Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnodal binding

LEFTY2 LEFTY1 WIF1

6.31e-068983GO:0038100
GeneOntologyBiologicalProcessnegative regulation of nodal receptor complex assembly

LEFTY2 LEFTY1

2.14e-052962GO:1900124
GeneOntologyBiologicalProcessregulation of nodal receptor complex assembly

LEFTY2 LEFTY1

2.14e-052962GO:1900123
GeneOntologyBiologicalProcessnodal receptor complex assembly

LEFTY2 LEFTY1

2.14e-052962GO:0038099
MousePhenoabnormal left renal vein morphology

LEFTY2 LEFTY1

2.69e-052732MP:0011327
MousePhenoabnormal renal vein morphology

LEFTY2 LEFTY1

2.69e-052732MP:0011323
DomainPAS

NCOA3 KCNH7 PDE8A PDE8B

2.11e-0532964SM00091
DomainLRDF

LEFTY2 LEFTY1

2.61e-052962IPR003942
DomainPDEase_PDE8

PDE8A PDE8B

2.61e-052962IPR013938
DomainPAS

NCOA3 KCNH7 PDE8A PDE8B

2.70e-0534964IPR000014
DomainPAS

NCOA3 KCNH7 PDE8A PDE8B

2.70e-0534964PS50112
DomainPAS

NCOA3 PDE8A PDE8B

2.79e-0425963PF00989
DomainPAS_fold

NCOA3 PDE8A PDE8B

2.79e-0425963IPR013767
DomainPAS_9

KCNH7 PDE8B

1.15e-0310962PF13426
DomainMyosin_N

MYO5C MYH14

2.63e-0315962PF02736
DomainMyosin_N

MYO5C MYH14

2.63e-0315962IPR004009
DomainPDEase

PDE8A PDE8B

4.22e-0319962IPR023088
DomainMyosin-like_IQ_dom

MYO5C MYH14

4.22e-0319962IPR027401
Domain-

MYO5C MYH14

4.22e-03199624.10.270.10
DomainPDEase_I

PDE8A PDE8B

5.15e-0321962PF00233
DomainPDEASE_I

PDE8A PDE8B

5.15e-0321962PS00126
DomainPDEase_CS

PDE8A PDE8B

5.15e-0321962IPR023174
Domain-

PDE8A PDE8B

5.65e-03229621.10.1300.10
DomainPDEase_catalytic_dom

PDE8A PDE8B

6.17e-0323962IPR002073
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS

PPP1R13L AKT1 AKT2

4.10e-0514703MM15341
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS

PPP1R13L AKT1 AKT2

4.10e-0514703M27638
PathwayKEGG_MEDICUS_VARIANT_LOSS_OF_NKX3_1_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

2.41e-045702M48999
PathwayWP_GROWTH_FACTORS_AND_HORMONES_IN_BETA_CELL_PROLIFERATION

FOXM1 AKT1 AKT2

2.81e-0426703M48092
PathwayKEGG_MEDICUS_REFERENCE_MAGI_PTEN_SIGNALING_PATHWAY

AKT1 AKT2

3.60e-046702M47523
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PI3K_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

5.02e-047702M47407
PathwayKEGG_MEDICUS_REFERENCE_ACH_CHRN_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

5.02e-047702M47790
PathwayWP_JAKSTAT_SIGNALING_IN_THE_REGULATION_OF_BETA_CELLS

FOXM1 AKT1 AKT2

6.28e-0434703M48081
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.68e-048702M47399
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.68e-048702M47394
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.68e-048702M47395
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.68e-048702M47404
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.68e-048702M47405
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.68e-048702M47803
PathwayREACTOME_RUNX2_REGULATES_GENES_INVOLVED_IN_CELL_MIGRATION

AKT1 AKT2

6.68e-048702M27806
PathwayKEGG_MEDICUS_VARIANT_TGFA_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.68e-048702M47482
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.68e-048702M47498
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_RET_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.68e-048702M47715
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

8.56e-049702M47397
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

8.56e-049702M47392
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

8.56e-049702M47391
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

8.56e-049702M47402
PathwayKEGG_MEDICUS_REFERENCE_MEMBRANE_INITIATED_PROGESTERONE_SIGNALING_PATHWAY

AKT1 AKT2

8.56e-049702M47802
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_MET_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

8.56e-049702M47490
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

8.56e-049702M47481
PathwayREACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING

AKT1 AKT2

8.56e-049702MM15666
PathwayKEGG_MEDICUS_REFERENCE_ICOSLG_ICOS_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

8.56e-049702M47972
PathwayKEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.07e-0310702M47400
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.07e-0310702M47401
PathwayKEGG_MEDICUS_REFERENCE_CD80_CD86_CD28_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.07e-0310702M47615
PathwayREACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS

AKT1 AKT2

1.07e-0310702M27095
PathwayREACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS

AKT1 AKT2

1.07e-0310702MM14778
PathwayKEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.30e-0311702M47797
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.30e-0311702M47403
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.30e-0311702M47406
PathwayKEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.30e-0311702M47484
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.30e-0311702M47499
PathwayKEGG_MEDICUS_REFERENCE_NRG_ERBB4_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.30e-0311702M47756
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339

AKT1 AKT2

1.30e-0311702M47791
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.30e-0311702M47501
PathwayWP_MIR127_IN_MESENDODERM_DIFFERENTIATION

LEFTY2 LEFTY1

1.55e-0312702MM15910
PathwayKEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.55e-0312702M47393
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01350

AKT1 AKT2

1.55e-0312702M47798
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY

AKT1 AKT2

1.55e-0312702M47558
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY

AKT1 AKT2

1.55e-0312702M47559
PathwayREACTOME_REGULATION_OF_SIGNALING_BY_NODAL

LEFTY2 LEFTY1

1.55e-0312702M26952
PathwayREACTOME_SARS_COV_2_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS

