Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

UMODL1 CCDC47 SPOCK3 ENPP1 LRP1 LRP2 LRP4 NID1 SMOC1 SMOC2 NOTCH1 NOTCH4 CRB1

1.73e-067497013GO:0005509
GeneOntologyMolecularFunctioncargo receptor activity

LRP10 ENPP1 LRP1 LRP2 ENDOU

1.21e-0585705GO:0038024
GeneOntologyMolecularFunctionpeptide lactyltransferase (CoA-dependent) activity

CREBBP EP300

1.21e-052702GO:0120300
GeneOntologyMolecularFunctionhistone H3K27 acetyltransferase activity

CREBBP EP300

1.21e-052702GO:0044017
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP10 LRP1 LRP2

2.24e-0516703GO:0005041
GeneOntologyMolecularFunctionhistone H3K18 acetyltransferase activity

CREBBP EP300

3.63e-053702GO:0043993
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP10 LRP1 LRP2

5.24e-0521703GO:0030228
GeneOntologyMolecularFunctionextracellular matrix constituent, lubricant activity

MUC17 MUC4

7.24e-054702GO:0030197
GeneOntologyMolecularFunctionscavenger receptor activity

ENPP1 LRP1 ENDOU

1.14e-0427703GO:0005044
GeneOntologyMolecularFunctionbHLH transcription factor binding

LMO2 CREBBP EP300

2.94e-0437703GO:0043425
GeneOntologyMolecularFunctiontransition metal ion binding

ZMYND11 RNF5 ENPP1 RNF19B RNF8 PRICKLE2 LOXL4 ENDOU ZNF318 KDM1B CREBBP EP300

8.07e-0411897012GO:0046914
GeneOntologyMolecularFunctionzinc ion binding

ZMYND11 RNF5 ENPP1 RNF19B RNF8 PRICKLE2 ZNF318 KDM1B CREBBP EP300

1.04e-038917010GO:0008270
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

CREBBP EP300

1.24e-0315702GO:0010484
GeneOntologyMolecularFunctionprotein antigen binding

KLRC1 EP300

1.41e-0316702GO:1990405
GeneOntologyMolecularFunctionextracellular matrix binding

NID1 SMOC1 SMOC2

2.15e-0373703GO:0050840
GeneOntologyMolecularFunctionapolipoprotein binding

LRP1 LRP4

2.21e-0320702GO:0034185
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

CREBBP EP300

2.44e-0321702GO:0042975
GeneOntologyMolecularFunctionG-protein beta/gamma-subunit complex binding

GNAT3 GNAT2

3.45e-0325702GO:0031683
GeneOntologyMolecularFunctionNotch binding

NOTCH1 NOTCH4

4.02e-0327702GO:0005112
GeneOntologyMolecularFunctiontranscription coactivator activity

LMO2 CREBBP EP300 FHL5 NOTCH1

4.21e-03303705GO:0003713
GeneOntologyMolecularFunctionpeptidase inhibitor activity

CRIM1 UMODL1 WFDC9 SPOCK3

4.22e-03187704GO:0030414
GeneOntologyMolecularFunctionextracellular matrix structural constituent

MUC17 NID1 MUC4 MUC5AC

4.30e-03188704GO:0005201
GeneOntologyBiologicalProcessregulation of cellular response to growth factor stimulus

VWC2 CRIM1 LRP1 LRP2 KCP TWSG1 SMOC2 CREBBP EP300 NOTCH1

1.08e-064126910GO:0090287
GeneOntologyBiologicalProcessregulation of cell-substrate adhesion

VWC2 ADAM15 LRP1 NID1 SMOC1 SMOC2 MUC4 NOTCH1

2.07e-06254698GO:0010810
GeneOntologyBiologicalProcessregulation of transmembrane receptor protein serine/threonine kinase signaling pathway

VWC2 CRIM1 LRP1 LRP2 KCP TWSG1 CREBBP EP300 NOTCH1

2.27e-06347699GO:0090092
GeneOntologyBiologicalProcessregulation of BMP signaling pathway

VWC2 CRIM1 LRP2 KCP TWSG1 NOTCH1

5.05e-06131696GO:0030510
GeneOntologyBiologicalProcessnegative regulation of BMP signaling pathway

VWC2 CRIM1 LRP2 TWSG1 NOTCH1

7.16e-0680695GO:0030514
GeneOntologyBiologicalProcessaorta development

ENPP1 LRP1 LRP2 NOTCH1 NOTCH4

7.16e-0680695GO:0035904
GeneOntologyBiologicalProcesscell-substrate adhesion

VWC2 ITGBL1 ADAM15 LRP1 NID1 SMOC1 SMOC2 MUC4 NOTCH1

8.77e-06410699GO:0031589
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

VWC2 CRIM1 LRP1 LRP2 KCP TWSG1 CREBBP EP300 NOTCH1

1.68e-05445699GO:0141091
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

VWC2 CRIM1 LRP1 LRP2 KCP TWSG1 CREBBP EP300 NOTCH1

3.15e-05482699GO:0007178
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

VWC2 CRIM1 ENPP1 INSRR LRP1 LRP2 KCP LRP4 PLAT TWSG1 SMOC2 CREBBP EP300 NOTCH1

3.16e-0511866914GO:0007167
GeneOntologyBiologicalProcessprotein destabilization

RNF5 CHFR CREBBP EP300

3.69e-0556694GO:0031648
GeneOntologyBiologicalProcesspositive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

KCP TWSG1 CREBBP EP300 NOTCH1

4.17e-05115695GO:0090100
GeneOntologyBiologicalProcessBMP signaling pathway

VWC2 CRIM1 LRP2 KCP TWSG1 NOTCH1

5.11e-05197696GO:0030509
GeneOntologyBiologicalProcessregulation of cell adhesion

VWC2 ADAM15 LRP1 NID1 TWSG1 SMOC1 SMOC2 MUC4 EP300 NOTCH1 APBB1IP NOTCH4

5.24e-059276912GO:0030155
GeneOntologyBiologicalProcessWnt signaling pathway

ENPP1 WNT9B PRICKLE2 LRP1 LRP4 NID1 PRDM15 NOTCH1 ALPK2

5.35e-05516699GO:0016055
GeneOntologyBiologicalProcessstimulatory C-type lectin receptor signaling pathway

CREBBP KLRC1 EP300

6.05e-0523693GO:0002223
GeneOntologyBiologicalProcessregulation of cell adhesion molecule production

CREBBP NOTCH1 NOTCH4

6.05e-0523693GO:0060353
GeneOntologyBiologicalProcesscellular response to lectin

CREBBP KLRC1 EP300

6.05e-0523693GO:1990858
GeneOntologyBiologicalProcessresponse to lectin

CREBBP KLRC1 EP300

6.05e-0523693GO:1990840
GeneOntologyBiologicalProcesspositive regulation of aorta morphogenesis

NOTCH1 NOTCH4

6.59e-054692GO:1903849
GeneOntologyBiologicalProcessN-terminal peptidyl-lysine acetylation

CREBBP EP300

6.59e-054692GO:0018076
GeneOntologyBiologicalProcesstranscytosis

LRP1 LRP2 TG

6.90e-0524693GO:0045056
GeneOntologyBiologicalProcessdetection of light stimulus involved in visual perception

GNAT2 GRM6 CRB1

7.82e-0525693GO:0050908
GeneOntologyBiologicalProcessdetection of light stimulus involved in sensory perception

GNAT2 GRM6 CRB1

7.82e-0525693GO:0050962
GeneOntologyBiologicalProcessresponse to BMP

VWC2 CRIM1 LRP2 KCP TWSG1 NOTCH1

8.30e-05215696GO:0071772
GeneOntologyBiologicalProcesscellular response to BMP stimulus

VWC2 CRIM1 LRP2 KCP TWSG1 NOTCH1

8.30e-05215696GO:0071773
GeneOntologyBiologicalProcessartery development

ENPP1 LRP1 LRP2 NOTCH1 NOTCH4

8.35e-05133695GO:0060840
GeneOntologyBiologicalProcesscell adhesion molecule production

CREBBP NOTCH1 NOTCH4

8.82e-0526693GO:0060352
GeneOntologyBiologicalProcessnegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

VWC2 CRIM1 LRP1 LRP2 TWSG1 NOTCH1

8.96e-05218696GO:0090101
GeneOntologyBiologicalProcessresponse to tumor cell

ADAM15 ULBP1 MUC4 NOTCH1

9.41e-0571694GO:0002347
GeneOntologyBiologicalProcesspositive regulation of lysosomal protein catabolic process

LRP1 LRP2

1.10e-045692GO:1905167
GeneOntologyBiologicalProcesschemoattraction of axon

LRP1 LRP2

1.10e-045692GO:0061642
GeneOntologyBiologicalProcesspeptidyl-lysine acetylation

DIP2A CREBBP EP300

1.11e-0428693GO:0018394
GeneOntologyBiologicalProcessnegative regulation of cell-substrate adhesion

ADAM15 LRP1 MUC4 NOTCH1

1.11e-0474694GO:0010812
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

VWC2 CRIM1 ENPP1 LRP1 LRP2 KCP TWSG1 SMOC2 CREBBP EP300 NOTCH1

1.12e-048506911GO:0071363
GeneOntologyBiologicalProcessanatomical structure homeostasis

ENPP1 TNFRSF11A GNAT2 MUC4 MUC5AC NOTCH1 CRB1

1.25e-04334697GO:0060249
GeneOntologyBiologicalProcesstissue homeostasis

ENPP1 TNFRSF11A GNAT2 MUC4 MUC5AC NOTCH1 CRB1

1.25e-04334697GO:0001894
GeneOntologyBiologicalProcessresponse to abiotic stimulus

ADAM15 INSRR RNF8 PRICKLE2 LRP2 PLAT TNFRSF11A GNAT2 GRM6 CREBBP EP300 NOTCH1 CRB1 TG

1.39e-0413616914GO:0009628
GeneOntologyBiologicalProcesscell morphogenesis

DIP2A MYO9A ENPP1 LRP1 LRP2 LRP4 GNAT2 EP300 PDLIM5 EDN2 NOTCH1 NOTCH4 CRB1

1.43e-0411946913GO:0000902
GeneOntologyBiologicalProcessnegative regulation of cellular response to growth factor stimulus

VWC2 CRIM1 LRP2 TWSG1 NOTCH1

1.47e-04150695GO:0090288
GeneOntologyBiologicalProcessresponse to growth factor

VWC2 CRIM1 ENPP1 LRP1 LRP2 KCP TWSG1 SMOC2 CREBBP EP300 NOTCH1

1.56e-048836911GO:0070848
GeneOntologyBiologicalProcesspositive regulation of response to external stimulus

LRP1 ULBP1 PLAT TNFRSF11A SMOC2 CREBBP KLRC1 EP300 EDN2 SEC14L1

1.63e-047386910GO:0032103
GeneOntologyBiologicalProcessregulation of aorta morphogenesis

NOTCH1 NOTCH4

1.64e-046692GO:1903847
GeneOntologyBiologicalProcesspositive regulation of cellular response to transforming growth factor beta stimulus

TWSG1 CREBBP EP300

2.17e-0435693GO:1903846
GeneOntologyBiologicalProcesspositive regulation of transforming growth factor beta receptor signaling pathway

TWSG1 CREBBP EP300

2.17e-0435693GO:0030511
GeneOntologyBiologicalProcesspositive regulation of protein catabolic process in the vacuole

LRP1 LRP2

2.29e-047692GO:1904352
GeneOntologyBiologicalProcesspositive regulation of transcription of Notch receptor target

NOTCH1 NOTCH4

2.29e-047692GO:0007221
GeneOntologyBiologicalProcessartery morphogenesis

LRP1 LRP2 NOTCH1 NOTCH4

2.57e-0492694GO:0048844
GeneOntologyBiologicalProcessextracellular matrix organization

ADAM15 LRP1 LOXL4 NID1 SMOC1 SMOC2 NOTCH1

2.63e-04377697GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

ADAM15 LRP1 LOXL4 NID1 SMOC1 SMOC2 NOTCH1

2.67e-04378697GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

ADAM15 LRP1 LOXL4 NID1 SMOC1 SMOC2 NOTCH1

2.71e-04379697GO:0045229
GeneOntologyBiologicalProcessneuron development

DIP2A MYO9A ENPP1 PRICKLE2 LRP1 LRP2 LRP4 GNAT2 CREBBP EP300 PDLIM5 EDN2 NOTCH1 CRB1

2.94e-0414636914GO:0048666
GeneOntologyBiologicalProcessamyloid-beta clearance by cellular catabolic process

