6
YMEELRAHVRKYGPV

NCKAP1

411

Q9Y2A7
FLLYPELMSRYGHRV

MEI1

786

Q5TIA1
EGRYFLLVVGLKHYM

INTU

586

Q9ULD6
DRYIAISKPLHYMTI

OR4D9

121

Q8NGE8
YIRYARKSHLTGPMV

PTPN20

336

Q4JDL3
LMEKTLFLYHYLPAL

POMT1

656

Q9Y6A1
EEYSKKPLILVYMRH

OTUD6B

256

Q8N6M0
KPLILVYMRHAYGLG

OTUD6B

261

Q8N6M0
VLMLLPPAHYETLRY

CHN2

391

P52757
HYLKLPEYSSEEIMR

HECTD1

2581

Q9ULT8
RYGFLLLMKHPEVEA

CYP2A13

311

Q16696
PRHFAAKLDKYMYIL

B4GALT6

246

Q9UBX8
RSDVRLYGMIYKPHA

DPP9

616

Q86TI2
RYGFLLLMKHPEVEA

CYP2A7

311

P20853
LMPLESAYRHALDKY

CRTAP

41

O75718
NTLLYILHYDIDGPM

ITGAV

836

P06756
IYELTVLKDPYTGMH

CELF5

71

Q8N6W0
LPYTVHRMFYEALDK

ACSBG1

101

Q96GR2
LIPPHSGAYRMKIYD

CRYGB

81

P07316
GHYYDASKRMPQELI

ELP4

181

Q96EB1
MDYPTLLLALLHVYR

CD226

1

Q15762
ILLGEYHAALPMLIY

SLC22A13

471

Q9Y226
EGDMPIHELLSLYGY

MIER1

61

Q8N108
MLYPLSHGFRKAIAE

OGT

511

O15294
ALMAPYYKRLGRDAL

MMP28

256

Q9H239
RLKHMADYPDYKYRP

SOX11

106

P35716
RLKHMADYPDYKYRP

SOX4

116

Q06945
KLIERLTYHMYADPN

SOS2

606

Q07890
LPLQELAMRGLYHTY

LRRC28

271

Q86X40
LGHDTVRALMYYALK

MMP17

151

Q9ULZ9
HSYLRYLKPKDTSMG

RNF113B

151

Q8IZP6
LRYLISYGKHTLDML

PLCL2

246

Q9UPR0
LLSISDHYGRKFPMI

SLC46A3

91

Q7Z3Q1
KAYFLGYMVHRLLLA

POLR2B

361

P30876
DRYLLLHPDFLRYMK

ST6GALNAC1

486

Q9NSC7
APLHYYETVRMAAIK

ST3GAL3

331

Q11203
YELEMYEKGLSARPH

MTG2

326

Q9H4K7
EEMYKLYPNARRAHL

SPG21

236

Q9NZD8
PMHGVEYILDLLLLY

CHSY3

531

Q70JA7
HYEYRHVMLPRELSK

CKS2

16

P33552
LARLHYIMGDYAEAL

CLUH

1026

O75153
RVYLGALKYMPHAVL

PRPF8

86

Q6P2Q9
EGHRYYAPLLDAMVR

SNX20

261

Q7Z614
RKAHGMLKLYYGLSE

VPS51

31

Q9UID3
YMELRGYPLRAFKLA

ZSWIM5

1006

Q9P217
LMLLHIKYLYGIRVE

AGPAT1

71

Q99943
LLDMLGYRNHYKVTA

TTC41P

626

Q6P2S7
DLISYYEKHPLYRKM

PLCG1

736

P19174
IPALIKYHMLLGTYR

STAB2

1056

Q8WWQ8
KYHMLLGTYRVADLQ

STAB2

1061

Q8WWQ8
SHVKEPRYLLMGGRY

ZNFX1

541

Q9P2E3
MREDITYLYKHPEGS

TGM1

536

P22735
NYLLSELKPMSYHLL

TMTC3

81

Q6ZXV5
AYLPSKRNHMLLLYP

WDR11

251

Q9BZH6
GLEDRKYEYLMTLHG

TENT5A

346

Q96IP4
TGPFDREHLLMYLEK

TMOD2

61

Q9NZR1
LEHYRDMGYPLAVKL

USP13

246

Q92995
YPLHAIMEIKEYLID

WFS1

291

O76024
YMEHRGLPLRAYKLA

ZSWIM4

811

Q9H7M6
VLVRHLGYKPEEYKM

MYO1C

696

O00159