AKT1 AKT2

1.55e-0312702M45022
PathwayREACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS

AKT1 AKT2

1.55e-0312702MM15657
PathwayREACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS

AKT1 AKT2

1.55e-0312702M27939
PathwayREACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL

AKT1 AKT2

1.55e-0312702MM14777
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING

AKT1 AKT2

1.55e-0312702MM14550
PathwayPID_HEDGEHOG_GLI_PATHWAY

IFT172 GLI3 AKT1

1.73e-0348703M219
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.83e-0313702M47398
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.83e-0313702M47603
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING

AKT1 AKT2

1.83e-0313702M549
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

2.13e-0314702M47390
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY

AKT1 AKT2

2.13e-0314702M47467
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY

AKT1 AKT2

2.13e-0314702M47536
PathwayREACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL

AKT1 AKT2

2.13e-0314702M3862
PathwayKEGG_ENDOMETRIAL_CANCER

APC2 AKT1 AKT2

2.18e-0352703M19877
PathwayKEGG_NON_SMALL_CELL_LUNG_CANCER

STK4 AKT1 AKT2

2.43e-0354703M19818
PathwayWP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER

SEMA3A AKT1 AKT2

2.43e-0354703M42568
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

2.45e-0315702M47389
PathwayKEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

2.45e-0315702M47663
PathwayREACTOME_ACTIVATION_OF_BAD_AND_TRANSLOCATION_TO_MITOCHONDRIA

AKT1 AKT2

2.45e-0315702M26902
PathwayWP_TRANSCRIPTION_FACTORS_REGULATE_MIRNAS_RELATED_TO_CARDIAC_HYPERTROPHY

AKT1 AKT2

2.45e-0315702M39431
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

2.45e-0315702M47475
PathwayWP_RIOK1_AND_RIOK2_IN_EGFR_AND_PI3KMEDIATED_TUMORIGENESIS

AKT1 AKT2

2.45e-0315702M48306
PathwayKEGG_MEDICUS_REFERENCE_BCR_BCAP_CD19_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

2.45e-0315702M47971
PathwayWP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION

ADCY4 PDE8A PDE8B

2.56e-0355703M39763
PathwayREACTOME_POLO_LIKE_KINASE_MEDIATED_EVENTS

FOXM1 LIN9

2.79e-0316702M26971
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

USP34 ZNF609 EP400 RADX UGGT1 MPDZ PPP1R13L LARP4 ARID3B STK4 ATAD1 ARHGEF10 CEBPZ AKT2 CEP295 QSER1

2.87e-10733991634672954
Pubmed

Human transcription factor protein interaction networks.

NCOA3 ACTR8 ZNF609 EP400 RADX NUMA1 LARP4 TRIM24 LIN9 MYO5C DHX30 ARID3B DDX10 MED15 PAX8 MYH14 GLI3 TAF1 EIF3F QSER1 CNOT1

5.03e-101429992135140242
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

USP34 FLNC UGGT1 NUMA1 LARP4 DHX30 DDX10 TTLL12 TGM3 MYH14 CEBPZ BYSL CNOT1 NUP153

5.16e-09653991422586326
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

NCOA3 ZNF609 EP400 MED14 TRIM24 LIN9 ARID3B MED15 TAF1 QSER1

5.32e-09268991033640491
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

FOXM1 FLNC ZNF609 EP400 PPP1R13L LARP4 TRIM24 ARID3B MED15 MYH14 EIF3F

5.97e-08444991134795231
Pubmed

Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis.

HORMAD1 LEFTY2 LEFTY1 GLI3

2.32e-071999429941866
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

RADX RNPC3 NUMA1 MED14 RPS18 LARP4 DHX30 ARID3B DDX10 CEBPZ BYSL METTL17 CNOT1

2.54e-07759991335915203
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

NCOA3 ZNF609 PDE8A RADX IFT172 FAM117B PPP1R13L DHX30 ARID3B MED15 STK4 EAF1 ATAD1 GLI3 QSER1 CNOT1

9.96e-071321991627173435
Pubmed

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

ZNF609 RADX RNPC3 UGGT1 DDX10 STK4 ATAD1 MYH14 CEBPZ GOLGA7 EIF3F NUP153

1.63e-06754991233060197
Pubmed

Genetic interaction mapping in mammalian cells using CRISPR interference.

ACTR8 EP400 MED14 MED15 CNOT1

1.64e-066999528481362
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

DOCK1 UGGT1 NUMA1 MYO5C DHX30 MYH14 CNOT1

1.90e-0620299733005030
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

USP34 ACTR8 IFT172 APC2 NBEA SEC31B TUBGCP5 DHX30 TTLL12 NSMF ARHGEF10 MYH14 WIF1 TAF1 EIF3F

3.53e-061285991535914814
Pubmed

The SIL gene is required for mouse embryonic axial development and left-right specification.

LEFTY2 LEFTY1 GLI3

3.63e-061199310385121
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

EP400 NUMA1 MED14 MPDZ ARID3B MED15 CEBPZ TAF1 QSER1 CNOT1

3.92e-06549991038280479
Pubmed

Ftm is a novel basal body protein of cilia involved in Shh signalling.

LEFTY2 LEFTY1 GLI3

6.27e-061399317553904
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

USP34 NCOA3 ZNF609 LARP4 TRIM24 MED15 QSER1 CNOT1 NUP153

6.57e-0645799932344865
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

FLNC EP400 UGGT1 NUMA1 RPS18 MYO5C DHX30 DDX10 RPAP1 MYH14 CEBPZ CNOT1 NUP153

6.91e-061024991324711643
Pubmed

Interaction network of human early embryonic transcription factors.

NCOA3 ZNF609 EP400 TRIM24 LIN9 MED15 TAF1 QSER1

7.66e-0635199838297188
Pubmed

Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia.