LRP1 LRP4

3.05e-048692GO:0150094
GeneOntologyBiologicalProcessamyloid-beta clearance

LRP1 LRP2 LRP4

3.24e-0440693GO:0097242
GeneOntologyBiologicalProcessaorta morphogenesis

LRP1 NOTCH1 NOTCH4

3.49e-0441693GO:0035909
GeneOntologyBiologicalProcesspositive regulation of BMP signaling pathway

KCP TWSG1 NOTCH1

3.75e-0442693GO:0030513
GeneOntologyBiologicalProcesspositive regulation of artery morphogenesis

NOTCH1 NOTCH4

3.91e-049692GO:1905653
GeneOntologyBiologicalProcesscell surface receptor signaling pathway involved in heart development

NOTCH1 ALPK2

3.91e-049692GO:0061311
GeneOntologyBiologicalProcessnegative regulation of cell-matrix adhesion

ADAM15 LRP1 MUC4

4.02e-0443693GO:0001953
GeneOntologyBiologicalProcesspositive regulation of muscle cell differentiation

NID1 EP300 NOTCH1 NOTCH4

4.41e-04106694GO:0051149
GeneOntologyBiologicalProcessprotein acylation

DIP2A ZDHHC13 CREBBP EP300

4.73e-04108694GO:0043543
GeneOntologyBiologicalProcesscoronary artery morphogenesis

LRP2 NOTCH1

4.88e-0410692GO:0060982
GeneOntologyBiologicalProcessnegative regulation of cell-cell adhesion mediated by cadherin

NOTCH1 NOTCH4

4.88e-0410692GO:2000048
GeneOntologyBiologicalProcesspost-embryonic animal morphogenesis

ENPP1 CRB1

4.88e-0410692GO:0009886
GeneOntologyBiologicalProcessosteoblast differentiation

CRIM1 CCDC47 ENPP1 TWSG1 SMOC1 NOTCH1

5.18e-04302696GO:0001649
GeneOntologyBiologicalProcessossification

CRIM1 CCDC47 ENPP1 LRP4 TWSG1 TNFRSF11A SMOC1 NOTCH1

5.61e-04562698GO:0001503
GeneOntologyBiologicalProcessnegative regulation of T cell mediated cytotoxicity

MUC4 KLRC1

5.95e-0411692GO:0001915
GeneOntologyBiologicalProcessnegative regulation of ossification

ENPP1 LRP4 NOTCH1

6.27e-0450693GO:0030279
GeneOntologyBiologicalProcesssensory organ development

LRP10 ENPP1 WNT9B TWSG1 GNAT2 SMOC1 GRM6 NOTCH1 CRB1

7.04e-04730699GO:0007423
GeneOntologyBiologicalProcessregulation of lysosomal protein catabolic process

LRP1 LRP2

7.12e-0412692GO:1905165
GeneOntologyBiologicalProcessregulation of T cell mediated cytotoxicity

ULBP1 MUC4 KLRC1

7.45e-0453693GO:0001914
GeneOntologyBiologicalProcessvenous blood vessel morphogenesis

NOTCH1 NOTCH4

8.40e-0413692GO:0048845
GeneOntologyBiologicalProcesscollecting duct development

WNT9B NOTCH1

8.40e-0413692GO:0072044
GeneOntologyBiologicalProcessimmune response to tumor cell

ADAM15 ULBP1 MUC4

8.75e-0456693GO:0002418
GeneOntologyBiologicalProcessadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

ENPP1 RNF8 ULBP1 MUC4 KLRC1 EP300 NOTCH1

8.81e-04462697GO:0002460
GeneOntologyBiologicalProcessdetection of visible light

GNAT2 GRM6 CRB1

9.21e-0457693GO:0009584
GeneOntologyBiologicalProcesslimb development

ENPP1 LRP4 SMOC1 CREBBP NOTCH1

9.23e-04224695GO:0060173
GeneOntologyBiologicalProcessappendage development

ENPP1 LRP4 SMOC1 CREBBP NOTCH1

9.23e-04224695GO:0048736
GeneOntologyBiologicalProcessestablishment or maintenance of epithelial cell apical/basal polarity

MYO9A PRICKLE2 CRB1

9.69e-0458693GO:0045197
GeneOntologyBiologicalProcessregulation of protein catabolic process in the vacuole

LRP1 LRP2

9.78e-0414692GO:1904350
GeneOntologyBiologicalProcesscardiac cell development

EP300 PDLIM5 NOTCH1 ALPK2

1.00e-03132694GO:0055006
GeneOntologyBiologicalProcessneuron projection development

DIP2A MYO9A ENPP1 PRICKLE2 LRP1 LRP2 LRP4 CREBBP EP300 PDLIM5 EDN2 NOTCH1

1.05e-0312856912GO:0031175
GeneOntologyBiologicalProcesseye development

WNT9B TWSG1 GNAT2 SMOC1 GRM6 NOTCH1 CRB1

1.10e-03480697GO:0001654
GeneOntologyBiologicalProcessvisual system development

WNT9B TWSG1 GNAT2 SMOC1 GRM6 NOTCH1 CRB1

1.14e-03483697GO:0150063
GeneOntologyBiologicalProcesssex differentiation

UMODL1 ADAM15 WNT9B LRP2 EDN2 NOTCH1

1.15e-03352696GO:0007548
GeneOntologyBiologicalProcessestablishment or maintenance of bipolar cell polarity

MYO9A PRICKLE2 CRB1

1.23e-0363693GO:0061245
GeneOntologyBiologicalProcessestablishment or maintenance of apical/basal cell polarity

MYO9A PRICKLE2 CRB1

1.23e-0363693GO:0035088
GeneOntologyBiologicalProcesssensory system development

WNT9B TWSG1 GNAT2 SMOC1 GRM6 NOTCH1 CRB1

1.25e-03491697GO:0048880
GeneOntologyBiologicalProcessnegative regulation of cell adhesion molecule production

NOTCH1 NOTCH4

1.28e-0316692GO:0060354
GeneOntologyBiologicalProcessN-terminal protein amino acid acetylation

CREBBP EP300

1.28e-0316692GO:0006474
GeneOntologyBiologicalProcessregulation of cellular response to heat

CREBBP EP300

1.28e-0316692GO:1900034
GeneOntologyBiologicalProcessneuron projection morphogenesis

DIP2A MYO9A LRP1 LRP2 LRP4 EP300 PDLIM5 EDN2 NOTCH1

1.36e-03802699GO:0048812
GeneOntologyBiologicalProcessresponse to radiation

RNF8 LRP2 GNAT2 GRM6 CREBBP EP300 CRB1

1.44e-03503697GO:0009314
GeneOntologyBiologicalProcessregulation of artery morphogenesis

NOTCH1 NOTCH4

1.45e-0317692GO:1905651
GeneOntologyBiologicalProcesskidney development

ENPP1 WNT9B LRP2 LRP4 NID1 NOTCH1

1.52e-03372696GO:0001822
GeneOntologyBiologicalProcessprotein acetylation

DIP2A CREBBP EP300

1.54e-0368693GO:0006473
GeneOntologyBiologicalProcessregeneration

ADAM15 ENPP1 LRP1 GNAT2 NOTCH1

1.56e-03252695GO:0031099
GeneOntologyBiologicalProcesspositive regulation of cell-substrate adhesion

VWC2 NID1 SMOC1 SMOC2

1.57e-03149694GO:0010811
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

DIP2A MYO9A LRP1 LRP2 LRP4 EP300 PDLIM5 EDN2 NOTCH1

1.57e-03819699GO:0120039
GeneOntologyBiologicalProcessnegative regulation of cell adhesion

ADAM15 LRP1 TWSG1 MUC4 NOTCH1 NOTCH4

1.59e-03375696GO:0007162
GeneOntologyCellularComponentcell surface

DIP2A ITGBL1 UMODL1 MUC17 ADAM15 ENPP1 LRP1 LRP2 LRP4 ULBP1 PLAT TNFRSF11A KLRC1 NOTCH1 NOTCH4

3.84e-0611117115GO:0009986
GeneOntologyCellularComponentextracellular matrix

VWC2 MUC17 SPOCK3 LOXL4 NID1 PLAT MUC5B SMOC1 SMOC2 MUC4 MUC5AC

1.24e-056567111GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

VWC2 MUC17 SPOCK3 LOXL4 NID1 PLAT MUC5B SMOC1 SMOC2 MUC4 MUC5AC

1.27e-056587111GO:0030312
GeneOntologyCellularComponentreceptor complex

VWC2 ITGBL1 INSRR LRP1 LRP2 LOXL4 KLRC1 NOTCH1 APBB1IP

1.49e-04581719GO:0043235
GeneOntologyCellularComponentcollagen-containing extracellular matrix

VWC2 MUC17 LOXL4 NID1 PLAT SMOC1 SMOC2 MUC4

4.24e-04530718GO:0062023
GeneOntologyCellularComponentaxonal growth cone

MYO9A LRP1 LRP2

4.81e-0445713GO:0044295
GeneOntologyCellularComponentGolgi lumen

MUC17 MUC5B MUC4 MUC5AC

5.19e-04109714GO:0005796
GeneOntologyCellularComponentbasement membrane

VWC2 NID1 SMOC1 SMOC2

7.93e-04122714GO:0005604
GeneOntologyCellularComponentapical part of cell

MUC17 LRP1 LRP2 GNAT3 PLAT MUC4 NOTCH1 CRB1

8.75e-04592718GO:0045177
GeneOntologyCellularComponentplasma membrane protein complex

VWC2 ITGBL1 WNT9B INSRR LRP1 GNAT3 GNAT2 APBB1IP CRB1

1.32e-03785719GO:0098797
GeneOntologyCellularComponentinterstitial matrix

VWC2 SMOC2

1.50e-0317712GO:0005614
GeneOntologyCellularComponentexternal side of plasma membrane

UMODL1 MUC17 LRP1 LRP2 ULBP1 TNFRSF11A KLRC1

1.88e-03519717GO:0009897
GeneOntologyCellularComponentpostsynapse

VWC2 DIP2A MYO9A PRICKLE2 LRP1 LRP4 PLAT GRM6 PDLIM5 NOTCH1

2.23e-0310187110GO:0098794
GeneOntologyCellularComponentphotoreceptor inner segment

GNAT3 GNAT2 CRB1

2.38e-0378713GO:0001917
GeneOntologyCellularComponentclathrin-coated pit

LRP10 LRP1 LRP2

2.56e-0380713GO:0005905
GeneOntologyCellularComponentside of membrane

UMODL1 MUC17 LRP1 LRP2 GNAT3 ULBP1 TNFRSF11A GNAT2 KLRC1

2.75e-03875719GO:0098552
GeneOntologyCellularComponentouter kinetochore

BUB1B CREBBP

2.99e-0324712GO:0000940
HumanPhenoAbnormal pulmonary valve physiology

ENPP1 BUB1B LRP4 MUC5B CREBBP EP300 NOTCH1

2.41e-06163217HP:0031654
HumanPhenoAbnormal pulmonary valve morphology

ENPP1 BUB1B LRP4 MUC5B CREBBP EP300 NOTCH1

8.82e-06198217HP:0001641
HumanPhenoPulmonic stenosis

ENPP1 BUB1B LRP4 CREBBP EP300 NOTCH1

1.38e-05138216HP:0001642
HumanPhenoPlantar crease between first and second toes

CREBBP EP300

1.62e-052212HP:0008107
HumanPhenoAortic isthmus hypoplasia

CREBBP EP300

1.62e-052212HP:0034227
HumanPhenoHigh axial triradius

CREBBP EP300

1.62e-052212HP:0001042
HumanPhenoLaryngeal cartilage malformation

CREBBP EP300

4.84e-053212HP:0008752
HumanPhenoPhobia

CREBBP EP300

4.84e-053212HP:5200232
HumanPhenoAgoraphobia

CREBBP EP300

4.84e-053212HP:0000756
HumanPhenoHumoral immunodeficiency

CREBBP EP300

4.84e-053212HP:0005363
HumanPhenoProminent nasal septum

CREBBP EP300

4.84e-053212HP:0005322
HumanPhenoRadial deviation of thumb terminal phalanx

CREBBP EP300

4.84e-053212HP:0005895
HumanPhenoTrichiasis

CREBBP EP300

9.67e-054212HP:0001128
HumanPhenoVisceral hemangioma

CREBBP EP300

9.67e-054212HP:0410266
HumanPhenoTalon cusp

CREBBP EP300

9.67e-054212HP:0011087
HumanPhenoWidened distal phalanges

CREBBP EP300

9.67e-054212HP:0006200
HumanPhenoVascular ring

CREBBP EP300

9.67e-054212HP:0010775
HumanPhenoHepatic hemangioma

CREBBP EP300

9.67e-054212HP:0031207
HumanPhenoSimple ear

CCDC47 CREBBP EP300

1.16e-0424213HP:0020206
HumanPhenoHypoplasia of teeth

ENPP1 LRP4 SMOC2 CREBBP EP300

1.27e-04126215HP:0000685
HumanPhenoPapillary cystadenoma of the epididymis

CREBBP EP300

1.61e-045212HP:0009715
HumanPhenoSupernumerary cusp

CREBBP EP300

1.61e-045212HP:0033777
HumanPhenoEpididymal neoplasm

CREBBP EP300

1.61e-045212HP:0030421
HumanPhenoPolyhydramnios

MYO9A CCDC47 ENPP1 WNT9B BUB1B CREBBP EP300

1.67e-04312217HP:0001561
HumanPhenoLower extremity joint dislocation

MYO9A CCDC47 LRP1 LRP4 SMOC1 CREBBP EP300

1.88e-04318217HP:0030311
HumanPhenoAplasia of the toes

LRP4 SMOC1 EP300 NOTCH1

2.04e-0474214HP:0011306
HumanPhenoAbsent toe

LRP4 SMOC1 EP300 NOTCH1

2.04e-0474214HP:0010760
HumanPhenoLarge foramen magnum

CREBBP EP300

2.40e-046212HP:0002700
HumanPhenoObstructive sleep apnea

MYO9A CCDC47 CREBBP EP300

2.62e-0479214HP:0002870
HumanPhenoElbow dislocation

LRP4 SMOC1 CREBBP EP300

3.33e-0484214HP:0003042
HumanPhenoDeviated nasal septum

CREBBP EP300

3.36e-047212HP:0004411
HumanPhenoAbnormal sternum morphology

MYO9A CCDC47 BUB1B LRP2 LRP4 TNFRSF11A CREBBP EP300

3.62e-04474218HP:0000766
HumanPhenoAbnormal hip joint morphology

MYO9A CCDC47 ENPP1 LRP1 LRP4 SMOC1 CREBBP EP300

4.54e-04490218HP:0001384
HumanPhenoAbnormal synovial membrane morphology

MYO9A CCDC47 ENPP1 LRP1 LRP4 SMOC1 CREBBP EP300

5.44e-04503218HP:0005262
HumanPhenoUpper extremity joint dislocation

LRP4 SMOC1 CREBBP EP300

5.54e-0496214HP:0030310
HumanPhenoPilomatrixoma

CREBBP EP300

5.73e-049212HP:0030434
HumanPhenoCervical cord compression

CREBBP EP300

5.73e-049212HP:0002341
HumanPhenoAbnormal hip bone morphology

MYO9A CCDC47 ENPP1 LRP1 LRP4 SMOC1 CREBBP EP300 TG

6.19e-04653219HP:0003272
HumanPhenoJoint dislocation

MYO9A CCDC47 LRP1 LRP4 SMOC1 CREBBP EP300

6.61e-04390217HP:0001373
HumanPhenoFrontal hirsutism

CREBBP EP300

7.14e-0410212HP:0011335
HumanPhenoCutaneous syndactyly

LRP4 SMOC1 CREBBP EP300

7.24e-04103214HP:0012725
HumanPhenoEnamel hypoplasia

LRP4 SMOC2 CREBBP EP300

7.51e-04104214HP:0006297
HumanPhenoAbnormality of vision

CLCN4 MYO9A CCDC47 ENPP1 BUB1B LRP1 LRP2 LRP4 TNFRSF11A GNAT2 GRM6 CREBBP CRB1

7.98e-0413732113HP:0000504
HumanPhenoAbnormal heart valve physiology

ENPP1 BUB1B LRP4 MUC5B CREBBP EP300 NOTCH1

8.06e-04403217HP:0031653
HumanPhenoHypermetropia

CCDC47 GNAT2 GRM6 CREBBP EP300 CRB1

8.17e-04288216HP:0000540
HumanPhenoFoot oligodactyly

LRP4 SMOC1

8.71e-0411212HP:0001849
HumanPhenoAbnormal subclavian artery morphology

CREBBP EP300

8.71e-0411212HP:0031251
HumanPhenoHypoplastic left heart

CREBBP EP300 NOTCH1

9.85e-0449213HP:0004383
HumanPhenoAbnormal dental morphology

CCDC47 TNFRSF11A SMOC1 SMOC2 CREBBP EP300

9.96e-04299216HP:0006482
HumanPhenoAortic valve stenosis

BUB1B CREBBP EP300 NOTCH1

1.03e-03113214HP:0001650
HumanPhenoCutaneous syndactyly of toes

SMOC1 CREBBP EP300

1.05e-0350213HP:0010621
HumanPhenoAbnormal morphology of bones of the lower limbs

CCDC47 ENPP1 TNFRSF11A SMOC1 CREBBP EP300 TG

1.06e-03422217HP:0040066
HumanPhenoAbnormal midface morphology

CLCN4 CCDC47 BUB1B LRP1 LRP2 LRP4 SMOC1 CREBBP EP300

1.08e-03704219HP:0000309
HumanPhenoAbnormal femur morphology

CCDC47 ENPP1 TNFRSF11A CREBBP EP300 TG

1.09e-03304216HP:0002823
HumanPhenoAbnormal femoral neck/head morphology

CCDC47 ENPP1 CREBBP EP300 TG

1.10e-03201215HP:0003366
HumanPhenoCongenital malformation of the left heart

CREBBP EP300 NOTCH1

1.11e-0351213HP:0045017
HumanPhenoCyanosis

MYO9A ENPP1 LRP4 MUC5B

1.17e-03117214HP:0000961
HumanPhenoFacial grimacing

CREBBP EP300

1.23e-0313212HP:0000273
HumanPhenoKeloids

CREBBP EP300

1.23e-0313212HP:0010562
HumanPhenoShort sternum

BUB1B LRP2

1.23e-0313212HP:0000879
HumanPhenoHyperkeratotic papule

ENPP1 LRP1

1.23e-0313212HP:0045059
HumanPhenoHypoplastic heart

CREBBP EP300 NOTCH1

1.31e-0354213HP:0001961
HumanPhenoAbnormality of globe location or size

ZMYND11 CCDC47 WNT9B BUB1B LRP2 LRP4 TNFRSF11A SMOC1 CREBBP EP300 NOTCH1 CRB1

1.34e-0312462112HP:0000489
HumanPhenoAbnormal pelvic girdle bone morphology

MYO9A CCDC47 ENPP1 LRP1 LRP4 SMOC1 CREBBP EP300 TG

1.41e-03730219HP:0002644
HumanPhenoAbnormal calvaria morphology

ZMYND11 CCDC47 ENPP1 BUB1B LRP2 LRP4 TNFRSF11A SMOC1 CREBBP EP300 NOTCH1 TG

1.43e-0312542112HP:0002683
HumanPhenoDuplication of phalanx of hallux

CREBBP EP300

1.43e-0314212HP:0010066
HumanPhenoHypoplastic aortic arch

CREBBP EP300

1.43e-0314212HP:0012304
HumanPhenoParietal foramina

CREBBP EP300

1.43e-0314212HP:0002697
HumanPhenoAbnormality of the thigh

CCDC47 ENPP1 TNFRSF11A CREBBP EP300 TG

1.47e-03322216HP:0001439
HumanPhenoDuplication of phalanx of toe

CREBBP EP300

1.65e-0315212HP:0010181
HumanPhenoSocial and occupational deterioration

CREBBP EP300

1.65e-0315212HP:0007086
HumanPhenoAbnormal dental enamel morphology

LRP4 TNFRSF11A SMOC2 CREBBP EP300

1.69e-03221215HP:0000682
HumanPhenoHypoplastic facial bones

BUB1B LRP2 LRP4 SMOC1 CREBBP EP300

1.69e-03331216HP:0002692
HumanPhenoAplasia/Hypoplasia of facial bones

BUB1B LRP2 LRP4 SMOC1 CREBBP EP300

1.72e-03332216HP:0034261
MousePhenoabnormal blood vessel morphology

ZMYND11 CRIM1 LMO2 MYO9A ADAM15 ENPP1 LRP2 NID1 WSB2 PLAT GNAT2 SMOC1 ZDHHC13 CREBBP EP300 EDN2 NOTCH1 NOTCH4 CRB1

5.33e-0614725919MP:0001614
MousePhenoabnormal postnatal growth

DIP2A MYO9A ENPP1 BUB1B RNF8 LRP4 MUC5B TWSG1 SMOC1 ZDHHC13 CREBBP EDN2 NOTCH1 TG

1.81e-059075914MP:0001731
MousePhenoabnormal craniofacial morphology

DIP2A ZMYND11 CRIM1 ENPP1 WNT9B LRP1 LRP2 LRP4 WSB2 TWSG1 TNFRSF11A SMOC1 SMOC2 CREBBP MFSD12 EP300 NOTCH1

3.34e-0513725917MP:0000428
MousePhenocraniofacial phenotype

DIP2A ZMYND11 CRIM1 ENPP1 WNT9B LRP1 LRP2 LRP4 WSB2 TWSG1 TNFRSF11A SMOC1 SMOC2 CREBBP MFSD12 EP300 NOTCH1

3.34e-0513725917MP:0005382
MousePhenoperimembraneous ventricular septal defect

ZMYND11 CRIM1 LRP2 CREBBP EP300

4.19e-0592595MP:0010418
MousePhenoabnormal interventricular septum membranous part morphology