IFT172 LEFTY2 LEFTY1

7.96e-061499322554696
Pubmed

Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells.

AKT1 AKT2

8.02e-06299227878243
Pubmed

cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis.

PDE8A PDE8B

8.02e-06299222232524
Pubmed

BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.

AKT1 AKT2

8.02e-06299227699769
Pubmed

Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma.

AKT1 AKT2

8.02e-06299231252679
Pubmed

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage.

AKT1 AKT2

8.02e-06299219622728
Pubmed

Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients.

AKT1 AKT2

8.02e-06299228271235
Pubmed

LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.

LEFTY2 LEFTY1

8.02e-06299232745796
Pubmed

Role of Akt in cardiac growth and metabolism.

AKT1 AKT2

8.02e-06299217019809
Pubmed

Knockout of Akt1/2 suppresses the metastasis of human prostate cancer cells CWR22rv1 in vitro and in vivo.

AKT1 AKT2

8.02e-06299233377281
Pubmed

Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin.

AKT1 AKT2

8.02e-0629929620559
Pubmed

The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland.

PDE8A PDE8B

8.02e-06299221187369
Pubmed

Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts.

AKT1 AKT2

8.02e-06299211861503
Pubmed

Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation.

AKT1 AKT2

8.02e-06299212808085
Pubmed

Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes.

AKT1 AKT2

8.02e-06299215010337
Pubmed

Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.

AKT1 AKT2

8.02e-06299236229454
Pubmed

Akt2 regulates cardiac metabolism and cardiomyocyte survival.

AKT1 AKT2

8.02e-06299216950770
Pubmed

Akt isoforms differentially regulate neutrophil functions.

AKT1 AKT2

8.02e-06299220332370
Pubmed

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

AKT1 AKT2

8.02e-0629923037531
Pubmed

High-intensity muscle contraction-mediated increases in Akt1 and Akt2 phosphorylation do not contribute to mTORC1 activation and muscle protein synthesis.

AKT1 AKT2

8.02e-06299232078465
Pubmed

LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.

LEFTY2 LEFTY1

8.02e-06299220056823
Pubmed

Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.

LEFTY2 LEFTY1

8.02e-06299210053005
Pubmed

Defining Akt actions in muscle differentiation.

AKT1 AKT2

8.02e-06299223076793
Pubmed

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.

AKT1 AKT2

8.02e-06299219110052
Pubmed

Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice.

AKT1 AKT2

8.02e-06299223919516
Pubmed

Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors.

AKT1 AKT2

8.02e-06299217804734
Pubmed

Lack of AKT in adipocytes causes severe lipodystrophy.

AKT1 AKT2

8.02e-06299227408773
Pubmed

Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.

AKT1 AKT2

8.02e-06299217141631
Pubmed

Mutation analysis of human LEFTY A and LEFTY B genes in children with Ivemark syndrome.

LEFTY2 LEFTY1

8.02e-06299211100524
Pubmed

PI3K/AKT Signaling in Breast Cancer Molecular Subtyping and Lymph Node Involvement.

AKT1 AKT2

8.02e-06299231781306
Pubmed

Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells.

AKT1 AKT2

8.02e-06299230692211
Pubmed

Distinct actions of akt1 on skeletal architecture and function.

AKT1 AKT2

8.02e-06299224663486
Pubmed

Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.

AKT1 AKT2

8.02e-06299219491266
Pubmed

Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

AKT1 AKT2

8.02e-06299217609365
Pubmed

Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion.

AKT1 AKT2

8.02e-06299217825284
Pubmed

Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.

LEFTY2 LEFTY1

8.02e-06299224147624
Pubmed

Depletion of Akt1 and Akt2 Impairs the Repair of Radiation-Induced DNA Double Strand Breaks via Homologous Recombination.

AKT1 AKT2

8.02e-06299231847370
Pubmed

Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.

AKT1 AKT2

8.02e-06299226654940
Pubmed

Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions.

AKT1 AKT2

8.02e-06299216923802
Pubmed

Role of AMPK and Akt in triple negative breast cancer lung colonization.

AKT1 AKT2

8.02e-06299233839456
Pubmed

Akt1 and Akt2: differentiating the aktion.

AKT1 AKT2

8.02e-06299221432781
Pubmed

Molecular alterations in AKT and its protein activation in human lung carcinomas.

AKT1 AKT2

8.02e-06299222748472
Pubmed

Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.

AKT1 AKT2

8.02e-06299217045205
Pubmed

Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans.

PDE8A PDE8B

8.02e-06299212681444
Pubmed

Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease.

AKT1 AKT2

8.02e-06299231671832
Pubmed

PKB signaling and atrogene expression in skeletal muscle of aged mice.

AKT1 AKT2

8.02e-06299221551011
Pubmed

Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions.

AKT1 AKT2

8.02e-06299224769357
Pubmed

cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor.

PDE8A PDE8B

8.02e-06299236277728
Pubmed

Distinct and specific roles of AKT1 and AKT2 in androgen-sensitive and androgen-independent prostate cancer cells.

AKT1 AKT2

8.02e-06299223567263
Pubmed

Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells.

LEFTY2 LEFTY1

8.02e-06299220171171
Pubmed

Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily.

LEFTY2 LEFTY1

8.02e-0629929496783
Pubmed

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.

AKT1 AKT2

8.02e-06299216365168
Pubmed

A functional role of LEFTY during progesterone therapy for endometrial carcinoma.

LEFTY2 LEFTY1

8.02e-06299229268772
Pubmed

Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma.

AKT1 AKT2

8.02e-06299215102693
Pubmed

AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes.

AKT1 AKT2

8.02e-06299225162660
Pubmed

The Akt1 isoform is an essential mediator of ischaemic preconditioning.

AKT1 AKT2

8.02e-06299222117619
Pubmed

Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation.

AKT1 AKT2

8.02e-06299219142853
Pubmed

Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors.

AKT1 AKT2

8.02e-06299215545269
Pubmed

Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo.

AKT1 AKT2

8.02e-06299222275470
Pubmed

Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets.

AKT1 AKT2

8.02e-06299226318486
Pubmed

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.

AKT1 AKT2

8.02e-06299225136137
Pubmed

The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.

STK4 AKT1

8.02e-06299217932490
Pubmed

Differential function of Akt1 and Akt2 in human adipocytes.

AKT1 AKT2

8.02e-06299222480544
Pubmed

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.

AKT1 AKT2

8.02e-06299222647600
Pubmed

The PI3K and AIB1 interaction is involved in estrogen treated breast cancer cells.

NCOA3 AKT1

8.02e-06299229808803
Pubmed

Akt isoform-specific inhibition of MDA-MB-231 cell proliferation.

AKT1 AKT2

8.02e-06299220688159
Pubmed

Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium.

AKT1 AKT2

8.02e-06299226971877
Pubmed

Significance of Akt activation and AKT gene increases in soft tissue tumors.

AKT1 AKT2

8.02e-06299224321521
Pubmed

Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.

LEFTY2 LEFTY1

8.02e-06299233409963
Pubmed

LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry.

LEFTY2 LEFTY1

8.02e-06299229230527
Pubmed

Akt as a target for cancer therapy: more is not always better (lessons from studies in mice).

AKT1 AKT2

8.02e-06299228557977
Pubmed

Redundant roles of AKT1 and AKT2 in fertility, estrous cyclicity and endometrial gland development.

AKT1 AKT2

8.02e-06299237053038
Pubmed

Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration.

AKT1 AKT2

8.02e-06299221722267
Pubmed

Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.

LEFTY2 LEFTY1

8.02e-06299217038673
Pubmed

Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response.

AKT1 AKT2

8.02e-06299229025710
Pubmed

Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm.

AKT1 AKT2

8.02e-06299222228739
Pubmed

Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region.

AKT1 AKT2

8.02e-06299233253205
Pubmed

Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis.

AKT1 AKT2

8.02e-06299216075056
Pubmed

IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.

AKT1 AKT2

8.02e-06299218042802
Pubmed

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.

AKT1 AKT2

8.02e-06299220354168
Pubmed

The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation.

AKT1 AKT2

8.02e-06299217914025
Pubmed

Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway.