ZMYND11 CRIM1 LRP2 CREBBP EP300

4.41e-0593595MP:0008823
MousePhenoabnormal Mullerian duct morphology

ZMYND11 CRIM1 MYO9A WNT9B

4.46e-0547594MP:0003826
MousePhenopostnatal growth retardation

DIP2A MYO9A ENPP1 BUB1B RNF8 MUC5B TWSG1 SMOC1 ZDHHC13 CREBBP EDN2 NOTCH1 TG

6.09e-058815913MP:0001732
MousePhenoabnormal axial skeleton morphology

DIP2A ZMYND11 CRIM1 MYO9A ENPP1 BUB1B LRP2 LRP4 WSB2 TWSG1 TNFRSF11A SMOC1 SMOC2 ZDHHC13 CREBBP MFSD12 NOTCH1

7.24e-0514585917MP:0002114
MousePhenoabnormal facial morphology

DIP2A ZMYND11 ENPP1 WNT9B LRP2 LRP4 WSB2 TWSG1 TNFRSF11A SMOC1 SMOC2 CREBBP EP300

8.48e-059105913MP:0003743
MousePhenoabnormal mouth morphology

DIP2A ZMYND11 WNT9B LRP2 LRP4 WSB2 TWSG1 TNFRSF11A SMOC1 SMOC2 CREBBP

9.64e-056705911MP:0000452
MousePhenoabnormal heart ventricle morphology

ZMYND11 CRIM1 RNF19B CHFR LRP1 LRP2 PLAT PRDM15 CREBBP EP300 PDLIM5 NOTCH1

9.69e-057935912MP:0005294
MousePhenoabnormal cranium morphology

DIP2A CRIM1 ENPP1 LRP2 LRP4 WSB2 TWSG1 TNFRSF11A SMOC1 SMOC2 CREBBP MFSD12

1.23e-048135912MP:0000438
MousePhenoabnormal craniofacial bone morphology

DIP2A CRIM1 ENPP1 LRP2 LRP4 WSB2 TWSG1 TNFRSF11A SMOC1 SMOC2 CREBBP MFSD12

1.44e-048275912MP:0002116
MousePhenoabnormal head morphology

DIP2A ZMYND11 ENPP1 WNT9B LRP2 LRP4 WSB2 TWSG1 TNFRSF11A SMOC1 SMOC2 PRDM15 CREBBP EP300

1.80e-0411205914MP:0000432
MousePhenodecreased thymocyte number

RNF8 TWSG1 CREBBP EP300 NOTCH1

1.93e-04127595MP:0000715
MousePhenoabnormal mesonephros morphology

ZMYND11 CRIM1 MYO9A WNT9B

2.38e-0472594MP:0008487
MousePhenoincreased heart left ventricle size

RNF19B LRP2 PLAT PRDM15 PDLIM5

2.48e-04134595MP:0010579
MousePhenoabnormal respiratory mechanics

ENPP1 CHFR MUC5B EDN2 APBB1IP

2.57e-04135595MP:0002314
MousePhenoabnormal eye vasculature morphology

ADAM15 WSB2 PLAT GNAT2 SMOC1 NOTCH1 NOTCH4 CRB1

3.32e-04415598MP:0031346
MousePhenoabnormal jaw morphology

DIP2A LRP2 LRP4 WSB2 TWSG1 TNFRSF11A SMOC1 CREBBP MFSD12

3.50e-04530599MP:0000454
MousePhenopremature death

ENPP1 WNT9B BUB1B CHFR RNF8 MUC5B TWSG1 TNFRSF11A ZDHHC13 CREBBP MFSD12 EDN2 NOTCH1

3.55e-0410515913MP:0002083
MousePhenofused metatarsal bones

LRP4 SMOC1

3.63e-047592MP:0004642
DomainEGF

ITGBL1 UMODL1 MUC17 ADAM15 LRP1 LRP2 LRP4 NID1 PLAT MUC4 NOTCH1 NOTCH4 CRB1

4.33e-122357113SM00181
DomainEGF-like_dom

ITGBL1 UMODL1 MUC17 ADAM15 LRP1 LRP2 LRP4 NID1 PLAT MUC4 NOTCH1 NOTCH4 CRB1

8.99e-122497113IPR000742
DomainEGF_1

ITGBL1 UMODL1 MUC17 ADAM15 LRP1 LRP2 LRP4 NID1 PLAT MUC4 NOTCH1 NOTCH4 CRB1

1.21e-112557113PS00022
DomainEGF_2

ITGBL1 UMODL1 MUC17 ADAM15 LRP1 LRP2 LRP4 NID1 PLAT MUC4 NOTCH1 NOTCH4 CRB1

1.97e-112657113PS01186
DomainEGF_3

UMODL1 MUC17 ADAM15 LRP1 LRP2 LRP4 NID1 PLAT MUC4 NOTCH1 NOTCH4 CRB1

7.91e-112357112PS50026
DomainEGF-like_CS

UMODL1 MUC17 ADAM15 LRP1 LRP2 LRP4 NID1 PLAT MUC4 NOTCH1 NOTCH4 CRB1

2.66e-102617112IPR013032
DomainGrowth_fac_rcpt_

CRIM1 UMODL1 INSRR LRP1 LRP2 LRP4 NID1 NOTCH1 NOTCH4 CRB1

3.69e-101567110IPR009030
DomainEGF

LRP1 LRP2 LRP4 NID1 PLAT MUC4 NOTCH1 NOTCH4 CRB1

1.14e-09126719PF00008
DomainEGF_Ca-bd_CS

UMODL1 LRP1 LRP2 LRP4 NID1 NOTCH1 NOTCH4 CRB1

3.21e-0997718IPR018097
DomainEGF_CA

UMODL1 LRP1 LRP2 LRP4 NID1 NOTCH1 NOTCH4 CRB1

3.78e-0999718PS01187
DomainASX_HYDROXYL

UMODL1 LRP1 LRP2 LRP4 NID1 NOTCH1 NOTCH4 CRB1

4.10e-09100718PS00010
DomainTY

SPOCK3 NID1 SMOC1 SMOC2 TG

4.11e-0917715SM00211
Domain-

SPOCK3 NID1 SMOC1 SMOC2 TG

4.11e-09177154.10.800.10
DomainTHYROGLOBULIN_1_2

SPOCK3 NID1 SMOC1 SMOC2 TG

4.11e-0917715PS51162
DomainThyroglobulin_1

SPOCK3 NID1 SMOC1 SMOC2 TG

4.11e-0917715IPR000716
DomainThyroglobulin_1

SPOCK3 NID1 SMOC1 SMOC2 TG

4.11e-0917715PF00086
DomainTHYROGLOBULIN_1_1

SPOCK3 NID1 SMOC1 SMOC2 TG

4.11e-0917715PS00484
DomainEGF-type_Asp/Asn_hydroxyl_site

UMODL1 LRP1 LRP2 LRP4 NID1 NOTCH1 NOTCH4 CRB1

6.52e-09106718IPR000152
DomainEGF_CA

UMODL1 LRP1 LRP2 LRP4 NID1 NOTCH1 NOTCH4 CRB1

1.98e-08122718SM00179
DomainEGF-like_Ca-bd_dom

UMODL1 LRP1 LRP2 LRP4 NID1 NOTCH1 NOTCH4 CRB1

2.25e-08124718IPR001881
DomainEGF_CA

UMODL1 LRP1 LRP2 LRP4 NID1 NOTCH1 NOTCH4

3.59e-0886717PF07645
DomainVWC

VWC2 CRIM1 KCP MUC5B MUC5AC

6.32e-0828715PF00093
DomainTIL_dom

LRP2 KCP MUC5B MUC5AC

1.86e-0714714IPR002919
DomainLdl_recept_b

LRP1 LRP2 LRP4 NID1

1.86e-0714714PF00058
DomainLDLRB

LRP1 LRP2 LRP4 NID1

1.86e-0714714PS51120
DomainVWFC_1

VWC2 CRIM1 KCP MUC5B MUC5AC

2.37e-0736715PS01208
DomainLY

LRP1 LRP2 LRP4 NID1

2.54e-0715714SM00135
DomainLDLR_classB_rpt

LRP1 LRP2 LRP4 NID1

2.54e-0715714IPR000033
DomainVWC

VWC2 CRIM1 KCP MUC5B MUC5AC

3.13e-0738715SM00214
DomainVWFC_2

VWC2 CRIM1 KCP MUC5B MUC5AC

3.13e-0738715PS50184
DomainVWD

KCP MUC5B MUC4 MUC5AC

3.37e-0716714SM00216
DomainVWF_type-D

KCP MUC5B MUC4 MUC5AC

3.37e-0716714IPR001846
DomainVWFD

KCP MUC5B MUC4 MUC5AC

3.37e-0716714PS51233
DomainVWD

KCP MUC5B MUC4 MUC5AC

3.37e-0716714PF00094
DomainVWF_dom

VWC2 CRIM1 KCP MUC5B MUC5AC

5.25e-0742715IPR001007
DomainVWC_out

CRIM1 KCP MUC5B MUC5AC

7.12e-0719714SM00215
DomaincEGF

LRP1 LRP2 LRP4 NID1

2.69e-0626714IPR026823
DomaincEGF

LRP1 LRP2 LRP4 NID1

2.69e-0626714PF12662
DomainSPARC_Ca_bdg

SPOCK3 SMOC1 SMOC2

2.91e-068713PF10591
DomainSPARC/Testican_Ca-bd-dom

SPOCK3 SMOC1 SMOC2

2.91e-068713IPR019577
DomainNuc_rcpt_coact_CREBbp

CREBBP EP300

1.42e-052712IPR014744
DomainHAT_KAT11

CREBBP EP300

1.42e-052712PF08214
DomainKIX

CREBBP EP300

1.42e-052712PS50952
DomainZnF_TAZ

CREBBP EP300

1.42e-052712SM00551
DomainCBP_P300_HAT

CREBBP EP300

1.42e-052712IPR031162
DomainDUF902

CREBBP EP300

1.42e-052712PF06001
Domain-

CREBBP EP300

1.42e-0527121.20.1020.10
DomainRING_CBP-p300

CREBBP EP300

1.42e-052712IPR010303
Domain-

CREBBP EP300

1.42e-0527121.10.1630.10
DomainCreb_binding

CREBBP EP300

1.42e-052712PF09030
Domain-

CREBBP EP300

1.42e-0527121.10.246.20
Domainzf-TAZ

CREBBP EP300

1.42e-052712PF02135
DomainZF_TAZ

CREBBP EP300

1.42e-052712PS50134
DomainHistone_AcTrfase_Rtt109/CBP

CREBBP EP300

1.42e-052712IPR013178
DomainKAT11

CREBBP EP300

1.42e-052712SM01250
DomainZnf_TAZ

CREBBP EP300

1.42e-052712IPR000197
DomainKIX_dom

CREBBP EP300

1.42e-052712IPR003101
DomainKIX

CREBBP EP300

1.42e-052712PF02172
DomainCBP_P300_HAT

CREBBP EP300

1.42e-052712PS51727
Domain-

LRP1 LRP2 LRP4 NID1

1.43e-05397142.120.10.30
DomainUnchr_dom_Cys-rich

KCP MUC5B MUC5AC

1.47e-0513713IPR014853
DomainC8

KCP MUC5B MUC5AC

1.47e-0513713SM00832
DomainLDLR_class-A_CS

LRP10 LRP1 LRP2 LRP4

1.58e-0540714IPR023415
DomainLdl_recept_a

LRP10 LRP1 LRP2 LRP4

2.54e-0545714PF00057
Domain-

LRP10 LRP1 LRP2 LRP4

2.77e-05467144.10.400.10
Domain6-blade_b-propeller_TolB-like

LRP1 LRP2 LRP4 NID1

2.77e-0546714IPR011042
DomainLDLRA_1

LRP10 LRP1 LRP2 LRP4

3.29e-0548714PS01209
DomainLDLRA_2

LRP10 LRP1 LRP2 LRP4

3.57e-0549714PS50068
DomainLDrepeatLR_classA_rpt

LRP10 LRP1 LRP2 LRP4

3.57e-0549714IPR002172
DomainLDLa

LRP10 LRP1 LRP2 LRP4

3.57e-0549714SM00192
DomainEGF_extracell

ITGBL1 ADAM15 LRP2 NOTCH1

7.96e-0560714IPR013111
DomainEGF_2

ITGBL1 ADAM15 LRP2 NOTCH1

7.96e-0560714PF07974
DomainNotch

NOTCH1 NOTCH4

8.51e-054712IPR008297
DomainNODP

NOTCH1 NOTCH4

8.51e-054712PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH4

8.51e-054712IPR011656
DomainNotch_NOD_dom

NOTCH1 NOTCH4

8.51e-054712IPR010660
DomainNOD

NOTCH1 NOTCH4

8.51e-054712PF06816
DomainNOD

NOTCH1 NOTCH4

8.51e-054712SM01338
DomainNODP

NOTCH1 NOTCH4

8.51e-054712SM01339
DomainLIM

LMO2 PRICKLE2 FHL5 PDLIM5

1.38e-0469714PF00412
DomainNIDO_dom

NID1 MUC4

1.41e-045712IPR003886
DomainNIDO

NID1 MUC4

1.41e-045712SM00539
DomainNIDO

NID1 MUC4

1.41e-045712PF06119
DomainSomatomedin_B_chordata

ENPP1 ENDOU

1.41e-045712IPR020436
DomainLNR

NOTCH1 NOTCH4

1.41e-045712PS50258
DomainNIDO

NID1 MUC4

1.41e-045712PS51220
Domain-

LMO2 PRICKLE2 FHL5 PDLIM5

1.45e-04707142.10.110.10
DomainZnf_LIM

LMO2 PRICKLE2 FHL5 PDLIM5

1.54e-0471714IPR001781
DomainLIM_DOMAIN_1

LMO2 PRICKLE2 FHL5 PDLIM5

1.54e-0471714PS00478
DomainLIM_DOMAIN_2

LMO2 PRICKLE2 FHL5 PDLIM5

1.54e-0471714PS50023
DomainLIM

LMO2 PRICKLE2 FHL5 PDLIM5

1.54e-0471714SM00132
DomainhEGF

NOTCH1 NOTCH4 CRB1

1.61e-0428713PF12661
DomainNuc_rcpt_coact

CREBBP EP300

2.12e-046712IPR009110
DomainWxxW_domain

MUC5B MUC5AC

2.12e-046712IPR025155
DomainMucin2_WxxW

MUC5B MUC5AC

2.12e-046712PF13330
DomainNotch_dom

NOTCH1 NOTCH4

2.96e-047712IPR000800
DomainNotch

NOTCH1 NOTCH4

2.96e-047712PF00066
DomainHirudin/antistatin

CRIM1 MUC5AC

2.96e-047712IPR011061
DomainNL

NOTCH1 NOTCH4

2.96e-047712SM00004
DomainKazal_2

SPOCK3 SMOC1 SMOC2

3.44e-0436713PF07648
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

MUC17 MUC5B MUC4 MUC5AC NOTCH1 NOTCH4

2.70e-0768566M27303
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC17 MUC5B MUC4 MUC5AC

3.92e-0716564M27410
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC17 MUC5B MUC4 MUC5AC

5.11e-0717564M27412
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300 NOTCH1 NOTCH4

1.03e-0620564M27881
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC17 MUC5B MUC4 MUC5AC

1.27e-0621564MM15706
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC17 MUC5B MUC4 MUC5AC

1.87e-0623564M556
PathwayREACTOME_DECTIN_2_FAMILY

MUC17 MUC5B MUC4 MUC5AC

3.13e-0626564M27483
PathwayREACTOME_REGULATION_OF_NFE2L2_GENE_EXPRESSION

CREBBP EP300 NOTCH1

3.28e-068563M48024
PathwayREACTOME_NFE2L2_REGULATING_TUMORIGENIC_GENES

CREBBP EP300 NOTCH1

9.58e-0611563M48021
PathwayREACTOME_C_TYPE_LECTIN_RECEPTORS_CLRS

MUC17 MUC5B MUC4 MUC5AC CREBBP EP300

1.86e-05140566M27484
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

CREBBP EP300 NOTCH1

2.10e-0514563M27808
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

MUC17 MUC5B MUC4 MUC5AC NOTCH1 NOTCH4

2.10e-05143566M27275
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_LATE_STAGE_BRANCHING_MORPHOGENESIS_PANCREATIC_BUD_PRECURSOR_CELLS

CREBBP EP300 NOTCH1

3.21e-0516563M27121
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

CREBBP EP300 NOTCH1 NOTCH4

3.51e-0547564M7946
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

MUC17 MUC5B MUC4 MUC5AC

9.23e-0560564MM15636
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

MUC17 MUC5B MUC4 MUC5AC

1.05e-0462564M546
PathwayWP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA

INSRR CREBBP EP300 NOTCH1

1.26e-0465564M39682
PathwayREACTOME_NOTCH3_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300 NOTCH1

1.28e-0425563M27880
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

1.54e-045562MM1575
PathwayREACTOME_NFE2L2_REGULATING_INFLAMMATION_ASSOCIATED_GENES

CREBBP EP300

1.54e-045562M48020
PathwayREACTOME_NFE2L2_REGULATING_ER_STRESS_ASSOCIATED_GENES

CREBBP EP300

1.54e-045562M48023
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH1 NOTCH4

1.54e-045562M27411
PathwayREACTOME_LRR_FLII_INTERACTING_PROTEIN_1_LRRFIP1_ACTIVATES_TYPE_I_IFN_PRODUCTION

CREBBP EP300

1.54e-045562M27228
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH4

1.54e-045562MM14733
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

CREBBP NOTCH1 NOTCH4

1.81e-0428563M6177
PathwayBIOCARTA_PELP1_PATHWAY

CREBBP EP300

2.30e-046562M22062
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH1 NOTCH4

2.30e-046562M27068
PathwayREACTOME_SIGNALING_BY_NOTCH4

CREBBP EP300 NOTCH1 NOTCH4

3.10e-0482564M594
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

3.21e-047562MM1573
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

NOTCH1 NOTCH4

3.21e-047562MM14734
PathwayBIOCARTA_PPARG_PATHWAY

CREBBP EP300

4.27e-048562M22058
PathwayREACTOME_NFE2L2_REGULATING_MDR_ASSOCIATED_ENZYMES

CREBBP EP300

4.27e-048562M48022
PathwayREACTOME_NFE2L2_REGULATES_PENTOSE_PHOSPHATE_PATHWAY_GENES

CREBBP EP300

4.27e-048562M46443
PathwayREACTOME_DISEASES_OF_METABOLISM

MUC17 MUC5B MUC4 MUC5AC NOTCH1 NOTCH4

4.53e-04250566M27554
PathwayREACTOME_SIGNALING_BY_NOTCH

EP300 NOTCH1 NOTCH4

4.90e-0439563MM14604
PathwayKEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY

CREBBP EP300

5.48e-049562M47451
PathwayREACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT

CREBBP EP300 NOTCH1

6.11e-0442563M17541
PathwayREACTOME_RUNX3_REGULATES_NOTCH_SIGNALING

EP300 NOTCH1

6.83e-0410562MM15535
PathwayREACTOME_REGULATION_OF_FOXO_TRANSCRIPTIONAL_ACTIVITY_BY_ACETYLATION

CREBBP EP300

6.83e-0410562M27945
PathwayPID_HNF3A_PATHWAY

PRDM15 CREBBP EP300

7.01e-0444563M285
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

LRP10 ENPP1 LRP1 LRP2 LRP4 LOXL4 ENDOU

7.39e-04381567M48063
PathwayWP_NOTCH_SIGNALING_WP268

CREBBP NOTCH1 NOTCH4

7.49e-0445563M39571
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

LRP10 LRP1 LRP2

7.49e-0445563MM15344
PathwayWP_NOTCH_SIGNALING_PATHWAY

CREBBP NOTCH1 NOTCH4

7.99e-0446563MM15971
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

8.33e-0411562MM1521
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH1 NOTCH4

8.33e-0411562M47865
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_BY_HYPOXIA_INDUCIBLE_FACTOR

CREBBP EP300

8.33e-0411562M26924
PathwayPID_HES_HEY_PATHWAY

CREBBP EP300 NOTCH1

9.05e-0448563M288
PathwayREACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

CREBBP EP300 NOTCH1

9.05e-0448563M611
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

LRP10 LRP1 LRP2

9.05e-0448563M27642
PathwayREACTOME_O_LINKED_GLYCOSYLATION

MUC17 MUC5B MUC4 MUC5AC

9.12e-04109564MM15164
PathwayREACTOME_SENSORY_PERCEPTION

OR2B11 LRP10 LRP1 LRP2 GNAT3

9.24e-04190565MM15687
PathwayREACTOME_SIGNALING_BY_NOTCH3

CREBBP EP300 NOTCH1

9.61e-0449563M618
PathwayREACTOME_O_LINKED_GLYCOSYLATION

MUC17 MUC5B MUC4 MUC5AC

9.76e-04111564M27416
PathwayBIOCARTA_CARM1_PATHWAY

CREBBP EP300

9.97e-0412562M7968
PathwayREACTOME_ACTIVATION_OF_THE_TFAP2_AP_2_FAMILY_OF_TRANSCRIPTION_FACTORS

CREBBP EP300

9.97e-0412562M27765
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH1 NOTCH4

9.97e-0412562M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH1 NOTCH4

9.97e-0412562M47533
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH4

1.18e-0313562M47423
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH1 NOTCH4

1.18e-0313562M47534
PathwayREACTOME_PRE_NOTCH_EXPRESSION_AND_PROCESSING

CREBBP EP300 NOTCH1 NOTCH4

1.26e-03119564M607
PathwayREACTOME_SIGNALING_BY_NOTCH1_PEST_DOMAIN_MUTANTS_IN_CANCER

CREBBP EP300 NOTCH1

1.57e-0358563M29616
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

1.57e-0315562MM1339
PathwayBIOCARTA_RELA_PATHWAY

CREBBP EP300

1.57e-0315562M10183
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

1.57e-0315562MM1439
PathwayREACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY

CREBBP EP300

1.57e-0315562M953
PathwayPID_NOTCH_PATHWAY

EP300 NOTCH1 NOTCH4

1.65e-0359563M17
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

NOTCH1 NOTCH4

1.79e-0316562M47424
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

1.79e-0316562M1296
PathwayBIOCARTA_IL7_PATHWAY

CREBBP EP300

1.79e-0316562MM1420
PathwayBIOCARTA_PITX2_PATHWAY

CREBBP EP300

1.79e-0316562M8516
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_DEATH_GENES

CREBBP EP300

1.79e-0316562M27940
PathwayWP_NOTCH_SIGNALING_WP61

EP300 NOTCH1 NOTCH4

1.82e-0361563M39540
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

2.03e-0317562MM1509
PathwayREACTOME_ZYGOTIC_GENOME_ACTIVATION_ZGA

CREBBP EP300

2.03e-0317562M48025
PathwayWP_NOTCH1_REGULATION_OF_ENDOTHELIAL_CELL_CALCIFICATION

PLAT NOTCH1

2.03e-0317562M39389
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH1 NOTCH4

2.28e-0318562M614
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

CREBBP EP300

2.28e-0318562M26942
PathwayREACTOME_SIGNALING_BY_NOTCH1

EP300 NOTCH1

2.28e-0318562MM14775
PathwayBIOCARTA_TGFB_PATHWAY

CREBBP EP300

2.54e-0319562M18933
PathwayREACTOME_NFE2L2_REGULATING_ANTI_OXIDANT_DETOXIFICATION_ENZYMES

CREBBP EP300

2.54e-0319562M46442
PathwayREACTOME_FORMATION_OF_PARAXIAL_MESODERM

CREBBP EP300 NOTCH1

2.58e-0369563M46439
PathwayKEGG_WNT_SIGNALING_PATHWAY

WNT9B PRICKLE2 CREBBP EP300

3.02e-03151564M19428
PathwayWP_HEMATOPOIETIC_STEM_CELL_GENE_REGULATION_BY_GABP_ALPHABETA_COMPLEX

CREBBP EP300

3.10e-0321562M39593
PathwayREACTOME_CD209_DC_SIGN_SIGNALING

CREBBP EP300

3.10e-0321562M27485
PathwayREACTOME_SIGNALING_BY_NOTCH1

CREBBP EP300 NOTCH1

3.15e-0374563M616
PathwayBIOCARTA_VDR_PATHWAY

CREBBP EP300

3.40e-0322562MM1370
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP EP300

3.40e-0322562MM1443
PathwayBIOCARTA_NTHI_PATHWAY

CREBBP EP300

3.72e-0323562M2821
PathwayREACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY

NOTCH1 NOTCH4

3.72e-0323562MM14954
PathwayWP_15Q133_COPY_NUMBER_VARIATION_SYNDROME

GRM6 CREBBP

3.72e-0323562M39883
PathwayBIOCARTA_VDR_PATHWAY

CREBBP EP300

4.04e-0324562M13404
PathwayKEGG_DORSO_VENTRAL_AXIS_FORMATION

NOTCH1 NOTCH4

4.04e-0324562M11190
PathwayWP_DELTANOTCH_SIGNALING_PATHWAY

EP300 NOTCH1 NOTCH4

4.21e-0382563MM15922
PathwayBIOCARTA_CARM_ER_PATHWAY

CREBBP EP300

4.74e-0326562M2499
PathwayPID_HDAC_CLASSIII_PATHWAY

CREBBP EP300

4.74e-0326562M32
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

NOTCH1 NOTCH4

5.10e-0327562M39545
PathwayKEGG_PROSTATE_CANCER

INSRR CREBBP EP300

5.30e-0389563M13191
PathwayWP_GASTRIC_CANCER_NETWORK_1

SMOC2 NOTCH1

5.48e-0328562M39347
PathwayREACTOME_ATTENUATION_PHASE

CREBBP EP300

5.48e-0328562M27254
Pubmed

Chromosomal organization of candidate genes involved in cholesterol gallstone formation: a murine gallstone map.

MUC17 LRP1 LRP2 MUC5B MUC5AC

4.41e-084771511208732
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC17 MUC5B MUC4 MUC5AC

4.77e-081871418834073
Pubmed

Polymorphism of human mucin genes in chest disease: possible significance of MUC2.

MUC5B MUC4 MUC5AC

8.13e-08571311062147
Pubmed

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.

LRP1 LRP2 LRP4

8.13e-08571319047013
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

LRP1 LRP2 ZNF318 MUC5AC CRB1

3.60e-077171533541421
Pubmed

Transcriptome-based systematic identification of extracellular matrix proteins.

VWC2 SPOCK3 NID1 SMOC1 SMOC2

6.16e-077971518757743
Pubmed

LDL receptor-related protein as a component of the midkine receptor.

LRP1 LRP2 NID1

6.79e-07971310772929
Pubmed

TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.

LRP10 ADAM15 ENPP1 LRP1 PLAT MUC5B

1.11e-0616471632409323
Pubmed

LRP2 mediates folate uptake in the developing neural tube.

LRP1 LRP2 LRP4

1.33e-061171324639464
Pubmed

Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.

MUC5B MUC5AC NOTCH1 NOTCH4

1.52e-064171422675208
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

INSRR LRP1 LRP2 LOXL4 NOTCH1

2.09e-0610171523382219
Pubmed

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.

MUC5B MUC5AC NOTCH1

2.92e-061471322797898
Pubmed

Loss of p300 accelerates MDS-associated leukemogenesis.

CREBBP EP300

4.11e-06271227881875
Pubmed

Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).

MUC5B MUC5AC

4.11e-0627127513696
Pubmed

Molecular characterization of the histone acetyltransferase CREBBP/EP300 genes in myeloid neoplasia.