LEFTY2 LEFTY1

8.02e-06299229286065
InteractionNUP35 interactions

USP34 NCOA3 ZNF609 NUMA1 PLEKHA4 LARP4 TRIM24 MED15 WIF1 QSER1 CNOT1 NUP153

8.17e-074249612int:NUP35
InteractionPAX6 interactions

NCOA3 ACTR8 ZNF609 EP400 LARP4 TRIM24 LIN9 ARID3B EAF1 TAF1 QSER1

1.36e-063669611int:PAX6
InteractionHNF1B interactions

NCOA3 ZNF609 EP400 TRIM24 LIN9 ARID3B PAX8 QSER1

3.52e-06190968int:HNF1B
InteractionHECTD1 interactions

RADX RNPC3 NUMA1 MED14 RPS18 LARP4 MYO5C DHX30 ARID3B DDX10 ARHGEF10 CEBPZ BYSL TAF1 SSH2 METTL17 CNOT1

3.62e-069849617int:HECTD1
InteractionAR interactions

USP34 NCOA3 ZNF609 EP400 NUMA1 MED14 TRIM24 LIN9 MYO5C ARID3B TTLL12 MED15 MYH14 GLI3 AKT1 TAF1 QSER1

4.03e-069929617int:AR
InteractionCNOT3 interactions

PLEKHA4 MED14 NBEA FANCD2OS TRIM24 MED15 GLI3 CNOT1

6.62e-06207968int:CNOT3
InteractionSIRT7 interactions

USP34 FLNC UGGT1 NUMA1 LARP4 DHX30 DDX10 TTLL12 TGM3 MYH14 CEBPZ BYSL CNOT1 NUP153

1.12e-057449614int:SIRT7
InteractionFBXW7 interactions

FOXM1 NCOA3 EP400 RNPC3 NUMA1 MED14 RPS18 DHX30 DDX10 MED15 TGM3 RPAP1 ARHGEF10 MYH14 CEBPZ AKT1 EIF3F SSH2

1.50e-0512159618int:FBXW7
InteractionCTDSPL2 interactions

NCOA3 NUMA1 PLEKHA4 MED15 NUP153

2.09e-0570965int:CTDSPL2
InteractionMALRD1 interactions

MALRD1 CEP295

2.25e-052962int:MALRD1
InteractionCRX interactions

NCOA3 ZNF609 EP400 LARP4 TRIM24 LIN9 MED15 QSER1

2.91e-05254968int:CRX
InteractionHNF4A interactions

NCOA3 ZNF609 EP400 MED14 TRIM24 LIN9 ARID3B QSER1

5.10e-05275968int:HNF4A
InteractionSMAD3 interactions

FOXM1 NCOA3 PLEKHA4 TRIM24 MED15 PAX8 GLI3 AKT1 TAF1 NUP153

5.36e-054479610int:SMAD3
InteractionLRRC31 interactions

DOCK1 UGGT1 NUMA1 MYO5C DHX30 MYH14 CNOT1

5.64e-05205967int:LRRC31
InteractionCTDP1 interactions

RADX PLEKHA4 MED14 SYT2 MED15 RPAP1 AKT1

6.00e-05207967int:CTDP1
InteractionTERF2IP interactions

ZNF609 EP400 RADX NUMA1 TRIM24 LIN9 DDX10 RPAP1 AKT1 TAF1 QSER1

6.34e-055529611int:TERF2IP
InteractionKLF15 interactions

NCOA3 ZNF609 EP400 TRIM24 LIN9 DHX30 MED15 QSER1

7.40e-05290968int:KLF15
InteractionTCL1B interactions

MED14 MED15 AKT1 AKT2

8.01e-0548964int:TCL1B
InteractionNR1I3 interactions

NCOA3 MED14 TRIM24 MED15

8.01e-0548964int:NR1I3
InteractionMEN1 interactions

ACTR8 ZNF609 EP400 NUMA1 PLEKHA4 MED14 RPS18 HORMAD1 DHX30 DDX10 MYH14 CEBPZ TAF1 QSER1 NUP153

1.02e-0410299615int:MEN1
InteractionANKRD17 interactions

PLEKHA4 SYT2 LARP4 TRIM24 GLI3 TCEANC2 CNOT1

1.04e-04226967int:ANKRD17
InteractionPML interactions

FOXM1 USP34 FLNC ZNF609 EP400 UGGT1 NUMA1 PLEKHA4 PPP1R13L LARP4 TRIM24 MED15 MYH14 EIF3F

1.31e-049339614int:PML
InteractionLEFTY1 interactions

LEFTY2 LEFTY1

1.34e-044962int:LEFTY1
InteractionLEFTY2 interactions

LEFTY2 LEFTY1

1.34e-044962int:LEFTY2
InteractionEN1 interactions

ZNF609 EP400 DHX30 ARID3B QSER1

1.82e-04110965int:EN1
GeneFamilyAtaxins|Trinucleotide repeat containing

NCOA3 EP400 MED15

8.37e-0525623775
CoexpressionGSE34205_HEALTHY_VS_RSV_INF_INFANT_PBMC_UP

NCOA3 HLA-DPB1 RADX RNPC3 NUMA1 RPS18 AKR1B1

7.46e-06194967M5136
CoexpressionGSE19923_HEB_KO_VS_HEB_AND_E2A_KO_DP_THYMOCYTE_DN

NCOA3 ARID3B NSMF GLI3 GOLGA7 AKT2 TMEM68

9.10e-06200967M7271
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC ADCY4 MPDZ MMRN1 SEMA3A SLC24A1

2.74e-06178986ad3de3e03a401dac64431a541899445262246347
ToppCellwk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KIF6 PDE8A MPDZ TRIM24 WIF1 SLC24A1

3.22e-061839861464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

USP34 MED14 IRAG1 LIN9 CEP295 TAF1

3.54e-0618698603db813598b67b1e08f759758a1c2023396921fa
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC ADCY4 MPDZ MMRN1 SEMA3A SLC24A1

3.54e-0618698620340a5b5cc7f07386498a4ef937d6fbc9e347c4
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNC ADCY4 MPDZ MMRN1 SEMA3A SLC24A1

5.06e-061989865d42f4fda2081ea3e9f62a00e7eea702e0d0be7d
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNC ADCY4 MPDZ MMRN1 SEMA3A SLC24A1

5.06e-0619898699d6a64f3410dae3019161feef20a8f06081a24b
ToppCellEndothelial-B-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

3.31e-05166985c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

UGGT1 APC2 MEFV TGM3 RGL4

3.82e-051719852b7c5a557c4bc5c573211c4d618bdd6766a24916
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

UGGT1 APC2 MEFV TGM3 RGL4

3.82e-05171985dcb15bc54aeea06ef8f07f1134f3ff1e21ac0e4f
ToppCellEndothelial-B-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

3.93e-051729858a527dff06d841a86c7eb04a1dd9630787294da4
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNC MPDZ MMRN1 SEMA3A SLC24A1

4.03e-051739857dc988fc0ba29990567bf1bcdeb3faeeee507eb1
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FOXM1 ADCY4 RPAP1 ATAD1 CEBPZ

4.15e-05174985feed99acd868db61f045e666dbfdcaed91ca1488
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Neuron|GW19 / Sample Type, Dataset, Time_group, and Cell type.

MED14 SYT2 PDE8B TCEANC2 SSH2

4.26e-051759852812ac2ef41d245db544697fb6da1883361c96e8
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADCY4 DDX10 MMRN1 SLC24A1 HCRTR1

4.50e-051779856248c0dcad302de61a66163ee84b3b79096150d7
ToppCell5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

4.62e-051789854b3ea0921bc598ebb9f63780ecdf8ad4349f3666
ToppCellASK454-Endothelial-Lymphatic|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

PLEKHA4 MPDZ MMRN1 SEMA3A SDCBP2

4.75e-05179985fd84a79f76a01c0377dff5b20016b004d369f96f
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

5.00e-05181985e898ecb8d8f2eb2204225b7b0d665cadcd241139
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

UGGT1 SYT2 MEFV TGM3 SSH2

5.13e-05182985dc32f8f6a3b13918eb8e93c018f5823d86344080
ToppCell3'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADCY4 MMRN1 SEMA3A PDE8B SLC24A1

5.13e-0518298582d6f72649c7dd4d64a84a9795edebdef2f285d6
ToppCell(6)_Endothelial-F_(Lymphatics)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

5.41e-0518498503ea613e00b45c81b752c14505a0538d698f551e
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

5.41e-051849851a4297b9d3cc4744bea0408fd5ee7b33ba2a1d78
ToppCell3'-Child09-12-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNC MMRN1 SEMA3A SLC24A1 HCRTR1

5.55e-051859859de1db2ce9e44956b1214daf6e1e161334679c88
ToppCell3'-Child09-12-SmallIntestine-Endothelial-lymphatic_endothelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNC MMRN1 SEMA3A SLC24A1 HCRTR1

5.55e-0518598518f5d9438c76e37988a7d17aa2a080af6bedbfc4
ToppCellEndoth-Lymph|World / shred by cell class for parenchyma