CREBBP EP300

4.11e-06271234845315
Pubmed

The association between MUC5AC and MUC5B genes expression and remodeling progression in severe neutrophilic asthma: A direct relationship.

MUC5B MUC5AC

4.11e-06271237146737
Pubmed

p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.

CREBBP EP300

4.11e-06271219729597
Pubmed

Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation.

NOTCH1 NOTCH4

4.11e-06271224305720
Pubmed

MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.

MUC5B MUC5AC

4.11e-06271214988081
Pubmed

Notch signaling in cancer.

NOTCH1 NOTCH4

4.11e-06271212496471
Pubmed

Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions.

MUC5B MUC5AC

4.11e-06271215563276
Pubmed

The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis.

MUC5B MUC5AC

4.11e-06271217621824
Pubmed

MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer.

MUC4 MUC5AC

4.11e-06271218475301
Pubmed

Muc5b is required for airway defence.

MUC5B MUC5AC

4.11e-06271224317696
Pubmed

The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors.

LRP1 PLAT

4.11e-06271218321860
Pubmed

Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells.

MUC5B MUC5AC

4.11e-06271222391959
Pubmed

Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.

MUC5B MUC5AC

4.11e-06271235776514
Pubmed

CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer.

CREBBP EP300

4.11e-06271239287984
Pubmed

The ocular surface phenotype of Muc5ac and Muc5b null mice.

MUC5B MUC5AC

4.11e-06271224327612
Pubmed

Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy.

NOTCH1 NOTCH4

4.11e-06271223389453
Pubmed

Notch signaling: from the outside in.

NOTCH1 NOTCH4

4.11e-06271211112321
Pubmed

Exon deletions of the EP300 and CREBBP genes in two children with Rubinstein-Taybi syndrome detected by aCGH.

CREBBP EP300

4.11e-06271220717166
Pubmed

Thymosin beta4 induces angiogenesis through Notch signaling in endothelial cells.

NOTCH1 NOTCH4

4.11e-06271223749167
Pubmed

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.

CREBBP EP300

4.11e-06271225893291
Pubmed

Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300.

CREBBP EP300

4.11e-06271211559821
Pubmed

Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family.

LRP10 LRP4

4.11e-06271220005200
Pubmed

Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation.

LRP1 PLAT

4.11e-06271210632583
Pubmed

Gel-forming mucins form distinct morphologic structures in airways.

MUC5B MUC5AC

4.11e-06271228607090
Pubmed

CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.

CREBBP EP300

4.11e-06271232576962
Pubmed

Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.

CREBBP EP300

4.11e-06271219822209
Pubmed

A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.

CREBBP EP300

4.11e-06271224522976
Pubmed

CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement.

CREBBP EP300

4.11e-06271221847097
Pubmed

Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss.

SMOC1 SMOC2

4.11e-06271232908163
Pubmed

Notch-1 and notch-4 receptors as prognostic markers in breast cancer.

NOTCH1 NOTCH4

4.11e-06271220444726
Pubmed

Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.

MUC5B MUC5AC

4.11e-06271231030254
Pubmed

The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.

MUC5B MUC5AC

4.11e-06271223527003
Pubmed

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

CREBBP EP300

4.11e-06271234813504
Pubmed

Characterization of SMOC-2, a modular extracellular calcium-binding protein.

SMOC1 SMOC2

4.11e-06271212741954
Pubmed

Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion.

MUC5B MUC5AC

4.11e-06271216540890
Pubmed

Rubinstein-Taybi Syndrome

CREBBP EP300

4.11e-06271220301699
Pubmed

Potential biomarker of metformin action.

CREBBP EP300

4.11e-06271224639469
Pubmed

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels.

CREBBP EP300

4.11e-06271237816914
Pubmed

Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.

MUC5B MUC5AC

4.11e-06271227845589
Pubmed

Binding of p300/CBP co-activators by polyoma large T antigen.

CREBBP EP300

4.11e-06271211438528
Pubmed

Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators.

CREBBP EP300

4.11e-06271210918613
Pubmed

Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.

CREBBP EP300

4.11e-06271235502657
Pubmed

p300 and cAMP response element-binding protein-binding protein in skeletal muscle homeostasis, contractile function, and survival.

CREBBP EP300

4.11e-06271231898871
Pubmed

Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.

MUC5B MUC5AC

4.11e-06271227435107
Pubmed

NOTCH1 and CREBBP co-mutations negatively affect the benefit of adjuvant therapy in completely resected EGFR-mutated NSCLC: translational research of phase III IMPACT study.

CREBBP NOTCH1

4.11e-06271237864465
Pubmed

Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity.

CREBBP EP300

4.11e-06271230888860
Pubmed

Mucins MUC5B and MUC5AC in Distal Airways and Honeycomb Spaces: Comparison among Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia, Fibrotic Nonspecific Interstitial Pneumonitis, and Control Lungs.

MUC5B MUC5AC

4.11e-06271226871672
Pubmed

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.

CREBBP EP300

4.11e-06271227881443
Pubmed

Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts.

CREBBP EP300

4.11e-06271219272189
Pubmed

Differential contribution of p300 and CBP to regulatory element acetylation in mESCs.

CREBBP EP300

4.11e-06271232690000
Pubmed

Aggregated low-density lipoprotein induces LRP1 stabilization through E3 ubiquitin ligase CHFR downregulation in human vascular smooth muscle cells.

CHFR LRP1

4.11e-06271223241409
Pubmed

CBP/p300 antagonises EGFR-Ras-Erk signalling and suppresses increased Ras-Erk signalling-induced tumour formation in mice.

CREBBP EP300

4.11e-06271230953353
Pubmed

Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control.

CREBBP EP300

4.11e-06271221803292
Pubmed

HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter.

CREBBP EP300

4.11e-0627129811832
Pubmed

Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.

CREBBP EP300

4.11e-06271224089570
Pubmed

Expression of mucins in mucoid otitis media.

MUC5B MUC4

4.11e-06271214690056
Pubmed

In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model.

MUC5B MUC5AC

4.11e-06271211587997
Pubmed

Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma.

NOTCH1 NOTCH4

4.11e-06271226530164
Pubmed

Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.

CREBBP EP300

4.11e-06271215706485
Pubmed

AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer.

CREBBP EP300

4.11e-06271239266679
Pubmed

Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice.

MUC4 MUC5AC

4.11e-06271219158956
Pubmed

A boy with classical Rubinstein-Taybi syndrome but no detectable mutation in the CREBBP and EP300 genes.

CREBBP EP300

4.11e-06271222303793
Pubmed

Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.

CREBBP EP300

4.11e-06271234732714
Pubmed

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition.

CREBBP EP300

4.11e-06271234019788
Pubmed

Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma.

MUC5B MUC5AC

4.11e-06271234656442
Pubmed

Introduction to Notch signaling.

NOTCH1 NOTCH4

4.11e-06271225053477
Pubmed

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

LRP1 PLAT

4.11e-0627121502153
Pubmed

Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.

MUC5B MUC5AC

4.11e-06271234058148
Pubmed

Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation.

CREBBP EP300

4.11e-06271215860545
Pubmed

Further delineation of an entity caused by CREBBP and EP300 mutations but not resembling Rubinstein-Taybi syndrome.

CREBBP EP300

4.11e-06271229460469
Pubmed

Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.

LRP1 LRP2

4.11e-06271234445520
Pubmed

Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.

CREBBP EP300

4.11e-06271224551300
Pubmed

Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma.

CREBBP EP300

4.11e-06271233911074
Pubmed

The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.

CREBBP EP300

4.11e-0627129018065
Pubmed

Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure.

CREBBP EP300

4.11e-06271224648406
Pubmed

C-Mannosylation of MUC5AC and MUC5B Cys subdomains.

MUC5B MUC5AC

4.11e-06271214718370
Pubmed

CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity.

CREBBP EP300

4.11e-06271230135524
Pubmed

Distribution of co-activators CBP and p300 during mouse oocyte and embryo development.

CREBBP EP300

4.11e-06271216596650
Pubmed

The p300 and CBP Transcriptional Coactivators Are Required for β-Cell and α-Cell Proliferation.

CREBBP EP300

4.11e-06271229217654
Pubmed

Mucin production during prenatal and postnatal murine lung development.

MUC5B MUC5AC

4.11e-06271221653907
Pubmed

Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma.

NOTCH1 NOTCH4

4.11e-06271225031748
Pubmed

Differences in the interactions of oncogenic adenovirus 12 early region 1A and nononcogenic adenovirus 2 early region 1A with the cellular coactivators p300 and CBP.

CREBBP EP300

4.11e-06271210049825
Pubmed

MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.

MUC5B MUC5AC

4.11e-06271236427316
Pubmed

CBP/p300 acetyltransferase activity in hematologic malignancies.

CREBBP EP300

4.11e-06271227380996
Pubmed

CREBBP and p300 lysine acetyl transferases in the DNA damage response.

CREBBP EP300

4.11e-06271229170789
Pubmed

Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis.

CREBBP EP300

4.11e-06271221555743
InteractionMAML2 interactions

CREBBP EP300 NOTCH1 NOTCH4

2.90e-0717694int:MAML2
InteractionTYW3 interactions

SCFD2 VWC2 BUB1B LRP4 ALPK2

1.03e-0653695int:TYW3
InteractionCCN2 interactions

LRP1 LRP2 CREBBP EP300

1.05e-0540694int:CCN2
GeneFamilyLow density lipoprotein receptors

LRP10 LRP1 LRP2 LRP4

3.07e-0813484634
GeneFamilyCD molecules|Mucins

MUC17 MUC5B MUC4 MUC5AC

2.53e-0721484648
GeneFamilySPARC family

SPOCK3 SMOC1 SMOC2

9.74e-0784831278
GeneFamilyLIM domain containing

LMO2 PRICKLE2 FHL5 PDLIM5

1.79e-05594841218
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

9.15e-0417482486
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

CREBBP EP300

1.03e-031848291
GeneFamilyRing finger proteins

RNF5 RNF19B CHFR RNF8

6.03e-0327548458
CoexpressionNABA_MATRISOME

VWC2 CRIM1 MUC17 SPOCK3 ADAM15 WNT9B KCP LOXL4 NID1 PLAT MUC5B SMOC1 SMOC2 MUC4 MUC5AC

6.53e-0810087115MM17056
CoexpressionNABA_MATRISOME

VWC2 CRIM1 MUC17 SPOCK3 ADAM15 WNT9B KCP LOXL4 NID1 PLAT MUC5B SMOC1 SMOC2 MUC4 MUC5AC

8.23e-0810267115M5889
ToppCelldroplet-Liver-HEPATOCYTES-1m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DIP2A LMO2 UMODL1 MYO9A WFDC9 TNFRSF11A

2.18e-07160716a494001b1f6dec33624f98fa3c24bad6988d0425
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP2 LOXL4 NID1 PLAT SMOC2

5.44e-071877164e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP2 LOXL4 NID1 PLAT SMOC2

5.44e-07187716d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP2 LOXL4 NID1 PLAT SMOC2

5.44e-07187716827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 ENPP1 LRP1 NID1 SMOC2 PDLIM5

6.35e-07192716bc84b9ce01b4d826a682842ab8a395dac9b91183
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 KCP NID1 TWSG1 SMOC2

6.35e-07192716671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 KCP NID1 TWSG1 SMOC2

6.35e-07192716840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 ENPP1 LRP1 NID1 SMOC2 PDLIM5

6.35e-071927160ab1176cfbb0de8dd1f22c6e2c41265cf6c10ee1
ToppCellLA|World / Chamber and Cluster_Paper

ITGBL1 NWD2 PRICKLE2 LRP1 LRP2 SMOC2

6.55e-07193716d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 ENPP1 LRP1 NID1 SMOC2 PDLIM5

7.38e-07197716ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 ENPP1 LRP1 NID1 SMOC2 PDLIM5

7.38e-0719771637f6b6f2809b952382eaebb642b0aad6371f4251
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

CRIM1 KCP NID1 PLAT FHL5 PDLIM5

8.06e-072007164e1e19214aeebbdca004de7faaf4cc9d18498591
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-OPRM1|Neuronal / cells hierarchy compared to all cells using T-Statistic

FAM170B VWC2 NID1 PLAT SMOC1 SMOC2

8.06e-07200716559cf4001a3f985c8357f0102b34fab2e34d2a04
ToppCellNeuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-OPRM1-L1-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

FAM170B VWC2 NID1 PLAT SMOC1 SMOC2

8.06e-07200716cc0d639d38eb99414ba8b54d3000701962394465
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 ENPP1 PRICKLE2 NID1 SMOC1