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

5.55e-0518598597a6c4cd00684d4085d36ef32f7dbb99563ed357
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)|343B / Donor, Lineage, Cell class and subclass (all cells)

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

5.69e-051869857a8da2ad140bea3207bd868212cc5e201d586772
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)-|343B / Donor, Lineage, Cell class and subclass (all cells)

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

5.69e-05186985dc394034929c6b10ae0e1c1a028cc3d4ce873298
ToppCelltumor_Lung-Endothelial_cells-Lymphatic_ECs|tumor_Lung / Location, Cell class and cell subclass

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

5.84e-0518798587ecdc5f24aced95a37e653429f0fc493ff4aa3e
ToppCell390C-Endothelial_cells-Endothelial-F_(Lymphatics)|390C / Donor, Lineage, Cell class and subclass (all cells)

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

5.99e-05188985aa69e3f44d506f5ef358a3374ac5160d847c858f
ToppCellEndothelial-B-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

ADCY4 KIF6 MMRN1 SEMA3A SLC24A1

5.99e-05188985ecb74d67314a43b5805b7f2a7bb9ff6c5a60200a
ToppCell390C-Endothelial_cells-Endothelial-F_(Lymphatics)-|390C / Donor, Lineage, Cell class and subclass (all cells)

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

5.99e-051889851f40b959777d18ad88d239df8cca304f062ba04c
ToppCellASK454-Endothelial-Lymphatic|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq

PLEKHA4 SEC31B SEMA3A MYH14 SLC24A1

6.14e-05189985316c857dec9383823e09f966bca62d52d933b141
ToppCellTransplant_Alveoli_and_parenchyma-Endothelial-Lymphatic|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

6.30e-051909858d6ec2fc0af19a5cb16fff34f8b131b71b33d45f
ToppCellnormal_Lung-Endothelial_cells-Lymphatic_ECs|normal_Lung / Location, Cell class and cell subclass

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

6.30e-051909852185db6007404a2b22325f91460dd17635be9bba
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

6.61e-051929852ec132a1740e865e7cc0f82ffd4772d43f7ac086
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

6.61e-051929853792c53b5d4b759573e1c7bb89ef9b654c9cbfcd
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

6.61e-0519298564022a47dccd7966777f6741d1c68e298f37ca9d
ToppCell3'-Distal_airway-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_mature-Lymphatic_EC_mature_L.2.5.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

6.61e-05192985f67a88bd039944d3d7a5a4a9f2e053985075155c
ToppCellLAM-Endothelial-LymEndo|LAM / Condition, Lineage and Cell class

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

6.78e-0519398568eadc91c2d89edd2412e86dfe134dd7c0ef6ee9
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

6.78e-05193985040f6bb42aa41d0921371fdda1cc0912c4fe1930
ToppCell3'-Parenchyma_lung-Endothelial-Lymphatic_EC|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

6.78e-05193985e468287c8b30c56d1de65e8347ade233ba6cf584
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-myofibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

FLNC PLEKHA4 C4orf54 SEMA3A MYH14

6.78e-0519398502dfd1df1e7fc84bfca2b0c95138b5b4408bb5d1
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

6.95e-05194985937ee85ffd50869b60f0f6e91017ab77e8b24c0b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK1 PAX8 MYH14 NCEH1 SSH2

7.12e-05195985938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK1 PAX8 MYH14 NCEH1 SSH2

7.12e-05195985d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FLNC PLEKHA4 MMRN1 SEMA3A SLC24A1

7.12e-05195985fc75f04eb475c8139cc5c35e6be22e73fb2be9e6
ToppCell343B-Endothelial_cells-Endothelial-F_(Lymphatics)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FLNC PLEKHA4 MMRN1 SEMA3A SLC24A1

7.12e-0519598583d45ff5e5bc704448431149fffb2e4c1278f279
ToppCellproximal-Endothelial-Lymphatic|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

7.47e-051979858835961bd734a86063fd854cd2fb7028aefb7a72
ToppCelltumor_Lung-Endothelial_cells-Lymphatic_ECs|Endothelial_cells / Location, Cell class and cell subclass

FLNC PLEKHA4 MMRN1 SEMA3A SLC24A1

7.47e-05197985a05237ee6d31d9eab491dd7007859d6285cf1424
ToppCelldistal-3-Endothelial-Lymphatic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

7.47e-051979859ea0e2ed9c3f97591a06e70570640996580417d5
ToppCellproximal-Endothelial-Lymphatic-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

7.47e-051979858d79e747e344656e2bfc7fe872b4430dca941196
ToppCellproximal-3-Endothelial-Lymphatic|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

7.47e-051979851c64e4eb9bfbaf5d6b4349642858f83a00d4d4c6
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

7.47e-05197985407231542fa1ffd540dcb61435c0575e71f59725
ToppCelldistal-Endothelial-Lymphatic-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

7.47e-051979858f2e19409ebe9a490d5a245fa82c765ed6d77c3e
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

7.83e-051999851587d24b19f5bb64a3b6cc1df87c7c472cf41672
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

7.83e-05199985a9c2041e54899cb8ccc026758647f3ae3ca457dd
ToppCellBiopsy_IPF-Endothelial-Lymphatic_Endothelial_cells|Biopsy_IPF / Sample group, Lineage and Cell type

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

7.83e-05199985483b01f1308eb201a1ff3788fe656c486b6b9e66
ToppCellBiopsy_Other_PF-Endothelial-Lymphatic_Endothelial_cells|Biopsy_Other_PF / Sample group, Lineage and Cell type

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

7.83e-05199985aa80c77fe4f6a141c780c7d8ecfff5d5a1c3b845
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

DOCK1 USP34 ZNF609 NBEA SSH2

7.83e-0519998594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

8.02e-0520098576e90231aa94afc12e618da8ae314c51644acab4
ToppCellKidney-Keratinocytes|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.