9.40e-061777159ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 ENPP1 PRICKLE2 NID1 SMOC1

9.40e-06177715016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCellnucseq-Epithelial-Epithelial_Glandular|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC17 PLAT MUC5B MUC4 MUC5AC

9.92e-06179715859cd8ee414ad6207c046ada2e655e49322dd01c
ToppCellPCW_10-12-Endothelial-Endothelial_mature-lymphatic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

LMO2 SPOCK3 GNAT3 TNFRSF11A SMOC1

9.92e-06179715ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCellPCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

LMO2 SPOCK3 GNAT3 TNFRSF11A SMOC1

9.92e-0617971535fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCellnucseq-Epithelial-Epithelial_Glandular-Goblet|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC17 PLAT MUC5B MUC4 MUC5AC

1.02e-051807153dc80bc636bf0e6ffc9762853132a9fe59fd1f66
ToppCellnucseq-Epithelial-Epithelial_Glandular-Goblet-Goblet|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MUC17 PLAT MUC5B MUC4 MUC5AC

1.02e-05180715668a2d8e1d5a390309d5eb62c836f5903144bea9
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VWC2 NID1 PLAT SMOC1 PDLIM5

1.08e-05182715724c33ad2fb525cbcfa5efa3362675eb42a5636d
ToppCellControl-Epithelial_cells-Airway_mucous|Control / group, cell type (main and fine annotations)

MUC17 PLAT MUC5B MUC4 MUC5AC

1.10e-0518371515d24a4fb1ffe6cbafbd54fcd7dde9ddcfbe03b2
ToppCellPCW_10-12-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ENPP1 TNFRSF11A KLRC1 APBB1IP TG

1.13e-051847153e9d75af578297950e469f23fb2d28393a2feef8
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 LRP1 NID1 SMOC1 SMOC2

1.13e-05184715e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCellControl-Epithelial_cells-Airway_goblet|Control / group, cell type (main and fine annotations)

MUC17 PLAT MUC5B MUC4 MUC5AC

1.13e-05184715d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 LRP4 NID1 SMOC2

1.16e-05185715eaa54b76743628c89b4310be57b87fa92b75fd37
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 LRP4 NID1 SMOC2

1.16e-05185715f7f4c921d248c637351e2e882589b99ba7f04b66
ToppCellPCW_13-14-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LMO2 SPOCK3 GNAT3 TNFRSF11A SMOC1

1.16e-051857153be9e05b929ac4d956b1d53284072f668a6c1959
ToppCellfacs-Thymus-Epithelium-24m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 LRP4 NID1 SMOC2

1.16e-05185715ff38a15af3dec36d9993f06623591872b5d1da9a
ToppCellPCW_13-14-Endothelial-Endothelial_mature-lymphatic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LMO2 SPOCK3 GNAT3 TNFRSF11A SMOC1

1.16e-05185715c3dd64a726cb8a1fe048683c266b7532a714a52e
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-lymphatic|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LMO2 SPOCK3 GNAT3 TNFRSF11A SMOC1

1.19e-051867155d94e6dd2c92e0c46badeb1e6eb54b69af855a66
ToppCellPCW_07-8.5-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LMO2 SPOCK3 GNAT3 TNFRSF11A SMOC1

1.19e-051867151da52e13096dfe4eb08bd0e7461cb3809b3b3deb
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

ITGBL1 CRIM1 SMOC2 FHL5 PDLIM5

1.23e-05187715464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|343B / Donor, Lineage, Cell class and subclass (all cells)

ENPP1 PRICKLE2 PLAT NOTCH4 SEC14L1

1.26e-05188715fe7143c36e4a883745862d3c3147cf751b440e46
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|343B / Donor, Lineage, Cell class and subclass (all cells)

ENPP1 PRICKLE2 PLAT NOTCH4 SEC14L1

1.26e-05188715cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.29e-05189715e60a3d6aa84788c29f23439f1c747431ea581bc3
ToppCellCOVID-19-lung-Lymphatic_EC|lung / Disease (COVID-19 only), tissue and cell type

LMO2 GNAT3 NID1 TNFRSF11A SMOC1

1.29e-05189715c8db9aaf54ea3cc96c4a2f777c3389e0f31f67f3
ToppCellIPF-Epithelial-Basal|Epithelial / Disease state, Lineage and Cell class

SPOCK3 LRP4 LOXL4 NOTCH1 NOTCH4

1.32e-051907154f15842b424eefadbfe451875e517cf70e29607f
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel|Adult / Lineage, Cell type, age group and donor

LMO2 GNAT3 NID1 TNFRSF11A SMOC1

1.32e-0519071591bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCelldroplet-Limb_Muscle-nan-24m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 NID1 PLAT SMOC2

1.32e-05190715ad0f5605db6b694445ec9bd5dc8d2d834358c0f9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 ENPP1 LRP1 NID1 PDLIM5

1.36e-05191715a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWC2 ITGBL1 LRP1 SMOC1 SMOC2

1.36e-051917152b73fcd592d16cae8ded5e45c8fbf2d9adc8caad
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 LRP1 NID1 SMOC2 PDLIM5

1.36e-0519171539092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 NID1 PLAT SMOC2

1.36e-051917151b26056df078674f37a6c06f6256b30cfcec21a7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 ENPP1 LRP1 NID1 PDLIM5

1.36e-051917158f6d592edc32fdb901af30501d4360512334e8c2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 LRP1 NID1 SMOC2 PDLIM5

1.36e-05191715ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWC2 ITGBL1 LRP1 NID1 SMOC2

1.39e-05192715853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCelldroplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 NID1 PLAT SMOC2

1.39e-0519271511088878043a6ff95ba1970361256a82e434b80a
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 NID1 PLAT SMOC2

1.39e-05192715beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWC2 ITGBL1 LRP1 NID1 SMOC2

1.39e-05192715d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c5-CD16|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

LMO2 ENPP1 CHFR LRP1 KDM1B

1.39e-05192715af453a179f3fdd4ae870f1d98a485e8c9fd726ac
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid-Monocytic-Nonclassical_Monocyte|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

LMO2 ENPP1 CHFR LRP1 KDM1B

1.39e-05192715176b9c1dd2c91bca46e12fa5060bfe590dc18246
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.39e-051927153259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Myeloid-Monocytic|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

LMO2 ENPP1 CHFR LRP1 KDM1B

1.39e-0519271581f93b4c853f176c91b5ddef34238e37047a0e69
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWC2 ITGBL1 LRP1 NID1 SMOC2

1.39e-0519271549281626ecad0456fdbded2378b7028d7b589686
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWC2 ITGBL1 LRP1 SMOC1 SMOC2

1.43e-0519371592048d2e9e43513e6185e09553be3ee47d7e5207
ToppCellfacs-Lung-nan-3m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 NID1 TWSG1 SMOC2

1.43e-05193715d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWC2 ITGBL1 LRP1 SMOC1 SMOC2

1.43e-05193715ac088c8f27b5b1888610e461ff45870ca60da886
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.43e-051937156a623acd1adad9a78eddc32ffedb16352ad3fdfa
ToppCellControl-NK_CD56bright|Control / Disease condition and Cell class

ENPP1 TNFRSF11A KLRC1 NOTCH1 SEC14L1

1.43e-051937158b1e7a226a6057e1097c1525984127b54e823876
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 LRP1 NID1 SMOC2 PDLIM5

1.46e-0519471581713e0409e8be695ba5dfdc67a997b33435dd9e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PDLIM5 NOTCH4 SEC14L1

1.46e-05194715a429d22c8c9d0fd3bfa9f877a6364cecad68db30
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ENPP1 LRP2 LOXL4 ALPK2 APBB1IP

1.46e-0519471570185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CRIM1 LMO2 NID1 NOTCH4 SEC14L1

1.46e-05194715ea5e1bc8d9e27cabfe1fb833ca47ec0893593b12
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 LRP1 NID1 SMOC2 PDLIM5

1.46e-05194715e03ba6caed59fa64d4d9b042593469d4a6a3dc10
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.46e-05194715ad6c04ad0621689e3bf4c94ccd6e60653bbd02c7
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CRIM1 LMO2 NID1 NOTCH4 SEC14L1

1.46e-05194715cceb7c88492bb6cd531e1c2651638da1ddf30931
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 LRP1 NID1 SMOC2 PDLIM5

1.46e-05194715627cffe2d448e74fc5df92e74e5b922a73304137
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 LRP1 NID1 SMOC2 PDLIM5

1.50e-0519571549c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCellLA-02._Fibroblast_II|World / Chamber and Cluster_Paper

ITGBL1 PRICKLE2 LRP1 NID1 SMOC2

1.50e-05195715a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ITGBL1 LRP1 NID1 SMOC2 PDLIM5

1.50e-05195715dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCellfacs-Heart-LA-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP1 LRP1 NID1 TWSG1 SMOC2

1.50e-0519571579a6e8e6de040ff07539e8901fc407363a50e355
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LMO2 ADAM15 NOTCH1 NOTCH4 SEC14L1

1.54e-05196715ae46d4b00be92e64e46252dcc156161b171eded4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.54e-051967158ad8efb631164b46f0c082572270188e5ead20bf
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 PLAT NOTCH1 NOTCH4 SEC14L1

1.54e-0519671565d882c6e7f6d5778b8a5fd4fdaf012e1b9f6100
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.54e-051967158f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.54e-0519671548b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.54e-05196715b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.54e-051967159606ea7e42f707e69ea891b3521037613b9675f5
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.54e-05196715473980c827443464d08a0be28c53e3536369b12a
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 NID1 TWSG1 SMOC2

1.54e-05196715b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.54e-05196715145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGBL1 LRP1 NID1 TWSG1 SMOC2

1.54e-05196715787c6cd92035e0b1108c2c086c42a229016e476b
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.54e-05196715e224338490691d92c1f70b57112fabdcc92b06a9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.54e-05196715d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.58e-05197715c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.58e-05197715cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCellmild_COVID-19-Non-classical_Monocyte|World / disease group, cell group and cell class (v2)

LMO2 KDM1B MFSD12 PDLIM5 NOTCH4

1.58e-05197715368644260f70895052a1d71171a9d882315354dd
ToppCell(4)_Endothelial_cells-(41)_EC-arteriolar|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

LMO2 ADAM15 LRP4 PLAT NOTCH4

1.58e-05197715482e3f8926880afed88ed37553ed2b5ed58b8c99
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.58e-051977152844dbcd0a673ed81c99920aa45858651a00736d
ToppCellfacs-Heart-LA-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ENPP1 LRP1 NID1 TWSG1 SMOC2

1.58e-051977152a91738cb6d7588869dd00deeea0cbbc2d6aa34d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.61e-0519871507701c73137947ed4a27e225975329235bbb8734
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

VWC2 LRP1 LOXL4 NID1 PLAT

1.61e-0519871509be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Myeloid-Monocytic-Classical_Monocyte-Mono_c2-CD14-HLA-DPB1|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LMO2 ADAM15 RNF19B LRP1 NID1

1.61e-05198715c26c909e95225440abdf558b1b858ffc06177000
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.61e-05198715fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LMO2 ADAM15 NOTCH1 NOTCH4 SEC14L1

1.65e-05199715b15304d3d3f6c254969b54a61bee3d9f368840b2
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.65e-051997158b62d43af8b2ebb4c1b2d068d50beaf35728dbe7
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.65e-05199715da5a88749d859d535daa030d0974485906cc0ba7
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LMO2 ADAM15 PLAT NOTCH4 SEC14L1

1.65e-05199715e6715288a586631676722f2323f0d833431161cf
DrugAC1L9FMG

LRP2 NID1 PLAT

1.01e-067713CID000444053
Drugmonatepil

LRP10 LRP1 LRP2 LRP4

1.94e-0629714CID000060810
DrugFlurandrenolide [1524-88-5]; Up 200; 9.2uM; MCF7; HT_HG-U133A

CLCN4 SPOCK3 LRP2 GRM6 MUC4 CREBBP TG

2.54e-061957176039_UP
DrugUrokinase

LRP2 NID1 PLAT

3.43e-0610713DB00013
Diseasediastolic blood pressure, systolic blood pressure

SCFD2 CRIM1 MYO9A ADAM15 LRP1 LOXL4 SMOC2 PDLIM5 WDR43 CRB1

3.47e-066706910EFO_0006335, EFO_0006336
DiseaseMenke-Hennekam syndrome

CREBBP EP300

5.39e-062692cv:C5681632
DiseaseRubinstein-Taybi syndrome (implicated_via_orthology)