TMEM63C TTLL12 MYH14 A2ML1 RGL4

8.02e-0520098541d83faa9f45ee7ea2ab19be8ecc6d2c5ac7fe5d
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

8.02e-05200985e3e80cb16e0d2e24efc16b62316a6da91bf81ea5
ToppCellBronchial-10x5prime-Endothelial-Endothelia_lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

8.02e-05200985c59f262b2b0a7e7dcb2940d1e466f98db6c56625
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

8.02e-05200985b515b2ab0c3f5928dd67f2f227fc932451c272bb
ToppCellBiopsy_Control_(H.)-Endothelial-Lymphatic_Endothelial_cells|Biopsy_Control_(H.) / Sample group, Lineage and Cell type

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

8.02e-052009858cf218887ab030b7625610cb65b595170a17ebec
ToppCellBronchial-10x5prime-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

8.02e-05200985e50ef394e3284a8323bfd60575b262b2be422aea
ToppCellTracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

FLNC ADCY4 MMRN1 SEMA3A SLC24A1

8.02e-0520098535f6c7f2469d12748c27f2a5d4a161ef839b4a07
ToppCellSepsis-Int-URO-Lymphocyte-B-B_intermediate|Int-URO / Disease, condition lineage and cell class

HLA-DPB1 RPS18 LEFTY2 ARHGEF10 P2RY10

8.02e-05200985221dd8d8851c47f2202ba848de3a041b17b1db3f
ToppCellControl-B_naive-9|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SYT2 IRAG1 ARID3B MMRN1

1.58e-0412398436d509eae874733f1a4f8189ad3000136ff6425e
DiseaseColorectal Carcinoma

FLNC APC2 RPAP1 ATAD1 PAX8 GLI3 WIF1 AKT1 SDCBP2

3.48e-04702929C0009402
DiseaseGastrointestinal Stromal Sarcoma

IFT172 GLI3 DISP1

4.31e-0447923C3179349
DiseaseMalignant neoplasm of breast

FOXM1 NCOA3 KIF6 APC2 SPATA18 MED14 DDX10 SEMA3A CUTC AKT1 AKT2

5.14e-0410749211C0006142
DiseaseGastrointestinal Stromal Tumors

IFT172 GLI3 DISP1

5.17e-0450923C0238198
Diseaseleukemia

FOXM1 NCOA3 PPP1R13L

6.84e-0455923C0023418
DiseaseGlobal developmental delay

APC2 NBEA TAF1 CNOT1

8.11e-04133924C0557874
Diseaseglucose homeostasis measurement, glucose effectiveness measurement

MYO5C MYH14

9.83e-0415922EFO_0006833, EFO_0006896
DiseaseNon-Small Cell Lung Carcinoma

FOXM1 NCOA3 AKT1 AKT2

1.46e-03156924C0007131
Diseaseprostate adenocarcinoma (is_implicated_in)

AKT1 AKT2

1.76e-0320922DOID:2526 (is_implicated_in)
DiseaseColorectal Neoplasms

FLNC APC2 PAX8 WIF1 AKT1

1.78e-03277925C0009404
Diseaselung disease (is_implicated_in)

HLA-DPB1 MEFV

2.13e-0322922DOID:850 (is_implicated_in)
DiseaseLEOPARD Syndrome

PPP1R13L A2ML1

2.13e-0322922C0175704
Diseasemonocyte measurement

RPS18 FAM117B METTL17

2.17e-0382923EFO_0803547
Diseasemalignant astrocytoma (is_marker_for)

AKT1 AKT2

2.33e-0323922DOID:3069 (is_marker_for)
Diseasecortical thickness

KIF6 PDE8A SYT2 IRAG1 SEMA3A MALRD1 GLI3 GOLGA7 QSER1 SSH2

2.46e-0311139210EFO_0004840
DiseaseKallmann Syndrome

SEMA3A NSMF

2.98e-0326922C0162809

Protein segments in the cluster

PeptideGeneStartEntry
QLMKTERPRPNTFII

AKT1

61

P31749
QLMKTERPRPNTFVI

AKT2

61

P31751
KVARQDPRVAPMSNL

ARID3B

126

Q8IVW6
FVFMQKRGTPINRIP

ARID3B

226

Q8IVW6
SQQPKLQMRVPAVRL

EP400

3136

Q96L91
MKPIQRFPQFILLLQ

ARHGEF10

561

O15013
LNKMPPSFRRIIENV

ACTR8

556

Q9H981
QTVLRYNILPPTNMK

A2ML1

1311

A8K2U0
MTLQRRVQPRVNVSP

HLA-DPB1

116

P04440
LSNFIIQMLVTNRPP

ADCY4

596

Q8NFM4
MDQKAIFQQPPVGVR

DHX30

711

Q7L2E3
RVKPAGMQNSLPRNF

DISP1

1341

Q96F81
SSKIQARMEQQPTRP

EAF1

116

Q96JC9
RFPMQRNLVVIPKSV

AKR1B1

251

P15121
MRPQQAPVSGKVFIQ

GOLGA7

1

Q7Z5G4
IIRTKVQQPFNLPMD

PAX8

131

Q06710
PKQQFSTLAVRMPNR

QSER1

1161

Q2KHR3
LKLPNPSTVRFRAMQ

PCDH18

56

Q9HCL0
KPGMPSIFNRRANIN

RADX

651

Q6NSI4
ERLKQVNGMFPRLNP

GLI3

781

P10071
TRPQVVSLPNMRVQK

LEFTY1

336

O75610
SPKRNQRVAMVPQKF

LIN9

76

Q5TKA1
MEKNNLFPPRRVESN

SLC24A1

276

O60721
QRPIIQLMRTSQPEA

KCNH7

1081

Q9NS40
PQRSQKISNPVYRMQ

MMRN1

246

Q13201
IRAMNVNPKISFPPV

SPATA18

396

Q8TC71
MYNVTRPIEKLQNPI

TMEM63C

436

Q9P1W3
PGLKDFQIQVQPVRM

IRAG1

426

Q9Y6F6
LPRDQIQRMNPPKFS

MYH14

91

Q7Z406
KQQGLPVVMPVFDRN

PDE8A

756

O60658
KRQGLPVVMPVFDRN

PDE8B

811

O95263
QNVNTPILPRYVMVK

NCEH1

236

Q6PIU2
MLRPFNLVIPFAVQK

FLNC

1781

Q14315
TQPPLKFVRAPMVVQ

MED15

341

Q96RN5
KFVRAPMVVQQPPVQ

MED15

346

Q96RN5
MVKQTIQIFARVKPP

KIF6

1

Q6ZMV9
MQPAPQNKRRLSLVS

NSMF

61

Q6X4W1
PQKEPVRQQIHRMFL

TUBGCP5

871

Q96RT8
TMINLPQRAKPVQGF

KIAA1549L

1216

Q6ZVL6
PRSQIQRARPVKMAT

MEFV

41

O15553
LSIKFLPPQRNMEVV

IFT172

1321

Q9UG01
SNILKRFAEMNPPRQ

MED14

1416

O60244
TMNNKGLVRKPQPIR

FANCD2OS

81

Q96PS1
IKSLFPQQPMRAARI

MALRD1

1356

Q5VYJ5
PQPRARAFLAEVKQM

HCRTR1

276

O43613
FKVATQERNPQRVQM

RGL4

366

Q8IZJ4
HKTQRSPVRIPFMQR

APC2

1921

O95996
LRPQRPKSQVMNVIG

DOCK1

1736

Q14185
RFLMSLVNQVPKIVP

EIF3F

306

O00303
RLQPMRATVPFQLKQ

FAM117B

31

Q6P1L5
TRPQVVSLPNMRVQK

LEFTY2

336

O00292
MGRPFQKNRVKPQFR

LARP4

366

Q71RC2
KQSVQIPVFVMIRPR

CUTC

71

Q9NTM9
QQKRPNPELRRNMTI

FOXM1

341

Q08050
VAPRVRFLQKMQKQP

DDX10

506

Q13206
LQRTPMSALVFPNKI

HORMAD1

6

Q86X24
MRQVKNPFGLEITNP

CGRRF1

61

Q99675
IMSRLFVPNIQQTPK

C4orf54

986

D6RIA3
DLARRRQTVAQMPPQ

CEP295

271

Q9C0D2
LSSLVNPPMRQKRAV

ERVFC1

371

P60507
RQRPIPLSMIFKLQN

PPP1R13L

366

Q8WUF5
EIRARNPAFQPQTLM

METTL17

176

Q9H7H0
FMNKNPPARRTLADI

BYSL

136

Q13895
FVKRLLQVTCQQMPP

CEBPZ

586

Q03701
RQPPMAFQGISERQK

P2RY10

226

O00398
SLATTQMNPPKRRQV

PRR23D1

26

E9PI22
PQETLRRASMQPIQI

NUMA1

1961

Q14980
MRNIFKRNQEPIVAP

SYT2

1

Q8N9I0
PQPENMQPRTRRTKF

RHOXF1

96

Q8NHV9
MDKFVIRTPRIQNSP

TCEANC2

1

Q96MN5
KAPVARPRMSAQEQL

PLEKHA4

581

Q9H4M7
GIRPKQPRMLQENTR

TAF1

1756

P21675
INPSVPIRNIRMKFA

NBEA

61

Q8NFP9
RANIMRPRTNTPKQL

NCOA3

1156

Q9Y6Q9
RPRTNTPKQLRMQLQ

NCOA3

1161

Q9Y6Q9
RGNLQRNKLPETFMP

SEC31B

1001

Q9NQW1
NPVFPMNNRPIVIKT

SEMA3A

411

Q14563
VNSRMKFANSVPPNV

IMPG2

961

Q9BZV3
SLATTQMNPPKRRQV

PRR23D2

26

P0DMB1
AIQAQVRASPKMPAL

SDCBP2

16

Q9H190
RVRKPVNVQMLFSNP

TGM3

606

Q08188
MPTRFHINQPALKQR

ATAD1

251

Q8NBU5
QRAVQAPRPQNKMSY

C12orf50

306

Q8NA57
APFLRNVELTKPMQI

CNOT1

2076

A5YKK6
QVMAQRQQVQRRPAP

TRIM24

476

O15164
DAKVPIIPMFTQNIR

TMEM68

226

Q96MH6
PLLRSPIQRKNAMFN

RHCE

226

P18577
MVVQFARSARPKQDP

RNPC3

496

Q96LT9
VFMVQSIINRPRKSP

MPDZ

1236

O75970
RTVTKPNPSFMRQLE

SSH2

426

Q76I76
PMNPRARKNCSQIAL

SPDYE3

491

A6NKU9
RGKRMRPNSNTPVNE

ZNF609

371

O15014
ALNRVLQQIRVPPKM

TMCC1

101

O94876
QNGIPRQPKDVFRDM

TMCC1

311

O94876
RKAQQRMPAIPVNIH

WIF1

71

Q9Y5W5
TPYQAPVRRQMKAKQ

NUP153

281

P49790
QDLPPVRRQQTQERM

RPAP1

341

Q9BWH6
RVITIMQNPRQYKIP

RPS18

66

P62269
RRVMQPQILEVNFNP

TTLL12

596

Q14166
METVQLRNPPRRQLK

STK4

1

Q13043
LIKCPNQIVRQMFQR

USP34

2361

Q70CQ2
MNQPNVVPRINSRIL

UGGT1

686

Q9NYU2
VKPMTRPQAVNARDA

MYO5C

386

Q9NQX4