CREBBP EP300

5.39e-062692DOID:1933 (implicated_via_orthology)
DiseaseRubinstein-Taybi syndrome

CREBBP EP300

5.39e-062692cv:C0035934
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

5.39e-062692C4551859
DiseaseRUBINSTEIN-TAYBI SYNDROME 1

CREBBP EP300

5.39e-062692180849
DiseaseRubinstein-Taybi syndrome due to CREBBP mutations

CREBBP EP300

5.39e-062692cv:C4551859
DiseaseRubinstein-Taybi syndrome (is_implicated_in)

CREBBP EP300

5.39e-062692DOID:1933 (is_implicated_in)
DiseaseRubinstein-Taybi Syndrome

CREBBP EP300

5.39e-062692C0035934
Diseasecholangiocarcinoma (is_marker_for)

MUC5B MUC4 MUC5AC NOTCH1

1.56e-0564694DOID:4947 (is_marker_for)
Diseasepulse pressure measurement, migraine with aura

LRP1 FHL5

3.22e-054692EFO_0005763, MONDO_0005475
DiseaseLeukemia, T-Cell

LMO2 NOTCH1

5.36e-055692C0023492
Diseasemucinous adenocarcinoma (is_marker_for)

MUC4 MUC5AC

5.36e-055692DOID:3030 (is_marker_for)
Diseasemigraine without aura

LRP1 FHL5

5.36e-055692MONDO_0100431
DiseaseSquamous cell carcinoma of esophagus

BUB1B CREBBP EP300 NOTCH1

7.43e-0595694C0279626
Diseaseuric acid measurement

CRIM1 MYO9A INSRR LRP2 ZNF318 GNAT2 MFSD12 CRB1

8.79e-05610698EFO_0004761
DiseaseAdenoid Cystic Carcinoma

INSRR CREBBP EP300 NOTCH1

9.07e-05100694C0010606
Diseasepancreatic cancer (is_marker_for)

ADAM15 BUB1B MUC4 MUC5AC

9.42e-05101694DOID:1793 (is_marker_for)
Diseasebiliary tract benign neoplasm (is_marker_for)

MUC4 MUC5AC

1.12e-047692DOID:0050625 (is_marker_for)
Diseasecommon bile duct neoplasm (is_marker_for)

MUC4 MUC5AC

1.50e-048692DOID:4608 (is_marker_for)
DiseaseMcCune Albright syndrome (implicated_via_orthology)

GNAT3 GNAT2

1.50e-048692DOID:1858 (implicated_via_orthology)
DiseaseAbdominal Migraine

LRP1 FHL5

1.92e-049692C0270858
Diseasehemangiopericytoma (is_marker_for)

NOTCH1 NOTCH4

1.92e-049692DOID:264 (is_marker_for)
DiseaseSick Headaches

LRP1 FHL5

1.92e-049692C0700438
DiseaseAcute Confusional Migraine

LRP1 FHL5

1.92e-049692C0521664
DiseaseStatus Migrainosus

LRP1 FHL5

1.92e-049692C0338489
Diseasepulse pressure measurement, migraine without aura, susceptibility to, 4

LRP1 FHL5

1.92e-049692EFO_0005763, MONDO_0011847
DiseaseCervical Migraine Syndrome

LRP1 FHL5

1.92e-049692C0007852
DiseaseHemicrania migraine

LRP1 FHL5

1.92e-049692C0018984
DiseaseSquamous cell carcinoma

CREBBP EP300 NOTCH1 NOTCH4

2.08e-04124694C0007137
Diseaseotitis media (is_marker_for)

MUC5B MUC4

2.40e-0410692DOID:10754 (is_marker_for)
Diseasepulmonary fibrosis

MUC5B MUC5AC

2.92e-0411692EFO_0009448
Diseaseidiopathic pulmonary fibrosis

MUC5B ZNF318 MUC5AC

3.27e-0457693EFO_0000768
DiseaseBladder Neoplasm

LOXL4 CREBBP EP300 NOTCH1

3.30e-04140694C0005695
DiseaseMalignant neoplasm of urinary bladder

LOXL4 CREBBP EP300 NOTCH1

3.39e-04141694C0005684
Diseaseautoimmune thyroiditis (is_implicated_in)

LRP2 TG

3.50e-0412692DOID:7188 (is_implicated_in)
Diseasepancreatic ductal carcinoma (is_marker_for)

MUC5B MUC4 MUC5AC

4.00e-0461693DOID:3587 (is_marker_for)
DiseaseMigraine Disorders

LRP1 FHL5

4.13e-0413692C0149931
DiseaseLiver Cirrhosis, Experimental

MINDY3 LMO2 NID1 PLAT SMOC1 SMOC2 ZDHHC13 APBB1IP

4.41e-04774698C0023893
Diseasepolychlorinated biphenyls measurement

UMODL1 SPOCK3 INSRR

4.82e-0465693EFO_0007042
Diseaseinterstitial lung disease

MUC5B MUC5AC NOTCH4

5.27e-0467693EFO_0004244
Diseasemigraine without aura, susceptibility to, 4

LRP1 FHL5

6.33e-0416692MONDO_0011847
Diseasecervical artery dissection

LRP1 FHL5

7.16e-0417692EFO_1000059
Diseaseotitis media (biomarker_via_orthology)

MUC4 MUC5AC

7.16e-0417692DOID:10754 (biomarker_via_orthology)
DiseaseCongenital Myasthenic Syndromes, Presynaptic

MYO9A LRP4

8.98e-0419692C0751884
Diseaseurate measurement

MYO9A ADAM15 LRP1 LRP2 LRP4 NID1 ZNF318 GNAT2

1.13e-03895698EFO_0004531
DiseaseCarcinoma, Pancreatic Ductal

NOTCH1 NOTCH4

1.44e-0324692C0887833
DiseaseDisorder of eye

GNAT2 SMOC1 GRM6 CRB1

1.55e-03212694C0015397
Diseasemedial orbital frontal cortex volume measurement

SPOCK3 SMOC2

1.56e-0325692EFO_0010315
Diseasediabetes mellitus (implicated_via_orthology)

INSRR LRP1

1.69e-0326692DOID:9351 (implicated_via_orthology)
Diseasemigraine disorder, pulse pressure measurement

LRP1 FHL5

1.69e-0326692EFO_0005763, MONDO_0005277
DiseaseVitiligo

TNFRSF11A SMOC2 TG

1.73e-03101693EFO_0004208
DiseaseColorectal cancer

BUB1B EP300

1.82e-0327692cv:C0346629
DiseaseCOLORECTAL CANCER

BUB1B EP300

1.82e-0327692114500
DiseaseNeoplasm of the large intestine

BUB1B EP300

1.82e-0327692cv:C0009404
DiseaseOral ulcer

KCP NOTCH4 CRB1

2.04e-03107693HP_0000155

Protein segments in the cluster

PeptideGeneStartEntry
LCANLEGSYWCVCHQ

UMODL1

281

Q5DID0
SKYRWFHNACCECIG

TWSG1

191

Q9GZX9
HFCSCYQYQDGCIVW

BUB1B

821

O60566
WHCTVCEDYDLCITC

EP300

1681

Q09472
CCTFQHWVYQKTSGC

ALPK2

2061

Q86TB3
VCDSNRHCYCEEGWA

ADAM15

666

Q13444
THCDCNVDWCLYEIY

APBB1IP

211

Q7Z5R6
TRWHCTVCEDYDLCI

CREBBP

1716

Q92793
CSSWLDKECVYFCHL

EDN2

51

P20800
GVCLSAFWYSHEQCC

CLCN4

101

P51793
HCWYEVTCVQCSLDG

NWD2

1096

Q9ULI1
AYAQACHDAGLCVSW

MUC5B

1131

Q9HC84
DFHYECECICSMWGG

MUC5B

5066

Q9HC84
CGHCPEEWITYSNSC

KLRC1

116

P26715
IDQYWHEDCLSCDLC

LMO2

46

P25791
CVSFSIYTAWGEHCE

MUC4

5346

Q99102
SACCDHSGSYCLVSW

MINDY3

96

Q9H8M7
VTVGCWDTYRHDIDC

LOXL4

666

Q96JB6
GGKCWQTHTQYRCEC

NOTCH1

1071

P46531
CWKYFSDGHCDSQCN

NOTCH1

1496

P46531
WIHCFEGVTCIIFCA

GNAT3

211

A8MTJ3
CVYETWVCDGQPDCA

LRP10

411

Q7Z4F1
CSGDCSNYIQLVWDH

GLIPR1L2

151

Q4G1C9
YTGDKCELDQCWEHC

LRP1

4226

Q07954
NEHIYNLWCSGRVCC

CCDC47

201

Q96A33
PTQCHGSTGYCWCVD

NID1

886

P14543
WHGNCCEDYEHLCTE

ENDOU

46

P21128
CCINYSSVCQGEKSW

ENPP1

176

P22413
CASGRCIPQHWYCDQ

LRP2

2871

P98164
CIPQHWYCDQETDCF

LRP2

2876

P98164
CIPSRWICDHYNDCG

LRP2

3771

P98164
AYAQACHEVGLCVSW

MUC5AC

1141

P98088
QCQCVCSGWGDPHYI

MUC5AC

4916

P98088
GYTWHDTCFVCSVCC

PDLIM5

556

Q96HC4
WLVTTNYGVRCVACC

FAM170B

196

A6NMN3
CTVQYAVFHWLGCTE

OR2B11

101

Q5JQS5
YDGQHWHATETCFCC

PRICKLE2

271

Q7Z3G6
AVCLQPFCHLYWGCT

CHFR

511

Q96EP1
NYWHETCFVCENCRQ

FHL5

121

Q5TD97
CCWHCEACDGYRFQV

GRM6

536

O15303
RWYHLSCGEHFCNEC

KDM1B

81

Q8NB78
RWDLDSCTHCYCLQG

CRIM1

831

Q9NZV1
CVACRHLYFQGACLW

INSRR

246

P14616
WCLCSVYSGHQSVLV

DIP2A

1206

Q14689
CEDSVDNYTCHCWPG

CRB1

316

P82279
HCCYTVHPENEDWTC

SEC14L1

111

Q92503
GPLCECHEWVCETYD

ITGBL1

86

O95965
CHEWVCETYDGSTCA

ITGBL1

91

O95965
SELCCRACVSFYHWA

MFSD12

431

Q6NUT3
QCLCVTTETHWYSGE

MUC17

4366

Q685J3
EGCQTEFCYHCKQIW

RNF19B

231

Q6ZMZ0
LNCAHSFCSYCINEW

RNF8

416

O76064
EAVVSVCGHLYCWPC

RNF5

36

Q99942
CYTCQCQDLTWLCIH

KCP

1106

Q6ZWJ8
FIWCEDCSQYHDSEC

PRDM15

311

P57071
WIHCFEGVTCIIFCA

GNAT2

211

P19087
TCCWTYCGNICLDNE

WFDC9

66

Q8NEX5
VYLDAACAESLHWGC

SCFD2

26

Q8WU76
YCQCLPGHTGQWCEV

NOTCH4

1031

Q99466
GYAWVTACSHIFCDQ

CCNB1IP1

21

Q9NPC3
QVQCHTYTGYCWCVT

SMOC1

126

Q9H4F8
QCHQSTGYCWCVLVD

SMOC1

261

Q9H4F8
ECTICHCTYEEGTWR

VWC2

296

Q2TAL6
ACCECGKTFYWREHL

ZNF444

251

Q8N0Y2
VEYCWCNSGRAQCHS

PLAT

66

P00750
NCCVARYDQHCLWTG

ZDHHC13

446

Q8IUH4
QVQCHSYTGYCWCVT

SMOC2

121

Q9H3U7
CHPSTGYCWCVLVDT

SMOC2

251

Q9H3U7
QCHGSVGQCWCVDRY

SPOCK3

351

Q9BQ16
WYCFECHLPGEVLIC

ZMYND11

101

Q15326
GWVDTHCLCYDFIIT

ULBP1

26

Q9BZM6
HLQWVYCCSISPDCS

WSB2

196

Q9NYS7
LVAFSCHCQVQWCCY

WNT9B

326

O14905
YEDVQCFSGECWCVN

TG

626

P01266
YDAGNHWCKDCNTIC

ZNF318

1061

Q5VUA4
RCACTAGYHWSQDCE

TNFRSF11A

111

Q9Y6Q6
CIQWHQDSGCLYSCS

WDR43

131

Q15061
YCIRSLWHCDGDNDC

LRP4

121

O75096
GISWHNIDYIDNTCC

MYO9A

581

B2RTY4